Page last updated: 2024-08-25

cp094 and deferiprone

cp094 has been researched along with deferiprone in 19 studies

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's16 (84.21)18.2507
2000's2 (10.53)29.6817
2010's1 (5.26)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
el-Jammal, A; Howell, PL; Li, N; Templeton, DM; Turner, MA1
Dobbin, PS; Hall, AD; Hider, RC; Porter, JB; Sarpong, P; Taylor, PD; van der Helm, D; Xiao, G1
Dekhordi, LS; Hider, RC; Jin, Y; Khodr, H; Liu, Z; Rai, BL1
Hider, RC; Khodr, HH; Liu, DY; Liu, ZD; Lu, SL1
Carrupt, PA; Crivori, P; Cruciani, G; Testa, B1
Dehkordi, LS; Hider, RC; Liu, ZD1
Fakih, S; Francis, PT; Gaeta, A; Hider, RC; Kong, XL; Molina-Holgado, F; Salvage, S; Williams, RJ1
Crichton, RR; Florence, A; Peters, TJ; Ward, RJ1
Bergeron, RJ; Creary, EA; Luchetta, G; Peter, HH; Streiff, RR; Wiegand, J1
Grady, RW; Hershko, C; Hider, RC; Link, G; Peter, HH; Zevin, S1
Caisová, D; Eybl, V; Kontoghiorghes, GJ; Koutenský, J1
Brissot, P; Chenoufi, N; Cillard, J; Hubert, N; Lescoat, G; Loréal, O; Morel, I; Pasdeloup, N1
Choudhury, R; Singh, S1
Olivieri, NF; Parkes, JG; Randell, EW; Templeton, DM1
Boelaert, J; Papavassiliou, P; Soteriadou, K; Voyiatzaki, C1
Hershko, C; Link, G; Pinson, A1
Boelaert, JR; Crichton, RR; de Locht, M; Schneider, YJ; Van Cutsem, J1
Allen, DD; Fredenburg, AM; Sethi, RK; Yokel, RA1
Berthon, G; Biron, F; Desroches, S1

Other Studies

19 other study(ies) available for cp094 and deferiprone

ArticleYear
Copper complexation by 3-hydroxypyridin-4-one iron chelators: structural and iron competition studies.
    Journal of medicinal chemistry, 1994, Feb-18, Volume: 37, Issue:4

    Topics: Antithyroid Agents; Copper; Deferiprone; Iron Chelating Agents; Ligands; Potentiometry; Pyridones; Spectrophotometry

1994
Synthesis, physicochemical properties, and biological evaluation of N-substituted 2-alkyl-3-hydroxy-4(1H)-pyridinones: orally active iron chelators with clinical potential.
    Journal of medicinal chemistry, 1993, Aug-20, Volume: 36, Issue:17

    Topics: Administration, Oral; Animals; Crystallography; Deferoxamine; Horses; Humans; Iron; Iron Chelating Agents; Liver; Mice; Pyridones; Rats; Stereoisomerism; Structure-Activity Relationship

1993
Synthesis, physicochemical properties, and evaluation of N-substituted-2-alkyl-3-hydroxy-4(1H)-pyridinones.
    Journal of medicinal chemistry, 1998, Aug-27, Volume: 41, Issue:18

    Topics: Animals; Bile; Ferritins; Iron; Iron Chelating Agents; Male; Molecular Conformation; Pyridones; Rats; Rats, Inbred F344; Solutions; Structure-Activity Relationship

1998
Synthesis, physicochemical characterization, and biological evaluation of 2-(1'-hydroxyalkyl)-3-hydroxypyridin-4-ones: novel iron chelators with enhanced pFe(3+) values.
    Journal of medicinal chemistry, 1999, Nov-18, Volume: 42, Issue:23

    Topics: Animals; Bile; Ferritins; Hydrogen-Ion Concentration; Iron; Iron Chelating Agents; Ligands; Potentiometry; Pyridines; Rats; Spectrophotometry, Ultraviolet; Structure-Activity Relationship

1999
Predicting blood-brain barrier permeation from three-dimensional molecular structure.
    Journal of medicinal chemistry, 2000, Jun-01, Volume: 43, Issue:11

    Topics: Blood-Brain Barrier; Databases, Factual; Models, Chemical; Molecular Conformation; Multivariate Analysis; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Basic 3-hydroxypyridin-4-ones: potential antimalarial agents.
    European journal of medicinal chemistry, 2008, Volume: 43, Issue:5

    Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Iron; Iron Chelating Agents; Iron Overload; Male; Parasitic Sensitivity Tests; Plasmodium falciparum; Pyridones; Rats; Rats, Wistar; Structure-Activity Relationship

2008
Synthesis, physical-chemical characterisation and biological evaluation of novel 2-amido-3-hydroxypyridin-4(1H)-ones: Iron chelators with the potential for treating Alzheimer's disease.
    Bioorganic & medicinal chemistry, 2011, Feb-01, Volume: 19, Issue:3

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Death; Cells, Cultured; Humans; Hydrophobic and Hydrophilic Interactions; Iron Chelating Agents; Mice; Molecular Probes; Neurodegenerative Diseases; Neuroprotective Agents; Oxidative Stress; Pyrones; Structure-Activity Relationship

2011
Studies of in vivo iron mobilization by chelators in the ferrocene-loaded rat.
    Biochemical pharmacology, 1992, Sep-25, Volume: 44, Issue:6

    Topics: Animals; Brain; Deferiprone; Deferoxamine; Disease Models, Animal; Ferrous Compounds; Heart; Hemochromatosis; Iron; Iron Chelating Agents; Liver; Male; Metallocenes; Organometallic Compounds; Pyridones; Rats; Rats, Wistar; Spleen; Subcellular Fractions

1992
A comparison of the iron-clearing properties of 1,2-dimethyl-3-hydroxypyrid-4-one, 1,2-diethyl-3-hydroxypyrid-4-one, and deferoxamine.
    Blood, 1992, Apr-01, Volume: 79, Issue:7

    Topics: Animals; Bile; Cebus; Deferiprone; Deferoxamine; Feces; Iron; Iron Chelating Agents; Kinetics; Male; Pyridones; Rats; Rats, Inbred Strains

1992
Origin and fate of iron mobilized by the 3-hydroxypyridin-4-one oral chelators: studies in hypertransfused rats by selective radioiron probes of reticuloendothelial and hepatocellular iron stores.
    Blood, 1992, Jan-01, Volume: 79, Issue:1

    Topics: Animals; Deferiprone; Feces; Female; Iron; Iron Chelating Agents; Iron Radioisotopes; Liver; Mononuclear Phagocyte System; Pyridones; Rats; Rats, Inbred Strains

1992
Influence of iron chelators, 1,2-dialkyl-3-hydroxypyridin-4-ones, on the lipid peroxidation and glutathione level in the liver of mice.
    Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1991, Volume: 14

    Topics: Animals; Cadmium; Carbon Tetrachloride; Deferiprone; Glutathione; In Vitro Techniques; Indium; Iron; Iron Chelating Agents; Lipid Peroxidation; Liver; Male; Malondialdehyde; Mice; Mice, Inbred ICR; Pyridones

1991
Inhibition of iron toxicity in rat and human hepatocyte cultures by the hydroxypyridin-4-ones CP20 and CP94.
    Journal of hepatology, 1995, Volume: 23, Issue:2

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cells, Cultured; Deferiprone; Extracellular Space; Humans; Iron; Iron Chelating Agents; Iron Radioisotopes; L-Lactate Dehydrogenase; Liver; Male; Malondialdehyde; Microscopy, Electron; Pyridones; Rats; Rats, Sprague-Dawley

1995
Effect of iron overload on the metabolism and urinary recovery of 3-hydroxypyridin-4-one chelating agents in the rat.
    Drug metabolism and disposition: the biological fate of chemicals, 1995, Volume: 23, Issue:3

    Topics: Animals; Deferiprone; Drug Overdose; Iron; Iron Chelating Agents; Male; Pyridones; Rats; Rats, Wistar

1995
Modulation by iron loading and chelation of the uptake of non-transferrin-bound iron by human liver cells.
    Biochimica et biophysica acta, 1995, Apr-13, Volume: 1243, Issue:3

    Topics: Biological Transport; Carcinoma, Hepatocellular; Cell Death; Deferiprone; Deferoxamine; Diffusion; Ferric Compounds; Humans; Iron; Iron Chelating Agents; Iron Radioisotopes; Kinetics; Liver; Liver Neoplasms; Nitrilotriacetic Acid; Pyridones; Quaternary Ammonium Compounds; Transferrin; Tumor Cells, Cultured

1995
Effect of iron chelation on the in-vitro growth of Leishmania promastigotes.
    The Journal of antimicrobial chemotherapy, 1995, Volume: 35, Issue:1

    Topics: Animals; Deferiprone; Deferoxamine; DNA; Electrophoresis, Polyacrylamide Gel; Immunoblotting; Iodine Radioisotopes; Iron Chelating Agents; Leishmania infantum; Leishmania major; Pyridones; Transferrin

1995
Ability of the orally effective iron chelators dimethyl- and diethyl-hydroxypyrid-4-one and of deferoxamine to restore sarcolemmal thiolic enzyme activity in iron-loaded heart cells.
    Blood, 1994, May-01, Volume: 83, Issue:9

    Topics: 5'-Nucleotidase; Administration, Oral; Animals; beta-N-Acetylhexosaminidases; Cells, Cultured; Deferiprone; Deferoxamine; Heart; Iron; Iron Chelating Agents; Lysosomes; Myocardium; Pyridones; Rats; Sarcolemma; Sodium-Potassium-Exchanging ATPase; Sulfhydryl Compounds

1994
Deferoxamine augments growth and pathogenicity of Rhizopus, while hydroxypyridinone chelators have no effect.
    Kidney international, 1994, Volume: 45, Issue:3

    Topics: Animals; Deferiprone; Deferoxamine; Guinea Pigs; Iron; Iron Chelating Agents; Male; Mucormycosis; Pyridones; Rhizopus; Transferrin

1994
The pharmacokinetics and blood-brain barrier permeation of the chelators 1,2 dimethly-, 1,2 diethyl-, and 1-[ethan-1'ol]-2-methyl-3-hydroxypyridin-4-one in the rat.
    Toxicology, 1996, Apr-30, Volume: 108, Issue:3

    Topics: Animals; Blood-Brain Barrier; Cerebral Ventricles; Chelating Agents; Deferiprone; Frontal Lobe; Iron Chelating Agents; Male; Microdialysis; Pyridones; Rats; Rats, Sprague-Dawley; Sodium Cyanide

1996
Aluminum speciation studies in biological fluids. Part 5. A quantitative investigation of A1(III) complex equilibria with desferrioxamine, 2,3-dihydroxybenzoic acid, Tiron, CP20 (L1), and CP94 under physiological conditions, and computer-aided assessment
    Journal of inorganic biochemistry, 1999, May-30, Volume: 75, Issue:1

    Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Aluminum; Animals; Body Fluids; Chelating Agents; Computer Simulation; Deferiprone; Deferoxamine; Humans; Hydroxybenzoates; Indicators and Reagents; Inflammation; Iron Chelating Agents; Ligands; Pyridones; Rabbits; Rats; Reproducibility of Results

1999