corynoxine has been researched along with hirsutine* in 2 studies
2 other study(ies) available for corynoxine and hirsutine
| Article | Year |
|---|---|
Pharmacokinetics of Eleven Kratom Alkaloids Following an Oral Dose of Either Traditional or Commercial Kratom Products in Rats.
Kratom, Topics: Alkaloids; Animals; Indole Alkaloids; Indoles; Male; Mitragyna; Molecular Structure; Oxindoles; Plant Preparations; Rats; Rats, Sprague-Dawley; Secologanin Tryptamine Alkaloids; Spiro Compounds | 2021 |
Macrophyllionium and macrophyllines A and B, oxindole alkaloids from Uncaria macrophylla.
An unusual oxindole alkaloid inner salt, macrophyllionium (1), and a pair of new tetracyclic oxindole alkaloids, macrophyllines A (2) and B (3), together with six known alkaloids, were isolated from the aerial parts of Uncaria macrophylla. Corynantheidine (8) exhibited moderate cytotoxicity against HL-60 and SW480 cells with IC(50) values of 13.96 and 23.28 μM, respectively. Dihydrocorynantheine (9) exhibited significant vasodilating activity against phenylephrine-induced contraction in rat thoracic aorta rings (IC(50) = 6.73 μg/mL). In addition, compounds 2, 6, and 9 showed weak inhibitory action on KCl-induced contraction. Topics: Alkaloids; Animals; Aorta, Thoracic; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; HL-60 Cells; Humans; Indole Alkaloids; Indoles; Inhibitory Concentration 50; Male; Molecular Structure; Oxindoles; Phenylephrine; Potassium Chloride; Rats; Rats, Sprague-Dawley; Stereoisomerism; Uncaria; Vasodilation | 2011 |