coumarin and tacrine

coumarin has been researched along with tacrine in 12 studies

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (8.33)29.6817
2010's11 (91.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Al-Rashid, ZF; Beri, V; Cheung, J; Rosenberry, TL; Shiomi, K; Wildman, SA1
Barbosa, G; Ceschi, MA; Dantas, RF; Dardenne, LE; de Salles, CMC; Guedes, IA; Lima, LM; Lopes, JPB; Lüdtke, DS; Ruaro, TC; Senger, MR; Silva, L; Silva-Jr, FP; Zimmer, AR1
Kong, LY; Li, JY; Wang, XB; Xie, SS; Yang, L1
Alipour, M; Foroumadi, A; Ghandi, M; Khoobi, M; Moradi, A; Nadri, H; Razavi, SF; Sakhteman, A; Shafiee, A1
Peng, DY; Sun, Q; Yang, GF; Yang, SG; Yang, WC; Zhu, XL1
Hamulakova, S; Hrabinova, M; Imrich, J; Janovec, L; Korabecny, J; Kristian, P; Kuca, K; Spilovska, K1
Jiang, N; Kong, LY; Lan, JS; Li, ZR; Wang, KD; Wang, X; Xie, SS; Yu, W1
Bednarikova, Z; Gazova, Z; Hamulakova, S; Holztragerova, M; Hsu, WT; Ulicna, K; Wang, SS; Wu, JW1
Hamulakova, S; Hrabinova, M; Janockova, J; Janovec, L; Jun, D; Kuca, K; Sepsova, V; Soukup, O1

Other Studies

12 other study(ies) available for coumarin and tacrine

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
The natural product dihydrotanshinone I provides a prototype for uncharged inhibitors that bind specifically to the acetylcholinesterase peripheral site with nanomolar affinity.
    Biochemistry, 2013, Oct-22, Volume: 52, Issue:42

    Topics: Acetylcholine; Acetylcholinesterase; Aflatoxin B1; Binding Sites; Binding, Competitive; Catalysis; Catalytic Domain; Cholinesterase Inhibitors; Crystallography, X-Ray; Furans; Humans; Hydrolysis; Kinetics; Models, Chemical; Phenanthrenes; Pyrans; Quinones; Recombinant Proteins; Structure-Activity Relationship; Substrate Specificity

2013
Synthesis of new lophine-carbohydrate hybrids as cholinesterase inhibitors: cytotoxicity evaluation and molecular modeling.
    MedChemComm, 2019, Dec-01, Volume: 10, Issue:12

    Topics:

2019
Design, synthesis and evaluation of novel tacrine-coumarin hybrids as multifunctional cholinesterase inhibitors against Alzheimer's disease.
    European journal of medicinal chemistry, 2013, Volume: 64

    Topics: Alzheimer Disease; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Cholinesterases; Coumarins; Dose-Response Relationship, Drug; Drug Design; Electrophorus; Models, Molecular; Molecular Structure; Structure-Activity Relationship; Tacrine

2013
Design, synthesis, docking study and biological evaluation of some novel tetrahydrochromeno [3',4':5,6]pyrano[2,3-b]quinolin-6(7H)-one derivatives against acetyl- and butyrylcholinesterase.
    European journal of medicinal chemistry, 2013, Volume: 68

    Topics: Acetylcholinesterase; Benzopyrans; Binding Sites; Butyrylcholinesterase; Cholinesterase Inhibitors; Coumarins; Drug Design; Enzyme Activation; Inhibitory Concentration 50; Models, Molecular; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship; Tacrine

2013
Syntheses of coumarin-tacrine hybrids as dual-site acetylcholinesterase inhibitors and their activity against butylcholinesterase, Aβ aggregation, and β-secretase.
    Bioorganic & medicinal chemistry, 2014, Sep-01, Volume: 22, Issue:17

    Topics: Acetylcholinesterase; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Cholinesterase Inhibitors; Cholinesterases; Coumarins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Molecular Structure; Structure-Activity Relationship; Tacrine

2014
Synthesis and biological evaluation of novel tacrine derivatives and tacrine-coumarin hybrids as cholinesterase inhibitors.
    Journal of medicinal chemistry, 2014, Aug-28, Volume: 57, Issue:16

    Topics: Acetylcholinesterase; Butyrylcholinesterase; Chemistry Techniques, Synthetic; Cholinesterase Inhibitors; Coumarins; Drug Evaluation, Preclinical; Humans; Inhibitory Concentration 50; Molecular Docking Simulation; Structure-Activity Relationship; Tacrine

2014
Multi-target tacrine-coumarin hybrids: cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease.
    European journal of medicinal chemistry, 2015, May-05, Volume: 95

    Topics: Acetylcholinesterase; Alzheimer Disease; Benzopyrans; Blood-Brain Barrier; Brain; Cell Survival; Cells, Cultured; Cholinesterase Inhibitors; Coumarins; Drug Design; Erythrocytes; Humans; Kinetics; Models, Molecular; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroblastoma; Piperazines; Tacrine

2015
Lysozyme amyloid fibrillization in presence of tacrine/acridone-coumarin heterodimers.
    Colloids and surfaces. B, Biointerfaces, 2018, Jun-01, Volume: 166

    Topics: Amyloid; Coumarins; Humans; Microscopy, Atomic Force; Muramidase; Tacrine

2018
Tacrine-coumarin and Tacrine-7-chloroquinoline Hybrids with Thiourea Linkers: Cholinesterase Inhibition Properties, Kinetic Study, Molecular Docking and Permeability Assay for Blood-brain Barrier.
    Current Alzheimer research, 2018, Volume: 15, Issue:12

    Topics: Animals; Blood-Brain Barrier; Cholinesterase Inhibitors; Coumarins; Humans; Kinetics; Models, Molecular; Molecular Docking Simulation; Permeability; Structure-Activity Relationship; Tacrine; Thiourea

2018