cosmomycin-d and mycothiol

Antibiotic-producing microorganisms usually require one or more self-resistance determinants to survive antibiotic production. The effectors of these mechanisms are proteins that inactivate the antibiotic, facilitate its transport, or modify the target to render it insensitive to the molecule. Streptomyces bacteria biosynthesize various bioactive natural products and possess resistance systems for most metabolites, which are coregulated with antibiotic biosynthesis genes. Streptomyces olindensis strain DAUFPE 5622 produces the antitumor antibiotic cosmomycin D (COSD), a member of the anthracycline family. In this study, we propose three self-resistance mechanisms, anchored or based in the COSD biosynthetic gene cluster. These include

Topics: Anthracyclines; Anti-Bacterial Agents; Antioxidants; ATP-Binding Cassette Transporters; Cysteine; Glycopeptides; Inositol; Oxidoreductases; Peroxidase; Peroxidases; Streptomyces