cremophor el has been researched along with glycerol in 380 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 38 (10.00) | 18.7374 |
| 1990's | 101 (26.58) | 18.2507 |
| 2000's | 120 (31.58) | 29.6817 |
| 2010's | 114 (30.00) | 24.3611 |
| 2020's | 7 (1.84) | 2.80 |
| Authors | Studies |
|---|---|
| Cappa, AP; Lovera, C; Margaria, E; Palieri Furlan, L; Prot, N | 1 |
| Ilhan, M; Tuncer, M; Yaris, E | 1 |
| Garbo, GM; Jori, G; Morgan, AR; Polo, L; Reddi, E | 1 |
| Kessel, D | 1 |
| Chester, A; Mankad, P; O'Neil, G; Slavik, Z; Spatenka, J; Yacoub, M | 1 |
| Brat, DJ; Brimijoin, S; Windebank, AJ | 1 |
| Chojnowski, G; Kriegler, AB; Linsenmeyer, ME; Nink, V; Sawyer, WH; Webster, LK; Woodcock, DM | 1 |
| Broxterman, HJ; Dekker, H; Lankelma, J; Schuurhuis, GJ; Spoelstra, EC | 1 |
| Ishide, N; Ishihara, H; Masuda, T; Miura, M; Sasaki, H; Sasaki, T; Sato, M; Shimura, S; Takishima, T | 1 |
| Austrup, F; Kölsch, E; Kucharzik, T | 1 |
| Yee, GC | 1 |
| Abraham, JS; Bentley, FR; Cryer, HM; Garrison, RN | 1 |
| Demant, EJ; Friche, E; Jensen, PB; Nissen, NN; Sehested, M | 1 |
| Anwar, W; Au, WW; Cantelli-Forti, G; Paolini, M; Ramanujam, S | 1 |
| Ames, S; Bowers, VD; Corry, RJ; Jennings, W; Locker, S | 1 |
| Cheng, LS; Kongshaug, M; Moan, J; Rimington, C | 1 |
| Broxterman, HJ; Lankelma, J; Pinedo, HM; Schuurhuis, GJ; Spoelstra, EC; van Heijningen, TH; van Kalken, CK; Vermorken, JB | 1 |
| Capodagli, LC; Coulson, R; Dixon, M; Holohan, PD; Jones, DB; Ross, CR; Sokol, PP | 1 |
| Ennis, M; Lorenz, W | 1 |
| Ennis, M; Kapp, B; Lorenz, W; Lüben, L; Schmal, A | 1 |
| Ennis, M; Gerland, W; Lorenz, W | 1 |
| Ennis, M; Gerland, W; Heise, J; Lorenz, W | 1 |
| Altomonte, M; Andreucci, VE; Conte, G; Dal Canton, A; De Nicola, L; Esposito, C; Sabbatini, M; Uccello, F | 1 |
| Ellenberger, B; Fusco, AC; Li, LH; Mueller, J; Salafsky, B | 1 |
| Busch, M; Cockburn, I; Krupp, P; Schreiber, B | 1 |
| Clark, RL; Finn, WF; Hak, LJ; McCormack, AJ; Sullivan, BA | 1 |
| Esteller, A; Jimenez, R; Monte, MJ; Roman, ID | 1 |
| Chuang, LF; Chuang, RY; Israel, M; Zhao, FK | 1 |
| Dubielzig, RR; Keith, IM; Kiorpes, AL | 1 |
| Garvin, PJ; Niehoff, M; Staggenborg, J | 1 |
| Carrara, M; Cima, L; D'Ancona, S | 1 |
| Besarab, A; Carabasi, RA; Cressman, MD; Green, P; Hirsch, S; Jarrell, BE | 2 |
| Agnes, S; Castagneto, M; Citterio, F; Magalini, SC; Nanni, G | 1 |
| Bahnson, A; Blaha, R; Brady, JE; Burckart, GJ; Giam, CS; Logue, LW; Ptachcinski, RJ; Venkataramanan, R | 1 |
| Boitier, JF; Gaudy, JH; Lhoste, F; Sicard, JF | 1 |
| de Grood, PM; Ruys, AH | 1 |
| Burckart, GJ; Griffith, BP; Hardesty, RJ; Howrie, DL; Ptachcinski, RJ; Rosenthal, JT; Venkataramanan, R | 1 |
| Bonardi, G; Casadio, S; Coppi, G | 1 |
| Bamber, PA; Lawler, PG; McHutchon, A | 1 |
| Doenicke, A; Kapp, B; Lang, S; Lorenz, W; Lüben, L; Ohmann, C; Schmal, A; Schult, H; Weber, D | 1 |
| Pearce, FL | 1 |
| Glen, JB; Hunter, SC | 1 |
| Clarke, RS | 2 |
| Chester, A; Gibbs, NM; Oh, TE | 1 |
| Breeze, RG; Laegreid, WW; Olcott, BM | 1 |
| Descotes, J; Evreux, JC; Laschi-Locquerie, A; Tachon, P | 1 |
| Laxenaire, MC; Moneret-Vautrin, DA; Viry-Babel, F | 1 |
| Descotes, J; Evreux, JC; Guillot, JP; Laschi-Loquerie, A; Tachon, P | 1 |
| Strachan, EB | 1 |
| Davidson, RJ; Orr, JE; Robertson, GS; Russell, IF | 1 |
| Bayer, U; Cheng, SJ; Chouroulinkov, I; Stahl, KW | 1 |
| Dye, D; Watkins, J | 1 |
| Hüttel, MS; Schou Olesen, A | 1 |
| Heavey, C; Meenan, B; Paietta, E; Solomon, MB | 1 |
| Allémann, E; Benrezzak, O; Boyle, RW; Brasseur, N; Gurny, R; Kudrevich, SV; Leroux, JC; Rousseau, J; Van Lier, JE | 1 |
| Güney, Z; Hodoğlugil, U; Zengil, H | 1 |
| Beliveau, R; Jetté, L; Leclerc, JM; Murphy, GF | 1 |
| de Clety, SC; Firdaous, I; Hassoun, A; Otte, JB; Reding, R; Wallemacq, PE | 1 |
| Chan, HS; Doyle, J; Greenberg, ML; Koren, G; Liau-Chu, M; Theis, JG | 1 |
| Balasubramanian, M; Buckingham, LE; Clodfelter, KE; Coon, JS; Emanuele, RM | 1 |
| Cheng, LS; Kongshaug, M; Moan, J; Morgan, AR | 2 |
| Kessel, D; Sykes, E; Woodburn, K | 1 |
| Osann, K; Slater, L; Stupecky, M; Sweet, P; Wetzel, M | 1 |
| Tuncer, M; Yaris, E | 1 |
| Collins, JM; Jamis-Dow, CA; Katki, AG; Klecker, RW | 1 |
| Baker, RM; Brecher, ML; Chervinsky, DS; Hoelcle, MJ; Tebbi, CK | 1 |
| Barber, L; Bertoncello, I; Kriegler, AB; Nilsson, SK; Williams, B; Woodcock, DM | 1 |
| Bergh, J; Brodin, O; Csoka, K; Fridborg, H; Glimelius, B; Hagberg, H; Jonsson, B; Kreuger, A; Nygren, P; Tholander, B | 1 |
| Cheng, G; Jori, G; Kenney, ME; Polo, L; Reddi, E; Rodgers, MA; Soncin, M | 1 |
| Cook, JA; Liebmann, J; Mitchell, JB | 1 |
| Cook, JA; Fisher, J; Liebmann, JE; Lipschultz, C; Mitchell, JB; Teague, D | 1 |
| Cook, JA; Fisher, J; Liebmann, J; Lipschultz, C; Mitchell, JB; Teague, D | 1 |
| Fujimoto, S | 1 |
| Dorr, RT | 1 |
| Bergh, J; Fjällskog, ML; Frii, L | 2 |
| Decker, D; Kessel, D; Sykes, E; Woodburn, K | 2 |
| Adler, LM; Herzog, TJ; Mutch, DG; Rader, JS; Williams, S | 1 |
| Sharma, A; Straubinger, RM | 1 |
| Lodge, NJ | 1 |
| Dolan, ME; Flora, KP; Friedman, HS; Grever, MR; Moschel, RC; Pegg, AE; Vishnuvajjala, BR | 1 |
| Kessel, D; Woodburn, K | 1 |
| Board, PG | 1 |
| Bishop, J; Linsenmeyer, M; Millward, M; Morton, C; Webster, L; Woodcock, D | 1 |
| Blexrud, MD; de Groen, PC; Windebank, AJ | 1 |
| Cornblatt, B; Lee, EJ; Levy, C; Ross, DD; Schiffer, CA; Sridhara, R; Tong, Y; Wooten, PJ | 1 |
| Coll-Cantí, J; Gella, FJ; González-Sastre, F; Munujos, P | 1 |
| Alvestrand, A; Larsson, M; Tibell, A | 1 |
| Boer, HH; Heimans, JJ; Kiburg, B; Moorer-van Delft, CM; Müller, LJ; Vermorken, JB | 1 |
| Ahn, CH; Aszalos, A; Hrycyna, CA; Hwang, M; Licht, T; Pine, PS; Yin, JJ | 1 |
| Cosson, EJ; Millward, MJ; Stokes, KH; Webster, LK | 1 |
| Crinis, NA; Ellis, AG; Webster, LK | 1 |
| Beijnen, JH; Nooijen, WJ; Sparreboom, A; van Tellingen, O | 1 |
| HogenEsch, H; Hopstaken, CM; Radl, J; Van Arkel, C | 1 |
| Allémann, E; Brasseur, N; Kudrevich, SV; Lewis, K; Rousseau, J; van Lier, JE | 1 |
| Alves Rosa, MF; Di Gianni, P; Isturiz, MA; Minnucci, FS; Vulcano, M | 1 |
| Beijnen, JH; Huizing, MT; Nooijen, WJ; Sparreboom, A; van Tellingen, O | 1 |
| Ge, X; McCarthy, ET; Savin, VJ; Sharma, M; Sharma, R | 1 |
| Itoh, Y; Naito, M; Nakayama, Y; Oh-hara, T; Tsuruo, T; Watanabe, T | 1 |
| Papp, A | 1 |
| Csóka, K; Dhar, S; Fridborg, H; Larsson, R; Nygren, P | 1 |
| Windebank, AJ | 1 |
| Grüter, J; Schubiger, G; Shearer, MJ | 1 |
| Arnold, H; Bjerkvig, R; Dahl, O; Gundersen, G; Heese, O; Terzis, AJ; Thorsen, F; Visted, T | 1 |
| Bonfrer, JM; Hageman, PC; Hilkens, JG; Korse, CM; Linders, TC; Molthoff, CF | 1 |
| Beijnen, JH; Huinink, WW; Nuijen, B; Terwogt, JM | 1 |
| Borchardt, RT; Burton, PS; Ho, NF; Nerurkar, MM; Vidmar, TJ | 1 |
| Dutta, S; Ebling, WF; Matsumoto, Y | 1 |
| Dahlback, M; Eirefelt, S; Karlsson, BW; Lundin, PD; Pierzynowski, SG; Podlesny, J; Siwinska-Golebiowska, H; Taljanski, W; Westrom, BR | 1 |
| Gruender, K; Guého, E; Haze, P; Mayser, P; Papavassilis, C; Pickel, M | 1 |
| Brinkmann, T; Kleesiek, K; Körfer, R; Körner, M; Prohaska, W; Tiemann, C | 1 |
| Koren, G; Liau-Chu, M; Theis, JG | 1 |
| Michaud, LB | 1 |
| Brouwer, E; de Bruijn, P; de Vos, AI; Loos, WJ; Nooter, K; Ruijgrok, EJ; Sparreboom, A; Stoter, G; van der Burg, ME; Verweij, J | 1 |
| de Vos, AI; Loos, WJ; Nooter, K; Sparreboom, A; Stoter, G; van der Burg, ME; Verweij, J | 1 |
| Cordes, N; Fietkau, R; Plasswilm, L; Sauer, R | 1 |
| Alving, CR; Muggia, FM; Szebeni, J | 1 |
| Locke, DC; Shao, LK | 1 |
| Anderson, N; Lokich, J | 1 |
| Beijnen, JH; Huizing, MT; Koopmans, FP; Rosing, H | 1 |
| Brouwer, E; Hauns, B; Loos, WJ; Mross, K; Nooter, K; Sparreboom, A; Stoter, G; Verweij, J | 1 |
| Brouwer, E; de Vos, AI; Gianni, L; Locatelli, A; Loos, WJ; Nooter, K; Sparreboom, A; Stoter, G; van der Burg, ME; Verweij, J; Viganò, L | 1 |
| Bishop, JF; Linahan, BM; Linsenmeyer, ME; Millward, MJ; Olver, IN; Rischin, D; Stokes, KH; Toner, GC; Webster, LK; Woodcock, DM | 1 |
| Canada, AL; Ross, HJ; Slater, LM | 1 |
| Beijnen, JH; Dubbelman, RC; Hillebrand, MJ; Koopman, FJ; Panday, VR; Rosing, H; Schellens, JH; ten Bokkel Huinink, WW; van Tellingen, O | 1 |
| Al-Gharably, NM; Al-Shabanah, OA; Badary, OA; Elmazar, MM | 1 |
| Ellis, AG; Webster, LK | 1 |
| Brouwer, E; de Bruijn, P; Gelderblom, H; Loos, WJ; Nooter, K; Pillay, M; Sparreboom, A; Stoter, G; van Zuylen, L; Verweij, J | 1 |
| Boros, M; Kaszaki, J; Nagy, S; Ordögh, B | 1 |
| Boyanova, L; Neshev, G | 1 |
| Engblom, P; Grènman, R; Grènman, S; Hirvonen, H; Kulmala, J; Pulkkinen, JO; Rantanen, V | 1 |
| Beijnen, JH; Huizing, MT; Nooijen, WJ; Panday, VR; Schellens, JH; van Tellingen, O | 1 |
| Brouwer, E; de Bruijn, P; Gelderblom, H; Nooter, K; Pillay, M; Sparreboom, A; Stoter, G; Verweij, J | 1 |
| Jumaa, M; Müller, BW | 1 |
| Beijnen, JH; Bouma, M; Bult, A; Henrar, RE; Manada, C; Nuijen, B | 1 |
| Brasseur, N; Jones, MC; Leroux, JC; Taillefer, J; van Lier, JE | 1 |
| Böhler, J; Frahm, AW; Keller, E; Kunkel, M; Meyer, T | 1 |
| Abdel-Naim, AB; Badary, OA; Hamada, FM; Khalifa, AE | 1 |
| Escousse, A; Gouyon, JB; Guignard, JP; Justrabo, E; Prévot, A; Semama, DS | 1 |
| Brouwer, E; Gianni, L; Loos, WJ; Mross, K; Sparreboom, A; van Zuylen, L; Verweij, J | 1 |
| Cloarec, A; Cornaire, G; Decourt, S; Houin, G; Legendre, JY; Saivin, S; Woodley, JF | 1 |
| Brouwer, E; Buijs, D; De Bruijn, P; Loos, WJ; Pillay, M; Sparreboom, A; Verweij, J | 1 |
| Bessard, G; Deveaux, G; Devillier, P; Hardy, G; Sessa, C; Stanke-Labesque, F | 1 |
| Beijnen, JH; Boschma, MU; Giaccone, G; Huizing, MT; Meerum Terwogt, J; Nannan Panday, VR; Schellens, JH; ten Bokkel Huinink, WW; van Tellingen, O; Veenhof, CH | 1 |
| Böhler, J; Frahm, AW; Meyer, TH | 1 |
| El-Habit, OH; Ramadan, LA; Sayed-Ahmed, MM; Shouman, SA | 1 |
| Brouwer, E; de Bruijn, P; Karlsson, MO; Nooter, K; Sparreboom, A; Stoter, G; van Zuylen, L; Verweij, J | 1 |
| Alving, CR; Barenholz, Y; Danino, D; Priev, A; Savay, S; Szebeni, J; Talmon, Y | 1 |
| Aszalos, A; Bocsi, J; Ladányi, A; Szende, B | 1 |
| Sparreboom, A; van Zuylen, L; Verweij, J | 1 |
| Gianni, L; Grasselli, G; Locatelli, A; Vigano, L | 1 |
| Khan, MA; Nazzal, S; Reddy, IK; Zaghloul, AA | 1 |
| Meyer, D; van der Bijl, P; van Eyk, AD | 1 |
| Frahm, AW; Kunkel, M; Meyer, T; Waidelich, D | 1 |
| Gelderblom, H; Nooter, K; Sparreboom, A; Verweij, J | 1 |
| Beijnen, JH; Bouma, M; Bult, A; Jimeno, JM; Lazaro, LL; Manada, C; Nuijen, B | 1 |
| Gianni, L; Henningsson, A; Karlsson, MO; Sparreboom, A; Verweij, J; Viganò, L | 1 |
| Camlett, I; de Jonge, MJ; Gelderblom, H; Hennis, B; Loos, WJ; Mantel, MA; Sparreboom, A; van der Burg, ME; Verweij, J; Wilms, E | 1 |
| Bardelmeijer, HA; Beijnen, JH; Koopman, FJ; Malingré, MM; Ouwehand, M; Rosing, H; Schellens, JH; Schot, ME; Ten Bokkel Huinink, WW; Van Tellingen, O | 1 |
| Brouwer, E; de Jonge, MJ; Gelderblom, H; Loos, WJ; Nooter, K; Sparreboom, A; Stoter, G; van der Burg, ME; Verweij, J | 1 |
| Behringer, D; Gelderblom, H; Mielke, S; Mross, K; Sparreboom, A; ten Tije, AJ; van Zomeren, DM; Verweij, J | 1 |
| Bardelmeijer, HA; Beijnen, JH; Malingré, MM; Ouwehand, M; Schellens, J; van Tellingen, O | 1 |
| Buijs, D; Gelderblom, H; Nooter, K; Ouwens, L; Sparreboom, A; Stoter, G; van Zomeren, DM; Verweij, J | 1 |
| Frahm, AW; Meyer, T; Waidelich, D | 2 |
| Baldini, E; Bocci, G; Conte, PF; Danesi, R; Del Tacca, M; Di Paolo, A; Fogli, S; Gennari, A; Innocenti, F; Salvadori, B | 1 |
| Briasoulis, E; Haidou, C; Karavasilis, V; Pavlidis, N; Piperidou, C; Tzamakou, E | 1 |
| Burhenne, J; Ding, R; Fricker, R; Haefeli, WE; Martin-Facklam, M; Mikus, G; Walter-Sack, I | 1 |
| Barboza, R; Coradi, ST; Covolan, CC; Maranhão, RC; Rodrigues, DG | 1 |
| Beijnen, JH; Mathôt, RA; Schellens, JH; van den Bongard, HJ; van Tellingen, O | 1 |
| Kao, JP; Polli, JE; Rege, BD | 1 |
| Audus, KL; Borchardt, RT; Burton, PS; Hugger, ED; Novak, BL | 1 |
| Engelbrecht, AH; Meyer, D; Van Der Bijl, P; Van Eyk, AD | 1 |
| Balcerzak, S; Chan, KK; D'Ambrosio, S; Grever, M; Kraut, EH; Liu, J | 1 |
| He, L; Wang, GL; Zhang, Q | 1 |
| Cushman, M; Hejchman, E; Mitra, AK; Pal, D; Patel, J; Udata, C | 1 |
| Berlese, DB; Mello, CF; Rubin, MA; Sauzem, PD; Tabarelli, Z | 1 |
| Beijnen, JH; Boogerd, W; Cleypool, C; Kemper, EM; Mos, HA; van Tellingen, O; van Zandbergen, AE | 1 |
| Milic Askrabic, J; Poprzen, V; Stankovic, M; Vidanovic, D | 1 |
| Ashford, MB; O'Driscoll, CM; Seeballuck, F | 1 |
| Chen, H; Ellis, SJ; Heimlich, K; Kim, SC; Lee, JW; Lemmo, AV; McNulty, C; Oh, HS; Olbert, C; Seo, MH; Yoon, HJ; Zhang, Z | 1 |
| Dyck, J; English, D; Kerjner, A; Lai, JC; Loo, S; McDonald, PC; McManus, BM; Moghadasian, MH; Tranfield, EM; Walker, DC; Wilson, JE; Wong, D | 1 |
| De Giorgi, U; Frassineti, GL; Marangolo, M; Monti, M; Rosti, G | 1 |
| Beijnen, JH; Kemper, EM; Mathôt, RA; Rosing, H; Schellens, JH; van den Bongard, HJ; van Tellingen, O | 1 |
| Bittner, B; Boess, F; Bravo González, RC; Huwyler, J; Walter, I | 1 |
| Lode, HN; Shabat, D; Shamis, M | 1 |
| Figg, WD; Ng, SS; Sparreboom, A | 1 |
| Fujita, T; Furukawa, S; Matsuda, Y; Nishihara, H; Okada, N; Shono, Y; Yamamoto, A | 1 |
| Cho, MC; Kim, DW; Kim, MS; Kim, YG; Kwon, JS; Lee, GS; Youn, TJ | 1 |
| Busso, C; Castro-Prado, MA | 1 |
| Badea, I; Ciutaru, D; Lazara, L; Nicolescu, D; Tudose, A | 1 |
| Furui, N; Furukawa, H; Fushida, S; Ishizaki, J; Jin, M; Miwa, K; Miyamoto, K; Nomura, M; Yamazaki, M; Yokogawa, K; Yoshihara, H | 1 |
| Bikram, M; Furgeson, DY; Janát-Amsbury, MM; Kern, S; Kim, SW; Lee, M; Yockman, JW | 1 |
| Ellis, AG; Loi, S; Michael, M; Millward, MJ; Rischin, D; Stokes, KH; Webster, LK; Yuen, K | 1 |
| Dong, L; Nguyen, J; Wong, P; Yum, A | 1 |
| Allen, DD; Koziara, JM; Lockman, PR; Mumper, RJ | 1 |
| Ishida, S; Iwase, K; Kanada, A; Kobayashi, M; Maemura, Y; Nishimura, Y; Okano, Y; Oyama, Y; Tatsuishi, T; Yamaguchi, JY | 1 |
| Al-Saidan, S; Khan, MA; Samy, AM; Taha, EI | 1 |
| Chang, EJ; Mun, KC | 1 |
| Ahmad, I; Anyarambhatla, G; Ma, L; Sardone, T; Ugwu, S; Xuan, T; Zhang, JA | 1 |
| Beijnen, JH; de Jonge, ME; Huitema, AD; Rodenhuis, S; Schellens, JH | 1 |
| Khan, MA; Nutan, MT; Palamakula, A | 1 |
| Furukawa, H; Ishizaki, J; Jin, M; Miyamoto, K; Mizuhara, Y; Nomura, M; Shimada, T; Yokogawa, K | 1 |
| Aliabadi, HM; Lavasanifar, A; Mahmud, A; Sharifabadi, AD | 1 |
| Figg, WD; Loos, WJ; Scripture, CD; Sparreboom, A; Szebeni, J | 1 |
| Iwase, K; Kanada, A; Kobayashi, M; Mishima, K; Nishimura, Y; Oyama, Y; Tatsuishi, T; Yamaguchi, JY | 1 |
| Baker, MT; Naguib, M | 1 |
| Croy, SR; Kwon, GS | 1 |
| Lim, LY; Mo, Y | 1 |
| Dhanikula, AB; Panchagnula, R; Singh, DR | 1 |
| Feng, SS; Win, KY | 1 |
| DeVido, DR; Perdue, JD; Seaton, PJ; Tyrell, JA | 1 |
| Choi, K; Chung, H; Jeong, SY; Kim, IS; Kim, JH; Kim, K; Kim, S; Kim, YS; Kwon, IC; Park, JH; Park, RW | 1 |
| Li, ZD; Shen, HR; Zhong, MK | 1 |
| Gallego, JG; Gutiérrez, MB; Miguel, BS; Tuñón, MJ; Villares, C | 1 |
| Fang, XL; Sha, XY | 1 |
| Gradishar, WJ | 1 |
| Keating, GM; Robinson, DM | 1 |
| Davidson, N; Harper, P; Harries, M; Ibrahim, N | 1 |
| Chu, ZE; Figg, WD; Gardner, ER; Liau, CT; Sparreboom, A | 1 |
| Charman, SA; Katneni, K; Porter, CJ | 2 |
| Höke, A; Jack, C; Lambrinos, GL; Melli, G; Ringkamp, M | 1 |
| Hung, O | 1 |
| Connor, HD; Forman, DT; Lemasters, JJ; Li, X; Mason, RP; Thurman, RG; Zhong, Z | 1 |
| Charman, WN; Cuiné, JF; Edwards, GA; Porter, CJ; Pouton, CW | 1 |
| Allen, C; De Souza, R; Grant, J; Piquette-Miller, M; Vassileva, V | 1 |
| Chang, DH; Kim, BO; Kim, SO; Lee, SW; Seo, MH; Shim, MS | 1 |
| Gabor, F; Göker, E; Güneri, T; Karabulut, B; Karasulu, HY | 1 |
| Pishko, MV; Zahr, AS | 1 |
| Chitkara, D; Kumar, N; Mittal, A | 1 |
| Chen, HL; Hu, Y; Liang, WQ | 1 |
| Meng, J; Zheng, L | 1 |
| Dixit, RP; Nagarsenker, MS | 1 |
| An, H; Bao, Y; He, Y; Mo, X; Wang, X; Xu, X | 1 |
| Fransson, M; Gréen, H | 1 |
| Dong, Y; Ng, WK; Surana, U; Tan, RB | 1 |
| Chen, JS; Chen, PM; Chu, Z; Figg, WD; Gardner, ER; Liau, CT; Lin, YC; Sparreboom, A; Wang, HM; Yang, MH | 1 |
| Chang, YW; Chao, YS; Chen, CT; Chiang, TH; Ho, PY; Lin, HL; Lo, YK; Wu, HY; Wu, SH; Yao, HT; Yeh, TK | 1 |
| Dong, R; Wang, W; Wu, J; Yu, A; Zhai, G; Zhu, W | 1 |
| Nie, SF; Pan, WS; Sun, JY; Wang, J; Wang, Y; Zhou, XT | 1 |
| Davies, NM; Forrest, ML; Kwon, GS; Xiong, MP; Yáñez, JA | 1 |
| Ayoub, SS; Dehner, F; Greim, C; Laufer, S; Luik, S | 1 |
| Agharkar, SN; Gogate, US; Schwartz, PA | 1 |
| Danhier, F; Feron, O; Jérôme, C; Lecouturier, N; Marchand-Brynaert, J; Préat, V; Vroman, B | 1 |
| Khar, RK; Shafiq, S; Shakeel, F | 1 |
| Bae, A; del Rosario, LS; Demirdirek, B; Uhrich, KE; Wang, J | 1 |
| Diao, YY; Fang, QL; Gao, JQ; Han, M; He, CX; He, QJ; Hu, YZ; Liang, WQ; Xu, DH; Yang, B; Yang, XC | 1 |
| Chan, CK; Chang, Q; Meng, ZY; Sun, JB; Tong, HH; Wang, GN; Wang, YT; Xi, J; Zheng, Y | 1 |
| Huang, JG; Li, G; Si, LQ; Yan, F | 1 |
| Alani, AW; Kwon, GS; Rao, DA; Rockich, NC; Shin, HC | 1 |
| Ito, C; Kamijo, Y; Miyamoto, K; Nomura, M; Sai, Y | 1 |
| Kossoff, E; O'Connor, TL | 1 |
| Choi, MK; Chung, SJ; Cui, FD; Kim, DD; Kim, JS; Mu, CF; Shim, CK; Yin, YM | 1 |
| Tang, C; Wu, L; Yin, C | 1 |
| Harrold, JM; Mager, DE; Mazurchuk, RV; Straubinger, RM; Tamburlin, JH; Zhou, R | 1 |
| Hong, M; Liu, C; Pei, Y; Zhu, S | 1 |
| Binkhathlan, Z; Brocks, DR; Hamdy, DA; Lavasanifar, A | 2 |
| Hou, L; Sun, L; Yao, J; Zhang, ZQ; Zhou, JP | 1 |
| Gong, T; Hao, X; Liu, J; Ruan, J; Yang, F; Zhang, Z; Zhu, D | 1 |
| Huo, M; Li, H; Li, J; Wu, Y; Yu, D; Zhang, Y; Zhou, J; Zou, A | 1 |
| Bathula, SR; Conwell, C; Huang, L; Liu, F; Liu, Y; Park, JY; Zhang, Y | 1 |
| Berman, D; Burris, HA; Jones, S; Murthy, B | 1 |
| Dai, YL; Ran, YP; Zhang, RF | 1 |
| Fransson, MN; Friberg, LE; Gréen, H; Litton, JE | 1 |
| Burt, H; Jackson, J; Tsallas, A | 1 |
| Boekhout, T; Cafarchia, C; da Silva Machado, ML; Ferreiro, L; Figueredo, LA; Guillot, J; Latrofa, MS; Otranto, D | 1 |
| Kamiyama, N; Kashiwayanagi, M; Noguchi, T | 1 |
| Kedjinda, W; Maneenuan, D; Setthacheewakul, S; Wiwattanapatapee, R | 1 |
| Fan, C; Fan, Y; Huang, Y; Li, X; Liu, Y; Wu, F; Yue, Y; Zhou, Y | 1 |
| Chen, S; Nie, SF; Pan, WS; Wang, X; Wang, Y; Wu, KC; Zhang, Q; Zhang, X; Zhao, BX; Zhao, X | 1 |
| Atilla, P; Bolay, H; Cakar, AN; Dalkara, T; Emre-Aydıngöz, S; Erdem, SR; Tuncer, M | 1 |
| Chi, SC; Choi, HG; Hwang, DH; Lyoo, WS; Park, JH; Shanmugam, S; Woo, JS; Yan, YD; Yong, CS | 1 |
| Jain, S; Tiwary, AK; Utreja, P | 2 |
| Chan, WC; du Plessis, LH; Grobler, AF; Haynes, RK; Kotzé, AF; Smith, PJ; Steyn, JD; Wiesner, L | 1 |
| Ghorab, MK; Hashem, FM; Ismail, A; Nasr, M; Shaker, DS | 1 |
| Manickam, S; Nashiru, B; Tang, SY; Wei, TK | 1 |
| Dalrymple, DM; Prajapati, HN; Serajuddin, AT | 1 |
| Hu, L; Jia, Y; Niu, F; Wu, H; Yan, C; Yang, X | 1 |
| Cao, W; He, Z; Li, X; Lian, H; Liu, Y; Sun, J; Sun, Y; Wang, S; Wang, Y; Yang, J | 1 |
| Michniak-Kohn, B; Zhang, J | 1 |
| Kataoka, M; Masaoka, Y; Sakuma, S; Yamashita, S; Yokoyama, T | 1 |
| Czúcz, J; Révész, C; Rosivall, L; Rozsnyay, Z; Szebeni, J; Weiszhár, Z | 1 |
| Chen, L; Deng, Y; Gao, Y; Ji, X; Li, Y; Zhang, Z | 1 |
| Bandyopadhyay, S; Kapil, R; Katare, OO; Khurana, L; Singh, B | 1 |
| Bushman, J; Garbuzenko, OB; Gounder, MK; Kohn, J; Minko, T; Sheihet, L | 1 |
| Chen, Z; Lu, Y; Qi, J; Wu, W | 1 |
| Alayoubi, A; Nazzal, S; Satyanarayanajois, SD; Sylvester, PW | 1 |
| Chen, L; Liu, F; Tan, F; Wang, J | 1 |
| Jain, S; Khandhuja, KL; Tiwary, AK; Utreja, P; Yadav, S | 1 |
| Emoto, S; Ishigami, H; Kishikawa, J; Kitayama, J; Yamaguchi, H; Yamashita, H | 1 |
| Alanazi, FK; Mohsin, K; Shahba, AA | 1 |
| Chen, X; Liu, X; Scott, H; Sun, J; Wang, S; Zhang, Q; Zhang, X | 1 |
| Bandivadekar, M; Choudhari, A; Kaul-Ghanekar, R; Koppikar, S; Pancholi, S | 1 |
| He, Z; Li, S; Liu, H; Wang, Y; Xu, H | 1 |
| Engel, A; Keiser, M; Oswald, S; Siegmund, W | 1 |
| García-Díaz, M; Hamblin, MR; Kawakubo, M; Mora, M; Mroz, P; Nonell, S; Sagristà, ML | 1 |
| Ge, M; Quan, D; Wang, T; Yang, X | 1 |
| Abdallah, OY; Elnaggar, YS; Elsheikh, MA; Gohar, EY | 1 |
| Dufour, S; Geny, B; Kindo, M; Lampert, E; Mettauer, B; N' Guessan, BB; Ribera, F; Sanchez, H; Ventura-Clapier, R; Zoll, J | 1 |
| Balasubramanian, T; Bocian, DF; Diers, JR; Hamblin, MR; Holten, D; Huang, YY; Lindsey, JS; Luo, D; Yang, E | 1 |
| Ehinger, KH; Elmér, E; Hansson, MJ; Sjövall, F | 1 |
| Dai, Y; Jia, L; Shao, J; Xie, J; Xue, J; Ye, J; Zhao, W | 1 |
| Abdul-Gani, SS; Abdul-Malek, E; Basri, HB; Basri, M; Karjiban, RA; Shamsuddin, AF; Zainol, S | 1 |
| Bocsik, A; Deli, MA; Kiss, L; Ozsvári, B; Puskás, LG; Szabó-Révész, P; Veszelka, S; Walter, FR | 1 |
| Andringa, G; Egberts, AC; Fens, MH; Gaillard, CA; Rasmussen, JT; Sachini, N; Schiffelers, RM; Vader, P; van Oirschot, BA; van Solinge, WW; van Wijk, R | 1 |
| Brossard, D; Crauste-Manciet, S; Dutot, M; Guigner, JM; Mignet, N; Muhamed, S; Rat, P; Scherman, D; Sigward, E | 1 |
| Andrade, MF; Azzolini, AE; Kabeya, LM; Lucisano-Valim, YM; Piatesi, F; Polizello, AC | 1 |
| Ancha, M; Angalakurthi, S; Jane, M; Kovacs, K; Lee, S; Negrito, M; Nwaneri, A; Petrikovics, I; Rasheed, S | 1 |
| Chaw, CS; Elkordy, AA; Haj-Ahmad, RR; Moore, A | 1 |
| Ashton, JC; Rivers-Auty, J | 1 |
| Dou, J; Huang, X; Su, L; Yang, R; Zhai, G | 1 |
| Dai, WG; Dong, LC; Song, Y | 1 |
| Kanaujia, P; Ng, WK; Tan, RB | 1 |
| Baskaran, R; Madheswaran, T; Yong, CS; Yoo, BK | 1 |
| Capgras, S; Legué, E; Nicolas, JF; Sequeira, I | 1 |
| Jain, SK; Kumar, N; Mahajan, M; Roy, P; Tiwary, AK; Utreja, P | 1 |
| Chevalier, C; Nicolas, JF; Petit, AC | 1 |
| Agrawal, AG; Gide, PS; Kumar, A | 1 |
| Malamataris, S; Nikolakakis, I | 1 |
| Campos, FC; Cecchini, AL; Cecchini, R; Martins-Pinge, MC; Panis, C; Victorino, VJ | 1 |
| Bernkop-Schnürch, A; Hauptstein, S; Hintzen, F; Laffleur, F; Müller, C; Perera, G | 1 |
| Alayoubi, A; Alqahtani, S; Kaddoumi, A; Nazzal, S; Sylvester, PW | 1 |
| Cai, J; Hu, H; Huang, M; Li, Y; Song, J; Tian, N; Wang, Y; Wu, C; Xing, Q | 1 |
| Ding, J; Li, J; Li, Y; Mao, S; Zhang, X | 1 |
| Barresi, AA; Fissore, D; Zelenková, T | 1 |
| Boyd, BJ; Goodchild, CS; Kolosov, A; Serrao, JM | 1 |
| Lansky, AJ; Mena, C; Ng, VG; Pietras, C | 1 |
| Chen, N; Li, Y; Palmisano, M; Zhou, S | 1 |
| Catalano, P; Colby, A; Colson, YL; Grinstaff, MW; Hofferberth, SC; Lei, H; Liu, R; Tevis, KM | 1 |
| Banba, H; Kumagai, Y; Kusuhara, H; Maeda, K; Sugiyama, Y; Takayama, K; Takeda-Morishita, M; Tomaru, A | 1 |
| Hollmann, MW; Sear, JW | 1 |
| Hollmann, MW; Kharasch, ED | 1 |
| Abdallah, OY; Allam, AN; Fouda, MA; Komeil, IA | 1 |
| Han, SD; Jang, SW; Jung, SW; Kang, MJ; Kim, BM; Son, M | 1 |
| Clogston, JD; Dobrovolskaia, MA; Ilinskaya, AN; McNeil, SE | 1 |
| Dhande, RD; Khunt, A; Patel, AA; Thakkar, HP | 1 |
| Gordon, WP; Groessl, T; Liu, B; Richmond, W; Tuntland, T | 1 |
| Cho, NJ; Fülöp, T; Jackman, JA; Mészáros, T; Szebeni, J; Urbanics, R | 1 |
| Dong, D; Lu, D; Wang, S; Wu, B; Zhang, T | 1 |
| Ajorlou, E; Khosroushahi, AY; Yeganeh, H | 1 |
| Cho, HJ; Jeong, JY; Ko, HJ; Lee, JJ; Lee, SY; Shim, A | 1 |
| Cho, HR; Choi, YS; Choi, YW; Ho, MJ; Jung, HJ; Kang, MJ; Lee, DR; Oh, CH; Park, JS; Yoon, SH | 1 |
| Bu, P; Cheng, X; Dalrymple, D; Narayanan, S; Serajuddin, AT | 1 |
| Couto, RO; Freitas, O; Kaminski, RC; Nunes, KM; Pulcinelli, SH; Sarmento, VH; Teixeira, CC | 1 |
| Chen, M; Lam, CW; Xiao, L; Yi, T; Zhou, H | 1 |
| Ding, R; Fu, Y; Gong, T; Li, H; Luo, J; Zhang, T; Zhang, Z | 1 |
| Buttchevitz, A; Caon, T; de Oliveira Benedet, P; Kruger, JH; Lemos-Senna, E; Mendes, C; Silva, MAS | 1 |
| Aboud, HM; Ali, AA; Hassan, AH; Johnston, TP; Mahmoud, MO | 1 |
| Al-Najjar, BY; Alhnan, MA; El Nemr, S; Elhissi, AMA; Omer, HK | 1 |
| Galvanin, F; Liu, D; Yu, Y | 1 |
| Abd-Elsalam, WH; Al-Mahallawi, AM; El-Zahaby, SA | 1 |
| Cetina-Čižmek, B; Filipović-Grčić, J; Hafner, A; Juretić, M; Lovrić, J; Pepić, I | 1 |
| Chowdhury, MR; Goto, M; Kamiya, N; Moniruzzaman, M; Moshikur, RM; Tahara, Y; Wakabayashi, R | 2 |
| Cui, F; Gong, X; Li, Q; Liang, N; Sun, S; Yan, P | 1 |
| Chen, YH; Huang, ST; Li, WS; Lin, CT; Wang, YP; Wu, HC | 1 |
| Abdel-Rahman, SI; Alanazi, FK; Shahba, AA | 1 |
| Katsumi, H; Kusamori, K; Morishita, M; Sakane, T; Sawangrat, K; Tanaka, A; Yamamoto, A; Yamashita, S | 1 |
| Ajmal, G; Bonde, GV; Kapoor, R; Mishra, B; Mittal, A; Mittal, P; Vardhan, H | 1 |
| Benameur, H; Chalmers, DK; Clulow, AJ; Nowell, CJ; Pham, AC; Porter, CJH; Pouton, CW; Suys, EJA; Warren, DB | 1 |
| Aserin, A; Ezrahi, S; Garti, N | 1 |
| Jiang, D; Jin, W; Li, H; Meng, Y; Song, H; Tan, X; Wen, J; Zhang, Y; Zheng, W | 1 |
| Guan, Y; Wang, X; Xiao, H; Zhang, Y; Zhao, H | 1 |
| Andersson, CM; Christensen, ST; Edvinsson, L; Grell, AS; Haanes, KA; Johansson, SE | 1 |
| Adane, E; Leggas, M; Liu, X; Tang, F | 1 |
| Arczewska, M; Gagos, M; Janik-Zabrotowicz, E; Skrzypek, TH; Swietlicka, I; Terpilowski, K; Zubik, M | 1 |
| Chen, T; Dalvi, P; Harper, PA; Hino, H; Ito, S; Sun, L; Yang, M | 1 |
| Arcangeli, M; Baldari, B; D'Errico, S; Fineschi, V; Frati, P; Santurro, A | 1 |
| Arczewska, M; Janik-Zabrotowicz, E; Prochniewicz, P; Świetlicka, I; Terpiłowski, K | 1 |
| Fan, G; Fei, Y; Shen, F; Wang, Y; Wu, S | 1 |
| Dano, R; Li, B; Li, Y; Orahoske, CM; Su, B; Zhang, W | 1 |
| McFeely, SJ; Ragueneau-Majlessi, I; Wang, Y; Wu, C; Yu, J | 1 |
| Cheon, S; Choi, HG; Choi, YJ; Im, D; Ji, SH; Jin, SG; Kim, JO; Kim, JS; Lim, SJ; Oh, KT; Ud Din, F; Woo, MR; Youn, YS | 1 |
14 review(s) available for cremophor el and glycerol
| Article | Year |
|---|---|
Dosage forms of cyclosporine.
Topics: Administration, Oral; Capsules; Cyclosporine; Drug Stability; Glycerol; Humans; Injections, Intravenous; Solutions | 1991 |
New drugs--boon or bane? Premedication and intravenous induction agents.
Topics: Alfaxalone Alfadolone Mixture; Anesthesia, Intravenous; Anesthetics; Animals; Benzodiazepines; Diazepam; Etomidate; Glycerol; Humans; Ketamine; Lorazepam; Male; Mice; Phenols; Preanesthetic Medication; Propofol; Thiopental; Thrombophlebitis | 1983 |
Pharmacology and toxicology of Cremophor EL diluent.
Topics: Animals; Drug Hypersensitivity; Glycerol; Humans; Paclitaxel; Pharmaceutical Vehicles; Solvents; Surface-Active Agents | 1994 |
Alternative formulations of paclitaxel.
Topics: Antineoplastic Agents, Phytogenic; Chemistry, Pharmaceutical; Drug Carriers; Emulsions; Glycerol; Humans; Infusions, Intravenous; Liposomes; Paclitaxel; Prodrugs; Solvents | 1997 |
Methods for preventing reactions secondary to Cremophor EL.
Topics: Anaphylaxis; Chemistry, Pharmaceutical; Cyclosporine; Drug Compounding; Glycerol; Humans; Pharmaceutical Vehicles | 1997 |
Role of formulation vehicles in taxane pharmacology.
Topics: Animals; Anthracyclines; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chemistry, Pharmaceutical; Cyclosporine; Drug Hypersensitivity; Drug Resistance, Multiple; Glycerol; Humans; Micelles; Neoplasms; Nervous System Diseases; Paclitaxel; Polysorbates; Surface-Active Agents | 2001 |
Drug interactions of paclitaxel and docetaxel and their relevance for the design of combination therapy.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Chemistry, Pharmaceutical; Cisplatin; Docetaxel; Drug Administration Schedule; Drug Interactions; Glycerol; Humans; Neoplasms; Paclitaxel; Pharmaceutical Vehicles; Radiotherapy, Adjuvant; Taxoids; Vinca Alkaloids | 2001 |
Cremophor EL: the drawbacks and advantages of vehicle selection for drug formulation.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chemistry, Pharmaceutical; Glycerol; Humans; Hyperlipidemias; Lipoproteins; Nervous System Diseases; Surface-Active Agents | 2001 |
Propofol: the challenges of formulation.
Topics: Chemistry, Pharmaceutical; Cyclodextrins; Drug Stability; Edetic Acid; Emulsions; Glycerol; Micelles; Particle Size; Prodrugs; Propofol; Sulfites | 2005 |
Albumin-bound paclitaxel: a next-generation taxane.
Topics: Albumin-Bound Paclitaxel; Albumins; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Chemistry, Pharmaceutical; Drug Administration Schedule; Drug Delivery Systems; Endothelial Cells; Female; Glycerol; Humans; Infusions, Intra-Arterial; Nanotechnology; Neoplasm Metastasis; Osteonectin; Paclitaxel; Randomized Controlled Trials as Topic; Solvents; Survival Rate; Therapeutic Equivalency | 2006 |
[Advances in the study of excipient inhibitors of intestinal P-glycoprotein].
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; beta-Cyclodextrins; Biological Availability; Chitin; Excipients; Glycerol; Humans; Intestinal Absorption; Polyethylene Glycols; Surface-Active Agents | 2008 |
Vehicles for lipophilic drugs: implications for experimental design, neuroprotection, and drug discovery.
Topics: Cyclodextrins; Dimethyl Sulfoxide; Drug Discovery; Ethanol; Glycerol; Neuroprotective Agents; Pharmaceutical Vehicles; Research Design; Solubility | 2013 |
Local delivery of paclitaxel in the treatment of peripheral arterial disease.
Topics: Angioplasty, Balloon; Clinical Trials as Topic; Drug Evaluation, Preclinical; Drug-Eluting Stents; Glycerol; Humans; Infusions, Intravenous; Iohexol; Nanoparticles; Paclitaxel; Peripheral Arterial Disease; Pharmaceutical Vehicles; Tubulin Modulators | 2015 |
Basic principles of drug delivery systems - the case of paclitaxel.
Topics: Antineoplastic Agents, Phytogenic; Biological Availability; Biological Transport; Drug Delivery Systems; Drug Stability; Emulsions; Glycerol; Humans; Microtubules; Mitosis; Nanostructures; Neoplasms; Paclitaxel; Solubility; Solvents; Tumor Cells, Cultured | 2019 |
23 trial(s) available for cremophor el and glycerol
| Article | Year |
|---|---|
Local reactions to i.v. diazepam in three different formulations.
Topics: Adult; Castor Oil; Diazepam; Emulsions; Glycerol; Humans; Infusions, Parenteral; Pain; Propylene Glycols; Thrombophlebitis | 1980 |
Anaphylactoid reactions in children receiving high-dose intravenous cyclosporine for reversal of tumor resistance: the causative role of improper dissolution of Cremophor EL.
Topics: Adolescent; Anaphylaxis; Antineoplastic Combined Chemotherapy Protocols; Azo Compounds; Child; Child, Preschool; Cyclosporine; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Ethanol; Glycerol; Humans; Immunosuppressive Agents; Infusions, Intravenous; Pharmaceutical Vehicles; Premedication; Rhabdomyosarcoma; Solubility; Solvents; Statistics, Nonparametric | 1995 |
Plasma vitamin K1 and PIVKA-II after oral administration of mixed-micellar or cremophor EL-solubilized preparations of vitamin K1 to normal breast-fed newborns.
Topics: Biological Availability; Biomarkers; Glycerol; Humans; Infant, Newborn; Micelles; Protein Precursors; Prothrombin; Solubility; Surface-Active Agents; Vitamin K | 1997 |
Phase I trial of cremophor EL with bolus doxorubicin.
Topics: Adult; Aged; Antibiotics, Antineoplastic; Cross-Over Studies; Doxorubicin; Female; Glycerol; Humans; Male; Middle Aged; Neoplasms; Pharmaceutical Vehicles | 1998 |
Phase I and pharmacologic study of weekly doxorubicin and 1 h infusional paclitaxel in patients with advanced breast cancer.
Topics: Adult; Alopecia; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Dose-Response Relationship, Drug; Doxorubicin; Drug Administration Schedule; Female; Glycerol; Humans; Infusions, Intravenous; Middle Aged; Neutropenia; Paclitaxel | 1998 |
Inter-relationships of paclitaxel disposition, infusion duration and cremophor EL kinetics in cancer patients.
Topics: Antineoplastic Agents, Phytogenic; Glycerol; Humans; Infusions, Intravenous; Neoplasms; Paclitaxel; Surface-Active Agents | 2000 |
Measurement of fraction unbound paclitaxel in human plasma.
Topics: Antineoplastic Agents, Phytogenic; Binding, Competitive; Dose-Response Relationship, Drug; Female; Glycerol; Humans; Male; Metabolic Clearance Rate; Middle Aged; Paclitaxel; Plasma | 2000 |
Cremophor EL pharmacokinetics in a phase I study of paclitaxel (Taxol) and carboplatin in non-small cell lung cancer patients.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Carboplatin; Carcinoma, Non-Small-Cell Lung; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Glycerol; Humans; Lung Neoplasms; Male; Middle Aged; Paclitaxel; Pharmaceutical Vehicles | 2000 |
Pharmacokinetic modeling of paclitaxel encapsulation in Cremophor EL micelles.
Topics: Adult; Antineoplastic Agents, Phytogenic; Area Under Curve; Blood Proteins; Excipients; Female; Glycerol; Half-Life; Humans; Male; Micelles; Middle Aged; Models, Biological; Paclitaxel; Protein Binding | 2001 |
Mechanism-based pharmacokinetic model for paclitaxel.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Doxorubicin; Female; Glycerol; Humans; Infusions, Intravenous; Male; Mathematics; Middle Aged; Neutropenia; Paclitaxel; Solvents | 2001 |
Dose and schedule-finding study of oral topotecan and weekly cisplatin in patients with recurrent ovarian cancer.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Schedule; Female; Glycerol; Humans; Middle Aged; Neoplasm Recurrence, Local; Ovarian Neoplasms; Topotecan | 2001 |
The co-solvent Cremophor EL limits absorption of orally administered paclitaxel in cancer patients.
Topics: Administration, Oral; Antineoplastic Agents, Phytogenic; Area Under Curve; Cyclosporine; Drug Combinations; Feces; Glycerol; Humans; Intestinal Absorption; Neoplasms; Paclitaxel; Pharmaceutical Vehicles; Polysorbates; Solvents | 2001 |
Comparative pharmacokinetics of unbound paclitaxel during 1- and 3-hour infusions.
Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Area Under Curve; Drug Administration Schedule; Female; Glycerol; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasms; Neutropenia; Paclitaxel; Surface-Active Agents; Thrombocytopenia; Time Factors | 2002 |
Influence of Cremophor El on the bioavailability of intraperitoneal paclitaxel.
Topics: Aged; Antineoplastic Agents, Phytogenic; Ascitic Fluid; Biological Availability; Female; Gastrointestinal Diseases; Glycerol; Hematologic Diseases; Humans; Injections, Intraperitoneal; Injections, Intravenous; Mesothelioma; Middle Aged; Ovarian Neoplasms; Paclitaxel | 2002 |
Pharmacokinetics and pharmacodynamics of combination chemotherapy with paclitaxel and epirubicin in breast cancer patients.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Doxorubicin; Drug Administration Schedule; Drug Interactions; Epirubicin; Female; Glycerol; Humans; In Vitro Techniques; Infusions, Intravenous; Middle Aged; Paclitaxel | 2002 |
Dose-dependent increase of saquinavir bioavailability by the pharmaceutic aid cremophor EL.
Topics: Administration, Oral; Adult; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Glycerol; HIV Protease Inhibitors; Humans; Male; Pharmaceutical Vehicles; Saquinavir | 2002 |
A randomized cross-over trial to determine the effect of Cremophor EL on the pharmacodynamics and pharmacokinetics of carboplatin chemotherapy.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Area Under Curve; Carboplatin; Cross-Over Studies; Female; Glycerol; Humans; Male; Metabolic Clearance Rate; Middle Aged; Neoplasms; Surface-Active Agents | 2004 |
Comparison of two types of population pharmacokinetic model structures of paclitaxel.
Topics: Adult; Aged; Algorithms; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Carboplatin; Computer Simulation; Female; Genital Neoplasms, Female; Glycerol; Humans; Middle Aged; Models, Biological; Paclitaxel; Pharmaceutical Vehicles; Reproducibility of Results | 2008 |
Oral bioavailability of a novel paclitaxel formulation (Genetaxyl) administered with cyclosporin A in cancer patients.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents, Phytogenic; Area Under Curve; Biological Availability; Cyclosporine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Glycerol; Humans; Immunosuppressive Agents; Infusions, Intravenous; Male; Middle Aged; Neoplasms; Paclitaxel | 2008 |
Tanespimycin pharmacokinetics: a randomized dose-escalation crossover phase 1 study of two formulations.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Benzoquinones; Cross-Over Studies; Excipients; Female; Glycerol; HSP90 Heat-Shock Proteins; Humans; Lactams, Macrocyclic; Male; Middle Aged; Suspensions | 2011 |
Oxidative capacities of cardiac and skeletal muscles of heart transplant recipients: mitochondrial effects of cyclosporin-A and its vehicle Cremophor-EL.
Topics: Cyclosporine; Dose-Response Relationship, Drug; Electron Transport; Electron Transport Chain Complex Proteins; Female; Glycerol; Heart Transplantation; Humans; Immunosuppressive Agents; Male; Middle Aged; Mitochondria, Heart; Mitochondria, Muscle; Muscle, Skeletal; Myocardium; Oxygen Consumption; Pharmaceutical Vehicles; Transplants | 2014 |
Bioequivalence and tolerability assessment of a novel intravenous ciclosporin lipid emulsion compared to branded ciclosporin in Cremophor ® EL.
Topics: Adolescent; Adult; Area Under Curve; Biological Availability; Chemistry, Pharmaceutical; Cross-Over Studies; Cyclosporine; Emulsifying Agents; Excipients; Fat Emulsions, Intravenous; Female; Glycerol; Half-Life; Humans; Immunosuppressive Agents; Infusions, Intravenous; Male; Metabolic Clearance Rate; Middle Aged; South Africa; Therapeutic Equivalency; Young Adult | 2013 |
Effects of Cremophor EL on the absorption of orally administered saquinavir and fexofenadine in healthy subjects.
Topics: Absorption, Physiological; Administration, Oral; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cross-Over Studies; Cytochrome P-450 CYP3A; Excipients; Glycerol; Healthy Volunteers; Humans; Male; Saquinavir; Substrate Specificity; Terfenadine | 2015 |
343 other study(ies) available for cremophor el and glycerol
| Article | Year |
|---|---|
[Possibility of damage to blood vessel walls due to intravenous anesthetics. Clinical and experimental study].
Topics: Adult; Alfaxalone Alfadolone Mixture; Anesthesia, Intravenous; Anesthetics; Animals; Atropine; Blood Vessels; Castor Oil; Diazepam; Female; Glycerol; Humans; Phlebitis; Preanesthetic Medication; Propanidid; Rabbits; Thrombophlebitis; Thrombosis; Vascular Diseases | 1979 |
Actions of cyclosporin A preparation and Cremophor-EL in rabbit mesenteric artery and thoracic aorta in vitro.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Cyclosporine; Drug Synergism; Glycerol; In Vitro Techniques; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; Phenylephrine; Rabbits; Solvents; Vasoconstriction; Vasodilation | 1992 |
The distribution of the tumour photosensitizers Zn(II)-phthalocyanine and Sn(IV)-etiopurpurin among rabbit plasma proteins.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Animals; Blood Proteins; Emulsions; Glycerol; Indoles; Isoindoles; Lipoproteins; Liposomes; Organometallic Compounds; Pharmaceutical Vehicles; Porphyrins; Rabbits; Radiation-Sensitizing Agents; Zinc Compounds | 1992 |
Properties of cremophor EL micelles probed by fluorescence.
Topics: Anilino Naphthalenesulfonates; Animals; Biological Transport; Daunorubicin; Fluorescence Polarization; Fluorescent Dyes; Glycerol; Leukemia P388; Mice; Micelles; Spectrometry, Fluorescence; Surface-Active Agents; Tumor Cells, Cultured | 1992 |
Acute effects of cyclosporin and cremophor EL on endothelial function and vascular smooth muscle in the isolated rat heart.
Topics: Animals; Coronary Circulation; Cyclosporine; Endothelium, Vascular; Glycerol; Heart; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Perfusion; Pharmaceutical Vehicles; Rats; Rats, Inbred Strains | 1992 |
Emulsifier for intravenous cyclosporin inhibits neurite outgrowth, causes deficits in rapid axonal transport and leads to structural abnormalities in differentiating N1E.115 neuroblastoma.
Topics: Animals; Cell Differentiation; Cyclosporine; Glycerol; Mice; Neurites; Neuroblastoma; Pharmaceutical Vehicles; Tumor Cells, Cultured; Video Recording | 1992 |
Reversal of multidrug resistance by surfactants.
Topics: Animals; Biological Transport; Bone Marrow; Cell Line; Cell Survival; Daunorubicin; Doxorubicin; Drug Resistance; Glycerol; Humans; Leukemia P388; Membrane Fluidity; Mice; Mice, Inbred DBA; Mice, Inbred Strains; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Surface-Active Agents; Tumor Cells, Cultured | 1992 |
P-glycoprotein drug efflux pump involved in the mechanisms of intrinsic drug resistance in various colon cancer cell lines. Evidence for a saturation of active daunorubicin transport.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Biological Transport, Active; Cell Survival; Colonic Neoplasms; Daunorubicin; Drug Resistance; Female; Glycerol; Humans; Membrane Glycoproteins; Mice; Neoplasm Proteins; Ovarian Neoplasms; RNA, Messenger; Tumor Cells, Cultured; Verapamil | 1991 |
Intracellular calcium concentration of acinar cells in feline tracheal submucosal glands.
Topics: Animals; Calcium; Cats; Detergents; Exocrine Glands; Glycerol; Glycoproteins; In Vitro Techniques; Kinetics; Methacholine Chloride; Mucus; Muscle, Smooth; Phenylephrine; Substance P; Trachea; Vasoactive Intestinal Peptide | 1990 |
Cremophor EL as an adjuvant affecting immunoglobulin class switch in the immune response to the thymus-independent antigen alpha(1- greater than 3) dextran B 1355 S.
Topics: Adjuvants, Immunologic; Animals; Antigens, T-Independent; Dextrans; Glycerol; Immunoglobulin G; Immunoglobulin M; Isoelectric Focusing; Mice; Mice, Inbred BALB C | 1991 |
The influence of the cyclosporine vehicle, cremophor EL, on renal microvascular blood flow in the rat.
Topics: Animals; Blood Pressure; Cardiac Output; Cyclosporins; Glycerol; Heart Rate; Male; Pharmaceutical Vehicles; Rats; Rats, Inbred Strains; Renal Artery; Renal Circulation; Ultrasonics; Vascular Resistance; Vasoconstriction | 1991 |
The solvents cremophor EL and Tween 80 modulate daunorubicin resistance in the multidrug resistant Ehrlich ascites tumor.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Carcinoma, Ehrlich Tumor; Cyclosporins; Daunorubicin; Dihydropyridines; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Glycerol; Humans; Intracellular Membranes; Membrane Glycoproteins; Polysorbates; Tritium; Tumor Cells, Cultured; Verapamil | 1990 |
Mechanism of clastogenic and co-clastogenic activity of cremophore with benzene in mice.
Topics: Animals; Benzene; Biotransformation; Cytochrome P-450 Enzyme System; Drug Synergism; Enzyme Induction; Glycerol; Male; Mice; Mice, Inbred ICR; Micronucleus Tests; Mutagens; Praziquantel; Solvents | 1991 |
The hemodynamic effects of Cremophor-EL.
Topics: Animals; Blood Pressure; Cardiac Output; Dogs; Glycerol; Hemodynamics; Infusions, Intravenous; Kidney; Liver; Pancreas; Regional Blood Flow; Verapamil | 1991 |
Interaction of cremophor EL with human plasma.
Topics: Emulsions; Glycerol; Humans; In Vitro Techniques; Lipoproteins, HDL; Lipoproteins, LDL; Lipoproteins, VLDL; Pharmaceutical Vehicles; Protein Binding | 1991 |
The polyoxyethylene castor oil Cremophor EL modifies multidrug resistance.
Topics: Cyclosporins; Doxorubicin; Drug Resistance; Glycerol; Humans; Solvents; Tumor Cells, Cultured; Vincristine | 1990 |
Cyclosporin A and vehicle toxicity in primary cultures of rabbit renal proximal tubule cells.
Topics: Amiloride; Animals; Arginine Vasopressin; Cell Membrane; Cell Survival; Cells, Cultured; Colforsin; Cyclosporins; Glycerol; Kidney Tubules, Proximal; Kinetics; Microscopy, Electron; Microscopy, Electron, Scanning; Ouabain; Parathyroid Hormone; Pharmaceutical Vehicles; Rabbits | 1990 |
Modulation of histamine release by fatty acids. A new in vitro model investigating adverse drug reactions in various species.
Topics: Alfaxalone Alfadolone Mixture; Anesthetics; Animals; Dogs; Fatty Acids; Female; Glycerol; Guinea Pigs; Histamine; Histamine Release; Humans; In Vitro Techniques; Male; Mast Cells; Propanidid; Rats | 1985 |
Comparison of the histamine-releasing activity of cremophor E1 and some of its derivatives in two experimental models: the in vivo anaesthetized dog and in vitro rat peritoneal mast cells.
Topics: Animals; Dogs; Female; Glycerol; Histamine Release; Hypotension; In Vitro Techniques; Male; Mast Cells; Rats; Rats, Inbred Strains; Species Specificity; Stearic Acids; Surface-Active Agents | 1985 |
Modulation of histamine release from rat peritoneal mast cells by non-cytotoxic concentrations of the detergents Cremophor El (oxethylated castor oil) and Triton X100. A possible explanation for unexpected adverse drug reactions?
Topics: Animals; Calcimycin; Drug Hypersensitivity; Female; Glycerol; Histamine Release; Mast Cells; Octoxynol; p-Methoxy-N-methylphenethylamine; Peritoneal Cavity; Polyethylene Glycols; Rats; Rats, Inbred Strains | 1986 |
Isolation of mast cells from rabbit lung and liver: comparison of histamine release induced by the hypnotics Althesin and propanidid.
Topics: Alfaxalone Alfadolone Mixture; Animals; Cell Separation; Detergents; Ethylene Oxide; Glycerol; Histamine Release; In Vitro Techniques; Liver; Lung; Mast Cells; Organ Specificity; Propanidid; Rabbits; Stearic Acids | 1987 |
Reversibility of acute cyclosporin nephrotoxicity by dopamine. Micropuncture study in the rat.
Topics: Animals; Cyclosporins; Dopamine; Female; Glomerular Filtration Rate; Glycerol; Infusions, Intravenous; Kidney Failure, Chronic; Pharmaceutical Vehicles; Rats; Rats, Inbred Strains | 1989 |
Schistosoma mansoni: experimental chemoprophylaxis in mice using oral anti-penetration agents.
Topics: Administration, Oral; Animals; Castor Oil; Glycerol; Mice; Mice, Inbred ICR; Polyethylene Glycols; Praziquantel; Propylene Glycols; Schistosoma mansoni; Schistosomiasis mansoni; Surface-Active Agents | 1989 |
Encephalopathy associated with fat embolism induced by solvent for cyclosporin.
Topics: Brain Diseases; Cyclosporins; Embolism, Fat; Glycerol; Humans; Solvents | 1989 |
Influence of the rate of infusion on cyclosporine nephrotoxicity in the rat.
Topics: Animals; Blood Pressure; Capillaries; Cyclosporins; Glycerol; Infusions, Intravenous; Injections, Intraperitoneal; Kidney; Male; Polysorbates; Rats; Rats, Inbred Strains; Renal Circulation; Solvents; Time Factors; Vascular Resistance | 1989 |
Cholestasis in the rat by means of intravenous administration of cyclosporine vehicle, Cremophor EL.
Topics: Animals; Bile Acids and Salts; Bilirubin; Cholestasis; Cyclosporins; Glycerol; Pharmaceutical Vehicles; Rats; Secretory Rate | 1989 |
Cremophor EL, a widely used parenteral vehicle, is a potent inhibitor of protein kinase C.
Topics: Binding, Competitive; Cell Line; DNA Polymerase II; Drug Carriers; Glycerol; Humans; Kinetics; Leukemia; Phorbol 12,13-Dibutyrate; Protein Binding; Protein Kinase C; Protein Kinases; RNA Polymerase II; Solvents; Tetradecanoylphorbol Acetate | 1989 |
Pulmonary changes in rats following administration of 3-methylindole in cremophore EL.
Topics: Animals; Bronchiolitis; Glycerol; Lung; Male; Pharmaceutical Vehicles; Rats; Rats, Inbred Strains; Skatole | 1988 |
Cyclosporine's effect on canine pancreatic endocrine function.
Topics: Administration, Oral; Animals; Cyclosporins; Dogs; Drug Administration Schedule; Female; Glucose Tolerance Test; Glycerol; Infusions, Intravenous; Insulin; Islets of Langerhans | 1988 |
An inert mixture for solubilizing lipophilic drugs in cell culture assays.
Topics: Animals; Cells, Cultured; Fibroblasts; Glycerol; Melanoma, Experimental; Microscopy, Electron | 1987 |
Use of the isolated perfused kidney model to assess the acute pharmacologic effects of cyclosporine and its vehicle, cremophor EL.
Topics: Animals; Cyclosporins; Glomerular Filtration Rate; Glycerol; Kidney; Male; Methanol; Perfusion; Pharmaceutical Vehicles; Rats; Regional Blood Flow; Solubility; Time Factors; Vascular Resistance | 1987 |
Anaphylactic reaction to first exposure to cyclosporine.
Topics: Adult; Anaphylaxis; Cyclosporins; Female; Glycerol; Humans | 1986 |
Leaching of diethylhexyl phthalate from polyvinyl chloride bags into intravenous cyclosporine solution.
Topics: Cyclosporins; Diethylhexyl Phthalate; Drug Contamination; Drug Packaging; Glycerol; Infusions, Intravenous; Phthalic Acids; Polyvinyl Chloride; Polyvinyls | 1986 |
Acute nephrotoxicity following intravenous cyclosporine.
Topics: Animals; Cyclosporins; Glomerular Filtration Rate; Glycerol; Kidney; Male; Perfusion; Pharmaceutical Vehicles; Rats; Rats, Inbred Strains; Renal Circulation | 1987 |
The effects of cremophor EL in the anaesthetized dog.
Topics: Animals; Biogenic Amines; Blood Cell Count; Blood Volume; Catecholamines; Dogs; Glycerol; Hemodynamics; Histamine; Lung Compliance; Male; Pulmonary Circulation; Solvents | 1987 |
Pharmacology of an emulsion formulation of ICI 35868.
Topics: Anesthetics; Animals; Fat Emulsions, Intravenous; Glycerol; Male; Mice; Phenols; Propofol; Therapeutic Equivalency | 1985 |
Anaphylactoid reactions associated with parenteral cyclosporine use: possible role of Cremophor EL.
Topics: Adult; Anaphylaxis; Cyclosporins; Drug Hypersensitivity; Excipients; Female; Glycerol; Humans; Male | 1985 |
Antidiuretic effects of cremophor EL in rats.
Topics: Animals; Castor Oil; Chemical Phenomena; Chemistry; Diuresis; Diuretics; Ethylene Oxide; Female; Glycerol; Male; Potassium; Rats; Rats, Inbred Strains; Sodium; Surface-Active Agents; Uric Acid | 1971 |
Potential hazards of prolonged steroid anaesthesia.
Topics: Alfaxalone Alfadolone Mixture; Edema; Female; Glycerol; Humans; Male; Middle Aged; Time Factors | 1983 |
Histamine release and hypotensive reactions in dogs by solubilizing agents and fatty acids: analysis of various components in cremophor El and development of a compound with reduced toxicity.
Topics: Animals; Blood Pressure; Castor Oil; Child; Child, Preschool; Dogs; Fatty Acids; Female; Glycerol; Histamine; Histamine Release; Humans; Infant; Male; Solvents; Stearic Acids | 1982 |
Functional heterogeneity of mast cells from different species and tissues.
Topics: Anaphylatoxins; Animals; Dextrans; Glycerol; Histamine Release; Humans; Mast Cells; p-Methoxy-N-methylphenethylamine; Peptides; Polysorbates; Povidone; Species Specificity | 1982 |
Pharmacology of an emulsion formulation of ICI 35 868.
Topics: Anaphylaxis; Anesthetics; Animals; Behavior, Animal; Chemistry, Pharmaceutical; Dogs; Emulsions; Female; Glycerol; Hemodynamics; Histamine Release; Leukocyte Count; Male; Mice; Neutrophils; Phenols; Propofol; Rats; Solvents; Swine; Time Factors | 1984 |
Blood viscosity and blood film morphology during prolonged sedation with Althesin.
Topics: Alfaxalone Alfadolone Mixture; Blood Cells; Blood Viscosity; Glycerol; Humans; Hypnotics and Sedatives | 1984 |
Role of metabolism in the immediate effects and pneumotoxicity of 3-methylindole in goats.
Topics: Animals; Biotransformation; Female; Glycerol; Goats; Hemolysis; Indoles; Infusions, Parenteral; Lung Diseases; Male; Mixed Function Oxygenases; Phenobarbital; Piperonyl Butoxide; Skatole | 1984 |
Adjuvancy of Cremophor Elo in rodents.
Topics: Adjuvants, Immunologic; Animals; Drug Hypersensitivity; Female; Glycerol; Guinea Pigs; Hypersensitivity, Delayed; Male; Mice; Pregnanediones; Serum Albumin, Bovine | 1983 |
Anaphylaxis caused by anti-cremophor EL IgG STS antibodies in a case of reaction to althesin.
Topics: Adolescent; Alfaxalone Alfadolone Mixture; Anaphylaxis; Anesthesia, Intravenous; Female; Glycerol; Humans; Immunoglobulin G; Intraoperative Complications; Solvents | 1983 |
Assessment of the allergenic potential of althesin and its constituents.
Topics: Alfaxalone Alfadolone Mixture; Anesthetics; Animals; Drug Hypersensitivity; Female; Glycerol; Guinea Pigs; Intradermal Tests; Male; Pregnanediones | 1983 |
Case report--suspected anaphylactic reaction to Cremophor El.
Topics: Adolescent; Anaphylaxis; Castor Oil; Female; Glycerol; Humans; Solvents; Surface-Active Agents | 1981 |
A haemorheological study of althesin.
Topics: Adult; Alfaxalone Alfadolone Mixture; Anesthesia, Intravenous; Anesthetics; Blood Viscosity; Female; Glycerol; Humans; Male; Pregnanediones; Solvents | 1982 |
Epidemiology of adverse reactions in anaesthesia in the United Kingdom.
Topics: Adjuvants, Anesthesia; Anesthetics; Drug Hypersensitivity; Glycerol; Humans; Neuromuscular Blocking Agents; United Kingdom | 1982 |
Genotoxicity of N-methyl-N-nitrosourea in the presence of amphiphilic membrane-active compounds.
Topics: Animals; Bromodeoxyuridine; Castor Oil; Cells, Cultured; Cricetinae; Drug Interactions; Glycerol; Membranes; Methylnitrosourea; Mutagens; Nitrosourea Compounds; Sister Chromatid Exchange | 1981 |
Suspected anaphylactic reaction to Cremophor EL.
Topics: Adolescent; Alfaxalone Alfadolone Mixture; Anaphylaxis; Antibody Formation; Castor Oil; Complement C4; Female; Glycerol; Humans; Immunologic Memory; Propanidid; Surface-Active Agents | 1980 |
Differential modulation of P-glycoprotein, the multidrug resistance mediator, by Cremophor in normal versus leukemic hematopoietic cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporins; Drug Resistance, Multiple; Glycerol; Humans; In Vitro Techniques; Leukemia, Myeloid, Acute; Lymphocytes; Pharmaceutical Vehicles | 1995 |
PEG-coated poly(lactic acid) nanoparticles for the delivery of hexadecafluoro zinc phthalocyanine to EMT-6 mouse mammary tumours.
Topics: Animals; Colloids; Delayed-Action Preparations; Emulsions; Glycerol; Indoles; Injections, Intravenous; Lactates; Lactic Acid; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Microspheres; Organometallic Compounds; Photochemotherapy; Polyesters; Polyethylene Glycols; Polymers; Radiation-Sensitizing Agents; Solvents; Tissue Distribution | 1995 |
Effects of polysorbates and Cremophor EL on vascular responses in rat aorta.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Bradykinin; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Glycerol; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroprusside; Phenylephrine; Polysorbates; Rats; Serotonin; Surface-Active Agents | 1995 |
Interaction of drugs with P-glycoprotein in brain capillaries.
Topics: Affinity Labels; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Blood-Brain Barrier; Brain; Capillaries; Cyclosporine; Cyclosporins; Drug Interactions; Glycerol; In Vitro Techniques; Iodine Radioisotopes; Male; Prazosin; Rats; Rats, Sprague-Dawley; Time Factors; Tritium | 1995 |
Pediatric intravenous FK506--how much are we really infusing?
Topics: Adsorption; Child; Glycerol; Humans; Infusions, Intravenous; Liver Transplantation; Polyethylenes; Polyvinyl Chloride; Serum Albumin; Solvents; Syringes; Tacrolimus | 1994 |
Comparison of solutol HS 15, Cremophor EL and novel ethoxylated fatty acid surfactants as multidrug resistance modification agents.
Topics: Antineoplastic Agents; Cell Line; Drug Resistance, Multiple; Glycerol; Humans; Polyethylene Glycols; Rhodamine 123; Rhodamines; Stearic Acids; Surface-Active Agents | 1995 |
Binding of etiopurpurin to human plasma proteins. Delivery in cremophor EL and dimethyl sulphoxide. III.
Topics: Adsorption; Blood Proteins; Dimethyl Sulfoxide; Drug Delivery Systems; Fluorescence; Glycerol; Humans; In Vitro Techniques; Porphyrins; Protein Binding; Radiation-Sensitizing Agents; Time Factors; Ultracentrifugation | 1995 |
Interactions of Solutol HS 15 and Cremophor EL with plasma lipoproteins.
Topics: Animals; Blood Protein Electrophoresis; Blood Proteins; Centrifugation, Density Gradient; Glycerol; Humans; Lipoproteins; Lipoproteins, HDL; Lipoproteins, LDL; Mice; Molecular Structure; Photosensitizing Agents; Polyethylene Glycols; Porphyrins; Protein Binding; Stearic Acids; Surface-Active Agents | 1995 |
Comparison of cyclosporin A, verapamil, PSC-833 and cremophor EL as enhancing agents of VP-16 in murine lymphoid leukemias.
Topics: Animals; Cell Survival; Cyclosporine; Cyclosporins; Drug Synergism; Etoposide; Glycerol; Leukemia L1210; Leukemia P388; Mice; Survival Analysis; Tumor Cells, Cultured; Verapamil | 1995 |
The effect of indomethacin on cyclosporin A- and its solvent-induced inhibition of endothelium-dependent relaxation and the drug-induced contraction of rabbit isolated arteries.
Topics: Acetylcholine; Animals; Cyclosporine; Endothelium, Vascular; Glycerol; In Vitro Techniques; Indomethacin; Male; Pharmaceutical Vehicles; Rabbits; Vasoconstriction; Vasodilation | 1995 |
Binding of etiopurpurin and tin-coordinated etiopurpurin to human plasma proteins. Delivery in cremophore EL and dimethyl sulfoxide (paper II).
Topics: Blood Proteins; Centrifugation, Density Gradient; Dimethyl Sulfoxide; Drug Carriers; Glycerol; Humans; Lipoproteins; Pharmaceutical Vehicles; Porphyrins; Protein Binding; Radiation-Sensitizing Agents; Spectrometry, Fluorescence | 1995 |
Metabolism of taxol by human and rat liver in vitro: a screen for drug interactions and interspecies differences.
Topics: Animals; Biotransformation; Cimetidine; Cytochrome P-450 Enzyme System; Dexamethasone; Diphenhydramine; Drug Evaluation, Preclinical; Drug Interactions; Glycerol; Humans; In Vitro Techniques; Ketoconazole; Kinetics; Liver; Microsomes, Liver; Paclitaxel; Quinidine; Rats; Species Specificity; Surface-Active Agents; Taxoids; Tritium | 1995 |
Reversal of C1300 murine neuroblastoma multidrug resistance by cremophorEL, a solvent for cyclosporin A.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Division; Chromatography, High Pressure Liquid; Clone Cells; Cyclosporine; Doxorubicin; Drug Interactions; Drug Resistance, Multiple; Glycerol; Harringtonines; Homoharringtonine; Intracellular Fluid; Mice; Neuroblastoma; Pharmaceutical Vehicles; Solvents; Tumor Cells, Cultured | 1993 |
Haematopoietic radioprotection by Cremophor EL: a polyethoxylated castor oil.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Castor Oil; Clone Cells; Colony-Forming Units Assay; Female; Flow Cytometry; Glycerol; Growth Substances; Hematopoiesis; Hematopoietic Stem Cells; Humans; Interleukin-1; Interleukin-6; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Platelet Count; Pregnancy; Radiation-Protective Agents; Recombinant Proteins; Reference Values; Reticulocyte Count; Salmonella typhi; Time Factors | 1995 |
The cytotoxic activity of Taxol in primary cultures of tumour cells from patients is partly mediated by Cremophor EL.
Topics: Antineoplastic Agents; Drug Screening Assays, Antitumor; Drug Synergism; Fluorometry; Glycerol; Humans; Kinetics; Neoplasms; Paclitaxel; Solvents; Tumor Cells, Cultured | 1995 |
Effect of the delivery system on the biodistribution of Ge(IV) octabutoxy-phthalocyanines in tumour-bearing mice.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Animals; Disease Models, Animal; Drug Carriers; Emulsions; Female; Glycerol; Indoles; Liposomes; Liver; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Organometallic Compounds; Photosensitizing Agents; Spleen; Tissue Distribution | 1995 |
Cremophor EL, solvent for paclitaxel, and toxicity.
Topics: Adenocarcinoma; Cell Division; Glycerol; Humans; Paclitaxel; Solvents; Tumor Cells, Cultured | 1993 |
Cytotoxic studies of paclitaxel (Taxol) in human tumour cell lines.
Topics: Adenocarcinoma; Astrocytoma; Breast Neoplasms; Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Drug; Female; Glycerol; HeLa Cells; Humans; Lung Neoplasms; Ovarian Neoplasms; Paclitaxel; Pancreatic Neoplasms; Tumor Cells, Cultured; Uterine Cervical Neoplasms | 1993 |
The influence of Cremophor EL on the cell cycle effects of paclitaxel (Taxol) in human tumor cell lines.
Topics: Adenocarcinoma; Breast Neoplasms; Cell Cycle; DNA, Neoplasm; Female; Flow Cytometry; Glycerol; Humans; Lung Neoplasms; Mitotic Index; Paclitaxel; Pharmaceutical Vehicles; Photography; Tumor Cells, Cultured | 1994 |
[Study for modifying activity of solvents on antitumor activity of paclitaxel].
Topics: Animals; Cell Division; Dimethyl Sulfoxide; Doxorubicin; Drug Resistance; Glycerol; Leukemia P388; Male; Mice; Paclitaxel; Solvents; Tumor Cells, Cultured; Vincristine | 1994 |
Paclitaxel-induced cytotoxicity--the effects of cremophor EL (castor oil) on two human breast cancer cell lines with acquired multidrug resistant phenotype and induced expression of the permeability glycoprotein.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Carrier Proteins; Cell Survival; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance; Drug Screening Assays, Antitumor; Drug Synergism; Ethanol; Female; Glycerol; Humans; Membrane Glycoproteins; Neoplasm Proteins; Paclitaxel; Phenotype; Solvents; Tumor Cells, Cultured | 1994 |
Effects of Cremophor EL on distribution of Taxol to serum lipoproteins.
Topics: Centrifugation, Density Gradient; Drug Interactions; Electrophoresis; Glycerol; Humans; Infusions, Intravenous; Lipoproteins, HDL; Lipoproteins, LDL; Paclitaxel; Pharmaceutical Vehicles; Protein Binding; Serum Albumin; Solvents; Tissue Distribution; Ultracentrifugation | 1994 |
Analysis of exposure times and dose escalation of paclitaxel in ovarian cancer cell lines.
Topics: Cell Cycle; Cell Division; Dimethyl Sulfoxide; Drug Carriers; Drug Screening Assays, Antitumor; Female; Glycerol; Humans; Ovarian Neoplasms; Paclitaxel; Time Factors; Tumor Cells, Cultured | 1994 |
Novel taxol formulations: preparation and characterization of taxol-containing liposomes.
Topics: Animals; Cell Division; Cell Line; Drug Carriers; Drug Stability; Drug Storage; Electrochemistry; Female; Glycerol; Humans; Liposomes; Mice; Mice, Inbred BALB C; Paclitaxel; Pharmaceutical Vehicles; Phosphatidylcholines; Phosphatidylglycerols | 1994 |
Direct vasoconstrictor effects of sandimmune (cyclosporine A) are mediated by its vehicle cremophor EL: inhibition by the thromboxane A2/prostaglandin endoperoxide receptor antagonist ifetroban.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cyclosporine; Dose-Response Relationship, Drug; Glyburide; Glycerol; In Vitro Techniques; Male; Oxazoles; Pharmaceutical Vehicles; Propionates; Rabbits; Receptors, Thromboxane; Ricinoleic Acids; Vasoconstrictor Agents | 1994 |
Biodistribution of O6-benzylguanine and its effectiveness against human brain tumor xenografts when given in polyethylene glycol or cremophor-EL.
Topics: Adjuvants, Pharmaceutic; Animals; Antineoplastic Agents; Carmustine; Child; Chromatography, High Pressure Liquid; Female; Glioblastoma; Glycerol; Guanine; Humans; Injections, Intraperitoneal; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Polyethylene Glycols; Solubility; Tissue Distribution | 1994 |
The alteration of plasma lipoproteins by cremophor EL.
Topics: Animals; Electrophoresis, Polyacrylamide Gel; Female; Glycerol; Humans; Lipoproteins; Mesoporphyrins; Mice; Mice, Inbred C3H; Neoplasms, Experimental; Surface-Active Agents | 1994 |
Inhibition of erythrocyte glutathione conjugate transport by polyethoxylated surfactants.
Topics: Adenosine Triphosphate; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Cell Membrane; Drug Resistance; Erythrocytes; Female; Glutathione; Glycerol; Humans; Male; Membrane Glycoproteins; Surface-Active Agents | 1993 |
Is Cremophor EL, solvent for paclitaxel, cytotoxic?
Topics: Breast Neoplasms; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance; Glycerol; Humans; Paclitaxel; Solvents; Tumor Cells, Cultured | 1993 |
Measurement of cremophor EL following taxol: plasma levels sufficient to reverse drug exclusion mediated by the multidrug-resistant phenotype.
Topics: Adult; Aged; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Assay; Carrier Proteins; Drug Resistance; Female; Flow Cytometry; Glycerol; Humans; Membrane Glycoproteins; Middle Aged; Neoplasm Proteins; Ovarian Neoplasms; Paclitaxel; Pharmaceutical Vehicles; Phenotype; Tumor Cells, Cultured | 1993 |
Potential neurotoxicity of the solvent vehicle for cyclosporine.
Topics: Animals; Cyclosporine; Demyelinating Diseases; Ethanol; Female; Ganglia, Spinal; Glycerol; Humans; Nervous System; Pharmaceutical Vehicles; Pregnancy; Rats; Rats, Sprague-Dawley | 1994 |
Synergistic reversal of multidrug-resistance phenotype in acute myeloid leukemia cells by cyclosporin A and cremophor EL.
Topics: Cell Survival; Cyclosporine; Daunorubicin; Drug Resistance; Drug Synergism; Female; Glycerol; Humans; Leukemia, Myeloid, Acute; Male; Tumor Cells, Cultured | 1994 |
Assay of succinate dehydrogenase activity by a colorimetric-continuous method using iodonitrotetrazolium chloride as electron acceptor.
Topics: Animals; Azides; Buffers; Colorimetry; Female; Glycerol; Hydrogen-Ion Concentration; Kinetics; Mitochondria, Liver; Oxidation-Reduction; Phosphorylation; Potassium Cyanide; Rats; Rats, Sprague-Dawley; Rotenone; Sodium Azide; Succinate Dehydrogenase; Tetrazolium Salts | 1993 |
Dissolving intravenous cyclosporin A in a fat emulsion carrier prevents acute renal side effects in the rat.
Topics: Animals; Cyclosporine; Drug Carriers; Emulsions; Glomerular Filtration Rate; Glycerol; Infusions, Intravenous; Kidney; Kidney Diseases; Male; Rats; Rats, Wistar; Solubility; Soybean Oil | 1993 |
Ultrastructural neuropathologic effects of Taxol on neurons of the freshwater snail Lymnaea stagnalis.
Topics: Adrenocorticotropic Hormone; Animals; Anticonvulsants; Antineoplastic Agents, Phytogenic; Axons; Ganglia, Invertebrate; Glycerol; In Vitro Techniques; Lymnaea; Microscopy, Electron; Microtubules; Neurons; Paclitaxel; Peptide Fragments; Pharmaceutical Vehicles | 1995 |
Fractionation of Cremophor EL delineates components responsible for plasma lipoprotein alterations and multidrug resistance reversal.
Topics: Animals; Antineoplastic Agents; Biological Transport; Chemical Fractionation; Chromatography, High Pressure Liquid; Daunorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Electrophoresis, Agar Gel; Electrophoresis, Polyacrylamide Gel; Glycerol; Humans; Leukemia P388; Lipoproteins; Mice; Paclitaxel; Pharmaceutical Vehicles; Protein Binding | 1995 |
Effect of combination of suboptimal concentrations of P-glycoprotein blockers on the proliferation of MDR1 gene expressing cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Cell Division; Cell Membrane; Cyclosporins; Glycerol; Humans; Leukemia; Transfection; Tumor Cells, Cultured; Verapamil | 1996 |
Effect of the paclitaxel vehicle, Cremophor EL, on the pharmacokinetics of doxorubicin and doxorubicinol in mice.
Topics: Animals; Antibiotics, Antineoplastic; Doxorubicin; Female; Glycerol; Metabolic Clearance Rate; Mice; Mice, Inbred BALB C; Paclitaxel; Solvents; Time Factors | 1996 |
Inhibition of etoposide elimination in the isolated perfused rat liver by Cremophor EL and Tween 80.
Topics: Animals; Antineoplastic Agents, Phytogenic; Bile; Cholestasis; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Etoposide; Glycerol; Half-Life; Hemolysis; Liver; Male; Organ Culture Techniques; Perfusion; Polysorbates; Rats; Rats, Sprague-Dawley; Surface-Active Agents | 1996 |
Nonlinear pharmacokinetics of paclitaxel in mice results from the pharmaceutical vehicle Cremophor EL.
Topics: Animals; Antineoplastic Agents, Phytogenic; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Female; Glycerol; Humans; Mice; Paclitaxel; Pharmaceutical Vehicles; Solvents | 1996 |
Tenfold increased incidence of spontaneous multiple myeloma in long-term immunosuppressed aging C57BL/KaLwRij mice.
Topics: Aging; Animals; Antibody Specificity; Disease Susceptibility; Female; Glycerol; Immunoglobulin Isotypes; Immunoglobulins; Immunosuppression Therapy; Longevity; Mice; Mice, Inbred C57BL; Multiple Myeloma; Solvents | 1996 |
Photodynamic therapy of tumours with hexadecafluoro zinc phthalocynine formulated in PEG-coated poly(lactic acid) nanoparticles.
Topics: Animals; Biodegradation, Environmental; Coloring Agents; Drug Carriers; Emulsions; Glycerol; Indoles; Lactates; Lactic Acid; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Microspheres; Neoplasm Transplantation; Organometallic Compounds; Particle Size; Photochemotherapy; Polyesters; Polyethylene Glycols; Polymers; Radiation-Sensitizing Agents; Solubility; Suspensions; Thigh; Tumor Cells, Cultured | 1996 |
Anti-oxidants inhibit the enhancement of the immune response caused by oil adjuvants.
Topics: Adjuvants, Immunologic; Adult; Animals; Antibody Formation; Antioxidants; Catalase; Cytotoxicity Tests, Immunologic; Erythrocytes; Freund's Adjuvant; Glycerol; Humans; Hydrogen Peroxide; Hypersensitivity, Delayed; Immunity, Cellular; Mice; Mice, Inbred AKR; Mice, Inbred BALB C; Mice, Inbred DBA; Reactive Oxygen Species; Sheep | 1996 |
Determination of polyoxyethyleneglycerol triricinoleate 35 (Cremophor EL) in plasma by pre-column derivatization and reversed-phase high-performance liquid chromatography.
Topics: Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Ethanol; Female; Glycerol; Humans; Mice; Regression Analysis; Sensitivity and Specificity; Solvents; Water | 1996 |
Cyclosporine protects glomeruli from FSGS factor via an increase in glomerular cAMP.
Topics: Albumins; Animals; Cyclic AMP; Cyclosporine; Glomerulosclerosis, Focal Segmental; Glycerol; Humans; Kidney Glomerulus; Male; Microscopy, Electron; Permeability; Rats; Rats, Sprague-Dawley; Sodium Chloride | 1996 |
Cremophor EL reversed multidrug resistance in vitro but not in tumor-bearing mouse models.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporins; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Glycerol; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Surface-Active Agents; Tumor Cells, Cultured; Vincristine | 1996 |
Presynaptic modification of synaptic transmission at identified Aplysia central synapses, induced by changes in protein kinase C activity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aplysia; Electric Stimulation; Enzyme Activation; Enzyme Inhibitors; Evoked Potentials; Ganglia, Invertebrate; Glycerol; In Vitro Techniques; Naphthalenes; Neurons; Phorbol Esters; Presynaptic Terminals; Protein Kinase C; Sphingosine; Sulfonamides; Synapses; Synaptic Transmission | 1996 |
Differential activity of Cremophor EL and paclitaxel in patients' tumor cells and human carcinoma cell lines in vitro.
Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Glycerol; Humans; Paclitaxel; Surface-Active Agents; Tumor Cells, Cultured | 1997 |
The vehicle for cyclosporine is neurotoxic in vitro.
Topics: Animals; Axons; Cells, Cultured; Cyclosporine; Demyelinating Diseases; Glycerol; Humans; Neurons; Oligodendroglia; Pharmaceutical Vehicles | 1997 |
Proliferation, migration and invasion of human glioma cells exposed to paclitaxel (Taxol) in vitro.
Topics: Adult; Animals; Antineoplastic Agents, Phytogenic; Brain Neoplasms; Cell Division; Cell Movement; Female; Flow Cytometry; Glioblastoma; Glioma; Glycerol; Humans; Microscopy, Confocal; Paclitaxel; Rats; Rats, Wistar; Solvents; Spheroids, Cellular; Tumor Cells, Cultured | 1997 |
Effect of paclitaxel (Taxol) on CA 125 expression and release by ovarian cancer cell lines.
Topics: Antineoplastic Agents, Phytogenic; CA-125 Antigen; Cell Count; Cystadenocarcinoma, Serous; Female; Glycerol; Humans; Immunohistochemistry; Ovarian Neoplasms; Paclitaxel; Pharmaceutical Vehicles; Tumor Cells, Cultured | 1997 |
Mechanistic roles of neutral surfactants on concurrent polarized and passive membrane transport of a model peptide in Caco-2 cells.
Topics: Biological Transport; Biological Transport, Active; Caco-2 Cells; Diffusion; Glycerol; Humans; Micelles; Peptides; Permeability; Polysorbates; Surface Tension; Surface-Active Agents | 1997 |
Propofol pharmacokinetics and pharmacodynamics assessed from a cremophor EL formulation.
Topics: Anesthetics, Intravenous; Animals; Chromatography, High Pressure Liquid; Electroencephalography; Glycerol; Half-Life; Male; Pharmaceutical Vehicles; Propofol; Rats; Rats, Wistar | 1997 |
Pulmonary delivery of intratracheally instilled and aerosolized cyclosporine A to young and adult rats.
Topics: Aerosols; Aging; Animals; Biological Availability; Cyclosporine; Female; Glycerol; Half-Life; Lung; Male; Rats; Rats, Sprague-Dawley; Trachea | 1997 |
Differentiation of Malassezia species: selectivity of cremophor EL, castor oil and ricinoleic acid for M. furfur.
Topics: Castor Oil; Colony Count, Microbial; Emulsions; Esculin; Excipients; Glycerol; Humans; Malassezia; Mycological Typing Techniques; Ricinoleic Acids; Species Specificity | 1997 |
Effect of cyclosporine A on the release of tissue factor pathway inhibitor from endothelial cells in heart transplant patients and cell culture.
Topics: Adolescent; Adult; Calcimycin; Calcium; Cell Division; Cells, Cultured; Cyclosporine; Endothelium, Vascular; Female; Glycerol; Heart Transplantation; Humans; Ionophores; Lipoproteins; Male; Middle Aged; Pharmaceutical Vehicles; von Willebrand Factor | 1997 |
Mechanism of anaphylactoid reactions: improper preparation of high-dose intravenous cyclosporine leads to bolus infusion of Cremophor EL and cyclosporine.
Topics: Anaphylaxis; Chemistry, Pharmaceutical; Cyclosporine; Drug Compounding; Ethanol; Glycerol; Humans; Pharmaceutical Vehicles; Solutions | 1997 |
Differential modulation of cisplatin accumulation in leukocytes and tumor cell lines by the paclitaxel vehicle Cremophor EL.
Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Cisplatin; Drug Interactions; Glycerol; Humans; In Vitro Techniques; Leukocytes; Paclitaxel; Pharmaceutical Vehicles; Polyethylene Glycols; Polysorbates; Surface-Active Agents | 1997 |
Quantitation of Cremophor EL in human plasma samples using a colorimetric dye-binding microassay.
Topics: Antineoplastic Agents, Phytogenic; Calibration; Colorimetry; Coloring Agents; Female; Glycerol; Humans; Ovarian Neoplasms; Paclitaxel; Pilot Projects; Reproducibility of Results; Rosaniline Dyes; Surface-Active Agents | 1998 |
Cytotoxicity of fractionated paclitaxel (Taxol) administration in vitro.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line; Cell Survival; Cells, Cultured; Cricetinae; Cricetulus; DNA; Dose-Response Relationship, Drug; Ethanol; Flow Cytometry; Glycerol; Paclitaxel; Solvents; Time Factors | 1998 |
Complement activation by Cremophor EL as a possible contributor to hypersensitivity to paclitaxel: an in vitro study.
Topics: Antineoplastic Agents, Phytogenic; Complement Activation; Drug Hypersensitivity; Enzyme-Linked Immunosorbent Assay; Glycerol; Humans; In Vitro Techniques; Paclitaxel; Pharmaceutical Vehicles | 1998 |
Separation of paclitaxel and related taxanes by micellar electrokinetic capillary chromatography.
Topics: Acetonitriles; Chromatography; Glycerol; Micelles; Paclitaxel; Plant Extracts; Sodium Dodecyl Sulfate; Temperature; Thermodynamics | 1998 |
Paclitaxel hypersensitivity reactions: a role for docetaxel substitution.
Topics: Aged; Antineoplastic Agents, Phytogenic; Docetaxel; Drug Hypersensitivity; Female; Glycerol; Humans; Male; Middle Aged; Neoplasms; Paclitaxel; Taxoids | 1998 |
Influence of Cremophor EL on the quantification of paclitaxel in plasma using high-performance liquid chromatography with solid-phase extraction as sample pretreatment.
Topics: Antineoplastic Agents, Phytogenic; Chromatography, High Pressure Liquid; Evaluation Studies as Topic; Glycerol; Humans; Paclitaxel; Pharmaceutical Vehicles | 1998 |
Linearized colorimetric assay for cremophor EL: application to pharmacokinetics after 1-hour paclitaxel infusions.
Topics: Antineoplastic Agents, Phytogenic; Colorimetry; Glycerol; Humans; Paclitaxel; Pharmaceutical Vehicles; Reproducibility of Results | 1998 |
Disposition of Cremophor EL in humans limits the potential for modulation of the multidrug resistance phenotype in vivo.
Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Body Fluid Compartments; Cisplatin; Clinical Trials, Phase I as Topic; Doxorubicin; Drug Resistance, Multiple; Female; Glycerol; Humans; Infusions, Intravenous; Middle Aged; Neoplasms; Paclitaxel; Phenotype; Surface-Active Agents; Tissue Distribution | 1998 |
Cyclosporin A enhances paclitaxel toxicity against leukemia and respiratory epithelial cancers.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cyclosporine; Cytokines; Disease Models, Animal; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Glycerol; Growth Substances; Humans; Immunosuppressive Agents; Leukemia; Mice; Paclitaxel; Respiratory Tract Neoplasms; Survival Rate; Treatment Outcome; Tumor Cells, Cultured | 1997 |
Effect of Cremophor EL on the pharmacokinetics, antitumor activity and toxicity of doxorubicin in mice.
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Doxorubicin; Drug Synergism; Female; Glycerol; Heart Diseases; Mice; Surface-Active Agents; Tissue Distribution; Tumor Cells, Cultured | 1998 |
Inhibition of paclitaxel elimination in the isolated perfused rat liver by Cremophor EL.
Topics: Animals; Antineoplastic Agents, Phytogenic; Area Under Curve; Bile; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Glycerol; Half-Life; In Vitro Techniques; Liver; Male; Paclitaxel; Rats; Rats, Sprague-Dawley; Surface-Active Agents | 1999 |
Cremophor EL-mediated alteration of paclitaxel distribution in human blood: clinical pharmacokinetic implications.
Topics: Aged; Antineoplastic Agents, Phytogenic; Erythrocytes; Female; Glycerol; Humans; Micelles; Paclitaxel; Pharmaceutical Vehicles | 1999 |
The role of mast cell degranulation in ischaemia-reperfusion-induced mucosal injury in the small intestine.
Topics: Animals; Cell Degranulation; Dogs; Glycerol; Histamine; Histidine Decarboxylase; Hydrogen-Ion Concentration; Ileum; Intestinal Mucosa; Mast Cells; p-Methoxy-N-methylphenethylamine; Reperfusion Injury | 1999 |
Inhibitory effect of rose oil products on Helicobacter pylori growth in vitro: preliminary report.
Topics: Acyclic Monoterpenes; Cholagogues and Choleretics; Drug Combinations; Glycerol; Helicobacter Infections; Helicobacter pylori; Humans; Plant Extracts; Plants, Medicinal; Surface-Active Agents; Terpenes | 1999 |
Effects of paclitaxel with or without cremophor EL on cellular clonogenic survival and apoptosis.
Topics: Adenocarcinoma; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Squamous Cell; Cell Survival; Glycerol; Humans; Paclitaxel; Pharmaceutical Vehicles; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1999 |
Cremophor EL causes (pseudo-) non-linear pharmacokinetics of paclitaxel in patients.
Topics: Area Under Curve; Dialysis; Glycerol; Humans; Paclitaxel; Pharmaceutical Vehicles; Surface-Active Agents | 1999 |
Disposition of [G-(3)H]paclitaxel and cremophor EL in a patient with severely impaired renal function.
Topics: Aged; Antineoplastic Agents, Phytogenic; Chromatography, High Pressure Liquid; Female; Glycerol; Humans; Nephrosclerosis; Ovarian Neoplasms; Paclitaxel; Spectrophotometry, Ultraviolet | 1999 |
Lipid emulsions as a novel system to reduce the hemolytic activity of lytic agents: mechanism of the protective effect.
Topics: Adult; Emulsions; Erythrocytes; Glycerol; Hemolysis; Humans; In Vitro Techniques; Liposomes; Male; Micelles; Oleic Acid; Phospholipids; Polyethylene Glycols; Stearic Acids; Surface-Active Agents | 2000 |
Compatibility and stability of aplidine, a novel marine-derived depsipeptide antitumor agent, in infusion devices, and its hemolytic and precipitation potential upon i.v. administration.
Topics: Antineoplastic Agents; Chemical Precipitation; Chromatography, High Pressure Liquid; Depsipeptides; Diethylhexyl Phthalate; Drug Evaluation, Preclinical; Drug Stability; Ethanol; Glycerol; Hemolysis; Humans; Infusions, Intravenous; Materials Testing; Oligopeptides; Peptides, Cyclic; Polyvinyl Chloride; Surface-Active Agents; Time Factors | 1999 |
Preparation and characterization of pH-responsive polymeric micelles for the delivery of photosensitizing anticancer drugs.
Topics: Acrylamides; Animals; Antineoplastic Agents; Glycerol; Hydrogen-Ion Concentration; Indoles; Mammary Neoplasms, Experimental; Mice; Micelles; Organometallic Compounds; Particle Size; Photochemotherapy; Photosensitizing Agents; Polymethacrylic Acids; Solubility; Surface-Active Agents; Tumor Cells, Cultured; Water | 2000 |
Titrimetric determination of Cremophor EL in aqueous solutions and biofluids: part 2: ruggedness of the method with respect to biofluids.
Topics: Alcohols; Blood; Body Fluids; Edetic Acid; Excipients; Formaldehyde; Freezing; Glycerol; Humans; Hydrogen-Ion Concentration; Plasma; Reproducibility of Results; Sodium Fluoride; Sodium Hydroxide; Solutions; Surface-Active Agents; Temperature; Time Factors; Titrimetry; Urine | 1999 |
Differential alteration of cisplatin cytotoxicity and myelotoxicity by the paclitaxel vehicle cremophor EL.
Topics: Analysis of Variance; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Chemistry, Pharmaceutical; Cisplatin; Drug Interactions; Female; Glycerol; Mice; Pharmaceutical Vehicles; Surface-Active Agents; Tissue Distribution; Tumor Cells, Cultured | 2000 |
Acute cyclosporine A-induced nephrotoxicity: a rabbit model.
Topics: Acute Disease; Animals; Cyclosporine; Glycerol; Kidney; Kidney Diseases; Male; Rabbits; Renal Circulation; Surface-Active Agents | 2000 |
Effect of polyoxyl 35 castor oil and Polysorbate 80 on the intestinal absorption of digoxin in vitro.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cardiotonic Agents; Cyclosporine; Digoxin; Glycerol; In Vitro Techniques; Intestinal Absorption; Intestine, Small; L-Lactate Dehydrogenase; Micelles; Polysorbates; Rats; Surface-Active Agents | 2000 |
Cyclosporine A and cremophor EL induce contractions of human saphenous vein: involvement of thromboxane A2 receptor-dependent pathway.
Topics: Biphenyl Compounds; Cyclosporine; Fibrinolytic Agents; Glycerol; Heptanoic Acids; Humans; Immunosuppressive Agents; In Vitro Techniques; Lipoxygenase Inhibitors; Muscle Contraction; Muscle, Smooth, Vascular; Pharmaceutical Vehicles; Receptors, Thromboxane; Saphenous Vein | 2000 |
Determination of Cremophor EL in plasma after sample preparation with solid phase extraction and plasma protein precipitation.
Topics: Animals; Blood Proteins; Chemical Precipitation; Female; Glycerol; Rats; Rats, Sprague-Dawley | 2001 |
Modulation of radiation-induced organs toxicity by cremophor-el in experimental animals.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bone Marrow Cells; Cholesterol; Creatinine; Gamma Rays; Glutathione; Glycerol; Hyperlipidemias; Kidney; Liver; Male; Mice; Micronuclei, Chromosome-Defective; Rats; Rats, Wistar; Surface-Active Agents; Triglycerides; Tumor Cells, Cultured; Urea | 2001 |
Formation of complement-activating particles in aqueous solutions of Taxol: possible role in hypersensitivity reactions.
Topics: Antineoplastic Agents, Phytogenic; Complement Activation; Complement Membrane Attack Complex; Drug Hypersensitivity; Glycerol; Humans; Immunoglobulins, Intravenous; Micelles; Paclitaxel; Solutions | 2001 |
Induction of apoptosis in MDR1 expressing cells by daunorubicin with combinations of suboptimal concentrations of P-glycoprotein modulators.
Topics: 3T3 Cells; Animals; Antibiotics, Antineoplastic; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Division; Cyclosporins; Daunorubicin; Drug Combinations; Drug Interactions; G2 Phase; Glycerol; Mice; Verapamil | 2001 |
Analysis of ubidecarenone (CoQ10) aqueous samples using reversed phase liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Coenzymes; Drug Stability; Glycerol; Pharmaceutical Solutions; Reproducibility of Results; Solvents; Ubiquinone | 2001 |
Effects of three penetration enhancers on transcorneal permeation of cyclosporine.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Benzalkonium Compounds; Biological Availability; Biological Transport; Cornea; Cyclosporine; Dimethyl Sulfoxide; Glycerol; Humans; Immunosuppressive Agents; Middle Aged; Permeability; Pharmaceutical Vehicles | 2001 |
Residue mass plot and abundance plot: detection of isobaric interferences in DE-MALDI-TOF-mass spectra of complex polymer mixtures.
Topics: Chromatography, Ion Exchange; Glycerol; Mass Spectrometry; Molecular Structure; Polyethylene Glycols; Polymers; Ricinoleic Acids; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2001 |
Compatibility and stability of the investigational polypeptide marine anticancer agent kahalalide F in infusion devices.
Topics: Absorption; Animals; Antineoplastic Agents; Area Under Curve; Biocompatible Materials; Chromatography, High Pressure Liquid; Depsipeptides; Drug Evaluation, Preclinical; Drug Interactions; Drug Stability; Glycerol; Infusion Pumps; Infusions, Intravenous; Mollusk Venoms; Peptides; Time Factors | 2001 |
Modulation of cisplatin pharmacodynamics by Cremophor EL: experimental and clinical studies.
Topics: Animals; Antineoplastic Agents; Cisplatin; Dose-Response Relationship, Drug; Drug Interactions; Female; Glycerol; Hematologic Diseases; Humans; Infusions, Intravenous; Infusions, Parenteral; Mice; Neoplasm Recurrence, Local; Ovarian Neoplasms; Pharmaceutical Vehicles | 2002 |
Entrapment by Cremophor EL decreases the absorption of paclitaxel from the gut.
Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Female; Glycerol; Intestinal Absorption; Mice; Micelles; Paclitaxel | 2002 |
Separation and first structure elucidation of Cremophor EL-components by hyphenated capillary electrophoresis and delayed extraction-matrix assisted laser desorption/ionization-time of flight-mass spectrometry.
Topics: Calibration; Electrophoresis, Capillary; Glycerol; Molecular Structure; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2002 |
Pharmacodynamics of non-break weekly paclitaxel (Taxol) and pharmacokinetics of Cremophor-EL vehicle: results of a dose-escalation study.
Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Area Under Curve; Dose-Response Relationship, Drug; Female; Glycerol; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Neutropenia; Paclitaxel; Pharmaceutical Vehicles; Surface-Active Agents | 2002 |
Use of a cholesterol-rich emulsion that binds to low-density lipoprotein receptors as a vehicle for paclitaxel.
Topics: Animals; Antineoplastic Agents; Cell Division; Cholesterol; Drug Carriers; Drug Stability; Emulsions; Glycerol; Lethal Dose 50; Paclitaxel; Particle Size; Rats; Rats, Wistar; Receptors, LDL; Tumor Cells, Cultured | 2002 |
A population analysis of the pharmacokinetics of Cremophor EL using nonlinear mixed-effect modelling.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Carboplatin; Female; Glycerol; Humans; Infusions, Intravenous; Male; Middle Aged; Models, Biological; Neoplasms; Paclitaxel; Pharmaceutical Vehicles; Surface-Active Agents | 2002 |
Polyoxyethylene-Delta(9,11)-didehydrostearate and glycerol-polyoxyethylene-Delta(9,11)-didehydrostearate: two new components of the non-ionic emulsifier Cremophor EL.
Topics: Electrophoresis, Capillary; Glycerol; Polyethylene Glycols | 2002 |
Effects of nonionic surfactants on membrane transporters in Caco-2 cell monolayers.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Cadherins; Carrier Proteins; Cell Membrane Permeability; Dipeptides; Glycerol; Humans; Membrane Fluidity; Membrane Transport Modulators; Membrane Transport Proteins; Monocarboxylic Acid Transporters; Polyethylene Glycols; Polysorbates; Protein Kinase C; Rhodamine 123; Surface-Active Agents; Vitamin E | 2002 |
A comparison of commonly used polyethoxylated pharmaceutical excipients on their ability to inhibit P-glycoprotein activity in vitro.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Carbon Radioisotopes; Cell Line; Dogs; Excipients; Glycerol; Humans; Mannitol; Membrane Fluidity; Paclitaxel; Polyethylene Glycols; Polysorbates; Tritium | 2002 |
Comparative permeability of human and rabbit corneas to cyclosporin and tritiated water.
Topics: Animals; Benzalkonium Compounds; Cornea; Culture Techniques; Cyclosporine; Dimethyl Sulfoxide; Female; Frozen Sections; Glycerol; Humans; Immunosuppressive Agents; Male; Models, Biological; Permeability; Rabbits; Time Factors; Tritium; Water | 2002 |
Dosing sequence-dependent pharmacokinetic interaction of oxaliplatin with paclitaxel in the rat.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Area Under Curve; Biological Availability; Chromatography, High Pressure Liquid; Drug Interactions; Glycerol; In Vitro Techniques; Infusions, Intravenous; Leukocytes; Male; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2002 |
An alternative paclitaxel microemulsion formulation: hypersensitivity evaluation and pharmacokinetic profile.
Topics: Animals; Antineoplastic Agents, Phytogenic; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Drug Hypersensitivity; Emulsions; Female; Glycerol; Guinea Pigs; Male; Paclitaxel | 2003 |
Enhanced transport of a novel anti-HIV agent--cosalane and its congeners across human intestinal epithelial (Caco-2) cell monolayers.
Topics: Anti-HIV Agents; Aurintricarboxylic Acid; Biological Transport; Caco-2 Cells; Cyclodextrins; Glycerol; Humans; Permeability; Solubility | 2003 |
Antinociceptive effects of Cremophor EL orally administered to mice.
Topics: Administration, Oral; Analgesics; Animals; Castor Oil; Dipyrone; Glycerol; Male; Mice; Morphine; Pain Measurement | 2003 |
Increased penetration of paclitaxel into the brain by inhibition of P-Glycoprotein.
Topics: Acridines; Animals; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Chromatography, High Pressure Liquid; Clinical Trials as Topic; Cyclosporine; Cyclosporins; Dose-Response Relationship, Drug; Female; Glycerol; Mice; Mice, Knockout; Paclitaxel; Tetrahydroisoquinolines; Time Factors | 2003 |
Effects of nonionic surfactants on the physical stability of immunoglobulin G in aqueous solution during mechanical agitation.
Topics: Calorimetry, Differential Scanning; Chromatography, High Pressure Liquid; Drug Compounding; Drug Stability; Glycerol; Glycine; Hot Temperature; Immunoglobulin G; Molecular Weight; Polysorbates; Protein Denaturation; Sodium Chloride; Solutions; Surface Tension; Surface-Active Agents; Temperature | 2003 |
The effects of pluronics block copolymers and Cremophor EL on intestinal lipoprotein processing and the potential link with P-glycoprotein in Caco-2 cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Cell Survival; Dose-Response Relationship, Drug; Drug Combinations; Glycerol; Humans; Intestinal Mucosa; Lipoproteins; Poloxamer; Polymers | 2003 |
A high-throughput combinatorial approach for the discovery of a cremophor EL-free paclitaxel formulation.
Topics: Animals; Chemistry, Pharmaceutical; Combinatorial Chemistry Techniques; Dose-Response Relationship, Drug; Drug Compounding; Excipients; Glycerol; Male; Paclitaxel; Rats; Rats, Sprague-Dawley; Time Factors | 2003 |
Ultrastructural evidence of early endothelial damage in coronary arteries of rat cardiac allografts.
Topics: Animals; Aorta; Coronary Vessels; Cyclosporine; Disease Models, Animal; Endothelium, Vascular; Glycerol; Heart Transplantation; Immunosuppressive Agents; Male; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Pharmaceutical Vehicles; Rats; Rats, Inbred Lew; Silver Staining; Surface-Active Agents | 2003 |
Onycholysis secondary to multiple paclitaxel 1-hour infusions: possible role for its vehicle (Cremophor EL).
Topics: Antineoplastic Agents, Phytogenic; Area Under Curve; Breast Neoplasms; Drug Administration Schedule; Female; Glycerol; Humans; Infusions, Intravenous; Nail Diseases; Paclitaxel; Pharmaceutical Vehicles; Solvents; Surface-Active Agents | 2003 |
Development and validation of a method to determine the unbound paclitaxel fraction in human plasma.
Topics: Aged; Antineoplastic Agents, Phytogenic; Carbon Radioisotopes; Countercurrent Distribution; Glycerol; Hemofiltration; Humans; Male; Micelles; Paclitaxel; Protein Binding; Reproducibility of Results; Scintillation Counting; Serum Albumin; Solvents; Time Factors; Tritium | 2004 |
In vitro investigation on the impact of the surface-active excipients Cremophor EL, Tween 80 and Solutol HS 15 on the metabolism of midazolam.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cell Survival; Cells, Cultured; Culture Media; Cytochrome P-450 CYP3A; Drug Evaluation, Preclinical; Drug Interactions; Excipients; Glycerol; Hepatocytes; Male; Membrane Proteins; Microsomes, Liver; Midazolam; Polyethylene Glycols; Polysorbates; Rats; Rats, Wistar; Stearic Acids; Surface-Active Agents; Technology, Pharmaceutical | 2004 |
Bioactivation of self-immolative dendritic prodrugs by catalytic antibody 38C2.
Topics: Antibodies, Catalytic; Biotransformation; Cell Line, Tumor; Doxorubicin; Drug Carriers; Drug Design; Glycerol; Humans; Inhibitory Concentration 50; Prodrugs | 2004 |
Taxane-mediated antiangiogenesis in vitro: influence of formulation vehicles and binding proteins.
Topics: Angiogenesis Inhibitors; Animals; Aorta, Thoracic; Blood Proteins; Cell Division; Chemistry, Pharmaceutical; Docetaxel; Drug Interactions; Endothelium, Vascular; Excipients; Glycerol; Humans; In Vitro Techniques; Male; Neovascularization, Pathologic; Paclitaxel; Pharmaceutical Vehicles; Polysorbates; Protein Binding; Rats; Rats, Sprague-Dawley; Taxoids | 2004 |
Modulation of intestinal P-glycoprotein function by cremophor EL and other surfactants by an in vitro diffusion chamber method using the isolated rat intestinal membranes.
Topics: 3-O-Methylglucose; Animals; ATP Binding Cassette Transporter, Subfamily B; Biological Transport, Active; Carrier Proteins; Dialysis; Diffusion Chambers, Culture; Dipeptides; Fluorescent Dyes; Glycerol; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Intestines; Jejunum; Membranes; Micelles; Rats; Rats, Wistar; Rhodamine 123; Surface-Active Agents | 2004 |
Novel oral formulation of paclitaxel inhibits neointimal hyperplasia in a rat carotid artery injury model.
Topics: Administration, Oral; alpha-Tocopherol; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Carotid Artery Injuries; Carotid Stenosis; Catheterization; Cell Division; Ethylene Glycols; Glycerol; Hyperplasia; Infusions, Parenteral; Intestines; Linoleic Acids; Male; Models, Animal; Myocytes, Smooth Muscle; Paclitaxel; Pharmaceutical Vehicles; Polysorbates; Radiography; Rats; Rats, Sprague-Dawley; Recurrence; Surface-Active Agents; Tocopherols; Tunica Intima; Verapamil | 2004 |
Cremophor EL stimulates mitotic recombination in uvsH//uvsH diploid strain of Aspergillus nidulans.
Topics: Aspergillus nidulans; Crossing Over, Genetic; Diploidy; DNA-Binding Proteins; Fungal Proteins; Glycerol; Mitosis; Mutagenicity Tests; Surface-Active Agents | 2004 |
A HPLC validated assay of paclitaxel's related impurities in pharmaceutical forms containing Cremophor EL.
Topics: Chromatography, High Pressure Liquid; Drug Contamination; Glycerol; Paclitaxel; Pharmaceutical Preparations | 2004 |
Disposition kinetics of taxanes after intraperitoneal administration in rats and influence of surfactant vehicles.
Topics: Animals; Antineoplastic Agents, Phytogenic; Area Under Curve; Ascites; Docetaxel; Erythrocytes; Excipients; Female; Glycerol; In Vitro Techniques; Injections, Intraperitoneal; Paclitaxel; Permeability; Pharmaceutical Vehicles; Polysorbates; Rats; Surface-Active Agents; Taxoids; Time Factors; Tissue Distribution | 2004 |
Combination of local, nonviral IL12 gene therapy and systemic paclitaxel treatment in a metastatic breast cancer model.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma; Cell Line, Tumor; Combined Modality Therapy; Female; Genetic Therapy; Glycerol; Interleukin-12; Lipids; Lung Neoplasms; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Paclitaxel; Plasmids; Polyethyleneimine | 2004 |
Enhanced ileal absorption of a hydrophilic macromolecule, pentosan polysulfate sodium (PPS).
Topics: Animals; Biological Availability; Caco-2 Cells; Female; Glycerol; Humans; Ileum; Intestinal Absorption; Male; Mucins; Pentosan Sulfuric Polyester; Rats; Rats, Sprague-Dawley; Sodium Salicylate; Surface-Active Agents; Viscosity | 2004 |
Paclitaxel nanoparticles for the potential treatment of brain tumors.
Topics: Adjuvants, Pharmaceutic; Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Chemistry, Pharmaceutical; Fatty Alcohols; Glycerol; Humans; Inhibitory Concentration 50; Male; Nanostructures; Paclitaxel; Pharmaceutical Vehicles; Polyethylene Glycols; Polysorbates; Rats; Rats, Inbred F344; Technology, Pharmaceutical; Tritium | 2004 |
Cremophor EL augments the cytotoxicity of hydrogen peroxide in lymphocytes dissociated from rat thymus glands.
Topics: Animals; Cell Separation; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Flow Cytometry; Glutathione; Glycerol; Hydrogen Peroxide; In Vitro Techniques; Lymphocytes; Oxidative Stress; Pharmaceutical Vehicles; Rats; Rats, Wistar; Thymus Gland | 2004 |
Preparation and in vitro characterization of self-nanoemulsified drug delivery system (SNEDDS) of all-trans-retinol acetate.
Topics: Calorimetry, Differential Scanning; Caprylates; Chemistry, Pharmaceutical; Drug Delivery Systems; Emulsions; Excipients; Glycerides; Glycerol; Nanotechnology; Nephelometry and Turbidimetry; Particle Size; Solubility; Soybean Oil; Spectroscopy, Fourier Transform Infrared; Surface-Active Agents; Technology, Pharmaceutical; Tretinoin | 2004 |
Effect of melatonin on the malondialdehyde level of neutrophils in cyclosporine-treated rats.
Topics: Animals; Cyclosporine; Glycerol; Male; Malondialdehyde; Melatonin; Neutrophils; Rats; Rats, Sprague-Dawley | 2004 |
Development and characterization of a novel Cremophor EL free liposome-based paclitaxel (LEP-ETU) formulation.
Topics: Chemistry, Pharmaceutical; Drug Delivery Systems; Drug Stability; Drug Storage; Freeze Drying; Glycerol; Liposomes; Paclitaxel; Pharmaceutical Vehicles; Solvents | 2005 |
Population pharmacokinetics of orally administered paclitaxel formulated in Cremophor EL.
Topics: Absorption; Adult; Aged; Antineoplastic Agents, Phytogenic; Biological Availability; Dose-Response Relationship, Drug; Glycerol; Humans; Middle Aged; Paclitaxel; Pharmaceutical Vehicles; Surface-Active Agents | 2005 |
Response surface methodology for optimization and characterization of limonene-based coenzyme Q10 self-nanoemulsified capsule dosage form.
Topics: Capsules; Coenzymes; Cyclohexenes; Emulsions; Glycerol; Limonene; Models, Statistical; Nanostructures; Particle Size; Solvents; Terpenes; Ubiquinone | 2004 |
Cremophor EL releases cyclosporin A adsorbed on blood cells and blood vessels, and increases apparent plasma concentration of cyclosporin A.
Topics: Adsorption; Animals; Blood Cells; Blood Vessels; Cyclosporine; Glycerol; Male; Rats; Rats, Wistar | 2005 |
Micelles of methoxy poly(ethylene oxide)-b-poly(epsilon-caprolactone) as vehicles for the solubilization and controlled delivery of cyclosporine A.
Topics: Cyclosporine; Glycerol; Micelles; Pharmaceutical Vehicles; Polyesters; Solubility | 2005 |
Comparative in vitro properties and clinical pharmacokinetics of Paclitaxel following the administration of taxol(r) and paxene(r).
Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Excipients; Female; Glycerol; Humans; In Vitro Techniques; Male; Mathematics; Micelles; Middle Aged; Paclitaxel; Solvents; Surface Tension; Surface-Active Agents; Water | 2005 |
Cremophor EL, a non-ionic surfactant, promotes Ca(2+)-dependent process of cell death in rat thymocytes.
Topics: Animals; Calcimycin; Calcium; Cell Death; DNA; Drug Synergism; Enzyme Inhibitors; Flow Cytometry; Glycerol; Hydrogen Peroxide; Ionophores; Male; Rats; Rats, Wistar; Surface-Active Agents; Thymus Gland | 2005 |
Polysorbate 80 and Cremophor EL micelles deaggregate and solubilize nystatin at the core-corona interface.
Topics: Antifungal Agents; Glycerol; Micelles; Nystatin; Polysorbates; Solubility; Surface-Active Agents; Water | 2005 |
Paclitaxel-loaded PLGA nanoparticles: potentiation of anticancer activity by surface conjugation with wheat germ agglutinin.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chemistry, Pharmaceutical; Drug Synergism; Ethanol; Excipients; Flow Cytometry; Glycerol; Humans; Lung Neoplasms; Mice; Mice, SCID; Nanostructures; Neoplasm Transplantation; Paclitaxel; Solvents; Surface Properties; Wheat Germ Agglutinins | 2005 |
In vivo pharmacokinetic and tissue distribution studies in mice of alternative formulations for local and systemic delivery of Paclitaxel: gel, film, prodrug, liposomes and micelles.
Topics: Animals; Antineoplastic Agents, Phytogenic; Area Under Curve; Carbon Radioisotopes; Chitosan; Gels; Glycerol; Half-Life; Injections, Intravenous; Injections, Subcutaneous; Liposomes; Male; Mice; Micelles; Motion Pictures; Paclitaxel; Prodrugs; Tissue Distribution | 2005 |
In vitro and in vivo studies on vitamin E TPGS-emulsified poly(D,L-lactic-co-glycolic acid) nanoparticles for paclitaxel formulation.
Topics: Antineoplastic Agents, Phytogenic; Area Under Curve; Drug Carriers; Drug Delivery Systems; Emulsifying Agents; Glycerol; Humans; Lactic Acid; Nanostructures; Paclitaxel; Polyethylene Glycols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Surface-Active Agents; Vitamin E | 2006 |
The removal of Cremophor EL from paclitaxel for quantitative analysis by HPLC-UV.
Topics: Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Glycerol; Magnetic Resonance Spectroscopy; Mercuric Chloride; Paclitaxel; Spectrophotometry, Infrared; Spectroscopy, Fourier Transform Infrared; Surface-Active Agents; Technology, Pharmaceutical; Time Factors; Ultraviolet Rays | 2006 |
Hydrophobically modified glycol chitosan nanoparticles as carriers for paclitaxel.
Topics: Animals; Antineoplastic Agents, Phytogenic; Body Weight; Cell Line, Tumor; Cell Survival; Chitosan; Drug Carriers; Glycerol; Humans; Hydrophobic and Hydrophilic Interactions; Injections, Intravenous; Male; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Nanostructures; Paclitaxel; Technology, Pharmaceutical; Time Factors; Treatment Outcome | 2006 |
[Preparation and evaluation of self-microemulsifying drug delivery systems containing atorvastatin].
Topics: Administration, Oral; Animals; Area Under Curve; Atorvastatin; Biological Availability; Dogs; Drug Delivery Systems; Emulsions; Glycerol; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Particle Size; Polyethylene Glycols; Pyrroles; Solubility | 2005 |
Oxidative stress induced by Cremophor EL is not accompanied by changes in NF-kappaB activation or iNOS expression.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Glutathione; Glutathione Disulfide; Glycerol; Liver; Male; NF-kappa B; Nitric Oxide Synthase Type II; Oxidative Stress; Pharmaceutical Vehicles; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances | 2006 |
[Effect of self-microemulsifying system on cell tight junctions].
Topics: Actins; Caco-2 Cells; Cell Membrane; Cell Survival; Drug Delivery Systems; Electric Impedance; Emulsions; Ethylene Glycols; Glycerides; Glycerol; Humans; Mannitol; Membrane Proteins; Organic Chemicals; Phosphoproteins; Protein Transport; Tight Junctions; Zonula Occludens-1 Protein | 2006 |
Albumin-bound Paclitaxel: in metastatic breast cancer.
Topics: Albumins; Antineoplastic Agents; Breast Neoplasms; Clinical Trials as Topic; Female; Glycerol; Humans; Nanostructures; Neoplasm Metastasis; Neutropenia; Paclitaxel; Treatment Outcome | 2006 |
Albumin-bound Paclitaxel in metastatic breast cancer: viewpoints.
Topics: Albumins; Antineoplastic Agents; Breast Neoplasms; Clinical Trials as Topic; Female; Glycerol; Humans; Nanostructures; Neoplasm Metastasis; Neutropenia; Paclitaxel; Treatment Outcome | 2006 |
Determination of paclitaxel in human plasma following the administration of Genaxol or Genetaxyl by liquid chromatography/tandem mass spectrometry.
Topics: Administration, Oral; Antineoplastic Agents, Phytogenic; Chromatography, High Pressure Liquid; Female; Glycerol; Humans; Injections, Intravenous; Paclitaxel; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2006 |
Permeability assessment of poorly water-soluble compounds under solubilizing conditions: the reciprocal permeability approach.
Topics: Animals; Antipyrine; Cinnarizine; Diazepam; Glycerol; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Jejunum; Male; Micelles; Naproxen; Permeability; Polysorbates; Propranolol; Rats; Rats, Sprague-Dawley; Solubility; Water | 2006 |
Erythropoietin protects sensory axons against paclitaxel-induced distal degeneration.
Topics: Animals; Antineoplastic Agents, Phytogenic; Axons; Cells, Cultured; Dose-Response Relationship, Drug; Drug Carriers; Erythropoietin; Female; Ganglia, Spinal; Glycerol; Humans; Injections, Intraperitoneal; Mice; Nerve Degeneration; Neurons, Afferent; Neuroprotective Agents; Paclitaxel; Recombinant Proteins; Tubulin; Tyrosine | 2006 |
Impact of cremophor-EL and polysorbate-80 on digoxin permeability across rat jejunum: delineation of thermodynamic and transporter related events using the reciprocal permeability approach.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Digoxin; Glycerol; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Jejunum; Male; Permeability; Polysorbates; Rats; Rats, Sprague-Dawley; Serous Membrane; Surface-Active Agents; Thermodynamics; Vanadates; Verapamil | 2007 |
Drug transformation: Advances in drug delivery systems.
Topics: Anesthetics, Intravenous; Anesthetics, Local; Animals; Biotransformation; Chemistry, Pharmaceutical; Drug Delivery Systems; Excipients; Glycerol; Humans; Lidocaine; Liposomes; Nanoparticles; Pharmaceutical Preparations; Propofol; Rats | 2006 |
Reduction of ciclosporin and tacrolimus nephrotoxicity by plant polyphenols.
Topics: Aldehydes; Animals; Camellia sinensis; Chromatography, High Pressure Liquid; Cyclosporine; Flavonoids; Free Radicals; Glomerular Filtration Rate; Glycerol; Immunohistochemistry; Immunosuppressive Agents; Kidney; Kidney Diseases; Male; Olive Oil; Phenols; Phytotherapy; Plant Oils; Polyphenols; Rats; Rats, Sprague-Dawley; Tacrolimus | 2006 |
Increasing the proportional content of surfactant (Cremophor EL) relative to lipid in self-emulsifying lipid-based formulations of danazol reduces oral bioavailability in beagle dogs.
Topics: Administration, Oral; Animals; Biological Availability; Chemistry, Pharmaceutical; Cross-Over Studies; Danazol; Dogs; Drug Carriers; Drug Compounding; Emulsions; Estrogen Antagonists; Ethanol; Glycerides; Glycerol; Intestinal Absorption; Lipase; Lipids; Lipolysis; Male; Particle Size; Reproducibility of Results; Solubility; Solvents; Soybean Oil; Surface-Active Agents; Water | 2007 |
Novel biocompatible intraperitoneal drug delivery system increases tolerability and therapeutic efficacy of paclitaxel in a human ovarian cancer xenograft model.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Biocompatible Materials; Chitosan; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Carriers; Drug Implants; Eggs; Female; Glycerol; Humans; Injections, Intraperitoneal; Mice; Mice, Nude; Ovarian Neoplasms; Paclitaxel; Phosphatidylcholines; Xenograft Model Antitumor Assays | 2007 |
Ionically fixed polymeric nanoparticles as a novel drug carrier.
Topics: Animals; Antineoplastic Agents, Phytogenic; Area Under Curve; Calcium Chloride; Drug Carriers; Drug Stability; Glycerol; Injections, Intravenous; Lactic Acid; Molecular Weight; Nanoparticles; Paclitaxel; Particle Size; Polyesters; Polyethylene Glycols; Polymers; Rats; Rats, Sprague-Dawley; Spectrophotometry; Static Electricity | 2007 |
Controlled release of methotrexate from w/o microemulsion and its in vitro antitumor activity.
Topics: 2-Propanol; Antimetabolites, Antineoplastic; Breast Neoplasms; Caco-2 Cells; Cell Proliferation; Cell Survival; Chemistry, Pharmaceutical; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Carriers; Drug Compounding; Drug Stability; Emulsions; Female; Glycerol; Hexoses; Humans; Inhibitory Concentration 50; Methotrexate; Sodium Hydroxide; Solubility; Soybean Oil; Surface-Active Agents | 2007 |
Encapsulation of paclitaxel in macromolecular nanoshells.
Topics: Cell Cycle; Cell Line, Tumor; Cytoskeleton; Drug Delivery Systems; Glycerol; Humans; Macromolecular Substances; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Nanoparticles; Neoplasms; Paclitaxel; Polymers; Solvents | 2007 |
HPLC method for the determination of carboplatin and paclitaxel with cremophorEL in an amphiphilic polymer matrix.
Topics: Antineoplastic Agents; Calibration; Carboplatin; Chromatography, High Pressure Liquid; Glycerol; Paclitaxel; Polyethylene Glycols; Polyglactin 910; Solvents; Surface-Active Agents | 2007 |
[Preparation and quality evaluation of quercetin self-emulsifyied drug delivery systems].
Topics: Antioxidants; Butanols; Chromatography, High Pressure Liquid; Drug Delivery Systems; Drug Stability; Emulsions; Glycerol; Oleic Acids; Particle Size; Quercetin; Solubility; Solvents; Technology, Pharmaceutical | 2007 |
Application of mixture experimental design to simvastatin apparent solubility predictions in the microemulsifion formed by self-microemulsifying.
Topics: Administration, Oral; Biological Availability; Chemical Precipitation; Chemistry, Pharmaceutical; Dosage Forms; Emulsions; Gastric Juice; Glycerol; Hypolipidemic Agents; Laurates; Models, Theoretical; Propylene Glycols; Simvastatin; Solubility; Surface-Active Agents; Triglycerides | 2007 |
Dry adsorbed emulsion of simvastatin: optimization and in vivo advantage.
Topics: Acrylates; Adsorption; Animals; Anticholesteremic Agents; Biological Availability; Calorimetry, Differential Scanning; Cholesterol; Emulsions; Female; Glycerol; Hyperlipidemias; Lipoproteins, HDL; Microscopy, Electron, Scanning; Particle Size; Polysorbates; Powders; Rats; Rats, Sprague-Dawley; Rheology; Silicon Dioxide; Simvastatin; Solubility; Soybean Oil; Viscosity; X-Ray Diffraction | 2007 |
Quantitative determination of anti-tumor agent bis(4-fluorobenzyl)trisulfide, fluorapacin and its pharmaceutical preparation by high-performance liquid chromatography.
Topics: alpha-Tocopherol; Antineoplastic Agents; Calibration; Chromatography, High Pressure Liquid; Drug Stability; Ethanol; Fluorobenzenes; Glycerol; Molecular Structure; Pharmaceutical Preparations; Quality Control; Reproducibility of Results; Sulfides; Technology, Pharmaceutical | 2008 |
Solubilization and preformulation of poorly water soluble and hydrolysis susceptible N-epoxymethyl-1,8-naphthalimide (ENA) compound.
Topics: Antineoplastic Agents; Chemical Precipitation; Drug Stability; Drug Storage; Ethanol; Excipients; Glycerol; Hydrolysis; Micelles; Naphthalimides; Solubility; Surface-Active Agents; Temperature | 2008 |
Enhanced oral bioavailability of paclitaxel by D-alpha-tocopheryl polyethylene glycol 400 succinate in mice.
Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Biological Availability; Caco-2 Cells; Ethanol; Glycerol; Humans; Injections, Intravenous; Male; Mice; Mice, Inbred BALB C; Microsomes, Liver; Paclitaxel; Permeability; Polyethylene Glycols; Rhodamine 123; Solvents; Steroid Hydroxylases; Vitamin E | 2008 |
Formulation design of microemulsion for dermal delivery of penciclovir.
Topics: Acyclovir; Algorithms; Animals; Antiviral Agents; Chemistry, Pharmaceutical; Diffusion Chambers, Culture; Drug Design; Emulsions; Ethanol; Glycerol; Guanine; Male; Mice; Oils; Skin Absorption; Surface-Active Agents; Water | 2008 |
[Design and in vitro evaluation of self-microemulsifying drug delivery systems for piroxicam].
Topics: Administration, Oral; Drug Compounding; Drug Delivery Systems; Emulsions; Glycerides; Glycerol; Particle Size; Piroxicam; Polyethylene Glycols; Propanols; Solubility; Solvents; Surface-Active Agents | 2008 |
A cremophor-free formulation for tanespimycin (17-AAG) using PEO-b-PDLLA micelles: characterization and pharmacokinetics in rats.
Topics: Animals; Benzoquinones; Cell Line, Tumor; Cell Survival; Dioxanes; Drug Carriers; Glycerol; Humans; Lactams, Macrocyclic; Male; Micelles; Nanoparticles; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Solubility; Tissue Distribution | 2009 |
Human whole blood assay for rapid and routine testing of non-steroidal anti-inflammatory drugs (NSAIDs) on cyclo-oxygenase-2 activity.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Biological Assay; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Ethanol; Glycerol; Humans; Hydrophobic and Hydrophilic Interactions; Inhibitory Concentration 50; Lipopolysaccharides; Pharmaceutical Vehicles; Reproducibility of Results; Solubility | 2008 |
Effect of unpurified Cremophor EL on the solution stability of paclitaxel.
Topics: Antineoplastic Agents, Phytogenic; Bromphenol Blue; Carboxylic Acids; Colorimetry; Drug Contamination; Drug Stability; Glycerol; Hydrogen-Ion Concentration; Indicators and Reagents; Injections; Molecular Structure; Paclitaxel; Pharmacopoeias as Topic; Solutions; Spectroscopy, Fourier Transform Infrared | 2009 |
Paclitaxel-loaded PEGylated PLGA-based nanoparticles: in vitro and in vivo evaluation.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Survival; Drug Carriers; Drug Evaluation, Preclinical; Ethylene Oxide; Excipients; Flow Cytometry; Glycerol; HeLa Cells; Humans; Lactic Acid; Lactones; Male; Mice; Mice, Inbred Strains; Nanoparticles; Neoplasms; Paclitaxel; Particle Size; Polyethylene Glycols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Surface-Active Agents; Survival Analysis | 2009 |
Enhanced stability of ramipril in nanoemulsion containing cremophor-EL: a technical note.
Topics: Angiotensin-Converting Enzyme Inhibitors; Drug Stability; Emulsions; Glycerol; Hydrogen-Ion Concentration; Nanotechnology; Ramipril | 2008 |
Comparison of PEG chain length and density on amphiphilic macromolecular nanocarriers: self-assembled and unimolecular micelles.
Topics: Delayed-Action Preparations; Drug Carriers; Drug Delivery Systems; Glycerol; Macromolecular Substances; Micelles; Models, Chemical; Molecular Structure; Molecular Weight; Polyethylene Glycols; Solubility; Temperature; Water | 2009 |
A novel camptothecin derivative incorporated in nano-carrier induced distinguished improvement in solubility, stability and anti-tumor activity both in vitro and in vivo.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Drug Carriers; Drug Compounding; Drug Stability; Emulsifying Agents; Emulsions; Fluorescent Dyes; Glycerol; Hemolysis; Humans; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Male; Mice; Microscopy, Fluorescence; Nanostructures; Neoplasms; Oxazines; Particle Size; Rabbits; Solubility; Xenograft Model Antitumor Assays | 2009 |
Formulation development and bioavailability evaluation of a self-nanoemulsified drug delivery system of oleanolic acid.
Topics: Administration, Oral; Animals; Biological Availability; Chemistry, Pharmaceutical; Dosage Forms; Drug Carriers; Drug Compounding; Drug Stability; Emulsions; Ethylene Glycols; Glycerides; Glycerol; Male; Microscopy, Electron, Transmission; Nanoparticles; Oils; Oleanolic Acid; Organic Chemicals; Plant Preparations; Rats; Rats, Sprague-Dawley; Solubility; Surface Properties; Surface-Active Agents; Tablets; Technology, Pharmaceutical | 2009 |
Multi-drug loaded polymeric micelles for simultaneous delivery of poorly soluble anticancer drugs.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Drug Carriers; Drug Delivery Systems; Drug Design; Glycerol; Half-Life; Light; Magnetic Resonance Spectroscopy; Micelles; Nephelometry and Turbidimetry; Polymers; Rats; Scattering, Radiation; Solubility | 2009 |
Surfactants influence the distribution of taxanes in peritoneal dissemination tumor-bearing rats.
Topics: Animals; Antineoplastic Agents, Phytogenic; Area Under Curve; Ascites; Biological Transport; Carcinoma, Hepatocellular; Cell Line, Tumor; Docetaxel; Female; Glycerol; Injections, Intraperitoneal; Liver Neoplasms; Paclitaxel; Peritoneal Neoplasms; Polysorbates; Rats; Surface-Active Agents; Taxoids; Tissue Distribution | 2010 |
Delayed seizure associated with paclitaxel-Cremophor el in a patient with early-stage breast cancer.
Topics: Adult; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Female; Glycerol; Humans; Paclitaxel; Pharmaceutical Vehicles; Seizures; Time Factors | 2009 |
Docetaxel microemulsion for enhanced oral bioavailability: preparation and in vitro and in vivo evaluation.
Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Biological Availability; Caco-2 Cells; Chemistry, Pharmaceutical; Docetaxel; Drug Carriers; Drug Compounding; Emulsions; Ethylene Glycols; Glycerol; Humans; Intestinal Absorption; Intestinal Mucosa; Male; Oils; Particle Size; Permeability; Rats; Rats, Sprague-Dawley; Solubility; Surface-Active Agents; Taxoids | 2009 |
Folate-mediated solid-liquid lipid nanoparticles for paclitaxel-coated poly(ethylene glycol).
Topics: Animals; Antineoplastic Agents, Phytogenic; Folic Acid; Glycerol; Male; Mice; Nanoparticles; Paclitaxel; Polyethylene Glycols; Polymers; Rats; Rats, Sprague-Dawley; Sarcoma 180; Serum Albumin; Solubility | 2010 |
Differential pharmacodynamic effects of paclitaxel formulations in an intracranial rat brain tumor model.
Topics: Animals; Antineoplastic Agents, Phytogenic; Body Weight; Brain Neoplasms; Chemistry, Pharmaceutical; Disease Models, Animal; Drug Screening Assays, Antitumor; Glycerol; Liposomes; Male; Maximum Tolerated Dose; Models, Theoretical; Neutropenia; Paclitaxel; Pharmaceutical Vehicles; Rats; Rats, Inbred Strains; Tumor Burden | 2010 |
Application of Box-Behnken design in understanding the quality of genistein self-nanoemulsified drug delivery systems and optimizing its formulation.
Topics: Algorithms; Biological Availability; Capsules; Chemistry, Pharmaceutical; Drug Delivery Systems; Emulsions; Ethylene Glycols; Gelatin; Genistein; Glycerides; Glycerol; Models, Statistical; Nanostructures; Nanotechnology; Nephelometry and Turbidimetry; Oils; Organic Chemicals; Particle Size; Phase Transition; Regression Analysis; Solubility; Surface-Active Agents; Technology, Pharmaceutical; Triglycerides | 2009 |
Pharmacokinetics of PSC 833 (valspodar) in its Cremophor EL formulation in rat.
Topics: Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporins; Glycerol; Injections, Intravenous; Liver; Male; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2010 |
Preparation of lorazepam-loaded microemulsions for intranasal delivery and its pharmacokinetics.
Topics: Administration, Intranasal; Animals; Area Under Curve; Dose-Response Relationship, Drug; Emulsions; Ethylene Glycols; Glycerol; Hypnotics and Sedatives; Injections, Intramuscular; Lorazepam; Particle Size; Pharmaceutical Vehicles; Rabbits; Solubility; Surface-Active Agents | 2009 |
Preparation and evaluation of self-nanoemulsified drug delivery systems (SNEDDSs) of matrine based on drug-phospholipid complex technique.
Topics: Administration, Oral; Alkaloids; Animals; Biological Availability; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Drug Carriers; Emulsions; Ethylene Glycols; Glycerol; Hydrogen-Ion Concentration; Injections, Intravenous; Male; Matrines; Nanostructures; Nanotechnology; Particle Size; Phospholipids; Quinolizines; Rats; Rats, Wistar; Solubility; Spectrophotometry, Infrared; Surface-Active Agents; Technology, Pharmaceutical | 2010 |
Development of a polymeric micellar formulation for valspodar and assessment of its pharmacokinetics in rat.
Topics: Administration, Oral; Animals; Area Under Curve; Cyclosporins; Drug Carriers; Ethanol; Excipients; Glycerol; Injections, Intravenous; Male; Micelles; Polyesters; Polymers; Protein Binding; Rats; Rats, Sprague-Dawley; Solubility; Time Factors; Tissue Distribution | 2010 |
Synthesis and characterization of low-toxic amphiphilic chitosan derivatives and their application as micelle carrier for antitumor drug.
Topics: Animals; Antineoplastic Agents, Phytogenic; Chitosan; Dialysis; Dose-Response Relationship, Drug; Drug Carriers; Drug Delivery Systems; Drug Stability; Female; Glycerol; Guinea Pigs; Magnetic Resonance Spectroscopy; Male; Maximum Tolerated Dose; Mice; Micelles; Paclitaxel; Solubility; Spectroscopy, Fourier Transform Infrared; Toxicity Tests, Acute | 2010 |
Targeted cancer therapy with novel high drug-loading nanocrystals.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Carrier Proteins; Chemistry, Pharmaceutical; Drug Delivery Systems; Excipients; Female; Folate Receptors, GPI-Anchored; Glycerol; Hemolysis; Humans; Lung Neoplasms; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy, Electron, Transmission; Nanoparticles; Neoplasm Transplantation; Neoplasms; Paclitaxel; Poloxamer; Receptors, Cell Surface; Surface-Active Agents | 2010 |
[Cremophor EL test for identification of Malassezia species].
Topics: Culture Media; Glycerol; Malassezia | 2010 |
Influence of Cremophor EL and genetic polymorphisms on the pharmacokinetics of paclitaxel and its metabolites using a mechanism-based model.
Topics: Analysis of Variance; Antineoplastic Agents, Phytogenic; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biotransformation; Chemistry, Pharmaceutical; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP3A; Drug Carriers; Female; Genital Neoplasms, Female; Glycerol; Humans; Middle Aged; Models, Biological; Paclitaxel; Polymorphism, Single Nucleotide | 2011 |
The uptake of paclitaxel and docetaxel into ex vivo porcine bladder tissue from polymeric micelle formulations.
Topics: Administration, Intravesical; Animals; Antineoplastic Agents; Biological Transport; Docetaxel; Drug Carriers; Drug Compounding; Glycerol; In Vitro Techniques; Male; Micelles; Nanoparticles; Paclitaxel; Pharmaceutical Vehicles; Polyesters; Polyethylene Glycols; Polysorbates; Swine; Taxoids; Tissue Distribution; Urinary Bladder; Urinary Bladder Neoplasms | 2011 |
Physiological and molecular characterization of atypical lipid-dependent Malassezia yeasts from a dog with skin lesions: adaptation to a new host?
Topics: Adaptation, Biological; Amino Acid Sequence; Animals; Cell Nucleus; Chitin Synthase; Dermatomycoses; DNA, Fungal; DNA, Ribosomal Spacer; Dog Diseases; Dogs; Female; Genes, Fungal; Glycerol; Malassezia; Molecular Sequence Data; Phylogeny | 2011 |
Modulation of voltage-gated ion channels on SH-SY5Y neuroblastoma by non-ionic surfactant, Cremophor EL.
Topics: Action Potentials; Cell Line, Tumor; Glycerol; Humans; Neuroblastoma; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Sodium Channels; Surface-Active Agents | 2010 |
Controlled release of oral tetrahydrocurcumin from a novel self-emulsifying floating drug delivery system (SEFDDS).
Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Curcumin; Delayed-Action Preparations; Drug Delivery Systems; Drug Stability; Emulsifying Agents; Emulsions; Glycerol; Humans; Solubility | 2011 |
An oil-free microemulsion for intravenous delivery of diallyl trisulfide: formulation and evaluation.
Topics: Allyl Compounds; Anaphylaxis; Animals; Antioxidants; Area Under Curve; Emulsions; Ethanol; Excipients; Female; Glycerol; Guinea Pigs; Injections, Intravenous; Lethal Dose 50; Male; Mice; Particle Size; Propylene Glycol; Rabbits; Rats; Rats, Sprague-Dawley; Sodium Chloride; Sulfides; Time Factors; Tissue Distribution | 2011 |
A novel paclitaxel microemulsion containing a reduced amount of Cremophor EL: pharmacokinetics, biodistribution, and in vivo antitumor efficacy and safety.
Topics: Animals; Antineoplastic Agents; Dogs; Emulsions; Female; Glycerol; Humans; Male; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Paclitaxel; Particle Size; Pharmaceutical Vehicles; Rabbits; Rats; Rats, Sprague-Dawley; Tissue Distribution; Xenograft Model Antitumor Assays | 2011 |
Cyclosporine A-induced acute hepatotoxicity in guinea pigs is associated with endothelin-mediated decrease in local hepatic blood flow.
Topics: Animals; Bosentan; Cyclosporine; Dose-Response Relationship, Drug; Endothelins; Female; Glycerol; Guinea Pigs; Liver; Liver Circulation; Male; Peptides, Cyclic; Sulfonamides | 2011 |
Preparation and evaluation of Cremophor-free paclitaxel solid dispersion by a supercritical antisolvent process.
Topics: Animals; Chemistry, Pharmaceutical; Drug Stability; Glycerol; Injections, Intravenous; Male; Nanotechnology; Paclitaxel; Rats; Rats, Sprague-Dawley; Solubility; Tissue Distribution | 2011 |
Localized delivery of paclitaxel using elastic liposomes: formulation development and evaluation.
Topics: Animals; Antineoplastic Agents, Phytogenic; Delayed-Action Preparations; Elasticity; Glycerol; Hemolysis; Liposomes; Male; Paclitaxel; Rabbits; Rats; Skin Absorption; Spectroscopy, Fourier Transform Infrared; Toxicity Tests | 2011 |
Absorption of the novel artemisinin derivatives artemisone and artemiside: potential application of Pheroid™ technology.
Topics: Absorption; Administration, Oral; alpha-Tocopherol; Animals; Antimalarials; Arachidonic Acid; Artemisinins; Colloids; Drug Carriers; Drug Compounding; Drug Delivery Systems; Excipients; Glycerol; Malaria, Cerebral; Male; Mice; Mice, Inbred C57BL; Particle Size; Plasmodium; Vitamins | 2011 |
Formulation, characterization, and clinical evaluation of microemulsion containing clotrimazole for topical delivery.
Topics: Administration, Topical; Adolescent; Adult; Animals; Antifungal Agents; Benzyl Alcohol; Clotrimazole; Dermatomycoses; Drug Compounding; Drug Evaluation, Preclinical; Drug Stability; Emulsions; Female; Glycerol; Humans; Male; Mice; Middle Aged; Myristates; Oils; Oleic Acid; Particle Size; Plant Oils; Polysorbates; Skin Absorption; Solubility; Surface-Active Agents | 2011 |
Formulation development and optimization of a novel Cremophore EL-based nanoemulsion using ultrasound cavitation.
Topics: Aspirin; Chemistry, Pharmaceutical; Drug Stability; Emulsions; Glycerol; Hydrogen-Ion Concentration; Microscopy, Electron, Scanning; Models, Theoretical; Nanostructures; Oils; Sonication; Surface-Active Agents; Water | 2012 |
A comparative evaluation of mono-, di- and triglyceride of medium chain fatty acids by lipid/surfactant/water phase diagram, solubility determination and dispersion testing for application in pharmaceutical dosage form development.
Topics: Chemistry, Pharmaceutical; Danazol; Diglycerides; Dosage Forms; Drug Delivery Systems; Emulsions; Fatty Acids; Glycerides; Glycerol; Monoglycerides; Particle Size; Solubility; Surface-Active Agents; Triglycerides; Water | 2012 |
Design of fenofibrate microemulsion for improved bioavailability.
Topics: Administration, Oral; Animals; Biological Availability; Capsules; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Dogs; Drug Compounding; Drug Stability; Emulsions; Ethylene Glycols; Fenofibrate; Glycerides; Glycerol; Hypolipidemic Agents; Male; Microscopy, Electron, Transmission; Polyethylene Glycols; Solubility; Surface-Active Agents | 2011 |
Dual targeting folate-conjugated hyaluronic acid polymeric micelles for paclitaxel delivery.
Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Survival; Drug Carriers; Endocytosis; Folate Receptors, GPI-Anchored; Folic Acid; Glycerol; Humans; Hyaluronan Receptors; Hyaluronic Acid; MCF-7 Cells; Micelles; Nanostructures; Paclitaxel; Polymers | 2011 |
Investigation of microemulsion microstructures and their relationship to transdermal permeation of model drugs: ketoprofen, lidocaine, and caffeine.
Topics: Administration, Cutaneous; Animals; Azepines; Caffeine; Calorimetry, Differential Scanning; Electric Conductivity; Emulsions; Glycerides; Glycerol; Hydrophobic and Hydrophilic Interactions; In Vitro Techniques; Ketoprofen; Lidocaine; Myristates; Organic Chemicals; Permeability; Skin; Sulfur Compounds; Surface-Active Agents; Swine; Water | 2011 |
Estimation of P-glycoprotein-mediated efflux in the oral absorption of P-gp substrate drugs from simultaneous analysis of drug dissolution and permeation.
Topics: Algorithms; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Drug Interactions; Erythromycin; Gene Expression; Glycerol; Humans; Intestinal Absorption; Loperamide; Models, Biological; Pharmaceutical Preparations; Propanolamines; Puromycin; Quinidine; Saquinavir; Solubility; Surface-Active Agents; Terfenadine; Verapamil; Vinblastine | 2011 |
Complement activation by polyethoxylated pharmaceutical surfactants: Cremophor-EL, Tween-80 and Tween-20.
Topics: Antineoplastic Agents; Complement Activation; Docetaxel; Glycerol; Humans; Paclitaxel; Polysorbates; Surface-Active Agents; Taxoids | 2012 |
Nanohybrid systems of non-ionic surfactant inserting liposomes loading paclitaxel for reversal of multidrug resistance.
Topics: Adenosine Triphosphate; Antineoplastic Agents, Phytogenic; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Cycle; Cell Line, Tumor; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Drug Compounding; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Glycerol; Humans; Lipids; Liposomes; Lung Neoplasms; Nanotechnology; Paclitaxel; Particle Size; Poloxamer; Polyethylene Glycols; Rhodamine 123; Solubility; Stearic Acids; Surface-Active Agents; Technology, Pharmaceutical; Time Factors | 2012 |
Development of optimized self-nano-emulsifying drug delivery systems (SNEDDS) of carvedilol with enhanced bioavailability potential.
Topics: Animals; Biological Availability; Caprylates; Carbazoles; Cardiovascular Agents; Carvedilol; Chemistry, Pharmaceutical; Drug Delivery Systems; Drug Stability; Emulsions; Ethylene Glycols; Excipients; Glycerides; Glycerol; Intestinal Absorption; Jejunum; Male; Microscopy, Electron, Transmission; Nanostructures; Oils; Particle Size; Perfusion; Propanolamines; Rats; Rats, Wistar; Solubility | 2011 |
Evaluation of biosafety and intracellular uptake of Cremophor EL free paclitaxel elastic liposomal formulation.
Topics: Animals; Cell Line, Tumor; Chemistry, Pharmaceutical; Drug Evaluation, Preclinical; Elasticity; Female; Glycerol; Humans; Intracellular Fluid; Liposomes; Male; Mice; Paclitaxel; Pharmaceutical Vehicles; Random Allocation; Toxicity Tests, Acute | 2012 |
Paclitaxel in tyrosine-derived nanospheres as a potential anti-cancer agent: in vivo evaluation of toxicity and efficacy in comparison with paclitaxel in Cremophor.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Drug Carriers; Female; Glycerol; Humans; Maximum Tolerated Dose; Mice; Mice, Nude; Nanospheres; Neoplasms; Paclitaxel; Pharmaceutical Vehicles; Tyrosine; Xenograft Model Antitumor Assays | 2012 |
Enhanced dissolution, stability and physicochemical characterization of ATRA/2-hydroxypropyl-β-cyclodextrin inclusion complex pellets prepared by fluid-bed coating technique.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Antineoplastic Agents; beta-Cyclodextrins; Calorimetry, Differential Scanning; Chemical Precipitation; Crystallization; Dosage Forms; Drug Compounding; Drug Stability; Drug Storage; Excipients; Feasibility Studies; Glycerol; Humidity; Magnetic Resonance Spectroscopy; Photolysis; Povidone; Solubility; Spectroscopy, Fourier Transform Infrared; Tretinoin; X-Ray Diffraction | 2013 |
Molecular modelling and multisimplex optimization of tocotrienol-rich self emulsified drug delivery systems.
Topics: Chemistry, Pharmaceutical; Drug Carriers; Drug Compounding; Emulsions; Glycerol; Models, Molecular; Molecular Structure; Palm Oil; Particle Size; Plant Oils; Polysorbates; Surface-Active Agents; Technology, Pharmaceutical; Tocotrienols; Vitamins | 2012 |
Assessment of the percutaneous penetration of indomethacin from soybean oil microemulsion: effects of the HLB value of mixed surfactants.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Emulsions; Excipients; Glycerol; Hexoses; In Vitro Techniques; Indomethacin; Mice; Skin Absorption; Soybean Oil; Surface-Active Agents | 2012 |
Efficacy and toxicological studies of cremophor EL free alternative paclitaxel formulation.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Small Cell; Cell Line, Tumor; Deoxycholic Acid; Dose-Response Relationship, Drug; Excipients; Female; Glycerol; Glycine max; Humans; Lethal Dose 50; Liposomes; Lung Neoplasms; Male; Maximum Tolerated Dose; Mice; Paclitaxel; Phosphatidylcholines | 2011 |
Antitumor effect and pharmacokinetics of intraperitoneal NK105, a nanomicellar paclitaxel formulation for peritoneal dissemination.
Topics: Animals; Antineoplastic Agents, Phytogenic; Area Under Curve; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Ethanol; Female; Glycerol; Humans; Injections, Intraperitoneal; Mice; Mice, Inbred BALB C; Mice, Nude; Micelles; Nanoparticles; Paclitaxel; Rabbits; Stomach Neoplasms; Tissue Distribution; Xenograft Model Antitumor Assays | 2012 |
The studies of phase equilibria and efficiency assessment for self-emulsifying lipid-based formulations.
Topics: Chemistry, Pharmaceutical; Emulsions; Excipients; Glycerol; Hydrophobic and Hydrophilic Interactions; Lipids; Oleic Acid; Particle Size; Phase Transition; Solubility; Solvents; Surface-Active Agents; Technology, Pharmaceutical; Triglycerides; Water | 2012 |
Pharmacokinetics, tissue distribution and anti-tumour efficacy of paclitaxel delivered by polyvinylpyrrolidone solid dispersion.
Topics: Animals; Antineoplastic Agents, Phytogenic; Area Under Curve; Cell Line, Tumor; Drug Carriers; Female; Glycerol; Humans; Lethal Dose 50; Male; Mice; Mice, Inbred ICR; Mice, Nude; Neoplasms; Paclitaxel; Phytotherapy; Plant Preparations; Povidone; Rats; Rats, Sprague-Dawley; Taxus; Tissue Distribution | 2012 |
Single non-ionic surfactant based self-nanoemulsifying drug delivery systems: formulation, characterization, cytotoxicity and permeability enhancement study.
Topics: Anticholesteremic Agents; Atorvastatin; Caco-2 Cells; Chemistry, Pharmaceutical; Drug Delivery Systems; Glycerol; Heptanoic Acids; Humans; Nanoparticles; Particle Size; Permeability; Pyrroles; Solubility; Surface-Active Agents | 2013 |
Effect of intratumoral injection on the biodistribution and therapeutic potential of novel chemophor EL-modified single-walled nanotube loading doxorubicin.
Topics: Absorption; Animals; Antibiotics, Antineoplastic; Cell Line, Tumor; Doxorubicin; Drug Compounding; Drug Delivery Systems; Female; Glycerol; Hydrophobic and Hydrophilic Interactions; Injections, Intralesional; Mice; Mice, Inbred ICR; Nanotubes, Carbon; Neoplasm Transplantation; Pharmaceutical Vehicles; Sarcoma 180; Solubility; Tissue Distribution; Tumor Burden | 2012 |
Pharmaceutical excipients influence the function of human uptake transporting proteins.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; beta-Cyclodextrins; Biological Transport; Cell Line; Estradiol; Estrone; Excipients; Glycerol; HEK293 Cells; Humans; Multidrug Resistance-Associated Protein 2; Organic Anion Transporters; Organic Anion Transporters, Sodium-Dependent; Polyethylene Glycols; Stearic Acids; Sulfobromophthalein; Symporters; Taurocholic Acid | 2012 |
Cellular and vascular effects of the photodynamic agent temocene are modulated by the delivery vehicle.
Topics: Animals; Cell Line, Tumor; Drug Carriers; Glycerol; Light; Liposomes; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Micelles; Neoplasms; Photochemotherapy; Photosensitizing Agents; Porphyrins; Tumor Burden | 2012 |
Application of Langmuir-Blodgett film technology on studying the formulation of self-microemulsifying drug delivery system (SMEDDS).
Topics: Chemistry, Pharmaceutical; Drug Delivery Systems; Emulsions; Glycerol; Methylene Chloride; Oleic Acid; Polyethylene Glycols; Triglycerides | 2012 |
Nanoemulsion liquid preconcentrates for raloxifene hydrochloride: optimization and in vivo appraisal.
Topics: Animals; Drug Carriers; Drug Stability; Emulsions; Excipients; Female; Glycerol; Hydrogen-Ion Concentration; Microscopy, Electron, Transmission; Nanoparticles; Particle Size; Photomicrography; Raloxifene Hydrochloride; Rats; Rats, Wistar; Solubility; Vaginal Smears | 2012 |
Stable synthetic bacteriochlorins for photodynamic therapy: role of dicyano peripheral groups, central metal substitution (2H, Zn, Pd), and Cremophor EL delivery.
Topics: Animals; Coordination Complexes; Glycerol; HeLa Cells; Humans; Neoplasms; Palladium; Pharmaceutical Vehicles; Photochemotherapy; Photosensitizing Agents; Porphyrins; Zinc | 2012 |
Intracellular distribution and mechanisms of actions of photosensitizer Zinc(II)-phthalocyanine solubilized in Cremophor EL against human hepatocellular carcinoma HepG2 cells.
Topics: Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Caspase 9; Cell Cycle Checkpoints; Cell Line, Tumor; Fibroblasts; Glycerol; Hep G2 Cells; Humans; Indoles; Liver Neoplasms; Lung; Organometallic Compounds; Photochemotherapy; Photosensitizing Agents; Reactive Oxygen Species; Stomach Neoplasms | 2013 |
Formulation optimization of a palm-based nanoemulsion system containing levodopa.
Topics: Chemistry, Pharmaceutical; Drug Stability; Emulsions; Glycerol; Levodopa; Models, Molecular; Nanostructures; Palm Oil; Particle Size; Plant Oils; Surface Properties | 2012 |
Kinetic analysis of the toxicity of pharmaceutical excipients Cremophor EL and RH40 on endothelial and epithelial cells.
Topics: Animals; Caco-2 Cells; Cell Death; Cell Line; Cell Survival; Cells, Cultured; Endothelial Cells; Epithelial Cells; Excipients; Glycerol; Humans; Kinetics; Polyethylene Glycols; Rats | 2013 |
Taxol(®)-induced phosphatidylserine exposure and microvesicle formation in red blood cells is mediated by its vehicle Cremophor(®) EL.
Topics: Cells, Cultured; Chemistry, Pharmaceutical; Erythrocytes; Flow Cytometry; Glycerol; Hemolysis; Human Umbilical Vein Endothelial Cells; Humans; Paclitaxel; Phosphatidylserines | 2013 |
Formulation and cytotoxicity evaluation of new self-emulsifying multiple W/O/W nanoemulsions.
Topics: Analysis of Variance; Apoptosis; Cell Line; Cell Survival; Drug Stability; Emulsions; Epithelial Cells; Epithelium, Corneal; Glycerides; Glycerol; Humans; Nanoparticles; Organic Chemicals; Pharmaceutical Vehicles; Polysorbates; Surface-Active Agents; Water | 2013 |
3,3',5,5'-Tetramethylbenzidine in hypochlorous acid and taurine chloramine scavenging assays: interference of dimethyl sulfoxide and other vehicles.
Topics: Benzidines; Dimethyl Sulfoxide; Ethanol; Glycerol; Hypochlorous Acid; Oxidation-Reduction; Quercetin; Taurine | 2013 |
Identification, solubility enhancement and in vivo testing of a cyanide antidote candidate.
Topics: Animals; Antidotes; Cyanides; Ethanol; Glycerol; Male; Mice; Polyethylene Glycols; Solubility; Solvents; Sulfides; Surface-Active Agents | 2013 |
Compare and contrast the effects of surfactants (PluronicF-127 and CremophorEL) and sugars (β-cyclodextrin and inulin) on properties of spray dried and crystallised lysozyme.
Topics: Acetylglucosamine; beta-Cyclodextrins; Chemistry, Pharmaceutical; Crystallization; Desiccation; Drug Stability; Glycerol; Inulin; Micrococcus; Muramic Acids; Muramidase; Poloxamer; Surface-Active Agents | 2013 |
Self-microemulsifying drug delivery system for improved oral bioavailability of oleanolic acid: design and evaluation.
Topics: Administration, Oral; Analysis of Variance; Animals; Biological Availability; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Drug Delivery Systems; Emulsions; Ethanol; Glycerol; Male; Mass Spectrometry; Nanoparticles; Oleanolic Acid; Oleic Acids; Rats; Rats, Sprague-Dawley; Solubility; Surface-Active Agents; Viscosity | 2013 |
Enhanced bioavailability of poorly absorbed hydrophilic compounds through drug complex/in situ gelling formulation.
Topics: Absorption; Animals; Biological Availability; Chemistry, Pharmaceutical; Drug Carriers; Female; Gels; Glycerol; Guanidines; Hydrophobic and Hydrophilic Interactions; Male; Rats; Rats, Sprague-Dawley; Sodium Dodecyl Sulfate; Sulfonamides | 2013 |
Solid self-emulsifying drug delivery system (S-SEDDS) for improved dissolution rate of fenofibrate.
Topics: Drug Delivery Systems; Emulsions; Fenofibrate; Glycerol; Hypolipidemic Agents; Solubility; Triglycerides | 2014 |
Enhanced topical delivery of finasteride using glyceryl monooleate-based liquid crystalline nanoparticles stabilized by cremophor surfactants.
Topics: Administration, Cutaneous; Animals; Drug Delivery Systems; Finasteride; Glycerides; Glycerol; Liquid Crystals; Nanoparticles; Particle Size; Permeability; Polyethylene Glycols; Skin; Skin Absorption; Surface-Active Agents; Swine | 2014 |
Microdissection and visualization of individual hair follicles for lineage tracing studies.
Topics: Animals; Cell Lineage; Clone Cells; Corn Oil; Genes, Reporter; Glycerol; Hair Follicle; Injections; Integrases; Luminescent Proteins; Mice; Microdissection; Microscopy, Confocal; Molecular Imaging; Staining and Labeling; Tamoxifen; Tissue Fixation | 2014 |
Anti-cancer, pharmacokinetic and biodistribution studies of cremophor el free alternative paclitaxel formulation.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Ehrlich Tumor; Chemistry, Pharmaceutical; Female; Glycerol; Male; Mice; Paclitaxel; Tissue Distribution | 2014 |
Preparation and delivery of 4-hydroxy-tamoxifen for clonal and polyclonal labeling of cells of the surface ectoderm, skin, and hair follicle.
Topics: Animals; Buffers; Clone Cells; Ectoderm; Ethanol; Glycerol; Hair Follicle; Injections; Integrases; Mice; Skin; Staining and Labeling; Tamoxifen | 2014 |
Formulation of solid self-nanoemulsifying drug delivery systems using N-methyl pyrrolidone as cosolvent.
Topics: Abattoirs; Animals; Atorvastatin; Drug Compounding; Drug Delivery Systems; Drug Liberation; Drug Stability; Emulsions; Glycerol; Goats; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Nanostructures; Particle Size; Pharmaceutical Vehicles; Phase Transition; Polysorbates; Pyrrolidinones | 2015 |
Self-emulsifying pellets: relations between kinetic parameters of drug release and emulsion reconstitution-influence of formulation variables.
Topics: Cellulose; Chemistry, Pharmaceutical; Drug Delivery Systems; Drug Implants; Drug Liberation; Emulsions; Excipients; Furosemide; Glycerol; Kinetics; Oils; Particle Size; Pharmaceutical Preparations; Propranolol; Solubility; Surface-Active Agents; Water | 2014 |
Systemic toxicity induced by paclitaxel in vivo is associated with the solvent cremophor EL through oxidative stress-driven mechanisms.
Topics: Animals; Antineoplastic Agents, Phytogenic; Catalase; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Erythrocyte Count; Erythrocytes; Glutathione; Glycerol; Hemoglobins; Lipid Peroxidation; Male; Malondialdehyde; Nitric Oxide; Oxidative Stress; Paclitaxel; Rats; Rats, Wistar; Superoxide Dismutase | 2014 |
In vivo evaluation of an oral self-microemulsifying drug delivery system (SMEDDS) for leuprorelin.
Topics: Administration, Oral; Animals; Antineoplastic Agents, Hormonal; Caprylates; Drug Delivery Systems; Emulsions; Fertility Agents, Female; Glycerides; Glycerol; Leuprolide; Male; Oleic Acid; Propylene Glycol; Rats, Sprague-Dawley; Triglycerides; Trypsin | 2014 |
Enhanced solubility and oral bioavailability of γ-tocotrienol using a self-emulsifying drug delivery system (SEDDS).
Topics: Animals; Antineoplastic Agents; Area Under Curve; Biological Availability; Caco-2 Cells; Chromans; Drug Delivery Systems; Emulsifying Agents; Emulsions; Glycerides; Glycerol; Humans; Lipolysis; Male; Organic Chemicals; Rats, Sprague-Dawley; Solubility; Vitamin E | 2014 |
Improving oral bioavailability of metformin hydrochloride using water-in-oil microemulsions and analysis of phase behavior after dilution.
Topics: Administration, Oral; Animals; Biological Availability; Emulsions; Ethylene Glycols; Glycerides; Glycerol; Hexoses; Hypoglycemic Agents; Intestinal Absorption; Intestinal Mucosa; Linoleic Acids; Male; Metformin; Oleic Acids; Organic Chemicals; Phase Transition; Polysorbates; Rats, Sprague-Dawley; Solubility; Surface-Active Agents; Water | 2014 |
Non-ionic surfactants as novel intranasal absorption enhancers: in vitro and in vivo characterization.
Topics: Administration, Intranasal; Animals; Biological Availability; Chemistry, Pharmaceutical; Glycerol; Laurates; Male; Nasal Absorption; Nasal Mucosa; Poloxamer; Rats; Rats, Sprague-Dawley; Sumatriptan; Surface-Active Agents | 2016 |
On the use of tert-butanol/water cosolvent systems in production and freeze-drying of poly-ε-caprolactone nanoparticles.
Topics: Cryoprotective Agents; Drug Carriers; Excipients; Freeze Drying; Glycerol; Hot Temperature; Italy; Mannitol; Models, Chemical; Nanoparticles; Nanotechnology; Particle Size; Poloxamer; Polyesters; Solvents; Sucrose; Suspensions; tert-Butyl Alcohol; Water | 2015 |
Alphaxalone Reformulated: A Water-Soluble Intravenous Anesthetic Preparation in Sulfobutyl-Ether-β-Cyclodextrin.
Topics: Anesthetics, Intravenous; Animals; Arterial Pressure; beta-Cyclodextrins; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Excipients; Glycerol; Heart Rate; Lethal Dose 50; Male; Motor Activity; Pain Threshold; Pregnanediones; Propofol; Rats, Wistar; Reflex; Risk Assessment; Sleep; Solubility; Soybean Oil; Time Factors; Water | 2015 |
Pharmacologic sensitivity of paclitaxel to its delivery vehicles drives distinct clinical outcomes of paclitaxel formulations.
Topics: Albumin-Bound Paclitaxel; Albumins; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Area Under Curve; Chemistry, Pharmaceutical; Clinical Trials as Topic; Drug Carriers; Drug Delivery Systems; Excipients; Glycerol; Humans; Paclitaxel; Pharmaceutical Vehicles; Solvents; Tissue Distribution | 2015 |
Paclitaxel-loaded expansile nanoparticles enhance chemotherapeutic drug delivery in mesothelioma 3-dimensional multicellular spheroids.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carboxylic Acids; Cell Line, Tumor; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Ethanol; Excipients; Fluorescent Dyes; Glycerol; Humans; Kinetics; Lung Neoplasms; Mesothelioma; Mesothelioma, Malignant; Microscopy, Confocal; Nanomedicine; Nanoparticles; Paclitaxel; Pinocytosis; Rhodamines; Spheroids, Cellular; Technology, Pharmaceutical | 2015 |
Another Steroid Hypnotic: More of the Same or Something Different?
Topics: Anesthetics, Intravenous; Animals; beta-Cyclodextrins; Excipients; Glycerol; Male; Pregnanediones; Propofol; Water | 2015 |
Steroid Anesthesia Revisited: Again.
Topics: Anesthetics, Intravenous; Animals; beta-Cyclodextrins; Excipients; Glycerol; Male; Pregnanediones; Propofol; Water | 2015 |
Preparation, characterization and in vivo evaluation of curcumin self-nano phospholipid dispersion as an approach to enhance oral bioavailability.
Topics: Animals; Biological Availability; Curcumin; Drug Compounding; Glycerol; Phospholipids; Polyethylene Glycols; Rats, Wistar; Surface-Active Agents; Triglycerides | 2015 |
Reduced Food-Effect on Intestinal Absorption of Dronedarone by Self-microemulsifying Drug Delivery System (SMEDDS).
Topics: Administration, Oral; Amiodarone; Animals; Anti-Arrhythmia Agents; Castor Oil; Dogs; Dronedarone; Drug Delivery Systems; Emulsions; Food-Drug Interactions; Glycerides; Glycerol; Intestinal Absorption; Male; Polyethylene Glycols; Polysorbates; Surface-Active Agents | 2015 |
Induction of oxidative stress by Taxol® vehicle Cremophor-EL triggers production of interleukin-8 by peripheral blood mononuclear cells through the mechanism not requiring de novo synthesis of mRNA.
Topics: Albumin-Bound Paclitaxel; Animals; Antineoplastic Agents; Cell Line; Glycerol; Humans; Interleukin-8; Leukocytes, Mononuclear; Mice; Oxidative Stress; Paclitaxel; Pharmaceutical Vehicles; Polyethylene Glycols | 2015 |
Formulation and evaluation of Itraconazole nanoemulsion for enhanced oral bioavailability.
Topics: Administration, Oral; Animals; Antifungal Agents; Biological Availability; Diffusion; Emulsions; Excipients; Glycerides; Glycerol; Itraconazole; Kinetics; Male; Microscopy, Confocal; Microscopy, Electron, Transmission; Nanomedicine; Particle Size; Permeability; Poloxamer; Rats; Rats, Sprague-Dawley; Surface-Active Agents; Temperature | 2015 |
Use of solubilizers in preclinical formulations: Effect of Cremophor EL on the pharmacokinetic properties on early discovery compounds.
Topics: Administration, Topical; Animals; Chemistry, Pharmaceutical; Drug Evaluation, Preclinical; Glycerol; Half-Life; Male; Mice; Mice, Inbred BALB C; Pharmaceutical Preparations; Rats; Rats, Sprague-Dawley; Solvents | 2016 |
Comparison of complement activation-related pseudoallergy in miniature and domestic pigs: foundation of a validatable immune toxicity model.
Topics: Amphotericin B; Animals; Complement Activation; Disease Models, Animal; Doxorubicin; Drug Hypersensitivity; Glycerol; Humans; Liposomes; Nanomedicine; Nanoparticles; Polyethylene Glycols; Swine; Swine, Miniature; Zymosan | 2016 |
Cremophor EL-based nanoemulsion enhances transcellular permeation of emodin through glucuronidation reduction in UGT1A1-overexpressing MDCKII cells.
Topics: Animals; Dogs; Drug Liberation; Emodin; Emulsions; Endocytosis; Glucuronides; Glucuronosyltransferase; Glycerol; Madin Darby Canine Kidney Cells; Nanostructures | 2016 |
Novel Water-Borne Polyurethane Nanomicelles for Cancer Chemotherapy: Higher Efficiency of Folate Receptors Than TRAIL Receptors in a Cancerous Balb/C Mouse Model.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Drug Carriers; Drug Compounding; Female; Folic Acid; Folic Acid Transporters; Glycerol; Ligands; Mice, Inbred BALB C; Micelles; Nanomedicine; Nanoparticles; Paclitaxel; Polyurethanes; Receptors, TNF-Related Apoptosis-Inducing Ligand; Solubility; Technology, Pharmaceutical; Time Factors; TNF-Related Apoptosis-Inducing Ligand; Tumor Burden | 2016 |
Development of intranasal nanovehicles of itraconazole and their immunological activities for the therapy of rhinovirus infection.
Topics: Administration, Intranasal; Animals; Antifungal Agents; Benzyl Alcohol; Chemistry, Pharmaceutical; Drug Carriers; Drug Delivery Systems; Drug Liberation; Emulsions; Female; Glycerol; Host-Pathogen Interactions; Humans; Itraconazole; Mice, Inbred BALB C; Microscopy, Electron, Transmission; Nanoparticles; Particle Size; Picornaviridae Infections; Polyethylene Glycols; Rhinovirus; Stearic Acids; Water | 2016 |
Enhanced dissolution and oral absorption of tacrolimus by supersaturable self-emulsifying drug delivery system.
Topics: Administration, Oral; Animals; Diglycerides; Drug Carriers; Drug Delivery Systems; Emulsions; Ethylene Glycols; Glycerol; Male; Monoglycerides; Polyethylene Glycols; Polyvinyls; Rats, Sprague-Dawley; Solubility; Surface-Active Agents; Tacrolimus | 2016 |
Cytotoxicity assessment of lipid-based self-emulsifying drug delivery system with Caco-2 cell model: Cremophor EL as the surfactant.
Topics: Caco-2 Cells; Cell Survival; Drug Delivery Systems; Emulsions; Esters; Excipients; Glycerol; Humans; Lipids; Particle Size; Propylene Glycol; Surface-Active Agents | 2016 |
The Monoglyceride Content Affects the Self-Assembly Behavior, Rheological Properties, Syringeability, and Mucoadhesion of In Situ-Gelling Liquid Crystalline Phase.
Topics: Animals; Drug Carriers; Drug Delivery Systems; Gels; Glycerol; In Vitro Techniques; Liquid Crystals; Monoglycerides; Mouth Mucosa; Rheology; Sus scrofa; Syringes; Tissue Adhesives | 2016 |
A new mechanism for increasing the oral bioavailability of scutellarin with Cremophor EL: Activation of MRP3 with concurrent inhibition of MRP2 and BCRP.
Topics: Adenosine Triphosphatases; Animals; Apigenin; ATP Binding Cassette Transporter, Subfamily G, Member 2; Biological Availability; Dogs; Glucuronates; Glycerol; Madin Darby Canine Kidney Cells; Male; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Rats, Sprague-Dawley | 2016 |
Novel oral administrated paclitaxel micelles with enhanced bioavailability and antitumor efficacy for resistant breast cancer.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Benzylisoquinolines; Breast Neoplasms; Caco-2 Cells; Cell Cycle; Drug Resistance, Neoplasm; Female; Glycerol; Humans; Male; MCF-7 Cells; Mice; Mice, Nude; Micelles; Neoplasm Transplantation; Paclitaxel; Particle Size; Rats; Rats, Sprague-Dawley; Solubility | 2017 |
Self-Nanoemulsified Drug Delivery System of Hydrochlorothiazide for Increasing Dissolution Rate and Diuretic Activity.
Topics: Diuretics; Drug Delivery Systems; Emulsions; Glycerol; Hydrochlorothiazide; Solubility | 2017 |
Transdermal delivery of atorvastatin calcium from novel nanovesicular systems using polyethylene glycol fatty acid esters: Ameliorated effect without liver toxicity in poloxamer 407-induced hyperlipidemic rats.
Topics: Administration, Cutaneous; Animals; Atorvastatin; Biological Availability; Chemistry, Pharmaceutical; Cholesterol; Drug Delivery Systems; Drug Liberation; Esters; Fatty Acids; Glycerides; Glycerol; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Lecithins; Liver; Male; Nanocapsules; Particle Size; Permeability; Poloxamer; Polyethylene Glycols; Polysorbates; Rats, Wistar; Skin Absorption; Transdermal Patch | 2017 |
Studies of the precipitation pattern of paclitaxel in intravenous infusions and rat plasma using laser nephelometry.
Topics: Albumins; Animals; Antineoplastic Agents, Phytogenic; Chemistry, Pharmaceutical; Drug Carriers; Glycerol; Infusions, Intravenous; Lasers; Neoplasms; Nephelometry and Turbidimetry; Paclitaxel; Plasma; Rats; Rats, Wistar | 2018 |
Formulation Screening and Freeze-Drying Process Optimization of Ginkgolide B Lyophilized Powder for Injection.
Topics: Desiccation; Excipients; Freeze Drying; Freezing; Ginkgolides; Glycerol; Injections; Lactones; Mannitol; Polyethylene Glycols; Powders; Reproducibility of Results; Solubility; Solvents; Temperature; Transition Temperature | 2018 |
Formulation and in vivo assessment of terconazole-loaded polymeric mixed micelles enriched with Cremophor EL as dual functioning mediator for augmenting physical stability and skin delivery.
Topics: Animals; Animals, Newborn; Antifungal Agents; Drug Carriers; Drug Compounding; Drug Delivery Systems; Drug Stability; Glycerol; Male; Micelles; Organ Culture Techniques; Rats; Rats, Wistar; Skin Absorption; Surface-Active Agents; Triazoles | 2018 |
Biopharmaceutical evaluation of surface active ophthalmic excipients using in vitro and ex vivo corneal models.
Topics: Administration, Ophthalmic; Animals; Biopharmaceutics; Cell Line; Chloramphenicol; Dexamethasone; Diclofenac; Drug Compounding; Dynamic Light Scattering; Electric Impedance; Epithelium, Corneal; Excipients; Female; Glycerol; Humans; Male; Ocular Absorption; Ophthalmic Solutions; Permeability; Pharmaceutical Preparations; Poloxamer; Polyethylene Glycols; Polysorbates; Surface-Active Agents; Sus scrofa; Technology, Pharmaceutical; Time Factors; Timolol | 2018 |
Ionic-Liquid-Based Paclitaxel Preparation: A New Potential Formulation for Cancer Treatment.
Topics: Antineoplastic Agents, Phytogenic; Drug Compounding; Drug Delivery Systems; Drug Hypersensitivity; Excipients; Glycerol; HeLa Cells; Humans; Ionic Liquids; Neoplasms; Paclitaxel; Solubility | 2018 |
Polymeric Micelles Based on Modified Glycol Chitosan for Paclitaxel Delivery: Preparation, Characterization and Evaluation.
Topics: alpha-Tocopherol; Animals; Antineoplastic Agents; Chitosan; Drug Delivery Systems; Female; Glycerol; Humans; Injections, Intravenous; Male; MCF-7 Cells; Mice; Micelles; Paclitaxel; Particle Size; Polymers; Proton Magnetic Resonance Spectroscopy; Rabbits; Spectroscopy, Fourier Transform Infrared; Static Electricity; X-Ray Diffraction | 2018 |
Liposomal paclitaxel induces fewer hematopoietic and cardiovascular complications than bioequivalent doses of Taxol.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cardiovascular Diseases; Cell Line, Tumor; Cell Survival; Drug Carriers; Drug Compounding; Drug Liberation; Drug Screening Assays, Antitumor; Female; Glycerol; Hematologic Diseases; Humans; Liposomes; Male; Mice; Mice, Inbred ICR; Mice, SCID; Neutropenia; Paclitaxel; Therapeutic Equivalency; Tissue Distribution | 2018 |
Stabilization benefits of single and multi-layer self-nanoemulsifying pellets: A poorly-water soluble model drug with hydrolytic susceptibility.
Topics: Cinnarizine; Dosage Forms; Drug Compounding; Drug Delivery Systems; Drug Stability; Emulsions; Glycerol; Nanoparticles; Oleic Acid; Povidone; Silicon Dioxide; Solubility; Water | 2018 |
Modulation of Intestinal Transport and Absorption of Topotecan, a BCRP Substrate, by Various Pharmaceutical Excipients and Their Inhibitory Mechanisms of BCRP Transporter.
Topics: Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; Biological Availability; Caco-2 Cells; Excipients; Glycerides; Glycerol; Humans; Intestinal Absorption; Lipid Bilayers; Male; Neoplasm Proteins; Poloxamer; Polysorbates; Rats; Topotecan | 2019 |
Formulation, optimization, hemocompatibility and pharmacokinetic evaluation of PLGA nanoparticles containing paclitaxel.
Topics: Animals; Chemistry, Pharmaceutical; Drug Carriers; Drug Delivery Systems; Female; Glycerol; Humans; Nanoparticles; Paclitaxel; Particle Size; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rats; Rats, Wistar; Solvents; Surface-Active Agents; Technology, Pharmaceutical | 2019 |
A Nonionic Polyethylene Oxide (PEO) Surfactant Model: Experimental and Molecular Dynamics Studies of Kolliphor EL.
Topics: Chemistry, Pharmaceutical; Cryoelectron Microscopy; Digestion; Excipients; Glycerol; Micelles; Models, Biological; Models, Chemical; Molecular Dynamics Simulation; Nephelometry and Turbidimetry; Solutions; Surface-Active Agents | 2019 |
A Novel Dantrolene Sodium-Loaded Mixed Micelle Containing a Small Amount of Cremophor EL: Characterization, Stability, Safety and Pharmacokinetics.
Topics: Animals; Biological Transport; Dantrolene; Drug Carriers; Drug Compounding; Drug Liberation; Drug Stability; Glycerol; Male; Micelles; Molecular Structure; Particle Size; Phospholipids; Rats, Sprague-Dawley; Solubility; Surface Properties; Water | 2019 |
Effects of Cremophor EL/ethanol/oleinic acid/water microemulsion on human blood components and coagulation function.
Topics: Blood Coagulation; Dynamic Light Scattering; Emulsions; Erythrocytes; Ethanol; Glycerol; Hemolysis; Humans; Kinetics; Oleic Acid; Partial Thromboplastin Time; Particle Size; Protein Structure, Secondary; Prothrombin Time; Serum Albumin, Human; Static Electricity; Temperature; Thrombelastography; Water | 2019 |
In vivo biocompatibility, pharmacokinetics, antitumor efficacy, and hypersensitivity evaluation of ionic liquid-mediated paclitaxel formulations.
Topics: Administration, Intravenous; Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Drug Delivery Systems; Drug Hypersensitivity; Female; Glycerol; Ionic Liquids; Melanoma; Mice, Inbred C57BL; Paclitaxel; Skin Neoplasms | 2019 |
Synergistic effects of a cremophor EL drug delivery system and its U0126 cargo in an
Topics: Animals; Butadienes; Drug Carriers; Drug Synergism; Female; Glycerol; Male; MAP Kinase Signaling System; Models, Biological; Nitriles; Rats; Rats, Sprague-Dawley; Receptor, Endothelin B; Up-Regulation | 2019 |
Pharmacokinetic modeling of the blood-stable camptothecin analog AR-67 in two different formulations.
Topics: Animals; Antineoplastic Agents, Phytogenic; beta-Cyclodextrins; Camptothecin; Excipients; Glycerol; Male; Mice; Mice, Inbred C57BL; Models, Biological; Organosilicon Compounds; Tissue Distribution | 2019 |
Cremophor EL Nano-Emulsion Monomerizes Chlorophyll
Topics: Buffers; Chlorophyll A; Emulsions; Ethanol; Glycerol; Nanoparticles; Phosphates; Surface-Active Agents; Water | 2019 |
In Vitro Effects of Paclitaxel and Cremophor EL on Human Riboflavin Transporter SLC52A2.
Topics: Antineoplastic Agents, Phytogenic; Glycerol; HEK293 Cells; Humans; Paclitaxel; Receptors, G-Protein-Coupled; Riboflavin | 2020 |
Mast cells activation and high blood tryptase levels due to paclitaxel administration. Is Cremophor EL the culprit?: A case report.
Topics: Aged; Drug Hypersensitivity; Glycerol; Humans; Male; Mast Cells; Paclitaxel; Tryptases; Urologic Neoplasms | 2020 |
Stability of Chlorophyll
Topics: Chlorophyll A; Darkness; Glycerol; Light; Micelles | 2020 |
Evaluation of the efficacy and safety of a new formulation-lipid emulsion-based PTX injection: Pharmacokinetics, tissue distributions and anticancer effect on human gastric cancer cells in vitro.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Chromatography, High Pressure Liquid; Emulsions; Female; Glycerol; Humans; Lipids; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Paclitaxel; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry; Tissue Distribution; Xenograft Model Antitumor Assays | 2021 |
Pharmacokinetic study of an anti-trypanosome agent with different formulations and administration routes in mice by HPLC-MS/MS.
Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Glycerol; Injections, Intraperitoneal; Linear Models; Male; Mice; Reproducibility of Results; Sensitivity and Specificity; Sesame Oil; Tandem Mass Spectrometry; Trypanocidal Agents | 2021 |
Excipient knowledgebase: Development of a comprehensive tool for understanding the disposition and interaction potential of common excipients.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Computer Simulation; Cytochrome P-450 CYP3A; Drug Interactions; Excipients; Glycerol; Humans; Knowledge Bases; Models, Biological | 2021 |
New potential application of hydroxypropyl-β-cyclodextrin in solid self-nanoemulsifying drug delivery system and solid dispersion.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Animals; Corn Oil; Drug Carriers; Emulsions; Glycerol; Ibuprofen; Male; Polysorbates; Rats, Sprague-Dawley; Solubility | 2021 |