Page last updated: 2024-09-03

cp 115953 and amsacrine

cp 115953 has been researched along with amsacrine in 7 studies

*Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent. [MeSH]

*Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent. [MeSH]

Compound Research Comparison

Studies
(cp 115953)
Trials
(cp 115953)
Recent Studies (post-2010)
(cp 115953)
Studies
(amsacrine)
Trials
(amsacrine)
Recent Studies (post-2010) (amsacrine)
20001,293127120

Protein Interaction Comparison

ProteinTaxonomycp 115953 (IC50)amsacrine (IC50)
Solute carrier family 22 member 1 Homo sapiens (human)5
Multidrug resistance-associated protein 4Homo sapiens (human)7.43
DNA topoisomerase 2-alphaHomo sapiens (human)5.47
5-hydroxytryptamine receptor 7Cavia porcellus (domestic guinea pig)5
DNA topoisomerase 2-betaHomo sapiens (human)1.88
Aldehyde oxidaseHomo sapiens (human)3.2
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)0.2095
Aldehyde oxidase 1 Rattus norvegicus (Norway rat)6.4

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (85.71)18.2507
2000's1 (14.29)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Aldous, SC; Coughlin, SA; Dorff, PH; Gruett, MD; Lesher, GY; Rake, JB; Reuman, M; Singh, B; Wentland, MP1
Chung, IK; Gootz, TD; McGuirk, PR; Muller, MT; Spitzner, JR1
Corbett, AH; Elsea, SH; Osheroff, N; Westergaard, M1
Corbett, AH; Osheroff, N; Robinson, MJ1
Corbett, AH; Hong, D; Osheroff, N1
Burden, DA; Elsea, SH; Lomenick, JP; Osheroff, N; Westergaard, M1
Dong, J; Nitiss, JL; Walker, J1

Reviews

1 review(s) available for cp 115953 and amsacrine

ArticleYear
Defining functional drug-interaction domains on topoisomerase II by exploiting mechanistic differences between drug classes.
    Cancer chemotherapy and pharmacology, 1994, Volume: 34 Suppl

    Topics: Amsacrine; Animals; Anti-Infective Agents; Antineoplastic Agents; DNA; DNA Damage; DNA Topoisomerases, Type II; Etoposide; Fluoroquinolones; Genistein; Humans; Isoflavones; Models, Structural; Quinolones; Topoisomerase II Inhibitors

1994

Other Studies

6 other study(ies) available for cp 115953 and amsacrine

ArticleYear
Mammalian topoisomerase II inhibitory activity of 1-cyclopropyl-6,8- difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarb oxylic acid and related derivatives.
    Journal of medicinal chemistry, 1993, Sep-17, Volume: 36, Issue:19

    Topics: Animals; Anti-Infective Agents; Fluoroquinolones; HeLa Cells; Humans; Leukemia P388; Mice; Quinolones; Structure-Activity Relationship; Topoisomerase II Inhibitors

1993
Analysis of eukaryotic topoisomerase II cleavage sites in the presence of the quinolone CP-115,953 reveals drug-dependent and -independent recognition elements.
    Molecular pharmacology, 1995, Volume: 48, Issue:2

    Topics: Amsacrine; Anti-Infective Agents; Base Sequence; DNA; DNA Topoisomerases, Type II; Etoposide; Fluoroquinolones; Humans; Hydrolysis; Molecular Sequence Data; Quinolones; Teniposide; Topoisomerase II Inhibitors

1995
Effects of topoisomerase II-targeted drugs on enzyme-mediated DNA cleavage and ATP hydrolysis: evidence for distinct drug interaction domains on topoisomerase II.
    Biochemistry, 1993, Apr-13, Volume: 32, Issue:14

    Topics: Adenosine Triphosphate; Amsacrine; Animals; Anti-Infective Agents; Antineoplastic Agents; Binding Sites; Cell Nucleus; DNA Topoisomerases, Type II; DNA, Bacterial; Drosophila melanogaster; Escherichia coli; Etoposide; Fluoroquinolones; Genistein; Hydrolysis; Isoflavones; Novobiocin; Plasmids; Quercetin; Quinolones; Topoisomerase II Inhibitors

1993
Exploiting mechanistic differences between drug classes to define functional drug interaction domains on topoisomerase II. Evidence that several diverse DNA cleavage-enhancing agents share a common site of action on the enzyme.
    The Journal of biological chemistry, 1993, Jul-05, Volume: 268, Issue:19

    Topics: Amsacrine; Animals; Anti-Infective Agents; Binding Sites; Cell Line; Cell Nucleus; DNA; DNA Topoisomerases, Type II; DNA, Superhelical; Drosophila melanogaster; Drug Interactions; Etoposide; Fluoroquinolones; Genistein; Growth Inhibitors; Isoflavones; Kinetics; Novobiocin; Protein Binding; Quinolones; Structure-Activity Relationship; Topoisomerase II Inhibitors

1993
Quinolones share a common interaction domain on topoisomerase II with other DNA cleavage-enhancing antineoplastic drugs.
    Biochemistry, 1997, Mar-11, Volume: 36, Issue:10

    Topics: Amsacrine; Animals; Anti-Infective Agents; Antineoplastic Agents; Binding Sites; CHO Cells; Ciprofloxacin; Cricetinae; DNA Topoisomerases, Type II; DNA, Superhelical; Drosophila melanogaster; Electrophoresis, Agar Gel; Enzyme Activation; Etoposide; Fluoroquinolones; Genistein; Isoflavones; Kinetics; Molecular Structure; Quinolones

1997
A mutation in yeast topoisomerase II that confers hypersensitivity to multiple classes of topoisomerase II poisons.
    The Journal of biological chemistry, 2000, Mar-17, Volume: 275, Issue:11

    Topics: Amsacrine; Anti-Infective Agents; Binding Sites; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Enzyme Inhibitors; Eukaryotic Cells; Fluoroquinolones; Intercalating Agents; Models, Molecular; Mutation; Protein Structure, Tertiary; Saccharomyces cerevisiae; Topoisomerase II Inhibitors

2000