cortisol-succinate--sodium-salt and dexamethasone-21-phosphate

Reports of corticosteroid sensitivity reactions are rare in the medical literature. We report an anaphylactoid reaction to hydrocortisone sodium succinate given intravenously which occurred on two occasions during treatment of a patient for asthma. Intradermal testing with a wide range of steroid preparations gave positive results with hydrocortisone sodium succinate, methylprednisolone sodium succinate, methylprednisolone sodium succinate and methylprednisolone acetate. No reactions occurred to dexamethasone sodium phosphate administered intravenously, prednisolone given orally or beclomethasone dipropionate by inhalation. Results of a radioallergosorbent test (RAST) were negative for hydrocortisone sodium succinate.

Topics: Administration, Inhalation; Adult; Anaphylaxis; Asthma; Beclomethasone; Dexamethasone; Humans; Hydrocortisone; Injections, Intravenous; Intradermal Tests; Male; Recurrence; Skin Tests

To study and compare the efficacy of supratarsal injection of dexamethasone sodium phosphate, triamcinolone acetonide and hydrocortisone sodium succinate in treating refractory vernal keratoconjunctivitis (VKC).. Prospective randomized, double-masked, case control trial, including 90 eyes of 45 patients with refractory VKC. Both eyes of each patient were randomly assigned to receive supratarsal injection of one of three compounds under study: dexamethasone sodium phosphate (2 mg), triamcinolone acetonide (10.5 mg), and hydrocortisone sodium succinate (50 mg).. All the three drugs were equally effective with no statistically significant difference in the time of resolution of cobblestone papillae, lid oedema, conjunctival discharge and chemosis, Tranta's dots and shield ulcers. There was no statistically significant difference in the severity and rate of recurrence of disease following supratarsal injection of all the three drugs. But recurrence of disease to same severity was seen within 6 months of injection in all cases irrespective of compounds used.. Supratarsal injection of corticosteroids is very effective for temporary suppression of severe inflammation associated with VKC.

Topics: Anti-Inflammatory Agents; Conjunctivitis, Allergic; Dexamethasone; Double-Blind Method; Eyelids; Humans; Hydrocortisone; Injections; Recurrence; Triamcinolone Acetonide

Purpose We retrospectively studied the efficacy of intratympanic steroid administration in comparison with hyperbaric oxygen (HBO) therapy for idiopathic sudden sensorineural hearing loss (ISSNHL) with negative prognostic factors. Method We enrolled 301 patients (302 ears) with ISSNHL (average hearing level at 250-4000 Hz ≥ 40 dB; time from onset to treatment ≤ 30 days). From August 2002 to March 2009, 174 patients (174 ears) received systemic steroid plus HBO therapy (HBO group), and from June 2015 to January 2018, 127 patients (128 ears) received systemic plus intratympanic steroid (IT group). Hearing outcomes were evaluated by 6 indices: cure rate, marked-recovery rate (percent of patients with hearing gain ≥ 30 dB), recovery rate (percent of patients with hearing gain ≥ 10 dB), hearing gain, hearing level after treatment, and percent hearing improvement compared to the unaffected contralateral ear. Results The recovery rate was significantly higher in the IT group than in the HBO group (80.5% vs. 68.4%, p = .019). The IT group showed a higher recovery rate than the HBO group in patients aged ≥ 60 years ( p = .010), patients with early (≤ 7 days from onset) treatment ( p = .005), patients with initial hearing levels ≥ 90 dB ( p = .037), and patients with vertigo/dizziness ( p = .040). The IT group also showed higher hearing gain and percent hearing improvement than the HBO group in patients with vertigo/dizziness ( p = .046 and p = .026, respectively). Conclusions Systemic plus intratympanic steroid is more effective for ISSNHL than systemic steroid plus HBO, particularly in patients with negative prognostic factors, such as old age, profound hearing loss, and/or presence of vertigo/dizziness.

Topics: Anti-Inflammatory Agents; Audiometry; Dexamethasone; Female; Glucocorticoids; Hearing Loss, Sensorineural; Hearing Loss, Sudden; Humans; Hydrocortisone; Hyperbaric Oxygenation; Injection, Intratympanic; Male; Middle Aged; Middle Ear Ventilation; Prednisolone; Prognosis; Recovery of Function; Retrospective Studies; Time-to-Treatment; Treatment Outcome; Vertigo

The detrimental role of corticosteroids on wound healing is well recognized. This study examined the effect of equipotent anti-inflammatory doses of dexamethasone sodium phosphate, methylprednisolone sodium succinate, or hydrocortisone sodium succinate on wound healing in mice. Mice were injected daily for 12 days; the mice were wounded on day 3 of steroid injection, with wound analysis done on day 10 after wounding. Dexamethasone and hydrocortisone significantly impaired wound healing, as assessed by wound disruption strength when compared with controls or methylprednisolone. Dexamethasone and hydrocortisone both displayed dose-dependent relationships for impairment of healing, while over comparative doses, methylprednisolone failed to affect healing significantly. Regression analysis revealed nearly identical curves for hydrocortisone and dexamethasone that differed significantly from that of methylprednisolone. Our observations suggested that these preparations possessed a differential effect on the healing wound that should be considered to minimize postsurgical or traumatic wound-healing problems.

Topics: Animals; Anti-Inflammatory Agents; Dexamethasone; Dose-Response Relationship, Drug; Hydrocortisone; Male; Methylprednisolone Hemisuccinate; Mice; Wound Healing

1. Pharmacologic doses of hydrocortisone sodium succinate (100 mg/kg) has a rapid protective action against arachidonate-induced mortality in mice when administered intravenously 5 to 60 min before intravenous infusion of arachidonate. 2. Intravenous dexamethasone sodium phosphate (4 mg/kg) has a similar protective effect. 3. The time course of the development of the protective effect of intravenous glucocorticoids suggests that DNA transcription and protein synthesis are not involved in the mechanism of this action. 4. Longer pretreatment with glucocorticoids are required to reduce mortality when subcutaneous or intraperitoneal routes of administration of the steroids used.

Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cortisone; Dexamethasone; Hydrocortisone; Kinetics; Male; Mice; Platelet Aggregation; Time Factors

Sensitivity of CA3 field neurones to hydrocortisone hemisuccinate, sodium dexamethasone-21-phosphate and angiotensin II was studied in experiments on surviving sections of the mouse hippocampus. High sensitivity of the neurones of surviving sections of the hippocampus to the steroid hormones (hydrocortisone and dexamethasone) and virtually complete absence of responses to angiotensin II were demonstrated.

Topics: Angiotensin II; Animals; Dexamethasone; Hippocampus; Hydrocortisone; Mice; Mice, Inbred CBA; Models, Neurological; Neurons