Page last updated: 2024-09-04

cox 189 and lapatinib

cox 189 has been researched along with lapatinib in 5 studies

Compound Research Comparison

Studies
(cox 189)
Trials
(cox 189)
Recent Studies (post-2010)
(cox 189)
Studies
(lapatinib)
Trials
(lapatinib)
Recent Studies (post-2010) (lapatinib)
16349471,9193051,442

Protein Interaction Comparison

ProteinTaxonomycox 189 (IC50)lapatinib (IC50)
Bile salt export pumpHomo sapiens (human)7.375
Epidermal growth factor receptorHomo sapiens (human)0.0827
Receptor tyrosine-protein kinase erbB-2Homo sapiens (human)0.0537
Platelet-derived growth factor receptor betaHomo sapiens (human)8.5
D(1A) dopamine receptorSus scrofa (pig)0.06
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)1
Receptor tyrosine-protein kinase erbB-4Homo sapiens (human)0.1659
Alpha-1A adrenergic receptor Sus scrofa (pig)0.06
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)3.2

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ekins, S; Williams, AJ; Xu, JJ1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Kaniwa, N; Saito, Y1
Aklillu, E; Makonnen, E; Petros, Z1

Reviews

2 review(s) available for cox 189 and lapatinib

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Pharmacogenomics of severe cutaneous adverse reactions and drug-induced liver injury.
    Journal of human genetics, 2013, Volume: 58, Issue:6

    Topics: Alleles; Allopurinol; Amoxicillin-Potassium Clavulanate Combination; Azetidines; Benzylamines; Carbamazepine; Chemical and Drug Induced Liver Injury; Diclofenac; Dideoxynucleosides; Drug Hypersensitivity; Floxacillin; Genetic Markers; HLA Antigens; HLA-A Antigens; HLA-B Antigens; HLA-DQ alpha-Chains; Humans; Lapatinib; Pharmacogenetics; Quinazolines; Skin; Stevens-Johnson Syndrome; Ticlopidine

2013

Other Studies

3 other study(ies) available for cox 189 and lapatinib

ArticleYear
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
Genome-Wide Association Studies for Idiosyncratic Drug-Induced Hepatotoxicity: Looking Back-Looking Forward to Next-Generation Innovation.
    Omics : a journal of integrative biology, 2017, Volume: 21, Issue:3

    Topics: Amoxicillin-Potassium Clavulanate Combination; Cell Adhesion Molecules; Chemical and Drug Induced Liver Injury; Diclofenac; Floxacillin; Genome-Wide Association Study; Genotype; HLA-B Antigens; HLA-DQ beta-Chains; HLA-DRB1 Chains; Humans; Lapatinib; Liver; Proteins; Quinazolines

2017