crinane and crinamine
crinane has been researched along with crinamine* in 1 studies
Other Studies
1 other study(ies) available for crinane and crinamine
| Article | Year |
|---|---|
Structure activity studies on the crinane alkaloid apoptosis-inducing pharmacophore.
The apoptosis-inducing ability of alpha-ethano bridged crinane alkaloids was investigated using natural and semi-synthetic derivatives uncovering novel structural requirements of this cytotoxic pharmacophore. An alpha-ethano bridge is required; an alpha- or beta-methoxy or hydroxyl H-bond acceptor are all tolerated at C-3; a small substituent (H, or OH) alone is tolerated at C-11; and a C-1 to C-2 double bond is shown to modulate, but is not a requirement for, apoptosis-inducing activity. Topics: Amaryllidaceae Alkaloids; Apoptosis; Caspase 3; Dose-Response Relationship, Drug; Enzyme Activation; Humans; Hydrogenation; Jurkat Cells; Phenanthridines; Plant Extracts; Structure-Activity Relationship | 2009 |