Compounds > cox 189
Page last updated: 2024-09-04

cox 189 and benzbromarone

cox 189 has been researched along with benzbromarone in 4 studies

Compound Research Comparison

Studies
(cox 189)		Trials
(cox 189)		Recent Studies (post-2010)
(cox 189)		Studies
(benzbromarone)		Trials
(benzbromarone)		Recent Studies (post-2010) (benzbromarone)
163494748259208

Protein Interaction Comparison

ProteinTaxonomycox 189 (IC50)benzbromarone (IC50)
envelope glycoproteinHuman immunodeficiency virus 112.8
nuclear receptor corepressor 2 isoform 2Homo sapiens (human)4.811
peroxisome proliferator-activated receptor gamma isoform 2Homo sapiens (human)4.811
Adenosine receptor A3Homo sapiens (human)5.222
60 kDa heat shock protein, mitochondrialHomo sapiens (human)9.1
Cytochrome P450 2C9 Homo sapiens (human)1.0895
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)5.222
Mitogen-activated protein kinase 1Homo sapiens (human)1.946
Multidrug resistance-associated protein 1 Homo sapiens (human)4
5-hydroxytryptamine receptor 2BHomo sapiens (human)1.804
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)5.222
Cytochrome P450 2J2Homo sapiens (human)4.26
10 kDa heat shock protein, mitochondrialHomo sapiens (human)9.1
Aldo-keto reductase family 1 member C1Homo sapiens (human)0.048
Mitogen-activated protein kinase 14Homo sapiens (human)1.235
Solute carrier family 22 member 6Homo sapiens (human)4.6
Monocarboxylate transporter 2Rattus norvegicus (Norway rat)9
Solute carrier family 22 member 12Homo sapiens (human)0.8695
Eyes absent homolog 3Homo sapiens (human)8.3
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)0.2
M17 leucyl aminopeptidasePlasmodium falciparum 3D781.89
M1-family alanyl aminopeptidasePlasmodium falciparum 3D762.78

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ekins, S; Williams, AJ; Xu, JJ1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1

Reviews

1 review(s) available for cox 189 and benzbromarone

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Other Studies

3 other study(ies) available for cox 189 and benzbromarone

ArticleYear
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013