Page last updated: 2024-09-03

cp 122288 and sumatriptan

cp 122288 has been researched along with sumatriptan in 15 studies

Compound Research Comparison

Studies
(cp 122288)
Trials
(cp 122288)
Recent Studies (post-2010)
(cp 122288)
Studies
(sumatriptan)
Trials
(sumatriptan)
Recent Studies (post-2010) (sumatriptan)
17102,405461480

Protein Interaction Comparison

ProteinTaxonomycp 122288 (IC50)sumatriptan (IC50)
5-hydroxytryptamine receptor 3EHomo sapiens (human)0.0073
5-hydroxytryptamine receptor 3BHomo sapiens (human)0.0073
5-hydroxytryptamine receptor 1AHomo sapiens (human)0.4497
Carboxypeptidase MHomo sapiens (human)0.02
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)0.64
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)0.722
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)0.64
5-hydroxytryptamine receptor 1DHomo sapiens (human)0.3091
5-hydroxytryptamine receptor 1BHomo sapiens (human)0.0131
5-hydroxytryptamine receptor 2AHomo sapiens (human)7.9433
5-hydroxytryptamine receptor 2CHomo sapiens (human)3.9753
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)0.804
5-hydroxytryptamine receptor 1DRattus norvegicus (Norway rat)0.061
5-hydroxytryptamine receptor 1EHomo sapiens (human)5.5
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)0.64
5-hydroxytryptamine receptor 3AHomo sapiens (human)0.0078
5-hydroxytryptamine receptor 5AHomo sapiens (human)0.5012
5-hydroxytryptamine receptor 1DSus scrofa (pig)0.02
5-hydroxytryptamine receptor 1AMus musculus (house mouse)0.45
5-hydroxytryptamine receptor 3DHomo sapiens (human)0.0073
5-hydroxytryptamine receptor 3CHomo sapiens (human)0.0073
Multidrug and toxin extrusion protein 1Homo sapiens (human)6.7

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's11 (73.33)18.2507
2000's4 (26.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barrett, V; Brockwell, M; Cambridge, D; Farrant, DR; Foster, C; Giles, H; Glen, RC; Hill, AP; Hobbs, H; Honey, A; Jandu, KS; Martin, GR; Salmon, J; Selwood, DL; Smith, D; Woollard, P1
Beattie, DT; Connor, HE1
Brain, SD; Gupta, P; Kajekar, R; Shepperson, NB1
Cutrer, FM; Limmroth, V; Moskowitz, MA; Panahian, N; Schoenfeld, D1
Lee, WS; Moskowitz, MA1
Brown, D; Butler, P; Ellis, P; Grayson, KL; Gupta, P; Land, GC; Macor, JE; Robson, SF; Shepperson, NB; Wythes, MJ1
Moskowitz, MA; Waeber, C1
Castanon, N; Chauveau, J; Chaveau, J; Hen, R; Macor, JE; Moskowitz, MA; Scearce, K; Waeber, C; Yu, XJ1
Cutrer, FM; Moskowitz, MA; Waeber, C; Yu, XJ1
Johnson, KW; Phebus, LA1
Goadsby, PJ; Hoskin, KL1
Edvinsson, L; Goadsby, PJ; Knight, YE1
Christianssen, I; Diener, HC; Ellis, P; Ferrari, MD; Hettiarachchi, J; Kleinermans, D; Kok, JG; Olesen, J; Poole, PH; Roon, KI1
Lunte, CE; Saunders, K; Weiss, DJ1
Hargreaves, RJ; Williamson, DJ1

Reviews

1 review(s) available for cp 122288 and sumatriptan

ArticleYear
Neurogenic inflammation in the context of migraine.
    Microscopy research and technique, 2001, May-01, Volume: 53, Issue:3

    Topics: Animals; Blood Proteins; Bosentan; Calcitonin Gene-Related Peptide; Capillary Permeability; Dihydroergotamine; Dura Mater; Humans; Migraine Disorders; Narcotics; Neurogenic Inflammation; Neurokinin-1 Receptor Antagonists; Pyrrolidines; Receptor, Serotonin, 5-HT1D; Receptor, Serotonin, 5-HT1F; Receptors, Neurokinin-1; Receptors, Serotonin; Serotonin Receptor Agonists; Skull; Sulfonamides; Sumatriptan; Trigeminal Nerve; Vasoconstrictor Agents; Vasodilation

2001

Trials

1 trial(s) available for cp 122288 and sumatriptan

ArticleYear
No acute antimigraine efficacy of CP-122,288, a highly potent inhibitor of neurogenic inflammation: results of two randomized, double-blind, placebo-controlled clinical trials.
    Annals of neurology, 2000, Volume: 47, Issue:2

    Topics: Administration, Oral; Adolescent; Adult; Aged; Cross-Over Studies; Double-Blind Method; Female; Humans; Injections, Intravenous; Male; Middle Aged; Migraine Disorders; Neurogenic Inflammation; Placebos; Pyrrolidines; Serotonin Receptor Agonists; Sumatriptan; Treatment Failure

2000

Other Studies

13 other study(ies) available for cp 122288 and sumatriptan

ArticleYear
Discovery of 4-[3-(trans-3-dimethylaminocyclobutyl)-1H-indol-5-ylmethyl]-(4S)-oxazolidin-2-one (4991W93), a 5HT(1B/1D) receptor partial agonist and a potent inhibitor of electrically induced plasma extravasation.
    Journal of medicinal chemistry, 2001, Mar-01, Volume: 44, Issue:5

    Topics: Administration, Oral; Animals; Binding, Competitive; Biological Availability; Brain; Capillary Permeability; Cattle; CHO Cells; Cricetinae; Ear; Electric Stimulation; Guinea Pigs; Humans; In Vitro Techniques; Indoles; Male; Migraine Disorders; Models, Molecular; Oxazoles; Rabbits; Rats; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Regional Blood Flow; Serotonin Receptor Agonists; Serum Albumin, Bovine; Structure-Activity Relationship; Trigeminal Ganglion; Vasoconstrictor Agents

2001
The pre- and postjunctional activity of CP-122,288, a conformationally restricted analogue of sumatriptan.
    European journal of pharmacology, 1995, Apr-04, Volume: 276, Issue:3

    Topics: Animals; Basilar Artery; Blood Proteins; Capillary Permeability; Cell Line; Dogs; Dura Mater; Female; Haplorhini; Humans; In Vitro Techniques; Male; Molecular Conformation; Muscle Contraction; Muscle, Smooth, Vascular; Neuromuscular Junction; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Saphenous Vein; Sumatriptan

1995
Effect of a 5-HT1 receptor agonist, CP-122,288, on oedema formation induced by stimulation of the rat saphenous nerve.
    British journal of pharmacology, 1995, Volume: 115, Issue:1

    Topics: Analysis of Variance; Animals; Edema; Electric Stimulation; Male; Neuritis; Neurons, Afferent; Pyridines; Pyrroles; Pyrrolidines; Rats; Rats, Wistar; Serotonin Receptor Agonists; Sumatriptan

1995
Suppression by the sumatriptan analogue, CP-122,288 of c-fos immunoreactivity in trigeminal nucleus caudalis induced by intracisternal capsaicin.
    British journal of pharmacology, 1995, Volume: 114, Issue:5

    Topics: Animals; Aorta, Thoracic; Blood Pressure; Capsaicin; Cisterna Magna; Depression, Chemical; Guinea Pigs; Heart Rate; Immunohistochemistry; In Vitro Techniques; Injections; Male; Nociceptors; Proto-Oncogene Proteins c-fos; Pyrrolidines; Respiratory Mechanics; Sumatriptan; Trigeminal Ganglion

1995
Conformationally restricted sumatriptan analogues, CP-122,288 and CP-122,638 exhibit enhanced potency against neurogenic inflammation in dura mater.
    Brain research, 1993, Oct-29, Volume: 626, Issue:1-2

    Topics: Animals; Dura Mater; Electric Stimulation; Guinea Pigs; Male; Meningitis; Molecular Conformation; Pyrrolidines; Sumatriptan; Trigeminal Ganglion

1993
The in vivo pharmacological profile of a 5-HT1 receptor agonist, CP-122,288, a selective inhibitor of neurogenic inflammation.
    British journal of pharmacology, 1995, Volume: 116, Issue:5

    Topics: Anesthesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capillary Permeability; Dogs; Dose-Response Relationship, Drug; Dura Mater; Electric Stimulation; Hemodynamics; Inflammation; Male; Pyrrolidines; Rats; Rats, Sprague-Dawley; Serotonin Receptor Agonists; Species Specificity; Sumatriptan; Trigeminal Ganglion; Vasoconstriction

1995
[3H]sumatriptan labels both 5-HT1D and 5-HT1F receptor binding sites in the guinea pig brain: an autoradiographic study.
    Naunyn-Schmiedeberg's archives of pharmacology, 1995, Volume: 352, Issue:3

    Topics: Animals; Autoradiography; Binding, Competitive; Brain; Guinea Pigs; Iodine Radioisotopes; Isotope Labeling; Male; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin Receptor Agonists; Sumatriptan; Tissue Distribution

1995
5-Carboxamido-tryptamine, CP-122,288 and dihydroergotamine but not sumatriptan, CP-93,129, and serotonin-5-O-carboxymethyl-glycyl -tyrosinamide block dural plasma protein extravasation in knockout mice that lack 5-hydroxytryptamine1B receptors.
    Molecular pharmacology, 1996, Volume: 49, Issue:5

    Topics: Animals; Capillary Permeability; Dihydroergotamine; Dipeptides; Mice; Mice, Knockout; Pyridines; Pyrroles; Pyrrolidines; Receptors, Serotonin; Serotonin; Serotonin Receptor Agonists; Sumatriptan; Trigeminal Ganglion

1996
The 5-HT1D receptor antagonist GR-127,935 prevents inhibitory effects of sumatriptan but not CP-122,288 and 5-CT on neurogenic plasma extravasation within guinea pig dura mater.
    Neuropharmacology, 1997, Volume: 36, Issue:1

    Topics: Animals; Dose-Response Relationship, Drug; Dura Mater; Electric Stimulation; Female; Guinea Pigs; Male; Oxadiazoles; Pertussis Toxin; Piperazines; Prosencephalon; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Sumatriptan; Trigeminal Nerve; Virulence Factors, Bordetella

1997
A fluorescence-based method for assessing dural protein extravasation induced by trigeminal ganglion stimulation.
    Journal of neuroscience methods, 1998, Jun-01, Volume: 81, Issue:1-2

    Topics: Animals; Biological Transport; Dura Mater; Electric Stimulation; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; Fluorescence; Guinea Pigs; Inflammation; Injections, Intravenous; Male; Microscopy, Fluorescence; Microspectrophotometry; Migraine Disorders; Protein Binding; Proteins; Pyrrolidines; Sumatriptan; Trigeminal Ganglion

1998
Differential effects of low dose CP122,288 and eletriptan on fos expression due to stimulation of the superior sagittal sinus in cat.
    Pain, 1999, Volume: 82, Issue:1

    Topics: Animals; Cats; Cranial Sinuses; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Indoles; Neurons; Proto-Oncogene Proteins c-fos; Pyrrolidines; Serotonin Receptor Agonists; Stimulation, Chemical; Sumatriptan; Trigeminal Neuralgia; Tryptamines; Vasoconstrictor Agents

1999
Blockade of calcitonin gene-related peptide release after superior sagittal sinus stimulation in cat: a comparison of avitriptan and CP122,288.
    Neuropeptides, 1999, Volume: 33, Issue:1

    Topics: Animals; Calcitonin Gene-Related Peptide; Cats; Cerebral Arteries; Cerebrovascular Circulation; Cranial Sinuses; Electric Stimulation; Indoles; Jugular Veins; Migraine Disorders; Pyrrolidines; Serotonin Receptor Agonists; Sulfonamides; Sumatriptan; Trigeminal Nerve; Tryptamines

1999
pH-mediated field-amplified sample stacking of pharmaceutical cations in high-ionic strength samples.
    Electrophoresis, 2001, Volume: 22, Issue:1

    Topics: Cations; Doxazosin; Electrophoresis, Capillary; Hydrogen-Ion Concentration; Indoles; Isotonic Solutions; Osmolar Concentration; Phenethylamines; Piperazines; Purines; Pyrimidinones; Pyrrolidines; Ringer's Solution; Sildenafil Citrate; Sulfonamides; Sulfones; Sumatriptan; Tryptamines

2001