Page last updated: 2024-09-05

cotinine n-glucuronide and nicotine

cotinine n-glucuronide has been researched along with nicotine in 11 studies

Compound Research Comparison

Studies
(cotinine n-glucuronide)
Trials
(cotinine n-glucuronide)
Recent Studies (post-2010)
(cotinine n-glucuronide)
Studies
(nicotine)
Trials
(nicotine)
Recent Studies (post-2010) (nicotine)
152328,5192,2809,302

Protein Interaction Comparison

ProteinTaxonomycotinine n-glucuronide (IC50)nicotine (IC50)
Neuronal acetylcholine receptor subunit alpha-4Mus musculus (house mouse)0.0055
Acetylcholine receptor subunit alphaTetronarce californica (Pacific electric ray)0.0025
Acetylcholine receptor subunit betaTetronarce californica (Pacific electric ray)0.0025
Acetylcholine receptor subunit gammaTetronarce californica (Pacific electric ray)0.0025
Acetylcholine receptor subunit deltaTetronarce californica (Pacific electric ray)0.0025
Neuronal acetylcholine receptor subunit alpha-3Rattus norvegicus (Norway rat)0.005
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)0.0046
Neuronal acetylcholine receptor subunit alpha-2Rattus norvegicus (Norway rat)0.005
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)0.0046
Neuronal acetylcholine receptor subunit beta-3Rattus norvegicus (Norway rat)0.005
Neuronal acetylcholine receptor subunit beta-4Rattus norvegicus (Norway rat)0.005
Neuronal acetylcholine receptor subunit beta-2Homo sapiens (human)0.3256
Neuronal acetylcholine receptor subunit alpha-5Rattus norvegicus (Norway rat)0.005
Acetylcholine receptor subunit beta-like 2Drosophila melanogaster (fruit fly)4
Neuronal acetylcholine receptor subunit beta-4Homo sapiens (human)0.43
Neuronal acetylcholine receptor subunit alpha-3Homo sapiens (human)0.1866
Neuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)7.6
Neuronal acetylcholine receptor subunit alpha-6Rattus norvegicus (Norway rat)0.005
Neuronal acetylcholine receptor subunit alpha-9Rattus norvegicus (Norway rat)0.0041
Neuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)0.3456
Neuronal acetylcholine receptor subunit alpha-7Mus musculus (house mouse)0.004
Neuronal acetylcholine receptor subunit beta-3Homo sapiens (human)0.0848
Neuronal acetylcholine receptor subunit alpha-7Rattus norvegicus (Norway rat)0.0087
Neuronal acetylcholine receptor subunit alpha-6Homo sapiens (human)0.0848
Neuronal acetylcholine receptor subunit alpha-5Mus musculus (house mouse)0.004
Liver carboxylesterase B-1Rattus norvegicus (Norway rat)0.045
Neuronal acetylcholine receptor subunit beta-3Mus musculus (house mouse)0.004
Neuronal acetylcholine receptor subunit beta-4Mus musculus (house mouse)0.004
Neuronal acetylcholine receptor subunit alpha-3Mus musculus (house mouse)0.004
Neuronal acetylcholine receptor subunit alpha-2Mus musculus (house mouse)0.004
Neuronal acetylcholine receptor subunit beta-2Mus musculus (house mouse)0.004
Neuronal acetylcholine receptor subunit alpha-10Rattus norvegicus (Norway rat)0.005
Neuronal acetylcholine receptor subunit alpha-6Mus musculus (house mouse)0.004

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (27.27)18.2507
2000's4 (36.36)29.6817
2010's4 (36.36)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Andersson, G; Axéll, T; Curvall, M1
Andersson, G; Curvall, M; Vala, EK1
Hagan, RL; Jacob, PM; Ramos, JM1
Ghosheh, O; Hawes, EM1
Bliss, RL; Carmella, SG; Heath, LA; Hecht, SS; Le, KA; McNiel, EA1
Benowitz, NL; Krasnow, RE; Lessov-Schlaggar, CN; Mwenifumbo, JC; Swan, GE; Tyndale, RF; Zhou, Q1
Feng, S; Kapur, S; Mendes, P; Muhammad, R; Newland, K; Roethig, HJ; Sarkar, M1
Benowitz, NL; Dains, KM; Dempsey, D; Jacob, P; Yu, L1
Brocks, DR; Elsherbiny, ME; Gabr, RQ; Pollak, PT; Somayaji, V1
Carmella, SG; Hatsukami, DK; Hecht, SS; Stepanov, I; Vogel, RI1
Cela, R; Quintana, JB; Rico, M; Rodil, R; Rodríguez-Álvarez, T1

Trials

2 trial(s) available for cotinine n-glucuronide and nicotine

ArticleYear
Identification of novel CYP2A6*1B variants: the CYP2A6*1B allele is associated with faster in vivo nicotine metabolism.
    Clinical pharmacology and therapeutics, 2008, Volume: 83, Issue:1

    Topics: 3' Flanking Region; Aryl Hydrocarbon Hydroxylases; Base Sequence; Biotransformation; Cotinine; Cytochrome P-450 CYP2A6; Deuterium; Gene Frequency; Genetic Linkage; Genotype; Glucuronates; Humans; Infusions, Intravenous; Mixed Function Oxygenases; Molecular Sequence Data; Nicotine; Nicotinic Agonists; Phenotype; Polymorphism, Genetic; Sequence Alignment; Substrate Specificity

2008
Respiratory retention of nicotine and urinary excretion of nicotine and its five major metabolites in adult male smokers.
    Toxicology letters, 2007, Sep-10, Volume: 173, Issue:2

    Topics: Adult; Biomarkers; Biotransformation; Breath Tests; Chromatography, Liquid; Cotinine; Glucuronates; Half-Life; Humans; Inhalation; Lung; Male; Models, Biological; Nicotine; Nicotinic Agonists; Smoking; Tandem Mass Spectrometry

2007

Other Studies

9 other study(ies) available for cotinine n-glucuronide and nicotine

ArticleYear
Reduction in nicotine intake and oral mucosal changes among users of Swedish oral moist snuff after switching to a low-nicotine product.
    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 1995, Volume: 24, Issue:6

    Topics: Adult; Cotinine; Cyclic N-Oxides; Glucuronates; Humans; Mouth Diseases; Mouth Mucosa; Nicotine; Plants, Toxic; Saliva; Sweden; Time Factors; Tobacco, Smokeless

1995
The influence of cigarette consumption and smoking machine yields of tar and nicotine on the nicotine uptake and oral mucosal lesions in smokers.
    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 1997, Volume: 26, Issue:3

    Topics: Adult; Cotinine; Cyclic N-Oxides; Environmental Exposure; Glucuronates; Humans; Leukoedema, Oral; Leukoplakia, Oral; Male; Middle Aged; Mouth Diseases; Mouth Mucosa; Nicotiana; Nicotine; Plants, Toxic; Prevalence; Smoking; Tars; Time Factors; Tongue, Hairy

1997
Increasing urinary cotinine concentrations at elevated temperatures: the role of conjugated metabolites.
    Journal of pharmaceutical and biomedical analysis, 1997, Volume: 16, Issue:2

    Topics: Chromatography, Gas; Cotinine; Drug Stability; Humans; Mass Spectrometry; Nicotine; Nicotinic Agonists; Smoking; Temperature; Time Factors

1997
N-glucuronidation of nicotine and cotinine in human: formation of cotinine glucuronide in liver microsomes and lack of catalysis by 10 examined UDP-glucuronosyltransferases.
    Drug metabolism and disposition: the biological fate of chemicals, 2002, Volume: 30, Issue:9

    Topics: Catalysis; Cotinine; Glucuronates; Glucuronides; Glucuronosyltransferase; Humans; In Vitro Techniques; Kinetics; Microsomes, Liver; Nicotine; Recombinant Proteins; Stereoisomerism

2002
Urinary biomarkers to assess exposure of cats to environmental tobacco smoke.
    American journal of veterinary research, 2007, Volume: 68, Issue:4

    Topics: Animals; Biomarkers; Cats; Cotinine; Gas Chromatography-Mass Spectrometry; Glucuronates; Nicotine; Nitrosamines; Pyridines; Tobacco Smoke Pollution

2007
Estimation of nicotine dose after low-level exposure using plasma and urine nicotine metabolites.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2010, Volume: 19, Issue:5

    Topics: Adult; Biomarkers; Cotinine; Dose-Response Relationship, Drug; Female; Glucuronates; Humans; Male; Middle Aged; Nicotine; Smoking; Tobacco Smoke Pollution; Young Adult

2010
A liquid chromatography-mass spectrometry method for nicotine and cotinine; utility in screening tobacco exposure in patients taking amiodarone.
    Biomedical chromatography : BMC, 2011, Volume: 25, Issue:10

    Topics: Amiodarone; Cardiovascular Diseases; Chromatography, Reverse-Phase; Cotinine; Humans; Liquid-Liquid Extraction; Mass Spectrometry; Milrinone; Nicotine; Reproducibility of Results; Tobacco Smoke Pollution

2011
The ratio of a urinary tobacco-specific lung carcinogen metabolite to cotinine is significantly higher in passive than in active smokers.
    Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2011, Volume: 16, Issue:6

    Topics: Adolescent; Adult; Biomarkers; Carcinogens; Child; Child, Preschool; Cotinine; Humans; Infant; Lung; Middle Aged; Nicotiana; Nicotine; Nitrosamines; Pyridines; Randomized Controlled Trials as Topic; Smoking; Tobacco Smoke Pollution

2011
Assessment of local tobacco consumption by liquid chromatography-tandem mass spectrometry sewage analysis of nicotine and its metabolites, cotinine and trans-3'-hydroxycotinine, after enzymatic deconjugation.
    Analytical chemistry, 2014, Oct-21, Volume: 86, Issue:20

    Topics: Chemistry Techniques, Analytical; Chromatography, Liquid; Cotinine; Humans; Nicotine; Population Surveillance; Sewage; Spain; Tandem Mass Spectrometry; Tobacco Use

2014