Compounds > cox 189
Page last updated: 2024-09-04

cox 189 and astemizole

cox 189 has been researched along with astemizole in 2 studies

Compound Research Comparison

Studies
(cox 189)		Trials
(cox 189)		Recent Studies (post-2010)
(cox 189)		Studies
(astemizole)		Trials
(astemizole)		Recent Studies (post-2010) (astemizole)
16349471,130117578

Protein Interaction Comparison

ProteinTaxonomycox 189 (IC50)astemizole (IC50)
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)1.1
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.179
Bile salt export pumpHomo sapiens (human)10
Epidermal growth factor receptorHomo sapiens (human)6.057
Tyrosine-protein kinase FynHomo sapiens (human)2.847
ATP-dependent translocase ABCB1Mus musculus (house mouse)1.7
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)1.375
Muscarinic acetylcholine receptor M2Homo sapiens (human)1.409
Muscarinic acetylcholine receptor M4Homo sapiens (human)1.861
ATP-dependent translocase ABCB1Homo sapiens (human)0.9667
Cytochrome P450 3A4Homo sapiens (human)3.3
Muscarinic acetylcholine receptor M5Homo sapiens (human)0.703
Alpha-2A adrenergic receptorHomo sapiens (human)4.846
Muscarinic acetylcholine receptor M1Homo sapiens (human)1.066
Beta-3 adrenergic receptorHomo sapiens (human)8.06
D(2) dopamine receptorHomo sapiens (human)4.521
Alpha-2B adrenergic receptorHomo sapiens (human)3.839
Alpha-2C adrenergic receptorHomo sapiens (human)1.959
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)0.767
Muscarinic acetylcholine receptor M3Homo sapiens (human)0.84
ATP-dependent translocase ABCB1Mus musculus (house mouse)1.3
Substance-K receptorHomo sapiens (human)2.986
D(1A) dopamine receptorHomo sapiens (human)4.01
D(4) dopamine receptorHomo sapiens (human)6.087
Sodium-dependent noradrenaline transporter Homo sapiens (human)1.375
Histamine H2 receptorHomo sapiens (human)1.682
Alpha-1D adrenergic receptorHomo sapiens (human)0.769
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.02
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.179
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)0.767
Sodium-dependent serotonin transporterHomo sapiens (human)1.318
Melanocortin receptor 5Homo sapiens (human)2.263
Histamine H1 receptorHomo sapiens (human)0.014
Mu-type opioid receptorHomo sapiens (human)1.492
D(3) dopamine receptorHomo sapiens (human)0.436
Kappa-type opioid receptorHomo sapiens (human)6.616
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.012
5-hydroxytryptamine receptor 6Homo sapiens (human)3.266
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)1.1
Sodium-dependent dopamine transporter Homo sapiens (human)0.998
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)0.2857
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)1.1
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)1.1
Sigma non-opioid intracellular receptor 1Homo sapiens (human)2.246

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ekins, S; Williams, AJ; Xu, JJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1

Other Studies

2 other study(ies) available for cox 189 and astemizole

ArticleYear
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013