cromakalim has been researched along with diazoxide in 96 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (7.29) | 18.7374 |
| 1990's | 48 (50.00) | 18.2507 |
| 2000's | 29 (30.21) | 29.6817 |
| 2010's | 11 (11.46) | 24.3611 |
| 2020's | 1 (1.04) | 2.80 |
| Authors | Studies |
|---|---|
| Carroll, WA; Coghlan, MJ; Gopalakrishnan, M | 1 |
| Bouhedja, M; Boumendjel, A; Faury, G; Fhayli, W; Ghandour, Z; Khelili, S; Peres, B | 1 |
| Kozlowski, RZ; Nye, PC; Robertson, BE | 1 |
| Ashford, ML; Boden, PR; Sellers, AJ | 1 |
| Kato, H; Shimada, F; Takata, Y | 1 |
| Antoine, MH; Herchuelz, A; Lebrun, P | 1 |
| Bray, KM; Duty, S; Edwards, G; Longmore, J; Newgreen, DT; Weston, AH | 1 |
| Longmore, J; Newgreen, DT; Weston, AH | 1 |
| Bray, KM; Longmore, J; Weston, AH | 1 |
| Cavero, I; Mondot, S; Montier, F; Pratz, J | 1 |
| Bray, KM; Brown, BS; Duty, S; Edwards, G; Kay, PB; Longmore, J; McHarg, AD; Newgreen, DT; Southerton, JS; Weston, AH | 1 |
| Dunne, MJ; Gallacher, DV; Petersen, OH; Yule, DI | 2 |
| Aspinall, RJ; Dunne, MJ; Petersen, OH | 1 |
| Abele, AE; Miller, RJ | 1 |
| Baskin, EP; Garcia, ML; Heaney, LA; Kaczorowski, GJ; Stein, RB; Wallace, AA; Winquist, RJ | 1 |
| Cook, NS; Quast, U | 1 |
| Brayden, JE; Davies, NW; Huang, Y; Nelson, MT; Quayle, JM; Standen, NB | 1 |
| Garrino, MG; Henquin, JC; Plant, TD | 2 |
| Ashford, ML; Hales, CN; Kozlowski, RZ | 1 |
| de Tullio, P; Delarge, J; Dupont, L; Masereel, B; Pirotte, B | 1 |
| Attolini, L; Bruguerolle, B; Gantenbein, M | 1 |
| Avoli, M; Mattia, D; Nagao, T; Rogawski, MA | 1 |
| Link, H; Mix, E; Olsson, T; Zhu, J | 1 |
| Atwal, KS | 1 |
| Ashcroft, FM; Coles, B; Kenna, S; Proks, P; Reid, J; Röper, J; Smith, PA; Takano, M | 1 |
| Han, C; Xia, Y | 1 |
| Greenberg, DA; Koretz, B; Lustig, HS; von B Ahern, K; Wang, N | 1 |
| Clapham, JC; Hamilton, TC; Trail, BK | 1 |
| Alkadhi, KA; Salgado, D; Shek, EW | 1 |
| Ayton, BA; Dunne, MJ; Harding, EA; Jaggar, JH | 1 |
| Baeyens, JM; Barrios, M; Robles, LI | 1 |
| Ohno-Shosaku, T; Sawada, S; Yamamoto, C | 1 |
| Ducote, J; Harmon, CS; Lutz, D | 1 |
| Ayton, BJ; Dunne, MJ; Harding, EA; Jaggar, JH | 2 |
| Garlid, KD; Paucek, P; Schindler, PA; Sun, X; Yarov-Yarovoy, V | 1 |
| Brotchie, JM; Crossman, AR; Duty, S; Hille, CJ; Maneuf, YP | 1 |
| Garlid, KD; Paucek, P; Sun, X; Yarov-Yarovoy, V | 1 |
| Biggs, CS; Fowler, LJ; Maione, S; Rossi, F; Whitton, PS | 1 |
| Adler-Graschinsky, E; Feleder, EC | 1 |
| Anthony, DM; Buckett, WR; Dickinson, K; Jones, RB; Kaul, CL; Marita, AR | 1 |
| Matsumura, K; Mochizuki-Oda, N; Oosawa, Y; Takeuchi, Y; Watanabe, Y | 1 |
| D'Alonzo, AJ; Darbenzio, RB; Garlid, KD; Grover, GJ; Lodge, NJ; Murray, HN; Paucek, P; Smith, MA; Yarov-Yarovoy, V | 1 |
| Albert, A; De Tullio, P; Delarge, J; Dresse, A; Massotte, L; Pirotte, B; Scuvée-Moreau, J; Seutin, V; Vrijens, B | 1 |
| Grimmsmann, T; Rustenbeck, I | 1 |
| Beattie, DK; Davies, AH; Gosling, M; Powell, JT | 1 |
| Aguilar-Bryan, L; Babenko, AP; Bryan, J; Gonzalez, G | 1 |
| Chagneau, C; De Gottardi, A; Fléjou, JF; Fouassier, L; Housset, C; Lahaye, P; Lebrec, D; Moreau, R; Reichen, J; Rona, JP; Tazi, KA | 1 |
| Brioni, JD; Sullivan, JP; Zhu, DX | 1 |
| Abban, G; Akar, F; Buharalioğlu, CK; Heinemann, A; Holzer, P; Uydeş-Doğan, BS; Van de Voorde, J | 1 |
| Baertschi, AJ; Baron, A; Monnier, D; Roatti, A; van Bever, L | 1 |
| Foldes, FF; Matkó, I; Nagashima, H; Oe, K; Sántha, E; Sperlágh, B; Vizi, ES | 1 |
| Lohmann, AB; Welch, SP | 2 |
| D'hahan, N; Jacquet, H; Moreau, C; Prost, AL; Vivaudou, M | 1 |
| Ashcroft, FM; Gribble, FM | 1 |
| Asakura, M; Asanuma, H; Harada, K; Hori, M; Kitakaze, M; Kuzuya, T; Mori, H; Node, K; Ogita, H; Sakata, Y; Sanada, S; Shinozaki, Y; Takashima, S | 1 |
| Bajgar, R; Garlid, KD; Kowaltowski, AJ; Paucek, P; Seetharaman, S | 1 |
| Englert, H; Kilbinger, H; Krause, A; Mang, CF; Wirth, K | 1 |
| Auclair, J; Bouskela, E; Félétou, M; Levens, N; Néliat, G; Ravel, D | 1 |
| Busija, DW; Horiguchi, T; Kis, B; Nagy, K; Rajapakse, NC; Snipes, JA | 1 |
| Endre, ZH; Gobé, GC; Rahgozar, M; Willgoss, DA | 1 |
| Hambrock, A; Kayar, T; Osswald, H; Stumpp, D | 1 |
| Kobayashi, T; Ohta, Y | 1 |
| Avshalumov, MV; Chen, BT; Koós, T; Rice, ME; Tepper, JM | 1 |
| Dérand, R; Moreau, C; Prost, AL; Vivaudou, M | 1 |
| Aoyama, M; Furuzono, S; Imaizumi, Y; Ito, Y; Kajioka, S; Liu, HN; Matsubara, T; Murase, N; Nakayama, S; Nishizawa, Y; Ohya, S; Wang, J; Watanabe, T | 1 |
| Conte Camerino, D; Desai, RR; George, AL; Lundquist, AL; Mele, A; Tricarico, D | 1 |
| Brune, ME; Buckner, SA; Coghlan, M; Daza, A; Fey, TA; Gopalakrishnan, M; Milicic, I | 1 |
| Andrukhiv, A; Costa, AD; Garlid, KD; West, IC | 1 |
| Kukreja, RC | 1 |
| Ashcroft, FM; Conte Camerino, D; Desai, RR; George, AL; Liss, B; Lundquist, AL; Mele, A; Tricarico, D | 1 |
| Buck, LT; Cooray, M; Pamenter, ME; Shin, DS | 1 |
| Antoine, MH; Becker, B; de Tullio, P; Florence, X; Lebrun, P; Michaux, C; Pirotte, B; Sebille, S; Wouters, J | 1 |
| Gaisano, HY; Kang, Y; Ng, B; Sun, H; Xie, H | 1 |
| Ding, J; Duan, L; Hu, G; Huang, X; Qian, X; Xie, J | 1 |
| Florence, X; Lebrun, P; Pirotte, B; Sebille, S; Tullio, Pd | 1 |
| Garg, GR; Halder, S; Khanna, N; Malhotra, RS; Mehta, AK; Sharma, KK | 2 |
| de Tullio, P; Dilly, S; Florence, X; Lebrun, P; Pirotte, B | 1 |
| Amrutkar, DV; Baun, M; Gupta, S; Hay-Schmidt, A; Iversen, A; Jansen-Olesen, I; Lund, TM; Olesen, J; Ploug, KB; Ramachandran, R | 1 |
| Bencsik, P; Csonka, C; Csont, T; Ferdinandy, P; Görbe, A; Kupai, K; Pálóczi, J; Puskás, LG; Zvara, A | 1 |
| Honda, M; Inoue, K; Martin, DT; Oikawa, R; Saito, M; Sejima, T; Shimizu, S; Shimizu, T; Tanaka, K; Tomita, S; Tsounapi, P | 1 |
| Dosa, PI; Fautsch, MP; Roy Chowdhury, U | 1 |
| Anderson, KJ; Dosa, PI; Fautsch, MP; Holman, BH; Millar, JC; Roddy, GW; Roy Chowdhury, U | 1 |
| Andres, H; Bray, K; Manley, PW; Quast, U | 1 |
| Antoine, MH; Becker, B; Boverie, S; de Tullio, P; Lebrun, P; Pirotte, B; Sebille, S | 1 |
| Balsamo, A; Breschi, MC; Calderone, V; Martelli, A; Minutolo, F; Rapposelli, S; Testai, L; Tonelli, F | 1 |
| Abdelaziz, S; Bouhadja, M; de Tullio, P; Florence, X; Khelili, S; Lebrun, P; Mechouch, N; Mohamed, Y; Pirotte, B | 1 |
| Balsamo, A; Breschi, MC; Calderone, V; Digiacomo, M; Manganaro, M; Martelli, A; Minutolo, F; Rapposelli, S; Testai, L; Tonelli, F | 1 |
| Calderone, V; Cirilli, R; Digiacomo, M; Faggi, C; La Torre, F; Manganaro, M; Martelli, A; Rapposelli, S; Testai, L | 1 |
| Balsamo, A; Bianucci, AM; Calderone, V; Coi, A; Digiacomo, M; Rapposelli, S; Testai, L | 1 |
| de Tullio, P; Desvaux, V; Florence, X; Goffin, E; Lebrun, P; Pirotte, B | 1 |
| de Tullio, P; Florence, X; Goffin, E; Lebrun, P; Medeiros, MB; Pirotte, B | 1 |
6 review(s) available for cromakalim and diazoxide
| Article | Year |
|---|---|
Recent developments in the biology and medicinal chemistry of potassium channel modulators: update from a decade of progress.
Topics: Adenosine Triphosphate; Angina Pectoris; Arrhythmias, Cardiac; Asthma; Calcium; Ion Channel Gating; Myocardial Ischemia; Potassium Channel Blockers; Potassium Channels; Urinary Incontinence | 2001 |
The potassium channel openers: a new class of vasorelaxants.
Topics: Animals; Benzopyrans; Cromakalim; Diazoxide; Galanin; Membrane Potentials; Peptides; Potassium Channels; Potassium Chloride; Pyrroles; Rubidium Radioisotopes; Vasodilator Agents | 1990 |
Pharmacology and structure-activity relationships for KATP modulators: tissue-selective KATP openers.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Antihypertensive Agents; Benzopyrans; Cardiovascular Diseases; Cromakalim; Diazoxide; Guanidines; Guinea Pigs; Minoxidil; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Picolines; Pinacidil; Potassium Channels; Pyrans; Pyrroles; Radioligand Assay; Rats; Structure-Activity Relationship; Vasodilator Agents | 1994 |
New windows on the mechanism of action of K(ATP) channel openers.
Topics: Adenosine Triphosphate; Animals; Binding Sites; Cromakalim; Diazoxide; Humans; Minoxidil; Nicorandil; Pinacidil; Potassium Channels | 2000 |
SUR, ABC proteins targeted by KATP channel openers.
Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Cromakalim; Cytoplasm; Diazoxide; Down-Regulation; Humans; KATP Channels; Models, Biological; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Binding; Protein Isoforms; Protein Structure, Secondary; Protein Structure, Tertiary; Receptors, Drug; Sulfonylurea Receptors; Up-Regulation | 2005 |
ATP sensitive potassium channel openers: A new class of ocular hypotensive agents.
Topics: Animals; Antihypertensive Agents; Cromakalim; Diazoxide; Glaucoma; Humans; Intraocular Pressure; KATP Channels; Nicorandil; Trabecular Meshwork | 2017 |
90 other study(ies) available for cromakalim and diazoxide
| Article | Year |
|---|---|
Design, synthesis and biological evaluation of novel ring-opened cromakalim analogues with relaxant effects on vascular and respiratory smooth muscles and as stimulators of elastin synthesis.
Topics: Animals; Cromakalim; Dose-Response Relationship, Drug; Drug Design; Elastin; Female; Molecular Structure; Muscle Contraction; Muscle, Smooth; Rats; Rats, Wistar; Structure-Activity Relationship | 2018 |
Opposing actions of tolbutamide and glibenclamide on hypoxic pulmonary vasoconstriction.
Topics: Animals; Benzopyrans; Cromakalim; Diazoxide; Glyburide; Hypoxia; In Vitro Techniques; Lung; Male; Potassium Channels; Pyrroles; Rats; Tolbutamide; Vasoconstriction | 1992 |
Lack of effect of potassium channel openers on ATP-modulated potassium channels recorded from rat ventromedial hypothalamic neurones.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Cromakalim; Diazoxide; Guanidines; Hypothalamus, Middle; In Vitro Techniques; Male; Membrane Potentials; Minoxidil; Neurons; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1992 |
Differential effects of diazoxide, cromakalim and pinacidil on adrenergic neurotransmission and 86Rb+ efflux in rat brain cortical slices.
Topics: Animals; Benzopyrans; Cerebral Cortex; Cocaine; Cromakalim; Diazoxide; Electric Stimulation; Glyburide; Guanidines; Hydrocortisone; In Vitro Techniques; Male; Norepinephrine; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Rubidium Radioisotopes | 1992 |
Anoxia and glucose-sensitive 86Rb outflow from rat portal vein.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Diazoxide; Glucose; Guanidines; Hypoxia; Permeability; Pinacidil; Portal Vein; Potassium; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Rubidium Radioisotopes | 1992 |
Effects of cromakalim, RP49356, diazoxide, glibenclamide and galanin in rat portal vein.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Diazoxide; Galanin; Glyburide; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Peptides; Picolines; Portal Vein; Potassium Channels; Pyrans; Pyrroles; Rats; Rats, Inbred Strains; Rubidium Radioisotopes; Vasodilator Agents | 1990 |
The contribution of Rb-permeable potassium channels to the relaxant and membrane hyperpolarizing actions of cromakalim, RP49356 and diazoxide in bovine tracheal smooth muscle.
Topics: Animals; Benzopyrans; Cattle; Cromakalim; Diazoxide; Electrophysiology; In Vitro Techniques; Isometric Contraction; Muscle, Smooth; Picolines; Potassium Channels; Potassium Radioisotopes; Pyrans; Pyrroles; Rubidium; Rubidium Radioisotopes; Trachea | 1991 |
Effects of the K+ channel activators, RP 52891, cromakalim and diazoxide, on the plasma insulin level, plasma renin activity and blood pressure in rats.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Blood Glucose; Blood Pressure; Cromakalim; Diazoxide; Drug Interactions; Glucose; Glyburide; Infusions, Intravenous; Insulin; Male; Membrane Potentials; Picolines; Potassium Channels; Pyrans; Pyrroles; Rats; Renin | 1991 |
The action of diazoxide and minoxidil sulphate on rat blood vessels: a comparison with cromakalim.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Benzopyrans; Cromakalim; Cyclic AMP; Cyclic GMP; Diazoxide; Glyburide; In Vitro Techniques; Male; Membrane Potentials; Microelectrodes; Minoxidil; Muscle, Smooth, Vascular; Portal Vein; Potassium Channels; Potassium Radioisotopes; Pyrroles; Rabbits; Rats; Rats, Inbred Strains; Rubidium Radioisotopes | 1990 |
Comparative study of the effects of cromakalim (BRL 34915) and diazoxide on membrane potential, [Ca2+]i and ATP-sensitive potassium currents in insulin-secreting cells.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Cell Line; Cromakalim; Diazoxide; Glucose; Islets of Langerhans; Kinetics; Membrane Potentials; Potassium Channels; Pyrroles; Tolbutamide | 1990 |
The effects of cromakalim on ATP-sensitive potassium channels in insulin-secreting cells.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Benzopyrans; Cell Line; Cromakalim; Diazoxide; Insulin; Insulin Secretion; Islets of Langerhans; Potassium Channels; Potassium Radioisotopes; Pyrroles; Rubidium Radioisotopes; Sodium | 1990 |
Potassium channel activators abolish excitotoxicity in cultured hippocampal pyramidal neurons.
Topics: Action Potentials; Animals; Benzopyrans; Cell Survival; Cells, Cultured; Cromakalim; Diazoxide; Hippocampus; Potassium Channels; Pyrroles; Rats | 1990 |
Glyburide blocks the relaxation response to BRL 34915 (cromakalim), minoxidil sulfate and diazoxide in vascular smooth muscle.
Topics: 4-Aminopyridine; Adenosine Triphosphate; Aminopyridines; Animals; Antihypertensive Agents; Benzopyrans; Charybdotoxin; Cromakalim; Diazoxide; Glyburide; Male; Minoxidil; Muscle, Smooth, Vascular; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Scorpion Venoms; Tetraethylammonium; Tetraethylammonium Compounds; Vasodilation | 1989 |
In vitro and in vivo comparison of two K+ channel openers, diazoxide and cromakalim, and their inhibition by glibenclamide.
Topics: Angiotensin II; Animals; Aorta; Benzopyrans; Blood Pressure; Cromakalim; Diazoxide; Glyburide; Heart Rate; In Vitro Techniques; Muscle, Smooth, Vascular; Norepinephrine; Portal Vein; Potassium Channels; Pyrroles; Rabbits; Rats; Rats, Inbred SHR; Rubidium; Vasoconstriction | 1989 |
Hyperpolarizing vasodilators activate ATP-sensitive K+ channels in arterial smooth muscle.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Benzopyrans; Cerebral Arteries; Cromakalim; Diazoxide; Glyburide; Guanidines; Mesenteric Arteries; Muscle, Smooth, Vascular; Pinacidil; Potassium Channels; Pyrroles; Rabbits; Rats; Tolbutamide; Vasoactive Intestinal Peptide; Vasodilator Agents | 1989 |
Comparison of the effects of putative activators of K+ channels on pancreatic B-cell function.
Topics: Animals; Benzopyrans; Cromakalim; Diazoxide; Guanidines; In Vitro Techniques; Islets of Langerhans; Mice; Minoxidil; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1989 |
Effects of putative activators of K+ channels in mouse pancreatic beta-cells.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Diazoxide; Electrophysiology; Female; Glucose; Guanidines; Homeostasis; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Membrane Potentials; Mice; Minoxidil; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Rubidium Radioisotopes | 1989 |
Cromakalim (BRL 34915) and diazoxide activate ATP-regulated potassium channels in insulin-secreting cells.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cell Line; Cromakalim; Diazoxide; Insulin; Insulin Secretion; Islets of Langerhans; Potassium Channels; Pyrroles; Vasodilator Agents | 1989 |
Dual effects of diazoxide on ATP-K+ currents recorded from an insulin-secreting cell line.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Biotransformation; Cell Line; Cells, Cultured; Cromakalim; Diazoxide; Insulin; Insulin Secretion; Islets of Langerhans; Magnesium; Membrane Potentials; Potassium Channels; Pyrroles; Rats; Solutions | 1989 |
[Potassium channel activators: comparative structural study of pinacidil, diazoxide and cromakalim].
Topics: Antihypertensive Agents; Benzopyrans; Cromakalim; Diazoxide; Guanidines; Molecular Conformation; Molecular Structure; Pinacidil; Potassium Channels; Pyrroles | 1995 |
Effect of four potassium channel agonists on bupivacaine-induced toxicity in mice.
Topics: Animals; Benzopyrans; Bupivacaine; Cromakalim; Diazoxide; Dose-Response Relationship, Drug; Guanidines; Male; Mice; Mice, Inbred Strains; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Seizures | 1995 |
Potassium channel activators counteract anoxic hyperexcitability but not 4-aminopyridine-induced epileptiform activity in the rat hippocampal slice.
Topics: 4-Aminopyridine; Animals; Benzopyrans; Cromakalim; Diazoxide; Epilepsy; Hippocampus; Hypoxia, Brain; In Vitro Techniques; Male; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley | 1994 |
Influence of K+ channel openers on interferon-gamma dependent immune response in experimental allergic neuritis (EAN).
Topics: Animals; Benzopyrans; Cromakalim; Diazoxide; Guanidines; Interferon-gamma; Ion Channel Gating; Lymph Nodes; Lymphocyte Activation; Neuritis, Autoimmune, Experimental; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred Lew | 1994 |
The KATP and Kv channels are distinct entities: a reply to Edwards and Weston.
Topics: Action Potentials; Animals; Benzopyrans; Cromakalim; Diazoxide; Ion Channel Gating; Islets of Langerhans; Mice; Muscle, Smooth, Vascular; Phosphorylation; Potassium Channels; Pyrroles; Vasodilator Agents | 1994 |
Role of K+ channels in neuropeptide Y-induced vasoconstriction in rabbit cerebral basilar artery.
Topics: Animals; Basilar Artery; Benzopyrans; Blood Pressure; Cromakalim; Diazoxide; Female; In Vitro Techniques; Male; Membrane Potentials; Muscle Relaxation; Muscle, Smooth, Vascular; Neuropeptide Y; Potassium Channels; Pyrroles; Rabbits; Vasoconstrictor Agents | 1994 |
Pre- and post-synaptic modulators of excitatory neurotransmission: comparative effects on hypoxia/hypoglycemia in cortical cultures.
Topics: Animals; Aspartic Acid; Benzopyrans; Calcium Channel Blockers; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Cromakalim; Diazoxide; Embryo, Mammalian; Glutamates; Hypoglycemia; Kainic Acid; Kinetics; L-Lactate Dehydrogenase; Neurons; Potassium Channels; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission; Time Factors | 1994 |
K+ channel activators, acute glucose tolerance and glibenclamide-induced hypoglycaemia in the hypertensive rat.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Benzopyrans; Blood Glucose; Blood Pressure; Cromakalim; Diazoxide; Dose-Response Relationship, Drug; Glucose Tolerance Test; Glyburide; Guanidines; Hypertension; Hypoglycemia; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred SHR | 1994 |
Effects of ATP-sensitive K(+)-channel activators on transmitter release parameters at the frog neuromuscular junction.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Diazoxide; Glyburide; In Vitro Techniques; Membrane Potentials; Motor Endplate; Muscles; Neuromuscular Junction; Neurotransmitter Agents; Parasympatholytics; Potassium Channels; Pyrroles; Rana pipiens | 1993 |
Activation of potassium channels by diazoxide and cromakalim in insulin-secreting cells is dependent upon internal ADP and channel run-down.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Benzopyrans; Cell Line; Cromakalim; Diazoxide; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Kinetics; Pancreatic Neoplasms; Potassium Channels; Pyrroles; Tumor Cells, Cultured | 1993 |
ATP-sensitive K+ channel openers inhibit morphine withdrawal.
Topics: Adenosine Triphosphate; Animals; Behavior, Animal; Benzopyrans; Body Weight; Cromakalim; Diazoxide; Dose-Response Relationship, Drug; Female; Injections, Intraventricular; Injections, Subcutaneous; Mice; Mice, Inbred Strains; Morphine; Naloxone; Potassium Channels; Pyrroles; Substance Withdrawal Syndrome | 1994 |
ATP-sensitive K+ channel activators suppress the GABAergic inhibitory transmission by acting on both presynaptic and postsynaptic sites in rat cultured hippocampal neurons.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Animals, Newborn; Benzopyrans; Cells, Cultured; Cromakalim; Diazoxide; gamma-Aminobutyric Acid; Hippocampus; Neurons; Potassium Channels; Pyrroles; Rats; Receptors, Presynaptic; Synapses; Synaptic Transmission | 1993 |
Potassium channel openers stimulate DNA synthesis in mouse epidermal keratinocyte and whole hair follicle cultures.
Topics: Animals; Benzopyrans; Cells, Cultured; Cromakalim; Diazoxide; DNA; Guanidines; Hair; Keratinocytes; Kinetics; Mice; Minoxidil; Pinacidil; Potassium Channels; Pyrroles; Vibrissae | 1993 |
Properties of diazoxide and cromakalim-induced activation of potassium channels in cultured rat and RINm5F insulin-secreting cells; effects of GTP.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cells, Cultured; Cromakalim; Diazoxide; Guanosine Triphosphate; Insulin; Insulin Secretion; Islets of Langerhans; Pertussis Toxin; Potassium Channels; Pyrroles; Rats; Virulence Factors, Bordetella | 1993 |
Interaction of diazoxide and cromakalim with ATP-regulated K+ channels in rodent and clonal insulin-secreting cells.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Benzopyrans; Cells, Cultured; Cromakalim; Diazoxide; Insulin; Insulin Secretion; Islets of Langerhans; Models, Biological; Potassium Channels; Pyrroles; Rats | 1993 |
The mitochondrial KATP channel as a receptor for potassium channel openers.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cattle; Cell-Free System; Cromakalim; Diazoxide; Liposomes; Mitochondria; Mitochondria, Heart; Mitochondria, Liver; Potassium; Potassium Channels; Pyrroles; Rats | 1996 |
Modulation of GABA transmission by diazoxide and cromakalim in the globus pallidus: implications for the treatment of Parkinson's disease.
Topics: Animals; Antihypertensive Agents; Behavior, Animal; Benzopyrans; Cromakalim; Diazoxide; Disease Models, Animal; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Globus Pallidus; Ion Channel Gating; Locomotion; Male; Parkinson Disease; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Reserpine; Time Factors | 1996 |
Inhibition of the mitochondrial KATP channel by long-chain acyl-CoA esters and activation by guanine nucleotides.
Topics: Acyl Coenzyme A; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Diazoxide; Guanosine Diphosphate; Guanosine Triphosphate; Magnesium; Mitochondria, Liver; Palmitoyl Coenzyme A; Potassium; Potassium Channel Blockers; Pyrroles; Rats | 1996 |
AMPA receptors modulate extracellular 5-hydroxytryptamine concentration and metabolism in rat striatum in vivo.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Antihypertensive Agents; Benzopyrans; Corpus Striatum; Cromakalim; Diazoxide; Excitatory Amino Acid Antagonists; Hydroxyindoleacetic Acid; Male; Pyrroles; Rats; Rats, Wistar; Receptors, AMPA; Serotonin; Vasodilator Agents | 1997 |
Endothelium-mediated and N omega-nitro-L-arginine methyl ester-sensitive responses to cromakalim and diazoxide in the rat mesenteric bed.
Topics: Adrenergic alpha-Agonists; Animals; Benzopyrans; Cromakalim; Diazoxide; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Hypoglycemic Agents; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Norepinephrine; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Wistar; Splanchnic Circulation; Vascular Resistance; Vasodilator Agents | 1997 |
Evaluation of BTS 67 582, a novel antidiabetic agent, in normal and diabetic rats.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Blood Glucose; Brain; Cromakalim; Diabetes Mellitus, Experimental; Diazoxide; Glucose; Glyburide; Guanidines; Hypoglycemic Agents; In Vitro Techniques; Insulin; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Channel Blockers; Pyrroles; Rats; Rats, Wistar; Tumor Cells, Cultured | 1997 |
Hypoxia-induced catecholamine release and intracellular Ca2+ increase via suppression of K+ channels in cultured rat adrenal chromaffin cells.
Topics: Animals; Benzopyrans; Buffers; Calcium; Carotid Body; Catecholamines; Cell Hypoxia; CHO Cells; Chromaffin Cells; Cricetinae; Cromakalim; Diazoxide; Glioma; Glyburide; Guanidines; Hybrid Cells; Hypoglycemic Agents; Male; Membrane Potentials; Minoxidil; Neuroblastoma; Parasympatholytics; Patch-Clamp Techniques; Pinacidil; Potassium; Potassium Channel Blockers; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Vasodilator Agents | 1997 |
Cardioprotective effect of diazoxide and its interaction with mitochondrial ATP-sensitive K+ channels. Possible mechanism of cardioprotection.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Cattle; Cromakalim; Diazoxide; Male; Mitochondria, Heart; Potassium Channels; Rats; Rats, Sprague-Dawley | 1997 |
Effect of potassium channel openers on the firing rate of hippocampal pyramidal cells and A10 dopaminergic neurons in vitro.
Topics: Action Potentials; Animals; Cromakalim; Diazoxide; Dopamine; Guanidines; Hippocampus; In Vitro Techniques; Male; Neurons; Pinacidil; Potassium Channels; Pyramidal Cells; Pyridines; Rats; Rats, Wistar; Thiadiazines; Ventral Tegmental Area | 1997 |
Direct effects of diazoxide on mitochondria in pancreatic B-cells and on isolated liver mitochondria.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Channel Blockers; Cromakalim; Diazoxide; Gallopamil; Guanidines; In Vitro Techniques; Islets of Langerhans; Membrane Potentials; Mice; Mice, Obese; Mitochondria; Mitochondria, Liver; Oxidative Phosphorylation; Pinacidil; Potassium Channels; Rats; Rhodamine 123; Rhodamines | 1998 |
The effects of potassium channel openers on saphenous vein exposed to arterial flow.
Topics: Arteries; Blood Flow Velocity; Chromans; Cromakalim; Diazoxide; Guanidines; Humans; In Vitro Techniques; Phenylephrine; Pinacidil; Potassium Channels; Pyrrolidines; Saphenous Vein; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 1998 |
Reconstituted human cardiac KATP channels: functional identity with the native channels from the sarcolemma of human ventricular cells.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adolescent; Adult; Animals; ATP-Binding Cassette Transporters; Child; CHO Cells; Cloning, Molecular; COS Cells; Cricetinae; Cromakalim; Diazoxide; DNA, Complementary; Gene Library; Glyburide; Heart Ventricles; Humans; Magnesium; Middle Aged; Myocardium; Patch-Clamp Techniques; Pinacidil; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Receptors, Drug; Sarcolemma; Sulfonylurea Receptors; Tolbutamide; Transfection | 1998 |
Endothelium-dependent blunted membrane potential responses to ATP-sensitive K+ channel modulators in aortae from rats with cirrhosis.
Topics: Adenosine Triphosphate; Animals; Aorta; Bosentan; Cromakalim; Diazoxide; Endothelin-1; Endothelium, Vascular; Glyburide; Liver Cirrhosis, Experimental; Male; Membrane Potentials; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; Sulfonamides; Tolbutamide | 1999 |
ATP-sensitive potassium channels regulate in vivo dopamine release in rat striatum.
Topics: Adenosine Triphosphate; Animals; Consciousness; Cromakalim; Dextroamphetamine; Diazoxide; Dopamine; Dopamine Uptake Inhibitors; Glyburide; Hypoglycemic Agents; Injections, Subcutaneous; Male; Microdialysis; Movement; Neostriatum; Potassium Channels; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1999 |
Protective effect of cromakalim and diazoxide, and proulcerogenic effect of glibenclamide on indomethacin-induced gastric injury.
Topics: Animals; Arteries; Blood Glucose; Blood Pressure; Cromakalim; Diazoxide; Dose-Response Relationship, Drug; Gastric Mucosa; Gastrointestinal Agents; Glyburide; Hypoglycemic Agents; Indomethacin; Male; Neutrophils; Peroxidase; Rats; Regional Blood Flow; Stomach; Stomach Diseases; Vasodilation; Vasodilator Agents | 1999 |
A novel K(ATP) current in cultured neonatal rat atrial appendage cardiomyocytes.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Atrial Appendage; Cells, Cultured; Cromakalim; Diazoxide; Electric Conductivity; Glyburide; Hypotonic Solutions; Physical Stimulation; Potassium Channels; Protein Isoforms; Rats | 1999 |
Modulation of norepinephrine release by ATP-dependent K(+)-channel activators and inhibitors in guinea-pig and human isolated right atrium.
Topics: Adenosine; Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-2 Receptor Agonists; Analysis of Variance; Animals; Clonidine; Cromakalim; Decanoic Acids; Diazoxide; Dose-Response Relationship, Drug; Glyburide; Guinea Pigs; Heart Atria; Humans; Hydroxy Acids; In Vitro Techniques; Male; Muscarinic Agonists; Norepinephrine; Oxotremorine; Pinacidil; Potassium Channel Blockers; Potassium Channels; Stimulation, Chemical; Sympathetic Nervous System | 1999 |
ATP-gated K(+) channel openers enhance opioid antinociception: indirect evidence for the release of endogenous opioid peptides.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenosine Triphosphate; Analgesics; Animals; Cromakalim; Diazoxide; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Glyburide; Injections, Intraventricular; Ion Channel Gating; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Opioid Peptides; Pain; Potassium Channels; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin | 1999 |
Antisenses to opioid receptors attenuate ATP-gated K(+) channel opener-induced antinociception.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenosine Triphosphate; Analgesia; Analgesics; Animals; Cromakalim; Diazoxide; Enkephalin, D-Penicillamine (2,5)-; Male; Mice; Mice, Inbred ICR; Morphine; Nociceptors; Oligodeoxyribonucleotides, Antisense; Pain; Potassium Channels; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1999 |
The molecular basis of the specificity of action of K(ATP) channel openers.
Topics: Amino Acid Sequence; Animals; ATP-Binding Cassette Transporters; Cell Membrane; Cricetinae; Cromakalim; Diazoxide; Ion Channel Gating; Mice; Models, Molecular; Molecular Sequence Data; Muscle, Skeletal; Mutagenesis, Site-Directed; Neurons; Nicorandil; Oocytes; Pancreas; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Isoforms; Protein Structure, Secondary; Rats; Receptors, Drug; Recombinant Fusion Proteins; Sulfonylurea Receptors | 2000 |
Role of mitochondrial and sarcolemmal K(ATP) channels in ischemic preconditioning of the canine heart.
Topics: Adenosine Triphosphate; Animals; Calcium Channel Blockers; Collateral Circulation; Coronary Circulation; Cromakalim; Decanoic Acids; Diazoxide; Dogs; Heart; Hemodynamics; Hydroxy Acids; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Mitochondria, Heart; Myocardial Infarction; Myocardial Reperfusion Injury; Nicorandil; Potassium Channel Blockers; Potassium Channels; Sarcolemma; Vasodilator Agents | 2001 |
Identification and properties of a novel intracellular (mitochondrial) ATP-sensitive potassium channel in brain.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Boron Compounds; Brain; Cromakalim; Decanoic Acids; Diazoxide; Fluorescent Dyes; Glyburide; Guanosine Triphosphate; Hydroxy Acids; Kinetics; Ligands; Liver; Membrane Proteins; Mitochondria; Mitochondria, Liver; Models, Biological; Myocardium; Oxygen Consumption; Potassium Channels; Proteolipids; Rats; Time Factors; Vasodilator Agents | 2001 |
Effects of K(ATP) channel modulators on acetylcholine release from guinea-pig isolated atria and small intestine.
Topics: Acetylcholine; Animals; Atrial Function; Cromakalim; Diazoxide; Female; Glyburide; Guinea Pigs; Heart Atria; In Vitro Techniques; Intestine, Small; Male; Muscle, Smooth; Myenteric Plexus; Myocardial Contraction; Neuromuscular Junction; Pinacidil; Potassium Channel Blockers; Potassium Channels; Sulfonamides; Thiourea | 2002 |
Differential effects of sulphonylureas on the vasodilatory response evoked by K(ATP) channel openers.
Topics: Adenosine Triphosphate; Animals; Aorta, Thoracic; Cricetinae; Cromakalim; Diazoxide; Drug Interactions; Gliclazide; Glyburide; Guinea Pigs; Hypoglycemic Agents; In Vitro Techniques; Ion Channel Gating; Male; Potassium Channels; Rats; Rats, Wistar; Species Specificity; Sulfonylurea Compounds; Vasodilation; Vasodilator Agents | 2003 |
Diazoxide induces delayed pre-conditioning in cultured rat cortical neurons.
Topics: Animals; Cell Death; Cell Hypoxia; Cell Survival; Cells, Cultured; Cerebral Cortex; Cromakalim; Decanoic Acids; Diazoxide; Enzyme Activation; Enzyme Inhibitors; Glucose; Glyburide; Hydroxy Acids; Ischemic Preconditioning; Mitochondria; Neurons; Neuroprotective Agents; Nicorandil; Nitro Compounds; Oxidative Stress; Propionates; Rats; Rats, Wistar; Succinate Dehydrogenase; Superoxides; Time Factors | 2003 |
ATP-dependent K+ channels in renal ischemia reperfusion injury.
Topics: Acute Kidney Injury; Adenosine Triphosphate; Animals; Cromakalim; Diazoxide; Disease Models, Animal; Glomerular Filtration Rate; Glyburide; Kidney; Kidney Function Tests; Male; Organ Culture Techniques; Potassium Channels; Probability; Rats; Rats, Sprague-Dawley; Reference Values; Reperfusion Injury; Sensitivity and Specificity | 2003 |
Effect of two amino acids in TM17 of Sulfonylurea receptor SUR1 on the binding of ATP-sensitive K+ channel modulators.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; ATP-Binding Cassette Transporters; Binding Sites; Cell Line; Chromans; Cromakalim; Diazoxide; Glyburide; Humans; Kinetics; Models, Molecular; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Mutagenesis, Site-Directed; Oocytes; Potassium Channels, Inwardly Rectifying; Protein Conformation; Protein Structure, Secondary; Pyrrolidines; Rats; Receptors, Drug; Recombinant Proteins; Sulfonylurea Receptors; Transfection; Xenopus | 2004 |
150-kD oxygen-regulated protein is an essential factor for insulin release.
Topics: Adenoviridae; Animals; Antisense Elements (Genetics); Cell Line, Tumor; Cromakalim; Diazoxide; Genes, Reporter; Glucose; HSP70 Heat-Shock Proteins; Insulin; Insulin Secretion; Insulin-Secreting Cells; Insulinoma; Mice; Pinacidil; Potassium Channels; Proteins; Vasodilator Agents | 2005 |
Endogenous hydrogen peroxide regulates the excitability of midbrain dopamine neurons via ATP-sensitive potassium channels.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Cromakalim; Diazoxide; Dopamine; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Glutathione Peroxidase; Glyburide; Guinea Pigs; Hydrogen Peroxide; Hypoglycemic Agents; In Vitro Techniques; Isoquinolines; Membrane Potentials; Mesencephalon; Neurons; Organoplatinum Compounds; Patch-Clamp Techniques; Potassium Channels; Tetrodotoxin; Thiomalates; Time Factors; Vasodilator Agents | 2005 |
Sulphonylurea receptors differently modulate ICC pacemaker Ca2+ activity and smooth muscle contractility.
Topics: Animals; ATP-Binding Cassette Transporters; Base Sequence; Calcium; Calcium Channels; Cells, Cultured; Cromakalim; Diazoxide; Ileum; Immunohistochemistry; KATP Channels; Mice; Mice, Inbred BALB C; Multidrug Resistance-Associated Proteins; Muscle Contraction; Muscle, Smooth; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Reverse Transcriptase Polymerase Chain Reaction; Sulfonylurea Receptors | 2005 |
Hybrid assemblies of ATP-sensitive K+ channels determine their muscle-type-dependent biophysical and pharmacological properties.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; ATP-Binding Cassette Transporters; Biophysics; Cromakalim; Diazoxide; DNA Primers; Dose-Response Relationship, Drug; Gene Expression Regulation; Glyburide; Hypoglycemic Agents; KATP Channels; Kinetics; Male; Models, Statistical; Muscle Fibers, Skeletal; Muscle, Skeletal; Muscles; Patch-Clamp Techniques; Phenotype; Potassium; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Wistar; Receptors, Drug; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; Sulfonylurea Receptors; Tolbutamide | 2006 |
Pharmacological characterization of urinary bladder smooth muscle contractility following partial bladder outlet obstruction in pigs.
Topics: Adenosine Triphosphate; Amides; Animals; Benzophenones; Carbachol; Cholinergic Agonists; Cromakalim; Cyclic S-Oxides; Diazoxide; Dose-Response Relationship, Drug; Electric Stimulation; Female; Guanidines; Histamine; Hypertrophy; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Potassium Channels; Potassium Chloride; Pyridines; Quinolones; Serotonin; Serotonin Agents; Swine; Urinary Bladder; Urinary Bladder Neck Obstruction; Vasodilator Agents | 2006 |
Opening mitoKATP increases superoxide generation from complex I of the electron transport chain.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Antifungal Agents; Cromakalim; Cyclic GMP-Dependent Protein Kinases; Decanoic Acids; Diazoxide; Electron Transport Complex I; Fluorescent Dyes; Hydrogen-Ion Concentration; Hydroxy Acids; Ionophores; Male; Methacrylates; Mitochondria, Heart; Mitochondria, Liver; Models, Biological; Potassium Channels; Protein Kinase C; Rats; Rats, Sprague-Dawley; Superoxides; Thiazoles; Valinomycin; Vasodilator Agents | 2006 |
Mechanism of reactive oxygen species generation after opening of mitochondrial KATP channels.
Topics: Adenosine Triphosphate; Animals; Cromakalim; Cyclic GMP-Dependent Protein Kinases; Diazoxide; Dose-Response Relationship, Drug; Electron Transport Complex I; Fluorescent Dyes; Hydrogen Peroxide; Hydrogen-Ion Concentration; Ionophores; Male; Mitochondria, Heart; Mitochondria, Liver; Oxidants; Potassium Channels; Protein Kinase C; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Valinomycin; Vasodilator Agents | 2006 |
Reduced expression of Kir6.2/SUR2A subunits explains KATP deficiency in K+-depleted rats.
Topics: Animals; Cromakalim; Diazoxide; Hypokalemic Periodic Paralysis; KATP Channels; Male; Membrane Potentials; Muscle, Skeletal; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Potassium Deficiency; Rats; Rats, Wistar; Sarcolemma; Vasodilator Agents | 2008 |
Mitochondrial ATP-sensitive K+ channels regulate NMDAR activity in the cortex of the anoxic western painted turtle.
Topics: Adenosine Triphosphate; Animals; Calcium; Cerebral Cortex; Cromakalim; Decanoic Acids; Diazoxide; Glyburide; Hydroxy Acids; Hypoxia; KATP Channels; Mitochondria, Heart; Patch-Clamp Techniques; Potassium Channel Blockers; Receptors, N-Methyl-D-Aspartate; Turtles | 2008 |
New R/S-3,4-dihydro-2,2-dimethyl-6-halo-4-(phenylaminothiocarbonylamino)-2H-1-benzopyrans structurally related to (+/-)-cromakalim as tissue-selective pancreatic beta-cell K(ATP) channel openers.
Topics: Animals; Aorta; ATP-Binding Cassette Transporters; Benzopyrans; Cromakalim; Diazoxide; Drug Evaluation, Preclinical; Insulin-Secreting Cells; Molecular Structure; Pinacidil; Potassium Channels; Quantum Theory; Rats; Rats, Wistar; Stereoisomerism; Structure-Activity Relationship; Temperature; Time Factors | 2008 |
Syntaxin-1A inhibition of P-1075, cromakalim, and diazoxide actions on mouse cardiac ATP-sensitive potassium channel.
Topics: Animals; Cell Line; Cells, Cultured; Cromakalim; Diazoxide; Dose-Response Relationship, Drug; Guanidines; Humans; KATP Channels; Kidney; Male; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; Patch-Clamp Techniques; Potassium Channels, Inwardly Rectifying; Pyridines; Syntaxin 1; Vasodilator Agents | 2008 |
K(ATP) channel openers protect mesencephalic neurons against MPP+-induced cytotoxicity via inhibition of ROS production.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Cells, Cultured; Cromakalim; Cytochromes c; Diazoxide; Dopamine; KATP Channels; Membrane Transport Modulators; Mesencephalon; Mice; Mice, Inbred C57BL; Mitochondria; Neurons; Neuroprotective Agents; Neurotoxins; Oxidative Stress; Pinacidil; Potassium Channels, Inwardly Rectifying; Reactive Oxygen Species | 2010 |
New R/S-3,4-dihydro-2,2-dimethyl-2H-1-benzopyrans as K(ATP) channel openers: modulation of the 4-position.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Diazoxide; Islets of Langerhans; Muscle, Smooth, Vascular; Pinacidil; Potassium Channels; Rats; Rats, Wistar; Stereoisomerism; Structure-Activity Relationship; Vasodilator Agents | 2009 |
Interaction of morphine and potassium channel openers on experimental models of pain in mice.
Topics: Animals; Calcium Channel Agonists; Cromakalim; Diazoxide; Drug Interactions; Drug Therapy, Combination; Female; Glyburide; Injections, Intraperitoneal; Male; Mice; Mice, Inbred Strains; Minoxidil; Morphine; Naloxone; Pain; Pain Measurement; Potassium Channels | 2011 |
Potassium channel openers exhibit cross-tolerance with morphine in two experimental models of pain.
Topics: Analgesics, Opioid; Animals; Cromakalim; Diazoxide; Drug Tolerance; Ion Channel Gating; Mice; Minoxidil; Models, Animal; Morphine; Pain; Potassium Channels | 2010 |
Modulation of the 6-position of benzopyran derivatives and inhibitory effects on the insulin releasing process.
Topics: Animals; Aorta; Benzopyrans; Cromakalim; Diazoxide; Insulin; Insulin Secretion; Insulin-Secreting Cells; KATP Channels; Pinacidil; Rats; Structure-Activity Relationship; Vasodilator Agents | 2011 |
K(ATP) channel openers in the trigeminovascular system.
Topics: Animals; ATP-Binding Cassette Transporters; Calcitonin Gene-Related Peptide; Cell Degranulation; Cromakalim; Diazoxide; Disease Models, Animal; Dura Mater; KATP Channels; Male; Mast Cells; Migraine Disorders; Potassium Channels, Inwardly Rectifying; Rats; Rats, Sprague-Dawley; Receptors, Drug; Sulfonylurea Receptors; Trigeminal Caudal Nucleus; Trigeminal Ganglion; Vasodilator Agents | 2012 |
Cholesterol-enriched diet inhibits cardioprotection by ATP-sensitive K+ channel activators cromakalim and diazoxide.
Topics: Adenosine Triphosphate; Animals; Cardiotonic Agents; Cholesterol, Dietary; Cromakalim; Decanoic Acids; Diazoxide; Diet, High-Fat; Glyburide; Hydroxy Acids; In Vitro Techniques; KATP Channels; Lactic Acid; Male; Myocardial Infarction; Oxidative Stress; Potassium Channel Blockers; Rats; Rats, Wistar | 2014 |
Blocking of the ATP sensitive potassium channel ameliorates the ischaemia-reperfusion injury in the rat testis.
Topics: Animals; Apoptosis; Cromakalim; Decanoic Acids; Diazoxide; Glyburide; Hydroxy Acids; KATP Channels; Male; Malondialdehyde; Neutrophil Infiltration; Oxidative Stress; Peroxidase; Potassium Channel Blockers; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Spermatic Cord Torsion; Testis | 2014 |
Effect of ATP-sensitive Potassium Channel Openers on Intraocular Pressure in Ocular Hypertensive Animal Models.
Topics: Animals; Antihypertensive Agents; Cromakalim; Diazoxide; Disease Models, Animal; Eye; Intraocular Pressure; KATP Channels; Mice; Mice, Inbred DBA; Microscopy, Electron, Transmission; Ocular Hypertension; Ophthalmic Solutions | 2022 |
Synthesis of and radioligand binding studies with a tritiated pinacidil analogue: receptor interactions of structurally different classes of potassium channel openers and blockers.
Topics: Animals; Binding Sites; Drug Interactions; Guanidines; Muscle, Smooth, Vascular; Pinacidil; Potassium Channels; Pyridines; Rats; Structure-Activity Relationship; Vasodilator Agents | 1993 |
4,6-Disubstituted 2,2-dimethylchromans structurally related to the K(ATP) channel opener cromakalim: design, synthesis, and effect on insulin release and vascular tone.
Topics: Animals; Aorta, Thoracic; Chromans; Cromakalim; In Vitro Techniques; Insulin; Insulin Secretion; Ion Channel Gating; Islets of Langerhans; Muscle, Smooth, Vascular; Potassium Channels; Rats; Rats, Wistar; Structure-Activity Relationship; Vasodilator Agents | 2005 |
New benzopyran-based openers of the mitochondrial ATP-sensitive potassium channel with potent anti-ischemic properties.
Topics: Adenosine Triphosphate; Animals; Aorta; Benzopyrans; Cardiotonic Agents; Ischemia; L-Lactate Dehydrogenase; Mitochondria, Heart; Myocardial Reperfusion Injury; Potassium Channels; Rats; Vasodilation | 2006 |
Synthesis and activity on rat aorta rings and rat pancreatic beta-cells of ring-opened analogues of benzopyran-type potassium channel activators.
Topics: Animals; Aorta; Benzopyrans; Chromans; Cromakalim; In Vitro Techniques; Insulin; Insulin Antagonists; Insulin Secretion; Insulin-Secreting Cells; Muscle Relaxation; Potassium Channels; Rats; Rats, Wistar | 2008 |
Spirocyclic benzopyran-based derivatives as new anti-ischemic activators of mitochondrial ATP-sensitive potassium channel.
Topics: Animals; Benzopyrans; Blood Pressure; KATP Channels; Male; Mitochondria; Molecular Structure; Myocardial Ischemia; Rats; Rats, Wistar; Spiro Compounds; Structure-Activity Relationship | 2008 |
Enantioselectivity in cardioprotection induced by (S)- (-)-2,2-dimethyl-N-(4'-acetamido-benzyl)-4-spiromorpholone-chromane.
Topics: Animals; Benzopyrans; Cardiotonic Agents; Chromatography, High Pressure Liquid; Circular Dichroism; Crystallography, X-Ray; In Vitro Techniques; Models, Molecular; Molecular Conformation; Myocardial Ischemia; Myocardial Reperfusion; Rats; Spiro Compounds; Stereoisomerism; Structure-Activity Relationship | 2009 |
Predictive models, based on classification algorithms, for compounds potentially active as mitochondrial ATP-sensitive potassium channel openers.
Topics: Algorithms; Benzopyrans; Cardiotonic Agents; KATP Channels; Models, Chemical; Molecular Structure; Quantitative Structure-Activity Relationship; Spiro Compounds | 2009 |
Influence of the alkylsulfonylamino substituent located at the 6-position of 2,2-dimethylchromans structurally related to cromakalim: from potassium channel openers to calcium entry blockers?
Topics: Animals; Aorta; Biological Transport; Calcium; Chromans; Cromakalim; Dose-Response Relationship, Drug; Insulin; Insulin Secretion; Insulin-Secreting Cells; Ion Channel Gating; Muscle Contraction; Potassium Channels; Potassium Chloride; Rats; Stereoisomerism; Structure-Activity Relationship; Sulfur Compounds | 2014 |
4-Phenylureido/thioureido-substituted 2,2-dimethylchroman analogs of cromakalim bearing a bulky 'carbamate' moiety at the 6-position as potent inhibitors of glucose-sensitive insulin secretion.
Topics: Animals; Aorta; Carbamates; Cromakalim; Fura-2; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Rats; Rats, Wistar; Vasodilator Agents | 2016 |