Compounds > coumarin

coumarin and novobiocin

coumarin has been researched along with novobiocin in 17 studies

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (17.65)18.2507
2000's10 (58.82)29.6817
2010's4 (23.53)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Ali, JA; Maxwell, A; Orphanides, G1
Breeze, AL; Ladbury, JE; O'Brien, R; Pauptit, RA; Poyser, JP; Singh, OM; Skarzynski, T; Tsai, FT; Tucker, A; Weston, S; Wigley, DB; Wonacott, AJ1
Fournier, B; Hooper, DC1
Bishara, J; Blance, SJ; Maxwell, A; Preston, ZA; Smyth, MS; Williams, NL1
Chen, H; Walsh, CT1
Bonnefoy, A; Chatreaux, F; Ferreira, A; Klich, M; Loyau, V; Mauvais, P; Murer, M; Schio, L1
Domenici, E; Gevi, M1
Carvalho, DC; Garrido, SS; Marchetto, R; Scatigno, AC; Trovatti, E1
Allan, RK; Mok, D; Ratajczak, T; Ward, BK1
Blagg, BS; Huang, YT1
Feilmeier, BJ; Herberg, JT; McCroskey, MC; Miller, JR; Tomilo, M1
Atichartpongkul, S; Fuangthong, M; Mongkolsuk, S; Rangkadilok, N; Sallabhan, R; Satayavivad, J; Sriprang, R1
Blagg, BS; Burlison, JA; Donnelly, AC; Holzbeierlein, J; Mays, JR; Nelson, JT; Vielhauer, G1
Blagg, BS; Brown, D; Gu, W; Holzbeierlein, J; Khandelwal, A; Kusuma, BR; Liu, W; Vielhauer, G1
Blagg, BS; Byrd, KM; Cohen, MS; Holzbeierlein, J; Liu, W; Motiwala, HF; Sanchez, J; Subramanian, C1
Burley, GA; Chung, CH; Humphreys, LD; Mosley, JE; Sadler, JC1

Other Studies

17 other study(ies) available for coumarin and novobiocin

ArticleYear
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Nucleotide binding to the 43-kilodalton N-terminal fragment of the DNA gyrase B protein.
    Biochemistry, 1995, Aug-01, Volume: 34, Issue:30

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adenylyl Imidodiphosphate; Coumarins; Cross-Linking Reagents; Dimethyl Suberimidate; DNA Gyrase; DNA Topoisomerases, Type II; Escherichia coli; Kinetics; Macromolecular Substances; Novobiocin; Peptide Fragments; Trypsin

1995
The high-resolution crystal structure of a 24-kDa gyrase B fragment from E. coli complexed with one of the most potent coumarin inhibitors, clorobiocin.
    Proteins, 1997, Volume: 28, Issue:1

    Topics: Binding Sites; Coumarins; Crystallography, X-Ray; DNA Gyrase; DNA Topoisomerases, Type II; Escherichia coli; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Weight; Novobiocin; Protein Binding; Protein Conformation; Solutions; Structure-Activity Relationship; Thermodynamics

1997
Mutations in topoisomerase IV and DNA gyrase of Staphylococcus aureus: novel pleiotropic effects on quinolone and coumarin activity.
    Antimicrobial agents and chemotherapy, 1998, Volume: 42, Issue:1

    Topics: 4-Quinolones; Amino Acid Sequence; Anti-Bacterial Agents; Anti-Infective Agents; Anticoagulants; Coumarins; DNA Gyrase; DNA Topoisomerase IV; DNA Topoisomerases, Type II; Drug Resistance, Microbial; Molecular Sequence Data; Mutation; Novobiocin; Phenotype; Sequence Alignment; Sequence Homology, Amino Acid; Staphylococcus aureus

1998
Temperature-sensitive suppressor mutations of the Escherichia coli DNA gyrase B protein.
    Protein science : a publication of the Protein Society, 2000, Volume: 9, Issue:5

    Topics: Antibiotics, Antineoplastic; Coumarins; Crystallography, X-Ray; DNA Gyrase; DNA Topoisomerases, Type II; Drug Resistance, Neoplasm; Enzyme Inhibitors; Escherichia coli; Glycine; Models, Chemical; Models, Molecular; Mutagenesis, Site-Directed; Novobiocin; Phenotype; Protein Conformation; Suppression, Genetic; Temperature; Thermodynamics; Valine

2000
Coumarin formation in novobiocin biosynthesis: beta-hydroxylation of the aminoacyl enzyme tyrosyl-S-NovH by a cytochrome P450 NovI.
    Chemistry & biology, 2001, Volume: 8, Issue:4

    Topics: Acylation; Adenosine Triphosphate; Bacterial Proteins; Chromatography, High Pressure Liquid; Cloning, Molecular; Coumarins; Cytochrome P-450 Enzyme System; Genes, Bacterial; Hydroxylation; Novobiocin; Protein Processing, Post-Translational; Protein Structure, Tertiary; Recombinant Proteins; Stereoisomerism; Streptomyces

2001
Fine Tuning of physico-chemical parameters to optimise a new series of novobiocin analogues.
    Bioorganic & medicinal chemistry letters, 2001, Jun-04, Volume: 11, Issue:11

    Topics: Anti-Bacterial Agents; Coumarins; Microbial Sensitivity Tests; Novobiocin; Staphylococcus aureus

2001
A scintillation proximity assay amenable for screening and characterization of DNA gyrase B subunit inhibitors.
    Analytical biochemistry, 2002, Jan-01, Volume: 300, Issue:1

    Topics: Anti-Bacterial Agents; Binding Sites; Biotinylation; Coumarins; DNA Gyrase; Drug Evaluation, Preclinical; Enzyme Inhibitors; Escherichia coli; Novobiocin; Peptides, Cyclic; Radioligand Assay; Topoisomerase II Inhibitors

2002
Probing the binding of the coumarin drugs using peptide fragments of DNA gyrase B protein.
    The journal of peptide research : official journal of the American Peptide Society, 2005, Volume: 65, Issue:5

    Topics: Adenosine Triphosphate; Amino Acid Sequence; Arginine; Binding Sites; Binding, Competitive; Chromatography, Affinity; Coumarins; DNA Gyrase; Drug Design; Escherichia coli Proteins; Magnesium; Molecular Sequence Data; Novobiocin; Peptide Fragments

2005
Modulation of chaperone function and cochaperone interaction by novobiocin in the C-terminal domain of Hsp90: evidence that coumarin antibiotics disrupt Hsp90 dimerization.
    The Journal of biological chemistry, 2006, Mar-17, Volume: 281, Issue:11

    Topics: Alanine; Amino Acid Sequence; Aminocoumarins; Anti-Bacterial Agents; Binding Sites; Coumarins; Dimerization; DNA, Complementary; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Glutathione Transferase; HeLa Cells; HSP90 Heat-Shock Proteins; Humans; Immunophilins; Molecular Chaperones; Molecular Conformation; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Novobiocin; Plasmids; Point Mutation; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Steroids; Substrate Specificity; Tacrolimus Binding Proteins; Time Factors

2006
A library of noviosylated coumarin analogues.
    The Journal of organic chemistry, 2007, May-11, Volume: 72, Issue:10

    Topics: Boronic Acids; Coumarins; Databases, Factual; Esterification; HSP90 Heat-Shock Proteins; Iodobenzoates; Molecular Structure; Novobiocin; Structure-Activity Relationship

2007
Streptococcus pneumononiae gyrase ATPase: development and validation of an assay for inhibitor discovery and characterization.
    Analytical biochemistry, 2007, Jun-01, Volume: 365, Issue:1

    Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Anti-Bacterial Agents; Bacterial Proteins; Cloning, Molecular; Coumarins; DNA Gyrase; Drug Evaluation, Preclinical; Enzyme Inhibitors; Escherichia coli; Kinetics; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Novobiocin; Recombinant Proteins; Streptococcus pneumoniae; Topoisomerase II Inhibitors

2007
The omlA gene is involved in multidrug resistance and its expression is inhibited by coumarins in Xanthomonas campestris pv. phaseoli.
    Archives of microbiology, 2008, Volume: 189, Issue:3

    Topics: Aminocoumarins; Anti-Bacterial Agents; Bacterial Outer Membrane Proteins; Base Sequence; Chloramphenicol; Coumarins; DNA, Bacterial; Drug Resistance, Multiple, Bacterial; Gene Expression; Lipoproteins; Microbial Sensitivity Tests; Molecular Sequence Data; Mutagenesis, Insertional; Novobiocin; Promoter Regions, Genetic; Sodium Dodecyl Sulfate; Transcription Initiation Site; Transcription, Genetic; Vitamin K 3; Xanthomonas campestris

2008
The design, synthesis, and evaluation of coumarin ring derivatives of the novobiocin scaffold that exhibit antiproliferative activity.
    The Journal of organic chemistry, 2008, Nov-21, Volume: 73, Issue:22

    Topics: Cell Line, Tumor; Cell Proliferation; Coumarins; Drug Design; Humans; Naphthalenes; Novobiocin; Quinolines

2008
Synthesis and biological evaluation of coumarin replacements of novobiocin as Hsp90 inhibitors.
    Bioorganic & medicinal chemistry, 2014, Feb-15, Volume: 22, Issue:4

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Coumarins; HSP90 Heat-Shock Proteins; Humans; MCF-7 Cells; Naphthalenes; Novobiocin; Protein Binding; Quinolines

2014
Synthesis and Biological Evaluation of Novobiocin Core Analogues as Hsp90 Inhibitors.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2016, 05-10, Volume: 22, Issue:20

    Topics: Aminocoumarins; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Chemistry Techniques, Synthetic; Coumarins; Drug Screening Assays, Antitumor; HSP90 Heat-Shock Proteins; Humans; Molecular Structure; Novobiocin; Structure-Activity Relationship

2016
Structural and Functional Basis of C-Methylation of Coumarin Scaffolds by NovO.
    ACS chemical biology, 2017, 02-17, Volume: 12, Issue:2

    Topics: Catalysis; Coumarins; Crystallography, X-Ray; Methylation; Methyltransferases; Molecular Structure; Novobiocin; Streptomyces; Substrate Specificity

2017