coronardine and voacamine

coronardine has been researched along with voacamine* in 1 studies

Other Studies

1 other study(ies) available for coronardine and voacamine

Article	Year
Indole alkaloids from Peschiera laeta that enhance vinblastine-mediated cytotoxicity with multidrug-resistant cells. Journal of natural products, 1994, Volume: 57, Issue:11 Coronaridine [1], conoduramine [2], and voacamine [3], three indole alkaloids isolated from Peschiera laeta, have been found to enhance the cytotoxic response mediated by vinblastine [4] with multidrug-resistant KB cells. Inhibition of vinblastine binding with membrane vesicles isolated from this cell line was also assessed, and the bisindole alkaloids conoduramine [2] and voacamine [3] were found to be more potent inhibitory agents than the monomeric alkaloid, coronaridine [1]. Thus, these compounds appear to function by binding with P-glycoprotein. Topics: Alkaloids; Antineoplastic Agents; Cell Survival; Drug Resistance, Multiple; Drug Synergism; Humans; Ibogaine; KB Cells; Trees; Vinblastine	1994

Article

Year

Indole alkaloids from Peschiera laeta that enhance vinblastine-mediated cytotoxicity with multidrug-resistant cells.

Journal of natural products, 1994, Volume: 57, Issue:11

Coronaridine [1], conoduramine [2], and voacamine [3], three indole alkaloids isolated from Peschiera laeta, have been found to enhance the cytotoxic response mediated by vinblastine [4] with multidrug-resistant KB cells. Inhibition of vinblastine binding with membrane vesicles isolated from this cell line was also assessed, and the bisindole alkaloids conoduramine [2] and voacamine [3] were found to be more potent inhibitory agents than the monomeric alkaloid, coronaridine [1]. Thus, these compounds appear to function by binding with P-glycoprotein.

Topics: Alkaloids; Antineoplastic Agents; Cell Survival; Drug Resistance, Multiple; Drug Synergism; Humans; Ibogaine; KB Cells; Trees; Vinblastine

1994