cryptocaryone and rugulactone

cryptocaryone has been researched along with rugulactone* in 1 studies

Other Studies

1 other study(ies) available for cryptocaryone and rugulactone

Article	Year
Inhibitors of the NF-kappaB activation pathway from Cryptocarya rugulosa. Journal of natural products, 2009, Mar-27, Volume: 72, Issue:3 The nuclear factor-kappaB (NF-kappaB) signaling pathway is constitutively active in many types of cancers and is a potential therapeutic target. Using a cell-based assay for stability of inhibitor of kappa B (IkappaB), a critical regulator of NF-kappaB activity, we found that an organic solvent extract of the plant Cryptocarya rugulosa inhibited constitutive NF-kappaB activity in human lymphoma cell lines. The active components were identified as rugulactone, a new alpha-pyrone (1), and the known cryptocaryone (2). Rugulactone was the more active compound, exhibiting up to 5-fold induction of IkappaB at 25 microg/mL; maximal activity was observed with 10 h exposure of test cells to 1 or 2. Topics: Antineoplastic Agents, Phytogenic; Cryptocarya; Drug Screening Assays, Antitumor; Humans; I-kappa B Kinase; Lactones; Malaysia; Molecular Structure; NF-kappa B; Plant Leaves; Plant Stems; Plants, Medicinal; Pyrones	2009

Article

Year

Inhibitors of the NF-kappaB activation pathway from Cryptocarya rugulosa.

Journal of natural products, 2009, Mar-27, Volume: 72, Issue:3

The nuclear factor-kappaB (NF-kappaB) signaling pathway is constitutively active in many types of cancers and is a potential therapeutic target. Using a cell-based assay for stability of inhibitor of kappa B (IkappaB), a critical regulator of NF-kappaB activity, we found that an organic solvent extract of the plant Cryptocarya rugulosa inhibited constitutive NF-kappaB activity in human lymphoma cell lines. The active components were identified as rugulactone, a new alpha-pyrone (1), and the known cryptocaryone (2). Rugulactone was the more active compound, exhibiting up to 5-fold induction of IkappaB at 25 microg/mL; maximal activity was observed with 10 h exposure of test cells to 1 or 2.

Topics: Antineoplastic Agents, Phytogenic; Cryptocarya; Drug Screening Assays, Antitumor; Humans; I-kappa B Kinase; Lactones; Malaysia; Molecular Structure; NF-kappa B; Plant Leaves; Plant Stems; Plants, Medicinal; Pyrones

2009