coronardine and catharanthine

coronardine has been researched along with catharanthine* in 2 studies

Other Studies

2 other study(ies) available for coronardine and catharanthine

Article	Year
Synthesis of (-)-pseudotabersonine, (-)-pseudovincadifformine, and (+)-coronaridine enabled by photoredox catalysis in flow. Journal of the American Chemical Society, 2014, Jul-23, Volume: 136, Issue:29 Natural product modification with photoredox catalysis allows for mild, chemoselective access to a wide array of related structures in complex areas of chemical space, providing the possibility for novel structural motifs as well as useful quantities of less abundant congeners. While amine additives have been used extensively as stoichiometric electron donors for photocatalysis, the controlled modification of amine substrates through single-electron oxidation is ideal for the synthesis and modification of alkaloids. Here, we report the conversion of the amine (+)-catharanthine into the natural products (-)-pseudotabersonine, (-)-pseudovincadifformine, and (+)-coronaridine utilizing visible light photoredox catalysis. Topics: Catalysis; Ibogaine; Indole Alkaloids; Light; Molecular Conformation; Oxidation-Reduction; Photochemical Processes; Stereoisomerism; Vinca Alkaloids	2014
Determination of antiplasmodial activity and binding affinity of selected natural products towards PfTrxR and PfGR. Natural product communications, 2013, Volume: 8, Issue:8 In our study, the binding affinities of selected natural products towards PfTrxR, PfGR, human TrxR and human GR were determined using a mass spectrometry based ligand binding assay. The in vitro antimalarial activity and cytotoxicity of these ligands were also determined. Catharanthine, 11-(OH)-coronaridine, hernagine, vobasine and hispolone displayed antiplasmodial activity against PfK1 (IC50 = 0.996-3.63 microg/mL). Topics: Animals; Antiprotozoal Agents; Biological Products; Glutathione Reductase; Humans; Ibogaine; Indole Alkaloids; Inhibitory Concentration 50; Plasmodium falciparum; Thioredoxin-Disulfide Reductase; Vinca Alkaloids	2013

Article

Year

Synthesis of (-)-pseudotabersonine, (-)-pseudovincadifformine, and (+)-coronaridine enabled by photoredox catalysis in flow.

Journal of the American Chemical Society, 2014, Jul-23, Volume: 136, Issue:29

Natural product modification with photoredox catalysis allows for mild, chemoselective access to a wide array of related structures in complex areas of chemical space, providing the possibility for novel structural motifs as well as useful quantities of less abundant congeners. While amine additives have been used extensively as stoichiometric electron donors for photocatalysis, the controlled modification of amine substrates through single-electron oxidation is ideal for the synthesis and modification of alkaloids. Here, we report the conversion of the amine (+)-catharanthine into the natural products (-)-pseudotabersonine, (-)-pseudovincadifformine, and (+)-coronaridine utilizing visible light photoredox catalysis.

Topics: Catalysis; Ibogaine; Indole Alkaloids; Light; Molecular Conformation; Oxidation-Reduction; Photochemical Processes; Stereoisomerism; Vinca Alkaloids

2014

Determination of antiplasmodial activity and binding affinity of selected natural products towards PfTrxR and PfGR.

Natural product communications, 2013, Volume: 8, Issue:8

In our study, the binding affinities of selected natural products towards PfTrxR, PfGR, human TrxR and human GR were determined using a mass spectrometry based ligand binding assay. The in vitro antimalarial activity and cytotoxicity of these ligands were also determined. Catharanthine, 11-(OH)-coronaridine, hernagine, vobasine and hispolone displayed antiplasmodial activity against PfK1 (IC50 = 0.996-3.63 microg/mL).

Topics: Animals; Antiprotozoal Agents; Biological Products; Glutathione Reductase; Humans; Ibogaine; Indole Alkaloids; Inhibitory Concentration 50; Plasmodium falciparum; Thioredoxin-Disulfide Reductase; Vinca Alkaloids

2013