cromakalim has been researched along with histamine in 29 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (10.34) | 18.7374 |
| 1990's | 23 (79.31) | 18.2507 |
| 2000's | 3 (10.34) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Arch, JR; Challiss, RA; Patel, N | 1 |
| Cortijo, J; Morcillo, E; Paris, F; Pedrós, C; Perpiñá, M; Sarriá, B | 1 |
| Albus, U; Englert, HC; Fürst, U; Gehring, D; Rosenkranz, B; Schölkens, BA; Scholz, W; Wirth, K | 1 |
| Bang, L; Nielsen-Kudsk, JE | 1 |
| Arch, JR; Bowring, NE; Buckle, DR; Clarke, GD; Taylor, JF | 1 |
| Bang, L; Brønsgaard, AM; Nielsen-Kudsk, JE | 1 |
| Adeagbo, AS; Malik, KU | 1 |
| Allen, SL; Boyle, JP; Cortijo, J; Foster, RW; Morgan, GP; Small, RC | 1 |
| Cooper, SM; Wilson, C | 1 |
| Arch, JR; Buckle, DR; Bumstead, J; Clarke, GD; Taylor, JF; Taylor, SG | 1 |
| Ishimura, Y; Katoh, I; Masuda, Y; Oka, M; Yoshizumi, M | 1 |
| Ichinose, M; Igarashi, A; Inoue, H; Ishikawa, J; Maeyama, K; Miura, M; Nakajima, N; Takahashi, T; Watanabe, T; Yamauchi, H | 1 |
| Dave, KC; Goyal, RK; Mehta, AA | 1 |
| Advenier, C; Martin, CA | 1 |
| Kam, KL; Pfaffendorf, M; van Zwieten, PA | 1 |
| Cortijo, J; Morcillo, EJ; Ortiz, JL; Pedrós, C | 1 |
| Imagawa, J; Kamei, K; Koga, T; Nabata, H; Sugo, I; Yoshida, S | 1 |
| Arch, JR; Bowring, NE; Buckle, DR; Taylor, JF | 1 |
| Arch, JR; Bowring, NE; Buckle, DR; Foster, KA; Shaw, DJ; Taylor, JF; Taylor, SG | 1 |
| Barnes, PJ; Chung, KF; Fuller, RW; Kidney, JC; Lavender, EA; Worsdell, YM | 1 |
| Högestätt, ED; Ryman, T; Zygmunt, PM | 1 |
| Barnes, PJ; Chung, KF; Kidney, JC; Lei, Y; Lotvall, JO | 1 |
| Shikada, K; Tanaka, S | 1 |
| Goswami, S; Jain, S; Santani, D | 1 |
| Ando, T; Kume, H; Takagi, K; Urata, Y | 1 |
| Chang, M; Cheng, C; Lee, Y; Lin, C; Sheu, J; Yen, M | 1 |
| Bouskela, E; Simões, C; Svensjö, E | 1 |
| Advenier, C; Cortijo, J; Mata, M; Morcillo, EJ; Naline, E; Sarria, B | 1 |
| Brune, ME; Buckner, SA; Coghlan, M; Daza, A; Fey, TA; Gopalakrishnan, M; Milicic, I | 1 |
1 trial(s) available for cromakalim and histamine
| Article | Year |
|---|---|
Effect of an oral potassium channel activator, BRL 38227, on airway function and responsiveness in asthmatic patients: comparison with oral salbutamol.
Topics: Adult; Asthma; Benzopyrans; Bronchodilator Agents; Cromakalim; Double-Blind Method; Female; Forced Expiratory Volume; Histamine; Humans; Male; Methacholine Chloride; Middle Aged; Pyrroles; Time Factors; Vital Capacity | 1993 |
28 other study(ies) available for cromakalim and histamine
| Article | Year |
|---|---|
Comparative effects of BRL 38227, nitrendipine and isoprenaline on carbachol- and histamine-stimulated phosphoinositide metabolism in airway smooth muscle.
Topics: Animals; Benzopyrans; Carbachol; Cattle; Cromakalim; Histamine; In Vitro Techniques; Isoproterenol; Muscle, Smooth; Nitrendipine; Parasympatholytics; Phosphatidylinositols; Pyrroles; Trachea | 1992 |
The relaxant effects of cromakalim (BRL 34915) on human isolated airway smooth muscle.
Topics: Acetylcholine; Benzopyrans; Bronchi; Bronchodilator Agents; Cromakalim; Drug Interactions; Histamine; Humans; Isoproterenol; Muscle Relaxation; Muscle, Smooth; Pyrroles; SRS-A; Theophylline | 1992 |
Airway pharmacology of the potassium channel opener, HOE 234, in guinea pigs: in vitro and in vivo studies.
Topics: Animals; Benzopyrans; Bronchoconstrictor Agents; Bronchodilator Agents; Carbachol; Chromans; Cromakalim; Dinoprostone; Female; Guinea Pigs; Histamine; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Potassium Channels; Pyrroles; Pyrrolidines; Trachea | 1992 |
Smooth muscle relaxation and inhibition of responses to pinacidil and cromakalim induced by phentolamine in guinea-pig isolated trachea.
Topics: Animals; Benzopyrans; Carbachol; Cromakalim; Dinoprost; Female; Guanidines; Guinea Pigs; Histamine; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Phentolamine; Pinacidil; Pyrroles; SRS-A; Trachea | 1992 |
Evaluation of the potassium channel activator BRL 38227 as an inhaled bronchodilator in the guinea-pig: contrast with nifedipine and salbutamol.
Topics: Administration, Inhalation; Airway Resistance; Albuterol; Aminophylline; Animals; Benzopyrans; Bronchoconstriction; Bronchodilator Agents; Cromakalim; Drug Evaluation, Preclinical; Guinea Pigs; Histamine; Lung; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Potassium Channels; Pyrroles | 1991 |
Glibenclamide blocks the relaxant action of pinacidil and cromakalim in airway smooth muscle.
Topics: Animals; Benzopyrans; Cromakalim; Female; Glyburide; Guanidines; Guinea Pigs; Histamine; In Vitro Techniques; Male; Muscle Relaxants, Central; Muscle Relaxation; Muscle, Smooth; Pinacidil; Pyrroles; Terbutaline; Theophylline; Trachea; Verapamil | 1990 |
Endothelium-dependent and BRL 34915-induced vasodilatation in rat isolated perfused mesenteric arteries: role of G-proteins, K+ and calcium channels.
Topics: Acetylcholine; Animals; Benzopyrans; Calcimycin; Calcium Channel Blockers; Calcium Channels; Cromakalim; Endothelium, Vascular; GTP-Binding Proteins; Histamine; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide; Pertussis Toxin; Potassium Channels; Pyrroles; Rats; Vasodilator Agents; Virulence Factors, Bordetella | 1990 |
Electrical and mechanical effects of BRL34915 in guinea-pig isolated trachealis.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Benzopyrans; Cromakalim; Female; Guinea Pigs; Histamine; In Vitro Techniques; Ion Channels; Male; Membrane Potentials; Muscle Relaxation; Muscle, Smooth; Potassium Chloride; Pyrroles; Trachea | 1986 |
Effect of cromakalim on contractions in rabbit isolated renal artery in the presence and absence of extracellular Ca2+.
Topics: Animals; Benzopyrans; Caffeine; Calcium; Calcium Channel Blockers; Cromakalim; Guanidines; Guanylate Cyclase; Histamine; In Vitro Techniques; Lanthanum; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Nitroprusside; Norepinephrine; Pinacidil; Pyrroles; Rabbits; Renal Artery; Vasodilator Agents | 1989 |
Evaluation of the potassium channel activator cromakalim (BRL 34915) as a bronchodilator in the guinea-pig: comparison with nifedipine.
Topics: Animals; Benzopyrans; Bronchodilator Agents; Cromakalim; Guinea Pigs; Histamine; In Vitro Techniques; Male; Nifedipine; Ovalbumin; Potassium Channels; Pyrroles; Serotonin Antagonists; Trachea | 1988 |
Effects of the potassium channel openers cromakalim and pinacidil on catecholamine secretion and calcium mobilization in cultured bovine adrenal chromaffin cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenal Medulla; Animals; Barium; Benzopyrans; Bradykinin; Calcimycin; Calcium; Carbachol; Catecholamines; Cattle; Cells, Cultured; Cromakalim; Guanidines; Histamine; Pinacidil; Potassium; Potassium Channels; Pyrroles; Rubidium Radioisotopes | 1994 |
Antigen-induced airway responses are inhibited by a potassium channel opener.
Topics: Administration, Inhalation; Airway Resistance; Animals; Antigens; Benzopyrans; Blood Pressure; Bronchi; Bronchoconstriction; Bronchodilator Agents; Capillary Permeability; Cromakalim; Dimethyl Sulfoxide; Evans Blue; Guinea Pigs; Histamine; Histamine Release; Leukotriene D4; Lung; Male; Ovalbumin; Potassium Channels; Pyrroles | 1994 |
Involvement of K+ channels in the relaxant responses to various agonists in estrogen primed rat uterus.
Topics: Animals; Benzopyrans; Calcium; Cromakalim; Dose-Response Relationship, Drug; Epinephrine; Estrogens; Female; Guanidines; Histamine; Isoproterenol; Muscle Relaxation; Muscle, Smooth; Pinacidil; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Wistar; Uterine Contraction; Uterus; Vasodilator Agents | 1995 |
Effects of cromakalim on bradykinin-, histamine- and substance P-induced airway microvascular leakage in the guinea-pig.
Topics: Animals; Benzopyrans; Bradykinin; Bronchi; Capillary Permeability; Cromakalim; Electric Stimulation; Evans Blue; Female; Guinea Pigs; Histamine; In Vitro Techniques; Injections, Intravenous; Lung; Male; Muscle Contraction; Muscle, Smooth; Pyrroles; Respiratory System; Substance P; Trachea | 1993 |
Drug-induced endothelium-dependent and -independent relaxations in isolated resistance vessels taken from simultaneously hypertensive and streptozotocin-diabetic rats.
Topics: Animals; Benzopyrans; Bradykinin; Calcium; Cromakalim; Diabetes Mellitus, Experimental; Endothelium, Vascular; Glyburide; Histamine; Hypertension; Male; Mesenteric Arteries; Methacholine Chloride; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Nitroprusside; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Streptozocin; Vascular Resistance; Vasodilation; Vasodilator Agents | 1994 |
Effects of cromakalim (BRL 34915) in trachea isolated from actively sensitized guinea-pigs.
Topics: Acetylcholine; Animals; Benzopyrans; Bronchodilator Agents; Cromakalim; Female; Guinea Pigs; Histamine; Immunization; Kinetics; Male; Muscle Tonus; Muscle, Smooth; Potassium; Potassium Channels; Pyrroles; Serum Albumin, Bovine; Trachea | 1993 |
In vivo bronchodilator action of a novel K+ channel opener, KC 399, in the guinea pig.
Topics: Administration, Inhalation; Albuterol; Anesthesia; Animals; Antigens; Asthma; Benzopyrans; Bronchoconstriction; Bronchodilator Agents; Consciousness; Cromakalim; Disease Models, Animal; Guinea Pigs; Histamine; Immunization; Injections, Intravenous; Male; Potassium Channels; Pyrroles | 1994 |
Comparison of the airways relaxant and hypotensive potencies of the potassium channel activators BRL 55834 and levcromakalim (BRL 38227) in vivo in guinea-pigs and rats.
Topics: Administration, Oral; Aerosols; Airway Resistance; Animals; Benzopyrans; Blood Pressure; Bronchodilator Agents; Cromakalim; Dose-Response Relationship, Drug; Duodenum; Guinea Pigs; Histamine; Histamine Antagonists; Injections, Intravenous; Intubation, Gastrointestinal; Lung Compliance; Male; Methacholine Compounds; Piperidones; Pyrroles; Rats; Rats, Sprague-Dawley | 1993 |
Relaxant effects of the potassium channel activators BRL 38227 and pinacidil on guinea-pig and human airway smooth muscle, and blockade of their effects by glibenclamide and BRL 31660.
Topics: Animals; Anti-Arrhythmia Agents; Benzopyrans; Bronchi; Cromakalim; Female; Glyburide; Guanidines; Guinea Pigs; Histamine; Humans; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Pinacidil; Potassium; Potassium Channels; Potassium Radioisotopes; Pyrroles; Pyrrolidines; Respiratory System; Trachea; Vasodilator Agents | 1993 |
Regional differences in endothelium-dependent relaxation in the rat: contribution of nitric oxide and nitric oxide-independent mechanisms.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Aorta; Arginine; Benzopyrans; Calcimycin; Calcitonin Gene-Related Peptide; Cromakalim; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Female; Femoral Artery; Histamine; Ionophores; Liver; Mesenteric Arteries; Muscle, Smooth, Vascular; Nitric Oxide; Nitroarginine; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Rats; Rats, Sprague-Dawley; Renal Artery; Thromboxane A2; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 1995 |
The effect of inhaled K+ channel openers on bronchoconstriction and airway microvascular leakage in anaesthetised guinea pigs.
Topics: Administration, Inhalation; Animals; Benzopyrans; Blood Pressure; Bronchoconstriction; Bronchodilator Agents; Capillary Permeability; Chromans; Cromakalim; Female; Guinea Pigs; Histamine; Muscle Relaxants, Central; Potassium Channels; Pyrroles; Pyrrolidines; Vagus Nerve; Vasodilator Agents | 1996 |
Effect of the K+ channel openers NIP-121 and cromakalim on melittin-induced relaxation of guinea-pig isolated trachea.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Benzopyrans; Cromakalim; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Epithelium; Guinea Pigs; Histamine; Indomethacin; Leukotriene D4; Male; Melitten; Muscle Relaxation; Muscle, Smooth; Oxadiazoles; Phospholipases A; Phospholipases A2; Piperidines; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Thromboxane A2; Trachea | 1996 |
Anti-ulcer activity of cromakalim (BRL 34915), a potassium-channel opener, against experimentally induced gastric and duodenal ulcers in rats and guinea-pigs.
Topics: Animals; Aspirin; Benzopyrans; Cromakalim; Duodenal Ulcer; Female; Guinea Pigs; Histamine; Male; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Stomach Ulcer | 1997 |
Effects of JTV-506, a new K+ channel activator, on airway smooth muscle contraction and systemic blood pressure.
Topics: Animals; Benzopyrans; Blood Pressure; Bronchodilator Agents; Chromans; Cromakalim; Guinea Pigs; Histamine; In Vitro Techniques; Isometric Contraction; Male; Muscle Contraction; Muscle, Smooth; Potassium Channels; Pyrroles; Trachea | 1997 |
Pharmacological characteristics of MJ-451, a new benzopyran- derived ATP-sensitive potassium channel opener, in guinea pig isolated trachea.
Topics: Animals; Benzopyrans; Carbachol; Cromakalim; Drug Interactions; Female; Guinea Pigs; Histamine; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Parasympatholytics; Parasympathomimetics; Potassium Channels; Potassium Chloride; Pyrrolidinones; Trachea | 1998 |
Effects of cromakalim and glibenclamide on arteriolar and venular diameters and macromolecular leakage in the microcirculation during ischemia/reperfusion.
Topics: Adenosine Triphosphate; Animals; Arterioles; Capillary Permeability; Cheek; Cricetinae; Cromakalim; Dextrans; Fluorescein-5-isothiocyanate; Glyburide; Histamine; Ischemia; Lymphatic System; Male; Mesocricetus; Potassium Channel Blockers; Potassium Channels; Reperfusion Injury; Vasodilator Agents | 2002 |
Effects of ouabain on human bronchial muscle in vitro.
Topics: Acetylcholine; Bronchi; Calcium; Calcium Channel Blockers; Colforsin; Cromakalim; Histamine; Humans; In Vitro Techniques; Inositol Phosphates; Isoproterenol; Membrane Potentials; Muscle Relaxation; Muscle, Smooth; Nitroprusside; Ouabain; Protein Kinase C; Sodium Potassium Chloride Symporter Inhibitors; Sodium-Hydrogen Exchangers; Sodium-Potassium-Exchanging ATPase; Time Factors; Vasoconstrictor Agents; Vasodilator Agents | 2003 |
Pharmacological characterization of urinary bladder smooth muscle contractility following partial bladder outlet obstruction in pigs.
Topics: Adenosine Triphosphate; Amides; Animals; Benzophenones; Carbachol; Cholinergic Agonists; Cromakalim; Cyclic S-Oxides; Diazoxide; Dose-Response Relationship, Drug; Electric Stimulation; Female; Guanidines; Histamine; Hypertrophy; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Potassium Channels; Potassium Chloride; Pyridines; Quinolones; Serotonin; Serotonin Agents; Swine; Urinary Bladder; Urinary Bladder Neck Obstruction; Vasodilator Agents | 2006 |