Compounds > coumarin 3,4-epoxide
Page last updated: 2024-09-03

coumarin 3,4-epoxide and warfarin

coumarin 3,4-epoxide has been researched along with warfarin in 6 studies

Compound Research Comparison

Studies
(coumarin 3,4-epoxide)		Trials
(coumarin 3,4-epoxide)		Recent Studies (post-2010)
(coumarin 3,4-epoxide)		Studies
(warfarin)		Trials
(warfarin)		Recent Studies (post-2010) (warfarin)
70036,5732,14314,728

Protein Interaction Comparison

ProteinTaxonomycoumarin 3,4-epoxide (IC50)warfarin (IC50)
Vitamin K epoxide reductase complex subunit 1 Homo sapiens (human)0.0088

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (16.67)18.2507
2000's5 (83.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Born, SL; Eddy, CL; Lehman-McKeeman, LD; Rodriguez, PA1
Born, SL; Hu, JK; Lehman-McKeeman, LD1
Born, SL; Caudill, D; Lehman-McKeeman, LD; Smith, BJ1
Born, SL; Caudill, D; Fliter, KL; Purdon, MP1
Daston, GP; Hicks, SM; Lehman-McKeeman, LD; Vassallo, JD1
Born, SL; Daston, GP; Hicks, SM; Vassallo, JD1

Other Studies

6 other study(ies) available for coumarin 3,4-epoxide and warfarin

ArticleYear
Synthesis and reactivity of coumarin 3,4-epoxide.
    Drug metabolism and disposition: the biological fate of chemicals, 1997, Volume: 25, Issue:11

    Topics: Chromatography, Gas; Coumarins; Gas Chromatography-Mass Spectrometry; Indicators and Reagents; Magnetic Resonance Spectroscopy; Spectrophotometry, Infrared

1997
o-hydroxyphenylacetaldehyde is a hepatotoxic metabolite of coumarin.
    Drug metabolism and disposition: the biological fate of chemicals, 2000, Volume: 28, Issue:2

    Topics: Acetaldehyde; Animals; Anticoagulants; Cell Survival; Cells, Cultured; CHO Cells; Coumarins; Cricetinae; Gas Chromatography-Mass Spectrometry; Liver; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Sprague-Dawley

2000
In vitro kinetics of coumarin 3,4-epoxidation: application to species differences in toxicity and carcinogenicity.
    Toxicological sciences : an official journal of the Society of Toxicology, 2000, Volume: 58, Issue:1

    Topics: Acetaldehyde; Adult; Animals; Anticoagulants; Antineoplastic Agents; Child, Preschool; Chromatography, Gas; Coumarins; Female; Humans; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Microsomes, Liver; Middle Aged; Rats; Rats, Inbred F344; Species Specificity

2000
Identification of the cytochromes P450 that catalyze coumarin 3,4-epoxidation and 3-hydroxylation.
    Drug metabolism and disposition: the biological fate of chemicals, 2002, Volume: 30, Issue:5

    Topics: Animals; Cosmetics; Coumarins; Cytochrome P-450 Enzyme System; Female; Humans; Hydroxylation; In Vitro Techniques; Lung; Male; Mice; Microsomes; Microsomes, Liver; Rats; Rats, Inbred F344

2002
Metabolic detoxification determines species differences in coumarin-induced hepatotoxicity.
    Toxicological sciences : an official journal of the Society of Toxicology, 2004, Volume: 80, Issue:2

    Topics: Acetaldehyde; Aldehyde Dehydrogenase; Aldehyde Oxidase; Animals; Anticoagulants; Chemical and Drug Induced Liver Injury; Coumarins; Cytosol; Female; Glutathione; Humans; Inactivation, Metabolic; Indicators and Reagents; Male; Mice; Microsomes, Liver; Oxidation-Reduction; Phenylacetates; Rats; Rats, Inbred F344; Species Specificity

2004
Roles for epoxidation and detoxification of coumarin in determining species differences in clara cell toxicity.
    Toxicological sciences : an official journal of the Society of Toxicology, 2004, Volume: 82, Issue:1

    Topics: Animals; Anticoagulants; Coumarins; Epithelial Cells; Female; Inactivation, Metabolic; Male; Mice; Mice, Inbred Strains; Rats; Rats, Inbred F344; Respiratory Mucosa; Species Specificity

2004