cp 424391 has been researched along with piperidines in 28 studies
| Studies (cp 424391) | Trials (cp 424391) | Recent Studies (post-2010) (cp 424391) | Studies (piperidines) | Trials (piperidines) | Recent Studies (post-2010) (piperidines) |
|---|---|---|---|---|---|
| 34 | 7 | 20 | 40,235 | 5,221 | 14,545 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (35.71) | 29.6817 |
| 2010's | 14 (50.00) | 24.3611 |
| 2020's | 4 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Ding, C; Gay, DM; Hendrick, JW; King, MK; McElmurray, JH; Morrison, A; Mukherjee, R; Pan, LC; Pirie, C; Spinale, FG | 1 |
| Carpino, PA; Chidsey-Frink, K; DaSilva-Jardine, PA; Lefker, BA; Lu, B; MacLean, DB; Mullins, MA; Nettleton, DO; Ng, O; Nickerson, DF; Pan, LC; Pettersen, JC; Pirie, CM; Ragan, JA; Tess, DA; Thompson, DD; Toler, SM | 1 |
| Black, SC; Ellery, SS; MacAndrew, JT; Pan, LC; Parry, MA | 1 |
| Carpino, PA; Chidsey-Frink, KL; Cook, ER; DaSilva-Jardine, PA; DeNinno, SL; DiBrino, JN; Hada, WA; Hadcock, JR; Inthavongsay, J; Lefker, BA; Lewis, SK; Mangano, FM; Mullins, MA; Murray, MC; Ng, O; Nickerson, DF; Pan, LC; Pettersen, JC; Pirie, CM; Ragan, JA; Rose, CR; Tess, DA; Thompson, DD; Toler, SM; Wilson, TC; Wright, AS; Yu, L; Zawistoski, MP | 1 |
| Campeta, AM; Carpino, PA; Chidsey-Frink, KL; Cook, ER; DaSilva-Jardine, PA; DeNinno, SL; DiBrino, JN; Hada, WA; Hadcock, JR; Inthavongsay, J; Lefker, BA; Mangano, FM; Mullins, MA; Ng, O; Nickerson, DF; Pan, LC; Pirie, CM; Ragan, JA; Rose, CR; Tess, DA; Thompson, DD; Toler, SM; Wilson, TC; Wright, AS; Yu, L; Zawistoski, MP | 1 |
| Fouda, HG; Khojasteh-Bakht, SC; O'donnell, JP; Potchoiba, MJ | 1 |
| De Smet, B; Depoortere, I; Kitazawa, T; Peeters, TL; Verbeke, K | 1 |
| Hersch, EC; Merriam, GR | 1 |
| Blackman, MR; Ettinger, MP; Hoffman, AR; Landschulz, W; Lyles, K; MacLean, D; Merriam, GR; Morey, MC; Petrie, CD; Salvatori, R; Taylor, A; Wei, JY; White, HK | 1 |
| Cossy, J; Lacheretz, R; Pardo, DG | 1 |
| Brock, JA; Bron, R; Ferens, DM; Furness, JB; Gale, JD; Habgood, M; Ohashi-Doi, K; Yin, L | 1 |
| Brock, JA; Brown, DJ; Ferens, DM; Furness, JB; Habgood, MD; Saunders, NR; Tan, YH | 1 |
| Aerssens, J; Aourz, N; Bortolotto, ZA; Clinckers, R; Collingridge, GL; Coppens, J; Loyens, E; Michotte, Y; Moechars, D; Portelli, J; Schallier, A; Smolders, I; Thielemans, L; Ver Donck, L; Vermoesen, K | 1 |
| Abogadie, FC; Baell, J; Ban, K; Brock, JA; Callaghan, B; Ferens, D; Furness, JB; Hirayama, H; Hunne, B; McIntyre, P; Nguyen, TV; Sartor, DM | 1 |
| Baell, J; Ban, K; Brock, JA; Callaghan, B; Ferens, D; Furness, JB; Kosari, S; Nguyen, TV; Pustovit, RV; Rivera, LR; Sartor, DM | 1 |
| Andrews, ZB; Au, CC; Brown, KA; Callaghan, B; Docanto, MM; Furness, JB; Ragavan, R; Wang, X; Yang, F | 1 |
| Brown, DJ; Ellis, AG; Frauman, AG; Furness, JB; Millard, M; Zeglinski, PT | 1 |
| Furness, JB; Pustovit, RV; Rivera, LR | 1 |
| Rhodes, L; Smith, RG; Zollers, B | 1 |
| Armintrout, G; Huebner, M; Rausch-Derra, LC; Rhodes, L; Zollers, B | 1 |
| Heinen, E; Huebner, M; Rhodes, L; Wofford, JA; Zollers, B | 1 |
| Carpino, PA; Lefker, BA; Mangano, FM; Rose, CR; Wright, AS; Zawistoski, MP | 1 |
| Heinen, E; Rhodes, L; Zollers, B | 1 |
| Bell, M; Heinen, E; Rhodes, L; Wofford, JA; Zollers, B | 1 |
| Crakes, KR; Gilor, C; Greathouse, RL; Huising, MO; Miller, M; Pires, J; Quach, N | 1 |
| Bidlingmaier, M; Delahaut, P; Fichant, E; Görgens, C; Lange, T; Schilbach, K; Thevis, M; Thomas, A | 1 |
| Ceron-Romero, N; Heinen, E; Sanmartin, K; Taofeek, N; Thomas, A; Verghese, M; Vizcarra, JA; Vroonland, E | 1 |
| Castro, RA; Gilor, C; Hill, RC; O'Kell, AL; Pascutti, KM; Salute, ME | 1 |
1 review(s) available for cp 424391 and piperidines
| Article | Year |
|---|---|
Growth hormone (GH)-releasing hormone and GH secretagogues in normal aging: Fountain of Youth or Pool of Tantalus?
Topics: Aged; Aging; Atrophy; Cognition; Frail Elderly; Growth Hormone; Growth Hormone-Releasing Hormone; Humans; Injections; Muscle, Skeletal; Neurotransmitter Agents; Piperidines; Pyrazoles | 2008 |
7 trial(s) available for cp 424391 and piperidines
| Article | Year |
|---|---|
Effects of an oral growth hormone secretagogue in older adults.
Topics: Administration, Oral; Aged; Aged, 80 and over; Body Composition; Double-Blind Method; Female; Health Status; Human Growth Hormone; Humans; Insulin-Like Growth Factor I; Male; Piperidines; Placebos; Pyrazoles; Safety | 2009 |
Pharmacokinetics of the ghrelin agonist capromorelin in a single ascending dose Phase-I safety trial in spinal cord-injured and able-bodied volunteers.
Topics: Administration, Oral; Adult; Area Under Curve; Autonomic Agents; Blood Pressure; Dose-Response Relationship, Drug; Follow-Up Studies; Ghrelin; Half-Life; Humans; Male; Piperidines; Pyrazoles; Spinal Cord Injuries; Victoria | 2015 |
Capromorelin increases food consumption, body weight, growth hormone, and sustained insulin-like growth factor 1 concentrations when administered to healthy adult Beagle dogs.
Topics: Animals; Body Weight; Dogs; Dose-Response Relationship, Drug; Eating; Growth Hormone; Hydrocortisone; Insulin-Like Growth Factor I; Piperidines; Pyrazoles | 2017 |
A Prospective, Randomized, Masked, Placebo-Controlled Clinical Study of Capromorelin in Dogs with Reduced Appetite.
Topics: Animals; Appetite; Appetite Stimulants; Body Weight; Dogs; Female; Male; Piperidines; Prospective Studies; Pyrazoles; Receptors, Ghrelin | 2016 |
Capromorelin oral solution (ENTYCE®) increases food consumption and body weight when administered for 4 consecutive days to healthy adult Beagle dogs in a randomized, masked, placebo controlled study.
Topics: Animals; Appetite Stimulants; Body Weight; Cross-Over Studies; Dogs; Eating; Female; Male; Piperidines; Pyrazoles | 2017 |
Evaluation of the safety of daily administration of capromorelin in cats.
Topics: Administration, Oral; Animals; Cat Diseases; Cats; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Growth Hormone; Insulin-Like Growth Factor I; Lethargy; Male; Piperidines; Pyrazoles; Sialorrhea; Vomiting | 2018 |
Capromorelin, a ghrelin receptor agonist, increases feed intake and body weight gain in broiler chickens (Gallus gallus domesticus).
Topics: Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Body Weight; Chickens; Diet; Eating; Male; Piperidines; Pyrazoles; Receptors, Ghrelin; Weight Gain | 2021 |
20 other study(ies) available for cp 424391 and piperidines
| Article | Year |
|---|---|
Treatment with a growth hormone secretagogue in a model of developing heart failure: effects on ventricular and myocyte function.
Topics: Animals; Cardiac Pacing, Artificial; Echocardiography; Growth Hormone; Heart Failure; Male; Myocardial Contraction; Myocytes, Cardiac; Piperidines; Pyrazoles; Swine; Ventricular Function | 2001 |
Preclinical pharmacology of CP-424,391, an orally active pyrazolinone-piperidine [correction of pyrazolidinone-piperidine] growth hormone secretagogue.
Topics: Administration, Oral; Adrenocorticotropic Hormone; Animals; Body Weight; Calcium; Cells, Cultured; Dogs; Female; Growth Hormone; Growth Hormone-Releasing Hormone; Hydrocortisone; Models, Animal; Molecular Structure; Oligopeptides; Peptides; Piperidines; Pituitary Gland, Anterior; Pyrazoles; Rats; Rats, Sprague-Dawley; Rats, Wistar; Somatostatin; Time Factors | 2001 |
Efficacy of a growth hormone-releasing peptide mimetic in cardiac ischemia/reperfusion injury.
Topics: Animals; Body Weight; Dose-Response Relationship, Drug; Growth Hormone; Heart Ventricles; Hemodynamics; Insulin-Like Growth Factor I; Male; Myocardial Infarction; Piperidines; Pyrazoles; Rabbits; Reperfusion Injury; Time Factors; Treatment Outcome | 2001 |
Discovery and biological characterization of capromorelin analogues with extended half-lives.
Topics: Administration, Oral; Animals; Biological Availability; Dogs; Growth Hormone; Growth Substances; Half-Life; Hydrophobic and Hydrophilic Interactions; Insulin-Like Growth Factor I; Male; Piperidines; Pyrazoles; Rats; Rats, Wistar; Structure-Activity Relationship | 2002 |
Pyrazolinone-piperidine dipeptide growth hormone secretagogues (GHSs). Discovery of capromorelin.
Topics: Animals; Cells, Cultured; Chemical Phenomena; Chemistry, Physical; Dipeptides; DNA, Complementary; Dogs; Drug Design; Female; Growth Hormone; Half-Life; Humans; Indicators and Reagents; Indoles; Magnetic Resonance Spectroscopy; Piperidines; Pituitary Gland; Pyrazoles; Rats; Rats, Sprague-Dawley; Rats, Wistar; Solubility; Spiro Compounds | 2003 |
Metabolism, pharmacokinetics, tissue distribution, and excretion of [14C]CP-424391 in rats.
Topics: Administration, Oral; Animals; Carbon Radioisotopes; Feces; Female; Growth Substances; Male; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Tissue Distribution | 2005 |
Gastric motor effects of peptide and non-peptide ghrelin agonists in mice in vivo and in vitro.
Topics: Animals; Atropine; Bethanechol; Breath Tests; Cholinergic Agents; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gastric Emptying; Ghrelin; Growth Hormone-Releasing Hormone; Male; Mice; Mice, Inbred Strains; Muscle Contraction; NG-Nitroarginine Methyl Ester; Oligopeptides; Peptide Hormones; Piperidines; Pyrazoles; Stomach | 2005 |
Daucus carota mediated-reduction of cyclic 3-oxo-amines.
Topics: Amines; Daucus carota; Ketones; Molecular Structure; Oxidation-Reduction; Piperidines; Pyrazoles; Stereoisomerism | 2009 |
Evidence for functional ghrelin receptors on parasympathetic preganglionic neurons of micturition control pathways in the rat.
Topics: Animals; Autonomic Fibers, Preganglionic; Gene Expression; Male; Piperidines; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Ghrelin; Reflex; Spinal Cord; Spinal Cord Injuries; Urinary Bladder; Urination | 2010 |
Stimulation of defecation in spinal cord-injured rats by a centrally acting ghrelin receptor agonist.
Topics: Animals; Constipation; Defecation; Disease Models, Animal; Growth Hormone; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Ghrelin; Spinal Cord Injuries | 2011 |
Inactivation of the constitutively active ghrelin receptor attenuates limbic seizure activity in rodents.
Topics: Analysis of Variance; Animals; Anticonvulsants; Calcium; Disease Models, Animal; Disease Susceptibility; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Ghrelin; Green Fluorescent Proteins; HEK293 Cells; Hippocampus; Humans; In Vitro Techniques; Limbic System; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Muscarinic Agonists; Neurons; Patch-Clamp Techniques; Pilocarpine; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Ghrelin; Seizures; Severity of Illness Index; Species Specificity; Transfection | 2012 |
Sites of action of ghrelin receptor ligands in cardiovascular control.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Cardiovascular System; Ganglia, Sympathetic; Ghrelin; Green Fluorescent Proteins; HEK293 Cells; Humans; Ligands; Male; Mesenteric Arteries; Mice; Mice, Inbred C57BL; Mice, Transgenic; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Ghrelin; RNA, Messenger; Vasodilation | 2012 |
Hypotensive effects of ghrelin receptor agonists mediated through a novel receptor.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Ghrelin; HEK293 Cells; Humans; Hypotension; In Vitro Techniques; Macrocyclic Compounds; Male; Mesenteric Arteries; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Ghrelin | 2014 |
Ghrelin and des-acyl ghrelin inhibit aromatase expression and activity in human adipose stromal cells: suppression of cAMP as a possible mechanism.
Topics: Adipose Tissue; Aromatase; Blotting, Western; Breast; Calcium; Cells, Cultured; Cyclic AMP; Female; Ghrelin; Humans; Piperidines; Pyrazoles; Real-Time Polymerase Chain Reaction; Receptors, Ghrelin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stromal Cells | 2014 |
A ghrelin receptor agonist is an effective colokinetic in rats with diet-induced constipation.
Topics: Animals; Colon; Constipation; Defecation; Dietary Fiber; Gastrointestinal Motility; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Ghrelin; Rectum | 2015 |
Evaluation of the safety in dogs of long-term, daily oral administration of capromorelin, a novel drug for stimulation of appetite.
Topics: Administration, Oral; Animals; Appetite; Appetite Stimulants; Dogs; Piperidines; Pyrazoles | 2017 |
Practical synthesis of capromorelin, a growth hormone secretagogue, via a crystallization-induced dynamic resolution.
Topics: Crystallography, X-Ray; Models, Molecular; Molecular Structure; Piperidines; Pyrazoles; Thermodynamics | 2017 |
The effect of the ghrelin-receptor agonist capromorelin on glucose metabolism in healthy cats.
Topics: Animals; Blood Glucose; Cats; Glucagon; Glucose; Glucose Tolerance Test; Insulin; Insulin Resistance; Male; Piperidines; Pyrazoles; Receptors, Ghrelin | 2021 |
Comprehensive insights into the formation of metabolites of the ghrelin mimetics capromorelin, macimorelin and tabimorelin as potential markers for doping control purposes.
Topics: Animals; Biomarkers; Chromatography, Liquid; Dipeptides; Doping in Sports; Female; Ghrelin; Humans; Indoles; Limit of Detection; Male; Piperidines; Pyrazoles; Rats; Reproducibility of Results; Solid Phase Extraction; Tandem Mass Spectrometry; Tryptophan | 2021 |
The effect of capromorelin on glycemic control in healthy dogs.
Topics: Animals; Blood Glucose; Blood Glucose Self-Monitoring; Cats; Dogs; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Glycemic Control; Insulin; Piperidines; Prospective Studies; Pyrazoles | 2022 |