cp 96345 and cp 99994
cp 96345 has been researched along with cp 99994 in 16 studies
Research
Studies (16)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 14 (87.50) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Desai, MC; Lefkowitz, SL; Longo, KP; Snider, RM; Thadeio, PF | 1 |
| Cascieri, MA; Fong, TM; Hardwicke, S; Lewis, RT; MacIntyre, DE; MacLeod, AM; Merchant, KJ; Metzger, JM; Sadowski, S; Shepheard, S | 1 |
| Cascieri, MA; Hale, JJ; MacCoss, M; MacIntyre, DE; Mathre, DJ; Metzger, JM; Mills, SG; Qi, H; Sadowski, S; Shah, SK; Strader, CD | 1 |
| Beusen, DD; Marshall, GR; Shands, EF; Takeuchi, Y | 1 |
| Hill, RG; Longmore, J; Razzaque, Z; Shaw, D | 1 |
| Bowery, NG; Malcangio, M | 1 |
| Henry, JL; Radhakrishnan, V | 2 |
| Killingsworth, CR; Shore, SA | 1 |
| Chrétien, L; Gobeil, F; Jukic, D; Nguyen, QT; Nguyen-Le, XK; Regoli, D | 1 |
| Farley, DM; Kopp, UC; Smith, LA | 1 |
| Anthes, J; Billah, M; Brown, JE; Cheewatrakoolpong, B; Egan, RW; Greenfeder, S; Murgolo, NJ | 1 |
| Belmonte, KE; Costello, RW; Fryer, AD; Jacoby, DB | 1 |
| Inoue, M; Katsuyama, S; Kisara, K; Sakurada, C; Sakurada, S; Sakurada, T; Sasaki, J; Tan-No, K; Ueda, H | 1 |
| Compernolle, F; De Wit, T; Hoornaert, GJ; Van Emelen, K | 1 |
| Blier, P; Haddjeri, N | 1 |
Other Studies
16 other study(ies) available for cp 96345 and cp 99994
| Article | Year |
|---|---|
Discovery of a potent substance P antagonist: recognition of the key molecular determinant.
Topics: Humans; Models, Molecular; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Stereoisomerism; Substance P | 1992 |
Synthesis and biological evaluation of NK1 antagonists derived from L-tryptophan.
Topics: Amines; Amino Acid Sequence; Animals; Binding Sites; Biphenyl Compounds; Cardiovascular System; CHO Cells; Cricetinae; Esters; Extravasation of Diagnostic and Therapeutic Materials; Female; Ferrets; Guinea Pigs; Heterocyclic Compounds; Humans; Hypnotics and Sedatives; Male; Molecular Sequence Data; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Solubility; Structure-Activity Relationship; Substance P; Tryptophan | 1995 |
2(S)-((3,5-bis(trifluoromethyl)benzyl)-oxy)-3(S)-phenyl-4- ((3-oxo-1,2,4-triazol-5-yl)methyl)morpholine (1): a potent, orally active, morpholine-based human neurokinin-1 receptor antagonist.
Topics: Administration, Oral; Animals; CHO Cells; Cricetinae; Humans; Morpholines; Neurokinin-1 Receptor Antagonists | 1996 |
Derivation of a three-dimensional pharmacophore model of substance P antagonists bound to the neurokinin-1 receptor.
Topics: Binding Sites; Biphenyl Compounds; Crystallography, X-Ray; Ligands; Models, Molecular; Molecular Conformation; Neurokinin-1 Receptor Antagonists; Receptors, Neurokinin-1; Structure-Activity Relationship; Substance P | 1998 |
Differences in the effects of NK1-receptor antagonists, (+/-)-CP 96,345 and CP 99,994, on agonist-induced responses in guinea-pig trachea.
Topics: Animals; Biphenyl Compounds; Guinea Pigs; In Vitro Techniques; Indoles; Isoindoles; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Substance P; Trachea | 1994 |
Effect of the tachykinin NK1 receptor antagonists, RP 67580 and SR 140333, on electrically-evoked substance P release from rat spinal cord.
Topics: Amino Acid Sequence; Analgesics; Animals; Biphenyl Compounds; Calcitonin Gene-Related Peptide; Electric Stimulation; Hypnotics and Sedatives; In Vitro Techniques; Indoles; Isoindoles; Male; Molecular Sequence Data; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Spinal Cord; Substance P | 1994 |
Antagonism of nociceptive responses of cat spinal dorsal horn neurons in vivo by the NK-1 receptor antagonists CP-96,345 and CP-99,994, but not by CP-96,344.
Topics: Animals; Biphenyl Compounds; Cats; Hot Temperature; Hypnotics and Sedatives; Membrane Potentials; Neurokinin-1 Receptor Antagonists; Nociceptors; Piperidines; Spinal Cord; Spinal Nerve Roots; Substance P | 1995 |
Tachykinin receptors mediating contraction of guinea pig lung strips.
Topics: Acetylcholine; Animals; Benzamides; Biphenyl Compounds; Dipeptides; Guinea Pigs; In Vitro Techniques; Lung; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Tachykinin; Substance P; Trachea | 1995 |
Neurokinin receptors in the guinea pig ileum.
Topics: Acetylcholine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Biphenyl Compounds; Guinea Pigs; Ileum; Male; Myenteric Plexus; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Radioligand Assay; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Stereoisomerism; Structure-Activity Relationship; Substance P | 1996 |
Bradykinin-mediated activation of renal sensory neurons due to prostaglandin-dependent release of substance P.
Topics: Animals; Biphenyl Compounds; Bradykinin; Indoles; Indomethacin; Isoindoles; Kidney; Male; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Piperidines; Prostaglandins; Prostaglandins E; Rats; Rats, Sprague-Dawley; Substance P | 1997 |
Electrophysiological evidence that neurokinin A acts via NK-1 receptors in the cat dorsal horn.
Topics: Animals; Benzamides; Biphenyl Compounds; Cats; Iontophoresis; Neurokinin A; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Spinal Cord; Stereoisomerism; Substance P; Synapses | 1997 |
Two related neurokinin-1 receptor antagonists have overlapping but different binding sites.
Topics: Animals; Binding Sites; Biphenyl Compounds; COS Cells; Humans; Hypnotics and Sedatives; Models, Chemical; Mutagenesis, Site-Directed; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Stereoisomerism; Substance P | 1998 |
Effects of tachykinin NK1 receptor antagonists on vagal hyperreactivity and neuronal M2 muscarinic receptor function in antigen challenged guinea-pigs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Electric Stimulation; Eosinophilia; Guinea Pigs; Lung; Neurokinin A; Neurokinin-1 Receptor Antagonists; Ovalbumin; Peptide Fragments; Pilocarpine; Piperidines; Quinuclidines; Receptor, Muscarinic M2; Receptors, Muscarinic; Receptors, Tachykinin; Specific Pathogen-Free Organisms; Substance P; Trachea; Vagus Nerve | 1998 |
Nociceptin-induced scratching, biting and licking in mice: involvement of spinal NK1 receptors.
Topics: Aggression; Analgesics, Opioid; Animals; Antibodies, Blocking; Behavior, Animal; Biphenyl Compounds; Dose-Response Relationship, Drug; Injections, Spinal; Male; Mice; Morphine; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neurons; Nociceptin; Opioid Peptides; Piperidines; Receptors, Neurokinin-1; Receptors, Opioid; Spinal Cord; Substance P | 1999 |
Diastereoselective intramolecular Ritter reaction: generation of a cis-fused hexahydro-4aH-indeno[1,2-b]pyridine ring system with 4a,9b-diangular substituents.
Topics: Biphenyl Compounds; Chromatography, Thin Layer; Crystallography, X-Ray; Cyclization; Magnetic Resonance Spectroscopy; Molecular Structure; Neurokinin-1 Receptor Antagonists; Piperidines; Pyridines; Receptors, Neurokinin-1; Stereoisomerism; Substance P | 2000 |
Neurokinin-1 receptor antagonists modulate brain noradrenaline and serotonin interactions.
Topics: Adrenergic alpha-Agonists; Animals; Biphenyl Compounds; Clonidine; Drug Administration Schedule; Electrophysiology; Hypnotics and Sedatives; Locus Coeruleus; Male; Neurokinin-1 Receptor Antagonists; Neurons; Norepinephrine; Piperidines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Serotonin | 2008 |