Page last updated: 2024-09-03

cp 115953 and novobiocin

cp 115953 has been researched along with novobiocin in 3 studies

Compound Research Comparison

Studies
(cp 115953)
Trials
(cp 115953)
Recent Studies (post-2010)
(cp 115953)
Studies
(novobiocin)
Trials
(novobiocin)
Recent Studies (post-2010) (novobiocin)
20002,27115290

Protein Interaction Comparison

ProteinTaxonomycp 115953 (IC50)novobiocin (IC50)
DNA gyrase subunit BMycolicibacterium smegmatis MC2 1550.046
DNA gyrase subunit BStaphylococcus aureus0.0474
DNA gyrase subunit BStreptococcus pneumoniae TIGR40.037
DNA gyrase subunit AEscherichia coli K-120.1441
DNA gyrase subunit BEscherichia coli K-120.1537
DNA topoisomerase 4 subunit BStaphylococcus aureus7.9
DNA gyrase subunit BMycolicibacterium smegmatis0.161
DNA gyrase subunit AStaphylococcus aureus0.0383
DNA gyrase subunit BMycobacterium tuberculosis H37Rv0.0446
DNA gyrase subunit AMycobacterium tuberculosis H37Rv0.1315
DNA topoisomerase Streptococcus pneumoniae2.03

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Forsgren, A; Riesbeck, K1
Corbett, AH; Osheroff, N; Robinson, MJ1
Corbett, AH; Hong, D; Osheroff, N1

Other Studies

3 other study(ies) available for cp 115953 and novobiocin

ArticleYear
CP-115,953 stimulates cytokine production by lymphocytes.
    Antimicrobial agents and chemotherapy, 1995, Volume: 39, Issue:2

    Topics: Anti-Infective Agents; Cells, Cultured; Cytokines; DNA Damage; Etoposide; Fluoroquinolones; Humans; Interferon-gamma; Interleukin-2; Lymphocyte Activation; Novobiocin; Quinolones; RNA, Messenger; T-Lymphocytes; Thymidine; Topoisomerase II Inhibitors

1995
Effects of topoisomerase II-targeted drugs on enzyme-mediated DNA cleavage and ATP hydrolysis: evidence for distinct drug interaction domains on topoisomerase II.
    Biochemistry, 1993, Apr-13, Volume: 32, Issue:14

    Topics: Adenosine Triphosphate; Amsacrine; Animals; Anti-Infective Agents; Antineoplastic Agents; Binding Sites; Cell Nucleus; DNA Topoisomerases, Type II; DNA, Bacterial; Drosophila melanogaster; Escherichia coli; Etoposide; Fluoroquinolones; Genistein; Hydrolysis; Isoflavones; Novobiocin; Plasmids; Quercetin; Quinolones; Topoisomerase II Inhibitors

1993
Exploiting mechanistic differences between drug classes to define functional drug interaction domains on topoisomerase II. Evidence that several diverse DNA cleavage-enhancing agents share a common site of action on the enzyme.
    The Journal of biological chemistry, 1993, Jul-05, Volume: 268, Issue:19

    Topics: Amsacrine; Animals; Anti-Infective Agents; Binding Sites; Cell Line; Cell Nucleus; DNA; DNA Topoisomerases, Type II; DNA, Superhelical; Drosophila melanogaster; Drug Interactions; Etoposide; Fluoroquinolones; Genistein; Growth Inhibitors; Isoflavones; Kinetics; Novobiocin; Protein Binding; Quinolones; Structure-Activity Relationship; Topoisomerase II Inhibitors

1993