coumarin and 7-hydroxycoumarin

coumarin has been researched along with 7-hydroxycoumarin in 94 studies

Research

Studies (94)

Timeframe	Studies, this research(%)	All Research%
pre-1990	11 (11.70)	18.7374
1990's	29 (30.85)	18.2507
2000's	26 (27.66)	29.6817
2010's	24 (25.53)	24.3611
2020's	4 (4.26)	2.80

Authors

Authors	Studies
Enriz, RD; Giordano, OS; Jáuregui, EA; Pestchanker, MJ; Rodríguez, AM; Santagata, LN	1
Abeygunawardana, C; Dinkova-Kostova, AT; Talalay, P	1
Bohlin, L; Huss, U; Perera, P; Ringbom, T; Vasänge, M	1
Bories, C; Gleye, C; Hocquemiller, R; Jullian, JC; Laurens, A; Lewin, G; Loiseau, P	1
Andricopulo, AD; da Silva, MF; de Marchi, AA; de Souza, MC; Ferreira, VF; Leitão, A; Montanari, CA; Moraes, VR; Oliva, G; Pupo, MT; Sá, MM; Vieira, PC	1
Hadjipavlou-Litina, DJ; Kontogiorgis, CA	1
Chamilos, M; Hadjipavlou-Litina, DJ; Kallitsakis, M; Litinas, KE; Symeonidis, T	1
Andricopulo, AD; Freitas, RF; Montanari, CA; Oliva, G; Prokopczyk, IM; Silva, MG; Trevisan, MT; Vilegas, W; Zottis, A	1
Maresca, A; Supuran, CT	1
Adachi, I; Hirono, S; Kato, A; Kobayashi, K; Minoshima, Y; Narukawa, K; Nash, RJ	1
Maresca, A; Scozzafava, A; Supuran, CT	1
Dedhar, S; Lou, Y; Maresca, A; McDonald, PC; Scozzafava, A; Supuran, CT; Touisni, N; Winum, JY	1
Marumoto, S; Miyazawa, M	1
Battastini, AM; Bernardi, A; Eifler-Lima, VL; Figueiró, F; Hamerski, L; Pinto, AC; Pires, EN; Salbego, CG; Teixeira, HF; Vianna, DR; Visentin, LC; von Poser, GL	1
Barbosa-Filho, JM; de Aquino, TM; de Araújo, RS; de Moura, RO; de O Lima, E; de Simone, CA; Guerra, FQ; Mendonça, FJ; Scotti, L; Scotti, MT; Tavares, JF	1
Carta, F; Ferraroni, M; Scozzafava, A; Supuran, CT	1
Haranahalli, K; Ojima, I; Tong, S	1
Calil, FA; Chibli, LA; Da Costa, FB; Nonato, MC; Schmidt, TJ	1
Ge, GB; Gonzalez, FJ; Li, SY; Liu, Y; Wang, JJ; Wang, P; Xia, YL	1
Kojo, A; Kraul, H; Pelkonen, O; Rautio, A; Salmela, E	1
Fentem, JH; Fry, JR	1
Baumgartner, G; Stuhlmeier, K; Theyer, G; Zlabinger, GJ	1
Coe, SA; Khazanchi, RK; Knight, KR; McCann, JJ; O'Brien, BM; Pederson, WC	1
Gallicchio, VS; Harmon, C; Hulette, BC; Marshall, ME	1
Kada, T; Moriya, M; Ohta, T; Shirasu, Y; Watanabe, K	1
Ritschel, WA	1
Hardt, T; Ritschel, WA	1
Hardt, TJ; Ritschel, WA	4
Albainy-Jenei, S; Benefield, C; Kervin, K; Khazaeli, MB; Marshall, ME; Umerani, A; Zhao, Q	1
Arvela, P; Bäckstrom, M; Pelkonen, O; Rautio, A; Sotaniemi, EA	1
Beamand, JA; Esclangon, F; Lake, BG; Price, RJ; Renwick, AB; Walters, DG; Wield, PT	1
Böhmig, GA; Menzel, JE; Nöhammer, C; Zlabinger, GJ	1
Deasy, B; Dempsey, E; Egan, DA; O'Kennedy, R; Smyth, MR	1
Hakkola, J; Mäenpää, J; Pelkonen, O; Raunio, H; Rautio, A	1
Bueschen, A; Butler, K; Edmonds, K; Markiewicz, M; Marshall, ME; Mohler, JL; Ryles, M; Urban, D; Weiss, L; Williams, B	1
Maucher, A; von Angerer, E	1
Legrum, W; Runkel, M; Tegtmeier, M	1
Bogan, DP; Killard, AJ; O'Kennedy, R	1
Bogan, DP; O'Kennedy, R	1
Biour, M; Gersberg, M; Guédès, Y; Lamiable, D; Leutenegger, E; Ratanasavanh, D; Riché, C	1
Draper, AJ; Madan, A; Parkinson, A	1
Bogan, DP; Deasy, B; O'Kennedy, R; Smyth, MR	1
Jarema, MA; Lee, JS; Street, JC	1
Pasanen, M; Pelkonen, O; Rannala, Z; Rautio, A; Sotaniemi, EA; Tooming, A	1
Bourian, M; Legrum, W; Runkel, M; Tegtmeier, M	1
Bantle, JA; Fort, DJ; Hull, MA; Propst, T; Stover, EL	1
Siegers, CP; Steffen, B; Weber, US	1
Lü, HQ; Niggemann, B; Schmitz, U; Zänker, KS	1
Baxter, PJ; Hankins, DC; Kharasch, ED; Thummel, KE	1
Brunsvik, A; Cholerton, S; Hadidi, H; Idle, JR; Irshaid, Y; Vågbø, CB; Zahlsen, K	1
Duffy, CF; O'Kennedy, R	1
Bourian, M; Freudenstein, J; Krisp, A; Legrum, W; Runkel, M; Tegtmeier, M	1
Hankins, DC; Kharasch, ED; Taraday, JK	1
Aygün Kocabaş, N; Cholerton, S; Cok, I; Karakaya, AE; Sardaş, S	1
Guengerich, FP; Martin, MV; Nakamura, K	1
Elizalde-Galvan, P; García-Mondragón, MJ; Jiménez-Orozco, FA; León-Cedeño, F; López-González, JS; Mandoki, JJ; Mendoza-Patiño, N; Molina-Guarneros, JA; Nieto-Rodriguez, A; Velasco-Velázquez, MA	1
Keener, WK; Miller, AR; Roberto, FF; Watwood, ME	1
Han, XM; Huang, SL; Xu, P; Zhou, HH; Zhu, RH	1
Api, AM; Born, SL; Ford, RA; Hawkins, DR; Lefever, FR	1
MEAD, JA; SMITH, JN; WILLIAMS, RT	1
HAAG-BERRURIER, M	1
Baker, JR; Moore, MR; Nishijo, M; Satarug, S; Ujjin, P; Vanavanitkun, Y	1
Aguilar-Cazares, D; Lopez-Gonzalez, JS; Mandoki, JJ; Molina-Guarneros, JA; Morales-Fuentes, J; Prado-Garcia, H	1
Ding, X; He, XY; Hong, JY; Hu, WY; Lu, AY; Shen, J	1
Cui, H; D'Agostino, J; Ding, X; Gu, J; Su, T; Swiatek, PJ; Yang, W; Zhang, QY; Zhang, X; Zhuo, X	1
Iancov, I; Michailova, A; Mitov, I; Neychev, H; Nikolova, N; Stefanova, T; Zlabinger, GJ	1
Fujieda, M; Kamataki, T; Kiyotani, K; Peamkrasatam, S; Sriwatanakul, K; Yamazaki, H; Yoovathaworn, K	1
Neychev, HO; Nikolova, NJ; Stefanova, TH; Toshkova, RA	1
Ashton, M; Asimus, S; Hai, TN; Van Huong, N	1
Guan, H; Tang, H; Zhou, H; Zhu, L	1
Boersma, MG; Punt, A; Rietjens, IM; Zaleska, M	1
Basiaga, SB; Hage, DS; Joseph, KS; Moser, AC; Schiel, JE	1
Coffigny, H; Hanedanian, M; Louit, G; Pin, S; Renault, JP; Taran, F	1
Abbas, ME; Li, K; Li, W; Liu, S; Luo, W; Tang, H; Zhou, W; Zhu, L	1
Ahn, T; Jung, HC; Kim, D; Kim, DH; Pan, JG; Park, SH; Yun, CH	1
Ismail, R; Ong, CE; Tan, EL; Tiong, KH; Yiap, BC	1
Adfa, M; Koketsu, M; Komura, K; Yoshimura, T	1
Abraham, K; Lampen, A; Pfister, M; Wöhrlin, F	1
Chen, T; Lee, LW; Lin, MH; Lin, PY; Ou, KL; Sheu, SY; Su, CL; Yeh, KS	1
Borbas, KE; Ilchenko, NO; Pershagen, E; Szíjjártó, C	1
Dai, J; Kim, JC	1
Buckup, T; Krauter, CM; Möhring, J; Motzkus, M; Pernpointner, M	1
Campos, FR; Cerqueira, LB; de Francisco, TM; Gasparetto, JC; Peccinini, RG; Pontarolo, R	1
Bailey, A; Callis, R; De Savi, C; Degorce, SL; Ducray, R; Lamont, G; MacFaul, P; Martin, S; Maudet, M; Morgentin, R; Norman, RA; Peru, A; Pink, JH; Plé, PA; Roberts, B; Scott, JS	1
Barbosa-Filho, JM; de Araujo Leite, JC; de Castro, TM; de Siqueira-Junior, JP; Marques-Santos, LF	1
Liu, H; Shen, JZ; Zhang, HX	1
Hirano, K; Kobayashi, T	1
Hirasawa, N; Hiratsuka, M; Hosono, H; Kumondai, M; Maekawa, M; Mano, N; Oda, A; Yamaguchi, H	1
Hina, S; Kamiya, Y; Kobayashi, Y; Miura, T; Murayama, N; Shimizu, M; Yamazaki, H	1
Jakubowicz-Gil, J; Langner, E; Maciejczyk, A; Rzeski, W; Skalicka-Woźniak, K; Sumorek-Wiadro, J; Zając, A	1
Byun, HS; Hur, GM; Ju, E; Lee, J; Lee, SR; Na, M; Park, KA; Piao, X; Quan, KT; Sohn, KC	1

Reviews

3 review(s) available for coumarin and 7-hydroxycoumarin

Article	Year
Recent advances in the discovery and development of antibacterial agents targeting the cell-division protein FtsZ. Bioorganic & medicinal chemistry, 2016, 12-15, Volume: 24, Issue:24 Topics: Anti-Bacterial Agents; Bacteria; Bacterial Proteins; Cytoskeletal Proteins; Drug Discovery; Humans; Microbial Sensitivity Tests; Structure-Activity Relationship	2016
Regulation of coumarin 7-hydroxylation in man. Journal of cancer research and clinical oncology, 1994, Volume: 120 Suppl Topics: Animals; Aryl Hydrocarbon Hydroxylases; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Humans; Hydroxylation; Liver; Liver Diseases; Mice; Mixed Function Oxygenases; Prodrugs; Umbelliferones	1994
An updated review of the clinical development of coumarin (1,2-benzopyrone) and 7-hydroxycoumarin. Journal of cancer research and clinical oncology, 1994, Volume: 120 Suppl Topics: Adult; Aged; Carcinoma, Renal Cell; Chemotherapy, Adjuvant; Cimetidine; Coumarins; Drug Therapy, Combination; Female; Humans; Kidney Neoplasms; Male; Middle Aged; Survival Analysis; Treatment Outcome; Umbelliferones	1994

Trials

6 trial(s) available for coumarin and 7-hydroxycoumarin

Article	Year
Single-dose disulfiram does not inhibit CYP2A6 activity. Clinical pharmacology and therapeutics, 1998, Volume: 64, Issue:1 Topics: Administration, Oral; Adult; Antineoplastic Agents; Aryl Hydrocarbon Hydroxylases; Coumarins; Cross-Over Studies; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Disulfiram; Double-Blind Method; Enzyme Inhibitors; Female; Humans; Male; Mixed Function Oxygenases; Umbelliferones	1998
Naringenin and interindividual variability in interaction of coumarin with grapefruit juice. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 1999, Volume: 51, Issue:4-5 Topics: Adult; Aryl Hydrocarbon Hydroxylases; Beverages; Citrus; Coumarins; Cross-Over Studies; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Flavanones; Flavonoids; Genotype; Humans; Kinetics; Male; Mixed Function Oxygenases; Scopoletin; Umbelliferones	1999
Single-dose methoxsalen effects on human cytochrome P-450 2A6 activity. Drug metabolism and disposition: the biological fate of chemicals, 2000, Volume: 28, Issue:1 Topics: Administration, Oral; Adult; Analysis of Variance; Anticoagulants; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Coumarins; Cross-Over Studies; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Female; Humans; Male; Methoxsalen; Mixed Function Oxygenases; Molecular Probes; Umbelliferones	2000
In vivo evaluation of coumarin and nicotine as probe drugs to predict the metabolic capacity of CYP2A6 due to genetic polymorphism in Thais. Drug metabolism and pharmacokinetics, 2006, Volume: 21, Issue:6 Topics: Administration, Oral; Adolescent; Adult; Anticoagulants; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cotinine; Coumarins; Cytochrome P-450 CYP2A6; Drug Combinations; Female; Gene Frequency; Genotype; Humans; Hydroxyethylrutoside; Male; Middle Aged; Mixed Function Oxygenases; Nicotine; Nicotinic Agonists; Phenotype; Polymethacrylic Acids; Polymorphism, Genetic; Polyvinyls; Thailand; Tobacco Use Cessation Devices; Umbelliferones	2006
Artemisinin and CYP2A6 activity in healthy subjects. European journal of clinical pharmacology, 2008, Volume: 64, Issue:3 Topics: Adult; Antimalarials; Area Under Curve; Artemisinins; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Chromatography, Liquid; Coumarins; Cross-Over Studies; Cytochrome P-450 CYP2A6; Enzyme Induction; Humans; Male; Mixed Function Oxygenases; Nicotine; Tandem Mass Spectrometry; Umbelliferones; Vietnam	2008
Relative bioavailability of coumarin from cinnamon and cinnamon-containing foods compared to isolated coumarin: a four-way crossover study in human volunteers. Molecular nutrition & food research, 2011, Volume: 55, Issue:4 Topics: Adult; Beverages; Capsules; Cinnamomum aromaticum; Coumarins; Cross-Over Studies; Female; Food; Glucuronides; Humans; Intestinal Absorption; Kinetics; Male; Middle Aged; Plant Bark; Powders; Risk Assessment; Spices; Umbelliferones	2011

Other Studies

85 other study(ies) available for coumarin and 7-hydroxycoumarin

Article	Year
Structure-cytoprotective activity relationship of simple molecules containing an alpha,beta-unsaturated carbonyl system. Journal of medicinal chemistry, 1997, Jun-06, Volume: 40, Issue:12 Topics: 4-Butyrolactone; Animals; Anti-Ulcer Agents; Chemical Phenomena; Chemistry, Physical; Cyclization; Cyclopentanes; Electrochemistry; Male; Models, Molecular; Molecular Conformation; Molecular Structure; Rats; Rats, Wistar; Stomach Ulcer; Structure-Activity Relationship	1997
Chemoprotective properties of phenylpropenoids, bis(benzylidene)cycloalkanones, and related Michael reaction acceptors: correlation of potencies as phase 2 enzyme inducers and radical scavengers. Journal of medicinal chemistry, 1998, Dec-17, Volume: 41, Issue:26 Topics: Animals; Anticarcinogenic Agents; Chalcone; Cinnamates; Coumarins; Enzyme Induction; Free Radical Scavengers; Liver Neoplasms, Experimental; Luminescent Measurements; Magnetic Resonance Spectroscopy; Mice; Molecular Conformation; NAD(P)H Dehydrogenase (Quinone); Structure-Activity Relationship; Superoxides; Tumor Cells, Cultured	1998
Screening of ubiquitous plant constituents for COX-2 inhibition with a scintillation proximity based assay. Journal of natural products, 2002, Volume: 65, Issue:11 Topics: Acrolein; Alkaloids; Animals; Anthraquinones; Aspirin; Biological Assay; Catalysis; Cinnamomum zeylanicum; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Eugenol; Flavonoids; Indomethacin; Inhibitory Concentration 50; Isoenzymes; Kinetics; Lactones; Models, Molecular; Nitrobenzenes; Oleanolic Acid; Plants, Medicinal; Prostaglandin-Endoperoxide Synthases; Pyrogallol; Steroids; Sulfonamides; Sulfones; Syzygium; Terpenes; Triterpenes; Ursolic Acid	2002
Acaricidal activity of tonka bean extracts. Synthesis and structure-activity relationships of bioactive derivatives. Journal of natural products, 2003, Volume: 66, Issue:5 Topics: Animals; Coumarins; Dermatophagoides pteronyssinus; Dust; Fabaceae; France; Insecticides; Nuclear Magnetic Resonance, Biomolecular; Plants, Medicinal; Structure-Activity Relationship	2003
Structure-activity relationships of novel inhibitors of glyceraldehyde-3-phosphate dehydrogenase. Bioorganic & medicinal chemistry letters, 2004, May-03, Volume: 14, Issue:9 Topics: Enzyme Inhibitors; Glyceraldehyde 3-Phosphate Dehydrogenase (NADP+); Quantitative Structure-Activity Relationship	2004
Synthesis and antiinflammatory activity of coumarin derivatives. Journal of medicinal chemistry, 2005, Oct-06, Volume: 48, Issue:20 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Coumarins; Cyclooxygenase Inhibitors; Edema; Female; Free Radical Scavengers; Immunologic Factors; Lipoxygenase Inhibitors; Male; Mannich Bases; Rats; Rats, Inbred F344; Structure-Activity Relationship; Superoxides	2005
Synthesis of hydroxycoumarins and hydroxybenzo[f]- or [h]coumarins as lipid peroxidation inhibitors. Bioorganic & medicinal chemistry letters, 2009, Feb-15, Volume: 19, Issue:4 Topics: Animals; Antioxidants; Biphenyl Compounds; Combinatorial Chemistry Techniques; Coumarins; Edema; Lipid Peroxidation; Microwaves; Molecular Structure; Picrates; Rats	2009
Discovery of novel Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase inhibitors. Bioorganic & medicinal chemistry, 2009, Mar-15, Volume: 17, Issue:6 Topics: Animals; Enzyme Inhibitors; Glyceraldehyde-3-Phosphate Dehydrogenases; Kinetics; Models, Molecular; Spectrophotometry, Ultraviolet; Thermodynamics; Trypanosoma cruzi	2009
Coumarins incorporating hydroxy- and chloro-moieties selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II. Bioorganic & medicinal chemistry letters, 2010, Aug-01, Volume: 20, Issue:15 Topics: Antigens, Neoplasm; Binding Sites; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Carbonic Anhydrases; Computer Simulation; Coumarins; Humans; Neoplasms	2010
6,7-Dihydroxy-4-phenylcoumarin as inhibitor of aldose reductase 2. Bioorganic & medicinal chemistry letters, 2010, Oct-01, Volume: 20, Issue:19 Topics: Aldehyde Reductase; Animals; Binding Sites; Computer Simulation; Coumarins; Galactitol; L-Iditol 2-Dehydrogenase; Lens, Crystalline; Protein Structure, Tertiary; Rats; Rhodanine; Structure-Activity Relationship; Thiazolidines	2010
7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range. Bioorganic & medicinal chemistry letters, 2010, Dec-15, Volume: 20, Issue:24 Topics: Antigens, Neoplasm; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Carbonic Anhydrases; Cell Membrane; Coumarins; Humans; Neoplasms; Protein Isoforms; Structure-Activity Relationship	2010
Glycosyl coumarin carbonic anhydrase IX and XII inhibitors strongly attenuate the growth of primary breast tumors. Journal of medicinal chemistry, 2011, Dec-22, Volume: 54, Issue:24 Topics: Animals; Antigens, Neoplasm; Antineoplastic Agents; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Carbonic Anhydrases; Cell Hypoxia; Coumarins; Female; Humans; Mice; Mice, Inbred BALB C; Structure-Activity Relationship; Xenograft Model Antitumor Assays	2011
Structure-activity relationships for naturally occurring coumarins as β-secretase inhibitor. Bioorganic & medicinal chemistry, 2012, Jan-15, Volume: 20, Issue:2 Topics: 5-Methoxypsoralen; Amyloid Precursor Protein Secretases; Coumarins; Furocoumarins; Kinetics; Methoxsalen; Protease Inhibitors; Structure-Activity Relationship	2012
Selective cytotoxicity and apoptosis induction in glioma cell lines by 5-oxygenated-6,7-methylenedioxycoumarins from Pterocaulon species. European journal of medicinal chemistry, 2012, Volume: 57 Topics: Animals; Antineoplastic Agents; Apoptosis; Asteraceae; Benzodioxoles; Cell Line, Tumor; Cell Survival; Central Nervous System Neoplasms; Coumarins; Cytotoxins; Glioma; Hippocampus; Humans; Hydrogen Bonding; Inhibitory Concentration 50; Male; Organ Specificity; Rats; Rats, Wistar; Structure-Activity Relationship; Tissue Culture Techniques	2012
Synthesis, structure-activity relationships (SAR) and in silico studies of coumarin derivatives with antifungal activity. International journal of molecular sciences, 2013, Jan-10, Volume: 14, Issue:1 Topics: Acetylation; Alkylation; Antifungal Agents; Aspergillus; Computer Simulation; Coumarins; Least-Squares Analysis; Microbial Sensitivity Tests; Models, Chemical; Models, Molecular; Molecular Structure; Nitrates; Principal Component Analysis; Structure-Activity Relationship	2013
Thioxocoumarins Show an Alternative Carbonic Anhydrase Inhibition Mechanism Compared to Coumarins. Journal of medicinal chemistry, 2016, Jan-14, Volume: 59, Issue:1 Topics: Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Coumarins; Crystallography, X-Ray; Humans; Isoenzymes; Models, Molecular; Molecular Structure; Structure-Activity Relationship	2016
Natural products as inhibitors of Leishmania major dihydroorotate dehydrogenase. European journal of medicinal chemistry, 2018, Sep-05, Volume: 157 Topics: Biological Products; Calorimetry, Differential Scanning; Dihydroorotate Dehydrogenase; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Lactones; Leishmania major; Models, Molecular; Molecular Structure; Oxidoreductases Acting on CH-CH Group Donors; Quantitative Structure-Activity Relationship; Sesquiterpenes	2018
Synthesis and structure-activity relationship of coumarins as potent Mcl-1 inhibitors for cancer treatment. Bioorganic & medicinal chemistry, 2021, 01-01, Volume: 29 Topics: A549 Cells; Antineoplastic Agents; Cell Proliferation; Cell Survival; Coumarins; Dose-Response Relationship, Drug; Humans; Models, Molecular; Molecular Structure; Myeloid Cell Leukemia Sequence 1 Protein; Structure-Activity Relationship; Tumor Cells, Cultured	2021
Interindividual variability of coumarin 7-hydroxylation in healthy volunteers. Pharmacogenetics, 1992, Volume: 2, Issue:5 Topics: Adult; Aryl Hydrocarbon Hydroxylases; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Female; Genetic Variation; Humans; Hydroxylation; Kinetics; Male; Middle Aged; Mixed Function Oxygenases; Reference Values; Reproducibility of Results; Umbelliferones	1992
Effect of cimetidine on the metabolism of coumarin by rat, gerbil and human liver microsomes. Biochemical pharmacology, 1991, Sep-12, Volume: 42, Issue:7 Topics: Animals; Cimetidine; Coumarins; Drug Interactions; Gerbillinae; Humans; Male; Microsomes, Liver; Models, Biological; Phenobarbital; Rats; Rats, Inbred Strains; Umbelliferones	1991
Synergistic effect of coumarin (1,2 benzopyrone) and endotoxin in the induction of human interleukin-1. Clinical and experimental immunology, 1991, Volume: 84, Issue:2 Topics: 4-Hydroxycoumarins; Biological Assay; Cells, Cultured; Coumarins; Dose-Response Relationship, Drug; Drug Synergism; Endotoxins; Humans; In Vitro Techniques; Interleukin-1; Interleukin-6; Leukocytes, Mononuclear; Tumor Necrosis Factor-alpha; Umbelliferones	1991
Coumarin and 7-hydroxycoumarin treatment of canine obstructive lymphoedema. Clinical science (London, England : 1979), 1989, Volume: 77, Issue:1 Topics: Animals; Coumarins; Dogs; Endopeptidases; Hindlimb; Lymph; Lymphedema; Proteins; Skin; Umbelliferones	1989
Toxicity of coumarin (1,2-benzopyrone) on human peripheral blood mononuclear cells and human and murine bone marrow progenitor stem cells. Journal of biological response modifiers, 1989, Volume: 8, Issue:2 Topics: Animals; Bone Marrow; Bone Marrow Cells; Cells, Cultured; Coumarins; Humans; Leukocytes, Mononuclear; Male; Mice; Stem Cells; Umbelliferones	1989
Anti-mutagenic effects of coumarin and umbelliferone on mutagenesis induced by 4-nitroquinoline 1-oxide or UV irradiation in E. coli. Mutation research, 1983, Volume: 117, Issue:1-2 Topics: 4-Nitroquinoline-1-oxide; Coumarins; Escherichia coli; Mutagens; Mutation; Nitroquinolines; Structure-Activity Relationship; Ultraviolet Rays; Umbelliferones	1983
Therapeutic concentration of coumarin and predicted dosage regimens. Arzneimittel-Forschung, 1984, Volume: 34, Issue:8 Topics: Adult; Computers; Coumarins; Delayed-Action Preparations; Episiotomy; Female; Humans; Injections, Intravenous; Models, Biological; Umbelliferones	1984
Tissue distribution of coumarin, 7-hydroxycoumarin and their 7-hydroxy metabolites following parenteral administration of 14C-labeled compound in the DBA/lac mouse. Arzneimittel-Forschung, 1983, Volume: 33, Issue:6 Topics: Animals; Coumarins; Kinetics; Male; Mice; Mice, Inbred DBA; Models, Biological; Tissue Distribution; Umbelliferones	1983
Pharmacokinetics of coumarin, 7-hydroxycoumarin and 7-hydroxycoumarin glucuronide in the blood and brain of gerbils following intraperitoneal administration of coumarin. Arzneimittel-Forschung, 1983, Volume: 33, Issue:9 Topics: Animals; Brain; Coumarins; Esculin; Flavonoids; Gerbillinae; Injections, Intraperitoneal; Kinetics; Male; Umbelliferones	1983
Dose-related pharmacokinetics of coumarin, 7-hydroxycoumarin and 7-hydroxycoumarin glucuronide upon intraperitoneal administration of coumarin and 7-hydroxycoumarin in the rat. Arzneimittel-Forschung, 1983, Volume: 33, Issue:10 Topics: Animals; Coumarins; Dose-Response Relationship, Drug; Half-Life; Injections, Intraperitoneal; Kinetics; Rats; Rats, Inbred Strains; Umbelliferones	1983
Investigation of the dose-response relationship upon intraperitoneal administration of coumarin and 7-hydroxycoumarin on the carrageenan induced edema of the rat hind paw. Arzneimittel-Forschung, 1983, Volume: 33, Issue:12 Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Coumarins; Dose-Response Relationship, Drug; Edema; Injections, Intraperitoneal; Rats; Rats, Inbred Strains; Umbelliferones	1983
The effect of coumarin and 7-hydroxycoumarin on in vitro macrophage phagocytosis of latex particles. Methods and findings in experimental and clinical pharmacology, 1983, Volume: 5, Issue:1 Topics: Animals; Coumarins; In Vitro Techniques; Latex; Macrophages; Mice; Phagocytosis; Umbelliferones	1983
Growth-inhibitory effects of coumarin (1,2-benzopyrone) and 7-hydroxycoumarin on human malignant cell lines in vitro. Journal of cancer research and clinical oncology, 1994, Volume: 120 Suppl Topics: Apoptosis; Cell Division; Cell Survival; Coumarins; DNA, Neoplasm; Dose-Response Relationship, Drug; Humans; Prostate-Specific Antigen; Protein Biosynthesis; Proteins; RNA, Neoplasm; Time Factors; Tumor Cells, Cultured; Umbelliferones	1994
CYP3A4 and CYP2A6 activities marked by the metabolism of lignocaine and coumarin in patients with liver and kidney diseases and epileptic patients. British journal of clinical pharmacology, 1995, Volume: 39, Issue:1 Topics: Administration, Oral; Adult; Aged; Aryl Hydrocarbon Hydroxylases; Capsules; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Epilepsy; Female; Humans; Injections, Intravenous; Isoenzymes; Kidney Diseases; Kidney Function Tests; Lidocaine; Liver; Liver Diseases, Alcoholic; Liver Function Tests; Male; Middle Aged; Mixed Function Oxygenases; Peptide Fragments; Procollagen; Umbelliferones	1995
Comparison of the metabolism of 7-ethoxycoumarin and coumarin in precision-cut rat liver and lung slices. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1995, Volume: 33, Issue:3 Topics: Animals; Coumarins; Culture Techniques; Glucuronates; Glucuronic Acid; Isotope Labeling; Liver; Lung; Male; Rats; Rats, Sprague-Dawley; Sulfates; Umbelliferones	1995
Mode of action of coumarin in immune cells. Journal of cancer research and clinical oncology, 1994, Volume: 120 Suppl Topics: Binding Sites; Binding, Competitive; Cell Adhesion; Cells, Cultured; Coumarins; Humans; Monocytes; Umbelliferones	1994
Antibody-based approaches to coumarin analysis. Journal of cancer research and clinical oncology, 1994, Volume: 120 Suppl Topics: Animals; Antibodies; Antibody Specificity; Antigen-Antibody Reactions; Binding, Competitive; Chromatography, High Pressure Liquid; Coumarins; Electrochemistry; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Humans; Male; Ovalbumin; Rabbits; Serum Albumin, Bovine; Thyroglobulin; Umbelliferones	1994
Antitumour activity of coumarin and 7-hydroxycoumarin against 7,12-dimethylbenz[a]anthracene-induced rat mammary carcinomas. Journal of cancer research and clinical oncology, 1994, Volume: 120, Issue:8 Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Coumarins; Drug Evaluation, Preclinical; Female; Mammary Neoplasms, Experimental; Rats; Rats, Sprague-Dawley; Tamoxifen; Time Factors; Umbelliferones	1994
Metabolic and analytical interactions of grapefruit juice and 1,2-benzopyrone (coumarin) in man. European journal of clinical pharmacology, 1996, Volume: 50, Issue:3 Topics: Anticoagulants; Antioxidants; Beverages; Chromatography, High Pressure Liquid; Citrus; Coumarins; Flavanones; Flavonoids; Fluorescence; Food-Drug Interactions; Humans; Male; Umbelliferones	1996
Analysis of the glucuronidation of 7-hydroxycoumarin by HPLC. Journal of pharmaceutical and biomedical analysis, 1996, Volume: 14, Issue:11 Topics: Animals; Cattle; Chromatography, High Pressure Liquid; Coumarins; Glucuronosyltransferase; In Vitro Techniques; Liver; Umbelliferones	1996
Simultaneous determination of coumarin, 7-hydroxycoumarin and 7-hydroxycoumarin glucuronide in human serum and plasma by high-performance liquid chromatography. Journal of chromatography. B, Biomedical applications, 1996, Nov-15, Volume: 686, Issue:2 Topics: Chromatography, High Pressure Liquid; Coumarins; Humans; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Umbelliferones	1996
Metabolism and toxicity of coumarin on cultured human, rat, mouse and rabbit hepatocytes. Fundamental & clinical pharmacology, 1996, Volume: 10, Issue:6 Topics: 4-Hydroxycoumarins; Aged; Animals; Cells, Cultured; Child; Coumaric Acids; Coumarins; Dose-Response Relationship, Drug; Humans; L-Lactate Dehydrogenase; Liver; Mice; Mice, Inbred DBA; Middle Aged; Phenylacetates; Rabbits; Rats; Rats, Sprague-Dawley; Umbelliferones	1996
Inhibition of coumarin 7-hydroxylase activity in human liver microsomes. Archives of biochemistry and biophysics, 1997, May-01, Volume: 341, Issue:1 Topics: Adult; Aryl Hydrocarbon Hydroxylases; Child, Preschool; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dioxanes; Enzyme Inhibitors; Female; Furans; Humans; Hydroxylation; Kinetics; Male; Microsomes, Liver; Middle Aged; Mixed Function Oxygenases; Solvents; Umbelliferones	1997
Interspecies differences in coumarin metabolism in liver microsomes examined by capillary electrophoresis. Xenobiotica; the fate of foreign compounds in biological systems, 1996, Volume: 26, Issue:4 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Electrophoresis, Capillary; Humans; Kinetics; Mammals; Microsomes, Liver; Mixed Function Oxygenases; NADP; Species Specificity; Umbelliferones	1996
Study of coumarin metabolism by Chinese hamster lung fibroblasts expressing a human cytochrome P450 using H-nmr. Xenobiotica; the fate of foreign compounds in biological systems, 1996, Volume: 26, Issue:4 Topics: Animals; Cell Line; Coumarins; Cricetinae; Cricetulus; Culture Media; Cytochrome P-450 Enzyme System; Humans; Magnetic Resonance Spectroscopy; Umbelliferones; Xenobiotics	1996
Hepatitis A impairs the function of human hepatic CYP2A6 in vivo. Toxicology, 1997, Dec-05, Volume: 123, Issue:3 Topics: Adolescent; Adult; Anticoagulants; Aryl Hydrocarbon Hydroxylases; Child; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Female; gamma-Glutamyltransferase; Hepatitis A; Humans; Liver; Liver Function Tests; Male; Mixed Function Oxygenases; Transaminases; Umbelliferones	1997
The character of inhibition of the metabolism of 1,2-benzopyrone (coumarin) by grapefruit juice in human. European journal of clinical pharmacology, 1997, Volume: 53, Issue:3-4 Topics: Anticoagulants; Beverages; Citrus; Coumarins; Cross-Over Studies; Dose-Response Relationship, Drug; Flavanones; Flavonoids; Humans; Male; Umbelliferones	1997
Evaluation of the developmental toxicities of coumarin, 4-hydroxycoumarin, and 7-hydroxycoumarin using FETAX. Drug and chemical toxicology, 1998, Volume: 21, Issue:1 Topics: 4-Hydroxycoumarins; Abnormalities, Drug-Induced; Animals; Biotransformation; Coumarins; Cyclophosphamide; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Umbelliferones; Xenopus	1998
Antitumor-activities of coumarin, 7-hydroxy-coumarin and its glucuronide in several human tumor cell lines. Research communications in molecular pathology and pharmacology, 1998, Volume: 99, Issue:2 Topics: Antineoplastic Agents; Caco-2 Cells; Carcinoma, Hepatocellular; Coumarins; Dose-Response Relationship, Drug; Growth Inhibitors; Humans; Leukemia, Lymphoid; Liver Neoplasms; Stomach Neoplasms; Tumor Cells, Cultured; Umbelliferones	1998
Computer-assisted molecular design for the determination of structure-activity relationships for chemopreventive agents. Annals of the New York Academy of Sciences, 1997, Dec-29, Volume: 833 Topics: Antineoplastic Agents; Carcinoma; Cell Division; Cell Movement; Chemoprevention; Computer-Aided Design; Coumarins; Drug Design; Guanine; Guanosine Triphosphate; Humans; Molecular Structure; Point Mutation; Protein Binding; Proto-Oncogene Proteins p21(ras); Structure-Activity Relationship; Tumor Cells, Cultured; Umbelliferones; Urinary Bladder Neoplasms	1997
Variability of coumarin 7- and 3-hydroxylation in a Jordanian population is suggestive of a functional polymorphism in cytochrome P450 CYP2A6. European journal of clinical pharmacology, 1998, Volume: 54, Issue:5 Topics: Adult; Aryl Hydrocarbon Hydroxylases; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Female; Gas Chromatography-Mass Spectrometry; Genetic Variation; Humans; Hydroxylation; Jordan; Male; Mixed Function Oxygenases; Phenylacetates; Polymorphism, Genetic; Umbelliferones	1998
Determination of 7-hydroxycoumarin and its glucuronide and sulphate conjugates in liver slice incubates by capillary zone electrophoresis. Journal of pharmaceutical and biomedical analysis, 1998, Volume: 17, Issue:8 Topics: Animals; Antineoplastic Agents; Coumarins; Electrophoresis, Capillary; Liver; Mice; Mice, Inbred BALB C; Umbelliferones	1998
Determination of coumarin metabolism in Turkish population. Human & experimental toxicology, 2001, Volume: 20, Issue:4 Topics: Adult; Aged; Amino Acid Substitution; Aryl Hydrocarbon Hydroxylases; Cotinine; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Female; Gene Frequency; Genotype; Humans; Isoenzymes; Male; Middle Aged; Mixed Function Oxygenases; Nicotine; Phenotype; Point Mutation; Polymorphism, Genetic; Smoking; Turkey; Umbelliferones	2001
Random mutagenesis of human cytochrome p450 2A6 and screening with indole oxidation products. Archives of biochemistry and biophysics, 2001, Nov-01, Volume: 395, Issue:1 Topics: Aryl Hydrocarbon Hydroxylases; Cell Membrane; Chromatography, High Pressure Liquid; Coloring Agents; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Escherichia coli; Humans; Indigo Carmine; Indoles; Kinetics; Mixed Function Oxygenases; Mutagenesis; Oxidation-Reduction; Spectrophotometry; Umbelliferones	2001
Decrease of cyclin D1 in the human lung adenocarcinoma cell line A-427 by 7-hydroxycoumarin. Lung cancer (Amsterdam, Netherlands), 2001, Volume: 34, Issue:2 Topics: Adenocarcinoma; Antineoplastic Agents; Biotransformation; Cell Cycle; Cell Division; Coumarins; Cyclin D1; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Umbelliferones	2001
A rapid fluorescence-based assay for detecting soluble methane monooxygenase. Applied microbiology and biotechnology, 2002, Volume: 58, Issue:2 Topics: Coumarins; Fluorescence; Magnetic Resonance Spectroscopy; Methylosinus trichosporium; Oxidation-Reduction; Oxygenases; Solubility; Spectrometry, Fluorescence; Substrate Specificity; Time Factors; Umbelliferones	2002
Phenotypic polymorphism of CYP2A6 activity in a Chinese population. European journal of clinical pharmacology, 2002, Volume: 58, Issue:5 Topics: Adolescent; Adult; Aryl Hydrocarbon Hydroxylases; China; Chromatography, High Pressure Liquid; Coumarins; Cytochrome P-450 CYP2A6; Female; Humans; Male; Mixed Function Oxygenases; Phenotype; Polymorphism, Genetic; Umbelliferones	2002
Comparative metabolism and kinetics of coumarin in mice and rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2003, Volume: 41, Issue:2 Topics: Administration, Oral; Animals; Antineoplastic Agents; Autoradiography; Carcinogens; Coumarins; Diet; Dose-Response Relationship, Drug; Half-Life; Mice; Mice, Inbred Strains; Phenylacetates; Rats; Rats, Inbred F344; Species Specificity; Umbelliferones	2003
Studies in detoxication. 67. The biosynthesis of the glucuronides of umbelliferone and 4-methylumbelliferone and their use in fluorimetric determination of beta-glucuronidase. The Biochemical journal, 1955, Volume: 61, Issue:4 Topics: Coumarins; Fluorometry; Glucuronidase; Glucuronides; Glycoside Hydrolases; Hymecromone; Umbelliferones	1955
[Determination of umbelliferone in mouse-ear hawkweed]. Comptes rendus hebdomadaires des seances de l'Academie des sciences, 1959, Mar-23, Volume: 248, Issue:12 Topics: Animals; Coumarins; Mice; Plants; Umbelliferones	1959
Effects of chronic exposure to low-level cadmium on renal tubular function and CYP2A6-mediated coumarin metabolism in healthy human subjects. Toxicology letters, 2004, Mar-21, Volume: 148, Issue:3 Topics: Adult; Anticoagulants; Aryl Hydrocarbon Hydroxylases; Cadmium; Cadmium Poisoning; Coumarins; Cytochrome P-450 CYP2A6; Dose-Response Relationship, Drug; Female; Humans; Kidney Tubules; Male; Mass Spectrometry; Middle Aged; Mixed Function Oxygenases; Umbelliferones	2004
Apoptosis and cell cycle disturbances induced by coumarin and 7-hydroxycoumarin on human lung carcinoma cell lines. Lung cancer (Amsterdam, Netherlands), 2004, Volume: 43, Issue:3 Topics: Adenocarcinoma; Annexin A5; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cell Cycle; Coumarins; Humans; Lung Neoplasms; Phytohemagglutinins; Tumor Cells, Cultured; Umbelliferones	2004
Identification of Val117 and Arg372 as critical amino acid residues for the activity difference between human CYP2A6 and CYP2A13 in coumarin 7-hydroxylation. Archives of biochemistry and biophysics, 2004, Jul-15, Volume: 427, Issue:2 Topics: Amino Acid Sequence; Amino Acid Substitution; Arginine; Aryl Hydrocarbon Hydroxylases; Binding Sites; Computer Simulation; Coumarins; Cytochrome P-450 CYP2A6; Enzyme Activation; Hydroxylation; Mixed Function Oxygenases; Models, Chemical; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; Sequence Homology, Amino Acid; Structure-Activity Relationship; Umbelliferones; Valine	2004
Generation and characterization of a transgenic mouse model with hepatic expression of human CYP2A6. Biochemical and biophysical research communications, 2005, Dec-09, Volume: 338, Issue:1 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Coumarins; Cytochrome P-450 CYP2A6; Female; Humans; Kinetics; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mixed Function Oxygenases; Models, Animal; Umbelliferones	2005
Enhanced resistance to Salmonella enterica serovar Typhimurium infection in mice after coumarin treatment. Microbes and infection, 2007, Volume: 9, Issue:1 Topics: Animals; Coumarins; Interferon-gamma; Interleukin-12; Liver; Macrophages; Mice; Mice, Inbred BALB C; Monocytes; Neutrophils; Phagocytosis; Reactive Nitrogen Species; Salmonella typhi; Spleen; Th1 Cells; Tumor Necrosis Factor-alpha; Typhoid Fever; Umbelliferones	2007
Antitumor and immunomodulatory effect of coumarin and 7-hydroxycoumarin against Sarcoma 180 in mice. Journal of experimental therapeutics & oncology, 2007, Volume: 6, Issue:2 Topics: Animals; Antineoplastic Agents; Cell Movement; Coumarins; Immunologic Factors; Interleukin-12; Lipopolysaccharides; Macrophage Activation; Mice; Mice, Inbred DBA; Mice, Inbred ICR; Nitric Oxide; Sarcoma 180; Umbelliferones	2007
Rapid probing of photocatalytic activity on titania-based self-cleaning materials using 7-hydroxycoumarin fluorescent probe. Analytica chimica acta, 2008, Feb-04, Volume: 608, Issue:1 Topics: Catalysis; Chemistry Techniques, Analytical; Coloring Agents; Coumarins; Fluorescent Dyes; Photochemistry; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Surface Properties; Time Factors; Titanium; Umbelliferones	2008
Differences in simulated liver concentrations of toxic coumarin metabolites in rats and different human populations evaluated through physiologically based biokinetic (PBBK) modeling. Toxicology in vitro : an international journal published in association with BIBRA, 2008, Volume: 22, Issue:8 Topics: Acetaldehyde; Animals; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Coumarins; Cytochrome P-450 CYP2A6; Humans; Hydroxylation; Microsomes, Liver; Models, Biological; Rats; Species Specificity; Time Factors; Umbelliferones	2008
Evaluation of alternatives to warfarin as probes for Sudlow site I of human serum albumin: characterization by high-performance affinity chromatography. Journal of chromatography. A, 2009, Apr-17, Volume: 1216, Issue:16 Topics: Binding Sites; Binding, Competitive; Chromatography, High Pressure Liquid; Coumarins; Drug Stability; Humans; Kinetics; Magnetic Resonance Spectroscopy; Molecular Probes; Serum Albumin; Umbelliferones; Warfarin	2009
Determination of hydroxyl rate constants by a high-throughput fluorimetric assay: towards a unified reactivity scale for antioxidants. The Analyst, 2009, Volume: 134, Issue:2 Topics: Antioxidants; Calibration; Coloring Agents; Coumarins; Fluorometry; Hydroxyl Radical; Pulse Radiolysis; Thiocyanates; Umbelliferones	2009
A simple fluorescent probe for the determination of dissolved oxygen based on the catalytic activation of oxygen by iron(II) chelates. Analytica chimica acta, 2009, Apr-27, Volume: 640, Issue:1-2 Topics: Calibration; Catalysis; Chelating Agents; Coumarins; Fluorescence; Fluorescent Dyes; Hydrogen-Ion Concentration; Iron; Oxalates; Oxidation-Reduction; Oxygen; Solubility; Spectrometry, Fluorescence; Umbelliferones	2009
Engineering bacterial cytochrome P450 (P450) BM3 into a prototype with human P450 enzyme activity using indigo formation. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:5 Topics: Amino Acid Substitution; Bacterial Proteins; Biocatalysis; Carbon; Chlorzoxazone; Coumarins; Cytochrome P-450 Enzyme System; Enzyme Stability; Escherichia coli; Heme; Humans; Indigo Carmine; Indoles; Kinetics; Molecular Dynamics Simulation; NADPH-Ferrihemoprotein Reductase; Nitrophenols; Oxazines; Oxidation-Reduction; Phenacetin; Protein Engineering; Recombinant Proteins; Transformation, Genetic; Umbelliferones	2010
Functional characterization of cytochrome P450 2A6 allelic variants CYP2A615, CYP2A616, CYP2A621, and CYP2A622. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:5 Topics: Amino Acid Substitution; Aryl Hydrocarbon Hydroxylases; Base Sequence; Biocatalysis; Cell Membrane; Coumarins; Cytochrome P-450 CYP2A6; Escherichia coli; Humans; Kinetics; Mutagenesis, Site-Directed; Polymorphism, Single Nucleotide; Spectrophotometry; Transformation, Genetic; Umbelliferones	2010
Antitermite activities of coumarin derivatives and scopoletin from Protium javanicum Burm. f. Journal of chemical ecology, 2010, Volume: 36, Issue:7 Topics: Animals; Burseraceae; Coumarins; Insecticides; Isoptera; Plant Extracts; Quercetin; Scopoletin; Stigmasterol; Structure-Activity Relationship; Umbelliferones	2010
Synthesis and antibacterial activities of novel 4-hydroxy-7-hydroxy- and 3-carboxycoumarin derivatives. Molecules (Basel, Switzerland), 2012, Sep-10, Volume: 17, Issue:9 Topics: 4-Hydroxycoumarins; Anti-Bacterial Agents; Bacillus subtilis; Bacteria; Coumarins; Escherichia coli; Microbial Sensitivity Tests; Pseudomonas aeruginosa; Staphylococcus aureus; Structure-Activity Relationship; Umbelliferones	2012
A versatile long-wavelength-absorbing scaffold for Eu-based responsive probes. Chemistry (Weinheim an der Bergstrasse, Germany), 2013, Feb-25, Volume: 19, Issue:9 Topics: Absorption; Chelating Agents; Coumarins; Europium; Lanthanoid Series Elements; Luminescence; Luminescent Measurements; Molecular Structure; Spectrophotometry, Ultraviolet; Umbelliferones	2013
Photo responsive monoolein cubic phase containing coumarin-Tween 20 conjugates. Drug development and industrial pharmacy, 2013, Volume: 39, Issue:9 Topics: Anticoagulants; Coumarins; Dimerization; Drug Delivery Systems; Drug Stability; Fluoresceins; Fluorescent Dyes; Glycerides; Hot Temperature; Hymecromone; Kinetics; Magnetic Resonance Spectroscopy; Pharmaceutical Vehicles; Phase Transition; Photochemical Processes; Polysorbates; Solubility; Surface-Active Agents; Ultraviolet Rays; Umbelliferones	2013
Ultrafast branching in the excited state of coumarin and umbelliferone. Physical chemistry chemical physics : PCCP, 2013, Nov-07, Volume: 15, Issue:41 Topics: Coumarins; Electrons; Models, Molecular; Quantum Theory; Solvents; Spectrophotometry, Ultraviolet; Umbelliferones	2013
A kinetic study of the main guaco metabolites using syrup formulation and the identification of an alternative route of coumarin metabolism in humans. PloS one, 2015, Volume: 10, Issue:3 Topics: Administration, Oral; Adult; Coumarins; Drug Combinations; Drug Evaluation, Preclinical; Female; Humans; Male; Mikania; Plant Extracts; Respiratory System Agents; Umbelliferones; Young Adult	2015
Investigation of (E)-3-[4-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators. Journal of medicinal chemistry, 2015, Apr-23, Volume: 58, Issue:8 Topics: Administration, Oral; Animals; Cell Line, Tumor; Coumarins; Down-Regulation; Estrogen Receptor alpha; Humans; Molecular Docking Simulation; Rats; Umbelliferones	2015
Photoprotective effect of coumarin and 3-hydroxycoumarin in sea urchin gametes and embryonic cells. Journal of photochemistry and photobiology. B, Biology, 2015, Volume: 146 Topics: Animals; Coumarins; Dose-Response Relationship, Drug; Embryo, Nonmammalian; Female; Male; Ovum; Protective Agents; Radiation-Protective Agents; Sea Urchins; Spermatozoa; Ultraviolet Rays; Umbelliferones; Zygote	2015
[Chemical constituents from stems of Clausena excavata]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2014, Volume: 37, Issue:11 Topics: Carbazoles; Clausena; Coumarins; Glucosides; Phytochemicals; Plant Stems; Umbelliferones	2014
Coumarin fluorometry to quantitatively detectable OH radicals in ultrasound aqueous medium. Ultrasonics sonochemistry, 2016, Volume: 30 Topics: Coumarins; Fluorescent Dyes; Hydrogen-Ion Concentration; Hydroxyl Radical; Spectrometry, Fluorescence; Ultrasonic Waves; Umbelliferones	2016
Functional Characterization of 34 CYP2A6 Allelic Variants by Assessment of Nicotine C-Oxidation and Coumarin 7-Hydroxylation Activities. Drug metabolism and disposition: the biological fate of chemicals, 2017, Volume: 45, Issue:3 Topics: Alleles; Cotinine; Coumarins; Cytochrome P-450 CYP2A6; HEK293 Cells; Humans; Hydroxylation; Kinetics; Microsomes; Models, Molecular; Nicotine; Oxidation-Reduction; Polymorphism, Genetic; Substrate Specificity; Transfection; Umbelliferones	2017
Metabolic profiles of coumarin in human plasma extrapolated from a rat data set with a simplified physiologically based pharmacokinetic model. The Journal of toxicological sciences, 2020, Volume: 45, Issue:11 Topics: Animals; Computer Simulation; Coumarins; Datasets as Topic; Humans; In Vitro Techniques; Liver; Male; Models, Biological; Phenylacetates; Rats, Sprague-Dawley; Risk Assessment; Umbelliferones	2020
Antiglioma Potential of Coumarins Combined with Sorafenib. Molecules (Basel, Switzerland), 2020, Nov-08, Volume: 25, Issue:21 Topics: 4-Hydroxycoumarins; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Beclin-1; Caspase 3; Cell Line, Tumor; Cell Proliferation; Coumarins; Esculin; Gene Expression Regulation; Glioblastoma; Humans; Magnoliopsida; Necrosis; Phosphatidylinositol 3-Kinases; Plant Extracts; Proto-Oncogene Proteins c-bcl-2; raf Kinases; RNA, Small Interfering; Sorafenib; Umbelliferones	2020
8-Geranylumbelliferone isolated from Paramignya trimera triggers RIPK1/RIPK3-dependent programmed cell death upon TNFR1 ligation. Biochemical pharmacology, 2021, Volume: 192 Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Coumarins; HEK293 Cells; HeLa Cells; HT29 Cells; Humans; MCF-7 Cells; Mice; Mice, Knockout; Plant Extracts; RAW 264.7 Cells; Receptor-Interacting Protein Serine-Threonine Kinases; Receptors, Tumor Necrosis Factor, Type I; Umbelliferones	2021