Page last updated: 2024-09-04

cox 189 and roflumilast

cox 189 has been researched along with roflumilast in 1 studies

Compound Research Comparison

Studies (cox 189)	Trials (cox 189)	Recent Studies (post-2010) (cox 189)	Studies (roflumilast)	Trials (roflumilast)	Recent Studies (post-2010) (roflumilast)
163	49	47	566	90	425

Protein Interaction Comparison

Protein	Taxonomy	roflumilast (IC50)
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Homo sapiens (human)	0.0008
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Homo sapiens (human)	0.0008
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Homo sapiens (human)	0.0008
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Homo sapiens (human)	0.0008
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Homo sapiens (human)	0.0008
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Homo sapiens (human)	0.0008
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Homo sapiens (human)	0.0008
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Homo sapiens (human)	0.0008
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Homo sapiens (human)	0.0008
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Homo sapiens (human)	0.0008
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Homo sapiens (human)	0.0008
Chain B, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Homo sapiens (human)	0.0008
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase	Homo sapiens (human)	0.0008
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase	Homo sapiens (human)	0.0008
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Homo sapiens (human)	0.0058
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Homo sapiens (human)	0.0058
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Homo sapiens (human)	0.0058
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Homo sapiens (human)	0.0058
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Homo sapiens (human)	0.0058
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Homo sapiens (human)	0.0058
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Homo sapiens (human)	0.0058
cGMP-dependent 3',5'-cyclic phosphodiesterase	Homo sapiens (human)	0.0008
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	Homo sapiens (human)	0.0008
cGMP-specific 3',5'-cyclic phosphodiesterase	Homo sapiens (human)	0.0008
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	Homo sapiens (human)	0.0005
Sodium-dependent serotonin transporter	Rattus norvegicus (Norway rat)	0.0003
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	Homo sapiens (human)	0.0008
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Homo sapiens (human)	0.025
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	Homo sapiens (human)	0.0008
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Homo sapiens (human)	0.0475
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Homo sapiens (human)	0.0008
Beta-2 adrenergic receptor	Cavia porcellus (domestic guinea pig)	0.001
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	Homo sapiens (human)	0.0008
cAMP-specific 3',5'-cyclic phosphodiesterase 7B	Homo sapiens (human)	0.0008
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Homo sapiens (human)	0.0008

Research

Studies (1)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (100.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Colbatzky, F; Göggel, R; Nickolaus, P; Peter, D	1

Other Studies

1 other study(ies) available for cox 189 and roflumilast

Article	Year
Inhibition of cyclooxygenase-2 prevents adverse effects induced by phosphodiesterase type 4 inhibitors in rats. British journal of pharmacology, 2011, Volume: 162, Issue:2 Topics: Acute Lung Injury; Aminopyridines; Animals; Benzamides; Bronchoalveolar Lavage Fluid; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cyclopropanes; Diclofenac; Disease Models, Animal; Humans; Inflammation; Lipopolysaccharides; Male; Neutrophil Infiltration; Phosphodiesterase 4 Inhibitors; Pyrazoles; Rats; Rats, Wistar	2011

Article

Year

Inhibition of cyclooxygenase-2 prevents adverse effects induced by phosphodiesterase type 4 inhibitors in rats.

British journal of pharmacology, 2011, Volume: 162, Issue:2

Topics: Acute Lung Injury; Aminopyridines; Animals; Benzamides; Bronchoalveolar Lavage Fluid; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cyclopropanes; Diclofenac; Disease Models, Animal; Humans; Inflammation; Lipopolysaccharides; Male; Neutrophil Infiltration; Phosphodiesterase 4 Inhibitors; Pyrazoles; Rats; Rats, Wistar

2011