coumestrol has been researched along with hydroxyethylcellulose* in 1 studies
1 other study(ies) available for coumestrol and hydroxyethylcellulose
| Article | Year |
|---|---|
Topical Delivery of Coumestrol from Lipid Nanoemulsions Thickened with Hydroxyethylcellulose for Antiherpes Treatment.
We have recently shown that coumestrol, an isoflavonoid-like compound naturally occurring in soybeans, alfafa, and red clover, inhibited Herpes Simplex Virus types 1 (HSV-1) and 2 (HSV-2) replication. In this study, we designed coumestrol formulations in an attempt to enable its topical delivery to mucosa tissues. Physicochemical and microscopic examinations suggested that coumestrol was efficiently incorporated in positively-charged nanoemulsions dispersed in a hydroxyethylcellulose gel. The higher coumestrol flux through excised porcine esophageal mucosa was detected from nanoemulsions composed by a fluid phospholipid (dioleylphosphocholine, DOPC) in comparison with that of a rigid one (distearoylphosphocholine, DSPC) in two mucosa conditions (intact and injured). Such results were supported by confocal fluorescence images. Furthermore, the low IC Topics: Administration, Topical; Animals; Antiviral Agents; Cellulose; Coumestrol; Emulsions; Herpesvirus 1, Human; Herpesvirus 2, Human; Mucous Membrane; Phosphorylcholine; Swine | 2018 |