cp 96345 has been researched along with substance p in 260 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 215 (82.69) | 18.2507 |
| 2000's | 36 (13.85) | 29.6817 |
| 2010's | 9 (3.46) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bissantz, C; Bohnert, C; Hoffmann, T; Malherbe, P; Marcuz, A; Schnider, P | 1 |
| Dietrich, H; Maggi, CA; Saria, A; Zernig, G | 1 |
| Clingan, CA; Delay-Goyet, P; Franco-Cereceda, A; Gonsalves, SF; Lowe, JA; Lundberg, JM | 1 |
| Fong, TM; Strader, CD; Yu, H | 1 |
| Chrétien, L; Guillemette, G; Regoli, D; Tousignant, C | 1 |
| Hill, RG; Longmore, J | 1 |
| Carruette, A; Champion, A; Cottez, D; Garret, C; Goniot, P; Moussaoui, SM | 1 |
| Dalsgaard, CJ; Wiesenfeld-Hallin, Z; Xu, XJ | 2 |
| Barnes, PJ; Lei, YH; Rogers, DF | 1 |
| Appell, KC; Fragale, BJ; Loscig, J; Singh, S; Tomczuk, BE | 1 |
| Fujii, T; Kiyotoh, S; Maeda, Y; Morimoto, H; Murai, M; Nishikawa, M; Yamaoka, M | 1 |
| Gylfe, E; Sjödin, L | 1 |
| Donnerer, J; Lembeck, F; Nagahisa, A; Tsuchiya, M | 1 |
| Bordner, J; Bryce, DK; Drozda, SE; Jackson, ER; Longo, KP; Lowe, JA; McLean, S; Morrone, J; Snider, RM; Zorn, SH | 2 |
| Astolfi, M; Maggi, CA; Patacchini, R; Rovero, P; Santicioli, P; Viti, G | 1 |
| Griesbacher, T; Legat, FJ; Lembeck, F | 1 |
| Donnerer, J; Griesbacher, T; Legat, FJ; Lembeck, F | 1 |
| Donnerer, J; Lembeck, F; Stark, U; Tritthart, HA | 1 |
| Alouan, LA; Armour, CL; Badgery-Parker, T; Black, JL; Burcher, E; Diment, LM; Johnson, PR | 1 |
| Heym, J; McLean, S; Schmidt, AW | 1 |
| Constantine, JW; Desai, MC; Drozda, SE; Lebel, WS; Longo, KP; Lowe, JA; Snider, RM; Spencer, RW; Vinick, FJ; Woody, HA | 1 |
| Bryce, DK; Ganong, AH; Heym, J; Lowe, JA; McLean, S; Pratt, KG; Reynolds, LS; Seeger, TF; Siok, CJ | 1 |
| Folkers, K; Håkanson, R; Wang, ZY | 1 |
| Bruns, RF; Gitter, BD; Howbert, JJ; Mason, NR; Nixon, JA; Waters, DC | 1 |
| Drozda, SE; Leeman, SE; Longo, KP; Lowe, JA; Snider, RM | 1 |
| Giuliani, S; Lecci, A; Maggi, CA; Patacchini, R; Viti, G | 1 |
| Yaksh, TL; Yamamoto, T | 1 |
| De Koninck, Y; Henry, JL | 1 |
| Constantine, JW; Lebel, WS; Woody, HA | 1 |
| Henry, JL; Radhakrishnan, V | 3 |
| Broccardo, M; Improta, G; Severini, C | 1 |
| Akaike, N; Kakehata, S; Takasaka, T; Yamamoto, T | 1 |
| Cezaretti, ML; Gavras, H; Gavras, I; Ginoza, M; Kohlmann, O; Leeman, SE; Ramos, OL; Ribeiro, AB; Tavares, A; Zanella, MT | 1 |
| Longmore, J; Razzaque, Z | 1 |
| Kuraishi, Y; Okano, K; Satoh, M | 4 |
| Shaikh, MB; Siegel, A; Steinberg, A | 1 |
| Beaujouan, JC; Glowinski, J; Petitet, F; Saffroy, M; Torrens, Y | 1 |
| Gether, U; Schwartz, TW; Zoffmann, S | 1 |
| Kamikawa, Y; Shimo, Y | 1 |
| DeRose, V; Rennard, SI; Robbins, RA; Rubinstein, I; Snider, RM; Spurzem, JR; Thiele, GM | 1 |
| Castagliuolo, I; Jaffer, A; LaMont, JT; Leeman, SE; O'Keane, JC; Pothoulakis, C; Snider, RM | 1 |
| Gerard, NP; Gether, U; Jensen, CJ; Schwartz, TW | 1 |
| Longmore, J; Main, MJ; Razzaque, Z; Seabrook, GR | 1 |
| Gibb, JW; Gygi, SP; Hanson, GR; Johnson, M | 1 |
| Akkermans, LM; Briejer, MR; Lefebvre, RA; Meulemans, AL; Schuurkes, JA | 1 |
| Boccio, D; Carruette, A; Garret, C; Montier, F; Moussaoui, S | 1 |
| Bannon, MJ; Kapatos, G; Whitty, CJ | 1 |
| Mak, IT; Phillips, TM; Weglicki, WB | 1 |
| Joos, GF; Kips, JC; Pauwels, RA | 1 |
| Dimlich, RV; Gruenstein, E; Medrano, S | 1 |
| Boni, P; Evangelista, S; Maggi, CA | 1 |
| Goso, C; Manzini, S; Potier, E; Szallasi, A | 1 |
| Buéno, L; Julia, V; Morteau, O | 1 |
| Hill, RG; Longmore, J; Razzaque, Z; Shaw, D | 1 |
| Couture, R; Picard, P; Prat, A | 1 |
| De Sanctis, GT; Green, FH; Jiang, X; King, M; Remmers, JE | 1 |
| Edwall, L; Kerezoudis, NP; Olgart, L | 2 |
| Corsi, M; Gaviraghi, G; Oliosi, B; Palea, S; Pietra, C; Sugg, E; Trist, DG; Van Amsterdam, FT | 1 |
| Brugger, F; Evans, RH; Lepre, M; Olpe, HR | 2 |
| Vanner, S | 1 |
| De Koninck, Y; Henry, JL; Salter, MW | 1 |
| Bertrand, C; Chan, B; Geppetti, P; Nadel, JA; Ricciardolo, FL; Yamawaki, I | 1 |
| Katsumata, K; Kisara, K; Manome, Y; Ohba, M; Sakurada, S; Sakurada, T; Tan-No, K | 1 |
| Gomi, Y; Mizuno, K; Suzuki, N | 1 |
| Barrett, KE | 1 |
| Bollinger, RR; Maggio, JE; Mantyh, CR; Mantyh, PW; Pappas, TN; Vigna, SR | 1 |
| Bowery, NG; Malcangio, M | 1 |
| Delay-Goyet, P; Rinder, J; Stjärne, P | 1 |
| Crankshaw, CL; Krause, JE; Raddatz, R; Snider, RM | 1 |
| Elling, CE; Nielsen, SM; Schwartz, TW | 2 |
| Barthó, L; Lefebvre, R | 1 |
| Lefebvre, RA; Smits, GJ | 1 |
| Freudenberger, U; Neugebauer, V; Schaible, HG; Weiretter, F | 1 |
| Furness, LE; Maier, SF; Watkins, LR; Wiertelak, EP | 1 |
| Colasurdo, GN; Graves, JP; Larsen, GL; Loader, JE | 1 |
| Cascieri, MA; Fong, TM; Hardwicke, S; Lewis, RT; MacIntyre, DE; MacLeod, AM; Merchant, KJ; Metzger, JM; Sadowski, S; Shepheard, S | 1 |
| Ballati, L; Boni, P; Evangelista, S | 1 |
| Gether, U; Lowe, JA; Schwartz, TW | 1 |
| Nourshargh, S; Walsh, DT; Weg, VB; Williams, TJ | 1 |
| Killingsworth, CR; Shore, SA | 1 |
| Benrath, J; Eschenfelder, C; Gillardon, F; Zimmerman, M | 1 |
| Benrath, J; Eschenfelder, CC; Gillardon, F; Zimmermann, M | 1 |
| Garces, YI; Minshall, RD; Rabito, SF; Sagen, J | 1 |
| Ganea, D; Gascón, P; Rameshwar, P | 1 |
| Barr, AJ; Watson, SP | 1 |
| Krause, JE; Lowe, JA; Sachais, BS; Snider, RM | 1 |
| Barnes, PJ; Chung, KF; Sakamoto, T | 1 |
| Couture, R; Pham, TM | 1 |
| Claing, A; D'Orléans-Juste, P; Jukic, D; Nicolau, M; Regoli, D; Rouissi, N | 1 |
| Dray, A; Maggi, CA; Nagy, I; Urban, L; Woolf, CJ | 1 |
| Coderre, TJ; Henry, JL; Radhakrishnan, V; Yashpal, K | 1 |
| Ferrell, WR; Lam, FY | 1 |
| Mutabagani, K; Tamura, K; Wood, JD | 1 |
| Boucher, S; Couture, R; Gitter, BD; Howbert, JJ; Picard, P; Regoli, D | 1 |
| Saria, A; Troger, J; Zernig, G | 2 |
| Advenier, C; Emonds-Alt, X; Qian, Y | 1 |
| Greeno, EW; Mantyh, P; Moldow, CF; Vercellotti, GM | 1 |
| Del Rosario, RB; Drozda, SE; Gildersleeve, DL; Lowe, JA; Mangner, TJ; Shreve, PD; Snider, RM; Weiland, DM | 1 |
| Katsumata, K; Kisara, K; Sakurada, S; Sakurada, T; Tan-No, K; Yogo, H | 1 |
| Bueno, L; Fargeas, MJ; Fioramonti, J | 1 |
| Giuliani, S; Maggi, CA; Meini, S; Patacchini, R | 1 |
| Iwata, T; Kamiya, H; Matsumoto, H; Ohno, M; Saito, R; Shimohigashi, Y; Takano, Y | 1 |
| Luo, L; Wiesenfeld-Hallin, Z | 1 |
| Blum, AM; Cook, G; Elliott, D; Mathew, RC; Metwali, A; Weinstock, JV | 1 |
| Brelière, JC; Emonds-Alt, X; Gether, U; Lowe, JA; Nakanishi, S; Schwartz, TW; Snider, RM; Yokota, Y | 1 |
| Giuliani, S; Lecci, A; Lippe, IT; Maggi, CA; Santicioli, P | 1 |
| Anding, P; Gao, XP; Lowe, J; Rennard, SI; Robbins, RA; Rubinstein, I; Snider, RM | 1 |
| Kato, N; Yoshimura, H | 1 |
| Bertrand, C; Bunnett, NW; Debas, HT; Geppetti, P; Huber, O; Nadel, JA; Pellegrini, CA | 1 |
| Bertrand, C; Geppetti, P; Nadel, JA; Yamawaki, I | 1 |
| Henry, JL | 1 |
| Baker, J; Bertrand, C; Geppetti, P; Nadel, JA; Yamawaki, I | 1 |
| Ihara, C; Imura, H; Ishikawa, Y; Kasai, K; Mizuta, H; Mori, K; Shimatsu, A | 1 |
| Adachi, T; Sato, A; Sato, Y | 1 |
| Cao, H; Lowe, JA; Prabhakar, NR; Snider, RM | 1 |
| Hosoki, R; Otsuka, M; Yanagisawa, M | 1 |
| Jukic, D; Nguyen, QT; Regoli, D; Rouissi, N | 1 |
| Honda, K; Kamiya, H; Nakayama, Y; Saigo, A; Saito, R; Takano, Y | 1 |
| Bock, MD; Clerc, F; Fardin, V; Flamand, O; Foucault, F; Garret, C; Jolly, A | 1 |
| Delay-Goyet, P; Lundberg, JM; Rinder, J; Satoh, H; Stjärne, P | 1 |
| Cavero, I; Floch, A; Massa, N; Thiry, C | 1 |
| Giachetti, A; Giuliani, S; Maggi, CA; Patacchini, R | 1 |
| Couture, R; Culman, J; Picard, P; Prat, A; Regoli, D; Tschöpe, C; Unger, T | 1 |
| Chahl, LA; Johnston, PA | 1 |
| Chahl, LA; Kavanagh, CA | 1 |
| Bartho, L; Giuliani, S; Maggi, CA; Santicioli, P | 1 |
| Birder, LA; Fukuoka, H; Kawatani, M; Matsumoto, G; Misaki, A; Suzuki, S; Yoshiyama, M | 1 |
| Dray, A; Maggi, CA; Nagy, I; Urban, L | 1 |
| Boucher, S; Couture, R; Picard, P; Regoli, D | 1 |
| Berge, OG; Ståhlberg, M | 1 |
| Asai, R; Kanai, Y; Murase, A; Nagahisa, A; Nakagaki, T; Shieh, TC; Taniguchi, K; Tsuchiya-Nakagaki, M | 1 |
| Nagy, J; Pethö, G; Szolcsányi, J | 1 |
| Hess, HJ; Kanai, Y; Lowe, JA; Nagahisa, A; Suga, O; Taniguchi, K; Tsuchiya, M | 1 |
| Bertrand, C; Geppetti, P; Graf, PD; Nadel, JA | 1 |
| Gradin, K; Persson, B | 1 |
| Boyle, SJ; Guard, S; McKnight, AT; Tang, KW; Watling, KJ; Woodruff, GN | 1 |
| Baugh, LE; Farrell, AM; Kudlacz, EM; Logan, DE; Shatzer, SA | 1 |
| Doble, A; Heuillet, E; Hubert, JP; Laville, M; Le Guern, S; Pradier, L | 1 |
| Hayashi, H; Toda, T | 1 |
| Mizuguchi, T; Shimoyama, N; Yamamoto, T | 1 |
| Bisgard, GE; Hedrick, MS; Keith, IM; Pizarro, J; Ryan, ML; Xue, DH | 1 |
| Bakker, WH; Breeman, WA; Hazenberg, MP; Koper, JW; Krenning, EP; Kwekkeboom, DJ; Lamberts, SW; Setyono-Han, B; van der Pluijm, ME; VanHagen, MP; Visser, TJ; Visser-Wisselaar, HA | 1 |
| Doerfler, DL; Sailstad, DM; Selgrade, M; Veronesi, B | 1 |
| Boyd, ND; Hsu, P; Krause, JE; Leeman, SE; Li, H; Sachais, BS | 1 |
| Gao, GC; Wei, ET | 1 |
| Gascón, P; Rameshwar, P | 1 |
| Jafri, MS; Weinreich, D | 1 |
| Bonham, AC; Joad, JP; Kappagoda, CT; Kott, KS; Ravi, K | 1 |
| Chapman, RW; Danko, G; del Prado, M; Hey, JA | 1 |
| Han, Y; Shaikh, MB; Siegel, A | 1 |
| Amerini, S; Ledda, F; Maggi, CA; Parenti, A; Ziche, M | 1 |
| Bian, JT | 1 |
| Back, SM; Hua, XY; Tam, EK | 1 |
| Mitrovic, I; Napier, TC | 2 |
| Sawada, T; Takagi, J; Yonehara, N | 1 |
| Henry, JL; Hui-Chan, CW; Yashpal, K | 1 |
| Burcher, E; Geraghty, DP; Lavielle, S; Strigas, J; Zeng, XP | 1 |
| Traub, RJ | 1 |
| Luo, W; Sharif, M; Sharif, TR | 1 |
| Bonham, AC; Joad, JP; Kott, KS | 1 |
| Amerini, S; Ledda, F; Maggi, CA; Parenti, A; Zawieja, D; Ziche, M | 1 |
| Galligan, JJ; Yunker, AM | 1 |
| Advenier, C; Bellamy, JF; Emonds-Alt, X; Molimard, M; Naline, E; Regoli, D | 1 |
| Chrétien, L; Gobeil, F; Jukic, D; Nguyen, QT; Nguyen-Le, XK; Regoli, D | 1 |
| Boyer, V; Harf, A; Jarreau, PH; Macquin-Mavier, I | 1 |
| Spannhake, EW; Undem, BJ; Yu, XY | 1 |
| Bost, KL; Kincy-Cain, T | 1 |
| Cesaretti, ML; Gavras, H; Gavras, I; Ginoza, M; Kohlmann, O; Leeman, SE; Ramos, OL; Ribeiro, AB; Tavares, A; Zanella, MT | 1 |
| Castagliuolo, I; Keates, AC; Kelly, CP; Leeman, SE; Nikulasson, S; Pothoulakis, C; Qiu, B | 1 |
| Fox, AJ; Naeem, S; Patel, IA; Urbán, L; Walpole, C | 1 |
| Barron, KW; Chandler, MJ; Croom, JE; Foreman, RD | 1 |
| Chirtel, SJ; Field, RB; Redman, RS | 1 |
| Taché, Y; Yang, H | 1 |
| Kitto, KF; Larson, AA; Velázquez, RA | 1 |
| Farley, DM; Kopp, UC; Smith, LA | 1 |
| Chassaing, G; Chollet, A; Drozda, SE; Lowe, JA; Schwartz, TW; Turcatti, G; Zoffmann, S | 1 |
| Gustafsson, LE; Olgart, C; Wiklund, NP | 1 |
| Boudon, A; Fauchère, JL; Jacoby, E; Kucharczyk, N; Michel, A | 1 |
| Hawcock, AB; Lundstrom, K; Naylor, A; Thomas, P; Vargas, A; Ward, P | 1 |
| Holst, JJ; Rasmussen, TN; Schmidt, PT | 1 |
| Austin-Ritchie, T; Baker, S; Carraway, RE; Hollins, C; Luber-Narod, J; Malhotra, RK; Menon, M | 1 |
| Bosch, SM; Diz, DI; Ferrario, C; Ganten, D; Westwood, B | 1 |
| Kisara, K; Sakurada, T; Tan-No, K | 1 |
| Gao, XP | 1 |
| Anthes, J; Billah, M; Brown, JE; Cheewatrakoolpong, B; Egan, RW; Greenfeder, S; Murgolo, NJ | 1 |
| Belmonte, KE; Costello, RW; Fryer, AD; Jacoby, DB | 1 |
| Castagliuolo, I; Hoffman, BJ; Leeman, SE; Li, H; Mezey, E; Pothoulakis, C; Wang, CC | 1 |
| Fan, DS; Liu, T; Yang, PC; Zhang, TY | 1 |
| Beusen, DD; Marshall, GR; Shands, EF; Takeuchi, Y | 1 |
| Inoue, M; Nakayamada, H; Tokuyama, S; Ueda, H | 1 |
| Burcher, E; Nail, BS; Yuan, L | 1 |
| Broussard, DL; Feng, HS; Ouyang, A | 1 |
| Bauman, NM; Jaffe, DM; Luschei, ES; Sandler, AD; Wang, D | 1 |
| Freire-Maia, L; Leite, R; Matos, IM; Teixeira, MM | 1 |
| Cuello, AC; Henry, JL; Julien, JP; McLeod, AL; Ribeiro-Da-Silva, A; Ritchie, J | 1 |
| Mori, M; Tsushima, H | 1 |
| Chen, CF; Chen, LW; Lai, YL | 1 |
| Kohno, S; Nabe, T; Ogawa, K; Yamamura, H | 1 |
| Ando, R; Inoue, M; Kisara, K; Sakurada, C; Sakurada, T; Tan-No, K; Watanabe, C | 1 |
| Inoue, M; Katsuyama, S; Kisara, K; Sakurada, C; Sakurada, S; Sakurada, T; Sasaki, J; Tan-No, K; Ueda, H | 1 |
| Goto, F; Ishizaki, K; Karasawa, S; Nara, T; Obata, H; Sasaki, M | 1 |
| Kataoka, K; Mori, T; Nakamura, Y; Ogata, T; Okumura, H; Shibata, T | 1 |
| Dellamano, LM; Iwamoto, GA; Kozlowski, GP; Rybicki, KJ; Swiatkowski, K; Vissing, J | 1 |
| Gascón, P; Hameed, M; Joshi, DD; Maloof, PB; Mosenthal, A; Qian, J; Rameshwar, P; Singh, D | 1 |
| Kou, YR; Kumar, GK; Overholt, JL; Prabhakar, NR | 1 |
| Kamiki, T; Kohno, S; Nabe, T; Tanpo, T; Yasui, K | 1 |
| Bonham, AC; Joad, JP; Mutoh, T | 1 |
| Bunnett, NW; Grady, EF; Hutter, MM; Kim, EH; Kirkwood, KS; Maa, J; Yoshimi, SK | 1 |
| Compernolle, F; De Wit, T; Hoornaert, GJ; Van Emelen, K | 1 |
| Connor, P; Farthing, MJ; Turvill, JL | 1 |
| Becker, JM; Beer, E; Leeman, S; Materne, O; McClung, J; Moore, F; O'Brien, M; Shebani, K; Shofer, S; Stucchi, AF | 1 |
| Farber, EM; Raychaudhuri, SP | 1 |
| Collman, RG; Douglas, SD; Ho, WZ; Lai, JP; Yi, Y; Zhan, GX | 1 |
| Cassone, MC; Collino, M; Dianzani, C; Fantozzi, R; Ferrara, C; Lombardi, G | 1 |
| Liu, T; Wang, B; Yang, P | 1 |
| Blier, P; Haddjeri, N | 1 |
| Allescher, HD; Hahn, A; Storr, M | 1 |
| Willis, WD | 1 |
| Douglas, SD; Ho, WZ; Lai, JP; Song, L; Wang, X; Yang, JH | 1 |
| Itoh, M; Iwata, F; Kao, J; Leung, FW; Leung, JW; Seno, K | 1 |
| Böckmann, S | 1 |
| Douglas, SD; Guo, CJ; Ho, WZ; Lai, JP; Luo, HM | 1 |
| Chien, CT; Hsu, SM; Lai, MK; Lin, TB; Yu, HJ | 1 |
| Boudah, A; Jasmin, L; Ohara, PT | 1 |
| Elliott, J; Katz, LM; Marr, CM | 1 |
| Bannerman, P; Commons, KG; Douglas, SD; Ho, C; Ho, W; Lai, J; Pleasure, DE; Wang, X; Williams, M | 1 |
| Douglas, SD; Gao, Z; Grinspan, J; Guo, CJ; Ho, WZ; Lai, JP; Riedel, E; Wolf, BA | 1 |
| Bhatia, M; Lau, HY; Wong, FL | 1 |
| Bhatia, M; Lau, HY | 2 |
| Bhatia, M; Moore, PK; Ng, SW; Zhang, H; Zhi, L | 1 |
| Bittner, A; Brueck, W; Gronen, F; Hemmer, B; Nessler, S; Schlegel, K; Sommer, N; Stadelmann, C | 1 |
| Douglas, SD; Ho, WZ; Peng, JS; Wan, Q; Wang, X; Zhou, DJ | 1 |
| Cahill, CM; Henry, JL; Landau, AM; Ribeiro-da-Silva, A; St Louis, M; Yashpal, K | 1 |
| Bhatia, M; Ramnath, RD; Sun, J | 1 |
| Benton, T; Douglas, SD; Dubé, B; Evans, DL; Gettes, DR; Lai, JP; Lynch, KG; Metzger, D; Tustin, NB | 1 |
| Adhikari, S; Bhatia, M; Ramnath, RD; Sun, J; Zhi, L | 1 |
| Chang, LC; Chen, WC; Li, PC; Lin, SC | 1 |
| Li, YS; Miyano, K; Nakata, Y; Tang, HB | 1 |
| Ghazanfari, T; Yaraee, R | 1 |
| Cox, RA; Deyo, DJ; Hawkins, HK; Herndon, DN; Jacob, RK; Jacob, S; Traber, DL | 1 |
| Liu, L; Pasricha, PJ; Shenoy, M | 1 |
| Hisaoka-Nakashima, K; Izumi, H; Morioka, N; Nakamura, Y; Nakata, Y; Shimizu, T | 1 |
| Du, JQ; Kong, LH; Liu, XH; Sun, N; Xu, Y; Zhu, JX | 1 |
| Li, C; Micci, MA; Murthy, KS; Pasricha, PJ | 1 |
| Gerashchenko, D; Karpova, SA; Yang, X; Zielinski, MR | 1 |
| DU, J; Han, M; Liu, X | 1 |
| Alevizos, M; Conti, P; Karagkouni, A; Leeman, SE; Norwitz, E; Taracanova, A; Theoharides, TC; Weng, Z | 1 |
5 review(s) available for cp 96345 and substance p
| Article | Year |
|---|---|
Tachykinin non-peptide antagonists: binding domain and molecular mode of action.
Topics: Animals; Benzamides; Binding Sites; Binding, Competitive; Biphenyl Compounds; GTP-Binding Proteins; Humans; Kinetics; Mutagenesis, Site-Directed; Neurokinin A; Piperidines; Point Mutation; Protein Structure, Secondary; Receptors, Tachykinin; Recombinant Fusion Proteins; Substance P; Tachykinins | 1995 |
Participation of substance P in spinal physiological responses to peripheral aversive stimulation.
Topics: Animals; Biphenyl Compounds; Hypnotics and Sedatives; Neurokinin A; Neurons; Pain; Receptors, Neurokinin-2; Reflex; Spinal Cord; Substance P | 1993 |
Discovery of CP-96,345 and its characterization in disease models involving substance P.
Topics: Analgesics; Animals; Asthma; Binding, Competitive; Biphenyl Compounds; Disease Models, Animal; Inflammation; Pain; Receptors, Neurokinin-2; Substance P | 1993 |
[Pharmacological profile of sendide, a tachykinin NK-1 receptor antagonist].
Topics: Analgesics; Animals; Biphenyl Compounds; Mice; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Pyrrolidonecarboxylic Acid; Spinal Cord; Substance P | 1997 |
Role of neurotransmitters in sensitization of pain responses.
Topics: Animals; Biphenyl Compounds; Capsaicin; Excitatory Amino Acid Agonists; Haplorhini; Hot Temperature; Humans; Hyperalgesia; Injections, Intradermal; Long-Term Potentiation; Mechanoreceptors; Microdialysis; Models, Animal; Models, Neurological; Neurons, Afferent; Neurotransmitter Agents; Nociceptors; Pain; Phosphorylation; Posterior Horn Cells; Protein Processing, Post-Translational; Rats; Receptors, Drug; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Signal Transduction; Spinothalamic Tracts; Substance P | 2001 |
1 trial(s) available for cp 96345 and substance p
| Article | Year |
|---|---|
Selective serotonin reuptake inhibitor and substance P antagonist enhancement of natural killer cell innate immunity in human immunodeficiency virus/acquired immunodeficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Adult; Biphenyl Compounds; Citalopram; Depressive Disorder; Depressive Disorder, Major; Female; Glucocorticoids; HIV Seropositivity; Hormone Antagonists; Humans; Immunity, Innate; Killer Cells, Natural; Lymphocyte Count; Middle Aged; Mifepristone; Personality Inventory; Selective Serotonin Reuptake Inhibitors; Substance P; T-Lymphocytes, Cytotoxic; Viral Load | 2008 |
254 other study(ies) available for cp 96345 and substance p
| Article | Year |
|---|---|
Identification of a crucial amino acid in the helix position 6.51 of human tachykinin neurokinin 1 and 3 receptors contributing to the insurmountable mode of antagonism by dual NK₁/NK₃ antagonists.
Topics: Amino Acids; Aminopyridines; Benzeneacetamides; HEK293 Cells; Humans; Inositol Phosphates; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Neurokinin-1 Receptor Antagonists; Protein Structure, Secondary; Radioligand Assay; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Stereoisomerism | 2012 |
The substance P (NK1) receptor antagonist (+/-)-CP-96,345 causes sedation and motor impairment in Swiss albino mice in the black-and-white box behavioral paradigm.
Topics: Animals; Anxiety; Biphenyl Compounds; Depression, Chemical; Exploratory Behavior; Hypnotics and Sedatives; Male; Mice; Motor Activity; Naloxone; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Receptors, Opioid; Rotation; Substance P | 1992 |
CP-96,345 antagonism of NK1 receptors and smoke-induced protein extravasation in relation to its cardiovascular effects.
Topics: Animals; Biphenyl Compounds; Blood Proteins; Extravasation of Diagnostic and Therapeutic Materials; Guinea Pigs; Hemodynamics; Injections, Intravenous; Male; Muscle Contraction; Muscle, Smooth, Vascular; Myocardial Contraction; Nicotiana; Plants, Toxic; Rats; Rats, Sprague-Dawley; Receptors, Neurotransmitter; Receptors, Tachykinin; Smoke; Substance P; Swine; Trachea | 1992 |
Molecular basis for the species selectivity of the neurokinin-1 receptor antagonists CP-96,345 and RP67580.
Topics: Amino Acid Sequence; Animals; Binding Sites; Biphenyl Compounds; Cloning, Molecular; Humans; Indoles; Isoindoles; Kinetics; Mutagenesis, Site-Directed; Neurokinin A; Protein Conformation; Rats; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Recombinant Fusion Proteins; Recombinant Proteins; Substance P | 1992 |
Characterization of NK-1 receptors in guinea pig and rat brain membranes with NK-1 peptides and a non-peptide antagonist.
Topics: Amino Acid Sequence; Animals; Biphenyl Compounds; Brain; Guinea Pigs; Membranes; Molecular Sequence Data; Neurokinin A; Neurokinin B; Rats; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P | 1992 |
Characterisation of NK receptors in guinea-pig urinary bladder smooth muscle: use of selective antagonists.
Topics: Animals; Biphenyl Compounds; Guinea Pigs; Hypnotics and Sedatives; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Urinary Bladder | 1992 |
Comparison in different tissue preparations of the in vitro pharmacological profile of RP 67580, a new non-peptide substance P antagonist.
Topics: Animals; Biphenyl Compounds; Female; Guinea Pigs; In Vitro Techniques; Indoles; Isoindoles; Male; Molecular Structure; Muscle, Smooth; Muscle, Smooth, Vascular; Organ Specificity; Rabbits; Rats; Rats, Sprague-Dawley; Stereoisomerism; Substance P | 1992 |
Spinal substance P and N-methyl-D-aspartate receptors are coactivated in the induction of central sensitization of the nociceptive flexor reflex.
Topics: Animals; Biphenyl Compounds; Conditioning, Psychological; Dizocilpine Maleate; Electromyography; Evoked Potentials; Female; Hindlimb; Hypnotics and Sedatives; Injections, Spinal; Male; Nerve Fibers; Neurons, Afferent; Nociceptors; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Reflex; Spinal Cord; Substance P | 1992 |
Inhibition of neurogenic plasma exudation in guinea-pig airways by CP-96,345, a new non-peptide NK1 receptor antagonist.
Topics: Animals; Biphenyl Compounds; Capsaicin; Electric Stimulation; Evans Blue; Exudates and Transudates; Guinea Pigs; Male; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P; Vagus Nerve | 1992 |
Antagonists that demonstrate species differences in neurokinin-1 receptors.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Biphenyl Compounds; Cell Line; Guinea Pigs; Humans; Molecular Sequence Data; Neurokinin A; Rats; Rats, Inbred Strains; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Species Specificity; Structure-Activity Relationship; Substance P | 1992 |
FK 224, a novel cyclopeptide substance P antagonist with NK1 and NK2 receptor selectivity.
Topics: Animals; Binding, Competitive; Biphenyl Compounds; Cell Membrane; Cerebral Cortex; Guinea Pigs; Lung; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptides, Cyclic; Rats; Rats, Inbred Strains; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P | 1992 |
A selective and potent antagonist of substance P receptors on pancreatic acinar cells.
Topics: Animals; Biphenyl Compounds; Calcium; Cells, Cultured; Guinea Pigs; Pancreas; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P | 1992 |
The non-peptide tachykinin antagonist, CP-96,345, is a potent inhibitor of neurogenic inflammation.
Topics: Animals; Biphenyl Compounds; Blood Pressure; Blood Proteins; Evans Blue; Female; Inflammation; Mustard Plant; Plant Extracts; Plant Oils; Pregnancy; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P; Vasoactive Intestinal Peptide | 1992 |
The discovery of (2S,3S)-cis-2-(diphenylmethyl)-N-[(2-methoxyphenyl)methyl]-1- azabicyclo[2.2.2]-octan-3-amine as a novel, nonpeptide substance P antagonisst.
Topics: Amino Acid Sequence; Animals; Biphenyl Compounds; Capsaicin; Cells, Cultured; Cerebral Cortex; Cricetinae; Extravasation of Diagnostic and Therapeutic Materials; Guinea Pigs; Humans; Male; Molecular Sequence Data; Rats; Rats, Inbred Strains; Salivation; Structure-Activity Relationship; Substance P | 1992 |
Activity of peptide and non-peptide antagonists at peripheral NK1 receptors.
Topics: Amino Acid Sequence; Animals; Biphenyl Compounds; Cricetinae; Guinea Pigs; In Vitro Techniques; Male; Mesocricetus; Molecular Sequence Data; Muscle, Smooth; Muscle, Smooth, Vascular; Oligopeptides; Peptides; Peptides, Cyclic; Rabbits; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P | 1992 |
CP-96,345, a non-peptide antagonist of substance P: I. Effects on the actions mediated by substance P and related tachykinins on the guinea-pig ileum and rabbit jejunum.
Topics: Animals; Biphenyl Compounds; Capsaicin; Electric Stimulation; Guinea Pigs; Hexamethonium Compounds; Histamine; Ileum; In Vitro Techniques; Jejunum; Muscle Contraction; Muscle, Smooth; Parasympathetic Nervous System; Peristalsis; Rabbits; Stereoisomerism; Substance P; Tachykinins | 1992 |
CP-96,345, a non-peptide antagonist of substance P: II. Actions on substance P-induced hypotension and bronchoconstriction, and on depressor reflexes in mammals.
Topics: Animals; Biphenyl Compounds; Blood Pressure; Bronchoconstriction; Female; Guinea Pigs; In Vitro Techniques; Male; Rabbits; Rats; Rats, Sprague-Dawley; Reflex; Stereoisomerism; Substance P; Tachykinins | 1992 |
CP-96,345, a non-peptide antagonist of substance P. III. Cardiovascular effects in mammals unrelated to actions on substance P receptors.
Topics: Anesthesia; Animals; Biphenyl Compounds; Blood Pressure; Decerebrate State; Electrocardiography; Electrophysiology; Guinea Pigs; Heart; Heart Rate; Hemodynamics; In Vitro Techniques; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P | 1992 |
Tachykinin receptors in rabbit airways--characterization by functional, autoradiographic and binding studies.
Topics: Amino Acid Sequence; Animals; Autoradiography; Binding Sites; Biphenyl Compounds; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Peptides, Cyclic; Rabbits; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Tachykinins; Trachea | 1992 |
Intrathecal CP-96,345 blocks reflex facilitation induced in rats by substance P and C-fiber-conditioning stimulation.
Topics: Analysis of Variance; Animals; Behavior, Animal; Biphenyl Compounds; Electric Stimulation; Injections, Spinal; Nerve Fibers; Neurokinin A; Rats; Rats, Sprague-Dawley; Reflex; Spinal Cord; Substance P; Sural Nerve | 1992 |
The substance P receptor antagonist CP-96,345 interacts with Ca2+ channels.
Topics: Animals; Binding, Competitive; Biphenyl Compounds; Brain; Calcium Channels; Diltiazem; Drug Interactions; Guinea Pigs; Heart; Nitrendipine; Radioligand Assay; Rats; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P; Tritium; Verapamil | 1992 |
A potent nonpeptide antagonist of the substance P (NK1) receptor.
Topics: Animals; Binding, Competitive; Biphenyl Compounds; Carotid Arteries; Cattle; Dogs; Molecular Structure; Muscle Contraction; Muscle Relaxation; Rabbits; Rats; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Salivation; Stereoisomerism; Substance P | 1991 |
Activity and distribution of binding sites in brain of a nonpeptide substance P (NK1) receptor antagonist.
Topics: Action Potentials; Animals; Autoradiography; Binding Sites; Binding, Competitive; Biphenyl Compounds; Brain; Corpus Striatum; Guinea Pigs; Hydrogen-Ion Concentration; Male; Radionuclide Imaging; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Receptors, Tachykinin; Spectrophotometry; Substance P; Tachykinins | 1991 |
Comparison of spantide II and CP-96,345 for blockade of tachykinin-evoked contractions of smooth muscle.
Topics: Analgesics; Animals; Biphenyl Compounds; Female; In Vitro Techniques; Iris; Male; Muscle Contraction; Muscle, Smooth; Rabbits; Substance P; Tachykinins | 1991 |
Species differences in affinities of non-peptide antagonists for substance P receptors.
Topics: Animals; Binding, Competitive; Biphenyl Compounds; Cattle; Chickens; Guinea Pigs; Humans; Mice; Quinuclidines; Rabbits; Rats; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Species Specificity; Substance P | 1991 |
Effect of CP-96,345, a nonpeptide substance P receptor antagonist, on salivation in rats.
Topics: Animals; Binding, Competitive; Biphenyl Compounds; Cell Membrane; Dose-Response Relationship, Drug; Kinetics; Male; Parotid Gland; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Saliva; Submandibular Gland; Substance P | 1991 |
Role of NK1 tachykinin receptors in thermonociception: effect of (+/-)-CP 96,345, a non-peptide substance P antagonist, on the hot plate test in mice.
Topics: Animals; Behavior, Animal; Biphenyl Compounds; Bombesin; Hot Temperature; Injections, Spinal; Male; Mice; Nociceptors; Reaction Time; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P | 1991 |
Stereospecific effects of a nonpeptidic NK1 selective antagonist, CP-96,345: antinociception in the absence of motor dysfunction.
Topics: Analgesics; Animals; Biphenyl Compounds; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Injections, Spinal; Kinetics; Motor Activity; Pain Measurement; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Spinal Cord; Stereoisomerism; Substance P | 1991 |
Substance P-mediated slow excitatory postsynaptic potential elicited in dorsal horn neurons in vivo by noxious stimulation.
Topics: Animals; Biphenyl Compounds; Cats; Evoked Potentials; Ganglia, Spinal; Neurons; Nociceptors; Pain; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Spinal Cord; Substance P; Synapses; Time Factors; Touch | 1991 |
Inhibition of tachykinin-induced hypotension in dogs by CP-96,345, a selective blocker of NK-1 receptors.
Topics: Animals; Biphenyl Compounds; Blood Pressure; Decerebrate State; Dogs; Dose-Response Relationship, Drug; Female; Heart Rate; In Vitro Techniques; Isoproterenol; Male; Neurokinin A; Peptide Fragments; Receptors, Neurotransmitter; Receptors, Tachykinin; Stereoisomerism; Substance P; Tachykinins | 1991 |
Novel substance P antagonist, CP-96,345, blocks responses of cat spinal dorsal horn neurons to noxious cutaneous stimulation and to substance P.
Topics: Animals; Biphenyl Compounds; Cats; Evoked Potentials; Hot Temperature; Neurons; Pain; Skin; Spinal Cord; Substance P | 1991 |
Parallel bioassay of PG-SPI, an amphibian acidic SP-like peptide, mammalian basic substance P, and neurokinins A and B on in vitro and in vivo test systems.
Topics: Amino Acid Sequence; Animals; Biological Assay; Biphenyl Compounds; Cricetinae; Evaluation Studies as Topic; Gastric Mucosa; Guinea Pigs; Injections, Intraventricular; Male; Molecular Sequence Data; Neurokinin A; Neurokinin B; Oligopeptides; Organ Culture Techniques; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rabbits; Ranidae; Rats; Rats, Wistar; Receptors, Tachykinin; Substance P | 1995 |
Suppression of a nonselective cation conductance by substance P in cochlear outer hair cells.
Topics: Animals; Biphenyl Compounds; Calcium; Cations; Cell Membrane Permeability; Chelating Agents; Electric Conductivity; GTP-Binding Proteins; Guinea Pigs; Hair Cells, Auditory, Outer; Patch-Clamp Techniques; Protein Kinase Inhibitors; Substance P | 1995 |
Cardiovascular effects of a specific nonpeptide antagonist of substance P (NK-1) receptor in DOCA-salt hypertension.
Topics: Animals; Biphenyl Compounds; Blood Pressure; Cardiac Output; Cardiac Volume; Desoxycorticosterone; Heart Rate; Hemodynamics; Hypertension; Hypnotics and Sedatives; Male; Neurokinin-1 Receptor Antagonists; Rats; Rats, Wistar; Sodium Chloride; Substance P; Vascular Resistance | 1995 |
Comparison of the effects of (+/-) CP 96,345 and L-668,169 on neurokinin receptor mediated responses in rat and guinea-pig isolated tissues.
Topics: Animals; Biphenyl Compounds; Eledoisin; Guinea Pigs; Ileum; Male; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Neurokinin-1 Receptor Antagonists; Organ Specificity; Peptide Fragments; Peptides, Cyclic; Portal Vein; Rats; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Species Specificity; Substance P; Urinary Bladder | 1993 |
Pharmacological evidence for involvement of excitatory amino acids in aversive responses induced by intrathecal substance P in rats.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Biphenyl Compounds; Injections, Spinal; Kainic Acid; Male; N-Methylaspartate; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Neurokinin-1; Substance P | 1993 |
Evidence that substance P is utilized in medial amygdaloid facilitation of defensive rage behavior in the cat.
Topics: Amygdala; Animals; Axons; Biphenyl Compounds; Cats; Electric Stimulation; Female; Hypothalamus, Middle; Male; Microinjections; Nerve Endings; Neurokinin-1 Receptor Antagonists; Predatory Behavior; Rage; Reaction Time; Substance P | 1993 |
A new selective bioassay for tachykinin NK3 receptors based on inositol monophosphate accumulation in the guinea pig ileum.
Topics: Animals; Biphenyl Compounds; Guinea Pigs; Hypnotics and Sedatives; Ileum; In Vitro Techniques; Inositol Phosphates; Male; Muscle, Smooth; Neurokinin A; Peptide Fragments; Phosphatidylinositols; Phospholipids; Receptors, Neurokinin-3; Stimulation, Chemical; Substance P; Tachykinins | 1993 |
Conserved HisVI-17 of the NK-1 receptor is involved in binding of non-peptide antagonists but not substance P.
Topics: Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; Biphenyl Compounds; Cell Line; Cell Membrane; Conserved Sequence; Dipeptides; Humans; Indoles; Isoindoles; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Neurokinin-1 Receptor Antagonists; Piperidines; Protein Structure, Secondary; Quinuclidines; Receptors, Neurokinin-1; Recombinant Proteins; Sequence Homology, Amino Acid; Substance P; Transfection | 1993 |
Inhibitory effect of CP-96,345, a non-peptide neurokinin-1-receptor antagonist, on neurogenic responses of guinea-pig isolated airway smooth muscle.
Topics: Acetylcholine; Animals; Biphenyl Compounds; Bronchi; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Substance P; Trachea | 1993 |
Substance P increases neutrophil adhesion to bronchial epithelial cells.
Topics: Animals; Biphenyl Compounds; Bronchi; Cattle; Cell Adhesion; Cell Adhesion Molecules; Epithelium; Humans; In Vitro Techniques; Intercellular Adhesion Molecule-1; Lymphocyte Function-Associated Antigen-1; Macrophage-1 Antigen; Neurokinin-1 Receptor Antagonists; Neutrophils; Peptide Fragments; Rosette Formation; Substance P; Time Factors | 1994 |
CP-96,345, a substance P antagonist, inhibits rat intestinal responses to Clostridium difficile toxin A but not cholera toxin.
Topics: Animals; Bacterial Toxins; Biphenyl Compounds; Cholera Toxin; Clostridioides difficile; Diarrhea; Enterocolitis; Enterotoxins; Ileum; Male; Mast Cells; Rats; Rats, Wistar; Substance P | 1994 |
The species selectivity of chemically distinct tachykinin nonpeptide antagonists is dependent on common divergent residues of the rat and human neurokinin-1 receptors.
Topics: Amino Acid Sequence; Animals; Benzamides; Biphenyl Compounds; Cell Line; Dipeptides; Humans; Indoles; Molecular Sequence Data; Mutation; Neurokinin-1 Receptor Antagonists; Piperidines; Rats; Receptors, Neurokinin-1; Recombinant Proteins; Substance P | 1994 |
Differences in the effects of tachykinin NK1 receptor antagonists: neuronal versus smooth muscle tissues.
Topics: Animals; Biphenyl Compounds; Electrophysiology; Guinea Pigs; Ileum; In Vitro Techniques; Indoles; Isoindoles; Locus Coeruleus; Male; Muscle, Smooth; Myenteric Plexus; Neurokinin-1 Receptor Antagonists; Neurons; Peptides, Cyclic; Rats; Rats, Sprague-Dawley; Substance P; Superior Cervical Ganglion; Urinary Bladder | 1993 |
Blockade of tachykinin NK1 receptors by CP-96345 enhances dopamine release and the striatal dopamine effects of methamphetamine in rats.
Topics: Animals; Biphenyl Compounds; Corpus Striatum; Dopamine; Dynorphins; Male; Methamphetamine; Microdialysis; Neurokinin-1 Receptor Antagonists; Neurotensin; Rats; Rats, Sprague-Dawley; Substance P; Substantia Nigra | 1993 |
Substance P-induced contractions of the guinea-pig proximal colon through stimulation of post-junctional tachykinin NK1 receptors.
Topics: Androstanes; Androstenes; Animals; Benzimidazoles; Biphenyl Compounds; Colon; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Neuromuscular Junction; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 1993 |
Antagonism of substance P and related peptides by RP 67580 and CP-96,345, at tachykinin NK1 receptor sites, in the rat urinary bladder.
Topics: Animals; Biphenyl Compounds; Blood Proteins; Female; Hypnotics and Sedatives; In Vitro Techniques; Indoles; Isoindoles; Male; Muscle Contraction; Muscle, Smooth; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Urinary Bladder | 1994 |
Neurotrophic effects of substance P on hippocampal neurons in vitro.
Topics: Animals; Biphenyl Compounds; Cells, Cultured; Culture Media, Conditioned; Hippocampus; Neurokinin-1 Receptor Antagonists; Neurons; Polymerase Chain Reaction; Rats; Receptors, Neurokinin-1; RNA, Messenger; Substance P | 1993 |
Blockade of cardiac inflammation in Mg2+ deficiency by substance P receptor inhibition.
Topics: Animals; Biphenyl Compounds; Calcitonin Gene-Related Peptide; Cytokines; Glutathione; Magnesium Deficiency; Male; Myocardium; Neuropeptides; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Thiobarbituric Acid Reactive Substances; Tumor Necrosis Factor-alpha | 1994 |
In vivo characterization of the tachykinin receptors involved in the direct and indirect bronchoconstrictor effect of tachykinins in two inbred rat strains.
Topics: Airway Resistance; Animals; Atropine; Biphenyl Compounds; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Captopril; Dose-Response Relationship, Drug; Indoles; Isoindoles; Male; Methysergide; Neurokinin A; Rats; Rats, Inbred F344; Rats, Inbred Strains; Receptors, Tachykinin; Serotonin; Substance P; Thiorphan | 1994 |
Substance P receptors on human astrocytoma cells are linked to glycogen breakdown.
Topics: Astrocytoma; Biphenyl Compounds; Brain Neoplasms; Dose-Response Relationship, Drug; Drug Combinations; Glycogen; Histamine; Humans; Norepinephrine; Receptors, Neurokinin-1; Substance P; Tumor Cells, Cultured | 1994 |
In vivo evidence for the activation of a septide-sensitive tachykinin receptor in guinea pig bronchoconstriction.
Topics: Animals; Biphenyl Compounds; Bronchial Spasm; Bronchoconstriction; Dose-Response Relationship, Drug; Guinea Pigs; Hypnotics and Sedatives; Male; Peptide Fragments; Physalaemin; Pyrrolidonecarboxylic Acid; Receptors, Tachykinin; Substance P; Sulfones | 1994 |
Involvement of substance P and excitatory amino acids in aversive behavior elicited by intrathecal capsaicin.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Animals; Avoidance Learning; Biphenyl Compounds; Capsaicin; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Hypnotics and Sedatives; Injections, Spinal; Male; Nociceptors; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reinforcement, Psychology; Substance P; Synaptic Transmission | 1994 |
Comparison of tachykinin NK1 receptors in human IM9 and U373 MG cells, using antagonist (FK888, (+/-)-CP-96,345, and RP 67580) binding.
Topics: Astrocytoma; Biphenyl Compounds; Dipeptides; Humans; Indoles; Isoindoles; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Receptors, Neurokinin-1; Substance P; Tumor Cells, Cultured | 1994 |
Involvement of neurokinin 1 and 2 receptors in viscerosensitive response to rectal distension in rats.
Topics: Abdomen; Animals; Benzamides; Biphenyl Compounds; Colon; Colonic Diseases, Functional; Gastrointestinal Motility; Hypnotics and Sedatives; Indoles; Isoindoles; Male; Neurokinin A; Peptide Fragments; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Tachykinin; Rectum; Substance P; Tachykinins | 1994 |
Differences in the effects of NK1-receptor antagonists, (+/-)-CP 96,345 and CP 99,994, on agonist-induced responses in guinea-pig trachea.
Topics: Animals; Biphenyl Compounds; Guinea Pigs; In Vitro Techniques; Indoles; Isoindoles; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Substance P; Trachea | 1994 |
Cardiovascular and behavioural effects of centrally administered neuropeptide K in the rat: receptor characterization.
Topics: Animals; Behavior, Animal; Biphenyl Compounds; Blood Pressure; Heart Rate; Hemodynamics; Indoles; Injections, Intraventricular; Isoindoles; Male; Neurokinin-1 Receptor Antagonists; Neuropeptides; Oligopeptides; Rats; Rats, Wistar; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Neuropeptide; Substance P; Tachykinins | 1994 |
Ventilatory responses to hypoxia in rats pretreated with nonpeptide NK1 receptor antagonist CP-96,345.
Topics: Animals; Animals, Newborn; Biphenyl Compounds; Capsaicin; Female; Hypnotics and Sedatives; Hypoxia; In Vitro Techniques; Nerve Fibers; Neurokinin-1 Receptor Antagonists; Plethysmography; Rats; Rats, Inbred F344; Respiratory Function Tests; Respiratory Mechanics; Substance P; Tidal Volume | 1994 |
CGRP (8-37) reduces the duration but not the maximal increase of antidromic vasodilation in dental pulp and lip of the rat.
Topics: Afferent Pathways; Animals; Biphenyl Compounds; Blood Pressure; Calcitonin Gene-Related Peptide; Dental Pulp; Electric Stimulation; Evoked Potentials; Lip; Male; Mandibular Nerve; Peptide Fragments; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Substance P; Vasodilation | 1994 |
A further analysis of the contraction induced by activation of cholecystokinin A receptors in guinea pig isolated ileum longitudinal muscle-myenteric plexus.
Topics: Animals; Atropine; Biphenyl Compounds; Drug Interactions; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Neuromuscular Junction; Peptide Fragments; Peptides, Cyclic; Physalaemin; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin A; Receptors, Cholecystokinin; Substance P; Tetragastrin; Tetrodotoxin | 1994 |
Physiological and pharmacological characterization of the spinal tachykinin NK2 receptor.
Topics: Animals; Animals, Newborn; Biphenyl Compounds; Dose-Response Relationship, Drug; Drug Interactions; Ganglia, Spinal; Gerbillinae; Hypnotics and Sedatives; In Vitro Techniques; Indoles; Isoindoles; Neurokinin A; Oligopeptides; Peptide Fragments; Rats; Receptors, Neurokinin-2; Spinal Cord; Substance P; Tetrodotoxin | 1994 |
Corelease of neuropeptides from capsaicin-sensitive afferents dilates submucosal arterioles in guinea pig ileum.
Topics: Animals; Biphenyl Compounds; Calcitonin Gene-Related Peptide; Capsaicin; Drug Interactions; Guinea Pigs; Ileum; Intestinal Mucosa; Neurons, Afferent; Neuropeptides; Peptide Fragments; Substance P; Synaptic Membranes; Vasodilation | 1994 |
Substance P released endogenously by high-intensity sensory stimulation potentiates purinergic inhibition of nociceptive dorsal horn neurons induced by peripheral vibration.
Topics: Animals; Biphenyl Compounds; Caffeine; Cats; Electric Stimulation; Electrophysiology; Glutamic Acid; Hypnotics and Sedatives; Iontophoresis; Neurons; Peripheral Nerves; Skin; Spinal Cord; Substance P; Time Factors; Vibration | 1994 |
Tachykinins and kinins in antigen-evoked plasma extravasation in guinea-pig nasal mucosa.
Topics: Animals; Biphenyl Compounds; Bradykinin; Capillary Permeability; Capsaicin; Evans Blue; Glycopeptides; Guinea Pigs; Hypnotics and Sedatives; In Vitro Techniques; Kinins; Male; Nasal Mucosa; Nerve Endings; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Ovalbumin; Protease Inhibitors; Substance P; Tachykinins | 1994 |
Comparison of antagonistic effects of sendide and CP-96,345 on a spinally mediated behavioural response in mice.
Topics: Analgesics; Animals; Behavior, Animal; Biphenyl Compounds; Hypnotics and Sedatives; Injections; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Peptide Fragments; Postural Balance; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Spinal Cord; Subarachnoid Space; Substance P | 1994 |
Tachykinin-induced contractions in the circular muscle of guinea pig ileum.
Topics: Animals; Atropine; Biphenyl Compounds; Dose-Response Relationship, Drug; Electrophysiology; Guinea Pigs; Hypnotics and Sedatives; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Peptides, Cyclic; Rats; Structure-Activity Relationship; Substance P; Tachykinins; Tetrodotoxin | 1994 |
Involvement of substance P but not nitric oxide or calcitonin gene-related peptide in neurogenic plasma extravasation in rat incisor pulp and lip.
Topics: Animals; Arginine; Biphenyl Compounds; Calcitonin Gene-Related Peptide; Capillary Permeability; Dental Pulp; Electric Stimulation; Evans Blue; Gingiva; Incisor; Lip; Male; Mandibular Nerve; Neurons, Afferent; NG-Nitroarginine Methyl Ester; Nitric Oxide; Peptide Fragments; Plasma; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P | 1994 |
Neurogenic inflammation in the intestine.
Topics: Animals; Bacterial Toxins; Biphenyl Compounds; Cholera Toxin; Enteritis; Enterotoxins; Intestines; Nervous System Physiological Phenomena; Rats; Substance P | 1995 |
Substance P binding sites on intestinal lymphoid aggregates and blood vessels in inflammatory bowel disease correspond to authentic NK-1 receptors.
Topics: Binding Sites; Biphenyl Compounds; Blood Vessels; Humans; Indoles; Inflammatory Bowel Diseases; Intestinal Mucosa; Intestines; Isoindoles; Lymphoid Tissue; Neurokinin-1 Receptor Antagonists; Quinuclidines; Receptors, Neurokinin-1; Substance P | 1994 |
Effect of the tachykinin NK1 receptor antagonists, RP 67580 and SR 140333, on electrically-evoked substance P release from rat spinal cord.
Topics: Amino Acid Sequence; Analgesics; Animals; Biphenyl Compounds; Calcitonin Gene-Related Peptide; Electric Stimulation; Hypnotics and Sedatives; In Vitro Techniques; Indoles; Isoindoles; Male; Molecular Sequence Data; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Spinal Cord; Substance P | 1994 |
Effects of NK1 receptor antagonists on vasodilation induced by chemical and electrical activation of sensory C-fibre afferents in different organs.
Topics: Afferent Pathways; Animals; Biphenyl Compounds; Bronchial Arteries; Electric Stimulation; Indoles; Isoindoles; Laser-Doppler Flowmetry; Nasal Mucosa; Nerve Fibers; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Organ Specificity; Regional Blood Flow; Skin; Substance P; Swine; Vasodilation | 1994 |
Similar rates of phosphatidylinositol hydrolysis following activation of wild-type and truncated rat neurokinin-1 receptors.
Topics: Animals; Biphenyl Compounds; CHO Cells; Cricetinae; Inositol Phosphates; Phosphatidylinositols; Rats; Receptors, Neurokinin-1; Recombinant Proteins; Signal Transduction; Structure-Activity Relationship; Substance P; Time Factors; Transfection | 1995 |
Conversion of antagonist-binding site to metal-ion site in the tachykinin NK-1 receptor.
Topics: Allosteric Regulation; Amino Acid Sequence; Binding Sites; Biphenyl Compounds; Cell Line; Copper; Histidine; Humans; Models, Molecular; Molecular Sequence Data; Mutation; Neurokinin-1 Receptor Antagonists; Protein Conformation; Receptors, Neurokinin-1; Substance P; Zinc | 1995 |
Nitric oxide induces acetylcholine-mediated contractions in the guinea-pig small intestine.
Topics: Acetylcholine; Animals; Atropine; Biphenyl Compounds; Dose-Response Relationship, Drug; Guinea Pigs; Hexamethonium; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nitric Oxide; Substance P; Tetrodotoxin | 1994 |
Tachykinin receptors involved in the contractile effect of the natural tachykinins in the rat gastric fundus.
Topics: Animals; Biphenyl Compounds; Dose-Response Relationship, Drug; Female; Gastric Fundus; Indoles; Isoindoles; Male; Methacholine Chloride; Muscle Contraction; Neurokinin A; Neurokinin B; Peptide Fragments; Peptides, Cyclic; Rats; Receptors, Tachykinin; Substance P; Tachykinins | 1994 |
The involvement of substance P and neurokinin-1 receptors in the responses of rat dorsal horn neurons to noxious but not to innocuous mechanical stimuli applied to the knee joint.
Topics: Animals; Arthralgia; Biphenyl Compounds; Immunologic Techniques; Knee Joint; Male; Neural Pathways; Neurokinin-1 Receptor Antagonists; Neurons; Physical Stimulation; Rats; Rats, Wistar; Receptors, Neurokinin-1; Spinal Cord; Substance P | 1994 |
Illness-induced hyperalgesia is mediated by spinal neuropeptides and excitatory amino acids.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Biphenyl Compounds; Cholecystokinin; Disease; Excitatory Amino Acids; Hyperalgesia; Injections, Spinal; Lipopolysaccharides; Neuropeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Serotonin; Spinal Cord; Substance P | 1994 |
Modulation of acetylcholine release in rabbit airways in vitro.
Topics: Acetylcholine; Animals; Biphenyl Compounds; Bronchi; Chromatography, High Pressure Liquid; Electric Stimulation; Indomethacin; Rabbits; Substance P; Trachea; Vasoactive Intestinal Peptide | 1995 |
Synthesis and biological evaluation of NK1 antagonists derived from L-tryptophan.
Topics: Amines; Amino Acid Sequence; Animals; Binding Sites; Biphenyl Compounds; Cardiovascular System; CHO Cells; Cricetinae; Esters; Extravasation of Diagnostic and Therapeutic Materials; Female; Ferrets; Guinea Pigs; Heterocyclic Compounds; Humans; Hypnotics and Sedatives; Male; Molecular Sequence Data; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Solubility; Structure-Activity Relationship; Substance P; Tryptophan | 1995 |
Effects of intrathecally injected glutamate and substance P antagonists on repeated cold stress-induced hyperalgesia in rats.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Biphenyl Compounds; Cold Temperature; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Hyperalgesia; Hypnotics and Sedatives; Injections, Spinal; Male; Neurokinin-1 Receptor Antagonists; Nociceptors; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stress, Psychological; Substance P | 1995 |
Tachykinin NK1 and NK2 receptors mediate the non-cholinergic bronchospastic response to capsaicin and vagal stimulation in guinea-pigs.
Topics: Animals; Biphenyl Compounds; Bronchial Spasm; Capsaicin; Electric Stimulation; Guinea Pigs; Insufflation; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Peptides, Cyclic; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Vagus Nerve | 1995 |
Antagonism of nociceptive responses of cat spinal dorsal horn neurons in vivo by the NK-1 receptor antagonists CP-96,345 and CP-99,994, but not by CP-96,344.
Topics: Animals; Biphenyl Compounds; Cats; Hot Temperature; Hypnotics and Sedatives; Membrane Potentials; Neurokinin-1 Receptor Antagonists; Nociceptors; Piperidines; Spinal Cord; Spinal Nerve Roots; Substance P | 1995 |
Substance P-induced inflammatory responses in guinea-pig skin: the effect of specific NK1 receptor antagonists and the role of endogenous mediators.
Topics: Animals; Antibodies, Monoclonal; Biphenyl Compounds; Chlorpheniramine; Dihydropyridines; Dose-Response Relationship, Drug; Edema; Female; Guinea Pigs; Imidazoles; Indoles; Inflammation; Isoindoles; Neurokinin-1 Receptor Antagonists; Pyrans; Quinolones; Skin; Substance P; Time Factors | 1995 |
Tachykinin receptors mediating contraction of guinea pig lung strips.
Topics: Acetylcholine; Animals; Benzamides; Biphenyl Compounds; Dipeptides; Guinea Pigs; In Vitro Techniques; Lung; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Tachykinin; Substance P; Trachea | 1995 |
Calcitonin gene-related peptide, substance P and nitric oxide are involved in cutaneous inflammation following ultraviolet irradiation.
Topics: Animals; Arginine; Biphenyl Compounds; Calcitonin Gene-Related Peptide; Dermatitis; Edema; Hypnotics and Sedatives; Immunohistochemistry; Male; Miotics; NG-Nitroarginine Methyl Ester; Nitric Oxide; Peptide Fragments; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Skin; Substance P; Ultrasonography; Ultraviolet Rays | 1995 |
Involvement of substance P in ultraviolet irradiation-induced inflammation in rat skin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Dermatitis; Edema; Erythema; Hindlimb; Immunohistochemistry; Male; Nerve Fibers; Radiation Injuries, Experimental; Rats; Rats, Sprague-Dawley; Substance P; Ultraviolet Rays | 1995 |
Lack of potent antinociceptive activity by substance P antagonist CP-96,345 in the rat spinal cord.
Topics: Analgesics; Analysis of Variance; Animals; Binding, Competitive; Biphenyl Compounds; In Vitro Techniques; Male; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Spinal Cord; Substance P | 1993 |
In vitro stimulatory effect of substance P on hematopoiesis.
Topics: Antibodies, Monoclonal; Antigens, CD; Biphenyl Compounds; Blotting, Western; Bone Marrow Cells; Cells, Cultured; Colony-Forming Units Assay; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Erythropoietin; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoiesis; Hematopoietic Stem Cells; Humans; Interleukin-1; Interleukin-3; Interleukin-6; Kinetics; Monocytes; Recombinant Proteins; Substance P; Tumor Necrosis Factor-alpha | 1993 |
Non-peptide antagonists, CP-96,345 and RP 67580, distinguish species variants in tachykinin NK1 receptors.
Topics: Animals; Binding Sites; Biphenyl Compounds; Carbachol; Cell Line; Female; Guinea Pigs; Humans; Hydrolysis; Ileum; Indoles; Inositol Phosphates; Isoindoles; Male; Muscle, Smooth; Neurokinin B; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Tumor Cells, Cultured | 1993 |
Molecular basis for the species selectivity of the substance P antagonist CP-96,345.
Topics: Amino Acid Sequence; Animals; Base Sequence; Biphenyl Compounds; Humans; Molecular Sequence Data; Oligodeoxyribonucleotides; Rats; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Recombinant Fusion Proteins; Structure-Activity Relationship; Substance P | 1993 |
Effect of CP-96,345, a non-peptide NK1 receptor antagonist, against substance P-, bradykinin- and allergen-induced airway microvascular leakage and bronchoconstriction in the guinea pig.
Topics: Administration, Inhalation; Allergens; Animals; Biphenyl Compounds; Bradykinin; Bronchoconstriction; Extravasation of Diagnostic and Therapeutic Materials; Female; Guinea Pigs; Immunization; Injections, Intravenous; Microcirculation; Pulmonary Circulation; Substance P | 1993 |
Inhibitory action of (+/-)CP-96,345 on the cardiovascular responses to intrathecal substance P and neuropeptide K in the conscious freely moving rat.
Topics: Animals; Biphenyl Compounds; Bradykinin; Cardiovascular System; Hemodynamics; Injections, Intravenous; Injections, Spinal; Male; Neuropeptides; Rats; Rats, Wistar; Substance P; Tachykinins | 1993 |
Substance P (NK-1 receptor) antagonists: in vivo and in vitro activities in rats and guinea pigs.
Topics: Animals; Biphenyl Compounds; Blood Pressure; Guinea Pigs; In Vitro Techniques; Indoles; Isoindoles; Muscle, Smooth; Oligopeptides; Peptides; Rabbits; Rats; Rats, Wistar; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P | 1993 |
The role of neurokinin and N-methyl-D-aspartate receptors in synaptic transmission from capsaicin-sensitive primary afferents in the rat spinal cord in vitro.
Topics: 2-Amino-5-phosphonovalerate; Afferent Pathways; Animals; Biphenyl Compounds; Capsaicin; Ganglia, Spinal; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Neurokinin A; Neurons; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Spinal Cord; Substance P; Synapses; Synaptic Transmission | 1993 |
CP-96,345, but not its stereoisomer, CP-96,344, blocks the nociceptive responses to intrathecally administered substance P and to noxious thermal and chemical stimuli in the rat.
Topics: Animals; Biphenyl Compounds; Blood Pressure; Formaldehyde; Heart Rate; Hot Temperature; Injections, Spinal; Male; Pain; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Spinal Cord; Stereoisomerism; Substance P | 1993 |
Effects of interactions of naturally-occurring neuropeptides on blood flow in the rat knee joint.
Topics: Animals; Biphenyl Compounds; Calcitonin Gene-Related Peptide; Fiber Optic Technology; Hypnotics and Sedatives; Joints; Male; Neuropeptides; Rats; Rats, Wistar; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Regional Blood Flow; Substance P; Tachyphylaxis; Vasodilation | 1993 |
Analysis of a nonpeptide antagonist for substance P on myenteric neurons of guinea-pig small intestine.
Topics: Action Potentials; Adenylyl Cyclases; Animals; Binding, Competitive; Biphenyl Compounds; Colforsin; Electrophysiology; Ganglia; Guinea Pigs; Hypnotics and Sedatives; In Vitro Techniques; Intestine, Small; Membrane Potentials; Myenteric Plexus; Neurons; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P | 1993 |
Use of non-peptide tachykinin receptor antagonists to substantiate the involvement of NK1 and NK2 receptors in a spinal nociceptive reflex in the rat.
Topics: Animals; Benzamides; Biphenyl Compounds; Hypnotics and Sedatives; Injections, Spinal; Male; Neurokinin A; Nociceptors; Pain Measurement; Pain Threshold; Peptide Fragments; Piperidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Receptors, Tachykinin; Reflex; Spinal Cord; Substance P | 1993 |
Different behavioral profiles of the non-peptide substance P (NK1) antagonists CP-96,345 and RP 67580 in Swiss albino mice in the black-and-white box.
Topics: Animals; Behavior, Animal; Biphenyl Compounds; Exploratory Behavior; Hypnotics and Sedatives; Indoles; Isoindoles; Male; Mice; Psychomotor Performance; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P | 1993 |
Effects of capsaicin, (+/-)-CP-96,345 and SR 48968 on the bradykinin-induced airways microvascular leakage in guinea-pigs.
Topics: Animals; Autonomic Nervous System; Benzamides; Biphenyl Compounds; Bradykinin; Capillary Permeability; Capsaicin; Evans Blue; Guinea Pigs; Hypnotics and Sedatives; In Vitro Techniques; Nerve Endings; Neurokinin A; Piperidines; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P | 1993 |
Functional neurokinin 1 receptors for substance P are expressed by human vascular endothelium.
Topics: Autoradiography; Biphenyl Compounds; Blood; Calcium; Cells, Cultured; Endothelium, Vascular; Humans; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P | 1993 |
Synthesis of a nonpeptide carbon-11 labeled substance P antagonist for PET studies.
Topics: Animals; Biphenyl Compounds; Carbon Radioisotopes; Guinea Pigs; Isotope Labeling; Models, Biological; Substance P; Tissue Distribution; Tomography, Emission-Computed | 1993 |
Antinociception induced by CP 96,345, a non-peptide NK-1 receptor antagonist, in the mouse formalin and capsaicin tests.
Topics: Analgesics; Animals; Biphenyl Compounds; Capsaicin; Dose-Response Relationship, Drug; Formaldehyde; Hypnotics and Sedatives; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Naloxone; Pain; Pain Measurement; Postural Balance; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P | 1993 |
Involvement of capsaicin-sensitive afferent nerves in the intestinal motor alterations induced by intestinal anaphylaxis in rats.
Topics: Afferent Pathways; Anaphylaxis; Animals; Atropine; Biphenyl Compounds; Capsaicin; Electromyography; Female; Gastrointestinal Motility; Intestine, Small; Muscle, Smooth; Ovalbumin; Rats; Substance P | 1993 |
Evidence for the presence of a septide-sensitive tachykinin receptor in the circular muscle of the guinea-pig ileum.
Topics: Animals; Biphenyl Compounds; Dose-Response Relationship, Drug; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscles; Neurokinin A; Peptide Fragments; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Tachykinins | 1993 |
Receptor-mediated specific biological activity of a beta-amyloid protein fragment for NK-1 substance P receptors.
Topics: Amino Acid Sequence; Amyloid beta-Peptides; Animals; Biphenyl Compounds; Dose-Response Relationship, Drug; Guinea Pigs; Ileum; In Vitro Techniques; Kinetics; Male; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P | 1993 |
Low-dose intrathecal clonidine releases tachykinins in rat spinal cord.
Topics: Animals; Biphenyl Compounds; Clonidine; Decerebrate State; Hypnotics and Sedatives; Injections, Spinal; Neurokinin A; Peptide Fragments; Rats; Rats, Sprague-Dawley; Reflex; Spinal Cord; Substance P | 1993 |
Substance P modulates antigen-induced, IFN-gamma production in murine Schistosomiasis mansoni.
Topics: Animals; Antigens, Surface; Biphenyl Compounds; Female; Granuloma; Interferon-gamma; Interleukin-5; Lymphocyte Subsets; Membrane Glycoproteins; Mice; Mice, Inbred CBA; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Schistosomiasis mansoni; Spleen; Substance P; Tachykinins; Thy-1 Antigens | 1993 |
Two nonpeptide tachykinin antagonists act through epitopes on corresponding segments of the NK1 and NK2 receptors.
Topics: Animals; Benzamides; Binding Sites; Biphenyl Compounds; Cells, Cultured; Epitopes; Neurokinin A; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P | 1993 |
Effect of bradykinin and tachykinin receptor antagonist on xylene-induced cystitis in rats.
Topics: Administration, Intravesical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Bradykinin; Cystitis; Female; Rats; Rats, Wistar; Substance P; Xylenes | 1993 |
NK1 receptors mediate tachykinin-induced increase in microvascular clearance in hamster cheek pouch.
Topics: Animals; Biphenyl Compounds; Capsaicin; Cheek; Cricetinae; Macromolecular Substances; Male; Mesocricetus; Microcirculation; Neurokinin A; Neurokinin B; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P; Tachykinins | 1993 |
Facilitatory effects of substance P on the susceptibility to long-term potentiation in the visual cortex of adult rats.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Biphenyl Compounds; Evoked Potentials; Guanosine Diphosphate; In Vitro Techniques; Long-Term Potentiation; Membrane Potentials; Quinoxalines; Rats; Substance P; Synapses; Thionucleotides; Visual Cortex | 1993 |
Tachykinins contract the circular muscle of the human esophageal body in vitro via NK2 receptors.
Topics: Adolescent; Adult; Aged; Atropine; Benzamides; Biphenyl Compounds; Carbachol; Dose-Response Relationship, Drug; Esophagus; Glycopeptides; Humans; Isometric Contraction; Middle Aged; Muscle Contraction; Muscle, Smooth; Neprilysin; Neurokinin A; Neurokinin B; Piperidines; Receptors, Tachykinin; Substance P; Tachykinins; Tetrodotoxin | 1993 |
Role of kinins in the vascular extravasation evoked by antigen and mediated by tachykinins in guinea pig trachea.
Topics: Animals; Antigens; Biphenyl Compounds; Bradykinin; Capillary Permeability; Guinea Pigs; Kinins; Male; Neurons, Afferent; Ovalbumin; Substance P; Tachykinins; Trachea | 1993 |
The modulation of the monosynaptic reflex by substance P in the hemisected spinal cord preparation of the rat and gerbil.
Topics: Action Potentials; Animals; Biphenyl Compounds; Dose-Response Relationship, Drug; Electric Stimulation; Gerbillinae; Motor Neurons; Neurokinin-1 Receptor Antagonists; Rats; Rats, Inbred Strains; Reflex, Monosynaptic; Species Specificity; Specific Pathogen-Free Organisms; Spinal Cord; Substance P; Synaptic Transmission | 1993 |
Tachykinins, via NK1 receptor activation, play a relevant role in plasma protein extravasation evoked by allergen challenge in the airways of sensitized guinea-pigs.
Topics: Allergens; Animals; Anti-Bacterial Agents; Biphenyl Compounds; Blood Proteins; Glycopeptides; Guinea Pigs; Hypnotics and Sedatives; Immunization; Male; Microcirculation; Neurokinin-1 Receptor Antagonists; Ovalbumin; Receptors, Neurokinin-1; Respiratory System; Substance P | 1993 |
Role of substance P in regulating sympatho-adrenal function in conscious rats.
Topics: Adrenal Glands; Animals; Biphenyl Compounds; Blood Glucose; Epinephrine; Injections, Spinal; Male; Neurokinin-1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Neurokinin-1; Reference Values; Spinal Cord; Substance P; Thyrotropin-Releasing Hormone | 1993 |
Comparison of effects of morphine and CP-96,345, a substance P antagonist, administered intrathecally on the somatosympathetic reflex discharges in anesthetized rats.
Topics: Animals; Biphenyl Compounds; Heart; Injections, Spinal; Male; Morphine; Naloxone; Neurokinin-1 Receptor Antagonists; Rats; Rats, Wistar; Reflex; Spinal Cord; Substance P; Sympathetic Nervous System | 1993 |
Selective blockade of sensory response of the carotid body to hypoxia by NK-1 receptor antagonist CP-96,345.
Topics: Animals; Biphenyl Compounds; Carotid Body; Cats; Chemoreceptor Cells; Dose-Response Relationship, Drug; Hypoxia; In Vitro Techniques; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Oxygen; Partial Pressure; Receptors, Neurokinin-1; Substance P | 1993 |
Pharmacological properties of a slow C-fiber response induced by stimulation of greater splanchnic nerve in an isolated spinal cord-nerve preparation of the newborn rat.
Topics: Animals; Animals, Newborn; Biphenyl Compounds; Evoked Potentials; Galanin; In Vitro Techniques; Morphine; Naloxone; Nerve Fibers; Neurokinin-1 Receptor Antagonists; Peptides; Rats; Receptors, Neurokinin-1; Spinal Cord; Spinal Nerve Roots; Splanchnic Nerves; Substance P | 1993 |
Functional characterization of neurokinin receptors with agonists and antagonists.
Topics: Amino Acid Sequence; Animals; Biphenyl Compounds; Guinea Pigs; Molecular Sequence Data; Muscle, Smooth; Muscle, Smooth, Vascular; Neurokinin A; Neurokinin B; Portal Vein; Rabbits; Rats; Receptors, Tachykinin; Structure-Activity Relationship; Substance P; Tachykinins; Trachea; Venae Cavae | 1993 |
Role of NK-1 receptor in central cardiovascular regulation in rats: studies on a novel non-peptide antagonist, CP-96,345, of substance P NK-1 receptor.
Topics: Animals; Biphenyl Compounds; Blood Pressure; Cerebral Ventricles; Heart Rate; Hypnotics and Sedatives; Injections, Intraventricular; Male; Muscle Contraction; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Rats; Receptors, Neurokinin-1; Substance P; Tachykinins; Vas Deferens | 1993 |
Variations in affinities for the NK1 receptor: differences between the non-peptide substance P antagonists RP 67580 and CP-96,345 and the agonist septide.
Topics: Animals; Binding, Competitive; Biphenyl Compounds; Brain; Cell Line; Dogs; Guinea Pigs; Humans; Indoles; Isoindoles; Mice; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Receptors, Neurokinin-1; Submandibular Gland; Substance P | 1993 |
Differences in the potency of CP-96345 and RP-67580, two new non-peptide antagonists selective for NK1 receptors, in inhibiting responses evoked by stimulation of sensory nerves.
Topics: Animals; Biphenyl Compounds; Blood Pressure; Bronchi; Capsaicin; Electric Stimulation; Guanethidine; Guinea Pigs; Indoles; Isoindoles; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Peripheral Nerves; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Regional Blood Flow; Skin; Substance P; Ureter | 1993 |
Evidence for NK-1 receptor subtypes from in vivo bronchopulmonary and cardiovascular studies.
Topics: Animals; Biphenyl Compounds; Blood Pressure; Bronchi; Bronchoconstriction; Guinea Pigs; Indoles; Isoindoles; Lung; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 1993 |
In vivo and in vitro activity of SR 48,968, a non-peptide tachykinin NK-2 receptor antagonist.
Topics: Animals; Benzamides; Biphenyl Compounds; Blood Pressure; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Piperidines; Rats; Receptors, Neurokinin-2; Saliva; Substance P; Sulfones; Urinary Bladder | 1993 |
Different behavioral profiles of the non-peptide substance P (NK-1) antagonists CP-96,345 and RP 67580.
Topics: Animals; Biphenyl Compounds; Indoles; Isoindoles; Mice; Motor Activity; Naloxone; Neurokinin-1 Receptor Antagonists; Stereotyped Behavior; Substance P | 1993 |
In vivo characterization of tachykinin receptors responsible for the central cardiovascular effects of substance P and neurokinin A.
Topics: Animals; Behavior, Animal; Biphenyl Compounds; Blood Pressure; Heart Rate; Neurokinin A; Oligopeptides; Peptide Fragments; Rats; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Stereotyped Behavior; Substance P | 1993 |
Effect of the nonpeptide NK-1 receptor antagonist CP-96,345 on the morphine withdrawal response of guinea-pigs.
Topics: Animals; Biphenyl Compounds; Cerebral Ventricles; Guinea Pigs; Hypnotics and Sedatives; Injections, Intraventricular; Morphine; Motor Activity; Naloxone; Neurokinin-1 Receptor Antagonists; Stereotyped Behavior; Substance P; Substance Withdrawal Syndrome | 1993 |
Effect of CP-96,345 on the [Met5]enkephalin washout withdrawal response of the guinea-pig isolated ileum.
Topics: Acetylcholine; Animals; Biphenyl Compounds; Enkephalin, Methionine; Female; Guinea Pigs; Hypnotics and Sedatives; Ileum; In Vitro Techniques; Male; Muscle, Smooth; Substance P; Substance Withdrawal Syndrome | 1993 |
Tachykinin NK-1 and NK-2 receptors in the circular muscle of the guinea-pig proximal colon.
Topics: Animals; Benzamides; Biphenyl Compounds; Colon; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Peptides, Cyclic; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Sulfones; Tetrodotoxin | 1993 |
Intrathecal administration of NK1 receptor antagonist, CP96345, inhibits the micturition reflex in the rat.
Topics: Animals; Biphenyl Compounds; Female; Injections, Spinal; Male; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, Neurokinin-1; Reflex; Spinal Cord; Substance P; Urinary Bladder; Urination | 1993 |
The effects of NK-1 and NK-2 receptor antagonists on the capsaicin evoked synaptic response in the rat spinal cord in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Biphenyl Compounds; Capsaicin; In Vitro Techniques; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Spinal Cord; Substance P; Synapses | 1993 |
Receptor characterization of the spinal action of neurokinins on nociception: a three receptor hypothesis.
Topics: Animals; Benzamides; Biphenyl Compounds; Models, Neurological; Neurokinin A; Neurokinin-1 Receptor Antagonists; Oligopeptides; Pain; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Neurotransmitter; Spinal Cord; Substance P | 1993 |
Is the selective non-peptide NK-1 receptor antagonist CP96,345 a peripherally acting analgesic?
Topics: Analgesics; Animals; Biphenyl Compounds; Dose-Response Relationship, Drug; Inflammation; Male; Mice; Mice, Inbred Strains; Motor Activity; Neurokinin-1 Receptor Antagonists; Substance P | 1993 |
Non-specific activity of (+/-)CP-96,345 in models of pain and inflammation.
Topics: Animals; Biphenyl Compounds; Carrageenan; Dose-Response Relationship, Drug; Edema; Hyperalgesia; Hypnotics and Sedatives; Inflammation; Neurokinin-1 Receptor Antagonists; Pain; Rats; Stereoisomerism; Substance P; Time Factors; Verapamil | 1993 |
Effect of CP-96,345 a non-peptide substance P antagonist, capsaicin, resiniferatoxin and ruthenium red on nociception.
Topics: Action Potentials; Analgesics; Animals; Biphenyl Compounds; Capsaicin; Diterpenes; Hot Temperature; Injections, Spinal; Pain; Peripheral Nerves; Rats; Ruthenium Red; Spinal Cord; Spinal Nerve Roots; Stereoisomerism; Substance P | 1993 |
Antiinflammatory and analgesic activity of CP-96,345: an orally active non-peptide substance P receptor antagonist.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Bradykinin; Dose-Response Relationship, Drug; Evans Blue; Guinea Pigs; Histamine; Leukotriene D4; Male; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Platelet Activating Factor; Receptors, Neurokinin-1; Skin; Substance P; Ureter | 1993 |
Capsaicin increases airflow resistance in guinea pigs in vivo by activating both NK2 and NK1 tachykinin receptors.
Topics: Airway Resistance; Animals; Atropine; Benzamides; Biphenyl Compounds; Capsaicin; Dose-Response Relationship, Drug; Drug Interactions; Guinea Pigs; Histamine; Male; Neurokinin A; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 1993 |
Cardiovascular effects of intrathecal administration of agents active at 5-hydroxytryptamine1-receptors in the rat: modulation by substance P and a substance P antagonist.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Biphenyl Compounds; Blood Pressure; Heart Rate; Hypnotics and Sedatives; Injections, Spinal; Male; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin Receptor Agonists; Spinal Cord; Substance P; Tetrahydronaphthalenes; Time Factors | 1993 |
The interaction of the NK1 receptor antagonist CP-96,345 with L-type calcium channels and its functional consequences.
Topics: Animals; Biphenyl Compounds; Calcium Channels; Cerebral Cortex; Diltiazem; Guinea Pigs; In Vitro Techniques; Male; Membranes; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Neurokinin-1 Receptor Antagonists; Nimodipine; Rats; Rats, Sprague-Dawley; Rats, Wistar; Stereoisomerism; Substance P; Succinimides; Trachea | 1993 |
Tachykinin-mediated respiratory effects in conscious guinea pigs: modulation by NK1 and NK2 receptor antagonists.
Topics: Aerosols; Animals; Biphenyl Compounds; Capsaicin; Cell Membrane; Guinea Pigs; Hypnotics and Sedatives; In Vitro Techniques; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neuropeptides; Receptors, Neurokinin-2; Respiration; Substance P; Tachykinins | 1993 |
Substance P-evoked calcium mobilization and ionic current activation in the human astrocytoma cell line U 373 MG: pharmacological characterization.
Topics: Astrocytoma; Biphenyl Compounds; Calcium; Cell Line; Cytosol; Fluorescent Dyes; Humans; Indoles; Ion Channels; Isoindoles; Membrane Potentials; Quinuclidines; Receptors, Neurokinin-1; Receptors, Tachykinin; Spectrometry, Fluorescence; Substance P; Tumor Cells, Cultured | 1993 |
The inhibitory effect of substance P antagonist, CP-96,345, on the late discharges of nociceptive neurons in the rat superficial spinal dorsal horn.
Topics: Animals; Biphenyl Compounds; Electric Stimulation; Electrophysiology; Female; Hypnotics and Sedatives; Nerve Fibers; Nerve Fibers, Myelinated; Neurons; Nociceptors; Physical Stimulation; Rats; Rats, Wistar; Spinal Cord; Substance P | 1993 |
Effects of FK224, a novel cyclopeptide NK1 and NK2 antagonist, and CP-96,345, a nonpeptide NK1 antagonist, on development and maintenance of thermal hyperesthesia evoked by carrageenan injection in the rat paw.
Topics: Animals; Biphenyl Compounds; Carrageenan; Extremities; Hot Temperature; Hyperesthesia; Male; Neurokinin A; Peptides, Cyclic; Rats; Rats, Sprague-Dawley; Substance P | 1993 |
Intracarotid substance P infusion inhibits ventilation in the goat.
Topics: Anesthesia; Animals; Biphenyl Compounds; Blood Gas Analysis; Blood Pressure; Carotid Body; Denervation; Depression, Chemical; Female; Goats; Immunohistochemistry; Infusions, Intra-Arterial; Male; Phrenic Nerve; Respiration; Respiratory Mechanics; Substance P | 1995 |
In vitro and in vivo studies of substance P receptor expression in rats with the new analog [indium-111-DTPA-Arg1]substance P.
Topics: Animals; Arthritis, Experimental; Biphenyl Compounds; Female; Indium Radioisotopes; Male; Neurokinin-1 Receptor Antagonists; Pancreatic Neoplasms; Parotid Gland; Pentetic Acid; Radionuclide Imaging; Rats; Rats, Inbred Lew; Rats, Wistar; Receptors, Neurokinin-1; Submandibular Gland; Substance P; Tissue Distribution | 1996 |
Neuropeptide modulation of chemically induced skin irritation.
Topics: Administration, Cutaneous; Animals; Benzamides; Biphenyl Compounds; Capsaicin; Dermatitis, Contact; Dinitrofluorobenzene; Disease Models, Animal; Dose-Response Relationship, Drug; Ear, External; Female; Irritants; Mice; Mice, Inbred BALB C; Neurokinin A; Neuropeptides; Piperidines; Skin; Substance P; Synaptic Transmission | 1995 |
Identification of the site in the substance P (NK-1) receptor for modulation of peptide binding by sulfhydryl reagents.
Topics: Alkylation; Animals; Biphenyl Compounds; CHO Cells; Cricetinae; Cysteine; Kinetics; Maleimides; Membrane Glycoproteins; Mutagenesis, Site-Directed; Protein Binding; Rats; Receptors, Neurokinin-1; Recombinant Proteins; Structure-Activity Relationship; Substance P; Sulfhydryl Reagents | 1996 |
Inhibition of substance P-induced vascular leakage in rat by N-acetyl-neurotensin-(8-13).
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Esophagus; Fasting; Inflammation; Male; Neurokinin-1 Receptor Antagonists; Neurotensin; Organ Specificity; Peptide Fragments; Rats; Rats, Sprague-Dawley; Skin; Substance P; Urinary Bladder | 1995 |
Induction of negative hematopoietic regulators by neurokinin-A in bone marrow stroma.
Topics: Amino Acid Sequence; Benzamides; Biphenyl Compounds; Bone Marrow; Bone Marrow Cells; Cell Division; Cells, Cultured; Chemokine CCL4; Connective Tissue; Depression, Chemical; Erythroid Precursor Cells; Hematopoietic Stem Cells; Humans; Macrophage Inflammatory Proteins; Molecular Sequence Data; Monokines; Neurokinin A; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Transforming Growth Factor beta | 1996 |
Substance P hyperpolarizes vagal sensory neurones of the ferret.
Topics: 4-Aminopyridine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apamin; Benzamides; Biphenyl Compounds; Cations, Divalent; Cesium; Electrophysiology; Ferrets; In Vitro Techniques; Male; Neurons, Afferent; Nodose Ganglion; Patch-Clamp Techniques; Peptide Fragments; Piperidines; Potassium; Pyrrolidonecarboxylic Acid; Quaternary Ammonium Compounds; Receptors, Tachykinin; Substance P; Vagus Nerve | 1996 |
Substance P contributes to rapidly adapting receptor responses to pulmonary venous congestion in rabbits.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Blood Pressure; Dose-Response Relationship, Drug; Male; Microcirculation; Pulmonary Veins; Rabbits; Receptors, Cell Surface; Receptors, Tachykinin; Respiration; Substance P; Tachykinins | 1996 |
Augmentation of neurally evoked cholinergic bronchoconstrictor responses by prejunctional NK2 receptors in the guinea-pig.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Biphenyl Compounds; Bronchoconstriction; Bronchoconstrictor Agents; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; Male; Medulla Oblongata; Methacholine Chloride; Muscle, Smooth; Neurokinin A; Neurokinin B; Piperidines; Substance P | 1996 |
Medial amygdaloid suppression of predatory attack behavior in the cat: I Role of a substance P pathway from the medial amygdala to the medial hypothalamus.
Topics: Amygdala; Animals; Autoradiography; Biphenyl Compounds; Brain Mapping; Cats; Electric Stimulation; Female; Hypnotics and Sedatives; Hypothalamus, Middle; Male; Microinjections; Neural Pathways; Neurokinin-1 Receptor Antagonists; Predatory Behavior; Receptors, Neurokinin-1; Stereotaxic Techniques; Substance P | 1996 |
The tachykinin NK1 receptor mediates the migration-promoting effect of substance P on human skin fibroblasts in culture.
Topics: Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Cell Adhesion; Cell Movement; Cells, Cultured; Dipeptides; Dose-Response Relationship, Drug; Fibroblasts; Humans; Indoles; Male; Neurokinin-1 Receptor Antagonists; Peptides, Cyclic; Platelet-Derived Growth Factor; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Skin; Substance P | 1996 |
[Study on a role of substance P in the spinal mechanisms of electroacupuncture analgesia].
Topics: Acupuncture Analgesia; Animals; Biphenyl Compounds; Electroacupuncture; Hypnotics and Sedatives; Indoles; Isoindoles; Naloxone; Narcotic Antagonists; Rats; Spinal Cord; Substance P | 1995 |
Substance P enhances electrical field stimulation-induced mast cell degranulation in rat trachea.
Topics: Animals; Biphenyl Compounds; Capsaicin; Cell Degranulation; Chymotrypsin; Dose-Response Relationship, Drug; Electric Stimulation; Indomethacin; Male; Mast Cells; Neurokinin A; Neurokinin-1 Receptor Antagonists; Osmolar Concentration; Rats; Rats, Sprague-Dawley; Substance P; Trachea | 1996 |
Interactions between the mu opioid agonist DAMGO and substance P in regulation of the ventral pallidum.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Biphenyl Compounds; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Extracellular Space; Globus Pallidus; Iontophoresis; Male; Microelectrodes; Neural Conduction; Neurokinin-1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Substance P; Tachykinins | 1996 |
A possible involvement of monoaminergic and opioidergic systems in the analgesia induced by electro-acupuncture in rabbits.
Topics: Acupuncture Analgesia; Analgesics, Opioid; Animals; Biogenic Monoamines; Biphenyl Compounds; Dental Pulp; Electroacupuncture; Evoked Potentials; Hypnotics and Sedatives; Male; Methysergide; Morphine; Naloxone; Narcotic Antagonists; Neural Conduction; Opioid Peptides; Rabbits; Serotonin; Serotonin Antagonists; Substance P; Trigeminal Nuclei | 1996 |
SR 48968 specifically depresses neurokinin A- vs. substance P-induced hyperalgesia in a nociceptive withdrawal reflex.
Topics: Animals; Benzamides; Biphenyl Compounds; Dose-Response Relationship, Drug; Hyperalgesia; Injections, Spinal; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Pain Measurement; Pain Threshold; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 1996 |
Tachykinin receptors in guinea-pig airways: characterization using selective ligands.
Topics: Animals; Biphenyl Compounds; Female; Guinea Pigs; In Vitro Techniques; Lung; Male; Physalaemin; Radioligand Assay; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 1995 |
The spinal contribution of substance P to the generation and maintenance of inflammatory hyperalgesia in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Biphenyl Compounds; Carrageenan; Dose-Response Relationship, Drug; Foot; Formaldehyde; Hot Temperature; Hyperalgesia; Inflammation; Male; Neurokinin-1 Receptor Antagonists; Nociceptors; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P | 1996 |
Substance P-induced mitogenesis in human astrocytoma cells correlates with activation of the mitogen-activated protein kinase signaling pathway.
Topics: Amino Acid Sequence; Animals; Astrocytoma; Biphenyl Compounds; Calcium-Calmodulin-Dependent Protein Kinases; DNA; Enzyme Activation; Flavonoids; Genes, myc; Humans; Molecular Sequence Data; Phosphorylation; Rabbits; Receptors, Neurokinin-1; RNA, Messenger; Substance P | 1996 |
Sidestream smoke exposure enhances rapidly adapting receptor responses to substance P in young guinea pigs.
Topics: Adaptation, Physiological; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Blood Gas Analysis; Blood Pressure; Body Weight; Dose-Response Relationship, Drug; Guinea Pigs; Male; Neurokinin-1 Receptor Antagonists; Receptors, Neurokinin-1; Stimulation, Chemical; Substance P; Time Factors; Tobacco Smoke Pollution; Trachea | 1996 |
Effect of the non-peptide blocker (+/-) CP 96,345 on the cellular mechanism involved in the response to NK1 receptor stimulation in human skin fibroblasts.
Topics: Biphenyl Compounds; Bradykinin; Calcium; Cells, Cultured; Cyclic AMP; Cytosol; Dipeptides; Fibroblasts; Humans; Hydrolysis; Indoles; Neurokinin-1 Receptor Antagonists; Phosphatidylinositols; Physalaemin; Receptors, Neurokinin-1; Skin; Stimulation, Chemical; Substance P | 1996 |
Endogenous NO inhibits NANC but not cholinergic neurotransmission to circular muscle of guinea pig ileum.
Topics: Acetylcholine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apamin; Bethanechol; Biphenyl Compounds; Electric Stimulation; Guanethidine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Neurokinin-1 Receptor Antagonists; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Scopolamine; Substance P; Synaptic Transmission; Tetrodotoxin; Vasoactive Intestinal Peptide | 1996 |
Evidence for functional tachykinin NK1 receptors on human isolated small bronchi.
Topics: Benzamides; Biphenyl Compounds; Bronchi; Female; Hormone Antagonists; Humans; In Vitro Techniques; Indomethacin; Lung Neoplasms; Male; Middle Aged; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Substance P | 1996 |
Neurokinin receptors in the guinea pig ileum.
Topics: Acetylcholine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Biphenyl Compounds; Guinea Pigs; Ileum; Male; Myenteric Plexus; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Radioligand Assay; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Stereoisomerism; Structure-Activity Relationship; Substance P | 1996 |
Aerosolized tachykinin antagonists inhibit pentamidine-induce bronchoconstriction in guinea pigs.
Topics: Aerosols; Animals; Benzamides; Biphenyl Compounds; Bronchi; Bronchoconstriction; Capillary Permeability; Dose-Response Relationship, Drug; Guinea Pigs; Male; Pentamidine; Piperidines; Receptors, Neurokinin-2; Substance P | 1996 |
Protective effect of substance P on permeability of airway epithelial cells in culture.
Topics: Animals; Biphenyl Compounds; Bronchi; Cell Communication; Cells, Cultured; Dogs; Epithelial Cells; Humans; Intercellular Junctions; Neurokinin-1 Receptor Antagonists; Substance P | 1996 |
Substance P-induced IL-12 production by murine macrophages.
Topics: Adjuvants, Immunologic; Animals; Biphenyl Compounds; Dose-Response Relationship, Immunologic; Female; Interleukin-12; Kinetics; Lipopolysaccharides; Macrophages, Peritoneal; Mice; RNA, Messenger; Substance P; Up-Regulation | 1997 |
Role of substance P in blood pressure regulation in salt-dependent experimental hypertension.
Topics: Animals; Biphenyl Compounds; Blood Pressure; Desoxycorticosterone; Hypertension; Male; Neurokinin-1 Receptor Antagonists; Rats; Rats, Inbred WKY; Substance P; Vasodilator Agents | 1997 |
Increased substance P responses in dorsal root ganglia and intestinal macrophages during Clostridium difficile toxin A enteritis in rats.
Topics: Animals; Bacterial Toxins; Biphenyl Compounds; Clostridioides difficile; Enterotoxins; Ganglia, Spinal; Ileitis; Intestinal Mucosa; Lumbosacral Region; Macrophage Activation; Macrophages; Male; Rats; Rats, Wistar; RNA, Messenger; Substance P; Tumor Necrosis Factor-alpha | 1997 |
Receptors mediating tachykinin-evoked depolarisations of neurons in the neonatal rat spinal cord.
Topics: Animals; Animals, Newborn; Biphenyl Compounds; Evoked Potentials; In Vitro Techniques; Indoles; Isoindoles; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neurons; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Spinal Cord; Substance P; Tachykinins | 1996 |
Cutaneous vasodilation during dorsal column stimulation is mediated by dorsal roots and CGRP.
Topics: Animals; Biphenyl Compounds; Calcitonin Gene-Related Peptide; Electric Stimulation; Male; Peptide Fragments; Rats; Rats, Sprague-Dawley; Rhizotomy; Skin; Spinal Cord; Spinal Nerve Roots; Substance P; Vasodilation | 1997 |
Effect of substance P and receptor antagonists on secretion of lingual lipase and amylase from rat von Ebner's gland.
Topics: Amylases; Animals; Atropine; Biphenyl Compounds; Kinetics; Lipase; Male; Neurokinin-1 Receptor Antagonists; Propranolol; Rats; Rats, Sprague-Dawley; Salivary Glands; Substance P; Time Factors; Timolol; Tongue | 1997 |
Substance P in the dorsal vagal complex inhibits medullary TRH-induced gastric acid secretion in rats.
Topics: Animals; Biphenyl Compounds; Cerebral Ventricles; Gastric Acid; Kainic Acid; Male; Medulla Oblongata; Microinjections; Peptide Fragments; Pyrrolidonecarboxylic Acid; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Solitary Nucleus; Substance P; Thyrotropin-Releasing Hormone; Vagus Nerve | 1997 |
CP-96,345, which inhibits [3H] substance P binding, selectively inhibits the behavioral response to intrathecally administered N-methyl-D-aspartate, but not substance P, in the mouse.
Topics: Animals; Behavior, Animal; Biphenyl Compounds; Dose-Response Relationship, Drug; Hypnotics and Sedatives; Injections, Spinal; Male; Mice; N-Methylaspartate; Substance P | 1997 |
Bradykinin-mediated activation of renal sensory neurons due to prostaglandin-dependent release of substance P.
Topics: Animals; Biphenyl Compounds; Bradykinin; Indoles; Indomethacin; Isoindoles; Kidney; Male; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Piperidines; Prostaglandins; Prostaglandins E; Rats; Rats, Sprague-Dawley; Substance P | 1997 |
Characterization of non-peptide antagonist and peptide agonist binding sites of the NK1 receptor with fluorescent ligands.
Topics: Animals; Binding Sites; Binding, Competitive; Biphenyl Compounds; CHO Cells; COS Cells; Cricetinae; Dansyl Compounds; Fluorescence Polarization; Fluorescent Dyes; Humans; Ligands; Membrane Glycoproteins; Mutagenesis, Site-Directed; Neurokinin-1 Receptor Antagonists; Protein Structure, Secondary; Receptors, Neurokinin-1; Recombinant Proteins; Solubility; Spectrometry, Fluorescence; Substance P | 1997 |
Blockade of nitric oxide-evoked smooth muscle contractions by an inhibitor of guanylyl cyclase.
Topics: Animals; Biphenyl Compounds; Enzyme Inhibitors; Guanylate Cyclase; Guinea Pigs; In Vitro Techniques; Intestine, Small; Male; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Nitric Oxide; Signal Transduction; Substance P; Tetrodotoxin | 1997 |
A structural rationale for the design of water soluble peptide-derived neurokinin-1 antagonists.
Topics: Animals; Biphenyl Compounds; Dipeptides; Drug Design; Humans; In Vitro Techniques; Indoles; Models, Chemical; Models, Molecular; Molecular Mimicry; Neurokinin-1 Receptor Antagonists; Peptides; Rats; Solubility; Substance P; Tetrazoles; Tryptophan; Water | 1997 |
Electrophysiological evidence that neurokinin A acts via NK-1 receptors in the cat dorsal horn.
Topics: Animals; Benzamides; Biphenyl Compounds; Cats; Iontophoresis; Neurokinin A; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Spinal Cord; Stereoisomerism; Substance P; Synapses | 1997 |
Effect of single point mutations of the human tachykinin NK1 receptor on antagonist affinity.
Topics: Animals; Biphenyl Compounds; Calcium; CHO Cells; Cloning, Molecular; Cricetinae; Escherichia coli; Female; Fluorescent Dyes; Fura-2; Humans; Mutagenesis, Site-Directed; Neurokinin-1 Receptor Antagonists; Plasmids; Point Mutation; Radioligand Assay; Receptors, Neurokinin-1; Semliki forest virus; Substance P | 1997 |
Tachykinins may mediate capsaicin-induced, but not vagally induced motility in porcine antrum.
Topics: Animals; Benzamides; Biphenyl Compounds; Capsaicin; Electric Stimulation; Gastrointestinal Motility; Muscle Contraction; Neurokinin A; Neurokinin-1 Receptor Antagonists; Piperidines; Pyloric Antrum; Receptors, Neurokinin-2; Substance P; Swine; Tachykinins; Vagus Nerve | 1997 |
Role of substance P in several models of bladder inflammation.
Topics: Animals; Biphenyl Compounds; Cystitis; Disease Models, Animal; Female; Immunohistochemistry; Lipopolysaccharides; Neurokinin-1 Receptor Antagonists; Poly I-C; Rats; Substance P; Urinary Bladder; Urination; Xylenes | 1997 |
NK1 receptor antagonist blocks angiotensin II responses in renin transgenic rat medulla oblongata.
Topics: Angiotensin II; Animals; Animals, Genetically Modified; Biphenyl Compounds; Blood Pressure; Body Weight; In Vitro Techniques; Male; Medulla Oblongata; Neurokinin-1 Receptor Antagonists; Perfusion; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Renin; Solitary Nucleus; Substance P; Systole | 1998 |
Split-receptors in the tachykinin neurokinin-1 system--mutational analysis of intracellular loop 3.
Topics: Amino Acid Sequence; Animals; Biphenyl Compounds; COS Cells; GTP-Binding Proteins; Molecular Sequence Data; Mutation; Phosphatidylinositols; Receptors, Neurokinin-1; Recombinant Proteins; Signal Transduction; Substance P | 1998 |
Grain sorghum dust increases macromolecular efflux from the in situ nasal mucosa.
Topics: Animals; Biphenyl Compounds; Cricetinae; Dextrans; Dust; Edible Grain; Fluorescein-5-isothiocyanate; Indoles; Isoindoles; Male; Microcirculation; Nasal Mucosa; Neurokinin-1 Receptor Antagonists; Substance P | 1998 |
Involvement of spinal substance P and excitatory amino acids in inflammatory hyperalgesia in rats.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Carrageenan; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Freund's Adjuvant; Hyperalgesia; Male; Neurokinin-1 Receptor Antagonists; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Substance P | 1998 |
Two related neurokinin-1 receptor antagonists have overlapping but different binding sites.
Topics: Animals; Binding Sites; Biphenyl Compounds; COS Cells; Humans; Hypnotics and Sedatives; Models, Chemical; Mutagenesis, Site-Directed; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Stereoisomerism; Substance P | 1998 |
Substance P attenuates and DAMGO potentiates amygdala glutamatergic neurotransmission within the ventral pallidum.
Topics: Amygdala; Analgesics, Opioid; Animals; Biphenyl Compounds; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Evoked Potentials; Globus Pallidus; Glutamic Acid; Hypnotics and Sedatives; Male; Neurons; Neurotransmitter Agents; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Reaction Time; Stimulation, Chemical; Substance P; Synaptic Transmission | 1998 |
Effects of tachykinin NK1 receptor antagonists on vagal hyperreactivity and neuronal M2 muscarinic receptor function in antigen challenged guinea-pigs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Electric Stimulation; Eosinophilia; Guinea Pigs; Lung; Neurokinin A; Neurokinin-1 Receptor Antagonists; Ovalbumin; Peptide Fragments; Pilocarpine; Piperidines; Quinuclidines; Receptor, Muscarinic M2; Receptors, Muscarinic; Receptors, Tachykinin; Specific Pathogen-Free Organisms; Substance P; Trachea; Vagus Nerve | 1998 |
Substance P receptor expression in intestinal epithelium in clostridium difficile toxin A enteritis in rats.
Topics: Animals; Bacterial Toxins; Biphenyl Compounds; Clostridioides difficile; Enteritis; Enterotoxins; Ileum; In Situ Hybridization; Intestinal Mucosa; Kinetics; Male; Protein Biosynthesis; Rats; Rats, Wistar; Receptors, Neurokinin-1; RNA, Messenger; Substance P; Time Factors; Transcription, Genetic; Up-Regulation | 1998 |
Effect of substance P on the short-circuit current of rat nasal mucosal epithelium.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Disease Models, Animal; Electric Stimulation; Epithelium; Histamine H1 Antagonists; Histamine H2 Antagonists; Histamine Release; Male; Mast Cells; Nasal Mucosa; Pyrilamine; Ranitidine; Rats; Rats, Sprague-Dawley; Rhinitis, Allergic, Seasonal; Substance P | 1998 |
Derivation of a three-dimensional pharmacophore model of substance P antagonists bound to the neurokinin-1 receptor.
Topics: Binding Sites; Biphenyl Compounds; Crystallography, X-Ray; Ligands; Models, Molecular; Molecular Conformation; Neurokinin-1 Receptor Antagonists; Receptors, Neurokinin-1; Structure-Activity Relationship; Substance P | 1998 |
In vivo signal transduction of tetrodotoxin-sensitive nociceptive responses by substance P given into the planta of the mouse hind limb.
Topics: Action Potentials; Afferent Pathways; Animals; Biphenyl Compounds; Calcium Signaling; Egtazic Acid; Estrenes; GTP-Binding Proteins; Hindlimb; Inositol 1,4,5-Trisphosphate; Ion Transport; Male; Mice; Mice, Inbred Strains; Models, Neurological; Muscle Contraction; Neurons, Afferent; Neurotoxins; Nociceptors; Phosphatidylinositol Diacylglycerol-Lyase; Phosphodiesterase Inhibitors; Pyrrolidinones; Receptors, Neurokinin-1; Reflex; Signal Transduction; Substance P; Tetrodotoxin; Type C Phospholipases | 1998 |
Characterization of tachykinin receptors mediating bronchomotor and vasodepressor responses to neuropeptide gamma and substance P in the anaesthetized rabbit.
Topics: Anesthesia; Animals; Benzamides; Biphenyl Compounds; Bronchoconstriction; Drug Interactions; Glycopeptides; Neprilysin; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Protease Inhibitors; Rabbits; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Tachykinins; Vagus Nerve; Vasoconstriction | 1998 |
Action of substance P and interaction of calcitonin gene-related peptide and substance P on the cat antral circular muscle.
Topics: Animals; Atropine; Autoradiography; Biphenyl Compounds; Calcitonin Gene-Related Peptide; Cats; Colon; Immunohistochemistry; Muscle Contraction; Protein Binding; Pyloric Antrum; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Tetrodotoxin | 1998 |
Effect of intravenous substance P on laryngeal adductor activity in young dogs.
Topics: Animals; Biphenyl Compounds; Dogs; Electromyography; Infusions, Intravenous; Laryngeal Muscles; Laryngismus; Premedication; Reflex; Substance P; Time Factors | 1999 |
Pharmacological evidence that neuropeptides mediate part of the actions of scorpion venom on the guinea pig ileum.
Topics: Animals; Atropine; Biphenyl Compounds; Guinea Pigs; Ileum; In Vitro Techniques; Indoles; Isoindoles; Muscarinic Antagonists; Muscle Contraction; Neurokinin-1 Receptor Antagonists; Neuropeptides; Scorpion Venoms; Stereoisomerism; Substance P | 1999 |
Transgenic mice over-expressing substance P exhibit allodynia and hyperalgesia which are reversed by substance P and N-methyl-D-aspartate receptor antagonists.
Topics: Analgesics; Animals; Biphenyl Compounds; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Hot Temperature; Hyperalgesia; Ketamine; Male; Mice; Mice, Transgenic; Myelin Basic Protein; Neurokinin-1 Receptor Antagonists; Nociceptors; Promoter Regions, Genetic; Reaction Time; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Spinal Cord; Stress, Mechanical; Substance P | 1999 |
Central injections of capsaicin cause antidiuresis mediated through neurokinin-1 receptors in rat hypothalamus and vasopressin release.
Topics: Acetylcholine; Anesthesia; Animals; Atropine; Binding Sites; Biphenyl Compounds; Capsaicin; Diuresis; Dose-Response Relationship, Drug; Hypnotics and Sedatives; Injections, Intraventricular; Male; Microdialysis; Phenoxybenzamine; Rats; Rats, Wistar; Receptors, Neurokinin-1; Substance P; Supraoptic Nucleus; Time Factors; Timolol; Vasopressins | 1999 |
Chronic activation of neurokinin-1 receptor induces pulmonary hypertension in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Atmospheric Pressure; Biphenyl Compounds; Blood Pressure; Cardiac Output; Female; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Neurokinin-1 Receptor Antagonists; Pulmonary Wedge Pressure; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P; Vascular Resistance | 1999 |
Nanomolar concentrations of neuropeptides induce histamine release from peritoneal mast cells of a substrain of Wistar rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Biphenyl Compounds; Dose-Response Relationship, Drug; Histamine Release; Male; Mast Cells; Neurokinin A; Peritoneum; Piperidines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Species Specificity; Substance P; Tachykinins | 1999 |
Spinal actions of GR73632, a novel tachykinin NK1 receptor agonist.
Topics: Animals; Behavior, Animal; Biphenyl Compounds; Drug Interactions; Injections, Spinal; Male; Mice; Peptide Fragments; Receptors, Neurokinin-1; Spinal Cord; Substance P | 1999 |
Nociceptin-induced scratching, biting and licking in mice: involvement of spinal NK1 receptors.
Topics: Aggression; Analgesics, Opioid; Animals; Antibodies, Blocking; Behavior, Animal; Biphenyl Compounds; Dose-Response Relationship, Drug; Injections, Spinal; Male; Mice; Morphine; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neurons; Nociceptin; Opioid Peptides; Piperidines; Receptors, Neurokinin-1; Receptors, Opioid; Spinal Cord; Substance P | 1999 |
Intrathecal co-administration of NMDA antagonist and NK-1 antagonist reduces MAC of isoflurane in rats.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Alanine; Anesthetics, Inhalation; Animals; Biphenyl Compounds; Catheters, Indwelling; Drug Combinations; Excitatory Amino Acid Antagonists; Injections, Spinal; Isoflurane; Locomotion; Male; Neurokinin-1 Receptor Antagonists; Nociceptors; Pain; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Substance P; Synaptic Transmission; Valine | 1999 |
Substance P regulates the function of rabbit cultured osteoclast; increase of intracellular free calcium concentration and enhancement of bone resorption.
Topics: Analysis of Variance; Animals; Biological Assay; Biphenyl Compounds; Bone Resorption; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Osteoclasts; Rabbits; Substance P | 1999 |
Differential effects from parapyramidal region and rostral ventrolateral medulla mediated by substance P.
Topics: Animals; Biphenyl Compounds; Blood Pressure; Cardiovascular Physiological Phenomena; Cardiovascular System; Cats; Dose-Response Relationship, Drug; Electric Stimulation; Heart Rate; Homocysteine; Immune Sera; Injections, Spinal; Medulla Oblongata; Substance P; Time Factors | 1999 |
Increased expression of preprotachykinin-I and neurokinin receptors in human breast cancer cells: implications for bone marrow metastasis.
Topics: Benzamides; Biphenyl Compounds; Bone Marrow Cells; Bone Marrow Neoplasms; Breast Neoplasms; Cell Division; Female; Gene Expression Regulation, Neoplastic; Humans; In Situ Hybridization; Neurokinin-1 Receptor Antagonists; Piperidines; Protein Precursors; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Tachykinins; Tumor Cells, Cultured | 2000 |
Involvement of substance P in neutral endopeptidase modulation of carotid body sensory responses to hypoxia.
Topics: Animals; Biphenyl Compounds; Carotid Body; Cats; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Enkephalin, Methionine; Female; Glycopeptides; Hydrolysis; Hypoxia; Kinetics; Male; Neprilysin; Neurokinin-1 Receptor Antagonists; Oxygen; Receptors, Neurokinin-1; Substance P | 2000 |
Participation of neuropeptides in antigen-induced contraction of guinea pig bronchi via NK(2) but not NK(1) receptor stimulation.
Topics: Animals; Benzamides; Benzeneacetamides; Biphenyl Compounds; Bronchi; Bronchoconstriction; Female; gamma-Globulins; Guinea Pigs; Histamine H1 Antagonists; Leukotriene Antagonists; Male; Neurokinin-1 Receptor Antagonists; Neuropeptides; Penicillin G; Piperidines; Pyrilamine; Receptors, Neurokinin-2; Substance P; Thiazoles; Trachea | 2000 |
Substance P in the nucleus of the solitary tract augments bronchopulmonary C fiber reflex output.
Topics: Animals; Biphenyl Compounds; Blood Pressure; Bronchi; Capsaicin; Guinea Pigs; Heart Rate; Hemodynamics; Lung; Male; Microinjections; Nerve Fibers; Neurokinin-1 Receptor Antagonists; Phrenic Nerve; Reflex; Respiratory Mechanics; Solitary Nucleus; Substance P; Trachea | 2000 |
NK-1 receptor desensitization and neutral endopeptidase terminate SP-induced pancreatic plasma extravasation.
Topics: Animals; Biphenyl Compounds; Blood Pressure; Blood Proteins; Capillaries; Capillary Permeability; Capsaicin; Cell Membrane; Evans Blue; Glycopeptides; Infusions, Intravenous; Male; Neprilysin; Neurokinin-1 Receptor Antagonists; Neutrophils; Pancreas; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P | 2000 |
Diastereoselective intramolecular Ritter reaction: generation of a cis-fused hexahydro-4aH-indeno[1,2-b]pyridine ring system with 4a,9b-diangular substituents.
Topics: Biphenyl Compounds; Chromatography, Thin Layer; Crystallography, X-Ray; Cyclization; Magnetic Resonance Spectroscopy; Molecular Structure; Neurokinin-1 Receptor Antagonists; Piperidines; Pyridines; Receptors, Neurokinin-1; Stereoisomerism; Substance P | 2000 |
Neurokinin 1 and 2 receptors mediate cholera toxin secretion in rat jejunum.
Topics: Animals; Biphenyl Compounds; Chlorides; Cholera Toxin; Intestinal Mucosa; Jejunum; Male; Models, Biological; Neurokinin-1 Receptor Antagonists; Neurons; Peptide Fragments; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Sodium; Substance P | 2000 |
NK-1 antagonist reduces colonic inflammation and oxidative stress in dextran sulfate-induced colitis in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Colitis; Dextran Sulfate; Dinoprost; F2-Isoprostanes; Isomerism; Male; Neurokinin-1 Receptor Antagonists; Oxidative Stress; Rats; Rats, Sprague-Dawley; Substance P | 2000 |
Neuroimmunologic aspects of psoriasis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Biphenyl Compounds; Humans; Immunohistochemistry; Inflammation; Injections, Intralesional; Nerve Growth Factor; Neuroimmunomodulation; Neuropeptides; Peptide T; Psoriasis; Psychoneuroimmunology; Receptors, Nerve Growth Factor; Relaxation Therapy; Skin; Stress, Psychological; Substance P | 2000 |
Substance P antagonist (CP-96,345) inhibits HIV-1 replication in human mononuclear phagocytes.
Topics: Anti-HIV Agents; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Drug Interactions; Genes, Reporter; HIV Long Terminal Repeat; HIV-1; Humans; In Vitro Techniques; Neuroimmunomodulation; Neurokinin-1 Receptor Antagonists; Phagocytes; Receptors, Neurokinin-1; Substance P; Tumor Necrosis Factor-alpha; Virus Replication | 2001 |
Priming effects of substance P on calcium changes evoked by interleukin-8 in human neutrophils.
Topics: Adult; Biphenyl Compounds; Calcium; Calcium Channels; Calcium Signaling; Dose-Response Relationship, Drug; Drug Synergism; Egtazic Acid; Humans; Interleukin-8; Ion Transport; Neutrophils; Peptide Fragments; Pyrrolidonecarboxylic Acid; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Recombinant Proteins; Substance P | 2001 |
[Effect of substance P on the short-circuit current of nasal mucosal epithelium].
Topics: Animals; Biphenyl Compounds; Electrophysiology; Epithelium; Histamine H1 Antagonists; Histamine H2 Antagonists; Male; Nasal Mucosa; Ovalbumin; Pyrilamine; Ranitidine; Rats; Rats, Sprague-Dawley; Rhinitis, Allergic, Perennial; Substance P; Tetrodotoxin | 1998 |
Sustained blockade of neurokinin-1 receptors enhances serotonin neurotransmission.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Brain; Hippocampus; Male; Neurons; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Serotonin; Substance P; Synaptic Transmission; Time Factors | 2001 |
Effect of tachykinins on ascending and descending reflex pathway in rat small intestine.
Topics: Afferent Pathways; Animals; Biphenyl Compounds; Efferent Pathways; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Physalaemin; Rats; Rats, Wistar; Reaction Time; Receptors, Neurokinin-2; Reflex; Substance P; Tachykinins | 2002 |
A non-peptide substance P antagonist down-regulates SP mRNA expression in human mononuclear phagocytes.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Autocrine Communication; Biphenyl Compounds; Cells, Cultured; Chemokine CCL7; Chemokine CX3CL1; Chemokines, CX3C; Cytokines; DNA, Complementary; Down-Regulation; Gene Expression Regulation; HIV; HIV Infections; Humans; Interleukin-8; Leukocytes, Mononuclear; Membrane Proteins; Monocyte Chemoattractant Proteins; Neuroimmunomodulation; Oligonucleotide Array Sequence Analysis; Phagocytes; Receptors, Neurokinin-1; RNA, Messenger; Substance P; Virus Replication | 2002 |
Ruthenium red-sensitive cation channels, but not calcitonin gene-related peptide or substance P-mediated mechanisms, protect duodenal villi against acid-induced damage.
Topics: Acids; Animals; Biphenyl Compounds; Calcitonin Gene-Related Peptide; Capsaicin; Cations; Dose-Response Relationship, Drug; Duodenum; Hydrochloric Acid; Hydrogen-Ion Concentration; Intestinal Mucosa; Ion Channels; Male; Neurons, Afferent; Peptide Fragments; Rats; Rats, Sprague-Dawley; Ruthenium Red; Substance P | 2002 |
Substance P (NK(1)) receptor expression by human colonic epithelial cell line Caco-2.
Topics: Biphenyl Compounds; Caco-2 Cells; Calcium; Cells, Cultured; Colon; Dose-Response Relationship, Drug; Enzyme Activation; Epithelial Cells; Gene Expression Regulation; Humans; Kinetics; Mitogen-Activated Protein Kinases; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Receptors, Neurokinin-1; RNA, Messenger; Signal Transduction; Substance P | 2002 |
Substance P up-regulates macrophage inflammatory protein-1beta expression in human T lymphocytes.
Topics: Adult; Biphenyl Compounds; Cell Line; Cells, Cultured; Chemokine CCL4; Chemotaxis, Leukocyte; Dose-Response Relationship, Drug; Humans; Jurkat Cells; Kinetics; Macrophage Inflammatory Proteins; NF-kappa B; Substance P; T-Lymphocytes; Transcriptional Activation; Up-Regulation | 2002 |
Substance P via NK1 receptor facilitates hyperactive bladder afferent signaling via action of ROS.
Topics: Animals; Benzamides; Biphenyl Compounds; Cell Adhesion Molecules; Dose-Response Relationship, Drug; Drug Administration Routes; Electric Stimulation; Female; Free Radical Scavengers; Muscle Contraction; Neurokinin-1 Receptor Antagonists; Pelvis; Piperidines; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, Neurokinin-1; Reflex, Abnormal; Signal Transduction; Sodium Chloride; Substance P; Superoxide Dismutase; Urinary Bladder; Urinary Bladder, Neurogenic; Urination; Visceral Afferents | 2003 |
Long-term effects of decreased noradrenergic central nervous system innervation on pain behavior and opioid antinociception.
Topics: Analgesics, Opioid; Animals; Antibodies, Monoclonal; Behavior, Animal; Biphenyl Compounds; Central Nervous System; Denervation; Disease Models, Animal; Disease Progression; Female; Hyperalgesia; Immunohistochemistry; Immunotoxins; Injections, Intraventricular; Injections, Spinal; Lumbosacral Region; Male; Morphine; Norepinephrine; Pain; Pain Measurement; Pain Threshold; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Ribosome Inactivating Proteins, Type 1; Saporins; Spinal Cord; Substance P; Time | 2003 |
Characterisation of the response of equine digital arteries and veins to substance P.
Topics: Animals; Arteries; Biphenyl Compounds; Dose-Response Relationship, Drug; Endothelium, Vascular; Forelimb; Horses; Ibuprofen; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Substance P; Vasodilation; Vasodilator Agents; Veins | 2003 |
A non-peptide substance P antagonist (CP-96,345) inhibits morphine-induced NF-kappa B promoter activation in human NT2-N neurons.
Topics: Biphenyl Compounds; Cell Line; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Humans; Morphine; Neurons; NF-kappa B; Promoter Regions, Genetic; Substance P | 2004 |
Interleukin-1beta upregulates functional expression of neurokinin-1 receptor (NK-1R) via NF-kappaB in astrocytes.
Topics: Animals; Animals, Newborn; Astrocytes; Biphenyl Compounds; Caffeic Acids; Calcium; Calcium Signaling; Cell Line, Tumor; Cells, Cultured; Central Nervous System; Cytosol; Encephalitis; Gene Expression Regulation; Humans; Interleukin-1; NF-kappa B; Phenylethyl Alcohol; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; RNA, Messenger; Substance P; Up-Regulation | 2004 |
A key role of neurokinin 1 receptors in acute pancreatitis and associated lung injury.
Topics: Amylases; Animals; Biphenyl Compounds; Capillary Permeability; Ceruletide; Lung; Lung Diseases; Mice; Mice, Inbred BALB C; Neurokinin-1 Receptor Antagonists; Pancreatitis; Peroxidase; Receptors, Neurokinin-1; Substance P; Time Factors | 2005 |
The effect of CP96,345 on the expression of tachykinins and neurokinin receptors in acute pancreatitis.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Immunohistochemistry; Lung; Mice; Mice, Inbred BALB C; Models, Animal; Pancreas; Pancreatitis; Protein Precursors; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Substance P; Tachykinins | 2006 |
Role of substance P in hydrogen sulfide-induced pulmonary inflammation in mice.
Topics: Air Pollutants; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Capsaicin; Female; Hydrogen Sulfide; Inflammation Mediators; Lung; Male; Mice; Mice, Inbred BALB C; Mice, Mutant Strains; Neurokinin-1 Receptor Antagonists; Peroxidase; Pneumonia; Protein Precursors; Substance P; Tachykinins; TRPV Cation Channels | 2006 |
Suppression of autoimmune encephalomyelitis by a neurokinin-1 receptor antagonist--a putative role for substance P in CNS inflammation.
Topics: Adoptive Transfer; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Blood-Brain Barrier; Central Nervous System; Cytokines; Encephalomyelitis, Autoimmune, Experimental; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Immunohistochemistry; Inflammation; Intercellular Adhesion Molecule-1; Mice; Neurokinin-1 Receptor Antagonists; Substance P; T-Lymphocytes; Vascular Cell Adhesion Molecule-1 | 2006 |
An in vitro model of morphine withdrawal manifests the enhancing effect on human immunodeficiency virus infection of human T lymphocytes through the induction of substance P.
Topics: Biphenyl Compounds; Gene Expression Regulation; HIV; HIV Infections; HIV Long Terminal Repeat; Humans; Jurkat Cells; Morphine; RNA, Messenger; Substance P; Substance Withdrawal Syndrome; T-Lymphocytes; Virus Replication | 2006 |
Effect of CP-96,345 on the expression of adhesion molecules in acute pancreatitis in mice.
Topics: Acute Disease; Amylases; Animals; Biphenyl Compounds; Cell Adhesion; Ceruletide; Immunohistochemistry; Intercellular Adhesion Molecule-1; Lung; Mice; Mice, Inbred BALB C; Neurokinin-1 Receptor Antagonists; Pancreas; Pancreatitis; Peroxidase; Substance P; Vascular Cell Adhesion Molecule-1 | 2007 |
Sensory neuron and substance P involvement in symptoms of a zymosan-induced rat model of acute bowel inflammation.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Colitis; Colon; Disease Models, Animal; Enteric Nervous System; Ethanol; Inflammation Mediators; Male; Neurogenic Inflammation; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Oligonucleotides, Antisense; Pain; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; RNA, Messenger; Substance P; Sympathetic Nervous System; Zymosan | 2007 |
Neuropeptide substance P upregulates chemokine and chemokine receptor expression in primary mouse neutrophils.
Topics: Active Transport, Cell Nucleus; Animals; Biphenyl Compounds; CD11b Antigen; Cells, Cultured; Chemokine CCL3; Chemokine CCL4; Chemokine CXCL2; Chemokines; Chemokines, CC; Chemotaxis, Leukocyte; Dose-Response Relationship, Drug; I-kappa B Proteins; Inflammation; Macrophage Inflammatory Proteins; Male; Mice; Neuroimmunomodulation; Neutrophils; Nitriles; Receptors, CCR1; Receptors, Chemokine; Receptors, Interleukin-8B; Receptors, Neurokinin-1; Recombinant Proteins; RNA, Messenger; Signal Transduction; Substance P; Sulfones; Transcription Factor RelA; Up-Regulation | 2007 |
Role of PKC-delta on substance P-induced chemokine synthesis in pancreatic acinar cells.
Topics: Acetophenones; Animals; Benzopyrans; Biphenyl Compounds; Chemokine CCL2; Chemokine CCL3; Chemokine CXCL2; Chemokines; Dose-Response Relationship, Drug; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase Kinase 1; MAP Kinase Kinase Kinases; Mice; Neurokinin-1 Receptor Antagonists; NF-kappa B; Pancreas, Exocrine; Phosphorylation; Protein Kinase C-delta; Protein Kinase Inhibitors; Receptors, Neurokinin-1; Signal Transduction; Substance P; Time Factors; Transcription Factor AP-1 | 2008 |
Substance P acts via the neurokinin receptor 1 to elicit bronchoconstriction, oxidative stress, and upregulated ICAM-1 expression after oil smoke exposure.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Ascorbic Acid; Benzamides; Biphenyl Compounds; Blood Pressure; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Catechin; Intercellular Adhesion Molecule-1; Male; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Oxidative Stress; Petroleum; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Respiratory Distress Syndrome; Smoke; Smoke Inhalation Injury; Substance P; Up-Regulation | 2008 |
Phosphorylation of TRPV1 by neurokinin-1 receptor agonist exaggerates the capsaicin-mediated substance P release from cultured rat dorsal root ganglion neurons.
Topics: Analysis of Variance; Animals; Biphenyl Compounds; Capsaicin; Cells, Cultured; Enzyme Inhibitors; Ganglia, Spinal; Neurons; Peptide Fragments; Phosphorylation; Rats; Rats, Wistar; Receptors, Neurokinin-1; Substance P; Time Factors; TRPV Cation Channels | 2008 |
Substance P potentiates TGFbeta-1 production in lung epithelial cell lines.
Topics: Biphenyl Compounds; Cell Line; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Epithelial Cells; Humans; Lung; Neurotransmitter Agents; Substance P; Transforming Growth Factor beta1 | 2009 |
Substance P antagonist CP-96345 blocks lung vascular leakage and inflammation more effectively than its stereoisomer CP-96344 in a mouse model of smoke inhalation and burn injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Disease Models, Animal; Mice; Smoke; Stereoisomerism; Substance P | 2010 |
Substance P and calcitonin gene related peptide mediate pain in chronic pancreatitis and their expression is driven by nerve growth factor.
Topics: Animals; Biphenyl Compounds; Calcitonin Gene-Related Peptide; Drug Evaluation, Preclinical; Gene Expression Regulation; Injections, Spinal; Male; Nerve Growth Factor; Nociceptive Pain; Pain; Pain Measurement; Pancreatitis, Chronic; Peptide Fragments; Rats; Rats, Sprague-Dawley; Substance P | 2011 |
Volume transmission of substance P in striatum induced by intraplantar formalin injection attenuates nociceptive responses via activation of the neurokinin 1 receptor.
Topics: Analgesia; Animals; Biphenyl Compounds; Corpus Striatum; Formaldehyde; Genes, fos; Genes, Immediate-Early; Injections; Male; Neurokinin-1 Receptor Antagonists; Nociception; Protein Precursors; Rats; Rats, Wistar; Receptors, Neurokinin-1; RNA, Messenger; Substance P; Tachykinins; Time Factors; Up-Regulation | 2013 |
[The role of NMDA and NK1 receptors in cardiac nociceptive information transmissions in the spinal cords of rats].
Topics: Animals; Biphenyl Compounds; Capsaicin; Chest Pain; Dizocilpine Maleate; Heart; Male; Nociceptors; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Spinal Cord; Substance P; Synaptic Transmission | 2013 |
Substance P is essential for maintaining gut muscle contractility: a novel role for coneurotransmission revealed by botulinum toxin.
Topics: Acetylcholine; Animals; Biphenyl Compounds; Botulinum Toxins; Electric Stimulation; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Myosin Light Chains; Pyloric Antrum; Pylorus; Rats; Receptors, Neurokinin-1; Substance P | 2014 |
Substance P and the neurokinin-1 receptor regulate electroencephalogram non-rapid eye movement sleep slow-wave activity locally.
Topics: Animals; Biphenyl Compounds; Brain; Dose-Response Relationship, Drug; Electrodes, Implanted; Electroencephalography; Electromyography; Functional Laterality; Male; Mice, Inbred C57BL; Neurotransmitter Agents; Peptide Fragments; Polysomnography; Receptors, Neurokinin-1; Sleep Stages; Substance P | 2015 |
[Modulatory effect of neurokinin-1 and non-N-methyl-D-aspartate receptors on cardiosomatic reflex in rat spinal cord].
Topics: Animals; Biphenyl Compounds; Injections, Spinal; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Reflex; Spinal Cord; Substance P | 2014 |
SP and IL-33 together markedly enhance TNF synthesis and secretion from human mast cells mediated by the interaction of their receptors.
Topics: Biphenyl Compounds; Cell Line, Tumor; Humans; Interleukin-1 Receptor-Like 1 Protein; Interleukin-33; Luteolin; MAP Kinase Signaling System; Mast Cells; NF-kappa B; Piperidines; Receptors, Neurokinin-1; Substance P; Tumor Necrosis Factor-alpha | 2017 |