Compounds > cp 115953
Page last updated: 2024-09-03

cp 115953 and genistein

cp 115953 has been researched along with genistein in 4 studies

Compound Research Comparison

Studies
(cp 115953)		Trials
(cp 115953)		Recent Studies (post-2010)
(cp 115953)		Studies
(genistein)		Trials
(genistein)		Recent Studies (post-2010) (genistein)
20007,4232042,311

Protein Interaction Comparison

ProteinTaxonomycp 115953 (IC50)genistein (IC50)
Chain A, Estrogen receptor 1 (alpha)Homo sapiens (human)0.009
Maltase-glucoamylase, intestinalHomo sapiens (human)2.61
Steroid hormone receptor ERR2Homo sapiens (human)0.395
Tyrosine-protein kinase ABL1Homo sapiens (human)5.5
Epidermal growth factor receptorHomo sapiens (human)1.2
TransthyretinHomo sapiens (human)7.8
Estrogen receptorHomo sapiens (human)1.3477
Steroid hormone receptor ERR1Homo sapiens (human)0.01
Polyunsaturated fatty acid lipoxygenase ALOX15Oryctolagus cuniculus (rabbit)9.033
17-beta-hydroxysteroid dehydrogenase type 1Homo sapiens (human)2.21
Protein kinase C alpha typeHomo sapiens (human)1
cAMP-dependent protein kinase catalytic subunit alphaHomo sapiens (human)1
Amine oxidase [flavin-containing] AHomo sapiens (human)4.184
Thromboxane-A synthase Homo sapiens (human)7.72
Amine oxidase [flavin-containing] BHomo sapiens (human)3.9333
Dipeptidyl peptidase 4Homo sapiens (human)0.48
Proteasome subunit beta type-5Homo sapiens (human)9.26
Sodium-dependent serotonin transporterRattus norvegicus (Norway rat)0.395
Tyrosine-protein kinase CSKHomo sapiens (human)1
Dual specificity mitogen-activated protein kinase kinase 4Homo sapiens (human)0.4
Xanthine dehydrogenase/oxidaseBos taurus (cattle)1.73
Aldehyde oxidaseHomo sapiens (human)0.34
Integrase Human immunodeficiency virus 11.1
Estrogen receptor betaHomo sapiens (human)0.3706
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)Plasmodium falciparum (malaria parasite P. falciparum)7
Solute carrier organic anion transporter family member 1B3Homo sapiens (human)3.8905
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)7.85
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)9.1201

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Corbett, AH; Elsea, SH; Osheroff, N; Westergaard, M1
Corbett, AH; Osheroff, N; Robinson, MJ1
Corbett, AH; Hong, D; Osheroff, N1
Burden, DA; Elsea, SH; Lomenick, JP; Osheroff, N; Westergaard, M1

Reviews

1 review(s) available for cp 115953 and genistein

ArticleYear
Defining functional drug-interaction domains on topoisomerase II by exploiting mechanistic differences between drug classes.
    Cancer chemotherapy and pharmacology, 1994, Volume: 34 Suppl

    Topics: Amsacrine; Animals; Anti-Infective Agents; Antineoplastic Agents; DNA; DNA Damage; DNA Topoisomerases, Type II; Etoposide; Fluoroquinolones; Genistein; Humans; Isoflavones; Models, Structural; Quinolones; Topoisomerase II Inhibitors

1994

Other Studies

3 other study(ies) available for cp 115953 and genistein

ArticleYear
Effects of topoisomerase II-targeted drugs on enzyme-mediated DNA cleavage and ATP hydrolysis: evidence for distinct drug interaction domains on topoisomerase II.
    Biochemistry, 1993, Apr-13, Volume: 32, Issue:14

    Topics: Adenosine Triphosphate; Amsacrine; Animals; Anti-Infective Agents; Antineoplastic Agents; Binding Sites; Cell Nucleus; DNA Topoisomerases, Type II; DNA, Bacterial; Drosophila melanogaster; Escherichia coli; Etoposide; Fluoroquinolones; Genistein; Hydrolysis; Isoflavones; Novobiocin; Plasmids; Quercetin; Quinolones; Topoisomerase II Inhibitors

1993
Exploiting mechanistic differences between drug classes to define functional drug interaction domains on topoisomerase II. Evidence that several diverse DNA cleavage-enhancing agents share a common site of action on the enzyme.
    The Journal of biological chemistry, 1993, Jul-05, Volume: 268, Issue:19

    Topics: Amsacrine; Animals; Anti-Infective Agents; Binding Sites; Cell Line; Cell Nucleus; DNA; DNA Topoisomerases, Type II; DNA, Superhelical; Drosophila melanogaster; Drug Interactions; Etoposide; Fluoroquinolones; Genistein; Growth Inhibitors; Isoflavones; Kinetics; Novobiocin; Protein Binding; Quinolones; Structure-Activity Relationship; Topoisomerase II Inhibitors

1993
Quinolones share a common interaction domain on topoisomerase II with other DNA cleavage-enhancing antineoplastic drugs.
    Biochemistry, 1997, Mar-11, Volume: 36, Issue:10

    Topics: Amsacrine; Animals; Anti-Infective Agents; Antineoplastic Agents; Binding Sites; CHO Cells; Ciprofloxacin; Cricetinae; DNA Topoisomerases, Type II; DNA, Superhelical; Drosophila melanogaster; Electrophoresis, Agar Gel; Enzyme Activation; Etoposide; Fluoroquinolones; Genistein; Isoflavones; Kinetics; Molecular Structure; Quinolones

1997