Page last updated: 2024-08-24

cremophor el and cyclosporine

cremophor el has been researched along with cyclosporine in 37 studies

Research

Studies (37)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	20 (54.05)	18.2507
2000's	14 (37.84)	29.6817
2010's	3 (8.11)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Ilhan, M; Tuncer, M; Yaris, E	1
Chester, A; Mankad, P; O'Neil, G; Slavik, Z; Spatenka, J; Yacoub, M	1
Brat, DJ; Brimijoin, S; Windebank, AJ	1
Yee, GC	1
Beliveau, R; Jetté, L; Leclerc, JM; Murphy, GF	1
Chan, HS; Doyle, J; Greenberg, ML; Koren, G; Liau-Chu, M; Theis, JG	1
Osann, K; Slater, L; Stupecky, M; Sweet, P; Wetzel, M	1
Tuncer, M; Yaris, E	1
Baker, RM; Brecher, ML; Chervinsky, DS; Hoelcle, MJ; Tebbi, CK	1
Lodge, NJ	1
Blexrud, MD; de Groen, PC; Windebank, AJ	1
Cornblatt, B; Lee, EJ; Levy, C; Ross, DD; Schiffer, CA; Sridhara, R; Tong, Y; Wooten, PJ	1
Alvestrand, A; Larsson, M; Tibell, A	1
Ge, X; McCarthy, ET; Savin, VJ; Sharma, M; Sharma, R	1
Windebank, AJ	1
Dahlback, M; Eirefelt, S; Karlsson, BW; Lundin, PD; Pierzynowski, SG; Podlesny, J; Siwinska-Golebiowska, H; Taljanski, W; Westrom, BR	1
Brinkmann, T; Kleesiek, K; Körfer, R; Körner, M; Prohaska, W; Tiemann, C	1
Koren, G; Liau-Chu, M; Theis, JG	1
Michaud, LB	1
Canada, AL; Ross, HJ; Slater, LM	1
Escousse, A; Gouyon, JB; Guignard, JP; Justrabo, E; Prévot, A; Semama, DS	1
Cloarec, A; Cornaire, G; Decourt, S; Houin, G; Legendre, JY; Saivin, S; Woodley, JF	1
Bessard, G; Deveaux, G; Devillier, P; Hardy, G; Sessa, C; Stanke-Labesque, F	1
Sparreboom, A; van Zuylen, L; Verweij, J	1
Meyer, D; van der Bijl, P; van Eyk, AD	1
Bardelmeijer, HA; Beijnen, JH; Koopman, FJ; Malingré, MM; Ouwehand, M; Rosing, H; Schellens, JH; Schot, ME; Ten Bokkel Huinink, WW; Van Tellingen, O	1
Engelbrecht, AH; Meyer, D; Van Der Bijl, P; Van Eyk, AD	1
Beijnen, JH; Boogerd, W; Cleypool, C; Kemper, EM; Mos, HA; van Tellingen, O; van Zandbergen, AE	1
Dyck, J; English, D; Kerjner, A; Lai, JC; Loo, S; McDonald, PC; McManus, BM; Moghadasian, MH; Tranfield, EM; Walker, DC; Wilson, JE; Wong, D	1
Chang, EJ; Mun, KC	1
Furukawa, H; Ishizaki, J; Jin, M; Miyamoto, K; Mizuhara, Y; Nomura, M; Shimada, T; Yokogawa, K	1
Aliabadi, HM; Lavasanifar, A; Mahmud, A; Sharifabadi, AD	1
Connor, HD; Forman, DT; Lemasters, JJ; Li, X; Mason, RP; Thurman, RG; Zhong, Z	1
Chen, JS; Chen, PM; Chu, Z; Figg, WD; Gardner, ER; Liau, CT; Lin, YC; Sparreboom, A; Wang, HM; Yang, MH	1
Atilla, P; Bolay, H; Cakar, AN; Dalkara, T; Emre-Aydıngöz, S; Erdem, SR; Tuncer, M	1
Dufour, S; Geny, B; Kindo, M; Lampert, E; Mettauer, B; N' Guessan, BB; Ribera, F; Sanchez, H; Ventura-Clapier, R; Zoll, J	1
Ehinger, KH; Elmér, E; Hansson, MJ; Sjövall, F	1

Reviews

3 review(s) available for cremophor el and cyclosporine

Article	Year
Dosage forms of cyclosporine. Pharmacotherapy, 1991, Volume: 11, Issue:6 Topics: Administration, Oral; Capsules; Cyclosporine; Drug Stability; Glycerol; Humans; Injections, Intravenous; Solutions	1991
Methods for preventing reactions secondary to Cremophor EL. The Annals of pharmacotherapy, 1997, Volume: 31, Issue:11 Topics: Anaphylaxis; Chemistry, Pharmaceutical; Cyclosporine; Drug Compounding; Glycerol; Humans; Pharmaceutical Vehicles	1997
Role of formulation vehicles in taxane pharmacology. Investigational new drugs, 2001, Volume: 19, Issue:2 Topics: Animals; Anthracyclines; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chemistry, Pharmaceutical; Cyclosporine; Drug Hypersensitivity; Drug Resistance, Multiple; Glycerol; Humans; Micelles; Neoplasms; Nervous System Diseases; Paclitaxel; Polysorbates; Surface-Active Agents	2001

Trials

5 trial(s) available for cremophor el and cyclosporine

Article	Year
Anaphylactoid reactions in children receiving high-dose intravenous cyclosporine for reversal of tumor resistance: the causative role of improper dissolution of Cremophor EL. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1995, Volume: 13, Issue:10 Topics: Adolescent; Anaphylaxis; Antineoplastic Combined Chemotherapy Protocols; Azo Compounds; Child; Child, Preschool; Cyclosporine; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Ethanol; Glycerol; Humans; Immunosuppressive Agents; Infusions, Intravenous; Pharmaceutical Vehicles; Premedication; Rhabdomyosarcoma; Solubility; Solvents; Statistics, Nonparametric	1995
The co-solvent Cremophor EL limits absorption of orally administered paclitaxel in cancer patients. British journal of cancer, 2001, Nov-16, Volume: 85, Issue:10 Topics: Administration, Oral; Antineoplastic Agents, Phytogenic; Area Under Curve; Cyclosporine; Drug Combinations; Feces; Glycerol; Humans; Intestinal Absorption; Neoplasms; Paclitaxel; Pharmaceutical Vehicles; Polysorbates; Solvents	2001
Oral bioavailability of a novel paclitaxel formulation (Genetaxyl) administered with cyclosporin A in cancer patients. Anti-cancer drugs, 2008, Volume: 19, Issue:3 Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents, Phytogenic; Area Under Curve; Biological Availability; Cyclosporine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Glycerol; Humans; Immunosuppressive Agents; Infusions, Intravenous; Male; Middle Aged; Neoplasms; Paclitaxel	2008
Oxidative capacities of cardiac and skeletal muscles of heart transplant recipients: mitochondrial effects of cyclosporin-A and its vehicle Cremophor-EL. Fundamental & clinical pharmacology, 2014, Volume: 28, Issue:2 Topics: Cyclosporine; Dose-Response Relationship, Drug; Electron Transport; Electron Transport Chain Complex Proteins; Female; Glycerol; Heart Transplantation; Humans; Immunosuppressive Agents; Male; Middle Aged; Mitochondria, Heart; Mitochondria, Muscle; Muscle, Skeletal; Myocardium; Oxygen Consumption; Pharmaceutical Vehicles; Transplants	2014
Bioequivalence and tolerability assessment of a novel intravenous ciclosporin lipid emulsion compared to branded ciclosporin in Cremophor ® EL. Clinical drug investigation, 2013, Volume: 33, Issue:1 Topics: Adolescent; Adult; Area Under Curve; Biological Availability; Chemistry, Pharmaceutical; Cross-Over Studies; Cyclosporine; Emulsifying Agents; Excipients; Fat Emulsions, Intravenous; Female; Glycerol; Half-Life; Humans; Immunosuppressive Agents; Infusions, Intravenous; Male; Metabolic Clearance Rate; Middle Aged; South Africa; Therapeutic Equivalency; Young Adult	2013

Other Studies

29 other study(ies) available for cremophor el and cyclosporine

Article	Year
Actions of cyclosporin A preparation and Cremophor-EL in rabbit mesenteric artery and thoracic aorta in vitro. Clinical science (London, England : 1979), 1992, Volume: 83, Issue:2 Topics: Acetylcholine; Animals; Aorta, Thoracic; Cyclosporine; Drug Synergism; Glycerol; In Vitro Techniques; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; Phenylephrine; Rabbits; Solvents; Vasoconstriction; Vasodilation	1992
Acute effects of cyclosporin and cremophor EL on endothelial function and vascular smooth muscle in the isolated rat heart. Cardiovascular drugs and therapy, 1992, Volume: 6, Issue:1 Topics: Animals; Coronary Circulation; Cyclosporine; Endothelium, Vascular; Glycerol; Heart; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Perfusion; Pharmaceutical Vehicles; Rats; Rats, Inbred Strains	1992
Emulsifier for intravenous cyclosporin inhibits neurite outgrowth, causes deficits in rapid axonal transport and leads to structural abnormalities in differentiating N1E.115 neuroblastoma. The Journal of pharmacology and experimental therapeutics, 1992, Volume: 261, Issue:2 Topics: Animals; Cell Differentiation; Cyclosporine; Glycerol; Mice; Neurites; Neuroblastoma; Pharmaceutical Vehicles; Tumor Cells, Cultured; Video Recording	1992
Interaction of drugs with P-glycoprotein in brain capillaries. Biochemical pharmacology, 1995, Nov-09, Volume: 50, Issue:10 Topics: Affinity Labels; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Blood-Brain Barrier; Brain; Capillaries; Cyclosporine; Cyclosporins; Drug Interactions; Glycerol; In Vitro Techniques; Iodine Radioisotopes; Male; Prazosin; Rats; Rats, Sprague-Dawley; Time Factors; Tritium	1995
Comparison of cyclosporin A, verapamil, PSC-833 and cremophor EL as enhancing agents of VP-16 in murine lymphoid leukemias. Leukemia research, 1995, Volume: 19, Issue:8 Topics: Animals; Cell Survival; Cyclosporine; Cyclosporins; Drug Synergism; Etoposide; Glycerol; Leukemia L1210; Leukemia P388; Mice; Survival Analysis; Tumor Cells, Cultured; Verapamil	1995
The effect of indomethacin on cyclosporin A- and its solvent-induced inhibition of endothelium-dependent relaxation and the drug-induced contraction of rabbit isolated arteries. General pharmacology, 1995, Volume: 26, Issue:1 Topics: Acetylcholine; Animals; Cyclosporine; Endothelium, Vascular; Glycerol; In Vitro Techniques; Indomethacin; Male; Pharmaceutical Vehicles; Rabbits; Vasoconstriction; Vasodilation	1995
Reversal of C1300 murine neuroblastoma multidrug resistance by cremophorEL, a solvent for cyclosporin A. Cancer biotherapy, 1993,Spring, Volume: 8, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Division; Chromatography, High Pressure Liquid; Clone Cells; Cyclosporine; Doxorubicin; Drug Interactions; Drug Resistance, Multiple; Glycerol; Harringtonines; Homoharringtonine; Intracellular Fluid; Mice; Neuroblastoma; Pharmaceutical Vehicles; Solvents; Tumor Cells, Cultured	1993
Direct vasoconstrictor effects of sandimmune (cyclosporine A) are mediated by its vehicle cremophor EL: inhibition by the thromboxane A2/prostaglandin endoperoxide receptor antagonist ifetroban. The Journal of pharmacology and experimental therapeutics, 1994, Volume: 271, Issue:2 Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cyclosporine; Dose-Response Relationship, Drug; Glyburide; Glycerol; In Vitro Techniques; Male; Oxazoles; Pharmaceutical Vehicles; Propionates; Rabbits; Receptors, Thromboxane; Ricinoleic Acids; Vasoconstrictor Agents	1994
Potential neurotoxicity of the solvent vehicle for cyclosporine. The Journal of pharmacology and experimental therapeutics, 1994, Volume: 268, Issue:2 Topics: Animals; Cyclosporine; Demyelinating Diseases; Ethanol; Female; Ganglia, Spinal; Glycerol; Humans; Nervous System; Pharmaceutical Vehicles; Pregnancy; Rats; Rats, Sprague-Dawley	1994
Synergistic reversal of multidrug-resistance phenotype in acute myeloid leukemia cells by cyclosporin A and cremophor EL. Blood, 1994, Mar-01, Volume: 83, Issue:5 Topics: Cell Survival; Cyclosporine; Daunorubicin; Drug Resistance; Drug Synergism; Female; Glycerol; Humans; Leukemia, Myeloid, Acute; Male; Tumor Cells, Cultured	1994
Dissolving intravenous cyclosporin A in a fat emulsion carrier prevents acute renal side effects in the rat. Transplant international : official journal of the European Society for Organ Transplantation, 1993, Volume: 6, Issue:2 Topics: Animals; Cyclosporine; Drug Carriers; Emulsions; Glomerular Filtration Rate; Glycerol; Infusions, Intravenous; Kidney; Kidney Diseases; Male; Rats; Rats, Wistar; Solubility; Soybean Oil	1993
Cyclosporine protects glomeruli from FSGS factor via an increase in glomerular cAMP. Transplantation, 1996, Dec-27, Volume: 62, Issue:12 Topics: Albumins; Animals; Cyclic AMP; Cyclosporine; Glomerulosclerosis, Focal Segmental; Glycerol; Humans; Kidney Glomerulus; Male; Microscopy, Electron; Permeability; Rats; Rats, Sprague-Dawley; Sodium Chloride	1996
The vehicle for cyclosporine is neurotoxic in vitro. Annals of neurology, 1997, Volume: 41, Issue:4 Topics: Animals; Axons; Cells, Cultured; Cyclosporine; Demyelinating Diseases; Glycerol; Humans; Neurons; Oligodendroglia; Pharmaceutical Vehicles	1997
Pulmonary delivery of intratracheally instilled and aerosolized cyclosporine A to young and adult rats. Drug metabolism and disposition: the biological fate of chemicals, 1997, Volume: 25, Issue:8 Topics: Aerosols; Aging; Animals; Biological Availability; Cyclosporine; Female; Glycerol; Half-Life; Lung; Male; Rats; Rats, Sprague-Dawley; Trachea	1997
Effect of cyclosporine A on the release of tissue factor pathway inhibitor from endothelial cells in heart transplant patients and cell culture. European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies, 1997, Volume: 35, Issue:9 Topics: Adolescent; Adult; Calcimycin; Calcium; Cell Division; Cells, Cultured; Cyclosporine; Endothelium, Vascular; Female; Glycerol; Heart Transplantation; Humans; Ionophores; Lipoproteins; Male; Middle Aged; Pharmaceutical Vehicles; von Willebrand Factor	1997
Mechanism of anaphylactoid reactions: improper preparation of high-dose intravenous cyclosporine leads to bolus infusion of Cremophor EL and cyclosporine. The Annals of pharmacotherapy, 1997, Volume: 31, Issue:11 Topics: Anaphylaxis; Chemistry, Pharmaceutical; Cyclosporine; Drug Compounding; Ethanol; Glycerol; Humans; Pharmaceutical Vehicles; Solutions	1997
Cyclosporin A enhances paclitaxel toxicity against leukemia and respiratory epithelial cancers. Clinical cancer research : an official journal of the American Association for Cancer Research, 1997, Volume: 3, Issue:1 Topics: Animals; Antineoplastic Agents, Phytogenic; Cyclosporine; Cytokines; Disease Models, Animal; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Glycerol; Growth Substances; Humans; Immunosuppressive Agents; Leukemia; Mice; Paclitaxel; Respiratory Tract Neoplasms; Survival Rate; Treatment Outcome; Tumor Cells, Cultured	1997
Acute cyclosporine A-induced nephrotoxicity: a rabbit model. Pediatric nephrology (Berlin, Germany), 2000, Volume: 14, Issue:5 Topics: Acute Disease; Animals; Cyclosporine; Glycerol; Kidney; Kidney Diseases; Male; Rabbits; Renal Circulation; Surface-Active Agents	2000
Effect of polyoxyl 35 castor oil and Polysorbate 80 on the intestinal absorption of digoxin in vitro. Arzneimittel-Forschung, 2000, Volume: 50, Issue:6 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cardiotonic Agents; Cyclosporine; Digoxin; Glycerol; In Vitro Techniques; Intestinal Absorption; Intestine, Small; L-Lactate Dehydrogenase; Micelles; Polysorbates; Rats; Surface-Active Agents	2000
Cyclosporine A and cremophor EL induce contractions of human saphenous vein: involvement of thromboxane A2 receptor-dependent pathway. Journal of cardiovascular pharmacology, 2000, Volume: 36, Issue:6 Topics: Biphenyl Compounds; Cyclosporine; Fibrinolytic Agents; Glycerol; Heptanoic Acids; Humans; Immunosuppressive Agents; In Vitro Techniques; Lipoxygenase Inhibitors; Muscle Contraction; Muscle, Smooth, Vascular; Pharmaceutical Vehicles; Receptors, Thromboxane; Saphenous Vein	2000
Effects of three penetration enhancers on transcorneal permeation of cyclosporine. Cornea, 2001, Volume: 20, Issue:5 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Benzalkonium Compounds; Biological Availability; Biological Transport; Cornea; Cyclosporine; Dimethyl Sulfoxide; Glycerol; Humans; Immunosuppressive Agents; Middle Aged; Permeability; Pharmaceutical Vehicles	2001
Comparative permeability of human and rabbit corneas to cyclosporin and tritiated water. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2002, Volume: 18, Issue:5 Topics: Animals; Benzalkonium Compounds; Cornea; Culture Techniques; Cyclosporine; Dimethyl Sulfoxide; Female; Frozen Sections; Glycerol; Humans; Immunosuppressive Agents; Male; Models, Biological; Permeability; Rabbits; Time Factors; Tritium; Water	2002
Increased penetration of paclitaxel into the brain by inhibition of P-Glycoprotein. Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Volume: 9, Issue:7 Topics: Acridines; Animals; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Chromatography, High Pressure Liquid; Clinical Trials as Topic; Cyclosporine; Cyclosporins; Dose-Response Relationship, Drug; Female; Glycerol; Mice; Mice, Knockout; Paclitaxel; Tetrahydroisoquinolines; Time Factors	2003
Ultrastructural evidence of early endothelial damage in coronary arteries of rat cardiac allografts. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2003, Volume: 22, Issue:9 Topics: Animals; Aorta; Coronary Vessels; Cyclosporine; Disease Models, Animal; Endothelium, Vascular; Glycerol; Heart Transplantation; Immunosuppressive Agents; Male; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Pharmaceutical Vehicles; Rats; Rats, Inbred Lew; Silver Staining; Surface-Active Agents	2003
Effect of melatonin on the malondialdehyde level of neutrophils in cyclosporine-treated rats. Transplantation proceedings, 2004, Volume: 36, Issue:7 Topics: Animals; Cyclosporine; Glycerol; Male; Malondialdehyde; Melatonin; Neutrophils; Rats; Rats, Sprague-Dawley	2004
Cremophor EL releases cyclosporin A adsorbed on blood cells and blood vessels, and increases apparent plasma concentration of cyclosporin A. International journal of pharmaceutics, 2005, Apr-11, Volume: 293, Issue:1-2 Topics: Adsorption; Animals; Blood Cells; Blood Vessels; Cyclosporine; Glycerol; Male; Rats; Rats, Wistar	2005
Micelles of methoxy poly(ethylene oxide)-b-poly(epsilon-caprolactone) as vehicles for the solubilization and controlled delivery of cyclosporine A. Journal of controlled release : official journal of the Controlled Release Society, 2005, May-18, Volume: 104, Issue:2 Topics: Cyclosporine; Glycerol; Micelles; Pharmaceutical Vehicles; Polyesters; Solubility	2005
Reduction of ciclosporin and tacrolimus nephrotoxicity by plant polyphenols. The Journal of pharmacy and pharmacology, 2006, Volume: 58, Issue:11 Topics: Aldehydes; Animals; Camellia sinensis; Chromatography, High Pressure Liquid; Cyclosporine; Flavonoids; Free Radicals; Glomerular Filtration Rate; Glycerol; Immunohistochemistry; Immunosuppressive Agents; Kidney; Kidney Diseases; Male; Olive Oil; Phenols; Phytotherapy; Plant Oils; Polyphenols; Rats; Rats, Sprague-Dawley; Tacrolimus	2006
Cyclosporine A-induced acute hepatotoxicity in guinea pigs is associated with endothelin-mediated decrease in local hepatic blood flow. Life sciences, 2011, Apr-25, Volume: 88, Issue:17-18 Topics: Animals; Bosentan; Cyclosporine; Dose-Response Relationship, Drug; Endothelins; Female; Glycerol; Guinea Pigs; Liver; Liver Circulation; Male; Peptides, Cyclic; Sulfonamides	2011