cp 122288 has been researched along with sumatriptan in 15 studies
| Studies (cp 122288) | Trials (cp 122288) | Recent Studies (post-2010) (cp 122288) | Studies (sumatriptan) | Trials (sumatriptan) | Recent Studies (post-2010) (sumatriptan) |
|---|---|---|---|---|---|
| 17 | 1 | 0 | 2,405 | 461 | 480 |
| Protein | Taxonomy | cp 122288 (IC50) | sumatriptan (IC50) |
|---|---|---|---|
| 5-hydroxytryptamine receptor 3E | Homo sapiens (human) | 0.0073 | |
| 5-hydroxytryptamine receptor 3B | Homo sapiens (human) | 0.0073 | |
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | 0.4497 | |
| Carboxypeptidase M | Homo sapiens (human) | 0.02 | |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | 0.64 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 0.722 | |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | 0.64 | |
| 5-hydroxytryptamine receptor 1D | Homo sapiens (human) | 0.3091 | |
| 5-hydroxytryptamine receptor 1B | Homo sapiens (human) | 0.0131 | |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | 7.9433 | |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | 3.9753 | |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | 0.804 | |
| 5-hydroxytryptamine receptor 1D | Rattus norvegicus (Norway rat) | 0.061 | |
| 5-hydroxytryptamine receptor 1E | Homo sapiens (human) | 5.5 | |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | 0.64 | |
| 5-hydroxytryptamine receptor 3A | Homo sapiens (human) | 0.0078 | |
| 5-hydroxytryptamine receptor 5A | Homo sapiens (human) | 0.5012 | |
| 5-hydroxytryptamine receptor 1D | Sus scrofa (pig) | 0.02 | |
| 5-hydroxytryptamine receptor 1A | Mus musculus (house mouse) | 0.45 | |
| 5-hydroxytryptamine receptor 3D | Homo sapiens (human) | 0.0073 | |
| 5-hydroxytryptamine receptor 3C | Homo sapiens (human) | 0.0073 | |
| Multidrug and toxin extrusion protein 1 | Homo sapiens (human) | 6.7 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (73.33) | 18.2507 |
| 2000's | 4 (26.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barrett, V; Brockwell, M; Cambridge, D; Farrant, DR; Foster, C; Giles, H; Glen, RC; Hill, AP; Hobbs, H; Honey, A; Jandu, KS; Martin, GR; Salmon, J; Selwood, DL; Smith, D; Woollard, P | 1 |
| Beattie, DT; Connor, HE | 1 |
| Brain, SD; Gupta, P; Kajekar, R; Shepperson, NB | 1 |
| Cutrer, FM; Limmroth, V; Moskowitz, MA; Panahian, N; Schoenfeld, D | 1 |
| Lee, WS; Moskowitz, MA | 1 |
| Brown, D; Butler, P; Ellis, P; Grayson, KL; Gupta, P; Land, GC; Macor, JE; Robson, SF; Shepperson, NB; Wythes, MJ | 1 |
| Moskowitz, MA; Waeber, C | 1 |
| Castanon, N; Chauveau, J; Chaveau, J; Hen, R; Macor, JE; Moskowitz, MA; Scearce, K; Waeber, C; Yu, XJ | 1 |
| Cutrer, FM; Moskowitz, MA; Waeber, C; Yu, XJ | 1 |
| Johnson, KW; Phebus, LA | 1 |
| Goadsby, PJ; Hoskin, KL | 1 |
| Edvinsson, L; Goadsby, PJ; Knight, YE | 1 |
| Christianssen, I; Diener, HC; Ellis, P; Ferrari, MD; Hettiarachchi, J; Kleinermans, D; Kok, JG; Olesen, J; Poole, PH; Roon, KI | 1 |
| Lunte, CE; Saunders, K; Weiss, DJ | 1 |
| Hargreaves, RJ; Williamson, DJ | 1 |
1 review(s) available for cp 122288 and sumatriptan
| Article | Year |
|---|---|
Neurogenic inflammation in the context of migraine.
Topics: Animals; Blood Proteins; Bosentan; Calcitonin Gene-Related Peptide; Capillary Permeability; Dihydroergotamine; Dura Mater; Humans; Migraine Disorders; Narcotics; Neurogenic Inflammation; Neurokinin-1 Receptor Antagonists; Pyrrolidines; Receptor, Serotonin, 5-HT1D; Receptor, Serotonin, 5-HT1F; Receptors, Neurokinin-1; Receptors, Serotonin; Serotonin Receptor Agonists; Skull; Sulfonamides; Sumatriptan; Trigeminal Nerve; Vasoconstrictor Agents; Vasodilation | 2001 |
1 trial(s) available for cp 122288 and sumatriptan
| Article | Year |
|---|---|
No acute antimigraine efficacy of CP-122,288, a highly potent inhibitor of neurogenic inflammation: results of two randomized, double-blind, placebo-controlled clinical trials.
Topics: Administration, Oral; Adolescent; Adult; Aged; Cross-Over Studies; Double-Blind Method; Female; Humans; Injections, Intravenous; Male; Middle Aged; Migraine Disorders; Neurogenic Inflammation; Placebos; Pyrrolidines; Serotonin Receptor Agonists; Sumatriptan; Treatment Failure | 2000 |
13 other study(ies) available for cp 122288 and sumatriptan
| Article | Year |
|---|---|
Discovery of 4-[3-(trans-3-dimethylaminocyclobutyl)-1H-indol-5-ylmethyl]-(4S)-oxazolidin-2-one (4991W93), a 5HT(1B/1D) receptor partial agonist and a potent inhibitor of electrically induced plasma extravasation.
Topics: Administration, Oral; Animals; Binding, Competitive; Biological Availability; Brain; Capillary Permeability; Cattle; CHO Cells; Cricetinae; Ear; Electric Stimulation; Guinea Pigs; Humans; In Vitro Techniques; Indoles; Male; Migraine Disorders; Models, Molecular; Oxazoles; Rabbits; Rats; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Regional Blood Flow; Serotonin Receptor Agonists; Serum Albumin, Bovine; Structure-Activity Relationship; Trigeminal Ganglion; Vasoconstrictor Agents | 2001 |
The pre- and postjunctional activity of CP-122,288, a conformationally restricted analogue of sumatriptan.
Topics: Animals; Basilar Artery; Blood Proteins; Capillary Permeability; Cell Line; Dogs; Dura Mater; Female; Haplorhini; Humans; In Vitro Techniques; Male; Molecular Conformation; Muscle Contraction; Muscle, Smooth, Vascular; Neuromuscular Junction; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Saphenous Vein; Sumatriptan | 1995 |
Effect of a 5-HT1 receptor agonist, CP-122,288, on oedema formation induced by stimulation of the rat saphenous nerve.
Topics: Analysis of Variance; Animals; Edema; Electric Stimulation; Male; Neuritis; Neurons, Afferent; Pyridines; Pyrroles; Pyrrolidines; Rats; Rats, Wistar; Serotonin Receptor Agonists; Sumatriptan | 1995 |
Suppression by the sumatriptan analogue, CP-122,288 of c-fos immunoreactivity in trigeminal nucleus caudalis induced by intracisternal capsaicin.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Capsaicin; Cisterna Magna; Depression, Chemical; Guinea Pigs; Heart Rate; Immunohistochemistry; In Vitro Techniques; Injections; Male; Nociceptors; Proto-Oncogene Proteins c-fos; Pyrrolidines; Respiratory Mechanics; Sumatriptan; Trigeminal Ganglion | 1995 |
Conformationally restricted sumatriptan analogues, CP-122,288 and CP-122,638 exhibit enhanced potency against neurogenic inflammation in dura mater.
Topics: Animals; Dura Mater; Electric Stimulation; Guinea Pigs; Male; Meningitis; Molecular Conformation; Pyrrolidines; Sumatriptan; Trigeminal Ganglion | 1993 |
The in vivo pharmacological profile of a 5-HT1 receptor agonist, CP-122,288, a selective inhibitor of neurogenic inflammation.
Topics: Anesthesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capillary Permeability; Dogs; Dose-Response Relationship, Drug; Dura Mater; Electric Stimulation; Hemodynamics; Inflammation; Male; Pyrrolidines; Rats; Rats, Sprague-Dawley; Serotonin Receptor Agonists; Species Specificity; Sumatriptan; Trigeminal Ganglion; Vasoconstriction | 1995 |
[3H]sumatriptan labels both 5-HT1D and 5-HT1F receptor binding sites in the guinea pig brain: an autoradiographic study.
Topics: Animals; Autoradiography; Binding, Competitive; Brain; Guinea Pigs; Iodine Radioisotopes; Isotope Labeling; Male; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin Receptor Agonists; Sumatriptan; Tissue Distribution | 1995 |
5-Carboxamido-tryptamine, CP-122,288 and dihydroergotamine but not sumatriptan, CP-93,129, and serotonin-5-O-carboxymethyl-glycyl -tyrosinamide block dural plasma protein extravasation in knockout mice that lack 5-hydroxytryptamine1B receptors.
Topics: Animals; Capillary Permeability; Dihydroergotamine; Dipeptides; Mice; Mice, Knockout; Pyridines; Pyrroles; Pyrrolidines; Receptors, Serotonin; Serotonin; Serotonin Receptor Agonists; Sumatriptan; Trigeminal Ganglion | 1996 |
The 5-HT1D receptor antagonist GR-127,935 prevents inhibitory effects of sumatriptan but not CP-122,288 and 5-CT on neurogenic plasma extravasation within guinea pig dura mater.
Topics: Animals; Dose-Response Relationship, Drug; Dura Mater; Electric Stimulation; Female; Guinea Pigs; Male; Oxadiazoles; Pertussis Toxin; Piperazines; Prosencephalon; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Sumatriptan; Trigeminal Nerve; Virulence Factors, Bordetella | 1997 |
A fluorescence-based method for assessing dural protein extravasation induced by trigeminal ganglion stimulation.
Topics: Animals; Biological Transport; Dura Mater; Electric Stimulation; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; Fluorescence; Guinea Pigs; Inflammation; Injections, Intravenous; Male; Microscopy, Fluorescence; Microspectrophotometry; Migraine Disorders; Protein Binding; Proteins; Pyrrolidines; Sumatriptan; Trigeminal Ganglion | 1998 |
Differential effects of low dose CP122,288 and eletriptan on fos expression due to stimulation of the superior sagittal sinus in cat.
Topics: Animals; Cats; Cranial Sinuses; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Indoles; Neurons; Proto-Oncogene Proteins c-fos; Pyrrolidines; Serotonin Receptor Agonists; Stimulation, Chemical; Sumatriptan; Trigeminal Neuralgia; Tryptamines; Vasoconstrictor Agents | 1999 |
Blockade of calcitonin gene-related peptide release after superior sagittal sinus stimulation in cat: a comparison of avitriptan and CP122,288.
Topics: Animals; Calcitonin Gene-Related Peptide; Cats; Cerebral Arteries; Cerebrovascular Circulation; Cranial Sinuses; Electric Stimulation; Indoles; Jugular Veins; Migraine Disorders; Pyrrolidines; Serotonin Receptor Agonists; Sulfonamides; Sumatriptan; Trigeminal Nerve; Tryptamines | 1999 |
pH-mediated field-amplified sample stacking of pharmaceutical cations in high-ionic strength samples.
Topics: Cations; Doxazosin; Electrophoresis, Capillary; Hydrogen-Ion Concentration; Indoles; Isotonic Solutions; Osmolar Concentration; Phenethylamines; Piperazines; Purines; Pyrimidinones; Pyrrolidines; Ringer's Solution; Sildenafil Citrate; Sulfonamides; Sulfones; Sumatriptan; Tryptamines | 2001 |