Page last updated: 2024-09-03

cp 115953 and carbostyril

cp 115953 has been researched along with carbostyril in 15 studies

Compound Research Comparison

Studies
(cp 115953)
Trials
(cp 115953)
Recent Studies (post-2010)
(cp 115953)
Studies
(carbostyril)
Trials
(carbostyril)
Recent Studies (post-2010) (carbostyril)
200012,8551,3235,611

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's15 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Elsea, SH; Nitiss, JL; Osheroff, N1
Gootz, TD; Martin, BA; McGuirk, PR; Osheroff, N; Robinson, MJ1
Gootz, TD; Martin, BA; McGuirk, PR; Moynihan, M; Osheroff, N; Robinson, MJ; Sutcliffe, JA1
Chung, IK; Gootz, TD; McGuirk, PR; Muller, MT; Spitzner, JR1
Elsea, SH; Hsiung, Y; Nitiss, JL; Osheroff, N2
Forsgren, A; Riesbeck, K1
Corbett, AH; Elsea, SH; Osheroff, N; Westergaard, M1
Elsea, SH; Gootz, TD; McGuirk, PR; Moynihan, M; Osheroff, N1
Corbett, AH; Osheroff, N; Robinson, MJ1
Corbett, AH; Hong, D; Osheroff, N1
Borde, V; Duguet, M2
Burden, DA; Elsea, SH; Lomenick, JP; Osheroff, N; Westergaard, M1
Anderson, VE; Gootz, TD; Kaczmarek, FS; Osheroff, N; Zaniewski, RP1

Reviews

1 review(s) available for cp 115953 and carbostyril

ArticleYear
Defining functional drug-interaction domains on topoisomerase II by exploiting mechanistic differences between drug classes.
    Cancer chemotherapy and pharmacology, 1994, Volume: 34 Suppl

    Topics: Amsacrine; Animals; Anti-Infective Agents; Antineoplastic Agents; DNA; DNA Damage; DNA Topoisomerases, Type II; Etoposide; Fluoroquinolones; Genistein; Humans; Isoflavones; Models, Structural; Quinolones; Topoisomerase II Inhibitors

1994

Other Studies

14 other study(ies) available for cp 115953 and carbostyril

ArticleYear
Cytotoxicity of quinolones toward eukaryotic cells. Identification of topoisomerase II as the primary cellular target for the quinolone CP-115,953 in yeast.
    The Journal of biological chemistry, 1992, Jul-05, Volume: 267, Issue:19

    Topics: Anti-Infective Agents; Cell Survival; DNA Damage; DNA Topoisomerases, Type II; Fluoroquinolones; Mutation; Quinolones; Saccharomyces cerevisiae; Topoisomerase II Inhibitors

1992
Effects of novel fluoroquinolones on the catalytic activities of eukaryotic topoisomerase II: Influence of the C-8 fluorine group.
    Antimicrobial agents and chemotherapy, 1992, Volume: 36, Issue:4

    Topics: Animals; Anti-Infective Agents; CHO Cells; Cricetinae; DNA; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Drosophila melanogaster; Electrophoresis, Agar Gel; Fluoroquinolones; In Vitro Techniques; Quinolones

1992
Effects of quinolone derivatives on eukaryotic topoisomerase II. A novel mechanism for enhancement of enzyme-mediated DNA cleavage.
    The Journal of biological chemistry, 1991, Aug-05, Volume: 266, Issue:22

    Topics: Animals; Anti-Infective Agents; Catalysis; Cell Line; Cell Survival; Cricetinae; Cricetulus; DNA; DNA Topoisomerases, Type II; Drosophila melanogaster; Electrophoresis, Agar Gel; Etoposide; Fluoroquinolones; Hydrolysis; Molecular Structure; Quinolones

1991
Analysis of eukaryotic topoisomerase II cleavage sites in the presence of the quinolone CP-115,953 reveals drug-dependent and -independent recognition elements.
    Molecular pharmacology, 1995, Volume: 48, Issue:2

    Topics: Amsacrine; Anti-Infective Agents; Base Sequence; DNA; DNA Topoisomerases, Type II; Etoposide; Fluoroquinolones; Humans; Hydrolysis; Molecular Sequence Data; Quinolones; Teniposide; Topoisomerase II Inhibitors

1995
A mutation in yeast TOP2 homologous to a quinolone-resistant mutation in bacteria. Mutation of the amino acid homologous to Ser83 of Escherichia coli gyrA alters sensitivity to eukaryotic topoisomerase inhibitors.
    The Journal of biological chemistry, 1995, Sep-01, Volume: 270, Issue:35

    Topics: Anti-Infective Agents; Base Sequence; DNA Topoisomerases, Type II; Drug Resistance, Microbial; Escherichia coli; Etoposide; Fluoroquinolones; Genes, Bacterial; Genes, Fungal; Kinetics; Macromolecular Substances; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Point Mutation; Quinolones; Recombinant Proteins; Saccharomyces cerevisiae; Serine; Species Specificity; Tryptophan

1995
CP-115,953 stimulates cytokine production by lymphocytes.
    Antimicrobial agents and chemotherapy, 1995, Volume: 39, Issue:2

    Topics: Anti-Infective Agents; Cells, Cultured; Cytokines; DNA Damage; Etoposide; Fluoroquinolones; Humans; Interferon-gamma; Interleukin-2; Lymphocyte Activation; Novobiocin; Quinolones; RNA, Messenger; T-Lymphocytes; Thymidine; Topoisomerase II Inhibitors

1995
A yeast type II topoisomerase selected for resistance to quinolones. Mutation of histidine 1012 to tyrosine confers resistance to nonintercalative drugs but hypersensitivity to ellipticine.
    The Journal of biological chemistry, 1995, Jan-27, Volume: 270, Issue:4

    Topics: Amino Acid Sequence; Animals; Anti-Infective Agents; DNA Topoisomerases, Type II; Drug Resistance; Ellipticines; Fluoroquinolones; Histidine; Humans; Kinetics; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Point Mutation; Quinolones; Recombinant Proteins; Saccharomyces cerevisiae; Sequence Homology, Amino Acid; Topoisomerase II Inhibitors; Tyrosine

1995
Drug features that contribute to the activity of quinolones against mammalian topoisomerase II and cultured cells: correlation between enhancement of enzyme-mediated DNA cleavage in vitro and cytotoxic potential.
    Antimicrobial agents and chemotherapy, 1993, Volume: 37, Issue:10

    Topics: Animals; Anti-Infective Agents; Cattle; Cell Death; Cells, Cultured; CHO Cells; Cricetinae; DNA; Fluoroquinolones; Humans; Nucleic Acid Conformation; Quinolones; Structure-Activity Relationship; Topoisomerase II Inhibitors

1993
Effects of topoisomerase II-targeted drugs on enzyme-mediated DNA cleavage and ATP hydrolysis: evidence for distinct drug interaction domains on topoisomerase II.
    Biochemistry, 1993, Apr-13, Volume: 32, Issue:14

    Topics: Adenosine Triphosphate; Amsacrine; Animals; Anti-Infective Agents; Antineoplastic Agents; Binding Sites; Cell Nucleus; DNA Topoisomerases, Type II; DNA, Bacterial; Drosophila melanogaster; Escherichia coli; Etoposide; Fluoroquinolones; Genistein; Hydrolysis; Isoflavones; Novobiocin; Plasmids; Quercetin; Quinolones; Topoisomerase II Inhibitors

1993
Exploiting mechanistic differences between drug classes to define functional drug interaction domains on topoisomerase II. Evidence that several diverse DNA cleavage-enhancing agents share a common site of action on the enzyme.
    The Journal of biological chemistry, 1993, Jul-05, Volume: 268, Issue:19

    Topics: Amsacrine; Animals; Anti-Infective Agents; Binding Sites; Cell Line; Cell Nucleus; DNA; DNA Topoisomerases, Type II; DNA, Superhelical; Drosophila melanogaster; Drug Interactions; Etoposide; Fluoroquinolones; Genistein; Growth Inhibitors; Isoflavones; Kinetics; Novobiocin; Protein Binding; Quinolones; Structure-Activity Relationship; Topoisomerase II Inhibitors

1993
In vivo topoisomerase II cleavage sites in the ribosomal DNA of Physarum polycephalum.
    Biochemistry, 1996, May-07, Volume: 35, Issue:18

    Topics: Animals; Anti-Infective Agents; Antineoplastic Agents; Binding Sites; Cell Nucleus; Chromatin; DNA Topoisomerases, Type II; DNA, Fungal; DNA, Protozoan; DNA, Ribosomal; Enzyme Inhibitors; Fluoroquinolones; Physarum polycephalum; Quinolones; Topoisomerase II Inhibitors

1996
Quinolones share a common interaction domain on topoisomerase II with other DNA cleavage-enhancing antineoplastic drugs.
    Biochemistry, 1997, Mar-11, Volume: 36, Issue:10

    Topics: Amsacrine; Animals; Anti-Infective Agents; Antineoplastic Agents; Binding Sites; CHO Cells; Ciprofloxacin; Cricetinae; DNA Topoisomerases, Type II; DNA, Superhelical; Drosophila melanogaster; Electrophoresis, Agar Gel; Enzyme Activation; Etoposide; Fluoroquinolones; Genistein; Isoflavones; Kinetics; Molecular Structure; Quinolones

1997
DNA topoisomerase II sites in the histone H4 gene during the highly synchronous cell cycle of Physarum polycephalum.
    Nucleic acids research, 1998, May-01, Volume: 26, Issue:9

    Topics: Animals; Anti-Infective Agents; Cell Cycle; Cell Nucleus; Deoxyribonuclease I; DNA Topoisomerases, Type II; DNA, Protozoan; Electrophoresis, Gel, Pulsed-Field; Fluoroquinolones; Genes, Protozoan; Histones; Periodicity; Physarum polycephalum; Quinolones; Subcellular Fractions

1998
Quinolones inhibit DNA religation mediated by Staphylococcus aureus topoisomerase IV. Changes in drug mechanism across evolutionary boundaries.
    The Journal of biological chemistry, 1999, Dec-10, Volume: 274, Issue:50

    Topics: Anti-Infective Agents; Biological Evolution; Ciprofloxacin; DNA Damage; DNA Repair; DNA Topoisomerase IV; DNA Topoisomerases, Type II; Escherichia coli; Etoposide; Fluoroquinolones; Gram-Positive Bacteria; Kinetics; Quinolones; Staphylococcus aureus

1999