cromakalim has been researched along with glyburide in 496 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (3.83) | 18.7374 |
| 1990's | 363 (73.19) | 18.2507 |
| 2000's | 94 (18.95) | 29.6817 |
| 2010's | 18 (3.63) | 24.3611 |
| 2020's | 2 (0.40) | 2.80 |
| Authors | Studies |
|---|---|
| Atwal, KS; Bryson, CC; Cohen, RB; Dickinson, KE; Grover, GJ; Lodge, NJ; Normandin, DE; Sleph, PG; Traeger, SC | 1 |
| Carroll, WA; Coghlan, MJ; Gopalakrishnan, M | 1 |
| Kreye, VA; Lenz, T; Pfründer, D; Theiss, U | 1 |
| Bray, K; Quast, U | 4 |
| de Hemptinne, A; Vanheel, B | 1 |
| D'Alonzo, AJ; Darbenzio, RB; Grover, GJ; Parham, CS | 1 |
| Galiñanes, M; Hearse, DJ; Shattock, MJ | 1 |
| Downing, SJ; Hollingsworth, M | 2 |
| Braida, C; Holzmann, S; Kukovetz, WR; Pöch, G | 1 |
| Okamoto, K; Sakai, Y; Sakuta, H; Sekiguchi, M | 1 |
| Cook, D; Stockbridge, N; Vollrath, B; Weir, B; Zhang, H | 1 |
| Kozlowski, RZ; Nye, PC; Robertson, BE | 1 |
| Edwards, G; Henshaw, M; Miller, M; Weston, AH | 1 |
| Asano, M; Ito, K; Kanno, T; Masuzawa-Ito, K; Ohashi, H; Suzuki, H; Suzuki, K; Takewaki, T | 1 |
| Akima, M; Imagawa, J; Nabata, H; Taira, N | 1 |
| Huang, TF; Ko, FN; Su, MJ; Teng, CM; Wang, ML; Wu, TS; Yu, SM | 1 |
| Edvinsson, L; Jansen, I; Nilsson, L | 1 |
| Deitmer, P; Golenhofen, K; Noack, T | 1 |
| Henderson, G; Hicks, GA | 1 |
| Racagni, G; Salvaggio, A; Tromba, C; Volterra, A | 1 |
| Kau, ST; Li, JH; Zografos, P | 1 |
| Abman, SH; Cornfield, DN; McMurtry, IF; McQueston, JA; Rodman, DM | 1 |
| Malik, AB; Pinheiro, JM | 1 |
| Kamijo, T; Kido, H; Miwa, A; Nakamura, F; Sugimoto, T; Tomaru, T; Uchida, Y | 1 |
| Alibhai, KN; Huizinga, JD; Richardson, D | 1 |
| Deitmer, P; Edwards, G; Noack, T; Weston, AH | 2 |
| Kato, H; Shimada, F; Takata, Y | 1 |
| Adams, DJ; Rusko, J; Tanzi, F; van Breemen, C | 1 |
| Bott, A; Eltze, M; Illes, P | 1 |
| Li, YQ; Triggle, CR; Wyse, DG | 1 |
| Fernandes, LB; Goldie, RG; Hay, DW; Muccitelli, RM; Page, CP; Preuss, JM; Spina, D | 1 |
| Clapham, JC; Good, DM; Hamilton, TC | 1 |
| Andersson, PO; Criddle, D; Deitmer, P; Edwards, G; Greengrass, P; Morita, T; Noack, T; Weston, AH; Wyllie, MG | 1 |
| Eckman, DM; Frankovich, JD; Keef, KD | 1 |
| Trezise, DJ; Weston, AH | 1 |
| Lau, WM | 1 |
| Brayden, JE; Uusitalo, H; Zschauer, A | 1 |
| Barbieri, A; Botta, L; Grana, E; Valli, P; Zucca, G | 1 |
| Silberberg, SD; van Breemen, C | 1 |
| Clapp, LH; Gurney, AM | 1 |
| Chopra, LC; Twort, CH; Ward, JP | 1 |
| Horacek, J; Lefebvre, RA | 1 |
| Aaronson, PI; Russell, SN; Smirnov, SV | 1 |
| Bowen, S; Carl, A; Gelband, CH; Hume, JR; Sanders, KM | 1 |
| Angel, I; Bidet, S | 1 |
| Ashford, ML; Ben-Ari, Y; Zini, S | 1 |
| Iwakami, N; Kojima, K; Sugai, T; Suzuki, Y | 1 |
| Charette, L; Garcia, ML; Jones, TR; Kaczorowski, GJ | 1 |
| Dzwonczyk, S; Grover, GJ; Sleph, PG | 1 |
| Longmore, J; Newgreen, DT; Weston, AH | 1 |
| Politi, DM; Rogawski, MA | 1 |
| Kovacs, RJ; Nelson, MT | 1 |
| Corrêa, DS; Rabetti, AC; Rae, GA | 1 |
| de Moura, RS; Jasbik, W | 1 |
| Calixto, JB; Guimarães, CL; Rae, GA | 1 |
| Hood, JS; Kadowitz, PJ; McMahon, TJ | 2 |
| Barbieri, A; Grana, E; Zonta, F | 1 |
| Cooper, J; Maclagan, J | 1 |
| Daniel, EE; Jury, J | 1 |
| Collins, P; Jiang, CW; Poole-Wilson, PA | 1 |
| Shikada, K; Tanaka, S; Yamamoto, A | 1 |
| Higuera, TR; Kadowitz, PJ; Kvamme, P; Minkes, RK; Nossaman, BD | 1 |
| Kreye, VA; Lenz, T; Theiss, U | 1 |
| Satoh, K; Taira, N; Yamada, H | 1 |
| Ksoll, E; Mackert, JR; Parsons, AA; Schilling, L; Wahl, M | 2 |
| Arakawa, C; Kasuya, Y; Masuda, Y; Miyajima, M; Shigenobu, K; Tanaka, S; Yamashita, T | 1 |
| de Weille, JR; Häusser, MA; Lazdunski, M | 1 |
| Brown, TJ; Raeburn, D | 1 |
| Jones, AW; Post, JM | 1 |
| Huang, Y; Langton, PD; Nelson, MT; Standen, NB | 1 |
| Farraway, L; Huizinga, JD | 1 |
| Hirano, K; Kanaide, H; Yoshitake, K | 1 |
| Cavero, I; Mondot, S; Montier, F; Pratz, J | 1 |
| Chapnick, BM; Pawloski, JR | 1 |
| Buckingham, RE; Campbell, CA; Clapham, JC; Gout, B; Hamilton, TC; Ilsley, GL; Longman, SD | 1 |
| Dunn, A; Sylvester, JT; Wiener, CM | 1 |
| Halpern, W; McCarron, JG; Nelson, MT; Quayle, JM | 1 |
| Angus, JA; McPherson, GA | 2 |
| Honoré, E; Lazdunski, M | 1 |
| Dzwonczyk, S; Grover, GJ; Sargent, CA; Sleph, PG; Smith, MA | 1 |
| Conder, ML; Dzwonczyk, S; Grover, GJ; McCullough, JR; Normandin, DE; Sleph, PG | 1 |
| Chang, CC; Hong, SJ | 1 |
| Greger, R; Kunzelmann, K; Lindeman, S; Lindeman, V; Pavenstädt, H; Späth, M | 1 |
| Daut, J; Goedel-Meinen, L; Günther, K; Maier-Rudolph, W; Mehrke, G; von Beckerath, N | 1 |
| Barnes, PJ; Ichinose, M | 1 |
| Hayashi, K; Hisaki, K; Matsumura, Y; Morimoto, S; Ohyama, T; Suzuki, Y; Yoshida, Y | 1 |
| Hu, SL; Kim, HS; Okolie, P; Weiss, GB | 1 |
| Bang, L; Brønsgaard, AM; Nielsen-Kudsk, JE | 1 |
| Asano, M; Masuzawa, K; Matsuda, T | 1 |
| Blaustein, MP; Rubin, LJ; Tod, ML; Yuan, XJ | 1 |
| Pilsudski, R; Rougier, O; Tourneur, Y | 1 |
| Miyata, N; Otomo, S; Tsuchida, K | 1 |
| Antoine, MH; Berkenboom, G; Fang, ZY; Fontaine, J; Herchuelz, A; Hermann, M; Lebrun, P | 1 |
| Asano, M; Imaizumi, Y; Masuzawa, K; Matsuda, T; Watanabe, M | 2 |
| Alouan, LA; Armour, CL; Barnes, PJ; Black, JL; Johnson, PR | 1 |
| McHarg, AD; Southerton, JS; Weston, AH | 1 |
| Antoine, MH; Devreux, V; Herchuelz, A; Hermann, M; Lebrun, P | 1 |
| Franke, C; Hatt, H; Quasthoff, S; Richter-Turtur, M | 1 |
| Downing, SJ; Hollingsworth, M; Minshall, E; Piper, I; Sadraei, H | 1 |
| Satoh, K; Taira, N; Yamada, H; Yoneyama, F | 1 |
| Taira, N; Teshigawara, T; Yanagisawa, T | 1 |
| Satoh, E; Taira, N; Yanagisawa, T | 1 |
| Satoh, K; Taira, N; Yoneyama, F | 1 |
| Bray, KM; Brown, BS; Duty, S; Edwards, G; Kay, PB; Longmore, J; McHarg, AD; Newgreen, DT; Southerton, JS; Weston, AH | 1 |
| Kaneko, K; Miyata, N; Otomo, S; Tanaka, M; Tsuchida, K | 1 |
| Cavero, I; Escande, D; Leguern, S; Thuringer, D | 1 |
| Sanguinetti, MC; Scott, AL; Siegl, PK; Zingaro, GJ | 1 |
| Baskin, EP; Garcia, ML; Heaney, LA; Kaczorowski, GJ; Stein, RB; Wallace, AA; Winquist, RJ | 1 |
| Eltze, M | 2 |
| Cavero, I; Mestre, M; Mondot, S | 1 |
| Buckingham, RE; Hamilton, TC; Howlett, DR; Mootoo, S; Wilson, C | 1 |
| Wilson, C | 1 |
| Cook, NS; Quast, U | 1 |
| Brayden, JE; Davies, NW; Huang, Y; Nelson, MT; Quayle, JM; Standen, NB | 1 |
| Sanguinetti, MC; Siegl, PK; Wolleben, CD | 1 |
| BoSmith, RE; Briggs, I; Grant, TL; Grimwood, S; Russell, NJ; Stone, MA; Wickenden, AD | 1 |
| Conder, ML; Grover, GJ; Henry, DE; McCullough, JR; Sleph, PG | 1 |
| Cavero, I; Courteix, J; Escande, D; Laville, M; Le Guern, S; Thuringer, D | 1 |
| Boyle, JP; Murray, MA; Small, RC | 1 |
| Longmore, J; Weston, AH | 1 |
| Bray, KM; Duty, S; Weston, AH | 1 |
| Hollingsworth, M; Piper, I | 1 |
| den Hertog, A; Nelemans, A; Van den Akker, J | 1 |
| Chae, SW; Cho, KP; Kang, HS; Kim, D; Kim, JS; Kwak, YG; Park, SK; Yoo, SE | 1 |
| D'Alonzo, AJ; Darbenzio, RB; Hess, TA; Sewter, JC | 1 |
| Kanwal, S; Trachte, GJ | 1 |
| Hong, KW; Lee, WS; Pyo, KM; Rhim, BY; Yu, SS | 1 |
| Satoh, H | 2 |
| Nabata, H; Suzuki, Y; Tamura, K; Yoshida, S | 1 |
| Kinoshita, M; Nakae, I; Quan, L; Sugimoto, Y; Tsutamoto, T | 1 |
| Bouchard, JF; Dumont, E; Lamontagne, D | 1 |
| Asano, M; Masuzawa-Ito, K; Matsuda, T | 1 |
| Allescher, HD; Franck, H; Puschmann, A; Schusdziarra, V | 1 |
| Maggi, CA; Meini, S; Santicioli, P | 1 |
| Ohkubo, T; Shibata, M | 1 |
| Kobayashi, D; Okabe, E; Ozono, S; Todoki, K | 1 |
| Abe, T; Arita, M; Saikawa, T; Sakata, T; Sato, T; Shigematsu, S | 1 |
| Ashcroft, FM; Davies, AG; Paterson, DJ; Reid, JM | 1 |
| Allen, DG; Duty, S | 1 |
| Clapp, LH | 1 |
| Khimenko, PL; Moore, TM; Taylor, AE | 1 |
| Mellemkjaer, S; Nielsen-Kudsk, JE | 2 |
| Do, ML; Empfield, JR; Halterman, TJ; Howe, BB; Ohnmacht, CJ; Pettinger, SJ; Russell, K; Stow, RB; Trainor, DA; Yochim, CL | 1 |
| Allard, B; Lazdunski, M; Rougier, O | 1 |
| Broadley, KJ; Ford, WR; Urquhart, RA | 1 |
| Groschner, K; Kühberger, E; Kukovetz, WR | 1 |
| Fukushima, H; Jinno, Y; Kaneta, S; Miwa, A; Ogawa, N | 1 |
| Ginkawa, M; Kontani, H; Sakai, T | 1 |
| Hirano, Y; Masuda, N; Satoh, N; Shirai, Y; Taguchi, T; Takenaka, T; Uchida, W | 1 |
| Kam, KL; Pfaffendorf, M; van Zwieten, PA | 2 |
| Atwal, KS; D'Alonzo, AJ; Grover, GJ; McCullough, JR; Sargent, CA | 1 |
| Dux, L; Ferdinandy, P; Koltai, M; Szilvássy, Z | 1 |
| Challinor-Rogers, JL; Iskander, MN; Kong, DC; McPherson, GA | 1 |
| Gonzalez de la Fuente, P; Marthan, R; Savineau, JP | 1 |
| Maggi, CA; Morbidelli, L; Parenti, A; Santicioli, P; Ziche, M | 1 |
| Parsons, AA; Schilling, L; Wahl, M | 2 |
| Chiba, S; Furukawa, Y; Murakami, M | 1 |
| Sakuta, H | 2 |
| Do, ML; Halterman, TJ; Howe, BB; Kau, ST; Li, JH; McConville, MW; Trivedi, S; Yochim, CL; Zografos, P | 1 |
| Bender, AS; White, HS; Woodbury, DM | 1 |
| Harada, K; Izawa, T; Jinno, Y; Miwa, A; Ogawa, N; Yokoyama, T | 1 |
| Imagawa, J; Kamei, K; Kuriyama, H; Nabata, H; Yoshida, S | 1 |
| Funada, M; Kamei, J; Kawashima, N; Misawa, M; Nagase, H; Narita, M; Suzuki, T; Takamori, K | 1 |
| Kamei, J; Kasuya, Y; Kawashima, N; Misawa, M; Narita, M; Suzuki, T | 1 |
| Akai, K; Kanatsuka, H; Komaru, T; Kumagai, T; Sato, K; Sekiguchi, N; Shirato, K; Sugimura, A; Wang, Y | 1 |
| Giuliani, S; Maggi, CA; Santicioli, P | 2 |
| Erdemli, G; Krnjević, K | 1 |
| Heath, BM; Terrar, DA | 1 |
| Daut, J; Klieber, HG | 1 |
| Harding, SE; Jiang, C; MacLeod, KT; Mochizuki, S; Poole-Wilson, PA | 1 |
| D'Alonzo, AJ; Darbenzio, RB; Grover, GJ; Hess, TA; Sewter, JC; Sleph, PG | 1 |
| Cyrys, S; Daut, J | 1 |
| Izawa, T; Jinno, Y; Miwa, A; Ogawa, N; Yokoyama, T | 1 |
| McPherson, GA; Piekarska, AE | 1 |
| Bonev, AD; Mawe, GM; Nelson, MT; Zhang, L | 1 |
| Head, SI; Hussain, M; Wareham, AC | 1 |
| Hou, YS; Lee, SS; Teng, CM; Yu, SM | 1 |
| Buchanan, LV; Cimini, MG; Gibson, JK; Khan, SA; Meisheri, KD; Norman, NR; Shebuski, RJ; Toombs, CF | 1 |
| Moore, TL; Shebuski, RJ; Toombs, CF | 1 |
| Akamatsu, S; Dohi, S; Iida, H; Ishiyama, T; Ohta, S; Shimonaka, H | 1 |
| Armstrong, JM; Bellemin-Baurreau, J; Hicks, PE; Poizot, A; Rochette, L | 1 |
| Bishop, BE; Doggrell, SA | 1 |
| Clapham, JC; Hamilton, TC; Trail, BK | 1 |
| Hashimoto, K; Kinoshita, M; Nakae, I; Quan, L; Sugimoto, Y; Tsutamoto, T | 1 |
| Addo, MF; Falotico, R; Giardino, E; Haertlein, BJ; Katz, LB; Loughney, D; McNally, JJ; Press, JB; Sanfilippo, PJ | 1 |
| Fukata, Y; Fukushima, H; Harada, K; Kasai, H; Ogawa, N | 1 |
| Alkadhi, KA; Salgado, D; Shek, EW | 1 |
| Fukata, Y; Fukushima, H; Jinno, Y; Kaneta, S; Ogawa, N; Okada, Y; Yokoyama, T | 1 |
| Fukushima, H; Izawa, T; Kashiwabara, T; Ogawa, N; Tanaka, Y; Yokoyama, T | 1 |
| Abe, S; Kanaide, H; Nakamura, M; Nishimura, J | 1 |
| Jinkawa, M; Kontani, H; Sakai, T | 1 |
| Eichinger, MR; Russ, RD; Walker, BR | 1 |
| Deutsch, N; Weiss, JN | 1 |
| Sakuta, H; Yoneda, I | 1 |
| Croxton, TL; Fernandes, LB; Hirshman, CA; Lindeman, KS | 1 |
| Jun, JY; Kim, KW; Kim, SJ | 1 |
| Brayden, JE; Conway, MA; Nelson, MT | 1 |
| Nielsen-Kudsk, JE; Thirstrup, S | 1 |
| Dzwonczyk, S; Grover, GJ; McCullough, JR; Sleph, PG | 1 |
| Khan, SA; Meisheri, KD; Ohrnberger, CE | 1 |
| Sargent, C; Smith, MA; Weselcouch, EO; Wilde, MW | 1 |
| Larach, DR; Schuler, HG | 1 |
| Jackson, WF | 1 |
| Mori, T; Satoh, K; Taira, N; Yamada, H | 1 |
| Beech, DJ; Bolton, TB; Nakao, K; Zhang, H | 1 |
| Garland, CJ; Plane, F | 1 |
| Mombouli, JV; Nakashima, M; Taylor, AA; Vanhoutte, PM | 1 |
| Das, DK; Engelman, RM; Szerdahelyi, P; Tosaki, A | 1 |
| Bonev, AD; Nelson, MT | 2 |
| Hellegouarch, A; Tosaki, A | 1 |
| Boachie-Anash, G; Henderson, CG; Kane, KA; Tweedie, D | 1 |
| Kamei, K; Kuriyama, H; Nabata, H | 1 |
| Edwards, G; Weston, AH | 1 |
| Edwards, G; Ibbotson, T; Weston, AH | 1 |
| Fukata, Y; Fukushima, H; Jinno, Y; Kaneta, S; Miwa, A; Ogawa, N | 1 |
| Nakaya, H | 1 |
| Finta, EP; Fischer, HD; Harms, L; Illes, P; Sevcik, J | 1 |
| Fukushima, H; Jinno, Y; Kaneta, S; Kasai, H; Miwa, A; Motoki, K; Ogawa, N; Okada, Y | 1 |
| Allard, B; Lazdunski, M | 1 |
| Cohen, GA; Hauth, TA; Hyman, AL; Lippton, HL | 1 |
| Freed, AN; Lindeman, KS | 1 |
| Bryan-Lluka, LJ; Vuocolo, HE | 1 |
| Hong, KW; Ko, KH; Park, MG; Rhim, BY; Shin, YW | 1 |
| Okamoto, K; Sakuta, H; Watanabe, Y | 1 |
| Iwamoto, Y; Kamei, J; Kasuya, Y; Misawa, M; Narita, M; Suzuki, T | 1 |
| Fattaccini, CM; Haj-Dahmane, S; Hamon, M; Lanfumey, L; Laporte, AM; Vantalon, V | 1 |
| Ko, FN; Lin, CH; Lu, ST; Teng, CM; Wu, YC | 1 |
| Brading, AF; Huang, SM; Katayama, N; Tomita, T | 1 |
| Cheuk, JM; Hollingsworth, M; Hughes, SJ; Maresh, MJ; Piper, IT | 1 |
| Okamoto, K; Sakuta, H | 1 |
| Marthan, R; Savineau, JP | 1 |
| Arch, JR; Bowring, NE; Buckle, DR; Foster, KA; Shaw, DJ; Taylor, JF; Taylor, SG | 1 |
| Bellan, JA; Kadowitz, PJ; Longenecker, LL; McNamara, DB | 1 |
| D'Aguinaga, S; de Mello, RF; de Moura, RS | 1 |
| Gu, H; Hagiwara, N; Momma, K; Nakanishi, T | 1 |
| Gelband, GH; McCullough, JR | 1 |
| Halaka, NN; Lodge, NJ | 1 |
| Okada, Y; Taira, N; Yanagisawa, T | 1 |
| Das, DK; Engelman, DT; Engelman, RM; Tosaki, A | 1 |
| Balderrama, DS; Eichinger, MR; Herrera, GM; Resta, JM; Resta, TC; Richardson, LA; Walker, BR | 1 |
| Kato, Y; Matsuda, T; Okazaki, K; Shigenobu, K; Tanaka, H | 1 |
| D'Alonzo, AJ; Darbenzio, RB; Grover, GJ; Hess, T; Sleph, PG | 1 |
| Droy-Lefaix, MT; Ferdinandy, P; Koltai, M; Szilvássy, Z; Tarrade, T | 1 |
| Abe, I; Fujii, K; Fujishima, M; Nagao, T; Ohya, Y; Setoguchi, M | 1 |
| de Lemos Neto, M; de Moura, RS | 1 |
| Hara, Y; Kimura, S; Kobayashi, S; Masuda, Y; Nakaya, H; Saito, T; Takizawa, T | 1 |
| Randall, MD | 1 |
| Baird, AJ; Grover, GJ; Sleph, PG | 1 |
| Hollingsworth, M; Hughes, SJ | 2 |
| Bolton, TB; Zhang, HL | 1 |
| Fabiani, ME; Story, DF | 1 |
| Brading, AF; Teramoto, N | 3 |
| Kelly, E; Kumar, P; Poucher, SM; Prior, H; Russell, K; Wickenden, AD | 1 |
| O'Brien, E; Wanstall, JC | 1 |
| French, RJ; Giles, WR; Han, X; Light, PE | 1 |
| Bennett, T; Fallgren, B; Gardiner, SM; Kemp, PA; March, JE | 1 |
| Boev, KK; Duridanova, DB | 1 |
| Kaneto, H; Nakao, K; Takahashi, M | 1 |
| Advenier, C; Bakdach, H; Bonnet, PA; Cui, YY; Michel, A; Naline, E | 1 |
| Hashii, M; Higashida, H; Ito, Y; Katsumori, H; Minabe, Y | 1 |
| Das, DK; Engelman, RM; Tosaki, A | 1 |
| Chujo, M; Hori, M; Inoue, M; Kamada, T; Kitakaze, M; Komamura, K; Minamino, T; Mori, H; Node, K; Shinozaki, Y | 1 |
| Bonev, A; Heppner, TJ; Kau, ST; Li, JH; Nelson, MT | 1 |
| Calixto, JB; Cechinel-Filho, V; Paulino, N; Yunes, RA | 1 |
| Gidday, JM; Maceren, RG; Meier, JA; Shah, AR; Zhu, Y | 1 |
| Angus, JA; Fujiwara, T | 1 |
| Hüsken, BC; Pfaffendorf, M; Timmenga, EJ; Van Zwieten, PA; Vroom, MB | 1 |
| Cox, BF; Perrone, MH; Smits, GJ | 1 |
| Hüsken, BC; Pfaffendorf, M; van Zwieten, PA | 1 |
| Bianchi, L; Boselli, C; Grana, E | 1 |
| Adler-Graschinsky, E; Feleder, EC | 1 |
| Flavahan, NA; Liu, Q | 1 |
| Bizub, DM; Gauthier-Rein, KM; Lombard, JH; Rusch, NJ | 1 |
| Aguggini, G; Dimori, M; Hussain, SN; Vanelli, G | 1 |
| Murray, PA; Nakayama, M; Sato, K; Seki, S | 1 |
| Brading, AF; McMurray, G; Teramoto, N | 1 |
| Haddad, GG; Jiang, C | 1 |
| Anthony, DM; Buckett, WR; Dickinson, K; Jones, RB; Kaul, CL; Marita, AR | 1 |
| Baczkó, I; Leprán, I; Papp, JG | 1 |
| Choi, RT; Iskander, MN; Kong, DC; McPherson, GA | 1 |
| Huang, Y; Kwok, KH | 1 |
| Adams, DJ; Katnik, C | 1 |
| Matsumura, K; Mochizuki-Oda, N; Oosawa, Y; Takeuchi, Y; Watanabe, Y | 1 |
| Deslauriers, R; Docherty, JC; Gunter, HE; Kuzio, B; Shoemaker, L; Yang, L | 1 |
| Chuliá, S; D'Ocon, P; Ivorra, MD; Noguera, MA | 1 |
| Kinoshita, M; Liu, Q; Matsumoto, T; Nakae, I; Omura, T; Takahashi, M; Takaoka, A | 1 |
| Hosoki, K; Karasawa, T; Nagata, S; Takeyama, K | 1 |
| Akar, F; Aşlamaci, S; Kanzik, I; Köksoy, C; Tufan, H; Uydeş-Dogan, BS | 1 |
| Champion, HC; Kadowitz, PJ | 1 |
| Boels, PJ; Deutsch, J; Gao, B; Haworth, SG | 1 |
| Brading, AF; Creed, KE; Teramoto, N | 1 |
| Deutsch, NA; Goldhaber, JI; Khuu, K; Lamp, ST; Shivkumar, K; Weiss, JN | 1 |
| Horibe, M; Murray, PA; Seki, S | 1 |
| Fujii, K; Fujishima, M; Ibayashi, S; Kitazono, T; Nagao, T; Toyoda, K | 1 |
| De Weille, JR; Lauritzen, I; Lazdunski, M | 1 |
| Higuchi, M; Kayo, S; Miyagi, K; Sakanashi, M | 1 |
| Fullerton, DA; McIntyre, RC; Meldrum, DR; Sheridan, BC | 1 |
| Kubo, M; Quayle, JM; Standen, NB | 1 |
| Hambrock, A; Kickenweiz, E; Krippeit-Drews, P; Metzger, F; Quast, U; Russ, U | 1 |
| Bojić, M; Djukanović, B; Gojkoviíc Bukarica, L; Kazić, T; Panić, G; Perić, M; Sajić, Z | 1 |
| Kato, Y; Matsuda, T; Noguchi, K; Okazaki, K; Saito, W; Shigenobu, K; Tanaka, H | 1 |
| Gambaryan, S; Jensen, BL; Kurtz, A; Scholz, H | 1 |
| Cook, MA; Gan, XT; Karmazyn, M; Moffat, MP | 1 |
| Cho, TS; Jung, YS; Moon, CH; Shin, HS; Yoo, SE | 1 |
| Saito, K; Sakai, K | 3 |
| Cogolludo, AL; Pérez-Vizcaíno, F; Tamargo, J; Villamor, E | 1 |
| Bartolini, A; Galeotti, N; Ghelardini, C | 1 |
| Barrett-Jolley, R; McPherson, GA | 1 |
| Akima, M; Saito, K; Sakai, K | 1 |
| Bankers-Fulbright, JL; Bradford, AL; Gleich, GJ; Kephart, GM; Kita, H; Loegering, DA; Okada, S | 1 |
| Aida, M; Saito, W; Saito, Y; Sasaki, M; Shigenobu, K; Tanaka, H; Tanaka, Y | 1 |
| Bryan, RM; Pelligrino, DA; Wang, Q | 1 |
| Kourie, JI | 1 |
| Deka, DK; Mishra, SK; Raviprakash, V | 1 |
| Ashraf, M; Miyawaki, H; Wang, Y | 1 |
| Motohashi, O; Sugai, K; Suzuki, M; Yanagisawa, T; Yoshimoto, T | 1 |
| Armstead, WM | 1 |
| Astier, A; Baufreton, C; Brunet, S; Fernandez, C; Kirsch, M; Loisance, DY; Pasteau, F | 1 |
| Bradley, KK; Horowitz, B; Keef, KD; Koh, SD; Rae, MG; Sanders, KM | 1 |
| Guo, ZG; Shi, DH | 1 |
| Karle, CA; Kreye, VA; Yao, X | 1 |
| Chang, IY; Jun, JY; Kim, KW; Kim, SJ; Yeum, CH; Yoon, PJ | 1 |
| Aguilar-Bryan, L; Babenko, AP; Bryan, J; Gonzalez, G | 1 |
| Bryan, PT; Marshall, JM | 1 |
| Balfagón, G; Ferrer, M; Marín, J; Tejera, N | 1 |
| Chagneau, C; De Gottardi, A; Fléjou, JF; Fouassier, L; Housset, C; Lahaye, P; Lebrec, D; Moreau, R; Reichen, J; Rona, JP; Tazi, KA | 1 |
| Kwan, YW; Lau, WM; To, KW; Tsang, SH | 1 |
| Brading, AF; Ito, Y; Teramoto, N | 1 |
| Chesnay, F; Duval, D; Gérard, JL; Picard, S; Rouet, R | 1 |
| de Vroomen, M; Gournay, V; Heymann, MA; Roman, C; Rudolph, AM; Takahashi, Y | 1 |
| Cobbe, SM; Hicks, MN; Kane, KA; Wolk, R | 1 |
| Huang, Y; Lau, CW | 1 |
| Beech, DJ; Prior, HM; Yates, MS | 1 |
| Kang, SY; Kim, MJ; Kim, ND; Park, JH; Schini-Kerth, VB | 1 |
| Brioni, JD; Sullivan, JP; Zhu, DX | 1 |
| Cogolludo, AL; Fajardo, S; Ibarra, M; Pérez-Vizcaíno, F; Tamargo, J | 1 |
| Abe, T; Arita, M; Kiyosue, T; Saikawa, T; Sakata, T; Sato, T | 1 |
| Hatano, Y; Ishikawa, T; Kinoshita, H | 1 |
| Faraci, FM; Sobey, CG | 1 |
| Brioni, JD; Gopalakrishnan, M; Miller, TR; Molinari, EJ; Monteggia, LM; Scott, VE; Sullivan, JP; Taber, RD; Whiteaker, KL | 1 |
| Quast, U; Rauch, U; Russ, U | 1 |
| Ito, Y; Teramoto, N | 1 |
| Chen, SJ; Wu, CC; Yen, MH | 1 |
| Carpenter, E; Peers, C; Roberts, ML; Taylor, SC | 1 |
| Abban, G; Akar, F; Buharalioğlu, CK; Heinemann, A; Holzer, P; Uydeş-Doğan, BS; Van de Voorde, J | 1 |
| Böhm-Pinger, MM; Dittrich, M; Fischer, IR; Fleischmann, BK; Gryshchenko, O; Hescheler, J; Igelmund, P; Soest, J; Viatchenko-Karpinski, S | 1 |
| Dun, W; Hao, YB; Shen, LH; Wu, YX; Yang, SP; Zhang, Y | 1 |
| Autore, G; d'Emmanuele di Villa Bianca, R; Lippolis, L; Pinto, A; Sorrentino, L; Sorrentino, R | 1 |
| Imaizumi, Y; Muraki, K; Tokuno, T; Watanabe, M | 1 |
| Chwalisz, K; Garfield, RE; Longo, M; Okawa, T; Olson, GL; Saade, GR; Vedernikov, YP | 1 |
| Gojković-Bukarica, L; Kazić, T | 1 |
| Baertschi, AJ; Baron, A; Monnier, D; Roatti, A; van Bever, L | 1 |
| Foldes, FF; Matkó, I; Nagashima, H; Oe, K; Sántha, E; Sperlágh, B; Vizi, ES | 1 |
| Jow, B; Numann, R | 1 |
| Cheng, CY; Lee, YM; Peng, YY; Sheu, JR; Yen, MH | 1 |
| Lohmann, AB; Welch, SP | 1 |
| Abe, K; Inoue, R; Ito, Y; Morita, H; Yamada, K | 1 |
| Brochu, M; Cadorette, C; Sicotte, B; St-Louis, J | 1 |
| Hatano, Y; Iranami, H; Iwahashi, S; Kakutani, T; Kinoshita, H; Mizumoto, K | 1 |
| Cordeiro, JM; French, RJ; Light, PE | 1 |
| Gambino, A; Thomas, BJ; Wanstall, JC | 1 |
| Asano, T; Dohi, S; Iida, H | 1 |
| Ito, Y; Nakashima, T; Teramoto, N | 1 |
| Hiley, CR; White, R | 1 |
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| Gupta, S; Irani, AN; Malhi, H; McDonald, TV; Rajvanshi, P; Spray, DC; Suadicani, SO | 1 |
| Chen, JY; Dafny, N; Kang, YM; Ouyang, W; Qiao, JT | 1 |
| Bottrill, FE; Hiley, CR; Omar, R; White, R | 1 |
| Damron, DS; Doi, S; Horibe, M; Murray, PA; Ogawa, K; Tanaka, S | 1 |
| Bell, K; Favaloro, J; Iskander, MM; Khalil, V; McPherson, GA | 1 |
| Mason, E; Pernat, A; Sun, S; Tang, W; Weil, MH | 1 |
| Tiritilli, A | 1 |
| Ito, Y; Masaki, I; Sueishi, K; Takano, M; Tanaka, K; Teramoto, N; Yonemitsu, Y; Yunoki, T | 1 |
| Clapp, LH; Jabr, RI; Wilson, AJ | 1 |
| Gold, PE; Stefani, MR | 1 |
| Bernhart, E; Koidl, B; Lang, P; Mächler, H; Pelzmann, B; Rigler, B; Schaffer, P | 1 |
| Hatano, Y; Iranami, H; Kakutani, T; Kinoshita, H | 1 |
| Ismail, JA; McDonough, KH | 1 |
| Bonev, AD; Heppner, TJ; Herrera, GM; Nelson, MT; Petkov, GV | 1 |
| Brading, AF; Ito, Y; Masaki, I; Sueishi, K; Takano, M; Teramoto, N; Yonemitsu, Y; Yunoki, T | 1 |
| Atwal, KS; Bajgar, R; D'Alonzo, AJ; Darbenzio, RB; Garlid, KD; Grover, GJ; Hess, TA; Lodge, NJ; Paucek, P; Sleph, PG; Smith, MA | 1 |
| Ikeda, S; Kyotani, S; Min, KY; Mori, H; Nagaya, N; Nakanishi, N; Ninomiya, I; Oya, H; Shimouchi, A; Shirai, M | 1 |
| Bajgar, R; Garlid, KD; Kowaltowski, AJ; Paucek, P; Seetharaman, S | 1 |
| Ambalavanan, N; Bulger, A; Philips, J; Ware, J | 1 |
| Adams, DJ; Hogg, RC | 1 |
| Coronel, R; de Groot, JR; de Jong, JW; Fiolet, JW; Remme, CA; Schumacher, CA; Wilde, AA | 1 |
| Edwards, G; Félétou, M; Gardener, MJ; Glen, CD; Richards, GR; Vanhoutte, PM; Weston, AH | 1 |
| Chen, IJ; Chiang, LC; Lin, CY; Lin, RJ; Shen, KP; Wu, BN | 1 |
| Brown, RA; Petrovski, P; Ren, J; Savage, AO | 1 |
| Imai, T; Koike, K; Okamoto, T; Shigenobu, K; Tanaka, H; Tanaka, Y; Yamamoto, Y | 1 |
| Clapp, LH; Cui, Y; Tinker, A; Tran, S | 1 |
| Reshef, A; Sperling, O; Zoref-Shani, E | 1 |
| Bouskela, E; Simões, C; Svensjö, E | 1 |
| McCurrie, JR; Wood, D; Yeung, CK | 1 |
| Han, J; Joo, H; Kim, E; Kim, N; Park, J; Seog, DH | 1 |
| Englert, H; Kilbinger, H; Krause, A; Mang, CF; Wirth, K | 1 |
| Christ, GJ; Giraldi, A; Melman, A; Spektor, M; Venkateswarlu, K; Wang, HZ; Zhao, W | 1 |
| Goyal, RK; Kulkarni, JS; Metha, AA; Santani, DD | 1 |
| Ahmed, R; Bird, NC; Chess-Williams, R; Johnson, AG | 1 |
| Auclair, J; Bouskela, E; Félétou, M; Levens, N; Néliat, G; Ravel, D | 1 |
| Dojo, M; Hatano, Y; Iranami, H; Kimoto, Y; Kinoshita, H; Nakahata, K | 2 |
| Csonka, C; Csont, T; Ferdinandy, P; Onody, A | 1 |
| Jung, SJ; Kim, J; Kwak, J; Lim, W; Park, YK; Yoo, JE | 1 |
| Al-Mehdi, AB; Chatterjee, S; Fisher, AB; Levitan, I; Stevens, T | 1 |
| Höhn, J; Krassói, I; Kun, A; Papp, JG; Pataricza, J | 1 |
| Fabiani, ME; Story, DF; Vlahos, R | 1 |
| Busija, DW; Horiguchi, T; Kis, B; Nagy, K; Rajapakse, NC; Snipes, JA | 1 |
| Endre, ZH; Gobé, GC; Rahgozar, M; Willgoss, DA | 1 |
| Dora, KA; Garland, CJ; Spitaler, MM; Takano, H | 1 |
| Boccara, G; Coriat, P; Le Cosquer, P; Lecomte, P; Mouren, S; Ouattara, A; Riou, B; Souktani, R | 1 |
| Ito, Y; Teramoto, N; Zhu, HL | 1 |
| Benedito, S; García, P; García-Sacristán, A; Hernández, M; Prieto, D; Recio, P; Rivera de los Arcos, L; Ruiz Rubio, JL | 1 |
| Dubrovska, G; Essin, K; Gollasch, M; Huang, Y; Luft, FC; Tsang, SY; Verlohren, S | 1 |
| Antunes, E; de Miranda Cará, A; De Nucci, G; Fregonesi, A; Rodrigues Netto, N | 1 |
| Aalkjaer, C; Forman, A; Glavind-Kristensen, M; Hansen, VB; Matchkov, V; Nilsson, H | 1 |
| Ghosh, M; Hanna, ST; McNeill, JR; Wang, R | 1 |
| Hambrock, A; Kayar, T; Osswald, H; Stumpp, D | 1 |
| Hong, SJ; Liang, HC; Shen, CJ | 1 |
| Katayama, T; Kitahata, H; Oshita, S; Tomiyama, Y; Yamaguchi, M | 1 |
| Gozalov, A; Jansen-Olesen, I; Klaerke, D; Mortensen, C; Olesen, J; Petersen, KA | 1 |
| Avshalumov, MV; Chen, BT; Koós, T; Rice, ME; Tepper, JM | 1 |
| Ghafar, R; Gilani, AH; Jabeen, Q; Khan, AU; Subhan, F | 1 |
| Clapp, LH; Fry, CH; Orie, NN | 1 |
| Graves, JE; Kooy, NW; Lewis, SJ | 1 |
| Ito, Y; Naito, S; Teramoto, N; Tomoda, T; Yunoki, T | 1 |
| Conte Camerino, D; Desai, RR; George, AL; Lundquist, AL; Mele, A; Tricarico, D | 1 |
| Ito, Y; Teramoto, N; Tomoda, T; Yunoki, T | 1 |
| Kobayashi, K; Kobayashi, M; Kojima, M; Maruyama, I; Maruyama, K; Ojima, K; Shibata, N; Tomiyama, Y; Yamazaki, Y | 1 |
| Baskurt, OK; Meiselman, HJ; Ozdem, SS; Usta, C; Yalcin, O | 1 |
| Bagcivan, I; Kaya, T; Turan, M; Yildirim, MK | 1 |
| Bigat, Z; Eksert, B; Gölbasi, I; Ozdem, SS; Usta, C | 1 |
| Chan, P; Kwan, YW; Lam, FF; Seto, SW; Yeung, JH | 1 |
| Kawahito, S; Kawano, T; Kitahata, H; Nakamura, A; Nakaya, Y; Nazari, H; Oshita, S; Takahashi, A | 1 |
| Ari, N; Aslamaci, S; Irat, AM; Karasu, C | 1 |
| Kathirvel, K; Parija, SC; Sardar, KK; Vijayakumar, C | 1 |
| Al Abed, A; Brock, JA; Tan, JH | 1 |
| Asadi, S; Dehpour, AR; Ebrahimi, F; Ghasemi, M; Hajrasouliha, AR; Sadeghipour, H; Shafaroodi, H; Tavakoli, S | 1 |
| Exintaris, B; Lang, RJ; Nguyen, DT | 1 |
| Chang, KC; Cho, HC; Chung, YK; Lee, HK; Lee, JW; Park, KE; Shin, IW; Sohn, JT | 1 |
| Dinc, M; Oz, M; Shippenberg, TS; Yang, KH | 1 |
| Budni, J; Gadotti, VM; Kaster, MP; Rodrigues, AL; Santos, AR | 1 |
| Asadi, S; Dehpour, AR; Ghasemi, M; Sadeghipour, H | 1 |
| Chen, X; Connors, SG; Mendonca, M; Patel, K; Welch, WJ; Wilcox, CS | 1 |
| Buck, LT; Cooray, M; Pamenter, ME; Shin, DS | 1 |
| Camerino, DC; Camerino, GM; Carbonara, G; Fracchiolla, G; Laghezza, A; Loiodice, F; Mele, A; Tortorella, P; Tricarico, D | 1 |
| Aras-López, R; Balfagon, G; Blanco-Rivero, J; Cobeño, L; Cogolludo, A; Ferrer, M; Gamallo, C; Pérez-Vizcaino, F | 1 |
| Catacuzzeno, L; Fioretti, B; Franciolini, F; Harper, A; Sforna, L; Trequattrini, C | 1 |
| Asano, H; Brading, AF; Kajioka, S; Naito, S; Nakayama, S; Seki, N | 1 |
| Azma, T; Hatakeyama, N; Hatano, Y; Iranami, H; Kaba, H; Kinoshita, H; Kuroda, Y; Matsuda, N; Nakahata, K; Tange, K | 1 |
| Carter, CB; Dearman, JA; Hester, RL; Hodnett, BL; Xiang, L | 1 |
| Dehpour, AR; Ebrahimi, F; Ghasemi, M; Gholipour, T; Karimollah, AR; Nezami, BG; Shafaroodi, H | 1 |
| Dimitriadis, F; Kinoshita, Y; Ohmasa, F; Saito, M; Satoh, I; Satoh, K; Shimizu, S; Taniguchi, S | 1 |
| Choudhury, S; Garg, SK; Mishra, SK; Singh, TU | 1 |
| Breschi, MC; Calderone, V; Cecchetti, V; Martelli, A; Sabatini, S; Testai, L | 1 |
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| Dimitriadis, F; Kinoshita, Y; Kitatani, K; Ohmasa, F; Oiwa, H; Saito, M; Satoh, K; Shomori, K; Tsounapi, P | 1 |
| Ishii, K; Moriuchi, H; Nakahara, T; Sakamoto, K; Yunoki, M | 1 |
| Jamal Mustafa, S; Ledent, C; Nayeem, MA; Ponnoth, DS; Tilley, SL | 1 |
| Balus, SF; Buelow, MW; Delaney, M; Dondlinger, L; Hoeppner, C; Lombard, JH; McEwen, ST; Priestley, JR; Weinberg, BD | 1 |
| Clemmer, JS; Gowdey, AR; Hester, RL; Lu, S; Mittwede, PN; Xiang, L | 1 |
| Holstein-Rathlou, NH; Jensen, LJ; Ngo, AT; Riemann, M; Torp-Pedersen, C | 1 |
| Bencsik, P; Csonka, C; Csont, T; Ferdinandy, P; Görbe, A; Kupai, K; Pálóczi, J; Puskás, LG; Zvara, A | 1 |
| Javid, FA; Palea, S | 1 |
| Honda, M; Inoue, K; Martin, DT; Oikawa, R; Saito, M; Sejima, T; Shimizu, S; Shimizu, T; Tanaka, K; Tomita, S; Tsounapi, P | 1 |
| Nakashima, M; Obata, T | 1 |
| Amiri, S; Azhand, P; Bakhtiarian, A; Foroohandeh, M; Motevalian, M; Nikoui, V; Ostadhadi, S; Sharifi, AM; Zolfaghari, S | 1 |
| Dehpour, AR; Moradi, A; Nikoui, V; Ostadhadi, S; Zolfaghari, S | 1 |
| Al-Karagholi, MA; Amin, FM; Ansari, A; Ashina, M; Ghanizada, H; Gram, C; Larsson, HB; Nielsen, CAW; Skovgaard, LT; Vestergaard, MB; Younis, S | 1 |
| Ahn, SH; Bae, SI; Hwang, Y; Kang, D; Lee, SH; Ok, SH; Park, JK; Park, KE; Sim, G; Sohn, JT | 1 |
| Andres, H; Bray, K; Manley, PW; Quast, U | 1 |
| Aguilar-Bryan, L; Bryan, J; Clement, JP; Gonoi, T; Inagaki, N; Seino, S; Wang, CZ | 1 |
| Atwal, KS; Ferrara, FN; Green, DW; Grover, GJ; Monshizadegan, H; Rogers, WL; Sleph, P; Traeger, S; Wang, P | 1 |
3 review(s) available for cromakalim and glyburide
| Article | Year |
|---|---|
Recent developments in the biology and medicinal chemistry of potassium channel modulators: update from a decade of progress.
Topics: Adenosine Triphosphate; Angina Pectoris; Arrhythmias, Cardiac; Asthma; Calcium; Ion Channel Gating; Myocardial Ischemia; Potassium Channel Blockers; Potassium Channels; Urinary Incontinence | 2001 |
[Potential role of ATP-sensitive K+ channels in ischemia- and reperfusion-induced arrhythmias].
Topics: Action Potentials; Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Benzopyrans; Cromakalim; Glyburide; Guanidines; Humans; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Niacinamide; Nicorandil; Pinacidil; Potassium; Potassium Channels; Pyrroles; Tolbutamide | 1993 |
Pharmacological and molecular characterization of ATP-sensitive K+ channels in the TE671 human medulloblastoma cell line.
Topics: Adenosine Triphosphate; Animals; Barbiturates; Cells, Cultured; Cromakalim; Fluorescent Dyes; Fluorometry; Glipizide; Glyburide; Humans; Insulinoma; Isoxazoles; Medulloblastoma; Membrane Potentials; Muscle, Smooth; Parasympatholytics; Potassium Channels; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured | 1999 |
1 trial(s) available for cromakalim and glyburide
| Article | Year |
|---|---|
Cerebrovascular effects of glibenclamide investigated using high-resolution magnetic resonance imaging in healthy volunteers.
Topics: Adult; Cerebral Arteries; Cerebrovascular Circulation; Cromakalim; Cross-Over Studies; Double-Blind Method; Female; Glyburide; Healthy Volunteers; Humans; KATP Channels; Magnetic Resonance Imaging; Male; Young Adult | 2021 |
492 other study(ies) available for cromakalim and glyburide
| Article | Year |
|---|---|
Binding of ATP-sensitive potassium channel (KATP) openers to cardiac membranes: correlation of binding affinities with cardioprotective and smooth muscle relaxing potencies.
Topics: Animals; ATP-Binding Cassette Transporters; Cardiotonic Agents; Dogs; KATP Channels; Muscle Relaxation; Muscle, Smooth; Myocardium; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Binding; Structure-Activity Relationship | 1998 |
Pharmacological characterization of nicorandil by 86Rb efflux and isometric vasorelaxation studies in vascular smooth muscle.
Topics: Animals; Aorta; Benzopyrans; Cromakalim; Glyburide; In Vitro Techniques; Niacinamide; Nicorandil; Nitroprusside; Potassium Channels; Pyrroles; Rabbits; Rubidium Radioisotopes; Vasodilation; Vasodilator Agents | 1992 |
Differences in the K(+)-channels opened by cromakalim, acetylcholine and substance P in rat aorta and porcine coronary artery.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Arginine; Benzopyrans; Coronary Vessels; Cromakalim; Endothelium, Vascular; Glyburide; Male; omega-N-Methylarginine; Potassium; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Substance P; Swine | 1991 |
Influence of KATP channel modulation on net potassium efflux from ischaemic mammalian cardiac tissue.
Topics: Action Potentials; Animals; Barium; Benzopyrans; Cromakalim; Glyburide; Guinea Pigs; Hydrogen-Ion Concentration; Muscles; Myocardial Ischemia; Oxygen; Papillary Muscles; Potassium; Potassium Channels; Pyrroles; Tolbutamide; Vasodilator Agents | 1992 |
Effects of intracoronary cromakalim on postischaemic contractile function and action potential duration.
Topics: Action Potentials; Animals; Benzopyrans; Blood Pressure; Coronary Circulation; Coronary Vessels; Cromakalim; Dogs; Glyburide; Myocardial Contraction; Myocardial Ischemia; Pyrroles; Vasodilator Agents | 1992 |
Effects of potassium channel modulation during global ischaemia in isolated rat heart with and without cardioplegia.
Topics: Animals; Benzopyrans; Blood Pressure; Coronary Circulation; Coronary Vessels; Cromakalim; Glyburide; Heart Arrest, Induced; Myocardial Contraction; Myocardial Ischemia; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Vasodilator Agents | 1992 |
One way cross tolerance between cromakalim and salbutamol in the uterus of the rat in vivo.
Topics: Albuterol; Animals; Benzopyrans; Cromakalim; Cyclic AMP; Drug Interactions; Drug Tolerance; Female; Glyburide; Muscle Relaxation; Propranolol; Pyrroles; Radioimmunoassay; Rats; Uterus | 1992 |
Pharmacological interaction experiments differentiate between glibenclamide-sensitive K+ channels and cyclic GMP as components of vasodilation by nicorandil.
Topics: Animals; Benzopyrans; Cattle; Coronary Vessels; Cromakalim; Cyclic GMP; Drug Interactions; Glyburide; Guanidines; In Vitro Techniques; Methylene Blue; Molsidomine; Muscle Relaxation; Niacinamide; Nicorandil; Nitroprusside; Pinacidil; Potassium Channels; Pyrroles; Sensitivity and Specificity; Vasodilator Agents | 1992 |
Inactivation of glibenclamide-sensitive K+ channels in Xenopus oocytes by various calmodulin antagonists.
Topics: Animals; Benzopyrans; Calmodulin; Cromakalim; Cyclic AMP; Female; Glyburide; In Vitro Techniques; Isoproterenol; Oocytes; Potassium Channels; Pyrroles; Up-Regulation; Xenopus | 1992 |
Vasodilatation of canine cerebral arteries by nicorandil, pinacidil and lemakalim.
Topics: Animals; Basilar Artery; Benzopyrans; Cerebral Arteries; Cromakalim; Dogs; Female; Glyburide; Guanidines; Guanylate Cyclase; In Vitro Techniques; Male; Methylene Blue; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Vasodilation; Vasodilator Agents | 1992 |
Opposing actions of tolbutamide and glibenclamide on hypoxic pulmonary vasoconstriction.
Topics: Animals; Benzopyrans; Cromakalim; Diazoxide; Glyburide; Hypoxia; In Vitro Techniques; Lung; Male; Potassium Channels; Pyrroles; Rats; Tolbutamide; Vasoconstriction | 1992 |
Comparison of the effects of several potassium-channel openers on rat bladder and rat portal vein in vitro.
Topics: Animals; Benzopyrans; Cromakalim; Glyburide; Guanidines; In Vitro Techniques; Male; Pinacidil; Portal Vein; Potassium; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Urinary Bladder | 1991 |
Effects of cromakalim on the contraction and the membrane potential of the circular smooth muscle of guinea-pig stomach.
Topics: Acetylcholine; Animals; Benzopyrans; Charybdotoxin; Cromakalim; Electric Stimulation; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Microelectrodes; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Parasympatholytics; Pyrroles; Scorpion Venoms; Stomach | 1992 |
Spasmolytic action of nicorandil in canine conductive coronary arteries in vivo is not modified by glibenclamide.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Angiocardiography; Animals; Benzopyrans; Coronary Circulation; Coronary Vasospasm; Coronary Vessels; Cromakalim; Dogs; Female; Glyburide; Male; Niacinamide; Nicorandil; Nitroglycerin; Parasympatholytics; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Vasodilator Agents | 1992 |
Vasorelaxing effect in rat thoracic aorta caused by fraxinellone and dictamine isolated from the Chinese herb Dictamnus dasycarpus Turcz: comparison with cromakalim and Ca2+ channel blockers.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alkaloids; Animals; Aorta, Thoracic; Benzofurans; Benzopyrans; Calcium; Calcium Channel Blockers; Cromakalim; Cyclic AMP; Cyclic GMP; Drugs, Chinese Herbal; Female; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Potassium Channels; Potassium Chloride; Pyrroles; Quinolines; Rats; Rats, Inbred Strains; Verapamil | 1992 |
Mechanisms of action of the dilatory response to calcitonin gene-related peptide in guinea pig basilary artery.
Topics: Acetylcholine; Adenylyl Cyclases; Animals; Basilar Artery; Benzopyrans; Calcitonin Gene-Related Peptide; Calcium; Cromakalim; Cyclic AMP; Endothelium, Vascular; Glyburide; Guinea Pigs; In Vitro Techniques; Muscle, Smooth, Vascular; Neurokinin A; Nitric Oxide; Potassium Channels; Pyrroles; Second Messenger Systems; Substance P; Vasodilation; Vasodilator Agents | 1992 |
Comparison of the relaxing effects of cicletanine and cromakalim on vascular smooth muscle.
Topics: Animals; Antihypertensive Agents; Aorta; Benzopyrans; Cromakalim; Diuretics; Dose-Response Relationship, Drug; Glyburide; Guinea Pigs; Iliac Artery; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Portal Vein; Potassium; Pyridines; Pyrroles; Rabbits; Rats; Vasodilation; Vasodilator Agents | 1992 |
Lack of evidence for coupling of the dopamine D2 receptor to an adenosine triphosphate-sensitive potassium (ATP-K+) channel in dopaminergic neurones of the rat substantia nigra.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Dopamine; Electrophysiology; Glyburide; Male; Neurons; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Dopamine D2; Substantia Nigra; Tolbutamide | 1992 |
Hypoglycemia-activated K+ channels in hippocampal neurons.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cells, Cultured; Cromakalim; Glucose; Glyburide; Hippocampus; Hypoglycemia; Ion Channel Gating; Neurons; Potassium Channels; Pyrroles; Rats | 1992 |
Comparison of the in vitro effects of K+ channel modulators on detrusor and portal vein strips from guinea pigs.
Topics: Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Guanidines; Guinea Pigs; In Vitro Techniques; Male; Minoxidil; Muscle, Smooth; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pinacidil; Portal Vein; Potassium Channels; Potassium Chloride; Pyrroles; Vasoconstriction; Vasodilator Agents | 1992 |
Role of ATP-sensitive potassium channels in ovine fetal pulmonary vascular tone.
Topics: Adenosine Triphosphate; Animals; Arginine; Benzopyrans; Cromakalim; Fetus; Glyburide; Nitroarginine; Potassium Channels; Pulmonary Circulation; Pyrroles; Sheep; Vasomotor System | 1992 |
K+ATP-channel activation causes marked vasodilation in the hypertensive neonatal pig lung.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Benzopyrans; Cromakalim; Female; Glyburide; Hypertension, Pulmonary; Male; Potassium Channels; Pulmonary Circulation; Pyrroles; Swine; Vasodilation; Vasodilator Agents; Vasomotor System | 1992 |
[The vasospasmolytic effects of nicorandil, cromakalim and pinacidil on 3,4-diaminopyridine-induced phasic contractions in canine coronary arteries as an experimental vasospasm model].
Topics: 4-Aminopyridine; Amifampridine; Animals; Benzopyrans; Coronary Vasospasm; Cromakalim; Disease Models, Animal; Dogs; Female; Glyburide; Guanidines; In Vitro Techniques; Ion Channel Gating; Male; Methylene Blue; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1992 |
On the pharmacological and physiological role of glibenclamide-sensitive potassium channels in colonic smooth muscle.
Topics: Animals; Benzopyrans; Carbachol; Colforsin; Colon; Cromakalim; Dogs; Drug Interactions; Electric Stimulation; Female; Gallopamil; Glyburide; Male; Muscle Contraction; Muscle, Smooth; Potassium Channels; Pyrroles; Stereoisomerism | 1992 |
Potassium channel modulation in rat portal vein by ATP depletion: a comparison with the effects of levcromakalim (BRL 38227).
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Carboxylic Acids; Cromakalim; Electric Conductivity; Glucose; Glyburide; In Vitro Techniques; Male; Membrane Potentials; Muscle, Smooth, Vascular; Portal Vein; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1992 |
Differential effects of diazoxide, cromakalim and pinacidil on adrenergic neurotransmission and 86Rb+ efflux in rat brain cortical slices.
Topics: Animals; Benzopyrans; Cerebral Cortex; Cocaine; Cromakalim; Diazoxide; Electric Stimulation; Glyburide; Guanidines; Hydrocortisone; In Vitro Techniques; Male; Norepinephrine; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Rubidium Radioisotopes | 1992 |
Calcium-activated potassium channels in native endothelial cells from rabbit aorta: conductance, Ca2+ sensitivity and block.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Aorta; Benzopyrans; Bradykinin; Calcium; Cromakalim; Egtazic Acid; Endothelium, Vascular; Glyburide; Membrane Potentials; Potassium; Potassium Channels; Pyrroles; Quaternary Ammonium Compounds; Rabbits; Vasodilator Agents | 1992 |
External ATP antagonizes the effect of potassium channel openers in guinea-pig ventricular papillary muscle.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Electric Stimulation; Glyburide; Guinea Pigs; Male; Myocardial Contraction; Papillary Muscles; Potassium Channels; Pyridines; Pyrroles; Suramin | 1992 |
Comparative effects of the K+ channel openers, pinacidil and cromakalim on vascular tone: sensitivity to glyburide and calcium.
Topics: Animals; Benzopyrans; Calcium; Cromakalim; Female; Glyburide; Guanidines; Humans; In Vitro Techniques; Isometric Contraction; Muscle Tonus; Muscle, Smooth, Vascular; Pinacidil; Potassium Channels; Pregnancy; Pyrroles; Rats; Rats, Inbred Strains; Ryanodine; Vasodilator Agents | 1992 |
Evidence that epithelium-dependent relaxation of vascular smooth muscle detected by co-axial bioassays is not attributable to hypoxia.
Topics: Animals; Aorta; Benzopyrans; Biological Assay; Biological Factors; Cromakalim; Epithelium; Glyburide; Guinea Pigs; Hypoxia; In Vitro Techniques; Isoproterenol; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Pyrroles; Rats; Rats, Inbred Strains; Respiratory Physiological Phenomena | 1992 |
Effects of BRL 38227 on neurally-mediated responses in the guinea-pig isolated bronchus.
Topics: Albuterol; Animals; Benzopyrans; Bronchi; Bronchoconstriction; Bronchodilator Agents; Cromakalim; Electric Stimulation; Glyburide; Guinea Pigs; In Vitro Techniques; Ketotifen; Male; Neuromuscular Junction; Phentolamine; Potassium Channels; Pyrroles; Salmeterol Xinafoate | 1992 |
The involvement of potassium channels in the action of ciclazindol in rat portal vein.
Topics: Animals; Benzopyrans; Cromakalim; Glyburide; In Vitro Techniques; Indoles; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth, Vascular; Portal Vein; Potassium; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Vasoconstriction; Vasodilator Agents | 1992 |
Comparison of the actions of acetylcholine and BRL 38227 in the guinea-pig coronary artery.
Topics: Acetylcholine; Animals; Benzopyrans; Coronary Vessels; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Channels; Pyridines; Pyrroles; Rabbits; Scorpion Venoms; Vasodilator Agents | 1992 |
Characterization of potassium currents modulated by BRL 38227 in rat portal vein.
Topics: Algorithms; Animals; Benzopyrans; Cromakalim; Electrophysiology; Glyburide; In Vitro Techniques; Male; Membrane Potentials; Portal Vein; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Vasodilator Agents | 1992 |
Hypoxia-evoked dilatation of rabbit isolated basilar arteries is not mediated by the opening of glibenclamide-sensitive potassium channels.
Topics: Animals; Basilar Artery; Benzopyrans; Cromakalim; Glyburide; Hypoxia; In Vitro Techniques; Male; Potassium Channels; Pyrroles; Rabbits; Vasodilation; Vasodilator Agents | 1992 |
Effects of potassium channel blockers on the negative inotropic responses induced by cromakalim and pinacidil in guinea pig atrium.
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Benzopyrans; Cromakalim; Depression, Chemical; Female; Glyburide; Guanidines; Guinea Pigs; Heart Atria; Myocardial Contraction; Pinacidil; Potassium Channels; Pyrroles; Stereoisomerism; Tacrine | 1992 |
Role of endothelium and hyperpolarization in CGRP-induced vasodilation of rabbit ophthalmic artery.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcitonin Gene-Related Peptide; Cromakalim; Electrophysiology; Endothelium, Vascular; Glyburide; Norepinephrine; Ophthalmic Artery; Potassium Channels; Pyrroles; Rabbits; Vasodilation | 1992 |
Effects of cromakalim (BRL 34915) on resting and evoked activity in frog semicircular canals.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Evoked Potentials, Auditory; Glyburide; Hair Cells, Auditory; In Vitro Techniques; Lymph; Parasympatholytics; Physical Stimulation; Potassium; Potassium Channels; Pyrroles; Rana esculenta; Semicircular Canals | 1992 |
A potassium current activated by lemakalim and metabolic inhibition in rabbit mesenteric artery.
Topics: Animals; Benzopyrans; Cromakalim; Dinitrophenols; Electrophysiology; Glyburide; Iodoacetates; Iodoacetic Acid; Male; Mesenteric Arteries; Potassium; Pyrroles; Rabbits | 1992 |
ATP-sensitive K+ channels regulate resting potential of pulmonary arterial smooth muscle cells.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Electrophysiology; Glyburide; In Vitro Techniques; Membrane Potentials; Muscle, Smooth, Vascular; Potassium Channels; Pulmonary Artery; Pyrroles; Rabbits; Vasodilator Agents | 1992 |
Direct action of BRL 38227 and glibenclamide on intracellular calcium stores in cultured airway smooth muscle of rabbit.
Topics: Animals; Benzopyrans; Calcium; Cell Line; Cells, Cultured; Cromakalim; Glyburide; Muscle, Smooth; Pyrroles; Rabbits; Sarcoplasmic Reticulum; Trachea | 1992 |
Differential inhibition by tedisamil (KC 8857) and glibenclamide of the responses to cromakalim and minoxidil sulphate in rat isolated aorta.
Topics: Animals; Aorta; Benzopyrans; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cromakalim; Cyclopropanes; Glyburide; Male; Minoxidil; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Rubidium | 1992 |
Relaxant effects of BRL 38227 and pinacidil on the rat gastric fundus.
Topics: Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Female; Gastric Fundus; Glyburide; Guanidines; In Vitro Techniques; Male; Muscle Relaxation; Phentolamine; Pinacidil; Potassium Channels; Pyrroles; Rats; Vasodilator Agents | 1992 |
Effects of BRL 38227 on potassium currents in smooth muscle cells isolated from rabbit portal vein and human mesenteric artery.
Topics: Animals; Benzopyrans; Cromakalim; Electrophysiology; Female; Glyburide; Humans; In Vitro Techniques; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; Phentolamine; Portal Vein; Potassium Channels; Pyrroles; Rabbits; Vasodilator Agents | 1992 |
Cromakalim and lemakalim activate Ca(2+)-dependent K+ channels in canine colon.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Colon; Cromakalim; Dogs; Glyburide; Ion Channel Gating; Membrane Potentials; Potassium Channels; Pyrroles | 1992 |
The binding site for [3H]glibenclamide in the rat cerebral cortex does not recognize K-channel agonists or antagonists other than sulphonylureas.
Topics: Animals; Benzopyrans; Binding Sites; Calcium Channels; Cerebral Cortex; Cromakalim; Glyburide; Guanidines; In Vitro Techniques; Kinetics; Male; Membranes; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Sulfonylurea Compounds; Vasodilator Agents | 1991 |
Characterization of sulfonylurea receptors and the action of potassium channel openers on cholinergic neurotransmission in guinea pig isolated small intestine.
Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Benzopyrans; Choline; Cromakalim; Electric Stimulation; Glyburide; Guinea Pigs; Intestine, Small; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Picolines; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pyrans; Pyrroles; Receptors, Drug; Sulfonylurea Receptors; Synaptic Transmission; Tritium | 1991 |
Antagonism of relaxin by glibenclamide in the uterus of the rat in vivo.
Topics: Albuterol; Animals; Apamin; Benzopyrans; Cromakalim; Cyclic AMP; Female; Glyburide; Insulin; Ovariectomy; Parasympatholytics; Potassium Channels; Pyrroles; Rats; Relaxin; Uterine Contraction | 1991 |
Vasorelaxant and hypotensive effects of tilisolol hydrochloride (N-696) in isolated rat thoracic aorta and pithed rats.
Topics: Adrenergic beta-Antagonists; Animals; Aorta, Thoracic; Benzopyrans; Blood Pressure; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Hypotension; In Vitro Techniques; Isoquinolines; Male; Pyrroles; Rats; Rats, Inbred Strains; Vasodilator Agents | 1991 |
Selective inhibition of relaxation of guinea-pig trachea by charybdotoxin, a potent Ca(++)-activated K+ channel inhibitor.
Topics: Aminophylline; Animals; Benzopyrans; Calcium; Carbachol; Charybdotoxin; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Guanidines; Guinea Pigs; In Vitro Techniques; Isoproterenol; Male; Muscle Relaxation; Nitroprusside; Pinacidil; Potassium Channels; Pyrroles; Scorpion Venoms; Serotonin; Trachea | 1990 |
Pharmacologic profile of cromakalim in the treatment of myocardial ischemia in isolated rat hearts and anesthetized dogs.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Benzopyrans; Blood Pressure; Cardiovascular Agents; Coronary Circulation; Coronary Disease; Cromakalim; Decanoic Acids; Diltiazem; Dogs; Female; Glyburide; Heart; Heart Rate; Hydroxy Acids; In Vitro Techniques; L-Lactate Dehydrogenase; Male; Myocardial Infarction; Myocardial Reperfusion; Myocardium; Oxygen Consumption; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains | 1990 |
Effects of cromakalim, RP49356, diazoxide, glibenclamide and galanin in rat portal vein.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Diazoxide; Galanin; Glyburide; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Peptides; Picolines; Portal Vein; Potassium Channels; Pyrans; Pyrroles; Rats; Rats, Inbred Strains; Rubidium Radioisotopes; Vasodilator Agents | 1990 |
Glyburide-sensitive K+ channels in cultured rat hippocampal neurons: activation by cromakalim and energy-depleting conditions.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cells, Cultured; Charybdotoxin; Cromakalim; Deoxyglucose; Glyburide; Hippocampus; Neurons; Oligomycins; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Scorpion Venoms | 1991 |
ATP-sensitive K+ channels from aortic smooth muscle incorporated into planar lipid bilayers.
Topics: Adenosine Triphosphate; Animals; Aorta; Benzopyrans; Binding Sites; Charybdotoxin; Cromakalim; Dogs; Glyburide; Lipid Bilayers; Muscle, Smooth, Vascular; Potassium Channels; Pyrroles; Scorpion Venoms; Tetraethylammonium; Tetraethylammonium Compounds; Vasodilator Agents | 1991 |
ATP-sensitive potassium channels do not mediate vasorelaxation by acetylcholine or iloprost.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; Electric Stimulation; Endothelium, Vascular; Glyburide; Iloprost; Male; Mesenteric Arteries; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Vasodilation | 1991 |
Actions of cromakalim in isolated human saphenous vein.
Topics: Antihypertensive Agents; Benzopyrans; Cromakalim; Dinoprost; Glyburide; Humans; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Norepinephrine; Potassium Chloride; Pyrroles; Saphenous Vein; Serotonin; Vasoconstriction | 1992 |
Potent constrictor actions of endothelin-1, endothelin-2, and endothelin-3 in rat isolated portal vein.
Topics: Alkaloids; Animals; Benzopyrans; Calcium; Cromakalim; Endothelins; Glyburide; Indomethacin; Male; Mesenteric Veins; Nicardipine; Phorbols; Portal Vein; Protein Kinase C; Pyrroles; Rats; Rats, Inbred Strains; Staurosporine; Vasoconstriction; Vasodilator Agents | 1992 |
Tedisamil (KC 8857) differentially inhibits the 86Rb+ efflux-stimulating and vasorelaxant properties of cromakalim.
Topics: Animals; Aorta; Benzopyrans; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cardiotonic Agents; Cromakalim; Cyclopropanes; Glyburide; Isometric Contraction; Male; Muscle, Smooth, Vascular; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Rubidium Radioisotopes; Vasodilator Agents | 1991 |
Influence of lemakalim on the pulmonary vascular bed of the cat.
Topics: Animals; Benzopyrans; Blood Gas Analysis; Blood Pressure; Calcitonin; Calcitonin Gene-Related Peptide; Cats; Cromakalim; Female; Glyburide; Hydrogen-Ion Concentration; Male; Perfusion; Pulmonary Circulation; Pyrroles; Vasoactive Intestinal Peptide; Vasodilator Agents | 1991 |
Pulmonary vasodilator responses to RP 52891 are mediated by activation of a glibenclamide-sensitive K+ATP channel.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Adenosine Triphosphate; Animals; Benzopyrans; Blood Gas Analysis; Blood Pressure; Cats; Cromakalim; Female; Glyburide; Guanidines; Hydrogen-Ion Concentration; Isoproterenol; Male; Nitroprusside; Picolines; Pinacidil; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pulmonary Circulation; Pyrans; Pyrroles; Vasodilation; Vasodilator Agents | 1991 |
Inhibition by glibenclamide of the effects of cromakalim on responses of rat vas deferens to naphazoline.
Topics: Animals; Benzopyrans; Cromakalim; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Naphazoline; Parasympatholytics; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Vas Deferens | 1991 |
The effect of potassium channel opening drugs on pulmonary nerves.
Topics: Acetylcholine; Animals; Benzopyrans; Cromakalim; Electric Stimulation; Glyburide; Guinea Pigs; In Vitro Techniques; Lung; Muscle Contraction; Parasympathetic Nervous System; Parasympatholytics; Pyrroles; Trachea | 1991 |
Cromakalim and K+ channels in canine trachealis.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Benzopyrans; Cholinergic Fibers; Cromakalim; Dogs; Electric Stimulation; Female; Glyburide; In Vitro Techniques; Male; Membrane Potentials; Parasympatholytics; Potassium Channels; Pyrroles; Trachea | 1991 |
Comparison of rabbit coronary arterial relaxation induced by acetylcholine and lemakalim: activation of ATP sensitive potassium channels.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Benzopyrans; Coronary Vessels; Cromakalim; Dinoprost; Glyburide; In Vitro Techniques; Potassium Channels; Pyrroles; Rabbits; Vasodilation | 1991 |
NIP-121 and cromakalim, potassium channel openers, preferentially suppress prostanoid-induced contraction of the guinea-pig isolated trachea.
Topics: Animals; Arachidonic Acid; Benzopyrans; Cromakalim; Dinoprost; Glyburide; Guinea Pigs; Indomethacin; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Oxadiazoles; Piperidines; Potassium Channels; Prostaglandin D2; Prostaglandin Endoperoxides, Synthetic; Prostaglandins; Pyrroles; Sulfonamides; Trachea | 1991 |
Analysis of pulmonary and systemic vascular responses to cromakalim, an activator of K+ATP channels.
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Benzopyrans; Blood Circulation; Cats; Cromakalim; Endothelins; Glyburide; Guanidines; Heart Rate; Hindlimb; Myocardial Contraction; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pulmonary Circulation; Pyrroles; Vascular Resistance; Vasodilator Agents; Ventricular Function, Right | 1991 |
The dualistic mode of action of the vasodilator drug, nicorandil, differentiated by glibenclamide in 86Rb flux studies in rabbit isolated vascular smooth muscle.
Topics: Animals; Aorta; Benzopyrans; Cromakalim; Glyburide; Membranes; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Norepinephrine; Potassium; Potassium Channels; Pyrroles; Rabbits; Rubidium Radioisotopes; Stimulation, Chemical; Vasodilator Agents | 1991 |
Differential antagonism by glibenclamide of the relaxant effects of cromakalim, pinacidil and nicorandil on canine large coronary arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arteries; Benzopyrans; Coronary Vessels; Cromakalim; Dogs; Dose-Response Relationship, Drug; Female; Glyburide; Guanidines; Male; Methylene Blue; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Pinacidil; Potassium; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Vasodilator Agents | 1991 |
Analysis of cromakalim-, pinacidil-, and nicorandil-induced relaxation of the 5-hydroxytryptamine precontracted rat isolated basilar artery.
Topics: Animals; Basilar Artery; Benzopyrans; Cromakalim; Drug Interactions; Glyburide; Guanidines; Male; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Vasoconstriction; Vasodilation; Vasodilator Agents | 1991 |
Potassium channel opening properties of a novel compound, NIP-121, cromakalim and nicorandil in rat aorta and portal vein.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Benzopyrans; Cromakalim; Glyburide; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Oxadiazoles; Phentolamine; Piperidines; Portal Vein; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Inbred Strains; Rubidium Radioisotopes | 1991 |
Activation by cromakalim of pre- and post-synaptic ATP-sensitive K+ channels in substantia nigra.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Bicuculline; Cromakalim; Glyburide; In Vitro Techniques; Kinetics; Male; Membrane Potentials; Parasympatholytics; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Substantia Nigra; Synapses | 1991 |
RP 49356 and cromakalim relax airway smooth muscle in vitro by opening a sulphonylurea-sensitive K+ channel: a comparison with nifedipine.
Topics: Animals; Benzopyrans; Calcium; Cromakalim; Glipizide; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Nifedipine; Picolines; Potassium Channels; Pyrans; Pyrroles; Trachea | 1991 |
Stimulation of arterial 42K efflux by ATP depletion and cromakalim is antagonized by glyburide.
Topics: Adenosine Triphosphate; Animals; Arteries; Benzopyrans; Cromakalim; Glyburide; Male; Potassium; Potassium Radioisotopes; Pyrroles; Rabbits; Vasodilator Agents | 1991 |
Block of calcium-activated potassium channels in mammalian arterial myocytes by tetraethylammonium ions.
Topics: Adenosine Triphosphate; Animals; Arteries; Benzopyrans; Calcium; Cromakalim; Electrophysiology; Glyburide; Ions; Kinetics; Potassium; Potassium Channels; Pyrroles; Quaternary Ammonium Compounds; Tetraethylammonium; Tetraethylammonium Compounds | 1991 |
Potassium channel activation by cromakalim affects the slow wave type action potential of colonic smooth muscle.
Topics: Action Potentials; Animals; Benzopyrans; Colon; Cromakalim; Dogs; Female; Glyburide; In Vitro Techniques; Male; Muscle, Smooth; Potassium Channels; Pyrroles; Tetraethylammonium Compounds | 1991 |
Effects of glibenclamide on cytosolic calcium concentrations and on contraction of the rabbit aorta.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Calcium; Cromakalim; Cytosol; Fura-2; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Potassium; Pyrroles; Rabbits | 1991 |
Effects of the K+ channel activators, RP 52891, cromakalim and diazoxide, on the plasma insulin level, plasma renin activity and blood pressure in rats.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Blood Glucose; Blood Pressure; Cromakalim; Diazoxide; Drug Interactions; Glucose; Glyburide; Infusions, Intravenous; Insulin; Male; Membrane Potentials; Picolines; Potassium Channels; Pyrans; Pyrroles; Rats; Renin | 1991 |
Comparison of cromakalim-induced relaxation of potassium precontracted rabbit, cat, and rat isolated cerebral arteries.
Topics: Animals; Benzopyrans; Cats; Cerebral Arteries; Cromakalim; Glyburide; Male; Muscle, Smooth, Vascular; Potassium Channels; Potassium Chloride; Pyrroles; Rabbits; Rats; Rats, Inbred Strains; Species Specificity; Vasodilation; Vasodilator Agents | 1991 |
LTD4 and bradykinin evoke endothelium-dependent relaxation of the renal vein: dissimilar mechanisms.
Topics: Animals; Arginine; Benzopyrans; Bradykinin; Chromones; Cromakalim; Dogs; Endothelium, Vascular; Glyburide; Hemoglobins; Male; Methylene Blue; omega-N-Methylarginine; Pyrroles; Renal Veins; SRS-A; Vasodilation; Vasodilator Agents; Vasomotor System | 1991 |
Antihypertensive and haemodynamic properties of the potassium channel activating (-) enantiomer of cromakalim in animal models.
Topics: Anesthesia; Animals; Antihypertensive Agents; Benzopyrans; Cats; Cromakalim; Dogs; Female; Glyburide; Heart; Heart Rate; Hemodynamics; Hypertension, Renal; Male; Potassium Channels; Pyrroles; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Renal Circulation; Stereoisomerism | 1991 |
ATP-dependent K+ channels modulate vasoconstrictor responses to severe hypoxia in isolated ferret lungs.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Ferrets; Glucose; Glyburide; Hypoxia; In Vitro Techniques; Lung; Male; Oxygen; Potassium Channels; Pyrroles; Vasoconstriction; Vasodilator Agents | 1991 |
Cromakalim and pinacidil dilate small mesenteric arteries but not small cerebral arteries.
Topics: Animals; Benzopyrans; Cerebral Arteries; Cromakalim; Glyburide; Guanidines; Male; Mesenteric Arteries; Pinacidil; Potassium; Potassium Channels; Pyrroles; Rats; Rats, Inbred WKY; Vasodilation; Vasodilator Agents | 1991 |
Evidence that acetylcholine-mediated hyperpolarization of the rat small mesenteric artery does not involve the K+ channel opened by cromakalim.
Topics: Acetylcholine; Animals; Benzopyrans; Cromakalim; Electrophysiology; Glyburide; In Vitro Techniques; Membrane Potentials; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Phentolamine; Potassium Channels; Pyrroles; Rats; Rats, Inbred WKY; Swine; Vasodilator Agents | 1991 |
Two different types of channels are targets for potassium channel openers in Xenopus oocytes.
Topics: Animals; Benzopyrans; Cromakalim; Electric Conductivity; Female; Glyburide; Guanidines; Oocytes; Organic Chemicals; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents; Xenopus laevis | 1991 |
Effect of potassium channel blockade on the anti-ischemic actions of mechanistically diverse agents.
Topics: Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Benzopyrans; Coronary Circulation; Coronary Disease; Cromakalim; Glyburide; Lidocaine; Male; Piperidines; Potassium Channels; Pyridines; Pyrroles; Rats; Rats, Inbred Strains | 1991 |
Specific block of the anti-ischemic actions of cromakalim by sodium 5-hydroxydecanoate.
Topics: Animals; Benzopyrans; Coronary Disease; Cromakalim; Decanoic Acids; Electrophysiology; Glyburide; Heart; Humans; Hydroxy Acids; In Vitro Techniques; Infant, Newborn; Male; Muscle, Smooth, Vascular; Pyrroles; Rats; Rats, Inbred Strains; Vasodilator Agents | 1991 |
Hyperpolarization of denervated skeletal muscle by lemakalim and its antagonism by glybenclamide and tolbutamide.
Topics: Animals; Benzopyrans; Calcium Channel Blockers; Cesium; Cromakalim; Female; Glyburide; Male; Membrane Potentials; Mice; Muscle Denervation; Muscles; Pyrroles; Tolbutamide | 1991 |
Effect of depolarizing and hyperpolarizing agents on the membrane potential difference of primary cultures of rabbit aorta vascular smooth muscle cells.
Topics: Animals; Aorta; Benzopyrans; Cattle; Cells, Cultured; Colforsin; Cromakalim; Glyburide; Membrane Potentials; Muscle, Smooth, Vascular; Nucleotides; Pyrroles; Rabbits | 1991 |
Some degree of overlap exists between the K(+)-channels opened by cromakalim and those opened by minoxidil sulphate in rat isolated aorta.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; Glyburide; In Vitro Techniques; Male; Minoxidil; Muscle Contraction; Muscle, Smooth, Vascular; Potassium; Potassium Channels; Potassium Radioisotopes; Pyrroles; Rats; Rats, Inbred Strains; Rubidium; Rubidium Radioisotopes; Vasodilator Agents | 1991 |
Hypoxic dilation of coronary arteries is mediated by ATP-sensitive potassium channels.
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Benzopyrans; Bradykinin; Coronary Vessels; Cromakalim; Endothelium, Vascular; Glyburide; Guinea Pigs; Hypoxia; In Vitro Techniques; Ischemia; Potassium Channels; Pyrroles; Vasodilation | 1990 |
A potassium channel activator modulates both excitatory noncholinergic and cholinergic neurotransmission in guinea pig airways.
Topics: Animals; Benzopyrans; Bronchi; Capsaicin; Cromakalim; Drug Interactions; Glyburide; Guinea Pigs; Hemodynamics; Male; Neural Conduction; Parasympatholytics; Phentolamine; Potassium Channels; Pyrroles; Vagus Nerve | 1990 |
Effects of BRL 34915 (cromakalim) on renal hemodynamics and function in anesthetized dogs.
Topics: Animals; Benzopyrans; Cromakalim; Dogs; Female; Glomerular Filtration Rate; Glyburide; Hemodynamics; Injections, Intravenous; Kidney; Male; Parasympatholytics; Pentobarbital; Pyrroles; Renal Circulation | 1990 |
Alterations by glyburide of effects of BRL 34915 and P 1060 on contraction, 86Rb efflux and the maxi-K+ channel in rat portal vein.
Topics: Animals; Benzopyrans; Cromakalim; Glyburide; Guanidines; In Vitro Techniques; Male; Membrane Potentials; Muscle, Smooth, Vascular; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Rubidium Radioisotopes; Vasoconstriction; Vasodilator Agents | 1990 |
Glibenclamide blocks the relaxant action of pinacidil and cromakalim in airway smooth muscle.
Topics: Animals; Benzopyrans; Cromakalim; Female; Glyburide; Guanidines; Guinea Pigs; Histamine; In Vitro Techniques; Male; Muscle Relaxants, Central; Muscle Relaxation; Muscle, Smooth; Pinacidil; Pyrroles; Terbutaline; Theophylline; Trachea; Verapamil | 1990 |
Evidence that pinacidil may promote the opening of ATP-sensitive K+ channels yet inhibit the opening of Ca2(+)-activated K+ channels in K(+)-contracted canine mesenteric artery.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Cromakalim; Dogs; Female; Glyburide; Guanidines; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Pinacidil; Potassium; Potassium Channels; Pyrroles; Rubidium Radioisotopes | 1990 |
Characterization of responses to cromakalim and pinacidil in smooth and cardiac muscle by use of selective antagonists.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Clonidine; Coronary Vessels; Cromakalim; Dogs; Electric Stimulation; Glyburide; Guanidines; Guinea Pigs; Heart; In Vitro Techniques; Isoproterenol; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Myocardial Contraction; Phentolamine; Pinacidil; Potassium Channels; Pyrroles; Rats | 1990 |
Contrasting effects of hypoxia on tension in rat pulmonary and mesenteric arteries.
Topics: Animals; Benzopyrans; Cromakalim; Endothelium, Vascular; Glyburide; Hypoxia; In Vitro Techniques; Male; Mesenteric Arteries; Potassium; Pulmonary Artery; Pyrroles; Rats; Rats, Inbred Strains; Rest; Vasoconstriction; Vasodilator Agents; Verapamil | 1990 |
Action of cromakalim on potassium membrane conductance in isolated heart myocytes of frog.
Topics: Adenosine Triphosphate; Animals; Barium; Benzopyrans; Cesium; Cromakalim; Glyburide; In Vitro Techniques; Membranes; Myocardium; Potassium Channels; Pyrroles; Rana esculenta; Sulfonylurea Compounds; Tolbutamide | 1990 |
Functional changes in potassium channels in carotid arteries from stroke-prone spontaneously hypertensive rats.
Topics: Animals; Benzopyrans; Carotid Arteries; Cerebrovascular Disorders; Cromakalim; Glyburide; Hypertension; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Norepinephrine; Potassium Channels; Pyrroles; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1990 |
Hypoglycemic sulfonylureas antagonize the effects of cromakalim and pinacidil on 86Rb fluxes and contractile activity in the rat aorta.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; Glyburide; Guanidines; Hypoglycemic Agents; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroprusside; Parasympatholytics; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Rubidium Radioisotopes; Sulfonylurea Compounds; Tetraethylammonium Compounds; Tolbutamide; Vasodilator Agents | 1990 |
Possible involvement of ATP-sensitive K+ channels in the relaxant response of dog middle cerebral artery to cromakalim.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Cerebral Arteries; Cromakalim; Dogs; Female; Glyburide; In Vitro Techniques; Male; Permeability; Potassium; Potassium Channels; Pyrroles; Rubidium Radioisotopes; Vasodilation; Vasodilator Agents | 1990 |
The action of a potassium channel activator, BRL 38227 (lemakalim), on human airway smooth muscle.
Topics: Benzopyrans; Bronchi; Bronchoconstriction; Bronchodilator Agents; Cromakalim; Electric Stimulation; Glyburide; Humans; In Vitro Techniques; Muscle, Smooth; Potassium Channels; Pyrroles | 1990 |
A comparison of the actions of cromakalim and nifedipine on rabbit isolated mesenteric artery.
Topics: Animals; Benzopyrans; Blood Pressure; Cell Membrane; Cromakalim; Electric Stimulation; Glyburide; Humans; In Vitro Techniques; Infant, Newborn; Male; Membrane Potentials; Mesenteric Arteries; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Perfusion; Potassium Channels; Pyrroles; Rabbits | 1990 |
Paradoxical inhibitory effect of cromakalim on 86Rb outflow from pancreatic islet cells.
Topics: Animals; Benzopyrans; Calcium; Calcium Radioisotopes; Cromakalim; Extracellular Space; Glucose; Glyburide; Insulin; Insulin Secretion; Islets of Langerhans; Parasympatholytics; Perfusion; Potassium Chloride; Pyrroles; Rats; Rubidium; Rubidium Radioisotopes | 1990 |
Two different types of potassium channels in human skeletal muscle activated by potassium channel openers.
Topics: Adenosine Triphosphate; Benzopyrans; Cromakalim; Dihydropyridines; Electrophysiology; Glyburide; Humans; Muscles; Picolines; Potassium Channels; Pyrans; Pyrroles | 1990 |
Effects of several potassium channel openers and glibenclamide on the uterus of the rat.
Topics: Animals; Benzopyrans; Blood Pressure; Cromakalim; Female; Glyburide; Guanidines; Heart Rate; Hemodynamics; In Vitro Techniques; Oxytocin; Parasympatholytics; Picolines; Pinacidil; Potassium Channels; Potassium Chloride; Pregnancy; Pyrans; Pyrroles; Rats; Rats, Inbred Strains; Uterus; Vasodilator Agents | 1990 |
Specific but differential antagonism by glibenclamide of the vasodepressor effects of cromakalim and nicorandil in spinally-anaesthetized dogs.
Topics: Anesthesia, Spinal; Animals; Benzopyrans; Blood Pressure; Calcium Channel Blockers; Cromakalim; Diltiazem; Dogs; Dose-Response Relationship, Drug; Female; Glyburide; Heart Rate; Hemodynamics; Male; Myocardial Contraction; Niacinamide; Nicorandil; Nitroglycerin; Norepinephrine; Potassium Channels; Pyrroles | 1990 |
Cytoplasmic calcium and the relaxation of canine coronary arterial smooth muscle produced by cromakalim, pinacidil and nicorandil.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Coronary Vessels; Cromakalim; Cytoplasm; Dogs; Female; Fluorescence; Glyburide; Guanidines; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pinacidil; Potassium Chloride; Pyrroles; Quaternary Ammonium Compounds | 1990 |
Specific antagonism by glibenclamide of negative inotropic effects of potassium channel openers in canine atrial muscle.
Topics: Animals; Benzopyrans; Carbachol; Cromakalim; Dogs; Female; Glyburide; Guanidines; Heart Atria; Male; Myocardial Contraction; Niacinamide; Nicorandil; Nifedipine; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1990 |
Nicorandil increases coronary blood flow predominantly by K-channel opening mechanism.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Coronary Circulation; Cromakalim; Dogs; Dose-Response Relationship, Drug; Female; Glyburide; In Vitro Techniques; Male; Myocardial Contraction; Niacinamide; Nicorandil; Nitroglycerin; Potassium Channels; Pyrroles; Vasodilator Agents | 1990 |
Comparison of effects of cromakalim and pinacidil on mechanical activity and 86Rb efflux in dog coronary arteries.
Topics: Animals; Benzopyrans; Calcium Channels; Coronary Vessels; Cromakalim; Dogs; Female; Glyburide; Guanidines; Male; Muscle, Smooth, Vascular; Pinacidil; Potassium Channels; Pyrroles; Rubidium Radioisotopes; Vasoconstriction; Vasodilator Agents | 1990 |
The action of diazoxide and minoxidil sulphate on rat blood vessels: a comparison with cromakalim.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Benzopyrans; Cromakalim; Cyclic AMP; Cyclic GMP; Diazoxide; Glyburide; In Vitro Techniques; Male; Membrane Potentials; Microelectrodes; Minoxidil; Muscle, Smooth, Vascular; Portal Vein; Potassium Channels; Potassium Radioisotopes; Pyrroles; Rabbits; Rats; Rats, Inbred Strains; Rubidium Radioisotopes | 1990 |
Mechanisms of inhibitory effects of CD-349 and K(+)-channel activators on noradrenaline-induced contraction and changes in levels of cyclic GMP in rat aorta.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Calcium Channel Agonists; Calcium Channel Blockers; Cromakalim; Cyclic GMP; Dihydropyridines; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains | 1990 |
The potassium channel opener cromakalim (BRL 34915) activates ATP-dependent K+ channels in isolated cardiac myocytes.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Glyburide; Guinea Pigs; Ion Channels; Myocardium; Potassium; Pyrroles | 1988 |
BRL 34915 (cromakalim) activates ATP-sensitive K+ current in cardiac muscle.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Antihypertensive Agents; Benzopyrans; Cromakalim; Electrophysiology; Ferrets; Glyburide; Guinea Pigs; Heart; Hypoxia; Ion Channels; Myocardium; Potassium; Pyrroles | 1988 |
Glyburide blocks the relaxation response to BRL 34915 (cromakalim), minoxidil sulfate and diazoxide in vascular smooth muscle.
Topics: 4-Aminopyridine; Adenosine Triphosphate; Aminopyridines; Animals; Antihypertensive Agents; Benzopyrans; Charybdotoxin; Cromakalim; Diazoxide; Glyburide; Male; Minoxidil; Muscle, Smooth, Vascular; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Scorpion Venoms; Tetraethylammonium; Tetraethylammonium Compounds; Vasodilation | 1989 |
Competitive antagonism by glibenclamide of cromakalim inhibition of twitch contractions in rabbit vas deferens.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Benzopyrans; Calcium Channel Blockers; Cromakalim; Electric Stimulation; Glyburide; In Vitro Techniques; Male; Muscle, Smooth; Potassium Channels; Pyrroles; Rabbits; Vas Deferens | 1989 |
Vasorelaxant effects of cromakalim in rats are mediated by glibenclamide-sensitive potassium channels.
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Benzopyrans; Blood Pressure; Cromakalim; Glyburide; Hemodynamics; In Vitro Techniques; Male; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Inbred SHR; Vasodilation | 1989 |
Inhibition by glibenclamide of the vasorelaxant action of cromakalim in the rat.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Blood Pressure; Cromakalim; Glyburide; Heart Rate; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Parasympatholytics; Portal Vein; Pyrroles; Rats; Rats, Inbred Strains; Rubidium Radioisotopes | 1989 |
Inhibition by sulphonylureas of vasorelaxation induced by K+ channel activators in vitro.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Cromakalim; Drug Interactions; Glipizide; Glyburide; Guanidines; In Vitro Techniques; Male; Nifedipine; Norepinephrine; Pinacidil; Potassium Channels; Potassium Chloride; Pyrroles; Rabbits; Sulfonylurea Compounds; Tolbutamide; Vasodilator Agents | 1989 |
In vitro and in vivo comparison of two K+ channel openers, diazoxide and cromakalim, and their inhibition by glibenclamide.
Topics: Angiotensin II; Animals; Aorta; Benzopyrans; Blood Pressure; Cromakalim; Diazoxide; Glyburide; Heart Rate; In Vitro Techniques; Muscle, Smooth, Vascular; Norepinephrine; Portal Vein; Potassium Channels; Pyrroles; Rabbits; Rats; Rats, Inbred SHR; Rubidium; Vasoconstriction | 1989 |
Hyperpolarizing vasodilators activate ATP-sensitive K+ channels in arterial smooth muscle.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Benzopyrans; Cerebral Arteries; Cromakalim; Diazoxide; Glyburide; Guanidines; Mesenteric Arteries; Muscle, Smooth, Vascular; Pinacidil; Potassium Channels; Pyrroles; Rabbits; Rats; Tolbutamide; Vasoactive Intestinal Peptide; Vasodilator Agents | 1989 |
Influence of ATP-sensitive potassium channel modulators on ischemia-induced fibrillation in isolated rat hearts.
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Arrhythmias, Cardiac; Benzopyrans; Coronary Circulation; Coronary Disease; Cromakalim; Glyburide; Guanidines; Heart; Heart Rate; In Vitro Techniques; Male; Perfusion; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Tolbutamide; Vascular Resistance | 1989 |
A comparison of the effects and interactions of cromakalim and glibenclamide in cardiac and vascular tissues.
Topics: Animals; Aorta; Benzopyrans; Cromakalim; Electrophysiology; Glyburide; Guinea Pigs; In Vitro Techniques; Muscle, Smooth, Vascular; Papillary Muscles; Portal Vein; Potassium Channels; Pyrroles; Rats; Vasodilator Agents | 1989 |
Anti-ischemic effects of the potassium channel activators pinacidil and cromakalim and the reversal of these effects with the potassium channel blocker glyburide.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Coronary Disease; Cromakalim; Glyburide; Guanidines; In Vitro Techniques; Male; Membrane Potentials; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains | 1989 |
Potassium channel openers act through an activation of ATP-sensitive K+ channels in guinea-pig cardiac myocytes.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Electrophysiology; Glyburide; Guanidines; Guinea Pigs; Heart; In Vitro Techniques; Ion Channel Gating; Muscle, Smooth, Vascular; Picolines; Pinacidil; Potassium Channels; Pyrans; Pyrroles; Subtraction Technique | 1989 |
Cromakalim-induced relaxation of guinea-pig isolated trachealis: antagonism by glibenclamide and by phentolamine.
Topics: Animals; Benzopyrans; Cromakalim; Electrophysiology; Female; Glyburide; Guinea Pigs; In Vitro Techniques; Isometric Contraction; Male; Muscle Relaxation; Muscle, Smooth; Parasympatholytics; Phentolamine; Potassium Channels; Pyrroles; Trachea | 1989 |
Effects of cromakalim and glibenclamide on isolated strips of bovine tracheal smooth muscle. Smooth Muscle Research Group.
Topics: Animals; Benzopyrans; Cattle; Cromakalim; Glyburide; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Pyrroles; Rubidium Radioisotopes; Trachea | 1989 |
Effects of glibenclamide on cromakalim-induced responses in rabbit isolated aorta.
Topics: Animals; Aorta; Benzopyrans; Cromakalim; Drug Interactions; Glyburide; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Parasympatholytics; Pyrroles; Rabbits | 1989 |
Cromakalim, RP49356, pinacidil and minoxidil sulphate in the rat uterus and their antagonism by glibenclamide. Smooth Muscle Research Group.
Topics: Animals; Benzopyrans; Cromakalim; Female; Glyburide; Guanidines; In Vitro Techniques; Minoxidil; Parasympatholytics; Picolines; Pinacidil; Pyrans; Pyrroles; Rats; Rats, Inbred Strains; Uterine Contraction | 1989 |
Effect of cromakalim on smooth muscle cells of guinea-pig taenia caeci.
Topics: Animals; Benzopyrans; Cecum; Cromakalim; Electrophysiology; Female; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Pyrroles | 1989 |
Glibenclamide is a competitive antagonist of cromakalim, pinacidil and RP 49356 in guinea-pig pulmonary artery.
Topics: Animals; Benzopyrans; Cromakalim; Glyburide; Guanidines; Guinea Pigs; In Vitro Techniques; Male; Methylene Blue; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Picolines; Pinacidil; Potassium Channels; Potassium Chloride; Pulmonary Artery; Purinones; Pyrans; Pyrroles; Tetraethylammonium Compounds | 1989 |
KR-30450, a newly synthesized benzopyran derivative, activates the cardiac ATP-sensitive K+ channel.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cells, Cultured; Cromakalim; Glyburide; Guanidines; Heart; Phenylbutyrates; Potassium Channels; Pyrroles; Pyrrolidinones; Rats | 1995 |
Effects of cromakalim or glibenclamide on arrhythmias and dispersion of refractoriness in chronically infarcted in anesthetized dogs.
Topics: Adenosine Triphosphate; Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzopyrans; Blood Pressure; Cromakalim; Dogs; Electric Stimulation; Electrophysiology; Female; Glyburide; Heart Rate; In Vitro Techniques; Male; Myocardial Infarction; Potassium Channels; Pyrroles; Refractory Period, Electrophysiological; Ventricular Fibrillation; Ventricular Function | 1995 |
Potassium channel inhibitors attenuate neuromodulatory effects of atrial natriuretic factor in the rabbit isolated vas deferens.
Topics: 4-Aminopyridine; Adenosine Triphosphate; Animals; Atrial Natriuretic Factor; Benzopyrans; Charybdotoxin; Cromakalim; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Norepinephrine; Potassium Channel Blockers; Potassium Channels; Prazosin; Pyrroles; Rabbits; Receptors, Adrenergic; Scorpion Venoms; Synaptic Transmission; Tetraethylammonium; Tetraethylammonium Compounds; Vas Deferens | 1994 |
Pharmacological evidence that calcitonin gene-related peptide is implicated in cerebral autoregulation.
Topics: Animals; Benzopyrans; Calcitonin Gene-Related Peptide; Capsaicin; Cerebrovascular Circulation; Cromakalim; Glyburide; Homeostasis; Neuropeptides; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide; Substance P; Vasodilator Agents | 1994 |
Effects of ATP-sensitive K+ channel openers on pacemaker activity in isolated single rabbit sino-atrial node cells.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Electrophysiology; Glyburide; Guanidines; Heart Rate; In Vitro Techniques; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Rabbits; Sinoatrial Node; Vasodilator Agents | 1993 |
Action of KC-399, a newly synthesized potassium channel opener, on mechanical activity and 86Rb efflux in rat aorta.
Topics: Adenosine Triphosphate; Animals; Aorta, Thoracic; Benzopyrans; Charybdotoxin; Cromakalim; Glyburide; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Norepinephrine; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Rubidium Radioisotopes; Scorpion Venoms; Vasodilation | 1994 |
Glibenclamide-induced oscillation of canine coronary artery is independent of myocardial ischemia.
Topics: Adenosine Triphosphate; Animals; Arginine; Benzopyrans; Coronary Circulation; Coronary Vessels; Cromakalim; Diltiazem; Dogs; Female; Glyburide; In Vitro Techniques; Male; Muscle Tonus; Muscle, Smooth, Vascular; Myocardial Ischemia; Niacinamide; Nicorandil; Nitroarginine; Nitroglycerin; Potassium Channels; Pyrroles; Vasodilator Agents | 1994 |
Evidence that prostaglandins I2, E2, and D2 may activate ATP sensitive potassium channels in the isolated rat heart.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Benzopyrans; Cromakalim; Dinoprostone; Dose-Response Relationship, Drug; Glyburide; Iloprost; In Vitro Techniques; Ion Channel Gating; Male; Myocardium; Perfusion; Potassium Channels; Pressure; Prostaglandin D2; Prostaglandins; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1994 |
Vasodilating actions of cromakalim in resting and contracting states of carotid arteries from spontaneously hypertensive rats.
Topics: Animals; Benzopyrans; Carotid Arteries; Charybdotoxin; Cromakalim; Drug Interactions; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Potassium; Pyrroles; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Scorpion Venoms; Species Specificity; Vasodilator Agents | 1994 |
Functional evidence for a glibenclamide-sensitive K+ channel in rat ileal smooth muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Benzopyrans; Calcitonin Gene-Related Peptide; Carbachol; Cromakalim; Glyburide; Ileum; Male; Muscle Contraction; Muscle, Smooth; Potassium Channels; Pyrroles; Rats; Rats, Wistar | 1994 |
Propagation of impulses in the guinea-pig ureter and its blockade by calcitonin gene-related peptide (CGRP).
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Animals; Benzopyrans; Calcitonin Gene-Related Peptide; Cromakalim; Electric Stimulation; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Pyrroles; Tetrodotoxin; Ureter | 1995 |
ATP-sensitive K+ channels mediate regulation of substance P release via the prejunctional histamine H3 receptor.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Benzopyrans; Cromakalim; Glyburide; Hindlimb; Histamine Agonists; Injections, Intravenous; Male; Methylhistamines; Neuromuscular Junction; Potassium Channel Blockers; Potassium Channels; Pyrroles; Radioimmunoassay; Rats; Rats, Wistar; Receptors, Histamine H3; Skin; Stereoisomerism; Substance P; Tetraethylammonium; Tetraethylammonium Compounds; Vasodilator Agents | 1995 |
Calcitonin gene-related peptide mediated neurogenic vasorelaxation in the isolated canine lingual artery.
Topics: Animals; Arginine; Benzopyrans; Calcitonin Gene-Related Peptide; Capsaicin; Cromakalim; Dogs; Electric Stimulation; Female; Glyburide; Humans; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Norepinephrine; omega-N-Methylarginine; Peptide Fragments; Potassium Channel Blockers; Potassium Channels; Propranolol; Pyrroles; Substance P; Tetraethylammonium; Tetraethylammonium Compounds; Tetrodotoxin; Vasoconstriction; Vasodilator Agents | 1995 |
Pharmacological evidence for the persistent activation of ATP-sensitive K+ channels in early phase of reperfusion and its protective role against myocardial stunning.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Benzopyrans; Cromakalim; Glyburide; Guinea Pigs; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion; Myocardial Reperfusion Injury; Myocardial Stunning; Myocardium; Perfusion; Potassium Channels; Pyrroles | 1995 |
Effect of L-NMMA, cromakalim, and glibenclamide on cerebral blood flow in hypercapnia and hypoxia.
Topics: Animals; Arginine; Arteries; Benzopyrans; Cerebrovascular Circulation; Cromakalim; Glyburide; Hypercapnia; Hypoxia; Nitric Oxide Synthase; omega-N-Methylarginine; Pyrroles; Rats; Theophylline; Vasodilator Agents | 1995 |
The effects of glibenclamide on tetanic force and intracellular calcium in normal and fatigued mouse skeletal muscle.
Topics: Acidosis; Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Cromakalim; Electric Stimulation; Glyburide; Intracellular Membranes; Male; Mice; Muscle Contraction; Muscle Fatigue; Muscle, Skeletal; Potassium Channel Blockers; Potassium Channels; Pyrroles; Reference Values | 1995 |
Regulation of glibenclamide-sensitive K+ current by nucleotide phosphates in isolated rabbit pulmonary myocytes.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Biological Transport, Active; Cells, Cultured; Cromakalim; Glyburide; Guanosine Diphosphate; Male; Patch-Clamp Techniques; Potassium Channels; Pulmonary Artery; Pyrroles; Rabbits; Vasodilator Agents | 1995 |
ATP-sensitive K+ channels are not involved in ischemia-reperfusion lung endothelial injury.
Topics: Adenosine; Adenosine Triphosphate; Animals; Benzopyrans; Capillary Permeability; Cromakalim; Endothelium; Glyburide; Hemodynamics; Hypoglycemic Agents; In Vitro Techniques; Ischemia; Lung; Male; Potassium Channels; Pulmonary Circulation; Pulmonary Wedge Pressure; Pyrroles; Rats; Reperfusion Injury; Vascular Resistance; Vasodilator Agents | 1995 |
Effects of levcromakalim and glibenclamide on paced guinea-pig atrial strips exposed to hypoxia.
Topics: Animals; Benzopyrans; Cardiac Pacing, Artificial; Cromakalim; Deoxyglucose; Dose-Response Relationship, Drug; Female; Glyburide; Glycolysis; Guinea Pigs; Heart Atria; Hypoxia; In Vitro Techniques; Male; Myocardial Contraction; Parasympatholytics; Potassium Channels; Pyrroles | 1995 |
ZENECA ZD6169: a novel KATP channel opener with in vivo selectivity for urinary bladder.
Topics: Adenosine Triphosphate; Amides; Animals; Benzophenones; Benzopyrans; Blood Pressure; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Heart Rate; Male; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Urinary Bladder | 1995 |
Activation of ATP-dependent K+ channels by metabolic poisoning in adult mouse skeletal muscle: role of intracellular Mg(2+) and pH.
Topics: 2,4-Dinitrophenol; Adenosine Triphosphate; Animals; Antimetabolites; Benzopyrans; Cell Adhesion; Cromakalim; Cyanides; Dinitrofluorobenzene; Dinitrophenols; Electrophysiology; Glyburide; Hydrogen-Ion Concentration; In Vitro Techniques; Magnesium; Mice; Muscle Fibers, Skeletal; Muscle, Skeletal; Patch-Clamp Techniques; Potassium Channels; Pyrroles; Uncoupling Agents | 1995 |
Potassium channel blockade of atrial negative inotropic responses to P1-purinoceptor and muscarinic receptor agonists and to cromakalim.
Topics: 4-Aminopyridine; Adenosine; Animals; Benzopyrans; Carbachol; Cromakalim; Depression, Chemical; Glyburide; Guinea Pigs; Heart Atria; Hydrochloric Acid; In Vitro Techniques; Male; Myocardial Contraction; Parasympatholytics; Phenylisopropyladenosine; Potassium Channels; Pyrroles; Receptors, Muscarinic; Receptors, Purinergic; Rubidium Radioisotopes | 1993 |
Cromakalim inhibits multiple mechanisms of smooth muscle activation with similar stereoselectivity.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Calcium; Cromakalim; Glyburide; In Vitro Techniques; Muscle Contraction; Muscle Tonus; Muscle, Smooth, Vascular; Neuromuscular Depolarizing Agents; Norepinephrine; Potassium Chloride; Pyrroles; Rabbits; Stereoisomerism; Vasodilator Agents | 1993 |
Effect of KRN2391 on venous return: comparison with other vasodilators.
Topics: Animals; Benzopyrans; Cromakalim; Dogs; Female; Glyburide; Hemodynamics; Male; Niacinamide; Nicorandil; Nifedipine; Nitroglycerin; Potassium Channels; Pyridines; Pyrroles; Vasodilator Agents; Veins | 1993 |
A simple method for measurement of ureteric peristaltic function in vivo and the effects of drugs acting on ion channels applied from the ureter lumen in anesthetized rats.
Topics: 4-Aminopyridine; Anesthesia; Animals; Benzopyrans; Cromakalim; Glyburide; Ion Channels; Lidocaine; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Pyrroles; Rats; Rats, Sprague-Dawley; Ureter; Vasodilator Agents | 1993 |
Cardiovascular effects of YM099, a novel K+ channel opener, in anesthetized and conscious dogs.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Blood Flow Velocity; Blood Pressure; Cardiac Output; Cardiovascular System; Carotid Arteries; Coronary Circulation; Cromakalim; Cyclic N-Oxides; Dipyridamole; Dogs; Dose-Response Relationship, Drug; Female; Femoral Artery; Glyburide; Heart Rate; Injections, Intravenous; Male; Mesenteric Arteries; Nitroglycerin; Oxadiazoles; Potassium Channels; Pyrroles; Renal Artery; Vascular Resistance; Vasodilator Agents | 1994 |
Drug-induced endothelium-dependent and -independent relaxations in isolated resistance vessels taken from simultaneously hypertensive and streptozotocin-diabetic rats.
Topics: Animals; Benzopyrans; Bradykinin; Calcium; Cromakalim; Diabetes Mellitus, Experimental; Endothelium, Vascular; Glyburide; Histamine; Hypertension; Male; Mesenteric Arteries; Methacholine Chloride; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Nitroprusside; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Streptozocin; Vascular Resistance; Vasodilation; Vasodilator Agents | 1994 |
Cardioprotective profile of the cardiac-selective ATP-sensitive potassium channel opener BMS-180448.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Aorta; Benzopyrans; Cromakalim; Decanoic Acids; Dogs; Female; Glyburide; Guanidines; Guinea Pigs; Heart; Heart Ventricles; Hydroxy Acids; In Vitro Techniques; Injections, Intravenous; Injections, Subcutaneous; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Myocardial Ischemia; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1995 |
Ventricular overdrive pacing-induced preconditioning and no-flow ischemia-induced preconditioning in isolated working rat hearts.
Topics: Animals; Benzopyrans; Blood Pressure; Cardiac Pacing, Artificial; Coronary Circulation; Cromakalim; Disease Models, Animal; Glyburide; Heart; In Vitro Techniques; Male; Myocardial Ischemia; Myocardial Reperfusion; Myocardial Reperfusion Injury; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Vasodilator Agents | 1995 |
Structure-activity relationship of glibenclamide analogs: a comparison of potency as levcromakalim antagonists in rat aorta vs. affinity for [3H]-glibenclamide binding to membranes from rat cerebral cortex.
Topics: Animals; Aorta; Benzopyrans; Binding Sites; Cell Membrane; Cerebral Cortex; Cromakalim; Glyburide; In Vitro Techniques; Male; Potassium Channels; Pyrroles; Rats; Rats, Inbred WKY; Structure-Activity Relationship; Vasodilator Agents | 1995 |
Cellular mechanisms of hypoxia-induced contraction in human and rat pulmonary arteries.
Topics: Aged; Animals; Benzopyrans; Calcium; Calcium Channels; Cromakalim; Glyburide; Humans; Hypoxia; In Vitro Techniques; Iodoacetates; Iodoacetic Acid; Male; Middle Aged; Muscle, Smooth, Vascular; Nifedipine; Potassium Channels; Pulmonary Artery; Pyrroles; Rats; Rats, Wistar; Vasoconstriction; Verapamil | 1995 |
Calcitonin gene-related peptide selectively increases cAMP levels in the guinea-pig ureter.
Topics: Animals; Benzopyrans; Calcitonin Gene-Related Peptide; Colforsin; Cromakalim; Cyclic AMP; Cyclic GMP; Drug Interactions; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Potassium Channels; Pyrroles; Ureter | 1995 |
Effects of potassium channel activators on isolated cerebral arteries of large and small diameter in the cat.
Topics: Animals; Benzopyrans; Cats; Cerebral Arteries; Cromakalim; Dihydropyridines; Dose-Response Relationship, Drug; Female; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Potassium Channels; Pyrroles; Uridine Triphosphate; Vasodilator Agents | 1995 |
Effects of glibenclamide on negative cardiac responses to cholinergic and purinergic stimuli and cromakalim in the isolated dog heart.
Topics: Acetylcholine; Adenosine; Adenosine Triphosphate; Analysis of Variance; Animals; Benzopyrans; Cholinergic Agonists; Cromakalim; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Glyburide; In Vitro Techniques; Myocardial Contraction; Parasympathetic Nervous System; Potassium Channels; Purinergic Agonists; Pyrroles; Receptors, Cholinergic; Receptors, Purinergic; Vasodilator Agents | 1994 |
Potentiation by insulin and insulin-like growth factor-1 of glibenclamide-sensitive K+ currents in follicle-enclosed Xenopus oocytes.
Topics: Animals; Antihypertensive Agents; Arsenicals; Benzopyrans; Cromakalim; Drug Synergism; Female; Glyburide; Insulin; Insulin-Like Growth Factor I; Oocytes; Patch-Clamp Techniques; Pertussis Toxin; Potassium Channels; Pyrroles; Virulence Factors, Bordetella; Xenopus laevis | 1994 |
Glibenclamide inhibits hypoxic relaxation of isolated porcine coronary arteries under conditions of impaired glycolysis.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Triphosphate; Animals; Benzopyrans; Coronary Vessels; Cromakalim; Deoxyglucose; Endothelium, Vascular; Glyburide; Glycolysis; Hypoxia; In Vitro Techniques; Indomethacin; Isometric Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Swine; Theophylline; Thromboxane A2; Vasoconstrictor Agents; Vasodilator Agents | 1994 |
Characterization of ATP-sensitive potassium channel-blocking activity of ZENECA ZM181,037, a eukalemic diuretic.
Topics: Acetamides; Adenosine Triphosphate; Administration, Oral; Animals; Benzopyrans; Blood Glucose; Blood Pressure; Cromakalim; Diuretics; Dogs; Dose-Response Relationship, Drug; Electrophysiology; Glyburide; Guinea Pigs; Hypertension; In Vitro Techniques; Injections, Intravenous; Male; Muscle Relaxation; Muscle, Smooth; Muscle, Smooth, Vascular; Potassium Channel Blockers; Pyrroles; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Stereoisomerism; Tolbutamide | 1994 |
Ionic dependence of adenosine uptake into cultured astrocytes.
Topics: Adenosine; Animals; Animals, Newborn; Astrocytes; Benzopyrans; Biological Transport; Calcimycin; Calcium; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cells, Cultured; Cerebral Cortex; Cromakalim; Furosemide; Glyburide; Ionophores; Kinetics; Mice; Niacinamide; Nicorandil; Nigericin; Omeprazole; Potassium; Pyrroles; Sodium; Valinomycin; Vasodilator Agents | 1994 |
Pharmacological analysis of the inhibitory effects of KRN2391 on endothelin-1-induced contraction in isolated large coronary artery of the pig.
Topics: Animals; Benzopyrans; Calcium; Coronary Vessels; Cromakalim; Dose-Response Relationship, Drug; Endothelins; Glyburide; In Vitro Techniques; Nitroglycerin; Potassium Channels; Pyridines; Pyrroles; Swine; Vasoconstriction; Vasodilator Agents | 1994 |
Regional and species differences in glyburide-sensitive K+ channels in airway smooth muscles as estimated from actions of KC 128 and levcromakalim.
Topics: Animals; Benzopyrans; Bronchi; Carbachol; Cromakalim; Dogs; Dose-Response Relationship, Drug; Female; Glyburide; Guinea Pigs; Humans; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Potassium Channels; Pyrroles; Species Specificity; Trachea | 1994 |
Activation of central ATP-sensitive potassium channels produces the antinociception and spinal noradrenaline turnover-enhancing effect in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenosine Triphosphate; Analgesics; Animals; Benzopyrans; Cromakalim; Glyburide; Injections, Intraventricular; Male; Methoxyhydroxyphenylglycol; Mice; Mice, Inbred Strains; Morphine; Norepinephrine; Parasympatholytics; Potassium Channels; Pyrroles; Pyrrolidines; Receptors, Opioid, kappa; Spinal Cord; Stimulation, Chemical | 1993 |
Reduction in ATP-sensitive potassium channel-mediated antinociception in diabetic mice.
Topics: Adenosine Triphosphate; Analgesics; Animals; Benzopyrans; Blood Glucose; Cromakalim; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glyburide; Male; Mice; Mice, Inbred ICR; Morphine; Pain Measurement; Potassium Channels; Pyrroles; Receptors, Opioid, mu; Tetraethylammonium Compounds | 1994 |
Effect of an ATP sensitive potassium channel opener, levcromakalim, on coronary arterial microvessels in the beating canine heart.
Topics: Animals; Benzopyrans; Capillaries; Coronary Vessels; Cromakalim; Dogs; Dose-Response Relationship, Drug; Glyburide; Hemodynamics; Microscopy, Fluorescence; Nitroprusside; Potassium Channels; Pyrroles; Vascular Resistance; Vasodilator Agents | 1994 |
Dilating effect of perivascularly applied potassium channel openers cromakalim and pinacidil in rat and cat pial arteries in situ.
Topics: Animals; Benzopyrans; Cats; Cerebral Arteries; Cromakalim; Female; Glyburide; Guanidines; Ion Channel Gating; Male; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1994 |
Multiple mechanisms in the smooth muscle relaxant action of calcitonin gene-related peptide (CGRP) in the guinea-pig ureter.
Topics: Action Potentials; Animals; Arginine; Benzopyrans; Calcitonin Gene-Related Peptide; Colforsin; Cromakalim; Dose-Response Relationship, Drug; Electric Stimulation; Glyburide; Guinea Pigs; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Muscle, Smooth; Nitroarginine; Parasympatholytics; Pyrroles; Ureter | 1994 |
Inhibition by histamine H1 receptor antagonists of endogenous glibenclamide-sensitive K+ channels in follicle-enclosed Xenopus oocytes.
Topics: Animals; Benzopyrans; Cromakalim; Female; Glyburide; Histamine H1 Antagonists; Membrane Potentials; Oocytes; Ovarian Follicle; Potassium; Potassium Channels; Pyrroles; Xenopus laevis | 1994 |
Guanosine diphosphate is required for activation of a glyburide, ATP and cromakalim-sensitive outward current in rat hippocampal neurones.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Bicuculline; Cells, Cultured; Cromakalim; Glyburide; Guanosine Diphosphate; Hippocampus; Ion Channel Gating; Kynurenic Acid; Neurons; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Tetrodotoxin | 1994 |
Effect of glibenclamide, forskolin, and isoprenaline on the parallel activation of KATP and reduction of IK by cromakalim in cardiac myocytes.
Topics: Animals; Benzopyrans; Cells, Cultured; Colforsin; Cromakalim; Glyburide; Guinea Pigs; Isoproterenol; Myocardium; Potassium Channels; Pyrroles; Sodium-Potassium-Exchanging ATPase; Vasodilator Agents | 1994 |
A glibenclamide sensitive potassium conductance in terminal arterioles isolated from guinea pig heart.
Topics: Action Potentials; Animals; Arterioles; Benzopyrans; Coronary Vessels; Cromakalim; Culture Techniques; Glyburide; Guinea Pigs; Membrane Potentials; Muscle, Smooth, Vascular; Potassium Channels; Pyrroles; Vasodilator Agents | 1994 |
Effect of lemakalim on action potentials, intracellular calcium, and contraction in guinea pig and human cardiac myocytes.
Topics: Action Potentials; Animals; Benzopyrans; Calcium; Cell Size; Cells, Cultured; Cromakalim; Dose-Response Relationship, Drug; Fura-2; Glyburide; Guinea Pigs; Heart; Humans; Intracellular Fluid; Male; Membrane Potentials; Myocardium; Pyrroles; Vasodilator Agents | 1994 |
Effect of potassium on the action of the KATP modulators cromakalim, pinacidil, or glibenclamide on arrhythmias in isolated perfused rat heart subjected to regional ischaemia.
Topics: Animals; Arrhythmias, Cardiac; Benzopyrans; Cromakalim; Glyburide; Guanidines; Heart; Heart Rate; Myocardial Ischemia; Myocardial Reperfusion Injury; Perfusion; Pinacidil; Potassium; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1994 |
The sensitivity of coronary vascular tone to glibenclamide: a study on the isolated perfused guinea pig heart.
Topics: Animals; Benzopyrans; Biological Assay; Coronary Vessels; Cromakalim; Glyburide; Guinea Pigs; Hypoxia; In Vitro Techniques; Muscle, Smooth, Vascular; Perfusion; Potassium Channels; Pyrroles; Vasodilator Agents | 1994 |
Pharmacological analysis of the effect of KRN2391 on coronary vasculature in perfused rat heart.
Topics: Animals; Benzopyrans; Coronary Circulation; Cromakalim; Dose-Response Relationship, Drug; Glyburide; In Vitro Techniques; Male; Nifedipine; Perfusion; Potassium Channels; Pyridines; Pyrroles; Rats; Rats, Wistar; Vasodilator Agents | 1994 |
Antagonism by lipophilic quaternary ions of the K+ channel opener, levcromakalim, in vascular smooth muscle.
Topics: Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Glyburide; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Onium Compounds; Organophosphorus Compounds; Potassium Channels; Pyrroles; Rats; Rats, Inbred WKY; Tetraphenylborate; Vasoconstriction; Vasodilation | 1994 |
Activation of ATP-sensitive potassium currents in guinea-pig gall-bladder smooth muscle by the neuropeptide CGRP.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcitonin Gene-Related Peptide; Cromakalim; Female; Gallbladder; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Microelectrodes; Muscle, Smooth; Patch-Clamp Techniques; Potassium Channels; Pyrroles; Tetraethylammonium Compounds | 1994 |
Mechanism of action of a K+ channel activator BRL 38227 on ATP-sensitive K+ channels in mouse skeletal muscle fibres.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Female; Glyburide; Male; Mice; Mice, Inbred C57BL; Muscle Fibers, Skeletal; Muscle, Skeletal; Patch-Clamp Techniques; Potassium Channels; Pyrroles | 1994 |
Mechanisms of vasorelaxation induced by N-allylsecoboldine in rat thoracic aorta.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Aorta, Thoracic; Aporphines; Benzopyrans; Calcium Channel Blockers; Cromakalim; Cyclic AMP; Cyclic GMP; Female; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Phosphatidylinositols; Potassium; Pyrroles; Rats; Rats, Wistar; Vasodilator Agents; Verapamil | 1994 |
Comparative effects of the potassium channel openers cromakalim and pinacidil and the cromakalim analog U-89232 on isolated vascular and cardiac tissue.
Topics: Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Female; Glyburide; Guanidines; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Myocardial Contraction; Pinacidil; Potassium Channels; Pyrroles; Rabbits; Vasodilator Agents | 1994 |
Cardioprotection with U-89232 is not reversible with glibenclamide: evidence of a novel anti-ischemic agent derived from cromakalim.
Topics: Animals; Benzopyrans; Cromakalim; Female; Glyburide; Guanidines; Heart; Hemodynamics; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Necrosis; Potassium Channels; Pyrroles; Rabbits; Vasodilator Agents | 1994 |
Effect of cromakalim and glibenclamide on spontaneous and evoked motility of the guinea-pig isolated renal pelvis and ureter.
Topics: Action Potentials; Animals; Benzopyrans; Cromakalim; Electrophysiology; Glyburide; Guinea Pigs; In Vitro Techniques; Kidney Pelvis; Male; Membrane Potentials; Muscle Contraction; Potassium Channels; Pyrroles; Ureter | 1994 |
Mechanisms of vasodilation of cerebral vessels induced by the potassium channel opener nicorandil in canine in vivo experiments.
Topics: Administration, Topical; Animals; Arterioles; Benzopyrans; Cromakalim; Dimethyl Sulfoxide; Dogs; Glyburide; Methylene Blue; Microcirculation; Niacinamide; Nicorandil; Nitroglycerin; Pia Mater; Pyrroles; Vasodilation; Vasodilator Agents; Venules | 1994 |
Effects of ATP-dependent K+ channel modulators on an ischemia-reperfusion rabbit isolated heart model with programmed electrical stimulation.
Topics: Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Benzopyrans; Blood Pressure; Coronary Circulation; Cromakalim; Electric Stimulation; Glyburide; Heart; In Vitro Techniques; Myocardial Ischemia; Myocardial Reperfusion Injury; Potassium Channels; Pyrroles; Rabbits; Refractory Period, Electrophysiological; Vasodilator Agents | 1994 |
The effects of racemic cromakalim, BRL 38226 and levcromakalim on the membrane potential of the rat aorta and of BRL 38226 on the contractile activity of the rat aorta and portal vein.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; Glyburide; In Vitro Techniques; Isoproterenol; Membrane Potentials; Muscle Contraction; Muscle, Smooth, Vascular; Portal Vein; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Wistar; Stereoisomerism; Vasoconstrictor Agents | 1994 |
K+ channel activators, acute glucose tolerance and glibenclamide-induced hypoglycaemia in the hypertensive rat.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Benzopyrans; Blood Glucose; Blood Pressure; Cromakalim; Diazoxide; Dose-Response Relationship, Drug; Glucose Tolerance Test; Glyburide; Guanidines; Hypertension; Hypoglycemia; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred SHR | 1994 |
Mechanism of the vasodilatory action of nicorandil on coronary circulation in dogs.
Topics: Animals; Benzopyrans; Coronary Circulation; Coronary Vessels; Cromakalim; Dogs; Dose-Response Relationship, Drug; Female; Glyburide; Hemodynamics; Injections, Intravenous; Male; Niacinamide; Nicorandil; Nitroglycerin; Potassium Channels; Pyrroles; Vasodilator Agents | 1994 |
Novel thieno[2,3-b]- and [3,4-b]pyrans as potassium channel openers. Thiophene systems--XVII.
Topics: Animals; Antihypertensive Agents; Aorta; Benzopyrans; Cromakalim; Drug Evaluation, Preclinical; Glyburide; Hypertension; In Vitro Techniques; Models, Molecular; Molecular Structure; Potassium Channels; Pyrroles; Rats; Rats, Inbred SHR; Structure-Activity Relationship; Thiophenes | 1993 |
Dissimilarity in the mechanisms of action of KRN2391, nicorandil and cromakalim in canine renal artery.
Topics: Animals; Benzopyrans; Cromakalim; Dogs; Female; Glyburide; In Vitro Techniques; Male; Methylene Blue; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitrates; Potassium Channels; Potassium Chloride; Pyridines; Pyrroles; Renal Artery; Vasodilator Agents | 1993 |
Effects of ATP-sensitive K(+)-channel activators on transmitter release parameters at the frog neuromuscular junction.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Diazoxide; Glyburide; In Vitro Techniques; Membrane Potentials; Motor Endplate; Muscles; Neuromuscular Junction; Neurotransmitter Agents; Parasympatholytics; Potassium Channels; Pyrroles; Rana pipiens | 1993 |
Mechanism of action of KRN2391 in canine coronary vascular bed.
Topics: Animals; Antihypertensive Agents; Arteries; Benzopyrans; Coronary Circulation; Coronary Vessels; Cromakalim; Dogs; Drug Interactions; Female; Glyburide; In Vitro Techniques; Male; Methylene Blue; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pyridines; Pyrroles; Vasodilator Agents | 1993 |
Pharmacological analysis of the vasodepressor effect of KRN2391 in pithed rats.
Topics: Animals; Benzopyrans; Blood Pressure; Cromakalim; Decerebrate State; Dose-Response Relationship, Drug; Glyburide; In Vitro Techniques; Male; Nitroglycerin; Potassium Channels; Pyridines; Pyrroles; Rats; Rats, Wistar; Vasodilator Agents | 1993 |
Effects of nicorandil on cytosolic calcium concentrations and on tension development in the rabbit femoral artery.
Topics: Animals; Benzopyrans; Calcium; Cromakalim; Cyclic GMP; Femoral Artery; Glyburide; In Vitro Techniques; Male; Niacinamide; Nicorandil; Nitroglycerin; Norepinephrine; Potassium; Potassium Channels; Pyrroles; Rabbits; Vasodilation; Vasodilator Agents | 1994 |
Effects of levcromakalim on ureteral peristaltic function and cystometrogram in rats.
Topics: Administration, Topical; Animals; Benzopyrans; Cromakalim; Glyburide; Injections, Intraperitoneal; Injections, Intravenous; Male; Nifedipine; Parasympatholytics; Pyrroles; Rats; Rats, Sprague-Dawley; Ureter; Urinary Bladder | 1993 |
Potassium channels are not involved in vasopressin-induced vasodilation in the rat lung.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arginine; Arginine Vasopressin; Barium; Benzopyrans; Cromakalim; Glyburide; In Vitro Techniques; Kinetics; Lung; Male; Muscle, Smooth, Vascular; Nitroarginine; Potassium Channel Blockers; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pulmonary Circulation; Pyrroles; Rats; Rats, Sprague-Dawley; Tetraethylammonium; Tetraethylammonium Compounds; Thromboxane A2; Vasoconstriction; Vasoconstrictor Agents; Vasodilation | 1994 |
Effects of trypsin on cardiac ATP-sensitive K+ channels.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Benzopyrans; Cells, Cultured; Cromakalim; Female; Glyburide; Glyoxal; Guinea Pigs; Heart; Magnesium; Male; Membrane Potentials; Phenylglyoxal; Potassium Channels; Pyrroles; Trypsin | 1994 |
Inhibition by SKF 525A and quinacrine of endogenous glibenclamide-sensitive K+ channels in follicle-enclosed Xenopus oocytes.
Topics: Animals; Benzopyrans; Cromakalim; Cytochrome P-450 Enzyme Inhibitors; Glyburide; Oocytes; Phospholipases A; Phospholipases A2; Potassium Channels; Proadifen; Pyrroles; Quinacrine; Xenopus laevis | 1994 |
Role of potassium channels in hypoxic relaxation of porcine bronchi in vitro.
Topics: Animals; Benzopyrans; Bronchi; Bronchodilator Agents; Carbachol; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Hypoxia; In Vitro Techniques; Isoproterenol; Muscle Relaxation; Potassium Channels; Pyrroles; Swine | 1994 |
Effects of K-channel openers on the contractility and electrical activity of antral circular muscle in guinea-pig stomach.
Topics: Action Potentials; Animals; Benzopyrans; Cromakalim; Glyburide; Guinea Pigs; In Vitro Techniques; Ion Channel Gating; Muscle Contraction; Muscle, Smooth; Niacinamide; Nicorandil; Potassium Channels; Pyrroles; Stomach | 1993 |
2-Deoxyglucose-induced vasodilation and hyperpolarization in rat coronary artery are reversed by glibenclamide.
Topics: Animals; Benzopyrans; Coronary Vessels; Cromakalim; Deoxyglucose; Dose-Response Relationship, Drug; Electrophysiology; Female; Glyburide; Male; Potassium Channel Blockers; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilation | 1994 |
Effects of antidiabetic sulphonylureas, cromakalim and their interaction in guinea-pig isolated tracheal smooth muscle.
Topics: Animals; Benzopyrans; Cromakalim; Drug Interactions; Glipizide; Glyburide; Guinea Pigs; Hypoglycemic Agents; Muscle Relaxation; Muscle, Smooth; Potassium Channels; Pyrroles; Sulfonylurea Compounds; Trachea | 1993 |
Cardioprotective effects of a novel calcium antagonist related to the structure of cromakalim.
Topics: Action Potentials; Animals; Benzopyrans; Calcium Channel Blockers; Coronary Circulation; Cromakalim; Glyburide; Heart; Hemodynamics; Male; Potassium Channels; Pyrroles; Quinolones; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sodium Channels | 1993 |
Synergistic effects of glyburide and U-37883A, two structurally different vascular ATP-sensitive potassium channel antagonists.
Topics: Adamantane; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Drug Synergism; Gallopamil; Glyburide; In Vitro Techniques; Ion Channel Gating; Male; Mesenteric Arteries; Minoxidil; Morpholines; Potassium Channels; Pyrroles; Rabbits; Vasodilation | 1993 |
ATP-sensitive potassium channels and skeletal muscle function in vitro.
Topics: Animals; Benzopyrans; Cromakalim; Electric Stimulation; Energy Metabolism; Gallamine Triethiodide; Glyburide; Guanidines; In Vitro Techniques; Ischemia; Male; Muscle Contraction; Muscles; Pinacidil; Potassium Channels; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley | 1993 |
Potassium channel blockade and halothane vasodilation in conducting and resistance coronary arteries.
Topics: Animals; Benzopyrans; Coronary Vessels; Cromakalim; Endothelium, Vascular; Glyburide; Halothane; In Vitro Techniques; Muscle, Smooth, Vascular; Potassium Channel Blockers; Potassium Channels; Pyrroles; Rats; Tetraethylammonium Compounds; Vasodilation | 1993 |
Arteriolar tone is determined by activity of ATP-sensitive potassium channels.
Topics: Adenosine Triphosphate; Animals; Arterioles; Benzopyrans; Bucladesine; Colforsin; Cricetinae; Cromakalim; Epoprostenol; Glyburide; Guanidines; Isoproterenol; Male; Mesocricetus; Methacholine Chloride; Muscle Tonus; Muscle, Smooth, Vascular; Muscles; Nitroprusside; Pinacidil; Potassium Channels; Pyrroles; Quaternary Ammonium Compounds; Vasoconstriction; Vasodilation; Vasodilator Agents | 1993 |
Nicorandil as a nitrate, and cromakalim as a potassium channel opener, dilate isolated porcine large coronary arteries in an agonist-nonselective manner.
Topics: Animals; Benzopyrans; Coronary Vessels; Cromakalim; Glyburide; In Vitro Techniques; Niacinamide; Nicorandil; Nitrates; Potassium Channels; Pyrroles; Swine; Vasodilator Agents | 1993 |
Single channel and whole-cell K-currents evoked by levcromakalim in smooth muscle cells from the rabbit portal vein.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Glyburide; Guanosine Diphosphate; In Vitro Techniques; Magnesium; Muscle, Smooth, Vascular; Portal Vein; Potassium Channels; Pyrroles; Rabbits; Tetraethylammonium Compounds; Vasodilator Agents | 1993 |
Differential effects of acetylcholine, nitric oxide and levcromakalim on smooth muscle membrane potential and tone in the rabbit basilar artery.
Topics: Acetylcholine; Animals; Basilar Artery; Benzopyrans; Cromakalim; Electrophysiology; Female; Glyburide; Humans; In Vitro Techniques; Infant, Newborn; Male; Membrane Potentials; Muscle Tonus; Muscle, Smooth, Vascular; Nitric Oxide; Norepinephrine; Potassium Channels; Potassium Chloride; Pyrroles; Rabbits; Vasodilator Agents | 1993 |
Endothelium-dependent hyperpolarization caused by bradykinin in human coronary arteries.
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Arginine; Benzopyrans; Bradykinin; Calcimycin; Child; Coronary Vessels; Cromakalim; Dinoprost; Endothelium, Vascular; Glyburide; Humans; In Vitro Techniques; Indoles; Indomethacin; Infant; Male; Membrane Potentials; Middle Aged; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroarginine; Pyrroles; Vasodilator Agents | 1993 |
Potassium channel openers and blockers: do they possess proarrhythmic or antiarrhythmic activity in ischemic and reperfused rat hearts?
Topics: Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Arrhythmias, Cardiac; Benzopyrans; Cations; Cromakalim; Glyburide; Heart; Ion Channel Gating; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley | 1993 |
Muscarinic inhibition of ATP-sensitive K+ channels by protein kinase C in urinary bladder smooth muscle.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Carbachol; Cromakalim; Diglycerides; Glyburide; Guanosine Diphosphate; Guinea Pigs; In Vitro Techniques; Indoles; Maleimides; Membrane Potentials; Muscarinic Antagonists; Muscle, Smooth; Potassium Channels; Protein Kinase C; Pyrroles; Receptors, Muscarinic; Tetradecanoylphorbol Acetate; Thionucleotides; Urinary Bladder | 1993 |
Adenosine triphosphate-sensitive potassium channel blocking agent ameliorates, but the opening agent aggravates, ischemia/reperfusion-induced injury. Heart function studies in nonfibrillating isolated hearts.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Guinea Pigs; Magnetic Resonance Spectroscopy; Male; Myocardial Reperfusion Injury; Myocardium; Potassium Channels; Pyrroles; Tachycardia, Ventricular; Ventricular Fibrillation | 1994 |
Attenuation by phentolamine of hypoxia and levcromakalim-induced abbreviation of the cardiac action potential.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Drug Interactions; Glucose; Glyburide; Guinea Pigs; Heart; Hypoxia; In Vitro Techniques; Kinetics; Papillary Muscles; Phentolamine; Potassium Channels; Pyrroles | 1993 |
Effects of KC 399, a novel ATP-sensitive K+ channel opener, on electrical and mechanical responses in dog tracheal smooth muscle.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Carbachol; Cromakalim; Cyclic AMP; Cyclic GMP; Dogs; Female; Glyburide; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Potassium Channels; Pyrroles; Trachea | 1994 |
Induction of a glibenclamide-sensitive K-current by modification of a delayed rectifier channel in rat portal vein in insulinoma cells.
Topics: Animals; Benzopyrans; Cromakalim; Glyburide; Insulinoma; Neurotoxins; Phosphorylation; Portal Vein; Potassium Channels; Pyrroles; Rats; Scorpion Venoms; Tumor Cells, Cultured | 1993 |
Antagonism of levcromakalim by imidazoline- and guanidine-derivatives in rat portal vein: involvement of the delayed rectifier.
Topics: Animals; Antazoline; Benzopyrans; Clonidine; Cromakalim; Glyburide; Guanabenz; Imidazoline Receptors; Male; Phentolamine; Portal Vein; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Drug | 1993 |
Mechanism of action of KRN2391, a novel vasodilator, in canine mesenteric artery.
Topics: Animals; Arterioles; Benzopyrans; Cromakalim; Dogs; Female; Glyburide; In Vitro Techniques; Male; Mesenteric Arteries; Methylene Blue; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pyridines; Pyrroles; Splanchnic Circulation; Vascular Resistance; Vasodilator Agents | 1993 |
Effects of potassium channel openers and their antagonists on rat locus coeruleus neurones.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Barium; Benzopyrans; Cromakalim; Electrophysiology; Glyburide; In Vitro Techniques; Kynurenic Acid; Locus Coeruleus; Male; Membrane Potentials; Neurons; Parasympatholytics; Potassium Channels; Pyridines; Pyrroles; Rats; Rats, Wistar; Substantia Nigra; Tetrodotoxin; Tolbutamide | 1993 |
Vasorelaxant mechanism of KRN2391 and nicorandil in porcine coronary arteries of different sizes.
Topics: Animals; Benzopyrans; Coronary Vessels; Cromakalim; Glyburide; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Oxyhemoglobins; Potassium Channels; Pyridines; Pyrroles; Swine; Vasodilator Agents | 1993 |
Pharmacological properties of ATP-sensitive K+ channels in mammalian skeletal muscle cells.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Electrophysiology; Glyburide; Guanidines; In Vitro Techniques; Mice; Muscles; Niacinamide; Nicorandil; Organic Chemicals; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1993 |
Comparative electrophysiological and mechanical actions of ATP-sensitive potassium channel openers in canine Purkinje fibers.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Dogs; Electrophysiology; Glyburide; Guanidines; In Vitro Techniques; Myocardial Contraction; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Purkinje Fibers; Pyrroles; Tetraethylammonium Compounds; Vasodilator Agents | 1993 |
Functional evidence for different endothelin receptors in the lung.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Anesthesia; Animals; Benzopyrans; Bradykinin; Cats; Cromakalim; Endothelins; Female; Glyburide; Hemodynamics; Lung; Male; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pulmonary Circulation; Pulmonary Gas Exchange; Pyrroles; Receptors, Endothelin; Tachyphylaxis; Vascular Resistance; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents; Viper Venoms | 1993 |
Lemakalim attenuates hypocapnia- and dry air-induced bronchoconstriction in canine peripheral airways.
Topics: Acetylcholine; Adenosine Triphosphate; Aerosols; Airway Resistance; Albuterol; Animals; Benzopyrans; Blood Pressure; Bronchoconstriction; Bronchodilator Agents; Cromakalim; Dogs; Glyburide; Heart Rate; Humidity; Hypocapnia; Injections, Intravenous; Lung; Male; Nifedipine; Potassium Channels; Pyrroles | 1993 |
The effects of (-)-cromakalim and glibenclamide on uptake2 in guinea-pig trachealis muscle.
Topics: Animals; Benzopyrans; Cromakalim; Female; Glyburide; Guinea Pigs; Isoproterenol; Male; Membrane Potentials; Muscle, Smooth; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Trachea | 1993 |
Effect of ouabain on relaxation induced by cromakalim in human and canine mesenteric arteries.
Topics: Adult; Animals; Benzopyrans; Cromakalim; Dogs; Female; Glyburide; Humans; Male; Mesenteric Arteries; Middle Aged; Muscle, Smooth, Vascular; Ouabain; Pyrroles; Rubidium Radioisotopes; Sensitivity and Specificity; Sodium Radioisotopes; Sodium-Potassium-Exchanging ATPase; Vasodilator Agents | 1993 |
Modification by cGMP of glibenclamide-sensitive K+ currents in Xenopus oocytes.
Topics: Animals; Benzopyrans; Cromakalim; Cyclic GMP; Female; Glyburide; In Vitro Techniques; Membrane Potentials; Methylene Blue; Niacinamide; Nicorandil; Nitroprusside; Oocytes; Potassium Channels; Pyridines; Pyrroles; Xenopus laevis | 1993 |
The antitussive effect of cromakalim in rats is not associated with adenosine triphosphate sensitive K+ channels.
Topics: Adenosine Triphosphate; Animals; Antitussive Agents; Benzopyrans; Calcium Channels; Capsaicin; Cough; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Injections, Intraperitoneal; Male; Methysergide; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Reflex; Tetraethylammonium Compounds | 1993 |
Possible involvement of K(ATP) channels in the control of 5-HT neurons.
Topics: Adenosine Triphosphate; Animals; Autoradiography; Benzopyrans; Cromakalim; Electrophysiology; GABA-A Receptor Antagonists; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Male; Neurons; Picolines; Potassium Channels; Pyrans; Pyrroles; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Antagonists; Sulfonylurea Compounds | 1993 |
The relaxant actions on guinea-pig trachealis of atherosperminine isolated from Fissistigma glaucescens.
Topics: Alkaloids; Animals; Benzopyrans; Calcium; Calmodulin; Colforsin; Cromakalim; Cyclic AMP; Cyclic GMP; Egtazic Acid; Epithelium; Female; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Nifedipine; Nitroprusside; Phenanthrenes; Plants, Medicinal; Propranolol; Pyrroles; Theophylline; Trachea; Vasodilator Agents | 1993 |
Effects of cromakalim on the electrical slow wave in the circular muscle of guinea-pig gastric antrum.
Topics: Animals; Benzopyrans; Cromakalim; Electrophysiology; Female; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Potassium; Pyloric Antrum; Pyrroles; Sodium | 1993 |
Inhibition of contractions of the isolated human myometrium by potassium channel openers.
Topics: Benzopyrans; Cromakalim; Female; Glyburide; Humans; Ion Channel Gating; Oxytocin; Parasympatholytics; Picolines; Potassium Channels; Potassium Chloride; Potassium Radioisotopes; Pregnancy; Pyrans; Pyrroles; Uterine Contraction | 1993 |
Activation by KRN2391 and nicorandil of glibenclamide-sensitive K+ channels in Xenopus oocytes.
Topics: Animals; Benzopyrans; Cromakalim; Electrophysiology; Epinephrine; Female; Glyburide; Niacinamide; Nicorandil; Oocytes; Phentolamine; Potassium Channels; Pyridines; Pyrroles; Trifluoperazine; Vasodilator Agents; Xenopus laevis | 1993 |
Effect of cromakalim on KCl-, noradrenaline- and angiotensin II-induced contractions in the rat pulmonary artery.
Topics: Angiotensin II; Animals; Benzopyrans; Bronchodilator Agents; Cromakalim; Glyburide; In Vitro Techniques; Isometric Contraction; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Phentolamine; Potassium Chloride; Pulmonary Artery; Pyrroles; Rats; Rats, Wistar; Tetraethylammonium Compounds | 1993 |
Relaxant effects of the potassium channel activators BRL 38227 and pinacidil on guinea-pig and human airway smooth muscle, and blockade of their effects by glibenclamide and BRL 31660.
Topics: Animals; Anti-Arrhythmia Agents; Benzopyrans; Bronchi; Cromakalim; Female; Glyburide; Guanidines; Guinea Pigs; Histamine; Humans; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Pinacidil; Potassium; Potassium Channels; Potassium Radioisotopes; Pyrroles; Pyrrolidines; Respiratory System; Trachea; Vasodilator Agents | 1993 |
Selective and complete blockade of acetylcholine-induced relaxation in rabbit aortic rings by N omega-nitro-L-arginine but not by glybenclamide.
Topics: Acetylcholine; Animals; Aorta, Abdominal; Arginine; Benzopyrans; Cromakalim; Endothelium, Vascular; Glyburide; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroarginine; Nitroglycerin; Pyrroles; Rabbits; Vasodilator Agents | 1993 |
Inhibitory effect of cromakalim in human detrusor muscle is mediated by glibenclamide-sensitive potassium channels.
Topics: Benzopyrans; Cromakalim; Depression, Chemical; Dose-Response Relationship, Drug; Glyburide; Humans; In Vitro Techniques; Male; Muscle Contraction; Potassium Channels; Pyrroles; Urinary Bladder | 1993 |
Mechanisms of oxygen-induced contraction of ductus arteriosus isolated from the fetal rabbit.
Topics: Animals; Benzopyrans; Calcium; Cromakalim; Diltiazem; Ductus Arteriosus; Glyburide; In Vitro Techniques; Nickel; Norepinephrine; Oxygen; Potassium; Pyrroles; Rabbits; Vasoconstriction; Verapamil | 1993 |
Modulation of rabbit aortic Ca(2+)-activated K+ channels by pinacidil, cromakalim, and glibenclamide.
Topics: Animals; Aorta; Benzopyrans; Calcium; Cations; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Guanidines; Lipid Bilayers; Membrane Potentials; Microsomes; Muscle, Smooth, Vascular; Pinacidil; Potassium Channels; Pyrroles; Rabbits; Vasodilator Agents | 1993 |
ATP-sensitive potassium channels in smooth muscle cells from guinea pig urinary bladder.
Topics: 2,4-Dinitrophenol; Adenosine Triphosphate; Analysis of Variance; Animals; Barium; Benzopyrans; Cromakalim; Deoxyglucose; Dinitrophenols; Glyburide; Guinea Pigs; In Vitro Techniques; Ion Channel Gating; Kinetics; Male; Membrane Potentials; Models, Biological; Muscle, Smooth; Potassium Channels; Pyrroles; Tetraethylammonium; Tetraethylammonium Compounds; Urinary Bladder; Vasodilator Agents | 1993 |
8-(Diethylamino)-octyl-3,4,5-trimethoxybenzoate inhibits cromakalim-induced 86Rb efflux from the rat aorta.
Topics: Animals; Aorta; Benzopyrans; Biological Transport; Cromakalim; Gallic Acid; Glyburide; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Sprague-Dawley; Rubidium | 1993 |
BRL 38227 (levcromakalim)-induced hyperpolarization reduces the sensitivity to Ca2+ of contractile elements in canine coronary artery.
Topics: Animals; Benzopyrans; Calcium; Cromakalim; Dogs; Dose-Response Relationship, Drug; Female; Glyburide; Heart; Male; Membrane Potentials; Potassium Channels; Potassium Chloride; Pyrroles; Vasoconstriction; Vasodilator Agents | 1993 |
Diabetes and ATP-sensitive potassium channel openers and blockers in isolated ischemic/reperfused hearts.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzopyrans; Cations; Cromakalim; Diabetes Mellitus, Experimental; Glyburide; Heart Function Tests; Hypoglycemic Agents; In Vitro Techniques; Male; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Potassium Channel Blockers; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Streptozocin | 1995 |
Glibenclamide does not reverse attenuated vasoreactivity to acute or chronic hypoxia.
Topics: Acute Disease; Adenosine Triphosphate; Animals; Benzopyrans; Blood Gas Analysis; Blood Pressure; Chronic Disease; Cromakalim; Glyburide; Heart Rate; Hemodynamics; Hypoglycemic Agents; Hypoxia; Male; Phenylephrine; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Vascular Resistance; Vasoconstrictor Agents | 1995 |
K+ channel-opening properties of a novel compound, NIP-121, in guinea pig myocardium as compared with those of cromakalim.
Topics: Action Potentials; Adenosine Triphosphate; Analysis of Variance; Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Guinea Pigs; Hypoglycemic Agents; Muscle Relaxation; Muscle, Smooth, Vascular; Myocardial Contraction; Myocardium; Oxadiazoles; Papillary Muscles; Patch-Clamp Techniques; Piperidines; Potassium Channels; Pyrroles; Vasodilator Agents | 1995 |
Glyburide-reversible cardioprotective effect of BMS-180448 is independent of action potential shortening.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Female; Glyburide; Guanidines; Guinea Pigs; In Vitro Techniques; Ion Channel Gating; Male; Membrane Potentials; Myocardial Infarction; Myocardial Ischemia; Perfusion; Potassium Channels; Pyrroles; Vasodilator Agents | 1995 |
KATP channel modulation in working rat hearts with coronary occlusion: effects of cromakalim, cicletanine, and glibenclamide.
Topics: Animals; Anti-Arrhythmia Agents; Benzopyrans; Coronary Circulation; Coronary Disease; Cromakalim; Glyburide; Heart; Ion Channel Gating; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Potassium Channels; Pyridines; Pyrroles; Rats; Rats, Wistar; Ventricular Fibrillation | 1995 |
Impaired action of levcromakalim on ATP-sensitive K+ channels in mesenteric artery cells from spontaneously hypertensive rats.
Topics: Animals; Benzopyrans; Blood Pressure; Body Weight; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Hydralazine; Membrane Potentials; Mesenteric Arteries; Parasympatholytics; Patch-Clamp Techniques; Potassium Channels; Pulse; Pyrroles; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Species Specificity | 1996 |
Effects of potassium channel modulators cromakalim, tetraethylammonium and glibenclamide on the contractility of the isolated human ureter.
Topics: Benzopyrans; Cromakalim; Glyburide; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Potassium Channels; Potassium Chloride; Pyrroles; Tetraethylammonium; Tetraethylammonium Compounds; Ureter | 1996 |
Endothelin-1 partially inhibits ATP-sensitive K+ current in guinea pig ventricular cells.
Topics: Action Potentials; Adenosine Triphosphate; Alkaloids; Animals; Azepines; Benzopyrans; Cromakalim; Endothelin Receptor Antagonists; Endothelins; Female; Glyburide; Guinea Pigs; Heart; Heart Ventricles; Hypoglycemic Agents; Male; Niacinamide; Nicorandil; Oligopeptides; Papillary Muscles; Potassium Channels; Protein Kinase C; Pyrroles; Staurosporine; Sulfonamides; Vasodilator Agents | 1996 |
The involvement of ATP-sensitive potassium channels and adenosine in the regulation of coronary flow in the isolated perfused rat heart.
Topics: Adenosine; Adenosine Triphosphate; Animals; Benzopyrans; Coronary Circulation; Cromakalim; Glyburide; Heart; In Vitro Techniques; Male; Perfusion; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Theophylline; Vasoconstrictor Agents; Vasodilator Agents | 1995 |
Lack of a pharmacologic interaction between ATP-sensitive potassium channels and adenosine A1 receptors in ischemic rat hearts.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Male; Myocardial Ischemia; Myocardium; Perfusion; Phenylisopropyladenosine; Potassium Channels; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Xanthines | 1996 |
The lack of a role for potassium channel opening in the action of relaxin in the rat isolated uterus; a comparison with levcromakalim and salbutamol.
Topics: Adrenergic beta-Agonists; Albuterol; Animals; Benzopyrans; Cromakalim; Electrophysiology; Female; Glyburide; In Vitro Techniques; Oxytocin; Parasympatholytics; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Sprague-Dawley; Relaxin; Uterine Contraction; Uterus | 1996 |
Two types of ATP-sensitive potassium channels in rat portal vein smooth muscle cells.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cells, Cultured; Cromakalim; Glyburide; Guanidines; Male; Membrane Potentials; Muscle, Smooth, Vascular; Pinacidil; Portal Vein; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Sensitivity and Specificity; Uridine Diphosphate | 1996 |
Effects of cromakalim, pinacidil and glibenclamide on cholinergic transmission in rat isolated atria.
Topics: Acetylcholine; Analysis of Variance; Animals; Benzopyrans; Cholinergic Fibers; Cromakalim; Female; Glyburide; Guanidines; Heart; Hypoglycemic Agents; Male; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1995 |
Activation by levcromakalim and metabolic inhibition of glibenclamide-sensitive K channels in smooth muscle cells of pig proximal urethra.
Topics: Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Female; Glyburide; Membrane Potentials; Muscle, Smooth; Potassium Channels; Pyrroles; Swine; Urethra; Vasodilator Agents | 1996 |
The effects of pharmacological modulation of KATP on the guinea-pig isolated diaphragm.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Diaphragm; Electrophysiology; Glyburide; Guanidines; Guinea Pigs; Indoles; Male; Membrane Potentials; Muscle Contraction; Muscle Tonus; Phentolamine; Pinacidil; Potassium Channels; Pyrroles | 1996 |
In vitro hypoxia on rat pulmonary artery: effects on contractions to spasmogens and role of KATP channels.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Benzopyrans; Cromakalim; Drug Interactions; Glyburide; Hypoxia; In Vitro Techniques; Male; Potassium Channel Blockers; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pulmonary Artery; Pyrroles; Rats; Rats, Wistar; Thromboxane A2; Vasoconstrictor Agents | 1996 |
Identification and properties of an ATP-sensitive K+ current in rabbit sino-atrial node pacemaker cells.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Glyburide; Guanidines; Hydrogen-Ion Concentration; Kinetics; Myocardium; Patch-Clamp Techniques; Pinacidil; Potassium; Potassium Channel Blockers; Potassium Channels; Pyrroles; Rabbits; Sinoatrial Node; Sodium Cyanide; Vasodilator Agents | 1996 |
Effects of glibenclamide on the regional haemodynamic actions of alpha-trinositol and its influence on responses to vasodilators in conscious rats.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Benzopyrans; Blood Glucose; Bradykinin; Cromakalim; Glyburide; Hemodynamics; Hindlimb; Hypoglycemic Agents; Inositol Phosphates; Male; Nitroprusside; Platelet Aggregation Inhibitors; Potassium Channels; Pyrroles; Rats; Regional Blood Flow; Renal Circulation; Splanchnic Circulation; Vasodilator Agents | 1996 |
Three components of potassium outward current in cells isolated from the circular layer of guinea-pig ileum.
Topics: Animals; Apamin; Benzopyrans; Cromakalim; Glyburide; Guinea Pigs; Ileum; Male; Membrane Potentials; Muscle, Smooth; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels; Pyrroles | 1995 |
Implication of ATP-sensitive K+ channels in various stress-induced analgesia (SIA) in mice.
Topics: Adenosine Triphosphate; Analgesia; Animals; Benzopyrans; Cromakalim; Glyburide; Male; Mice; Potassium Channels; Pyrroles; Stress, Physiological | 1996 |
Pharmacodynamic behaviour of isolated resistance vessels obtained from hypertensive-diabetic rats.
Topics: Animals; Benzopyrans; Blood Glucose; Calcium Channels; Calcium Chloride; Cromakalim; Glyburide; Hypertension; In Vitro Techniques; Male; Mesenteric Arteries; Methacholine Chloride; Methoxamine; Muscle Contraction; Muscle, Smooth; Nifedipine; Nitroprusside; Norepinephrine; Obesity; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Zucker; Serotonin; Tunica Media; Vascular Resistance; Vasoconstrictor Agents; Vasodilator Agents | 1996 |
Effects of SCA40 on human bronchi and on guinea pig main bronchi in vitro. Comparison with cromakalim.
Topics: Acetylcholine; Animals; Benzopyrans; Bronchi; Bronchodilator Agents; Capsaicin; Charybdotoxin; Cromakalim; Electric Stimulation; Female; Glyburide; Guinea Pigs; Humans; Imidazoles; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Neurokinin A; Nitroprusside; Osmolar Concentration; Parasympatholytics; Potassium Channel Blockers; Potassium Channels; Pyrazines; Pyrroles; Tetraethylammonium; Tetraethylammonium Compounds | 1996 |
Anti- and proconvulsive actions of levcromakalim, an opener of ATP-sensitive K+ channel, in the model of hippocampus-generating partial seizures in rats.
Topics: Adenosine Triphosphate; Animals; Anticonvulsants; Benzopyrans; Calcium Channel Agonists; Calcium Channel Blockers; Convulsants; Cromakalim; Dentate Gyrus; Electric Stimulation; Electroencephalography; Epilepsies, Partial; Glyburide; Hippocampus; Hypoglycemic Agents; Injections, Intraventricular; Male; Patch-Clamp Techniques; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Tetraethylammonium Compounds; Tumor Cells, Cultured | 1996 |
Effects of cromakalim and glibenclamide in ischemic and reperfused hearts.
Topics: Animals; Anti-Arrhythmia Agents; Benzopyrans; Cromakalim; Diabetes Mellitus, Experimental; Glyburide; In Vitro Techniques; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Pyrroles; Rats; Rats, Sprague-Dawley | 1996 |
Role of activation of ectosolic 5'-nucleotidase in the cardioprotection mediated by opening of K+c channels.
Topics: 5'-Nucleotidase; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Dogs; Enzyme Activation; Glyburide; Heart; Hemodynamics; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Niacinamide; Nicorandil; Potassium Channels; Pyrroles; Recurrence | 1996 |
Zeneca ZD6169 activates ATP-sensitive K+ channels in the urinary bladder of the guinea pig.
Topics: Adenosine Triphosphate; Amides; Animals; Benzophenones; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Enzyme Activation; Glyburide; Guinea Pigs; Hydrogen-Ion Concentration; In Vitro Techniques; Ion Channel Gating; Membrane Potentials; Muscle, Smooth; Potassium Channels; Protein Kinase C; Pyrroles; Urinary Bladder | 1996 |
The relaxant effect of extract of Phyllanthus urinaria in the guinea-pig isolated trachea. Evidence for involvement of ATP-sensitive potassium channels.
Topics: Adenosine Triphosphate; Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Animals; Apamin; Benzopyrans; Calcitonin Gene-Related Peptide; Calcium; Cromakalim; Dose-Response Relationship, Drug; Female; Glyburide; Guinea Pigs; Hypoglycemic Agents; Male; Muscle Relaxation; Muscle, Smooth; Norepinephrine; Plant Extracts; Plants, Medicinal; Potassium Channels; Potassium Chloride; Propranolol; Pyrroles; Tetraethylammonium; Tetraethylammonium Compounds; Trachea | 1996 |
KATP channels mediate adenosine-induced hyperemia in retina.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Adenosine Triphosphate; Adenylyl Cyclases; Animals; Benzopyrans; Colforsin; Cromakalim; Cyclic AMP; Dose-Response Relationship, Drug; Fluorescein Angiography; Glyburide; Hyperemia; Muscle, Smooth, Vascular; Potassium Channel Blockers; Potassium Channels; Pyrroles; Regional Blood Flow; Retinal Vessels; Second Messenger Systems; Signal Transduction; Swine; Vasodilation; Vasodilator Agents | 1996 |
Analysis of relaxation and repolarization mechanisms of nicorandil in rat mesenteric artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Benzopyrans; Calcium Channel Blockers; Cromakalim; Electrophysiology; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Male; Membrane Potentials; Mesenteric Arteries; Methylene Blue; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nifedipine; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Rats; Rats, Sprague-Dawley; Thromboxane A2; Vasoconstrictor Agents; Vasodilator Agents | 1996 |
Relaxant effect of levcromakalim in isolated human small subcutaneous arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Triphosphate; Adolescent; Adult; Arteries; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Drug Interactions; Female; Glyburide; Humans; In Vitro Techniques; Methacholine Chloride; Middle Aged; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Skin; Thromboxane A2; Vasoconstrictor Agents | 1995 |
Nicorandil activates glibenclamide-sensitive K+ channels in smooth muscle cells of pig proximal urethra.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Cyclic GMP; Female; Glyburide; Membrane Potentials; Muscle, Smooth; Niacinamide; Nicorandil; Potassium Channels; Pyrroles; Swine; Urethra | 1997 |
Regional hemodynamic dose-response of lemakalim and glybenclamide in anesthetized rats.
Topics: Adenosine Triphosphate; Anesthesia; Animals; Benzopyrans; Blood Circulation; Blood Pressure; Coronary Circulation; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Hindlimb; Male; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Renal Circulation; Splanchnic Circulation; Vascular Resistance | 1997 |
ATP-sensitive potassium channels in isolated rat aorta during physiologic, hypoxic, and low-glucose conditions.
Topics: Adenosine Triphosphate; Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Endothelium, Vascular; Glyburide; Hypoglycemia; Hypoxia; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents | 1997 |
Cromakalim blocks the purinergic response evoked in rat vas deferens by single-pulse electrical stimulation.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Electric Stimulation; Glyburide; Male; Norepinephrine; Potassium Channels; Prazosin; Pyrroles; Rats; Rats, Wistar; Suramin; Vas Deferens | 1997 |
Endothelium-mediated and N omega-nitro-L-arginine methyl ester-sensitive responses to cromakalim and diazoxide in the rat mesenteric bed.
Topics: Adrenergic alpha-Agonists; Animals; Benzopyrans; Cromakalim; Diazoxide; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Hypoglycemic Agents; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Norepinephrine; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Wistar; Splanchnic Circulation; Vascular Resistance; Vasodilator Agents | 1997 |
Hypoxic dilatation of porcine small coronary arteries: role of endothelium and KATP-channels.
Topics: Animals; Benzopyrans; Cell Hypoxia; Coronary Vessels; Cromakalim; Endothelium, Vascular; Glyburide; In Vitro Techniques; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Potassium Channels; Pyrroles; Swine; Vasodilation | 1997 |
Hypoxia-induced hyperpolarization is not associated with vasodilation of bovine coronary resistance arteries.
Topics: Acetylcholine; Animals; Benzopyrans; Bradykinin; Calcium; Cattle; Coronary Vessels; Cromakalim; Endothelium, Vascular; Glyburide; Hypoxia; In Vitro Techniques; Membrane Potentials; Microelectrodes; Microscopy, Video; Oxygen; Perfusion; Pyrroles; Vascular Resistance; Vasodilation; Vasodilator Agents | 1997 |
Cardiovascular responses to glibenclamide during endotoxaemia in the pig.
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Benzopyrans; Blood Pressure; Cardiac Output; Cardiovascular Physiological Phenomena; Cardiovascular System; Cromakalim; Endotoxemia; Endotoxins; Female; Glyburide; Hemodynamics; Hydrogen-Ion Concentration; Hypoglycemic Agents; Infusion Pumps; Infusions, Intravenous; Injections; Male; Potassium Channels; Pyrroles; Swine; Swine Diseases; Time Factors; Vascular Resistance | 1997 |
Halothane and enflurane attenuate pulmonary vasodilation mediated by adenosine triphosphate-sensitive potassium channels compared to the conscious state.
Topics: Adenosine Triphosphate; Anesthetics, Inhalation; Animals; Benzopyrans; Consciousness; Cromakalim; Dogs; Dose-Response Relationship, Drug; Enflurane; Glyburide; Halothane; Male; Potassium Channels; Pulmonary Circulation; Pyrroles; Vasodilation | 1997 |
Effects of levcromakalim and nucleoside diphosphates on glibenclamide-sensitive K+ channels in pig urethral myocytes.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Female; Glyburide; In Vitro Techniques; Magnesium; Muscle, Smooth; Potassium Channels; Pyrroles; Swine; Urethra; Uridine Diphosphate | 1997 |
Modulation of K+ channels by intracellular ATP in human neocortical neurons.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cerebral Cortex; Cromakalim; Electrophysiology; Glyburide; Humans; Hypoglycemic Agents; In Vitro Techniques; Membrane Potentials; Neurons; Patch-Clamp Techniques; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley | 1997 |
Evaluation of BTS 67 582, a novel antidiabetic agent, in normal and diabetic rats.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Blood Glucose; Brain; Cromakalim; Diabetes Mellitus, Experimental; Diazoxide; Glucose; Glyburide; Guanidines; Hypoglycemic Agents; In Vitro Techniques; Insulin; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Channel Blockers; Pyrroles; Rats; Rats, Wistar; Tumor Cells, Cultured | 1997 |
KATP channel modulators increase survival rate during coronary occlusion-reperfusion in anaesthetized rats.
Topics: Action Potentials; Adenosine Triphosphate; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzopyrans; Blood Pressure; Calcium Channel Blockers; Coronary Disease; Cromakalim; Disease Models, Animal; Dose-Response Relationship, Drug; Electrocardiography; Glyburide; Guanidines; Heart Rate; Male; Myocardial Reperfusion Injury; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Survival Rate; Vasodilator Agents; Ventricular Fibrillation | 1997 |
The thromboxane A2 and K(ATP) channel antagonist actions of a series of sulphonylurea derivatives in the pig coronary artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Benzopyrans; Coronary Vessels; Cromakalim; Glyburide; Onium Compounds; Organophosphorus Compounds; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Structure-Activity Relationship; Swine; Thromboxane A2; Vasoconstrictor Agents; Vasodilator Agents | 1997 |
Effects of putative K+ channel blockers on beta-adrenoceptor-mediated vasorelaxation of rat mesenteric artery.
Topics: Adenosine Triphosphate; Adrenergic beta-Agonists; Animals; Barium; Benzopyrans; Calcium; Charybdotoxin; Colforsin; Cromakalim; Cyclic AMP; Dose-Response Relationship, Drug; Fenoterol; Glyburide; Isoproterenol; Male; Mesenteric Arteries; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Phenylephrine; Potassium Channel Blockers; Pyrroles; Rats; Rats, Sprague-Dawley; Vasoconstrictor Agents; Vasodilator Agents | 1997 |
Characterization of ATP-sensitive potassium channels in freshly dissociated rabbit aortic endothelial cells.
Topics: Adenosine Triphosphate; Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; Electric Conductivity; Endothelium, Vascular; Glyburide; In Vitro Techniques; Ion Channel Gating; Patch-Clamp Techniques; Potassium; Potassium Channels; Pyrroles; Rabbits | 1997 |
Hypoxia-induced catecholamine release and intracellular Ca2+ increase via suppression of K+ channels in cultured rat adrenal chromaffin cells.
Topics: Animals; Benzopyrans; Buffers; Calcium; Carotid Body; Catecholamines; Cell Hypoxia; CHO Cells; Chromaffin Cells; Cricetinae; Cromakalim; Diazoxide; Glioma; Glyburide; Guanidines; Hybrid Cells; Hypoglycemic Agents; Male; Membrane Potentials; Minoxidil; Neuroblastoma; Parasympatholytics; Patch-Clamp Techniques; Pinacidil; Potassium; Potassium Channel Blockers; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Vasodilator Agents | 1997 |
Effects of cromakalim and glibenclamide on myocardial high energy phosphates and intracellular pH during ischemia-reperfusion: 31P NMR studies.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Benzopyrans; Coronary Circulation; Cromakalim; Decanoic Acids; Dose-Response Relationship, Drug; Glyburide; Hydrogen-Ion Concentration; Hydroxy Acids; Hypoglycemic Agents; In Vitro Techniques; Lactates; Magnetic Resonance Spectroscopy; Male; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Phosphorus Isotopes; Pyrroles; Rats; Rats, Sprague-Dawley | 1997 |
Capacitative Ca2+ entry associated with alpha1-adrenoceptors in rat aorta.
Topics: Animals; Aorta; Benzopyrans; Calcium; Calcium Channel Blockers; Calcium Channels; Cromakalim; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle Tonus; Nimodipine; Norepinephrine; Potassium Channel Blockers; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Tetraethylammonium Compounds | 1997 |
Heterogeneity in the vasorelaxing effect of nicorandil on dog epicardial coronary arteries: comparison with other NO donors.
Topics: Animals; Atrial Natriuretic Factor; Benzopyrans; Coronary Vessels; Cromakalim; Cyclic GMP; Dogs; Female; Glyburide; In Vitro Techniques; Male; Methylene Blue; Molsidomine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitric Oxide; Nitroglycerin; Nitroprusside; Oxyhemoglobins; Pyrroles; Vasodilator Agents | 1997 |
Possible involvement of ATP-dependent K-channel related mechanisms in the antihypertensive and cough suppressant effects of the novel ACE inhibitor (2S, 3aS, 7aS)-1-(N2-nicotinoyl-L-lysyl-gamma-D-glutamyl)octahydro-1H- indole-2-carboxylic acid.
Topics: Adenosine Triphosphate; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Antitussive Agents; Aorta, Thoracic; Benzopyrans; Blood Pressure; Cromakalim; Dipeptides; Glyburide; Guinea Pigs; In Vitro Techniques; Indoles; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Rats, Wistar | 1997 |
The comparison of the responsiveness of human isolated internal mammary and gastroepiploic arteries to levcromakalim: an alternative approach to the management of graft spasm.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Arteries; Benzopyrans; Coronary Artery Bypass; Cromakalim; Endothelin-1; Female; Glyburide; Humans; In Vitro Techniques; Indomethacin; Male; Mammary Arteries; Middle Aged; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroarginine; Norepinephrine; Omentum; Potassium; Potassium Channel Blockers; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Stomach; Thromboxane A2; Vasoconstrictor Agents; Vasodilator Agents | 1997 |
Vasodilator responses to acetylcholine, bradykinin, and substance P are mediated by a TEA-sensitive mechanism.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholine; Albuterol; Alprostadil; Analysis of Variance; Angiotensin II; Animals; Benzopyrans; Blood Pressure; Bradykinin; Cats; Cromakalim; Endothelium, Vascular; Female; Glyburide; Heart Rate; Hindlimb; Hydrazines; Isradipine; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitrogen Oxides; Nitroprusside; Norepinephrine; Penicillamine; Prostaglandin Endoperoxides, Synthetic; Pyrroles; S-Nitroso-N-Acetylpenicillamine; Substance P; Tetraethylammonium; Tetraethylammonium Compounds; Thromboxane A2; Vasoactive Intestinal Peptide; Vasodilation; Vasodilator Agents | 1997 |
ATP-dependent K+ channel activation in isolated normal and hypertensive newborn and adult porcine pulmonary vessels.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Antihypertensive Agents; Cromakalim; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Endothelium; Enzyme Inhibitors; Female; Glyburide; Hypertension, Pulmonary; Hypoglycemic Agents; Hypoxia; In Vitro Techniques; Indomethacin; omega-N-Methylarginine; Potassium Channel Blockers; Potassium Channels; Prostaglandins; Pulmonary Artery; Pulmonary Veins; Sensitivity and Specificity; Swine | 1997 |
Activity of glibenclamide-sensitive K+ channels under unstimulated conditions in smooth muscle cells of pig proximal urethra.
Topics: Animals; Cromakalim; Female; Glyburide; In Vitro Techniques; Membrane Potentials; Muscle, Smooth; Patch-Clamp Techniques; Potassium Channels; Swine; Urethra | 1997 |
Mechanism of hypoxic K loss in rabbit ventricle.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Biological Transport; Cromakalim; Glyburide; Heart Ventricles; Hypoxia; In Vitro Techniques; Ion Channel Gating; Male; Models, Biological; Myocardial Ischemia; Potassium; Potassium Channel Blockers; Potassium Channels; Rabbits; Sodium | 1997 |
Halothane attenuates endothelium-dependent pulmonary vasorelaxant response to lemakalim, an adenosine triphosphate (ATP)-sensitive potassium channel agonist.
Topics: Adenosine Triphosphate; Anesthetics, Inhalation; Animals; Benzopyrans; Cromakalim; Dogs; Endothelium, Vascular; Glyburide; Halothane; Humans; Indomethacin; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Potassium Channels; Pulmonary Artery; Pyrroles; Vasodilation; Vasodilator Agents | 1997 |
Role of ATP-sensitive potassium channels in brain stem circulation during hypotension.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Arterioles; ATP-Binding Cassette Transporters; Basilar Artery; Benzopyrans; Blood Pressure; Brain Stem; Carbon Dioxide; Coronary Circulation; Cromakalim; Glyburide; Homeostasis; Hypotension; KATP Channels; Male; Oxygen; Partial Pressure; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilation | 1997 |
The potassium channel opener (-)-cromakalim prevents glutamate-induced cell death in hippocampal neurons.
Topics: Animals; Apoptosis; Calcium; Cell Death; Cells, Cultured; Cromakalim; Glutamic Acid; Glyburide; Hippocampus; Necrosis; Neurons; Osmolar Concentration; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Stereoisomerism | 1997 |
Relaxin as a relaxant of the isolated rat uterus: comparison with its mechanism of action in vivo.
Topics: Albuterol; Animals; Cromakalim; Female; Glyburide; Hormones; In Vitro Techniques; Ovariectomy; Rats; Rats, Sprague-Dawley; Relaxin; Stereoisomerism; Uterine Contraction | 1997 |
Acceleration of stiffness in underperfused diabetic rat hearts by glyburide, a KATP channel blocker, and its prevention by levcromakalim and insulin.
Topics: Animals; Anti-Arrhythmia Agents; Coronary Circulation; Cromakalim; Diabetes Mellitus, Experimental; Glyburide; Hypoglycemic Agents; Insulin; Male; Myocardial Contraction; Norepinephrine; Perfusion; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley | 1997 |
KATP channels contribute to beta- and adenosine receptor-mediated pulmonary vasorelaxation.
Topics: Acetylcholine; Adenosine; Adenylyl Cyclases; Animals; ATP-Binding Cassette Transporters; Colforsin; Cromakalim; Cyclic AMP; Cyclic GMP; Glyburide; In Vitro Techniques; Isoproterenol; KATP Channels; Kinetics; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroprusside; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Receptors, Purinergic P1; Tolbutamide; Vasodilation | 1997 |
Angiotensin II inhibition of ATP-sensitive K+ currents in rat arterial smooth muscle cells through protein kinase C.
Topics: Adenosine Triphosphate; Angiotensin II; Animals; Cromakalim; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Diglycerides; Enzyme Inhibitors; Glyburide; Guanosine Diphosphate; Hypoglycemic Agents; Male; Membrane Potentials; Mesenteric Arteries; Muscle, Smooth, Vascular; Naphthalenes; Patch-Clamp Techniques; Potassium; Potassium Channel Blockers; Potassium Channels; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Thionucleotides; Vasoconstrictor Agents; Vasodilator Agents | 1997 |
Binding and effects of KATP channel openers in the vascular smooth muscle cell line, A10.
Topics: Animals; Aorta, Thoracic; Binding, Competitive; Cell Line; Cromakalim; Glyburide; Guanidines; Membrane Potentials; Minoxidil; Muscle, Smooth, Vascular; Patch-Clamp Techniques; Pinacidil; Potassium Channel Blockers; Potassium Channels; Pyridines; Radioligand Assay; Rats; Vasodilator Agents | 1997 |
The effects of levcromakalim and pinacidil on the human internal mammary artery.
Topics: 4-Aminopyridine; Adenosine Triphosphate; Apamin; Charybdotoxin; Coronary Artery Bypass; Coronary Disease; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Guanidines; Humans; In Vitro Techniques; Male; Mammary Arteries; Muscle Relaxation; Muscle, Smooth, Vascular; Pinacidil; Potassium Channels; Tetraethylammonium; Vasodilation; Vasodilator Agents | 1997 |
Temperature-sensitive effects of potassium channel openers on isolated guinea pig myocardium and aorta.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Aorta, Thoracic; Cromakalim; Dose-Response Relationship, Drug; Endothelium, Vascular; Glyburide; Guanidines; Guinea Pigs; Heart Ventricles; In Vitro Techniques; Muscle, Smooth, Vascular; Myocardium; Norepinephrine; Oxadiazoles; Patch-Clamp Techniques; Pinacidil; Piperidines; Potassium Channels; Temperature; Vasodilator Agents | 1998 |
KATP channels are not essential for pressure-dependent control of renin secretion.
Topics: Adenosine Triphosphate; Animals; Arterioles; Calcium; Cromakalim; Glyburide; In Vitro Techniques; Juxtaglomerular Apparatus; Kidney; Male; Perfusion; Potassium Channels; Pressoreceptors; Pressure; Rats; Rats, Sprague-Dawley; Renal Circulation; Renin; Vasodilation | 1998 |
Protective effects against hydrogen peroxide-induced toxicity by activators of the ATP-sensitive potassium channel in isolated rat hearts.
Topics: Adenosine Triphosphate; Animals; Cromakalim; Free Radicals; Glyburide; Glycogen; Heart; Hydrogen Peroxide; In Vitro Techniques; Male; Myocardium; Oxidative Stress; Phosphocreatine; Potassium Channel Blockers; Potassium Channels; Purines; Rats; Rats, Sprague-Dawley; Vasodilator Agents; Ventricular Pressure; Xanthine Oxidase | 1998 |
Cardioprotective effects of KR-30450, a novel K+(ATP) opener, and its major metabolite KR-30818 on isolated rat hearts.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Heart; Heart Rate; Hypoglycemic Agents; In Vitro Techniques; L-Lactate Dehydrogenase; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Potassium Channel Blockers; Potassium Channels; Pyrimidines; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Vasodilator Agents | 1998 |
Enhancement of the vasodepressor response to adenosine by nicorandil in rats: comparison with cromakalim.
Topics: Adenosine; Adenosine Triphosphate; Animals; Blood Pressure; Cromakalim; Drug Synergism; Glyburide; Heart Rate; Male; Niacinamide; Nicorandil; Potassium Channels; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1998 |
Role of K+ channel opening and stimulation of cyclic GMP in the vasorelaxant effects of nicorandil in isolated piglet pulmonary and mesenteric arteries: relative efficacy and interactions between both pathways.
Topics: Animals; Cromakalim; Cyclic GMP; Enzyme Activation; Enzyme Inhibitors; Glyburide; Guanylate Cyclase; In Vitro Techniques; Male; Mesenteric Arteries; Niacinamide; Nicorandil; Nitroprusside; Potassium Channels; Pulmonary Artery; Swine; Vasodilator Agents; Verapamil | 1998 |
Possible involvement of K(ATP) channel activation in depressor responses to vasoactive neuropeptides in rats.
Topics: Acetylcholine; Animals; ATP-Binding Cassette Transporters; Blood Pressure; Calcitonin Gene-Related Peptide; Cromakalim; Glyburide; Heart Rate; KATP Channels; Male; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Sprague-Dawley; Substance P; Vasoactive Intestinal Peptide | 1998 |
Influence of potassium channel modulators on cognitive processes in mice.
Topics: Amnesia; Animals; Apamin; Avoidance Learning; Charybdotoxin; Cromakalim; Glyburide; Guanidines; Injections, Intraventricular; Male; Mice; Minoxidil; Pinacidil; Potassium Channels; Sulfonylurea Compounds; Tetraethylammonium | 1998 |
Characterization of K(ATP) channels in intact mammalian skeletal muscle fibres.
Topics: Animals; Cromakalim; Glyburide; In Vitro Techniques; Muscle Fibers, Skeletal; Muscle, Skeletal; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats | 1998 |
Potentiating effect of nicorandil on the adenosine A2 receptor-mediated vasodepression in rats: potential role for KATP channels.
Topics: Adenosine; Animals; Antihypertensive Agents; Blood Pressure; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Heart Rate; Injections, Intravenous; Male; Niacinamide; Nicorandil; Potassium Channels; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Theobromine; Vasodilator Agents | 1998 |
Synergistic effect of calcitonin gene-related peptide on adenosine-induced vasodepression in rats.
Topics: Adenosine; Animals; Blood Pressure; Calcitonin Gene-Related Peptide; Cromakalim; Drug Interactions; Glyburide; Male; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1998 |
Sulfonylureas inhibit cytokine-induced eosinophil survival and activation.
Topics: ATP-Binding Cassette Transporters; Calcium Channel Agonists; Calcium Channel Blockers; Cell Separation; Cell Survival; Cromakalim; Cytokines; Dexamethasone; Drug Synergism; Eosinophils; Glyburide; Growth Inhibitors; Humans; Immunosuppressive Agents; Lidocaine; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Compounds; Sulfonylurea Receptors; Superoxides; Tetraethylammonium | 1998 |
The effects of nifedipine and other calcium antagonists on the glibenclamide-sensitive K+ currents in smooth muscle cells from pig urethra.
Topics: Animals; Barium; Calcium Channel Blockers; Cromakalim; Female; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Muscle, Smooth; Nifedipine; Patch-Clamp Techniques; Potassium Channels; Swine; Urethra | 1998 |
Differential sensitivity to ATP-sensitive potassium channel openers of norepinephrine-induced contraction of guinea pig and rat aorta.
Topics: Adenosine Triphosphate; Animals; Aorta, Thoracic; Cromakalim; Diltiazem; Dose-Response Relationship, Drug; Female; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Oxadiazoles; Piperidines; Potassium Channels; Rats; Rats, Wistar; Vasoconstrictor Agents; Vasodilation | 1998 |
Calcium-dependent and ATP-sensitive potassium channels and the 'permissive' function of cyclic GMP in hypercapnia-induced pial arteriolar relaxation.
Topics: Adenosine Triphosphate; Animals; Benzimidazoles; Blood Pressure; Calcium; Carbon Dioxide; Cerebral Arteries; Cromakalim; Cyclic GMP; Glyburide; Hydrogen-Ion Concentration; Hypercapnia; Indazoles; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Penicillamine; Peptides; Pia Mater; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; Substrate Specificity; Vasodilation | 1998 |
Effects of ATP-sensitive potassium channel regulators on chloride channels in the sarcoplasmic reticulum vesicles from rabbit skeletal muscle.
Topics: Adenosine Triphosphate; Animals; Chloride Channels; Cromakalim; Glyburide; Ion Channel Gating; Minoxidil; Muscle, Skeletal; Potassium Channels; Rabbits; Sarcoplasmic Reticulum | 1998 |
Basal nitric oxide release differentially modulates vasodilations by pinacidil and levcromakalim in goat coronary artery.
Topics: Animals; Coronary Vessels; Cromakalim; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Goats; Guanidines; Hypoglycemic Agents; In Vitro Techniques; Methylene Blue; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Papaverine; Pinacidil; Potassium Channels; Vasodilation; Vasodilator Agents | 1998 |
Oxidant stress with hydrogen peroxide attenuates calcium paradox injury: role of protein kinase C and ATP-sensitive potassium channel.
Topics: Adenosine Triphosphate; Alkaloids; Animals; Anti-Arrhythmia Agents; Benzophenanthridines; Calcium; Cromakalim; Enzyme Inhibitors; Glyburide; Hemodynamics; Hydrogen Peroxide; L-Lactate Dehydrogenase; Male; Myocardial Ischemia; Myocardium; Perfusion; Phenanthridines; Potassium Channel Blockers; Potassium Channels; Protein Kinase C; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate | 1998 |
Levcromakalim decreases vascular tone, cytoplasmic Ca2+ and Ca2+ sensitivity in canine basilar artery.
Topics: Animals; Basilar Artery; Calcium; Calcium Channel Blockers; Cromakalim; Cytoplasm; Dogs; Dose-Response Relationship, Drug; Female; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nicardipine; Peptides; Potassium Channel Blockers; Potassium Channels; Serotonin; Tetraethylammonium; Vasoconstriction | 1998 |
Relationship among NO, the KATP channel, and opioids in hypoxic pial artery dilation.
Topics: Adenosine Triphosphate; Animals; Arteries; Blood Pressure; Calcitonin Gene-Related Peptide; Cromakalim; Cyclic GMP; Female; Glyburide; Hypoxia; Male; Nitric Oxide; Opioid Peptides; Pia Mater; Potassium Channels; Swine; Vasodilation; Vasodilator Agents | 1998 |
Preconditioning with cromakalim improves long-term myocardial preservation for heart transplantation.
Topics: Adenine Nucleotides; Adenosine; Allopurinol; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Coronary Circulation; Creatinine; Cromakalim; Glutathione; Glyburide; Heart; Heart Transplantation; Hemodynamics; Insulin; L-Lactate Dehydrogenase; Magnesium; Organ Preservation; Organ Preservation Solutions; Potassium Channels; Potassium Chloride; Rabbits; Raffinose; Sodium Chloride | 1998 |
Basal activation of ATP-sensitive potassium channels in murine colonic smooth muscle cell.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Colon; Cromakalim; Female; Glyburide; In Vitro Techniques; Ion Channel Gating; Male; Membrane Potentials; Mice; Mice, Inbred BALB C; Muscle, Smooth; Patch-Clamp Techniques; Potassium Channels; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription, Genetic | 1998 |
Potassium channel openers inhibit ATP-induced cytosolic free calcium increase in cultured rabbit aortic smooth muscle cells.
Topics: Adenosine Triphosphate; Animals; Aorta, Thoracic; Calcium; Cells, Cultured; Cromakalim; Glyburide; Muscle, Smooth, Vascular; Nicorandil; Pinacidil; Potassium Channels; Rabbits | 1996 |
A K+ single channel and whole-cell clamp study on the effects of levocromakalim in guinea pig portal vein cells.
Topics: Animals; Calcium; Cromakalim; Drug Interactions; Glyburide; Guinea Pigs; Hypoglycemic Agents; Muscle, Smooth, Vascular; Patch-Clamp Techniques; Peptides; Portal Vein; Potassium Channels; Vasodilator Agents | 1998 |
ATP-sensitive K+ current and its modulation by substance P in gastric myocytes isolated from guinea pig.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Barium; Cesium; Cromakalim; Female; Glyburide; Guinea Pigs; Hypoglycemic Agents; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Patch-Clamp Techniques; Potassium; Potassium Channels; Pyloric Antrum; Substance P; Tetraethylammonium; Vasodilator Agents | 1998 |
Reconstituted human cardiac KATP channels: functional identity with the native channels from the sarcolemma of human ventricular cells.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adolescent; Adult; Animals; ATP-Binding Cassette Transporters; Child; CHO Cells; Cloning, Molecular; COS Cells; Cricetinae; Cromakalim; Diazoxide; DNA, Complementary; Gene Library; Glyburide; Heart Ventricles; Humans; Magnesium; Middle Aged; Myocardium; Patch-Clamp Techniques; Pinacidil; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Receptors, Drug; Sarcolemma; Sulfonylurea Receptors; Tolbutamide; Transfection | 1998 |
Cellular mechanisms by which adenosine induces vasodilatation in rat skeletal muscle: significance for systemic hypoxia.
Topics: Adenosine; Animals; Antihypertensive Agents; Blood Pressure; Cromakalim; Enzyme Inhibitors; Femoral Artery; Glyburide; Heart Rate; Hypoglycemic Agents; Hypoxia; Male; Muscle, Skeletal; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitroprusside; Phenethylamines; Potassium Channel Blockers; Potassium Channels; Purinergic P1 Receptor Agonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Regional Blood Flow; Vasodilator Agents | 1999 |
Effect of age on the vasorelaxation elicited by cromakalim. Role of K+ channels and cyclic GMP.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Aging; Animals; Aorta, Thoracic; Cromakalim; Cyclic GMP; Endothelium, Vascular; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Male; Muscle Contraction; Potassium Channels; Rabbits; Vasodilation; Vasodilator Agents | 1998 |
Endothelium-dependent blunted membrane potential responses to ATP-sensitive K+ channel modulators in aortae from rats with cirrhosis.
Topics: Adenosine Triphosphate; Animals; Aorta; Bosentan; Cromakalim; Diazoxide; Endothelin-1; Endothelium, Vascular; Glyburide; Liver Cirrhosis, Experimental; Male; Membrane Potentials; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; Sulfonamides; Tolbutamide | 1999 |
Comparison of the vascular relaxant effects of ATP-dependent K+ channel openers on aorta and pulmonary artery isolated from spontaneously hypertensive and Wistar-Kyoto rats.
Topics: Adenosine Triphosphate; Aminoquinolines; Animals; Aorta, Thoracic; Apamin; Benzopyrans; Charybdotoxin; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Hypertension; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nicorandil; Nitroprusside; Norepinephrine; Picolines; Pinacidil; Potassium; Potassium Channels; Pulmonary Artery; Pyrans; Pyrrolidinones; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasodilator Agents | 1999 |
Glibenclamide-sensitive K+ channels underlying levcromakalim-induced relaxation in pig urethra.
Topics: Animals; Cromakalim; Dose-Response Relationship, Drug; Female; Glyburide; In Vitro Techniques; Membrane Potentials; Muscle Relaxation; Patch-Clamp Techniques; Potassium Channels; Swine; Time Factors; Urethra | 1999 |
KATP channel modulators and myocardial damages induced by ischemia-reperfusion: membrane lipids injury and arrhythmias.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Cromakalim; Electrophysiology; Fatty Acids, Nonesterified; Glyburide; Guinea Pigs; In Vitro Techniques; Membrane Lipids; Myocardial Reperfusion Injury; Myocardium; Potassium Channel Blockers; Potassium Channels; Vasodilator Agents | 1998 |
Mechanisms of adrenomedullin-induced increase of pulmonary blood flow in fetal sheep.
Topics: Adrenomedullin; Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Cromakalim; Cyclooxygenase Inhibitors; Female; Fetus; Glyburide; Indomethacin; Lung; Muscle, Smooth, Vascular; Nitroarginine; Peptide Fragments; Peptides; Potassium Channel Blockers; Pregnancy; Pulmonary Artery; Pulmonary Circulation; Regional Blood Flow; Sheep; Vasodilator Agents | 1999 |
Relevance of inter- and intraventricular electrical dispersion to arrhythmogenesis in normal and ischaemic rabbit myocardium: a study with cromakalim, 5-hydroxydecanoate and glibenclamide.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Disease; Cromakalim; Decanoic Acids; Glyburide; Heart; Hydroxy Acids; In Vitro Techniques; Male; Myocardial Ischemia; Potassium Channels; Rabbits; Refractory Period, Electrophysiological; Ventricular Fibrillation | 1999 |
Differential effects of pinacidil, cromakalim, and NS 1619 on electrically evoked contractions in rat vas deferens.
Topics: Animals; Benzimidazoles; Charybdotoxin; Cromakalim; Electric Stimulation; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Pinacidil; Potassium Channels; Rats; Rats, Sprague-Dawley; Vas Deferens; Vasodilator Agents | 1997 |
Role of K+ channels in A2A adenosine receptor-mediated dilation of the pressurized renal arcuate artery.
Topics: 4-Aminopyridine; Adenosine; Amifampridine; Animals; Antihypertensive Agents; Apamin; Arteries; Barium; Cromakalim; Enzyme Inhibitors; Glyburide; In Vitro Techniques; Kidney; Male; Nicardipine; Ouabain; Peptides; Phenethylamines; Potassium; Potassium Channels; Pressure; Purinergic P1 Receptor Agonists; Rabbits; Receptor, Adenosine A2A; Receptors, Purinergic P1; Vasodilation; Vasodilator Agents | 1999 |
The ginsenoside Rg3 evokes endothelium-independent relaxation in rat aortic rings: role of K+ channels.
Topics: Animals; Antineoplastic Agents, Phytogenic; Aorta, Thoracic; Calcium; Calcium Channel Blockers; Cromakalim; Dose-Response Relationship, Drug; Endothelium, Vascular; Ginsenosides; Glyburide; In Vitro Techniques; Male; Muscle Relaxation; Nifedipine; Potassium Channel Blockers; Potassium Channels; Potassium Chloride; Rats; Rats, Sprague-Dawley; Rubidium Radioisotopes; Saponins; Tetraethylammonium; Vasodilator Agents | 1999 |
ATP-sensitive potassium channels regulate in vivo dopamine release in rat striatum.
Topics: Adenosine Triphosphate; Animals; Consciousness; Cromakalim; Dextroamphetamine; Diazoxide; Dopamine; Dopamine Uptake Inhibitors; Glyburide; Hypoglycemic Agents; Injections, Subcutaneous; Male; Microdialysis; Movement; Neostriatum; Potassium Channels; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1999 |
Effects of nicorandil as compared to mixtures of sodium nitroprusside and levcromakalim in isolated rat aorta.
Topics: Animals; Aorta; Cromakalim; Cyclic GMP; Glyburide; In Vitro Techniques; Male; Nicorandil; Nitroprusside; Norepinephrine; Potassium Chloride; Rats; Rats, Wistar; Vasoconstriction; Vasodilator Agents | 1999 |
Inhibition of Na(+)-K+ pump alleviates the shortening of action potential duration caused by metabolic inhibition via blockade of KATP channels in coronary perfused ventricular muscles of guinea-pigs.
Topics: Action Potentials; Animals; Cells, Cultured; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Guinea Pigs; Models, Biological; Muscle, Smooth, Vascular; Ouabain; Patch-Clamp Techniques; Perfusion; Potassium Channels; Sodium-Potassium-Exchanging ATPase; Time Factors; Vasodilator Agents; Ventricular Function | 1999 |
Differential effects of lidocaine and mexiletine on relaxations to ATP-sensitive K+ channel openers in rat aortas.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Aorta; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Lidocaine; Male; Mexiletine; Potassium Channels; Rats; Rats, Inbred WKY; Vasodilation | 1999 |
Inhibitory effect of 4-aminopyridine on responses of the basilar artery to nitric oxide.
Topics: 4-Aminopyridine; Acetylcholine; Adenosine Triphosphate; Animals; Basilar Artery; Cromakalim; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glyburide; Guanylate Cyclase; Male; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Papaverine; Potassium Channel Blockers; Quinoxalines; Rats; Rats, Sprague-Dawley; Vasodilation; Vasodilator Agents | 1999 |
Pharmacological evidence for a KATP channel in renin-secreting cells from rat kidney.
Topics: Angiotensin II; Animals; Arterioles; Barbiturates; Calcium; Cromakalim; Cytoplasm; Egtazic Acid; Fluorescent Dyes; Fura-2; Furosemide; Glyburide; Isoxazoles; Kidney Cortex; Kidney Glomerulus; Kinetics; Membrane Potentials; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; Renal Circulation; Renin; Time Factors | 1999 |
Comparative studies on the relaxing action of several adenosine 5'-triphosphate-sensitive K+ channel openers in pig urethra.
Topics: Adenosine Triphosphate; Animals; Cromakalim; Female; Glyburide; In Vitro Techniques; Potassium Channels; Reproducibility of Results; Swine; Urethra; Vasodilator Agents | 1999 |
Cyclic GMP regulates cromakalim-induced relaxation in the rat aortic smooth muscle: role of cyclic GMP in K(ATP)-channels.
Topics: Adenosine Triphosphate; Animals; Aorta, Thoracic; Apamin; Calcium; Charybdotoxin; Cromakalim; Cyclic GMP; Endothelium, Vascular; Glyburide; In Vitro Techniques; Male; Methylene Blue; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroprusside; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Inbred WKY | 1999 |
Potentiation of quantal catecholamine secretion by glibenclamide: evidence for a novel role of sulphonylurea receptors in regulating the Ca(2+) sensitivity of exocytosis.
Topics: Animals; ATP-Binding Cassette Transporters; Caffeine; Calcium; Catecholamines; Cromakalim; Egtazic Acid; Electrochemistry; Exocytosis; Glyburide; Kinetics; Membrane Potentials; Patch-Clamp Techniques; PC12 Cells; Pinacidil; Potassium; Potassium Channels; Potassium Channels, Inwardly Rectifying; Quantum Theory; Rats; Receptors, Drug; Sulfonylurea Receptors; Tolbutamide | 1999 |
Protective effect of cromakalim and diazoxide, and proulcerogenic effect of glibenclamide on indomethacin-induced gastric injury.
Topics: Animals; Arteries; Blood Glucose; Blood Pressure; Cromakalim; Diazoxide; Dose-Response Relationship, Drug; Gastric Mucosa; Gastrointestinal Agents; Glyburide; Hypoglycemic Agents; Indomethacin; Male; Neutrophils; Peroxidase; Rats; Regional Blood Flow; Stomach; Stomach Diseases; Vasodilation; Vasodilator Agents | 1999 |
Role of ATP-dependent K(+) channels in the electrical excitability of early embryonic stem cell-derived cardiomyocytes.
Topics: 2,4-Dinitrophenol; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Calcium Channel Agonists; Cardiotonic Agents; Cell Differentiation; Charybdotoxin; Cromakalim; Enzyme Inhibitors; Glyburide; Isoproterenol; KATP Channels; Membrane Potentials; Mice; Myocardial Contraction; Myocardium; Organoids; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Inwardly Rectifying; Stem Cells; Thapsigargin | 1999 |
Ischemic preconditioning mediated by activation of KATP channels in rat small intestine.
Topics: Adenosine Triphosphate; Animals; Blood Pressure; Cromakalim; Glyburide; Intestine, Small; Ischemic Preconditioning; L-Lactate Dehydrogenase; Male; Potassium Channels; Rats; Rats, Wistar; Reperfusion Injury | 1999 |
Involvement of ATP-sensitive potassium channels in a model of a delayed vascular hyporeactivity induced by lipopolysaccharide in rats.
Topics: Adenosine Triphosphate; Animals; Aorta, Thoracic; Blood Pressure; Cromakalim; Enzyme Inhibitors; Glyburide; Heart Rate; In Vitro Techniques; Lipopolysaccharides; Male; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Phenylephrine; Potassium Channels; Rats; Rats, Wistar; Tetraethylammonium; Vasodilator Agents | 1999 |
Effects of K+ channel modulators on the relationship between action potential duration and Ca2+ transients in single ventricular myocytes of the guinea pig.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium; Cromakalim; Glyburide; Guinea Pigs; Heart Ventricles; Hypoglycemic Agents; Male; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Pyridines; Time Factors; Vasodilator Agents; Ventricular Function | 1999 |
Roles of potassium channels and nitric oxide in modulation of uterine contractions in rat pregnancy.
Topics: Adenosine Triphosphate; Animals; Benzimidazoles; Cromakalim; Female; Gestational Age; Glyburide; In Vitro Techniques; Ion Channel Gating; Labor, Obstetric; Nitric Oxide; Potassium Channel Blockers; Potassium Channels; Pregnancy; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Tetraethylammonium; Uterine Contraction | 1999 |
Differential effects of pinacidil and levcromakalim on the contractions elicited electrically or by noradrenaline in the portal vein of the rabbit.
Topics: Adrenergic alpha-Antagonists; Animals; Apamin; Charybdotoxin; Cromakalim; Dose-Response Relationship, Drug; Electric Stimulation; Female; Glyburide; In Vitro Techniques; Male; Norepinephrine; Pinacidil; Portal Vein; Potassium Channels; Rabbits; Tetrodotoxin; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents | 1999 |
A novel K(ATP) current in cultured neonatal rat atrial appendage cardiomyocytes.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Atrial Appendage; Cells, Cultured; Cromakalim; Diazoxide; Electric Conductivity; Glyburide; Hypotonic Solutions; Physical Stimulation; Potassium Channels; Protein Isoforms; Rats | 1999 |
Modulation of norepinephrine release by ATP-dependent K(+)-channel activators and inhibitors in guinea-pig and human isolated right atrium.
Topics: Adenosine; Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-2 Receptor Agonists; Analysis of Variance; Animals; Clonidine; Cromakalim; Decanoic Acids; Diazoxide; Dose-Response Relationship, Drug; Glyburide; Guinea Pigs; Heart Atria; Humans; Hydroxy Acids; In Vitro Techniques; Male; Muscarinic Agonists; Norepinephrine; Oxotremorine; Pinacidil; Potassium Channel Blockers; Potassium Channels; Stimulation, Chemical; Sympathetic Nervous System | 1999 |
The effects of ZD6169 on the ATP-dependent K(+) current (I(K)(ATP)) in isolated cat ventricular myocytes.
Topics: Action Potentials; Amides; Animals; Antihypertensive Agents; ATP-Binding Cassette Transporters; Benzophenones; Cats; Cell Separation; Cromakalim; Glyburide; Heart Ventricles; Hypoglycemic Agents; In Vitro Techniques; KATP Channels; Myocardium; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Inwardly Rectifying | 1999 |
The effects of a newly synthesized ATP-sensitive potassium channel opener, MJ-355, on blood pressure and myocardial ischemia-reperfusion injury in rats.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Arrhythmias, Cardiac; ATP-Binding Cassette Transporters; Benzopyrans; Blood Pressure; Cromakalim; Glyburide; Hemodynamics; Hypertension; Hypoglycemic Agents; KATP Channels; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pyrrolidinones; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley | 1999 |
ATP-gated K(+) channel openers enhance opioid antinociception: indirect evidence for the release of endogenous opioid peptides.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenosine Triphosphate; Analgesics; Animals; Cromakalim; Diazoxide; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Glyburide; Injections, Intraventricular; Ion Channel Gating; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Opioid Peptides; Pain; Potassium Channels; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin | 1999 |
Electrophysiological actions of a novel K(+) channel opener MCC-134 on rabbit portal vein smooth muscle.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Apamin; Calcium; Charybdotoxin; Cromakalim; Dose-Response Relationship, Drug; Electrophysiology; Female; Glyburide; Imidazoles; Inosine Diphosphate; Male; Membrane Potentials; Muscle, Smooth, Vascular; Norepinephrine; Patch-Clamp Techniques; Peptides; Portal Vein; Potassium Channels; Rabbits; Thioamides; Uridine Diphosphate; Vasodilator Agents | 1999 |
Effects of potassium channel modulators on myotropic responses of aortic rings of pregnant rats.
Topics: Animals; Aorta; Benzimidazoles; Cromakalim; Female; Glyburide; In Vitro Techniques; Muscle, Smooth, Vascular; Peptides; Potassium Channel Blockers; Potassium Channels; Pregnancy; Pregnancy, Animal; Rats; Rats, Sprague-Dawley; Reference Values; Tetraethylammonium; Vasoconstrictor Agents; Vasodilator Agents | 2000 |
The role of endothelium-derived nitric oxide in relaxations to levcromakalim in the rat aorta.
Topics: Animals; Aorta, Thoracic; ATP-Binding Cassette Transporters; Benzoates; Cromakalim; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Guanylate Cyclase; Hydrazines; Imidazoles; KATP Channels; Male; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroarginine; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Inbred WKY; Vasodilator Agents | 1999 |
Identification and properties of ATP-sensitive potassium channels in myocytes from rabbit Purkinje fibres.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Cell Separation; Computer Simulation; Cromakalim; Deoxyglucose; Dose-Response Relationship, Drug; Glyburide; Heart Ventricles; Ion Channel Gating; Male; Patch-Clamp Techniques; Potassium Channels; Purkinje Fibers; Rabbits; Sodium Cyanide | 1999 |
KRN2391: dual action on rat pulmonary artery and no loss of potency in pulmonary hypertension.
Topics: Adenosine Triphosphate; Animals; Cromakalim; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glyburide; Guanylate Cyclase; Humans; Hypertension, Pulmonary; Hypoglycemic Agents; In Vitro Techniques; Infant, Newborn; Male; Methylene Blue; Molsidomine; Nitric Oxide Donors; Potassium Channels; Pulmonary Artery; Pyridines; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents | 2000 |
Antinociceptive action of epidural K+(ATP) channel openers via interaction with morphine and an alpha(2)- adrenergic agonist in rats.
Topics: Adenosine Triphosphate; Adrenergic alpha-Agonists; Analgesia; Analgesics, Opioid; Anesthetics, Combined; Animals; Cromakalim; Dexmedetomidine; Drug Interactions; Drug Synergism; Glyburide; Injections, Epidural; Ion Channel Gating; Male; Morphine; Naloxone; Narcotic Antagonists; Nicorandil; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley | 2000 |
Properties and pharmacological modification of ATP-sensitive K(+) channels in cat tracheal myocytes.
Topics: Adenosine Diphosphate; Animals; ATP-Binding Cassette Transporters; Cats; Cromakalim; Electrophysiology; Female; Glyburide; Guanosine Diphosphate; In Vitro Techniques; KATP Channels; Male; Membrane Potentials; Muscle, Smooth; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Inwardly Rectifying; Uridine Diphosphate | 2000 |
Hyperpolarisation of rat mesenteric endothelial cells by ATP-sensitive K(+) channel openers.
Topics: Adenosine Triphosphate; Animals; Apamin; Barium Compounds; Benzimidazoles; Carbachol; Charybdotoxin; Chlorides; Cromakalim; Dose-Response Relationship, Drug; Electrophysiology; Endothelium, Vascular; Glyburide; Glycyrrhetinic Acid; In Vitro Techniques; Male; Membrane Potentials; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Ouabain; Potassium Channels; Rats; Rats, Wistar; Vasodilator Agents | 2000 |
Block of cardiac ATP-sensitive K(+) channels reduces hydroxyl radicals in the rat myocardium.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Cromakalim; Decanoic Acids; Dose-Response Relationship, Drug; Ferrous Compounds; Glyburide; Hydroxy Acids; Hydroxybenzoates; Hydroxyl Radical; Hypoglycemic Agents; Inhibitory Concentration 50; Iron Chelating Agents; Male; Microdialysis; Myocardial Ischemia; Myocardium; Nicorandil; Potassium Channel Blockers; Rats; Rats, Wistar; Salicylates; Time Factors | 2000 |
KATP channels regulate mitogenically induced proliferation in primary rat hepatocytes and human liver cell lines. Implications for liver growth control and potential therapeutic targeting.
Topics: Animals; ATP-Binding Cassette Transporters; Calcium; Cell Division; Cells, Cultured; Cromakalim; DNA Replication; Electrophysiology; Glyburide; Humans; KATP Channels; Kinetics; Liver; Minoxidil; Mitogens; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Quinidine; Rats; Reverse Transcriptase Polymerase Chain Reaction | 2000 |
Norepinephrine modulates single hypothalamic arcuate neurons via alpha(1)and beta adrenergic receptors.
Topics: Action Potentials; Animals; Arcuate Nucleus of Hypothalamus; Calcium; Cromakalim; Female; Glyburide; In Vitro Techniques; Locus Coeruleus; Magnesium; Male; Morphine; Naloxone; Neural Inhibition; Neural Pathways; Neurons; Norepinephrine; Phentolamine; Prazosin; Propranolol; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, beta; Yohimbine | 2000 |
Interaction of cyclic AMP modulating agents with levcromakalim in the relaxation of rat isolated mesenteric artery.
Topics: Adenosine-5'-(N-ethylcarboxamide); Animals; Bucladesine; Colforsin; Cromakalim; Cyclic AMP; Dose-Response Relationship, Drug; Drug Interactions; Glyburide; In Vitro Techniques; Male; Mesenteric Arteries; Methoxamine; Rats; Rats, Wistar; Thionucleotides; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2000 |
K(+) channel inhibition, calcium signaling, and vasomotor tone in canine pulmonary artery smooth muscle.
Topics: 4-Aminopyridine; Adrenergic alpha-Agonists; Animals; Calcium Signaling; Cells, Cultured; Cromakalim; Dogs; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glyburide; In Vitro Techniques; Membrane Potentials; Muscle, Smooth, Vascular; Phenylephrine; Potassium Channel Blockers; Potassium Channels; Pulmonary Artery; Thapsigargin; Vasoconstriction; Vasodilator Agents; Vasomotor System | 2000 |
The identification of a potent imidazoline-based vascular K(ATP) channel antagonist.
Topics: Animals; Anti-Arrhythmia Agents; ATP-Binding Cassette Transporters; Cattle; Clonidine; Coronary Vessels; Cromakalim; Glyburide; Guanidines; Heart Atria; Heart Rate; Hypoglycemic Agents; Imidazoles; In Vitro Techniques; KATP Channels; Muscle, Smooth, Vascular; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pyridines; Radioligand Assay; Rats; Swine; Vasodilator Agents | 2000 |
K(ATP) channel activation reduces the severity of postresuscitation myocardial dysfunction.
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Blood Pressure; Cardiac Complexes, Premature; Coronary Circulation; Cromakalim; Glyburide; Heart; Incidence; Ischemic Preconditioning, Myocardial; Perfusion; Potassium Channels; Rats; Rats, Sprague-Dawley; Resuscitation; Survival Analysis | 2000 |
Guanylate cyclase and not ATP-dependent K(+) channels seems temperature-dependent in smooth muscle relaxation of human umbilical arteries.
Topics: Adenosine Triphosphate; Arginine; Cromakalim; Dose-Response Relationship, Drug; Female; Glyburide; Guanylate Cyclase; Humans; In Vitro Techniques; Molsidomine; Muscle, Smooth, Vascular; Nicorandil; Nitroarginine; Oxadiazoles; Potassium Channels; Pregnancy; Quinoxalines; Serotonin; Temperature; Umbilical Arteries; Vasodilation; Vasodilator Agents | 2000 |
The effects of caffeine on ATP-sensitive K(+) channels in smooth muscle cells from pig urethra.
Topics: 1-Methyl-3-isobutylxanthine; Animals; ATP-Binding Cassette Transporters; Caffeine; Central Nervous System Stimulants; Cromakalim; Drug Interactions; Egtazic Acid; Glyburide; KATP Channels; Membrane Potentials; Muscle, Smooth; Potassium Channels; Potassium Channels, Inwardly Rectifying; Ryanodine; Swine; Urethra; Uridine Diphosphate | 2000 |
Calcium modulation of vascular smooth muscle ATP-sensitive K(+) channels: role of protein phosphatase-2B.
Topics: Adenosine Triphosphate; Animals; Calcineurin; Calcineurin Inhibitors; Calcium; Cells, Cultured; Cromakalim; Enzyme Inhibitors; Glyburide; Male; Membrane Potentials; Muscle, Smooth, Vascular; Patch-Clamp Techniques; Potassium; Potassium Channels; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 2000 |
Intrahippocampal infusions of k-atp channel modulators influence spontaneous alternation performance: relationships to acetylcholine release in the hippocampus.
Topics: Acetylcholine; Animals; Behavior, Animal; Cromakalim; Glucose; Glyburide; Hippocampus; Hypoglycemic Agents; Male; Maze Learning; Memory; Microdialysis; Potassium Channels; Rats; Rats, Sprague-Dawley | 2001 |
Effects of K+ channel openers on I K(ATP) of human atrial myocytes at physiological temperatures.
Topics: Adenosine Triphosphate; Adult; Aged; Cromakalim; Female; Glyburide; Heart Atria; Humans; Hypoglycemic Agents; Male; Middle Aged; Pinacidil; Potassium Channels; Temperature; Vasodilator Agents | 2001 |
The role of oxygen-derived free radicals in augmented relaxations to levcromakalim in the aorta from hypertensive rats.
Topics: Animals; Aorta; Blood Pressure; Catalase; Cromakalim; Deferoxamine; Dose-Response Relationship, Drug; Free Radical Scavengers; Glyburide; Hydrogen Peroxide; Hypertension; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Channels; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Superoxide Dismutase; Vasodilator Agents | 2001 |
The role of K+ATP channels in the control of pre- and post-ischemic left ventricular developed pressure in septic rat hearts.
Topics: Animals; ATP-Binding Cassette Transporters; Blood Pressure; Coronary Circulation; Cromakalim; Escherichia coli Infections; Glyburide; Hypoglycemic Agents; KATP Channels; Myocardial Contraction; Myocardial Ischemia; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Sprague-Dawley; Sepsis; Stroke Volume; Vasodilator Agents; Ventricular Function, Left | 2001 |
Low levels of K(ATP) channel activation decrease excitability and contractility of urinary bladder.
Topics: Action Potentials; Adenosine Diphosphate; Adenosine Triphosphate; Amides; Animals; Benzophenones; Cromakalim; Glyburide; Guanosine Triphosphate; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Potassium Channels; Urinary Bladder | 2001 |
Dual action of ZD6169, a novel K(+) channel opener, on ATP-sensitive K(+) channels in pig urethral myocytes.
Topics: Adenosine Triphosphate; Amides; Animals; Anti-Arrhythmia Agents; Benzophenones; Cells, Cultured; COS Cells; Cromakalim; Electric Conductivity; Female; Glyburide; Hypoglycemic Agents; Imidazoles; Ion Channel Gating; Membrane Potentials; Muscle, Smooth; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Inwardly Rectifying; Swine; Time Factors; Urethra; Vasodilator Agents | 2001 |
Pharmacologic characterization of BMS-191095, a mitochondrial K(ATP) opener with no peripheral vasodilator or cardiac action potential shortening activity.
Topics: Action Potentials; Animals; Benzopyrans; Cardiovascular Agents; Cromakalim; Decanoic Acids; Dose-Response Relationship, Drug; Glyburide; Guanidines; Guinea Pigs; Heart; Heart Conduction System; Hydroxy Acids; Imidazoles; In Vitro Techniques; Male; Mitochondria; Myocardial Ischemia; Myocardial Reperfusion; Papillary Muscles; Patch-Clamp Techniques; Potassium; Potassium Channels; Rats; Rats, Sprague-Dawley; Vasodilator Agents; Vasomotor System | 2001 |
K(ATP) channels predominantly regulate conduit vessel tone in normoxic cat pulmonary arteries in vivo.
Topics: Adamantane; Adenosine Triphosphate; Animals; Blood Pressure; Cats; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Morpholines; Potassium Channels; Pulmonary Artery; Vasoconstriction; Vasodilator Agents | 2001 |
Identification and properties of a novel intracellular (mitochondrial) ATP-sensitive potassium channel in brain.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Boron Compounds; Brain; Cromakalim; Decanoic Acids; Diazoxide; Fluorescent Dyes; Glyburide; Guanosine Triphosphate; Hydroxy Acids; Kinetics; Ligands; Liver; Membrane Proteins; Mitochondria; Mitochondria, Liver; Models, Biological; Myocardium; Oxygen Consumption; Potassium Channels; Proteolipids; Rats; Time Factors; Vasodilator Agents | 2001 |
Hemodynamic effects of levcromakalim in neonatal porcine pulmonary hypertension.
Topics: Animals; Animals, Newborn; Blood Pressure; Cromakalim; Disease Models, Animal; Glyburide; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Ion Channel Gating; Potassium Channels; Streptococcus agalactiae; Swine; Vascular Resistance; Vasodilator Agents | 2001 |
An ATP-sensitive K(+) conductance in dissociated neurones from adult rat intracardiac ganglia.
Topics: Adenosine Triphosphate; Animals; Boron Compounds; Cell Hypoxia; Cromakalim; Electric Conductivity; Fluorescent Dyes; Ganglia; Glyburide; Heart Conduction System; Neurons; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar | 2001 |
K(ATP) channel opening during ischemia: effects on myocardial noradrenaline release and ventricular arrhythmias.
Topics: Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Coronary Circulation; Cromakalim; Female; Glyburide; Heart; Heart Ventricles; Hypoglycemic Agents; In Vitro Techniques; Male; Myocardial Ischemia; Myocardium; Norepinephrine; Potassium; Potassium Channels; Rabbits; Time Factors; Vasodilator Agents | 2001 |
Further investigations into the endothelium-dependent hyperpolarizing effects of bradykinin and substance P in porcine coronary artery.
Topics: Animals; Bicarbonates; Biological Factors; Bradykinin; Buffers; Coronary Vessels; Cromakalim; Endothelium, Vascular; Epoprostenol; Glyburide; HEPES; In Vitro Techniques; Indomethacin; Isotonic Solutions; Membrane Potentials; Muscle, Smooth, Vascular; Nitric Oxide Donors; Nitroarginine; Peptides; Sodium Chloride; Substance P; Swine; Time Factors; Vasodilator Agents | 2001 |
A xanthine-based KMUP-1 with cyclic GMP enhancing and K(+) channels opening activities in rat aortic smooth muscle.
Topics: Acetylcholine; Adenylyl Cyclases; Animals; Aorta; Aorta, Thoracic; Blood Pressure; Cells, Cultured; Cromakalim; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Heart Rate; In Vitro Techniques; Methylene Blue; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroprusside; Oxadiazoles; Phosphoric Diester Hydrolases; Piperidines; Potassium Channels; Quinoxalines; Rats; Rats, Wistar; Solubility; Vasodilation; Vasodilator Agents; Xanthine; Xanthines | 2001 |
Influence of ATP-sensitive K+ channel modulation on the mechanical properties of diabetic myocardium.
Topics: Adenosine Triphosphate; Animals; Biomechanical Phenomena; Blood Glucose; Cromakalim; Depression, Chemical; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Glyburide; Male; Myocardial Contraction; Pinacidil; Potassium Channels; Rats; Rats, Wistar; Vasodilator Agents | 2001 |
Effects of different types of K+ channel modulators on the spontaneous myogenic contraction of guinea-pig urinary bladder smooth muscle.
Topics: 4-Aminopyridine; Animals; Anti-Arrhythmia Agents; Apamin; Barium; Benzimidazoles; Calcium Channel Blockers; Cation Transport Proteins; Cromakalim; Diltiazem; Ether-A-Go-Go Potassium Channels; Female; Glyburide; Guinea Pigs; Large-Conductance Calcium-Activated Potassium Channels; Male; Muscle Contraction; Muscle, Smooth; Nisoldipine; Parasympatholytics; Peptides; Periodicity; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Calcium-Activated; Potassium Channels, Voltage-Gated; Pyridines; Small-Conductance Calcium-Activated Potassium Channels; Urinary Bladder | 2001 |
The molecular composition of K(ATP) channels in human pulmonary artery smooth muscle cells and their modulation by growth.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Bronchodilator Agents; Cell Division; Cell Line; Cell Membrane; Cells, Cultured; Cromakalim; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Electrophysiology; Glyburide; Humans; Muscle, Smooth; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pulmonary Artery; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tissue Distribution; Transfection | 2002 |
Role of K(ATP) channels in the induction of ischemic tolerance by the 'adenosine mechanism' in neuronal cultures.
Topics: Adenosine; Animals; Brain Ischemia; Cells, Cultured; Cromakalim; Diglycerides; Glyburide; Neurons; Phenylisopropyladenosine; Potassium Channel Blockers; Potassium Channels; Protein Kinase C; Rats | 2000 |
Effects of cromakalim and glibenclamide on arteriolar and venular diameters and macromolecular leakage in the microcirculation during ischemia/reperfusion.
Topics: Adenosine Triphosphate; Animals; Arterioles; Capillary Permeability; Cheek; Cricetinae; Cromakalim; Dextrans; Fluorescein-5-isothiocyanate; Glyburide; Histamine; Ischemia; Lymphatic System; Male; Mesocricetus; Potassium Channel Blockers; Potassium Channels; Reperfusion Injury; Vasodilator Agents | 2002 |
Characterisation of the effects of potassium channel modulating agents on mouse intestinal smooth muscle.
Topics: Animals; Benzopyrans; Cromakalim; Cyclopentanes; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Glyburide; Guanidines; Ileum; Male; Mice; Muscle, Smooth; Pinacidil; Potassium Channel Blockers; Potassium Channels; Potassium Cyanide; Vasodilator Agents | 2002 |
Opening of mitochondrial ATP-sensitive potassium channels evokes oxygen radical generation in rabbit heart slices.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Cromakalim; Decanoic Acids; Dose-Response Relationship, Drug; Ferrous Compounds; Glyburide; Hydroxy Acids; Iron Chelating Agents; Linear Models; Malondialdehyde; Mitochondria, Heart; Myocardial Reperfusion; Myocardium; Pinacidil; Potassium Channels; Rabbits; Reaction Time; Reactive Oxygen Species | 2002 |
Effects of K(ATP) channel modulators on acetylcholine release from guinea-pig isolated atria and small intestine.
Topics: Acetylcholine; Animals; Atrial Function; Cromakalim; Diazoxide; Female; Glyburide; Guinea Pigs; Heart Atria; In Vitro Techniques; Intestine, Small; Male; Muscle, Smooth; Myenteric Plexus; Myocardial Contraction; Neuromuscular Junction; Pinacidil; Potassium Channel Blockers; Potassium Channels; Sulfonamides; Thiourea | 2002 |
Potassium channels and human corporeal smooth muscle cell tone: diabetes and relaxation of human corpus cavernosum smooth muscle by adenosine triphosphate sensitive potassium channel openers.
Topics: Adenosine Triphosphate; Cromakalim; Culture Techniques; Dose-Response Relationship, Drug; Erectile Dysfunction; Glyburide; Humans; Male; Muscle, Smooth, Vascular; Penile Erection; Penis; Phenylephrine; Pinacidil; Potassium Channels; Vasodilation; Vasodilator Agents | 2002 |
Effects of chronic treatment with cromakalim and glibenclamide in alloxan-induced diabetic rats.
Topics: Animals; Antihypertensive Agents; Blood Glucose; Blood Pressure; Cromakalim; Diabetes Mellitus, Experimental; Drug Interactions; Female; Glyburide; Heart Rate; Hypertension; Hypoglycemic Agents; Rats; Rats, Wistar | 2002 |
Active relaxation of human gallbladder muscle is mediated by ATP-sensitive potassium channels.
Topics: Adenosine Triphosphate; Animals; Carbachol; Cromakalim; Gallbladder; Glyburide; Guinea Pigs; Humans; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Potassium Channels; Sincalide | 2002 |
Differential effects of sulphonylureas on the vasodilatory response evoked by K(ATP) channel openers.
Topics: Adenosine Triphosphate; Animals; Aorta, Thoracic; Cricetinae; Cromakalim; Diazoxide; Drug Interactions; Gliclazide; Glyburide; Guinea Pigs; Hypoglycemic Agents; In Vitro Techniques; Ion Channel Gating; Male; Potassium Channels; Rats; Rats, Wistar; Species Specificity; Sulfonylurea Compounds; Vasodilation; Vasodilator Agents | 2003 |
Mexiletine differentially modulates vasorelaxation mediated by adenosine triphosphate-sensitive K+ channels in aortas from normotensive and hypertensive rats.
Topics: Animals; Anti-Arrhythmia Agents; Aorta, Thoracic; ATP-Binding Cassette Transporters; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Hypertension; Hypoglycemic Agents; KATP Channels; Male; Mexiletine; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide Donors; Nitroprusside; Phenylephrine; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2003 |
Defibrillatory action of glibenclamide is independent from ATP-sensitive K+ channels and free radicals.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Chromatography, High Pressure Liquid; Coronary Circulation; Cromakalim; Electric Stimulation; Glyburide; Heart Rate; Hydroxyl Radical; In Vitro Techniques; Male; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Superoxides; Vasodilator Agents; Ventricular Fibrillation | 2003 |
Effect of acute hypoxia on ATP-sensitive potassium currents in substantia gelatinosa neurons of juvenile rats.
Topics: Acute Disease; Adenosine Triphosphate; Age Factors; Animals; Anti-Arrhythmia Agents; Barium; Cesium; Cromakalim; Glyburide; Hypoxia; In Vitro Techniques; Membrane Potentials; Neurons; Parasympatholytics; Patch-Clamp Techniques; Potassium Channels; Rats; Substantia Gelatinosa | 2003 |
Shear stress increases expression of a KATP channel in rat and bovine pulmonary vascular endothelial cells.
Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Cattle; Cell Membrane; Cells, Cultured; Cromakalim; Cycloheximide; Electrophysiology; Endothelium, Vascular; Glyburide; HeLa Cells; Humans; Microcirculation; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pulmonary Circulation; Rats; Receptors, Drug; RNA, Messenger; Stress, Mechanical; Sulfonylurea Receptors | 2003 |
The role of K+ channels in vasorelaxation induced by hypoxia and the modulator effects of lidocaine in the rat carotid artery.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Carotid Artery, Common; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Hypoxia; In Vitro Techniques; Lidocaine; Male; Peptides; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Vasoconstriction; Vasodilation; Vasodilator Agents | 2003 |
Functional role of potassium channels in the vasodilating mechanism of levosimendan in porcine isolated coronary artery.
Topics: 4-Aminopyridine; Adenosine Triphosphate; Animals; Calcium; Coronary Vessels; Cromakalim; Glyburide; Hydrazones; In Vitro Techniques; Ion Channel Gating; Isometric Contraction; Muscle, Smooth, Vascular; Peptides; Potassium Channel Blockers; Potassium Channels; Pyridazines; Simendan; Swine; Tetraethylammonium; Vasodilator Agents | 2003 |
Cromakalim inhibits transmitter acetylcholine release in rat trachea by an action on epithelial cells and a diffusible factor.
Topics: Acetylcholine; Animals; Atropine; Cromakalim; Diffusion; Drug Interactions; Epithelial Cells; Epithelium; Female; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Male; Muscarinic Antagonists; Parasympathetic Nervous System; Rats; Rats, Sprague-Dawley; Trachea | 2003 |
Diazoxide induces delayed pre-conditioning in cultured rat cortical neurons.
Topics: Animals; Cell Death; Cell Hypoxia; Cell Survival; Cells, Cultured; Cerebral Cortex; Cromakalim; Decanoic Acids; Diazoxide; Enzyme Activation; Enzyme Inhibitors; Glucose; Glyburide; Hydroxy Acids; Ischemic Preconditioning; Mitochondria; Neurons; Neuroprotective Agents; Nicorandil; Nitro Compounds; Oxidative Stress; Propionates; Rats; Rats, Wistar; Succinate Dehydrogenase; Superoxides; Time Factors | 2003 |
ATP-dependent K+ channels in renal ischemia reperfusion injury.
Topics: Acute Kidney Injury; Adenosine Triphosphate; Animals; Cromakalim; Diazoxide; Disease Models, Animal; Glomerular Filtration Rate; Glyburide; Kidney; Kidney Function Tests; Male; Organ Culture Techniques; Potassium Channels; Probability; Rats; Rats, Sprague-Dawley; Reference Values; Reperfusion Injury; Sensitivity and Specificity | 2003 |
Spreading dilatation in rat mesenteric arteries associated with calcium-independent endothelial cell hyperpolarization.
Topics: Acetylcholine; Aniline Compounds; Animals; Barium; Calcium; Cromakalim; Endothelial Cells; Fluorescent Dyes; Glyburide; In Vitro Techniques; Male; Membrane Potentials; Mesenteric Arteries; Microscopy, Fluorescence; Myocytes, Smooth Muscle; NG-Nitroarginine Methyl Ester; Organic Chemicals; Patch-Clamp Techniques; Phenylephrine; Propidium; Rats; Rats, Wistar; Vasodilation; Xanthenes | 2004 |
Amplification by hyperoxia of coronary vasodilation induced by propofol.
Topics: Anesthetics, Intravenous; Animals; ATP-Binding Cassette Transporters; Blood Gas Analysis; Coronary Circulation; Coronary Vessels; Cromakalim; Electrolytes; Glyburide; Hyperoxia; In Vitro Techniques; KATP Channels; Myocardial Contraction; Myocardium; Oxygen; Perfusion; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Propofol; Rabbits; Vasodilation | 2004 |
Blocking actions of glibenclamide on ATP-sensitive K+ channels in pig urethral myocytes.
Topics: Action Potentials; Algorithms; Animals; ATP-Binding Cassette Transporters; Cromakalim; Dose-Response Relationship, Drug; Female; Glyburide; In Vitro Techniques; Ion Channel Gating; Myocytes, Smooth Muscle; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Receptors; Swine; Urethra | 2004 |
Role of ATP-sensitive K+ channels in relaxation of penile resistance arteries.
Topics: Adenosine Triphosphate; Animals; Arteries; Cromakalim; Erectile Dysfunction; Glyburide; Horses; Humans; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Penis; Piperazines; Potassium Channel Blockers; Potassium Channels; Prostaglandins E; Purines; Sildenafil Citrate; Sulfones; Vascular Resistance; Vasodilation; Vasodilator Agents | 2004 |
Visceral periadventitial adipose tissue regulates arterial tone of mesenteric arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 4-Aminopyridine; Adipose Tissue; Amifampridine; Animals; Apamin; Barium; Cromakalim; Delayed Rectifier Potassium Channels; Endothelin-1; Glyburide; Male; Mesenteric Artery, Superior; Peptides; Phenylephrine; Potassium; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Serotonin; Tetraethylammonium; Vascular Resistance; Vasodilation; Viscera | 2004 |
Role of adenosine triphosphate-dependent potassium channels in canine penile erection.
Topics: Adenosine Triphosphate; Animals; Arginine; Cromakalim; Dogs; Electric Stimulation; Glyburide; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Papaverine; Penile Erection; Potassium Channel Blockers; Potassium Channels; Pressure; Receptors, Drug | 2004 |
KATP-channel-induced vasodilation is modulated by the Na,K-pump activity in rabbit coronary small arteries.
Topics: Animals; Arteries; ATP-Binding Cassette Transporters; Cardiotonic Agents; Coronary Vessels; Cromakalim; Female; Glyburide; Hypoglycemic Agents; In Vitro Techniques; KATP Channels; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Ouabain; Patch-Clamp Techniques; Pinacidil; Potassium; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rabbits; Sodium-Potassium-Exchanging ATPase; Vasodilation; Vasodilator Agents | 2004 |
Altered vascular reactivity and KATP channel currents in vascular smooth muscle cells from deoxycorticosterone acetate (DOCA)-salt hypertensive rats.
Topics: Adenosine Triphosphate; Animals; Aorta, Thoracic; Blood Pressure; Canada; Cromakalim; Desoxycorticosterone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Implants; Electrophysiology; Endothelium, Vascular; Glyburide; Hypertension; Male; Membrane Potentials; Muscle, Smooth, Vascular; Nephrectomy; Phenylephrine; Potassium Channels; Potassium Chloride; Rats; Rats, Sprague-Dawley; Vasoconstriction; Vasodilation | 2004 |
Effect of two amino acids in TM17 of Sulfonylurea receptor SUR1 on the binding of ATP-sensitive K+ channel modulators.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; ATP-Binding Cassette Transporters; Binding Sites; Cell Line; Chromans; Cromakalim; Diazoxide; Glyburide; Humans; Kinetics; Models, Molecular; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Mutagenesis, Site-Directed; Oocytes; Potassium Channels, Inwardly Rectifying; Protein Conformation; Protein Structure, Secondary; Pyrrolidines; Rats; Receptors, Drug; Recombinant Proteins; Sulfonylurea Receptors; Transfection; Xenopus | 2004 |
Alteration of cyclopiazonic acid-mediated contracture of mouse diaphragm after denervation.
Topics: Action Potentials; Animals; Biological Assay; Boron Compounds; Caffeine; Cromakalim; Crotalid Venoms; Diaphragm; Electric Stimulation; Estrenes; Female; Glyburide; Indoles; Male; Membrane Potentials; Mice; Mice, Inbred ICR; Muscle Contraction; Muscle Denervation; Nicardipine; Phrenic Nerve; Pyrrolidinones; Sarcoplasmic Reticulum | 2005 |
Involvement of adenosine triphosphate-sensitive potassium channels in the response of membrane potential to hyperosmolality in cultured human aorta endothelial cells.
Topics: Aorta; ATP-Binding Cassette Transporters; Calibration; Cells, Cultured; Cromakalim; Diuretics, Osmotic; Endothelial Cells; Fluorescent Dyes; Glyburide; Humans; Hypoglycemic Agents; Indicators and Reagents; KATP Channels; Mannitol; Membrane Potentials; Osmolar Concentration; Perfusion; Potassium Channels; Potassium Channels, Inwardly Rectifying; Sodium Chloride; Sucrose; Thiobarbiturates; Vasodilator Agents | 2005 |
Role of KATP channels in the regulation of rat dura and pia artery diameter.
Topics: Animals; Arteries; Cromakalim; Dura Mater; Glyburide; Male; Pia Mater; Pinacidil; Potassium Channels; Rats; Rats, Sprague-Dawley; Vasodilation; Vasodilator Agents | 2005 |
Endogenous hydrogen peroxide regulates the excitability of midbrain dopamine neurons via ATP-sensitive potassium channels.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Cromakalim; Diazoxide; Dopamine; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Glutathione Peroxidase; Glyburide; Guinea Pigs; Hydrogen Peroxide; Hypoglycemic Agents; In Vitro Techniques; Isoquinolines; Membrane Potentials; Mesencephalon; Neurons; Organoplatinum Compounds; Patch-Clamp Techniques; Potassium Channels; Tetrodotoxin; Thiomalates; Time Factors; Vasodilator Agents | 2005 |
Antispasmodic and blood pressure lowering effects of Valeriana wallichii are mediated through K+ channel activation.
Topics: Animals; Cromakalim; Glyburide; Guinea Pigs; Hypoglycemic Agents; Ileum; In Vitro Techniques; Jejunum; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Parasympatholytics; Plant Extracts; Plant Roots; Potassium Channels; Rabbits; Rats; Rats, Sprague-Dawley; Valerian; Vascular Resistance | 2005 |
Evidence that inward rectifier K+ channels mediate relaxation by the PGI2 receptor agonist cicaprost via a cyclic AMP-independent mechanism.
Topics: Adenine; Adenylyl Cyclase Inhibitors; Animals; Apamin; Barium Compounds; Charybdotoxin; Chlorides; Cromakalim; Cyclic AMP; DDT; Dose-Response Relationship, Drug; Epoprostenol; Fluoxetine; Glyburide; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Neurotoxins; Phenylephrine; Potassium Channels, Inwardly Rectifying; Rats; Rats, Sprague-Dawley; Receptors, Epoprostenol; Vasodilator Agents | 2006 |
Role of ATP-sensitive K+ -channels in hemodynamic effects of peroxynitrite in anesthetized rats.
Topics: Adenosine Triphosphate; Anesthesia; Animals; Blood Pressure; Cromakalim; Cysteine; Dose-Response Relationship, Drug; Glyburide; Hemodynamics; Male; Peroxynitrous Acid; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; S-Nitrosothiols; Vascular Resistance | 2005 |
Multiple actions of U-37883A, an ATP-sensitive K+ channel blocker, on membrane currents in pig urethra.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adamantane; Adenosine Triphosphate; Analysis of Variance; Animals; Barium; Calcium Channel Agonists; Cromakalim; Dose-Response Relationship, Drug; Female; Glyburide; In Vitro Techniques; Membrane Potentials; Morpholines; Muscle Cells; Nitroprusside; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Swine; Time Factors; Urethra; Vasodilator Agents | 2005 |
Hybrid assemblies of ATP-sensitive K+ channels determine their muscle-type-dependent biophysical and pharmacological properties.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; ATP-Binding Cassette Transporters; Biophysics; Cromakalim; Diazoxide; DNA Primers; Dose-Response Relationship, Drug; Gene Expression Regulation; Glyburide; Hypoglycemic Agents; KATP Channels; Kinetics; Male; Models, Statistical; Muscle Fibers, Skeletal; Muscle, Skeletal; Muscles; Patch-Clamp Techniques; Phenotype; Potassium; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Wistar; Receptors, Drug; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; Sulfonylurea Receptors; Tolbutamide | 2006 |
Different glibenclamide-sensitivity of ATP-sensitive K+ currents using different patch-clamp recording methods.
Topics: Algorithms; Animals; ATP-Binding Cassette Transporters; Barium; Cell Extracts; Cromakalim; Dose-Response Relationship, Drug; Female; Flecainide; Glyburide; KATP Channels; Membrane Potentials; Myocytes, Smooth Muscle; Patch-Clamp Techniques; Potassium Channels, Inwardly Rectifying; Swine; Time Factors; Urethra | 2006 |
Effects of mitiglinide and sulfonylureas in isolated canine coronary arteries and perfused rat hearts.
Topics: Animals; Coronary Circulation; Coronary Vessels; Cromakalim; Dogs; Dose-Response Relationship, Drug; Glyburide; Heart; Hypoglycemic Agents; In Vitro Techniques; Indoles; Isoindoles; Male; Myocardial Reperfusion Injury; Perfusion; Rats; Rats, Wistar; Sulfonylurea Compounds; Time Factors; Vasodilation; Vasodilator Agents | 2006 |
The role of potassium channels in relaxant effect of levosimendan in rat small mesenteric arteries.
Topics: Animals; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Hydrazones; In Vitro Techniques; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; Potassium Channels, Inwardly Rectifying; Potassium Chloride; Pyridazines; Rats; Rats, Wistar; Simendan; Vasodilation; Vasodilator Agents | 2006 |
Investigation of the relaxant effects of pinacidil and cromakalim on the sheep sphincter of Oddi.
Topics: Animals; Cromakalim; Glyburide; In Vitro Techniques; Male; Muscle Relaxation; Parasympatholytics; Pinacidil; Potassium Channels; Sheep; Sphincter of Oddi | 2006 |
The role of potassium channels in the vasodilatory effect of levosimendan in human internal thoracic arteries.
Topics: Aged; Cardiotonic Agents; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Humans; Hydrazones; Mammary Arteries; Middle Aged; Phenylephrine; Phosphodiesterase Inhibitors; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Calcium-Activated; Pyridazines; Simendan; Tissue Culture Techniques; Vasodilation; Vasodilator Agents | 2006 |
Activation of the iberiotoxin-sensitive BKCa channels by salvianolic acid B of the porcine coronary artery smooth muscle cells.
Topics: Animals; Benzofurans; Coronary Vessels; Cromakalim; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Enzyme Activation; Enzyme Inhibitors; Glyburide; Guanylate Cyclase; In Vitro Techniques; Ion Channel Gating; Membrane Potentials; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Patch-Clamp Techniques; Peptides; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Calcium-Activated; Quinoxalines; Receptors, Drug; Salvia miltiorrhiza; Swine | 2006 |
Differential effects of etomidate and midazolam on vascular adenosine triphosphate-sensitive potassium channels: isometric tension and patch clamp studies.
Topics: Adenosine Triphosphate; Anesthetics, Intravenous; Animals; Aorta, Thoracic; ATP-Binding Cassette Transporters; Cells, Cultured; Cromakalim; Dose-Response Relationship, Drug; Electrophysiology; Etomidate; Glyburide; Isometric Contraction; Male; Midazolam; Myocytes, Smooth Muscle; Organ Culture Techniques; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Wistar; Receptors, Drug; Sulfonylurea Receptors; Transfection; Vasodilation; Vasodilator Agents | 2007 |
Alteration of vascular reactivity in diabetic human mammary artery and the effects of thiazolidinediones.
Topics: Aged; Cromakalim; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Therapy, Combination; Endothelium, Vascular; Female; Glyburide; Humans; Hypoglycemic Agents; Male; Mammary Arteries; Middle Aged; Nitroprusside; Phenylephrine; Pioglitazone; Potassium Channel Blockers; Potassium Chloride; Rosiglitazone; Thiazolidinediones; Vasoconstriction | 2006 |
Effect of KATP channel openers on myogenic and neurogenic responses in goat urinary bladder.
Topics: Acetylcholine; Animals; Atropine; Cholinergic Agents; Cromakalim; Dose-Response Relationship, Drug; Electric Stimulation; Female; Glyburide; Goats; In Vitro Techniques; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Pinacidil; Potassium Channel Blockers; Potassium Channels; Urinary Bladder | 2007 |
Inhibition of KATP channels in the rat tail artery by neurally released noradrenaline acting on postjunctional alpha2-adrenoceptors.
Topics: Adamantane; Adenosine Triphosphate; Animals; Arteries; Calcitonin Gene-Related Peptide; Cromakalim; Dose-Response Relationship, Drug; Electric Impedance; Excitatory Postsynaptic Potentials; Female; Glyburide; In Vitro Techniques; Ion Channel Gating; Morpholines; Muscle, Smooth, Vascular; Norepinephrine; Pinacidil; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Sympathetic Nervous System; Tail; Time Factors | 2007 |
Role of ATP-sensitive potassium channels in the biphasic effects of morphine on pentylenetetrazole-induced seizure threshold in mice.
Topics: Adenosine Triphosphate; Animals; Behavior, Animal; Blood Glucose; Cromakalim; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Glyburide; Hypoglycemic Agents; Male; Mice; Morphine; Narcotics; Pentylenetetrazole; Potassium Channels; Seizures; Severity of Illness Index | 2007 |
K+ channel modulation of slow wave activity in the guinea-pig prostate.
Topics: 4-Aminopyridine; Animals; Apamin; Benzopyrans; Calcitonin Gene-Related Peptide; Cromakalim; Cyclopentanes; Dose-Response Relationship, Drug; Electrophysiology; Glyburide; Guinea Pigs; In Vitro Techniques; Isoproterenol; Male; Membrane Potentials; Nitroprusside; Peptides; Potassium Channel Blockers; Potassium Channels; Prostate; Stromal Cells; Tetraethylammonium | 2007 |
Inhibitory effect of tramadol on vasorelaxation mediated by ATP-sensitive K+ channels in rat aorta.
Topics: Analgesics, Opioid; Animals; Aorta; Calcium Channel Blockers; Cromakalim; Data Interpretation, Statistical; Diltiazem; Dose-Response Relationship, Drug; Glyburide; Hypoglycemic Agents; In Vitro Techniques; KATP Channels; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Rats; Rats, Sprague-Dawley; Stereoisomerism; Tramadol | 2007 |
The endogenous cannabinoid anandamide inhibits cromakalim-activated K+ currents in follicle-enclosed Xenopus oocytes.
Topics: Animals; Arachidonic Acids; Calcium; Camphanes; Cromakalim; Egtazic Acid; Endocannabinoids; Female; Glyburide; KATP Channels; Oocytes; Pertussis Toxin; Piperidines; Polyunsaturated Alkamides; Potassium Channel Blockers; Pyrazoles; Rimonabant; Xenopus laevis | 2007 |
Role of different types of potassium channels in the antidepressant-like effect of agmatine in the mouse forced swimming test.
Topics: Agmatine; Animals; Antidepressive Agents; Apamin; Arginine; Charybdotoxin; Cromakalim; Dose-Response Relationship, Drug; Female; Glyburide; Injections, Intraventricular; Mice; Motor Activity; Nitric Oxide; Potassium Channel Blockers; Potassium Channels; Receptors, N-Methyl-D-Aspartate; Swimming; Tetraethylammonium | 2007 |
Time-dependent alteration in cromakalim-induced relaxation of corpus cavernosum from streptozocin-induced diabetic rats.
Topics: Animals; Cromakalim; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Glyburide; In Vitro Techniques; Male; Muscle Relaxation; Penis; Potassium Channels; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Exchanging ATPase; Streptozocin; Time Factors | 2007 |
Acute antihypertensive action of Tempol in the spontaneously hypertensive rat.
Topics: Amitrole; Animals; Antihypertensive Agents; Blood Pressure; Buthionine Sulfoximine; Catalase; Cromakalim; Cyclic N-Oxides; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ganglionic Blockers; Glutathione Peroxidase; Glyburide; Heart Rate; Heme Oxygenase (Decyclizing); Hexamethonium; Hypertension; Infusions, Intravenous; KATP Channels; Large-Conductance Calcium-Activated Potassium Channels; Male; Metalloporphyrins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peptides; Potassium Channel Blockers; Rats; Rats, Inbred SHR; Spin Labels; Sympathetic Nervous System; Time Factors | 2007 |
Mitochondrial ATP-sensitive K+ channels regulate NMDAR activity in the cortex of the anoxic western painted turtle.
Topics: Adenosine Triphosphate; Animals; Calcium; Cerebral Cortex; Cromakalim; Decanoic Acids; Diazoxide; Glyburide; Hydroxy Acids; Hypoxia; KATP Channels; Mitochondria, Heart; Patch-Clamp Techniques; Potassium Channel Blockers; Receptors, N-Methyl-D-Aspartate; Turtles | 2008 |
Molecular determinants for the activating/blocking actions of the 2H-1,4-benzoxazine derivatives, a class of potassium channel modulators targeting the skeletal muscle KATP channels.
Topics: Adenosine Triphosphate; Animals; Benzoxazines; Cromakalim; Glyburide; Male; Molecular Conformation; Molecular Structure; Muscle, Skeletal; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Wistar | 2008 |
Decreased expression of aortic KIR6.1 and SUR2B in hypertension does not correlate with changes in the functional role of K(ATP) channels.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; ATP-Binding Cassette Transporters; Blotting, Western; Cromakalim; Glyburide; Hypertension; Hypoglycemic Agents; Immunohistochemistry; KATP Channels; Male; Muscle, Smooth, Vascular; Patch-Clamp Techniques; Pinacidil; Potassium Channels, Inwardly Rectifying; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Drug; Sulfonylurea Receptors | 2008 |
Cromakalim activates the K(ATP) and enhances spontaneous transient outward potassium currents in rat saphenous arterial myocytes.
Topics: Animals; Arteries; Cromakalim; Glyburide; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Potassium; Potassium Channels; Rats; Rats, Wistar; Vasodilator Agents | 2008 |
Levcromakalim and MgGDP activate small conductance ATP-sensitive K+ channels of K+ channel pore 6.1/sulfonylurea receptor 2A in pig detrusor smooth muscle cells: uncoupling of cAMP signal pathways.
Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Calcitonin Gene-Related Peptide; Cromakalim; Cyclic AMP; Glyburide; Guanosine Diphosphate; KATP Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Signal Transduction; Sulfonylurea Receptors; Swine; Urinary Bladder | 2008 |
Roles of phosphatidylinositol 3-kinase-Akt and NADPH oxidase in adenosine 5'-triphosphate-sensitive K+ channel function impaired by high glucose in the human artery.
Topics: Antihypertensive Agents; Arteries; Chromones; Cromakalim; Enzyme Inhibitors; Glucose; Glyburide; Humans; Hyperglycemia; Hypoglycemic Agents; In Vitro Techniques; KATP Channels; Morpholines; Muscle, Smooth, Vascular; NADPH Oxidases; Omentum; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; rac1 GTP-Binding Protein; Signal Transduction; Superoxides | 2008 |
K(ATP)-mediated vasodilation is impaired in obese Zucker rats.
Topics: Animals; Arterioles; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Hypoglycemic Agents; Iloprost; Male; Muscle, Skeletal; Obesity; Phenylephrine; Potassium Channels; Rats; Rats, Zucker; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2008 |
ATP-sensitive potassium channels contribute to the time-dependent alteration in the pentylenetetrazole-induced seizure threshold in diabetic mice.
Topics: Analysis of Variance; Animals; Blood Glucose; Body Weight; Cromakalim; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Glyburide; Hypoglycemic Agents; KATP Channels; Male; Mice; Parasympatholytics; Pentylenetetrazole; Seizures; Time Factors | 2010 |
The role of ATP-sensitive potassium channel on acute urinary retention and subsequent catheterization in the rat.
Topics: Animals; Blood Circulation; Blood Pressure; Cromakalim; Dose-Response Relationship, Drug; Female; Glyburide; Ion Channel Gating; KATP Channels; Muscle Contraction; Nicorandil; Potassium Channel Blockers; Potassium Chloride; Rats; Rats, Sprague-Dawley; Urinary Bladder; Urinary Catheterization; Urinary Retention | 2010 |
Cellular coupling of potassium channels with beta2 adrenoceptors in mediating myometrial relaxation in buffaloes (Bubalus bubalis).
Topics: 4-Aminopyridine; Adrenergic beta-Agonists; Albuterol; Animals; Buffaloes; Cromakalim; Female; Glyburide; Hypoglycemic Agents; Muscle Relaxation; Myometrium; Parasympatholytics; Potassium Channels; Receptors, Adrenergic, beta-2; Tetraethylammonium; Uterine Contraction | 2010 |
Effects of K openers on the QT prolongation induced by HERG-blocking drugs in guinea-pigs.
Topics: Animals; Benzothiadiazines; Cromakalim; Decanoic Acids; Ether-A-Go-Go Potassium Channels; Glyburide; Guinea Pigs; Heart; Humans; Hydroxy Acids; Intracellular Membranes; KATP Channels; Long QT Syndrome; Male; Membrane Transport Modulators; Mitochondrial Membranes; Picolines; Pinacidil; Potassium Channel Blockers; Pyrans; Sarcolemma; Tolbutamide | 2010 |
Interaction of morphine and potassium channel openers on experimental models of pain in mice.
Topics: Animals; Calcium Channel Agonists; Cromakalim; Diazoxide; Drug Interactions; Drug Therapy, Combination; Female; Glyburide; Injections, Intraperitoneal; Male; Mice; Mice, Inbred Strains; Minoxidil; Morphine; Naloxone; Pain; Pain Measurement; Potassium Channels | 2011 |
Role of potassium channels in the antidepressant-like effect of folic acid in the forced swimming test in mice.
Topics: Animals; Antidepressive Agents; Apamin; Charybdotoxin; Cromakalim; Female; Folic Acid; Glyburide; Hypoglycemic Agents; Injections, Intraventricular; Male; Mice; Motor Activity; Potassium Channel Blockers; Potassium Channels; Swimming; Vasodilator Agents; Vitamins | 2012 |
Pharmacological preconditioning of ATP-sensitive potassium channel openers on acute urinary retention-induced bladder dysfunction in the rat.
Topics: Animals; Cromakalim; Glyburide; KATP Channels; Male; Nicorandil; Rats; Rats, Sprague-Dawley; Urinary Retention | 2012 |
The relaxant action of nicorandil in bovine tracheal smooth muscle.
Topics: Animals; Cattle; Cromakalim; Enzyme Inhibitors; Glyburide; Guanylate Cyclase; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth; Nicorandil; Nitroprusside; Oxadiazoles; Peptides; Quinoxalines; Trachea; Vasodilator Agents | 2012 |
CYP-epoxygenases contribute to A2A receptor-mediated aortic relaxation via sarcolemmal KATP channels.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Alcohol Oxidoreductases; Animals; Cromakalim; Decanoic Acids; Female; Glyburide; Hydroxy Acids; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidoreductases; Phenethylamines; Pinacidil; Receptor, Adenosine A2A; Sarcolemma | 2012 |
Reduced angiotensin II levels cause generalized vascular dysfunction via oxidant stress in hamster cheek pouch arterioles.
Topics: Acetylcholine; Angiotensin II; Animals; Arterioles; Blood Pressure; Captopril; Cheek; Cricetinae; Cromakalim; Endothelium, Vascular; Epoprostenol; Glyburide; Iloprost; Male; Mesocricetus; Microscopy; Microscopy, Video; Nitroprusside; Oxidants; Oxygen; Peptidyl-Dipeptidase A; Superoxides; Vascular Diseases | 2013 |
Impaired vascular KATP function attenuates exercise capacity in obese zucker rats.
Topics: Acetophenones; Animals; Cromakalim; Enzyme Inhibitors; Glyburide; Humans; Hypoglycemic Agents; Male; Muscle Contraction; NADPH Oxidases; Obesity; Physical Endurance; Potassium Channels; Rats; Rats, Zucker; Superoxides; Vasodilation; Vasodilator Agents | 2013 |
Significance of K(ATP) channels, L-type Ca²⁺ channels and CYP450-4A enzymes in oxygen sensing in mouse cremaster muscle arterioles in vivo.
Topics: Animals; Arterioles; Calcium Channels, L-Type; Cromakalim; Cytochrome P-450 Enzyme System; Glyburide; Hydroxyeicosatetraenoic Acids; KATP Channels; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Muscle, Smooth, Vascular; Nifedipine; Nitric Oxide Synthase; Oxygen; Retinoic Acid 4-Hydroxylase; Vasoconstriction; Vasodilation | 2013 |
Cholesterol-enriched diet inhibits cardioprotection by ATP-sensitive K+ channel activators cromakalim and diazoxide.
Topics: Adenosine Triphosphate; Animals; Cardiotonic Agents; Cholesterol, Dietary; Cromakalim; Decanoic Acids; Diazoxide; Diet, High-Fat; Glyburide; Hydroxy Acids; In Vitro Techniques; KATP Channels; Lactic Acid; Male; Myocardial Infarction; Oxidative Stress; Potassium Channel Blockers; Rats; Rats, Wistar | 2014 |
The effect of 5-HT and electrical field stimulation on the contractility of the whole isolated urinary bladder of Suncus murinus.
Topics: Adenosine Triphosphate; Animals; Atropine; Cromakalim; Electric Stimulation; Female; Glyburide; Male; Methysergide; Muscle Contraction; Phenols; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Shrews; Sulfonamides; Urinary Bladder | 2014 |
Blocking of the ATP sensitive potassium channel ameliorates the ischaemia-reperfusion injury in the rat testis.
Topics: Animals; Apoptosis; Cromakalim; Decanoic Acids; Diazoxide; Glyburide; Hydroxy Acids; KATP Channels; Male; Malondialdehyde; Neutrophil Infiltration; Oxidative Stress; Peroxidase; Potassium Channel Blockers; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Spermatic Cord Torsion; Testis | 2014 |
Opening of ATP-sensitive K(+) (KATP) channels enhance hydroxyl radical generation induced by MPP(+) in rat striatum.
Topics: Animals; Corpus Striatum; Cromakalim; Dopamine; Dose-Response Relationship, Drug; Glyburide; Hydroxybenzoates; Hydroxyl Radical; KATP Channels; Male; Membrane Transport Modulators; Microdialysis; MPTP Poisoning; Nicorandil; Rats, Wistar | 2016 |
The effect of nitrazepam on depression and curiosity in behavioral tests in mice: The role of potassium channels.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Cromakalim; Depression; Exploratory Behavior; Glyburide; Male; Mice; Nitrazepam; Potassium Channels | 2016 |
Cromakalim, a Potassium Channel Opener, Ameliorates the Organophosphate and Carbamate-Induced Seizure in Mice.
Topics: Animals; Anticonvulsants; Carbamates; Cromakalim; Dichlorvos; Dose-Response Relationship, Drug; Glyburide; Male; Mice; Organophosphate Poisoning; Physostigmine; Potassium Channels; Seizures | 2018 |
Chloroquine inhibits vasodilation induced by ATP-sensitive potassium channels in isolated rat aorta.
Topics: Animals; Aorta; Chloroquine; Cromakalim; Emulsions; Glyburide; Hydroxychloroquine; KATP Channels; Lipids; Potassium Channels; Rats; Reactive Oxygen Species; Vasodilation; Vasodilator Agents | 2023 |
Synthesis of and radioligand binding studies with a tritiated pinacidil analogue: receptor interactions of structurally different classes of potassium channel openers and blockers.
Topics: Animals; Binding Sites; Drug Interactions; Guanidines; Muscle, Smooth, Vascular; Pinacidil; Potassium Channels; Pyridines; Rats; Structure-Activity Relationship; Vasodilator Agents | 1993 |
A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; ATP-Binding Cassette Transporters; Cloning, Molecular; Gene Expression; Molecular Sequence Data; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Receptors, Drug; Recombinant Proteins; RNA, Messenger; Sequence Alignment; Sequence Homology, Amino Acid; Signal Transduction; Sulfonylurea Receptors; Tissue Distribution | 1996 |
Small molecule mitochondrial F1F0 ATPase hydrolase inhibitors as cardioprotective agents. Identification of 4-(N-arylimidazole)-substituted benzopyran derivatives as selective hydrolase inhibitors.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cardiotonic Agents; Cattle; Citrate (si)-Synthase; Electron Transport Complex IV; Hydrolysis; Imidazoles; In Vitro Techniques; Mitochondrial Proton-Translocating ATPases; Myocardial Contraction; Rats; Stereoisomerism; Structure-Activity Relationship | 2004 |