Page last updated: 2024-08-24

cremophor el and paclitaxel

cremophor el has been researched along with paclitaxel in 126 studies

Research

Studies (126)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	37 (29.37)	18.2507
2000's	52 (41.27)	29.6817
2010's	34 (26.98)	24.3611
2020's	3 (2.38)	2.80

Authors

Authors	Studies
Collins, JM; Jamis-Dow, CA; Katki, AG; Klecker, RW	1
Bergh, J; Brodin, O; Csoka, K; Fridborg, H; Glimelius, B; Hagberg, H; Jonsson, B; Kreuger, A; Nygren, P; Tholander, B	1
Cook, JA; Liebmann, J; Mitchell, JB	1
Cook, JA; Fisher, J; Liebmann, JE; Lipschultz, C; Mitchell, JB; Teague, D	1
Cook, JA; Fisher, J; Liebmann, J; Lipschultz, C; Mitchell, JB; Teague, D	1
Fujimoto, S	1
Dorr, RT	1
Bergh, J; Fjällskog, ML; Frii, L	2
Decker, D; Kessel, D; Sykes, E; Woodburn, K	2
Adler, LM; Herzog, TJ; Mutch, DG; Rader, JS; Williams, S	1
Sharma, A; Straubinger, RM	1
Bishop, J; Linsenmeyer, M; Millward, M; Morton, C; Webster, L; Woodcock, D	1
Boer, HH; Heimans, JJ; Kiburg, B; Moorer-van Delft, CM; Müller, LJ; Vermorken, JB	1
Cosson, EJ; Millward, MJ; Stokes, KH; Webster, LK	1
Beijnen, JH; Nooijen, WJ; Sparreboom, A; van Tellingen, O	1
Csóka, K; Dhar, S; Fridborg, H; Larsson, R; Nygren, P	1
Arnold, H; Bjerkvig, R; Dahl, O; Gundersen, G; Heese, O; Terzis, AJ; Thorsen, F; Visted, T	1
Bonfrer, JM; Hageman, PC; Hilkens, JG; Korse, CM; Linders, TC; Molthoff, CF	1
Beijnen, JH; Huinink, WW; Nuijen, B; Terwogt, JM	1
Brouwer, E; de Bruijn, P; de Vos, AI; Loos, WJ; Nooter, K; Ruijgrok, EJ; Sparreboom, A; Stoter, G; van der Burg, ME; Verweij, J	1
de Vos, AI; Loos, WJ; Nooter, K; Sparreboom, A; Stoter, G; van der Burg, ME; Verweij, J	1
Cordes, N; Fietkau, R; Plasswilm, L; Sauer, R	1
Alving, CR; Muggia, FM; Szebeni, J	1
Locke, DC; Shao, LK	1
Anderson, N; Lokich, J	1
Beijnen, JH; Huizing, MT; Koopmans, FP; Rosing, H	1
Brouwer, E; Hauns, B; Loos, WJ; Mross, K; Nooter, K; Sparreboom, A; Stoter, G; Verweij, J	1
Brouwer, E; de Vos, AI; Gianni, L; Locatelli, A; Loos, WJ; Nooter, K; Sparreboom, A; Stoter, G; van der Burg, ME; Verweij, J; Viganò, L	1
Canada, AL; Ross, HJ; Slater, LM	1
Beijnen, JH; Dubbelman, RC; Hillebrand, MJ; Koopman, FJ; Panday, VR; Rosing, H; Schellens, JH; ten Bokkel Huinink, WW; van Tellingen, O	1
Ellis, AG; Webster, LK	1
Brouwer, E; de Bruijn, P; Gelderblom, H; Loos, WJ; Nooter, K; Pillay, M; Sparreboom, A; Stoter, G; van Zuylen, L; Verweij, J	1
Engblom, P; Grènman, R; Grènman, S; Hirvonen, H; Kulmala, J; Pulkkinen, JO; Rantanen, V	1
Beijnen, JH; Huizing, MT; Nooijen, WJ; Panday, VR; Schellens, JH; van Tellingen, O	1
Brouwer, E; de Bruijn, P; Gelderblom, H; Nooter, K; Pillay, M; Sparreboom, A; Stoter, G; Verweij, J	1
Brouwer, E; Gianni, L; Loos, WJ; Mross, K; Sparreboom, A; van Zuylen, L; Verweij, J	1
Brouwer, E; Buijs, D; De Bruijn, P; Loos, WJ; Pillay, M; Sparreboom, A; Verweij, J	1
Beijnen, JH; Boschma, MU; Giaccone, G; Huizing, MT; Meerum Terwogt, J; Nannan Panday, VR; Schellens, JH; ten Bokkel Huinink, WW; van Tellingen, O; Veenhof, CH	1
Brouwer, E; de Bruijn, P; Karlsson, MO; Nooter, K; Sparreboom, A; Stoter, G; van Zuylen, L; Verweij, J	1
Alving, CR; Barenholz, Y; Danino, D; Priev, A; Savay, S; Szebeni, J; Talmon, Y	1
Sparreboom, A; van Zuylen, L; Verweij, J	1
Gianni, L; Grasselli, G; Locatelli, A; Vigano, L	1
Gianni, L; Henningsson, A; Karlsson, MO; Sparreboom, A; Verweij, J; Viganò, L	1
Bardelmeijer, HA; Beijnen, JH; Koopman, FJ; Malingré, MM; Ouwehand, M; Rosing, H; Schellens, JH; Schot, ME; Ten Bokkel Huinink, WW; Van Tellingen, O	1
Behringer, D; Gelderblom, H; Mielke, S; Mross, K; Sparreboom, A; ten Tije, AJ; van Zomeren, DM; Verweij, J	1
Bardelmeijer, HA; Beijnen, JH; Malingré, MM; Ouwehand, M; Schellens, J; van Tellingen, O	1
Buijs, D; Gelderblom, H; Nooter, K; Ouwens, L; Sparreboom, A; Stoter, G; van Zomeren, DM; Verweij, J	1
Baldini, E; Bocci, G; Conte, PF; Danesi, R; Del Tacca, M; Di Paolo, A; Fogli, S; Gennari, A; Innocenti, F; Salvadori, B	1
Briasoulis, E; Haidou, C; Karavasilis, V; Pavlidis, N; Piperidou, C; Tzamakou, E	1
Barboza, R; Coradi, ST; Covolan, CC; Maranhão, RC; Rodrigues, DG	1
Beijnen, JH; Mathôt, RA; Schellens, JH; van den Bongard, HJ; van Tellingen, O	1
Audus, KL; Borchardt, RT; Burton, PS; Hugger, ED; Novak, BL	1
Balcerzak, S; Chan, KK; D'Ambrosio, S; Grever, M; Kraut, EH; Liu, J	1
He, L; Wang, GL; Zhang, Q	1
Beijnen, JH; Boogerd, W; Cleypool, C; Kemper, EM; Mos, HA; van Tellingen, O; van Zandbergen, AE	1
Chen, H; Ellis, SJ; Heimlich, K; Kim, SC; Lee, JW; Lemmo, AV; McNulty, C; Oh, HS; Olbert, C; Seo, MH; Yoon, HJ; Zhang, Z	1
De Giorgi, U; Frassineti, GL; Marangolo, M; Monti, M; Rosti, G	1
Beijnen, JH; Kemper, EM; Mathôt, RA; Rosing, H; Schellens, JH; van den Bongard, HJ; van Tellingen, O	1
Figg, WD; Ng, SS; Sparreboom, A	1
Cho, MC; Kim, DW; Kim, MS; Kim, YG; Kwon, JS; Lee, GS; Youn, TJ	1
Badea, I; Ciutaru, D; Lazara, L; Nicolescu, D; Tudose, A	1
Furui, N; Furukawa, H; Fushida, S; Ishizaki, J; Jin, M; Miwa, K; Miyamoto, K; Nomura, M; Yamazaki, M; Yokogawa, K; Yoshihara, H	1
Bikram, M; Furgeson, DY; Janát-Amsbury, MM; Kern, S; Kim, SW; Lee, M; Yockman, JW	1
Allen, DD; Koziara, JM; Lockman, PR; Mumper, RJ	1
Ahmad, I; Anyarambhatla, G; Ma, L; Sardone, T; Ugwu, S; Xuan, T; Zhang, JA	1
Beijnen, JH; de Jonge, ME; Huitema, AD; Rodenhuis, S; Schellens, JH	1
Figg, WD; Loos, WJ; Scripture, CD; Sparreboom, A; Szebeni, J	1
Lim, LY; Mo, Y	1
Dhanikula, AB; Panchagnula, R; Singh, DR	1
Feng, SS; Win, KY	1
DeVido, DR; Perdue, JD; Seaton, PJ; Tyrell, JA	1
Choi, K; Chung, H; Jeong, SY; Kim, IS; Kim, JH; Kim, K; Kim, S; Kim, YS; Kwon, IC; Park, JH; Park, RW	1
Gradishar, WJ	1
Keating, GM; Robinson, DM	1
Davidson, N; Harper, P; Harries, M; Ibrahim, N	1
Chu, ZE; Figg, WD; Gardner, ER; Liau, CT; Sparreboom, A	1
Höke, A; Jack, C; Lambrinos, GL; Melli, G; Ringkamp, M	1
Allen, C; De Souza, R; Grant, J; Piquette-Miller, M; Vassileva, V	1
Chang, DH; Kim, BO; Kim, SO; Lee, SW; Seo, MH; Shim, MS	1
Pishko, MV; Zahr, AS	1
Chitkara, D; Kumar, N; Mittal, A	1
Fransson, M; Gréen, H	1
Chen, JS; Chen, PM; Chu, Z; Figg, WD; Gardner, ER; Liau, CT; Lin, YC; Sparreboom, A; Wang, HM; Yang, MH	1
Chang, YW; Chao, YS; Chen, CT; Chiang, TH; Ho, PY; Lin, HL; Lo, YK; Wu, HY; Wu, SH; Yao, HT; Yeh, TK	1
Agharkar, SN; Gogate, US; Schwartz, PA	1
Danhier, F; Feron, O; Jérôme, C; Lecouturier, N; Marchand-Brynaert, J; Préat, V; Vroman, B	1
Ito, C; Kamijo, Y; Miyamoto, K; Nomura, M; Sai, Y	1
Kossoff, E; O'Connor, TL	1
Tang, C; Wu, L; Yin, C	1
Harrold, JM; Mager, DE; Mazurchuk, RV; Straubinger, RM; Tamburlin, JH; Zhou, R	1
Huo, M; Li, H; Li, J; Wu, Y; Yu, D; Zhang, Y; Zhou, J; Zou, A	1
Bathula, SR; Conwell, C; Huang, L; Liu, F; Liu, Y; Park, JY; Zhang, Y	1
Fransson, MN; Friberg, LE; Gréen, H; Litton, JE	1
Burt, H; Jackson, J; Tsallas, A	1
Chen, S; Nie, SF; Pan, WS; Wang, X; Wang, Y; Wu, KC; Zhang, Q; Zhang, X; Zhao, BX; Zhao, X	1
Chi, SC; Choi, HG; Hwang, DH; Lyoo, WS; Park, JH; Shanmugam, S; Woo, JS; Yan, YD; Yong, CS	1
Jain, S; Tiwary, AK; Utreja, P	2
Cao, W; He, Z; Li, X; Lian, H; Liu, Y; Sun, J; Sun, Y; Wang, S; Wang, Y; Yang, J	1
Czúcz, J; Révész, C; Rosivall, L; Rozsnyay, Z; Szebeni, J; Weiszhár, Z	1
Chen, L; Deng, Y; Gao, Y; Ji, X; Li, Y; Zhang, Z	1
Bushman, J; Garbuzenko, OB; Gounder, MK; Kohn, J; Minko, T; Sheihet, L	1
Jain, S; Khandhuja, KL; Tiwary, AK; Utreja, P; Yadav, S	1
Emoto, S; Ishigami, H; Kishikawa, J; Kitayama, J; Yamaguchi, H; Yamashita, H	1
Chen, X; Liu, X; Scott, H; Sun, J; Wang, S; Zhang, Q; Zhang, X	1
Andringa, G; Egberts, AC; Fens, MH; Gaillard, CA; Rasmussen, JT; Sachini, N; Schiffelers, RM; Vader, P; van Oirschot, BA; van Solinge, WW; van Wijk, R	1
Jain, SK; Kumar, N; Mahajan, M; Roy, P; Tiwary, AK; Utreja, P	1
Campos, FC; Cecchini, AL; Cecchini, R; Martins-Pinge, MC; Panis, C; Victorino, VJ	1
Lansky, AJ; Mena, C; Ng, VG; Pietras, C	1
Chen, N; Li, Y; Palmisano, M; Zhou, S	1
Catalano, P; Colby, A; Colson, YL; Grinstaff, MW; Hofferberth, SC; Lei, H; Liu, R; Tevis, KM	1
Clogston, JD; Dobrovolskaia, MA; Ilinskaya, AN; McNeil, SE	1
Ajorlou, E; Khosroushahi, AY; Yeganeh, H	1
Ding, R; Fu, Y; Gong, T; Li, H; Luo, J; Zhang, T; Zhang, Z	1
Al-Najjar, BY; Alhnan, MA; El Nemr, S; Elhissi, AMA; Omer, HK	1
Chowdhury, MR; Goto, M; Kamiya, N; Moniruzzaman, M; Moshikur, RM; Tahara, Y; Wakabayashi, R	2
Cui, F; Gong, X; Li, Q; Liang, N; Sun, S; Yan, P	1
Chen, YH; Huang, ST; Li, WS; Lin, CT; Wang, YP; Wu, HC	1
Ajmal, G; Bonde, GV; Kapoor, R; Mishra, B; Mittal, A; Mittal, P; Vardhan, H	1
Aserin, A; Ezrahi, S; Garti, N	1
Chen, T; Dalvi, P; Harper, PA; Hino, H; Ito, S; Sun, L; Yang, M	1
Arcangeli, M; Baldari, B; D'Errico, S; Fineschi, V; Frati, P; Santurro, A	1
Fan, G; Fei, Y; Shen, F; Wang, Y; Wu, S	1

Reviews

7 review(s) available for cremophor el and paclitaxel

Article	Year
Pharmacology and toxicology of Cremophor EL diluent. The Annals of pharmacotherapy, 1994, Volume: 28, Issue:5 Suppl Topics: Animals; Drug Hypersensitivity; Glycerol; Humans; Paclitaxel; Pharmaceutical Vehicles; Solvents; Surface-Active Agents	1994
Alternative formulations of paclitaxel. Cancer treatment reviews, 1997, Volume: 23, Issue:2 Topics: Antineoplastic Agents, Phytogenic; Chemistry, Pharmaceutical; Drug Carriers; Emulsions; Glycerol; Humans; Infusions, Intravenous; Liposomes; Paclitaxel; Prodrugs; Solvents	1997
Role of formulation vehicles in taxane pharmacology. Investigational new drugs, 2001, Volume: 19, Issue:2 Topics: Animals; Anthracyclines; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chemistry, Pharmaceutical; Cyclosporine; Drug Hypersensitivity; Drug Resistance, Multiple; Glycerol; Humans; Micelles; Neoplasms; Nervous System Diseases; Paclitaxel; Polysorbates; Surface-Active Agents	2001
Drug interactions of paclitaxel and docetaxel and their relevance for the design of combination therapy. Investigational new drugs, 2001, Volume: 19, Issue:2 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Chemistry, Pharmaceutical; Cisplatin; Docetaxel; Drug Administration Schedule; Drug Interactions; Glycerol; Humans; Neoplasms; Paclitaxel; Pharmaceutical Vehicles; Radiotherapy, Adjuvant; Taxoids; Vinca Alkaloids	2001
Albumin-bound paclitaxel: a next-generation taxane. Expert opinion on pharmacotherapy, 2006, Volume: 7, Issue:8 Topics: Albumin-Bound Paclitaxel; Albumins; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Chemistry, Pharmaceutical; Drug Administration Schedule; Drug Delivery Systems; Endothelial Cells; Female; Glycerol; Humans; Infusions, Intra-Arterial; Nanotechnology; Neoplasm Metastasis; Osteonectin; Paclitaxel; Randomized Controlled Trials as Topic; Solvents; Survival Rate; Therapeutic Equivalency	2006
Local delivery of paclitaxel in the treatment of peripheral arterial disease. European journal of clinical investigation, 2015, Volume: 45, Issue:3 Topics: Angioplasty, Balloon; Clinical Trials as Topic; Drug Evaluation, Preclinical; Drug-Eluting Stents; Glycerol; Humans; Infusions, Intravenous; Iohexol; Nanoparticles; Paclitaxel; Peripheral Arterial Disease; Pharmaceutical Vehicles; Tubulin Modulators	2015
Basic principles of drug delivery systems - the case of paclitaxel. Advances in colloid and interface science, 2019, Volume: 263 Topics: Antineoplastic Agents, Phytogenic; Biological Availability; Biological Transport; Drug Delivery Systems; Drug Stability; Emulsions; Glycerol; Humans; Microtubules; Mitosis; Nanostructures; Neoplasms; Paclitaxel; Solubility; Solvents; Tumor Cells, Cultured	2019

Trials

12 trial(s) available for cremophor el and paclitaxel

Article	Year
Phase I and pharmacologic study of weekly doxorubicin and 1 h infusional paclitaxel in patients with advanced breast cancer. Anti-cancer drugs, 1998, Volume: 9, Issue:8 Topics: Adult; Alopecia; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Dose-Response Relationship, Drug; Doxorubicin; Drug Administration Schedule; Female; Glycerol; Humans; Infusions, Intravenous; Middle Aged; Neutropenia; Paclitaxel	1998
Inter-relationships of paclitaxel disposition, infusion duration and cremophor EL kinetics in cancer patients. Anti-cancer drugs, 2000, Volume: 11, Issue:5 Topics: Antineoplastic Agents, Phytogenic; Glycerol; Humans; Infusions, Intravenous; Neoplasms; Paclitaxel; Surface-Active Agents	2000
Measurement of fraction unbound paclitaxel in human plasma. Drug metabolism and disposition: the biological fate of chemicals, 2000, Volume: 28, Issue:10 Topics: Antineoplastic Agents, Phytogenic; Binding, Competitive; Dose-Response Relationship, Drug; Female; Glycerol; Humans; Male; Metabolic Clearance Rate; Middle Aged; Paclitaxel; Plasma	2000
Cremophor EL pharmacokinetics in a phase I study of paclitaxel (Taxol) and carboplatin in non-small cell lung cancer patients. Anti-cancer drugs, 2000, Volume: 11, Issue:9 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Carboplatin; Carcinoma, Non-Small-Cell Lung; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Glycerol; Humans; Lung Neoplasms; Male; Middle Aged; Paclitaxel; Pharmaceutical Vehicles	2000
Pharmacokinetic modeling of paclitaxel encapsulation in Cremophor EL micelles. Cancer chemotherapy and pharmacology, 2001, Volume: 47, Issue:4 Topics: Adult; Antineoplastic Agents, Phytogenic; Area Under Curve; Blood Proteins; Excipients; Female; Glycerol; Half-Life; Humans; Male; Micelles; Middle Aged; Models, Biological; Paclitaxel; Protein Binding	2001
Mechanism-based pharmacokinetic model for paclitaxel. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001, Oct-15, Volume: 19, Issue:20 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Doxorubicin; Female; Glycerol; Humans; Infusions, Intravenous; Male; Mathematics; Middle Aged; Neutropenia; Paclitaxel; Solvents	2001
The co-solvent Cremophor EL limits absorption of orally administered paclitaxel in cancer patients. British journal of cancer, 2001, Nov-16, Volume: 85, Issue:10 Topics: Administration, Oral; Antineoplastic Agents, Phytogenic; Area Under Curve; Cyclosporine; Drug Combinations; Feces; Glycerol; Humans; Intestinal Absorption; Neoplasms; Paclitaxel; Pharmaceutical Vehicles; Polysorbates; Solvents	2001
Comparative pharmacokinetics of unbound paclitaxel during 1- and 3-hour infusions. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002, Jan-15, Volume: 20, Issue:2 Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Area Under Curve; Drug Administration Schedule; Female; Glycerol; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasms; Neutropenia; Paclitaxel; Surface-Active Agents; Thrombocytopenia; Time Factors	2002
Influence of Cremophor El on the bioavailability of intraperitoneal paclitaxel. Clinical cancer research : an official journal of the American Association for Cancer Research, 2002, Volume: 8, Issue:4 Topics: Aged; Antineoplastic Agents, Phytogenic; Ascitic Fluid; Biological Availability; Female; Gastrointestinal Diseases; Glycerol; Hematologic Diseases; Humans; Injections, Intraperitoneal; Injections, Intravenous; Mesothelioma; Middle Aged; Ovarian Neoplasms; Paclitaxel	2002
Pharmacokinetics and pharmacodynamics of combination chemotherapy with paclitaxel and epirubicin in breast cancer patients. British journal of clinical pharmacology, 2002, Volume: 53, Issue:5 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Doxorubicin; Drug Administration Schedule; Drug Interactions; Epirubicin; Female; Glycerol; Humans; In Vitro Techniques; Infusions, Intravenous; Middle Aged; Paclitaxel	2002
Comparison of two types of population pharmacokinetic model structures of paclitaxel. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2008, Feb-05, Volume: 33, Issue:2 Topics: Adult; Aged; Algorithms; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Carboplatin; Computer Simulation; Female; Genital Neoplasms, Female; Glycerol; Humans; Middle Aged; Models, Biological; Paclitaxel; Pharmaceutical Vehicles; Reproducibility of Results	2008
Oral bioavailability of a novel paclitaxel formulation (Genetaxyl) administered with cyclosporin A in cancer patients. Anti-cancer drugs, 2008, Volume: 19, Issue:3 Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents, Phytogenic; Area Under Curve; Biological Availability; Cyclosporine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Glycerol; Humans; Immunosuppressive Agents; Infusions, Intravenous; Male; Middle Aged; Neoplasms; Paclitaxel	2008

Other Studies

107 other study(ies) available for cremophor el and paclitaxel

Article	Year
Metabolism of taxol by human and rat liver in vitro: a screen for drug interactions and interspecies differences. Cancer chemotherapy and pharmacology, 1995, Volume: 36, Issue:2 Topics: Animals; Biotransformation; Cimetidine; Cytochrome P-450 Enzyme System; Dexamethasone; Diphenhydramine; Drug Evaluation, Preclinical; Drug Interactions; Glycerol; Humans; In Vitro Techniques; Ketoconazole; Kinetics; Liver; Microsomes, Liver; Paclitaxel; Quinidine; Rats; Species Specificity; Surface-Active Agents; Taxoids; Tritium	1995
The cytotoxic activity of Taxol in primary cultures of tumour cells from patients is partly mediated by Cremophor EL. British journal of cancer, 1995, Volume: 71, Issue:3 Topics: Antineoplastic Agents; Drug Screening Assays, Antitumor; Drug Synergism; Fluorometry; Glycerol; Humans; Kinetics; Neoplasms; Paclitaxel; Solvents; Tumor Cells, Cultured	1995
Cremophor EL, solvent for paclitaxel, and toxicity. Lancet (London, England), 1993, Dec-04, Volume: 342, Issue:8884 Topics: Adenocarcinoma; Cell Division; Glycerol; Humans; Paclitaxel; Solvents; Tumor Cells, Cultured	1993
Cytotoxic studies of paclitaxel (Taxol) in human tumour cell lines. British journal of cancer, 1993, Volume: 68, Issue:6 Topics: Adenocarcinoma; Astrocytoma; Breast Neoplasms; Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Drug; Female; Glycerol; HeLa Cells; Humans; Lung Neoplasms; Ovarian Neoplasms; Paclitaxel; Pancreatic Neoplasms; Tumor Cells, Cultured; Uterine Cervical Neoplasms	1993
The influence of Cremophor EL on the cell cycle effects of paclitaxel (Taxol) in human tumor cell lines. Cancer chemotherapy and pharmacology, 1994, Volume: 33, Issue:4 Topics: Adenocarcinoma; Breast Neoplasms; Cell Cycle; DNA, Neoplasm; Female; Flow Cytometry; Glycerol; Humans; Lung Neoplasms; Mitotic Index; Paclitaxel; Pharmaceutical Vehicles; Photography; Tumor Cells, Cultured	1994
[Study for modifying activity of solvents on antitumor activity of paclitaxel]. Gan to kagaku ryoho. Cancer & chemotherapy, 1994, Volume: 21, Issue:5 Topics: Animals; Cell Division; Dimethyl Sulfoxide; Doxorubicin; Drug Resistance; Glycerol; Leukemia P388; Male; Mice; Paclitaxel; Solvents; Tumor Cells, Cultured; Vincristine	1994
Paclitaxel-induced cytotoxicity--the effects of cremophor EL (castor oil) on two human breast cancer cell lines with acquired multidrug resistant phenotype and induced expression of the permeability glycoprotein. European journal of cancer (Oxford, England : 1990), 1994, Volume: 30A, Issue:5 Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Carrier Proteins; Cell Survival; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance; Drug Screening Assays, Antitumor; Drug Synergism; Ethanol; Female; Glycerol; Humans; Membrane Glycoproteins; Neoplasm Proteins; Paclitaxel; Phenotype; Solvents; Tumor Cells, Cultured	1994
Effects of Cremophor EL on distribution of Taxol to serum lipoproteins. British journal of cancer, 1994, Volume: 70, Issue:3 Topics: Centrifugation, Density Gradient; Drug Interactions; Electrophoresis; Glycerol; Humans; Infusions, Intravenous; Lipoproteins, HDL; Lipoproteins, LDL; Paclitaxel; Pharmaceutical Vehicles; Protein Binding; Serum Albumin; Solvents; Tissue Distribution; Ultracentrifugation	1994
Analysis of exposure times and dose escalation of paclitaxel in ovarian cancer cell lines. Cancer, 1994, Oct-01, Volume: 74, Issue:7 Topics: Cell Cycle; Cell Division; Dimethyl Sulfoxide; Drug Carriers; Drug Screening Assays, Antitumor; Female; Glycerol; Humans; Ovarian Neoplasms; Paclitaxel; Time Factors; Tumor Cells, Cultured	1994
Novel taxol formulations: preparation and characterization of taxol-containing liposomes. Pharmaceutical research, 1994, Volume: 11, Issue:6 Topics: Animals; Cell Division; Cell Line; Drug Carriers; Drug Stability; Drug Storage; Electrochemistry; Female; Glycerol; Humans; Liposomes; Mice; Mice, Inbred BALB C; Paclitaxel; Pharmaceutical Vehicles; Phosphatidylcholines; Phosphatidylglycerols	1994
Is Cremophor EL, solvent for paclitaxel, cytotoxic? Lancet (London, England), 1993, Oct-02, Volume: 342, Issue:8875 Topics: Breast Neoplasms; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance; Glycerol; Humans; Paclitaxel; Solvents; Tumor Cells, Cultured	1993
Measurement of cremophor EL following taxol: plasma levels sufficient to reverse drug exclusion mediated by the multidrug-resistant phenotype. Journal of the National Cancer Institute, 1993, Oct-20, Volume: 85, Issue:20 Topics: Adult; Aged; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Assay; Carrier Proteins; Drug Resistance; Female; Flow Cytometry; Glycerol; Humans; Membrane Glycoproteins; Middle Aged; Neoplasm Proteins; Ovarian Neoplasms; Paclitaxel; Pharmaceutical Vehicles; Phenotype; Tumor Cells, Cultured	1993
Ultrastructural neuropathologic effects of Taxol on neurons of the freshwater snail Lymnaea stagnalis. Journal of neuro-oncology, 1995, Volume: 25, Issue:1 Topics: Adrenocorticotropic Hormone; Animals; Anticonvulsants; Antineoplastic Agents, Phytogenic; Axons; Ganglia, Invertebrate; Glycerol; In Vitro Techniques; Lymnaea; Microscopy, Electron; Microtubules; Neurons; Paclitaxel; Peptide Fragments; Pharmaceutical Vehicles	1995
Fractionation of Cremophor EL delineates components responsible for plasma lipoprotein alterations and multidrug resistance reversal. Oncology research, 1995, Volume: 7, Issue:5 Topics: Animals; Antineoplastic Agents; Biological Transport; Chemical Fractionation; Chromatography, High Pressure Liquid; Daunorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Electrophoresis, Agar Gel; Electrophoresis, Polyacrylamide Gel; Glycerol; Humans; Leukemia P388; Lipoproteins; Mice; Paclitaxel; Pharmaceutical Vehicles; Protein Binding	1995
Effect of the paclitaxel vehicle, Cremophor EL, on the pharmacokinetics of doxorubicin and doxorubicinol in mice. British journal of cancer, 1996, Volume: 73, Issue:4 Topics: Animals; Antibiotics, Antineoplastic; Doxorubicin; Female; Glycerol; Metabolic Clearance Rate; Mice; Mice, Inbred BALB C; Paclitaxel; Solvents; Time Factors	1996
Nonlinear pharmacokinetics of paclitaxel in mice results from the pharmaceutical vehicle Cremophor EL. Cancer research, 1996, May-01, Volume: 56, Issue:9 Topics: Animals; Antineoplastic Agents, Phytogenic; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Female; Glycerol; Humans; Mice; Paclitaxel; Pharmaceutical Vehicles; Solvents	1996
Differential activity of Cremophor EL and paclitaxel in patients' tumor cells and human carcinoma cell lines in vitro. Cancer, 1997, Mar-15, Volume: 79, Issue:6 Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Glycerol; Humans; Paclitaxel; Surface-Active Agents; Tumor Cells, Cultured	1997
Proliferation, migration and invasion of human glioma cells exposed to paclitaxel (Taxol) in vitro. British journal of cancer, 1997, Volume: 75, Issue:12 Topics: Adult; Animals; Antineoplastic Agents, Phytogenic; Brain Neoplasms; Cell Division; Cell Movement; Female; Flow Cytometry; Glioblastoma; Glioma; Glycerol; Humans; Microscopy, Confocal; Paclitaxel; Rats; Rats, Wistar; Solvents; Spheroids, Cellular; Tumor Cells, Cultured	1997
Effect of paclitaxel (Taxol) on CA 125 expression and release by ovarian cancer cell lines. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 1997, Volume: 18, Issue:4 Topics: Antineoplastic Agents, Phytogenic; CA-125 Antigen; Cell Count; Cystadenocarcinoma, Serous; Female; Glycerol; Humans; Immunohistochemistry; Ovarian Neoplasms; Paclitaxel; Pharmaceutical Vehicles; Tumor Cells, Cultured	1997
Differential modulation of cisplatin accumulation in leukocytes and tumor cell lines by the paclitaxel vehicle Cremophor EL. Annals of oncology : official journal of the European Society for Medical Oncology, 1997, Volume: 8, Issue:11 Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Cisplatin; Drug Interactions; Glycerol; Humans; In Vitro Techniques; Leukocytes; Paclitaxel; Pharmaceutical Vehicles; Polyethylene Glycols; Polysorbates; Surface-Active Agents	1997
Quantitation of Cremophor EL in human plasma samples using a colorimetric dye-binding microassay. Analytical biochemistry, 1998, Jan-15, Volume: 255, Issue:2 Topics: Antineoplastic Agents, Phytogenic; Calibration; Colorimetry; Coloring Agents; Female; Glycerol; Humans; Ovarian Neoplasms; Paclitaxel; Pilot Projects; Reproducibility of Results; Rosaniline Dyes; Surface-Active Agents	1998
Cytotoxicity of fractionated paclitaxel (Taxol) administration in vitro. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 1998, Volume: 174, Issue:1 Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line; Cell Survival; Cells, Cultured; Cricetinae; Cricetulus; DNA; Dose-Response Relationship, Drug; Ethanol; Flow Cytometry; Glycerol; Paclitaxel; Solvents; Time Factors	1998
Complement activation by Cremophor EL as a possible contributor to hypersensitivity to paclitaxel: an in vitro study. Journal of the National Cancer Institute, 1998, Feb-18, Volume: 90, Issue:4 Topics: Antineoplastic Agents, Phytogenic; Complement Activation; Drug Hypersensitivity; Enzyme-Linked Immunosorbent Assay; Glycerol; Humans; In Vitro Techniques; Paclitaxel; Pharmaceutical Vehicles	1998
Separation of paclitaxel and related taxanes by micellar electrokinetic capillary chromatography. Analytical chemistry, 1998, Mar-01, Volume: 70, Issue:5 Topics: Acetonitriles; Chromatography; Glycerol; Micelles; Paclitaxel; Plant Extracts; Sodium Dodecyl Sulfate; Temperature; Thermodynamics	1998
Paclitaxel hypersensitivity reactions: a role for docetaxel substitution. Annals of oncology : official journal of the European Society for Medical Oncology, 1998, Volume: 9, Issue:5 Topics: Aged; Antineoplastic Agents, Phytogenic; Docetaxel; Drug Hypersensitivity; Female; Glycerol; Humans; Male; Middle Aged; Neoplasms; Paclitaxel; Taxoids	1998
Influence of Cremophor EL on the quantification of paclitaxel in plasma using high-performance liquid chromatography with solid-phase extraction as sample pretreatment. Journal of chromatography. B, Biomedical sciences and applications, 1998, May-08, Volume: 709, Issue:1 Topics: Antineoplastic Agents, Phytogenic; Chromatography, High Pressure Liquid; Evaluation Studies as Topic; Glycerol; Humans; Paclitaxel; Pharmaceutical Vehicles	1998
Linearized colorimetric assay for cremophor EL: application to pharmacokinetics after 1-hour paclitaxel infusions. Analytical biochemistry, 1998, Aug-01, Volume: 261, Issue:2 Topics: Antineoplastic Agents, Phytogenic; Colorimetry; Glycerol; Humans; Paclitaxel; Pharmaceutical Vehicles; Reproducibility of Results	1998
Disposition of Cremophor EL in humans limits the potential for modulation of the multidrug resistance phenotype in vivo. Clinical cancer research : an official journal of the American Association for Cancer Research, 1998, Volume: 4, Issue:8 Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Body Fluid Compartments; Cisplatin; Clinical Trials, Phase I as Topic; Doxorubicin; Drug Resistance, Multiple; Female; Glycerol; Humans; Infusions, Intravenous; Middle Aged; Neoplasms; Paclitaxel; Phenotype; Surface-Active Agents; Tissue Distribution	1998
Cyclosporin A enhances paclitaxel toxicity against leukemia and respiratory epithelial cancers. Clinical cancer research : an official journal of the American Association for Cancer Research, 1997, Volume: 3, Issue:1 Topics: Animals; Antineoplastic Agents, Phytogenic; Cyclosporine; Cytokines; Disease Models, Animal; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Glycerol; Growth Substances; Humans; Immunosuppressive Agents; Leukemia; Mice; Paclitaxel; Respiratory Tract Neoplasms; Survival Rate; Treatment Outcome; Tumor Cells, Cultured	1997
Inhibition of paclitaxel elimination in the isolated perfused rat liver by Cremophor EL. Cancer chemotherapy and pharmacology, 1999, Volume: 43, Issue:1 Topics: Animals; Antineoplastic Agents, Phytogenic; Area Under Curve; Bile; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Glycerol; Half-Life; In Vitro Techniques; Liver; Male; Paclitaxel; Rats; Rats, Sprague-Dawley; Surface-Active Agents	1999
Cremophor EL-mediated alteration of paclitaxel distribution in human blood: clinical pharmacokinetic implications. Cancer research, 1999, Apr-01, Volume: 59, Issue:7 Topics: Aged; Antineoplastic Agents, Phytogenic; Erythrocytes; Female; Glycerol; Humans; Micelles; Paclitaxel; Pharmaceutical Vehicles	1999
Effects of paclitaxel with or without cremophor EL on cellular clonogenic survival and apoptosis. European journal of cancer (Oxford, England : 1990), 1999, Volume: 35, Issue:2 Topics: Adenocarcinoma; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Squamous Cell; Cell Survival; Glycerol; Humans; Paclitaxel; Pharmaceutical Vehicles; Tumor Cells, Cultured; Tumor Stem Cell Assay	1999
Cremophor EL causes (pseudo-) non-linear pharmacokinetics of paclitaxel in patients. British journal of cancer, 1999, Volume: 81, Issue:2 Topics: Area Under Curve; Dialysis; Glycerol; Humans; Paclitaxel; Pharmaceutical Vehicles; Surface-Active Agents	1999
Disposition of [G-(3)H]paclitaxel and cremophor EL in a patient with severely impaired renal function. Drug metabolism and disposition: the biological fate of chemicals, 1999, Volume: 27, Issue:11 Topics: Aged; Antineoplastic Agents, Phytogenic; Chromatography, High Pressure Liquid; Female; Glycerol; Humans; Nephrosclerosis; Ovarian Neoplasms; Paclitaxel; Spectrophotometry, Ultraviolet	1999
Formation of complement-activating particles in aqueous solutions of Taxol: possible role in hypersensitivity reactions. International immunopharmacology, 2001, Volume: 1, Issue:4 Topics: Antineoplastic Agents, Phytogenic; Complement Activation; Complement Membrane Attack Complex; Drug Hypersensitivity; Glycerol; Humans; Immunoglobulins, Intravenous; Micelles; Paclitaxel; Solutions	2001
Entrapment by Cremophor EL decreases the absorption of paclitaxel from the gut. Cancer chemotherapy and pharmacology, 2002, Volume: 49, Issue:2 Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Female; Glycerol; Intestinal Absorption; Mice; Micelles; Paclitaxel	2002
Pharmacodynamics of non-break weekly paclitaxel (Taxol) and pharmacokinetics of Cremophor-EL vehicle: results of a dose-escalation study. Anti-cancer drugs, 2002, Volume: 13, Issue:5 Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Area Under Curve; Dose-Response Relationship, Drug; Female; Glycerol; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Neutropenia; Paclitaxel; Pharmaceutical Vehicles; Surface-Active Agents	2002
Use of a cholesterol-rich emulsion that binds to low-density lipoprotein receptors as a vehicle for paclitaxel. The Journal of pharmacy and pharmacology, 2002, Volume: 54, Issue:6 Topics: Animals; Antineoplastic Agents; Cell Division; Cholesterol; Drug Carriers; Drug Stability; Emulsions; Glycerol; Lethal Dose 50; Paclitaxel; Particle Size; Rats; Rats, Wistar; Receptors, LDL; Tumor Cells, Cultured	2002
A population analysis of the pharmacokinetics of Cremophor EL using nonlinear mixed-effect modelling. Cancer chemotherapy and pharmacology, 2002, Volume: 50, Issue:1 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Carboplatin; Female; Glycerol; Humans; Infusions, Intravenous; Male; Middle Aged; Models, Biological; Neoplasms; Paclitaxel; Pharmaceutical Vehicles; Surface-Active Agents	2002
A comparison of commonly used polyethoxylated pharmaceutical excipients on their ability to inhibit P-glycoprotein activity in vitro. Journal of pharmaceutical sciences, 2002, Volume: 91, Issue:9 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Carbon Radioisotopes; Cell Line; Dogs; Excipients; Glycerol; Humans; Mannitol; Membrane Fluidity; Paclitaxel; Polyethylene Glycols; Polysorbates; Tritium	2002
Dosing sequence-dependent pharmacokinetic interaction of oxaliplatin with paclitaxel in the rat. Cancer chemotherapy and pharmacology, 2002, Volume: 50, Issue:6 Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Area Under Curve; Biological Availability; Chromatography, High Pressure Liquid; Drug Interactions; Glycerol; In Vitro Techniques; Infusions, Intravenous; Leukocytes; Male; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Rats; Rats, Sprague-Dawley; Tissue Distribution	2002
An alternative paclitaxel microemulsion formulation: hypersensitivity evaluation and pharmacokinetic profile. International journal of pharmaceutics, 2003, Jan-02, Volume: 250, Issue:1 Topics: Animals; Antineoplastic Agents, Phytogenic; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Drug Hypersensitivity; Emulsions; Female; Glycerol; Guinea Pigs; Male; Paclitaxel	2003
Increased penetration of paclitaxel into the brain by inhibition of P-Glycoprotein. Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Volume: 9, Issue:7 Topics: Acridines; Animals; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Chromatography, High Pressure Liquid; Clinical Trials as Topic; Cyclosporine; Cyclosporins; Dose-Response Relationship, Drug; Female; Glycerol; Mice; Mice, Knockout; Paclitaxel; Tetrahydroisoquinolines; Time Factors	2003
A high-throughput combinatorial approach for the discovery of a cremophor EL-free paclitaxel formulation. Pharmaceutical research, 2003, Volume: 20, Issue:8 Topics: Animals; Chemistry, Pharmaceutical; Combinatorial Chemistry Techniques; Dose-Response Relationship, Drug; Drug Compounding; Excipients; Glycerol; Male; Paclitaxel; Rats; Rats, Sprague-Dawley; Time Factors	2003
Onycholysis secondary to multiple paclitaxel 1-hour infusions: possible role for its vehicle (Cremophor EL). Annals of oncology : official journal of the European Society for Medical Oncology, 2003, Volume: 14, Issue:10 Topics: Antineoplastic Agents, Phytogenic; Area Under Curve; Breast Neoplasms; Drug Administration Schedule; Female; Glycerol; Humans; Infusions, Intravenous; Nail Diseases; Paclitaxel; Pharmaceutical Vehicles; Solvents; Surface-Active Agents	2003
Development and validation of a method to determine the unbound paclitaxel fraction in human plasma. Analytical biochemistry, 2004, Jan-01, Volume: 324, Issue:1 Topics: Aged; Antineoplastic Agents, Phytogenic; Carbon Radioisotopes; Countercurrent Distribution; Glycerol; Hemofiltration; Humans; Male; Micelles; Paclitaxel; Protein Binding; Reproducibility of Results; Scintillation Counting; Serum Albumin; Solvents; Time Factors; Tritium	2004
Taxane-mediated antiangiogenesis in vitro: influence of formulation vehicles and binding proteins. Cancer research, 2004, Feb-01, Volume: 64, Issue:3 Topics: Angiogenesis Inhibitors; Animals; Aorta, Thoracic; Blood Proteins; Cell Division; Chemistry, Pharmaceutical; Docetaxel; Drug Interactions; Endothelium, Vascular; Excipients; Glycerol; Humans; In Vitro Techniques; Male; Neovascularization, Pathologic; Paclitaxel; Pharmaceutical Vehicles; Polysorbates; Protein Binding; Rats; Rats, Sprague-Dawley; Taxoids	2004
Novel oral formulation of paclitaxel inhibits neointimal hyperplasia in a rat carotid artery injury model. Circulation, 2004, Mar-30, Volume: 109, Issue:12 Topics: Administration, Oral; alpha-Tocopherol; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Carotid Artery Injuries; Carotid Stenosis; Catheterization; Cell Division; Ethylene Glycols; Glycerol; Hyperplasia; Infusions, Parenteral; Intestines; Linoleic Acids; Male; Models, Animal; Myocytes, Smooth Muscle; Paclitaxel; Pharmaceutical Vehicles; Polysorbates; Radiography; Rats; Rats, Sprague-Dawley; Recurrence; Surface-Active Agents; Tocopherols; Tunica Intima; Verapamil	2004
A HPLC validated assay of paclitaxel's related impurities in pharmaceutical forms containing Cremophor EL. Journal of pharmaceutical and biomedical analysis, 2004, Feb-18, Volume: 34, Issue:3 Topics: Chromatography, High Pressure Liquid; Drug Contamination; Glycerol; Paclitaxel; Pharmaceutical Preparations	2004
Disposition kinetics of taxanes after intraperitoneal administration in rats and influence of surfactant vehicles. The Journal of pharmacy and pharmacology, 2004, Volume: 56, Issue:5 Topics: Animals; Antineoplastic Agents, Phytogenic; Area Under Curve; Ascites; Docetaxel; Erythrocytes; Excipients; Female; Glycerol; In Vitro Techniques; Injections, Intraperitoneal; Paclitaxel; Permeability; Pharmaceutical Vehicles; Polysorbates; Rats; Surface-Active Agents; Taxoids; Time Factors; Tissue Distribution	2004
Combination of local, nonviral IL12 gene therapy and systemic paclitaxel treatment in a metastatic breast cancer model. Molecular therapy : the journal of the American Society of Gene Therapy, 2004, Volume: 9, Issue:6 Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma; Cell Line, Tumor; Combined Modality Therapy; Female; Genetic Therapy; Glycerol; Interleukin-12; Lipids; Lung Neoplasms; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Paclitaxel; Plasmids; Polyethyleneimine	2004
Paclitaxel nanoparticles for the potential treatment of brain tumors. Journal of controlled release : official journal of the Controlled Release Society, 2004, Sep-30, Volume: 99, Issue:2 Topics: Adjuvants, Pharmaceutic; Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Chemistry, Pharmaceutical; Fatty Alcohols; Glycerol; Humans; Inhibitory Concentration 50; Male; Nanostructures; Paclitaxel; Pharmaceutical Vehicles; Polyethylene Glycols; Polysorbates; Rats; Rats, Inbred F344; Technology, Pharmaceutical; Tritium	2004
Development and characterization of a novel Cremophor EL free liposome-based paclitaxel (LEP-ETU) formulation. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2005, Volume: 59, Issue:1 Topics: Chemistry, Pharmaceutical; Drug Delivery Systems; Drug Stability; Drug Storage; Freeze Drying; Glycerol; Liposomes; Paclitaxel; Pharmaceutical Vehicles; Solvents	2005
Population pharmacokinetics of orally administered paclitaxel formulated in Cremophor EL. British journal of clinical pharmacology, 2005, Volume: 59, Issue:3 Topics: Absorption; Adult; Aged; Antineoplastic Agents, Phytogenic; Biological Availability; Dose-Response Relationship, Drug; Glycerol; Humans; Middle Aged; Paclitaxel; Pharmaceutical Vehicles; Surface-Active Agents	2005
Comparative in vitro properties and clinical pharmacokinetics of Paclitaxel following the administration of taxol(r) and paxene(r). Cancer biology & therapy, 2005, Volume: 4, Issue:5 Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Excipients; Female; Glycerol; Humans; In Vitro Techniques; Male; Mathematics; Micelles; Middle Aged; Paclitaxel; Solvents; Surface Tension; Surface-Active Agents; Water	2005
Paclitaxel-loaded PLGA nanoparticles: potentiation of anticancer activity by surface conjugation with wheat germ agglutinin. Journal of controlled release : official journal of the Controlled Release Society, 2005, Nov-28, Volume: 108, Issue:2-3 Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chemistry, Pharmaceutical; Drug Synergism; Ethanol; Excipients; Flow Cytometry; Glycerol; Humans; Lung Neoplasms; Mice; Mice, SCID; Nanostructures; Neoplasm Transplantation; Paclitaxel; Solvents; Surface Properties; Wheat Germ Agglutinins	2005
In vivo pharmacokinetic and tissue distribution studies in mice of alternative formulations for local and systemic delivery of Paclitaxel: gel, film, prodrug, liposomes and micelles. Current drug delivery, 2005, Volume: 2, Issue:1 Topics: Animals; Antineoplastic Agents, Phytogenic; Area Under Curve; Carbon Radioisotopes; Chitosan; Gels; Glycerol; Half-Life; Injections, Intravenous; Injections, Subcutaneous; Liposomes; Male; Mice; Micelles; Motion Pictures; Paclitaxel; Prodrugs; Tissue Distribution	2005
In vitro and in vivo studies on vitamin E TPGS-emulsified poly(D,L-lactic-co-glycolic acid) nanoparticles for paclitaxel formulation. Biomaterials, 2006, Volume: 27, Issue:10 Topics: Antineoplastic Agents, Phytogenic; Area Under Curve; Drug Carriers; Drug Delivery Systems; Emulsifying Agents; Glycerol; Humans; Lactic Acid; Nanostructures; Paclitaxel; Polyethylene Glycols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Surface-Active Agents; Vitamin E	2006
The removal of Cremophor EL from paclitaxel for quantitative analysis by HPLC-UV. Journal of pharmaceutical and biomedical analysis, 2006, Apr-11, Volume: 41, Issue:1 Topics: Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Glycerol; Magnetic Resonance Spectroscopy; Mercuric Chloride; Paclitaxel; Spectrophotometry, Infrared; Spectroscopy, Fourier Transform Infrared; Surface-Active Agents; Technology, Pharmaceutical; Time Factors; Ultraviolet Rays	2006
Hydrophobically modified glycol chitosan nanoparticles as carriers for paclitaxel. Journal of controlled release : official journal of the Controlled Release Society, 2006, Mar-10, Volume: 111, Issue:1-2 Topics: Animals; Antineoplastic Agents, Phytogenic; Body Weight; Cell Line, Tumor; Cell Survival; Chitosan; Drug Carriers; Glycerol; Humans; Hydrophobic and Hydrophilic Interactions; Injections, Intravenous; Male; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Nanostructures; Paclitaxel; Technology, Pharmaceutical; Time Factors; Treatment Outcome	2006
Albumin-bound Paclitaxel: in metastatic breast cancer. Drugs, 2006, Volume: 66, Issue:7 Topics: Albumins; Antineoplastic Agents; Breast Neoplasms; Clinical Trials as Topic; Female; Glycerol; Humans; Nanostructures; Neoplasm Metastasis; Neutropenia; Paclitaxel; Treatment Outcome	2006
Albumin-bound Paclitaxel in metastatic breast cancer: viewpoints. Drugs, 2006, Volume: 66, Issue:7 Topics: Albumins; Antineoplastic Agents; Breast Neoplasms; Clinical Trials as Topic; Female; Glycerol; Humans; Nanostructures; Neoplasm Metastasis; Neutropenia; Paclitaxel; Treatment Outcome	2006
Determination of paclitaxel in human plasma following the administration of Genaxol or Genetaxyl by liquid chromatography/tandem mass spectrometry. Rapid communications in mass spectrometry : RCM, 2006, Volume: 20, Issue:14 Topics: Administration, Oral; Antineoplastic Agents, Phytogenic; Chromatography, High Pressure Liquid; Female; Glycerol; Humans; Injections, Intravenous; Paclitaxel; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry	2006
Erythropoietin protects sensory axons against paclitaxel-induced distal degeneration. Neurobiology of disease, 2006, Volume: 24, Issue:3 Topics: Animals; Antineoplastic Agents, Phytogenic; Axons; Cells, Cultured; Dose-Response Relationship, Drug; Drug Carriers; Erythropoietin; Female; Ganglia, Spinal; Glycerol; Humans; Injections, Intraperitoneal; Mice; Nerve Degeneration; Neurons, Afferent; Neuroprotective Agents; Paclitaxel; Recombinant Proteins; Tubulin; Tyrosine	2006
Novel biocompatible intraperitoneal drug delivery system increases tolerability and therapeutic efficacy of paclitaxel in a human ovarian cancer xenograft model. Cancer chemotherapy and pharmacology, 2007, Volume: 60, Issue:6 Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Biocompatible Materials; Chitosan; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Carriers; Drug Implants; Eggs; Female; Glycerol; Humans; Injections, Intraperitoneal; Mice; Mice, Nude; Ovarian Neoplasms; Paclitaxel; Phosphatidylcholines; Xenograft Model Antitumor Assays	2007
Ionically fixed polymeric nanoparticles as a novel drug carrier. Pharmaceutical research, 2007, Volume: 24, Issue:8 Topics: Animals; Antineoplastic Agents, Phytogenic; Area Under Curve; Calcium Chloride; Drug Carriers; Drug Stability; Glycerol; Injections, Intravenous; Lactic Acid; Molecular Weight; Nanoparticles; Paclitaxel; Particle Size; Polyesters; Polyethylene Glycols; Polymers; Rats; Rats, Sprague-Dawley; Spectrophotometry; Static Electricity	2007
Encapsulation of paclitaxel in macromolecular nanoshells. Biomacromolecules, 2007, Volume: 8, Issue:6 Topics: Cell Cycle; Cell Line, Tumor; Cytoskeleton; Drug Delivery Systems; Glycerol; Humans; Macromolecular Substances; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Nanoparticles; Neoplasms; Paclitaxel; Polymers; Solvents	2007
HPLC method for the determination of carboplatin and paclitaxel with cremophorEL in an amphiphilic polymer matrix. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007, Aug-15, Volume: 855, Issue:2 Topics: Antineoplastic Agents; Calibration; Carboplatin; Chromatography, High Pressure Liquid; Glycerol; Paclitaxel; Polyethylene Glycols; Polyglactin 910; Solvents; Surface-Active Agents	2007
Enhanced oral bioavailability of paclitaxel by D-alpha-tocopheryl polyethylene glycol 400 succinate in mice. International journal of pharmaceutics, 2008, Jul-09, Volume: 359, Issue:1-2 Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Biological Availability; Caco-2 Cells; Ethanol; Glycerol; Humans; Injections, Intravenous; Male; Mice; Mice, Inbred BALB C; Microsomes, Liver; Paclitaxel; Permeability; Polyethylene Glycols; Rhodamine 123; Solvents; Steroid Hydroxylases; Vitamin E	2008
Effect of unpurified Cremophor EL on the solution stability of paclitaxel. Pharmaceutical development and technology, 2009, Volume: 14, Issue:1 Topics: Antineoplastic Agents, Phytogenic; Bromphenol Blue; Carboxylic Acids; Colorimetry; Drug Contamination; Drug Stability; Glycerol; Hydrogen-Ion Concentration; Indicators and Reagents; Injections; Molecular Structure; Paclitaxel; Pharmacopoeias as Topic; Solutions; Spectroscopy, Fourier Transform Infrared	2009
Paclitaxel-loaded PEGylated PLGA-based nanoparticles: in vitro and in vivo evaluation. Journal of controlled release : official journal of the Controlled Release Society, 2009, Jan-05, Volume: 133, Issue:1 Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Survival; Drug Carriers; Drug Evaluation, Preclinical; Ethylene Oxide; Excipients; Flow Cytometry; Glycerol; HeLa Cells; Humans; Lactic Acid; Lactones; Male; Mice; Mice, Inbred Strains; Nanoparticles; Neoplasms; Paclitaxel; Particle Size; Polyethylene Glycols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Surface-Active Agents; Survival Analysis	2009
Surfactants influence the distribution of taxanes in peritoneal dissemination tumor-bearing rats. Cancer letters, 2010, Jan-28, Volume: 287, Issue:2 Topics: Animals; Antineoplastic Agents, Phytogenic; Area Under Curve; Ascites; Biological Transport; Carcinoma, Hepatocellular; Cell Line, Tumor; Docetaxel; Female; Glycerol; Injections, Intraperitoneal; Liver Neoplasms; Paclitaxel; Peritoneal Neoplasms; Polysorbates; Rats; Surface-Active Agents; Taxoids; Tissue Distribution	2010
Delayed seizure associated with paclitaxel-Cremophor el in a patient with early-stage breast cancer. Pharmacotherapy, 2009, Volume: 29, Issue:8 Topics: Adult; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Female; Glycerol; Humans; Paclitaxel; Pharmaceutical Vehicles; Seizures; Time Factors	2009
Folate-mediated solid-liquid lipid nanoparticles for paclitaxel-coated poly(ethylene glycol). Drug development and industrial pharmacy, 2010, Volume: 36, Issue:4 Topics: Animals; Antineoplastic Agents, Phytogenic; Folic Acid; Glycerol; Male; Mice; Nanoparticles; Paclitaxel; Polyethylene Glycols; Polymers; Rats; Rats, Sprague-Dawley; Sarcoma 180; Serum Albumin; Solubility	2010
Differential pharmacodynamic effects of paclitaxel formulations in an intracranial rat brain tumor model. The Journal of pharmacology and experimental therapeutics, 2010, Volume: 332, Issue:2 Topics: Animals; Antineoplastic Agents, Phytogenic; Body Weight; Brain Neoplasms; Chemistry, Pharmaceutical; Disease Models, Animal; Drug Screening Assays, Antitumor; Glycerol; Liposomes; Male; Maximum Tolerated Dose; Models, Theoretical; Neutropenia; Paclitaxel; Pharmaceutical Vehicles; Rats; Rats, Inbred Strains; Tumor Burden	2010
Synthesis and characterization of low-toxic amphiphilic chitosan derivatives and their application as micelle carrier for antitumor drug. International journal of pharmaceutics, 2010, Jul-15, Volume: 394, Issue:1-2 Topics: Animals; Antineoplastic Agents, Phytogenic; Chitosan; Dialysis; Dose-Response Relationship, Drug; Drug Carriers; Drug Delivery Systems; Drug Stability; Female; Glycerol; Guinea Pigs; Magnetic Resonance Spectroscopy; Male; Maximum Tolerated Dose; Mice; Micelles; Paclitaxel; Solubility; Spectroscopy, Fourier Transform Infrared; Toxicity Tests, Acute	2010
Targeted cancer therapy with novel high drug-loading nanocrystals. Journal of pharmaceutical sciences, 2010, Volume: 99, Issue:8 Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Carrier Proteins; Chemistry, Pharmaceutical; Drug Delivery Systems; Excipients; Female; Folate Receptors, GPI-Anchored; Glycerol; Hemolysis; Humans; Lung Neoplasms; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy, Electron, Transmission; Nanoparticles; Neoplasm Transplantation; Neoplasms; Paclitaxel; Poloxamer; Receptors, Cell Surface; Surface-Active Agents	2010
Influence of Cremophor EL and genetic polymorphisms on the pharmacokinetics of paclitaxel and its metabolites using a mechanism-based model. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2 Topics: Analysis of Variance; Antineoplastic Agents, Phytogenic; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biotransformation; Chemistry, Pharmaceutical; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP3A; Drug Carriers; Female; Genital Neoplasms, Female; Glycerol; Humans; Middle Aged; Models, Biological; Paclitaxel; Polymorphism, Single Nucleotide	2011
The uptake of paclitaxel and docetaxel into ex vivo porcine bladder tissue from polymeric micelle formulations. Cancer chemotherapy and pharmacology, 2011, Volume: 68, Issue:2 Topics: Administration, Intravesical; Animals; Antineoplastic Agents; Biological Transport; Docetaxel; Drug Carriers; Drug Compounding; Glycerol; In Vitro Techniques; Male; Micelles; Nanoparticles; Paclitaxel; Pharmaceutical Vehicles; Polyesters; Polyethylene Glycols; Polysorbates; Swine; Taxoids; Tissue Distribution; Urinary Bladder; Urinary Bladder Neoplasms	2011
A novel paclitaxel microemulsion containing a reduced amount of Cremophor EL: pharmacokinetics, biodistribution, and in vivo antitumor efficacy and safety. Journal of biomedicine & biotechnology, 2011, Volume: 2011 Topics: Animals; Antineoplastic Agents; Dogs; Emulsions; Female; Glycerol; Humans; Male; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Paclitaxel; Particle Size; Pharmaceutical Vehicles; Rabbits; Rats; Rats, Sprague-Dawley; Tissue Distribution; Xenograft Model Antitumor Assays	2011
Preparation and evaluation of Cremophor-free paclitaxel solid dispersion by a supercritical antisolvent process. The Journal of pharmacy and pharmacology, 2011, Volume: 63, Issue:4 Topics: Animals; Chemistry, Pharmaceutical; Drug Stability; Glycerol; Injections, Intravenous; Male; Nanotechnology; Paclitaxel; Rats; Rats, Sprague-Dawley; Solubility; Tissue Distribution	2011
Localized delivery of paclitaxel using elastic liposomes: formulation development and evaluation. Drug delivery, 2011, Volume: 18, Issue:5 Topics: Animals; Antineoplastic Agents, Phytogenic; Delayed-Action Preparations; Elasticity; Glycerol; Hemolysis; Liposomes; Male; Paclitaxel; Rabbits; Rats; Skin Absorption; Spectroscopy, Fourier Transform Infrared; Toxicity Tests	2011
Dual targeting folate-conjugated hyaluronic acid polymeric micelles for paclitaxel delivery. International journal of pharmaceutics, 2011, Dec-12, Volume: 421, Issue:1 Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Survival; Drug Carriers; Endocytosis; Folate Receptors, GPI-Anchored; Folic Acid; Glycerol; Humans; Hyaluronan Receptors; Hyaluronic Acid; MCF-7 Cells; Micelles; Nanostructures; Paclitaxel; Polymers	2011
Complement activation by polyethoxylated pharmaceutical surfactants: Cremophor-EL, Tween-80 and Tween-20. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2012, Mar-12, Volume: 45, Issue:4 Topics: Antineoplastic Agents; Complement Activation; Docetaxel; Glycerol; Humans; Paclitaxel; Polysorbates; Surface-Active Agents; Taxoids	2012
Nanohybrid systems of non-ionic surfactant inserting liposomes loading paclitaxel for reversal of multidrug resistance. International journal of pharmaceutics, 2012, Jan-17, Volume: 422, Issue:1-2 Topics: Adenosine Triphosphate; Antineoplastic Agents, Phytogenic; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Cycle; Cell Line, Tumor; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Drug Compounding; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Glycerol; Humans; Lipids; Liposomes; Lung Neoplasms; Nanotechnology; Paclitaxel; Particle Size; Poloxamer; Polyethylene Glycols; Rhodamine 123; Solubility; Stearic Acids; Surface-Active Agents; Technology, Pharmaceutical; Time Factors	2012
Evaluation of biosafety and intracellular uptake of Cremophor EL free paclitaxel elastic liposomal formulation. Drug delivery, 2012, Volume: 19, Issue:1 Topics: Animals; Cell Line, Tumor; Chemistry, Pharmaceutical; Drug Evaluation, Preclinical; Elasticity; Female; Glycerol; Humans; Intracellular Fluid; Liposomes; Male; Mice; Paclitaxel; Pharmaceutical Vehicles; Random Allocation; Toxicity Tests, Acute	2012
Paclitaxel in tyrosine-derived nanospheres as a potential anti-cancer agent: in vivo evaluation of toxicity and efficacy in comparison with paclitaxel in Cremophor. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2012, Feb-14, Volume: 45, Issue:3 Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Drug Carriers; Female; Glycerol; Humans; Maximum Tolerated Dose; Mice; Mice, Nude; Nanospheres; Neoplasms; Paclitaxel; Pharmaceutical Vehicles; Tyrosine; Xenograft Model Antitumor Assays	2012
Efficacy and toxicological studies of cremophor EL free alternative paclitaxel formulation. Current drug safety, 2011, Nov-01, Volume: 6, Issue:5 Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Small Cell; Cell Line, Tumor; Deoxycholic Acid; Dose-Response Relationship, Drug; Excipients; Female; Glycerol; Glycine max; Humans; Lethal Dose 50; Liposomes; Lung Neoplasms; Male; Maximum Tolerated Dose; Mice; Paclitaxel; Phosphatidylcholines	2011
Antitumor effect and pharmacokinetics of intraperitoneal NK105, a nanomicellar paclitaxel formulation for peritoneal dissemination. Cancer science, 2012, Volume: 103, Issue:7 Topics: Animals; Antineoplastic Agents, Phytogenic; Area Under Curve; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Ethanol; Female; Glycerol; Humans; Injections, Intraperitoneal; Mice; Mice, Inbred BALB C; Mice, Nude; Micelles; Nanoparticles; Paclitaxel; Rabbits; Stomach Neoplasms; Tissue Distribution; Xenograft Model Antitumor Assays	2012
Pharmacokinetics, tissue distribution and anti-tumour efficacy of paclitaxel delivered by polyvinylpyrrolidone solid dispersion. The Journal of pharmacy and pharmacology, 2012, Volume: 64, Issue:6 Topics: Animals; Antineoplastic Agents, Phytogenic; Area Under Curve; Cell Line, Tumor; Drug Carriers; Female; Glycerol; Humans; Lethal Dose 50; Male; Mice; Mice, Inbred ICR; Mice, Nude; Neoplasms; Paclitaxel; Phytotherapy; Plant Preparations; Povidone; Rats; Rats, Sprague-Dawley; Taxus; Tissue Distribution	2012
Taxol(®)-induced phosphatidylserine exposure and microvesicle formation in red blood cells is mediated by its vehicle Cremophor(®) EL. Nanomedicine (London, England), 2013, Volume: 8, Issue:7 Topics: Cells, Cultured; Chemistry, Pharmaceutical; Erythrocytes; Flow Cytometry; Glycerol; Hemolysis; Human Umbilical Vein Endothelial Cells; Humans; Paclitaxel; Phosphatidylserines	2013
Anti-cancer, pharmacokinetic and biodistribution studies of cremophor el free alternative paclitaxel formulation. Current drug safety, 2014, Volume: 9, Issue:2 Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Ehrlich Tumor; Chemistry, Pharmaceutical; Female; Glycerol; Male; Mice; Paclitaxel; Tissue Distribution	2014
Systemic toxicity induced by paclitaxel in vivo is associated with the solvent cremophor EL through oxidative stress-driven mechanisms. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2014, Volume: 68 Topics: Animals; Antineoplastic Agents, Phytogenic; Catalase; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Erythrocyte Count; Erythrocytes; Glutathione; Glycerol; Hemoglobins; Lipid Peroxidation; Male; Malondialdehyde; Nitric Oxide; Oxidative Stress; Paclitaxel; Rats; Rats, Wistar; Superoxide Dismutase	2014
Pharmacologic sensitivity of paclitaxel to its delivery vehicles drives distinct clinical outcomes of paclitaxel formulations. Molecular pharmaceutics, 2015, Apr-06, Volume: 12, Issue:4 Topics: Albumin-Bound Paclitaxel; Albumins; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Area Under Curve; Chemistry, Pharmaceutical; Clinical Trials as Topic; Drug Carriers; Drug Delivery Systems; Excipients; Glycerol; Humans; Paclitaxel; Pharmaceutical Vehicles; Solvents; Tissue Distribution	2015
Paclitaxel-loaded expansile nanoparticles enhance chemotherapeutic drug delivery in mesothelioma 3-dimensional multicellular spheroids. The Journal of thoracic and cardiovascular surgery, 2015, Volume: 149, Issue:5 Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carboxylic Acids; Cell Line, Tumor; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Ethanol; Excipients; Fluorescent Dyes; Glycerol; Humans; Kinetics; Lung Neoplasms; Mesothelioma; Mesothelioma, Malignant; Microscopy, Confocal; Nanomedicine; Nanoparticles; Paclitaxel; Pinocytosis; Rhodamines; Spheroids, Cellular; Technology, Pharmaceutical	2015
Induction of oxidative stress by Taxol® vehicle Cremophor-EL triggers production of interleukin-8 by peripheral blood mononuclear cells through the mechanism not requiring de novo synthesis of mRNA. Nanomedicine : nanotechnology, biology, and medicine, 2015, Volume: 11, Issue:8 Topics: Albumin-Bound Paclitaxel; Animals; Antineoplastic Agents; Cell Line; Glycerol; Humans; Interleukin-8; Leukocytes, Mononuclear; Mice; Oxidative Stress; Paclitaxel; Pharmaceutical Vehicles; Polyethylene Glycols	2015
Novel Water-Borne Polyurethane Nanomicelles for Cancer Chemotherapy: Higher Efficiency of Folate Receptors Than TRAIL Receptors in a Cancerous Balb/C Mouse Model. Pharmaceutical research, 2016, Volume: 33, Issue:6 Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Drug Carriers; Drug Compounding; Female; Folic Acid; Folic Acid Transporters; Glycerol; Ligands; Mice, Inbred BALB C; Micelles; Nanomedicine; Nanoparticles; Paclitaxel; Polyurethanes; Receptors, TNF-Related Apoptosis-Inducing Ligand; Solubility; Technology, Pharmaceutical; Time Factors; TNF-Related Apoptosis-Inducing Ligand; Tumor Burden	2016
Novel oral administrated paclitaxel micelles with enhanced bioavailability and antitumor efficacy for resistant breast cancer. Colloids and surfaces. B, Biointerfaces, 2017, Feb-01, Volume: 150 Topics: Administration, Oral; Animals; Antineoplastic Agents; Benzylisoquinolines; Breast Neoplasms; Caco-2 Cells; Cell Cycle; Drug Resistance, Neoplasm; Female; Glycerol; Humans; Male; MCF-7 Cells; Mice; Mice, Nude; Micelles; Neoplasm Transplantation; Paclitaxel; Particle Size; Rats; Rats, Sprague-Dawley; Solubility	2017
Studies of the precipitation pattern of paclitaxel in intravenous infusions and rat plasma using laser nephelometry. Pharmaceutical development and technology, 2018, Volume: 23, Issue:1 Topics: Albumins; Animals; Antineoplastic Agents, Phytogenic; Chemistry, Pharmaceutical; Drug Carriers; Glycerol; Infusions, Intravenous; Lasers; Neoplasms; Nephelometry and Turbidimetry; Paclitaxel; Plasma; Rats; Rats, Wistar	2018
Ionic-Liquid-Based Paclitaxel Preparation: A New Potential Formulation for Cancer Treatment. Molecular pharmaceutics, 2018, 06-04, Volume: 15, Issue:6 Topics: Antineoplastic Agents, Phytogenic; Drug Compounding; Drug Delivery Systems; Drug Hypersensitivity; Excipients; Glycerol; HeLa Cells; Humans; Ionic Liquids; Neoplasms; Paclitaxel; Solubility	2018
Polymeric Micelles Based on Modified Glycol Chitosan for Paclitaxel Delivery: Preparation, Characterization and Evaluation. International journal of molecular sciences, 2018, 05-23, Volume: 19, Issue:6 Topics: alpha-Tocopherol; Animals; Antineoplastic Agents; Chitosan; Drug Delivery Systems; Female; Glycerol; Humans; Injections, Intravenous; Male; MCF-7 Cells; Mice; Micelles; Paclitaxel; Particle Size; Polymers; Proton Magnetic Resonance Spectroscopy; Rabbits; Spectroscopy, Fourier Transform Infrared; Static Electricity; X-Ray Diffraction	2018
Liposomal paclitaxel induces fewer hematopoietic and cardiovascular complications than bioequivalent doses of Taxol. International journal of oncology, 2018, Volume: 53, Issue:3 Topics: Animals; Antineoplastic Agents, Phytogenic; Cardiovascular Diseases; Cell Line, Tumor; Cell Survival; Drug Carriers; Drug Compounding; Drug Liberation; Drug Screening Assays, Antitumor; Female; Glycerol; Hematologic Diseases; Humans; Liposomes; Male; Mice; Mice, Inbred ICR; Mice, SCID; Neutropenia; Paclitaxel; Therapeutic Equivalency; Tissue Distribution	2018
Formulation, optimization, hemocompatibility and pharmacokinetic evaluation of PLGA nanoparticles containing paclitaxel. Drug development and industrial pharmacy, 2019, Volume: 45, Issue:3 Topics: Animals; Chemistry, Pharmaceutical; Drug Carriers; Drug Delivery Systems; Female; Glycerol; Humans; Nanoparticles; Paclitaxel; Particle Size; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rats; Rats, Wistar; Solvents; Surface-Active Agents; Technology, Pharmaceutical	2019
In vivo biocompatibility, pharmacokinetics, antitumor efficacy, and hypersensitivity evaluation of ionic liquid-mediated paclitaxel formulations. International journal of pharmaceutics, 2019, Jun-30, Volume: 565 Topics: Administration, Intravenous; Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Drug Delivery Systems; Drug Hypersensitivity; Female; Glycerol; Ionic Liquids; Melanoma; Mice, Inbred C57BL; Paclitaxel; Skin Neoplasms	2019
In Vitro Effects of Paclitaxel and Cremophor EL on Human Riboflavin Transporter SLC52A2. Biological & pharmaceutical bulletin, 2020, Volume: 43, Issue:1 Topics: Antineoplastic Agents, Phytogenic; Glycerol; HEK293 Cells; Humans; Paclitaxel; Receptors, G-Protein-Coupled; Riboflavin	2020
Mast cells activation and high blood tryptase levels due to paclitaxel administration. Is Cremophor EL the culprit?: A case report. Medicine, 2020, Oct-23, Volume: 99, Issue:43 Topics: Aged; Drug Hypersensitivity; Glycerol; Humans; Male; Mast Cells; Paclitaxel; Tryptases; Urologic Neoplasms	2020
Evaluation of the efficacy and safety of a new formulation-lipid emulsion-based PTX injection: Pharmacokinetics, tissue distributions and anticancer effect on human gastric cancer cells in vitro. Biomedical chromatography : BMC, 2021, Volume: 35, Issue:8 Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Chromatography, High Pressure Liquid; Emulsions; Female; Glycerol; Humans; Lipids; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Paclitaxel; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry; Tissue Distribution; Xenograft Model Antitumor Assays	2021