coumarin and quinidine

coumarin has been researched along with quinidine in 14 studies

Research

Studies (14)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (7.14)	18.7374
1990's	1 (7.14)	18.2507
2000's	8 (57.14)	29.6817
2010's	3 (21.43)	24.3611
2020's	1 (7.14)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Jolivette, LJ; Ward, KW	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Dai, R; Liu, Y; She, M; Wu, Z	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M	1
Jones, BC; Smith, DA; Tyman, CA	1
Cai, H; Guengerich, FP; Hanna, IH; Nakamura, K; Nishimura, Y; Williams, KM	1
Beckurts, KT; Brachtendorf, L; Fuhr, U; Hölscher, AH; Jetter, A	1
PREZIOSI, P	1
Fouda, HG; Khojasteh-Bakht, SC; Prakash, C; Rossulek, MI	1
Gottesdiener, KM; Kari, PP; Marbury, T; Miller, JL; Mistry, GC; Rodrigues, AD; Simpson, RC; Wagner, JA; Winchell, GA	1
Fuhr, U; Kober, S; Mutschler, E; Spahn-Langguth, H; Zaigler, M	1

Trials

1 trial(s) available for coumarin and quinidine

Article	Year
The effect of ketoconazole on the pharmacokinetics of a selective alpha 1A-adrenoceptor antagonist. Journal of clinical pharmacology, 2005, Volume: 45, Issue:6 Topics: Administration, Oral; Adrenergic alpha-1 Receptor Antagonists; Adult; Area Under Curve; Carbon Radioisotopes; Coumarins; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Fomepizole; Half-Life; Humans; Ketoconazole; Male; Microsomes, Liver; Pyrazoles; Pyrimidinones; Quinidine; Receptors, Adrenergic, alpha-1; Sulfaphenazole; Theophylline	2005

Article

Year

The effect of ketoconazole on the pharmacokinetics of a selective alpha 1A-adrenoceptor antagonist.

Journal of clinical pharmacology, 2005, Volume: 45, Issue:6

Topics: Administration, Oral; Adrenergic alpha-1 Receptor Antagonists; Adult; Area Under Curve; Carbon Radioisotopes; Coumarins; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Fomepizole; Half-Life; Humans; Ketoconazole; Male; Microsomes, Liver; Pyrazoles; Pyrimidinones; Quinidine; Receptors, Adrenergic, alpha-1; Sulfaphenazole; Theophylline

2005

Other Studies

13 other study(ies) available for coumarin and quinidine

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. Journal of pharmaceutical sciences, 2005, Volume: 94, Issue:7 Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution	2005
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
The inhibition study of human UDP-glucuronosyltransferases with cytochrome P450 selective substrates and inhibitors. Journal of enzyme inhibition and medicinal chemistry, 2011, Volume: 26, Issue:3 Topics: Cytochrome P-450 Enzyme Inhibitors; Enzyme Activation; Enzyme Inhibitors; Glucuronosyltransferase; Humans; Molecular Structure; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship; Substrate Specificity	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology. Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3 Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries	2023
Identification of the cytochrome P450 isoforms involved in the O-demethylation of 4-nitroanisole in human liver microsomes. Xenobiotica; the fate of foreign compounds in biological systems, 1997, Volume: 27, Issue:10 Topics: Adult; Aged; Anisoles; Anti-Infective Agents; Anticoagulants; Antifungal Agents; Antimalarials; Binding, Competitive; Coumarins; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Female; Humans; Isoenzymes; Ketoconazole; Kinetics; Male; Methylation; Microsomes, Liver; Middle Aged; Quinidine; Substrate Specificity; Sulfaphenazole; Theophylline	1997
Coumarin substrates for cytochrome P450 2D6 fluorescence assays. Analytical biochemistry, 2001, May-15, Volume: 292, Issue:2 Topics: Amino Acid Sequence; Catalysis; Coumarins; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Enzyme Inhibitors; Fluorescent Dyes; Humans; Kinetics; Microsomes, Liver; Molecular Sequence Data; Quinidine; Recombinant Proteins; Substrate Specificity	2001
Cytochrome P450 enzymes contributing to demethylation of maprotiline in man. Pharmacology & toxicology, 2002, Volume: 90, Issue:3 Topics: Cells, Cultured; Chlorzoxazone; Coumarins; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzymes; Humans; Ketoconazole; Kinetics; Maprotiline; Mephenytoin; Microsomes, Liver; Models, Biological; Quinidine; Sulfaphenazole; Theophylline	2002
[Therapy of myocardial infarct]. La Riforma medica, 1953, Feb-21, Volume: 67, Issue:8 Topics: Adenosine Triphosphate; Ascorbic Acid; Bile Acids and Salts; Coumarins; Diet; Folic Acid; Heparin; Humans; Hypnotics and Sedatives; Khellin; Magnesium Sulfate; Myocardial Infarction; Purines; Quinidine; Salts; Sympathomimetics; Vitamin B Complex; Vitamin E; Vitamins	1953
Identification of the human cytochrome P450s responsible for the in vitro metabolism of a leukotriene B4 receptor antagonist, CP-195,543. Xenobiotica; the fate of foreign compounds in biological systems, 2003, Volume: 33, Issue:12 Topics: Adolescent; Adult; Aged; Chromans; Coumarins; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Female; Humans; Ketoconazole; Kinetics; Male; Mephenytoin; Microsomes, Liver; Middle Aged; NADP; Oxidation-Reduction; Quinidine; Receptors, Leukotriene B4; Recombinant Proteins; Sulfaphenazole; Theophylline	2003
Rate-limiting biotransformation of triamterene is mediated by CYP1A2. International journal of clinical pharmacology and therapeutics, 2005, Volume: 43, Issue:7 Topics: Caffeine; Chromatography, High Pressure Liquid; Coumarins; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythromycin; Humans; Hydroxylation; Ketoconazole; Kinetics; Microsomes, Liver; Omeprazole; Quinidine; Substrate Specificity; Sulfuric Acid Esters; Theophylline; Triamterene	2005