cord-factors and picric-acid

cord-factors has been researched along with picric-acid* in 1 studies

Other Studies

1 other study(ies) available for cord-factors and picric-acid

Article	Year
Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling. Science (New York, N.Y.), 2006, Dec-22, Volume: 314, Issue:5807 Innate immune signals mediated by Toll-like receptors (TLRs) have been thought to contribute considerably to the antibody-enhancing effects of vaccine adjuvants. However, we report here that mice deficient in the critical signaling components for TLR mount robust antibody responses to T cell-dependent antigen given in four typical adjuvants: alum, Freund's complete adjuvant, Freund's incomplete adjuvant, and monophosphoryl-lipid A/trehalose dicorynomycolate adjuvant. We conclude that TLR signaling does not account for the action of classical adjuvants and does not fully explain the action of a strong adjuvant containing a TLR ligand. This may have important implications in the use and development of vaccine adjuvants. Topics: Adaptor Proteins, Vesicular Transport; Adjuvants, Immunologic; Animals; Antibody Formation; Antigens, T-Independent; B-Lymphocytes; Cell Wall Skeleton; Cord Factors; Freund's Adjuvant; Haptens; Hemocyanins; Immunity, Innate; Immunization; Immunization, Secondary; Immunoglobulins; Ligands; Lipid A; Lipopolysaccharides; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Myeloid Differentiation Factor 88; Picrates; Signal Transduction; T-Lymphocytes; Toll-Like Receptors; Vaccines	2006

Article

Year

Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling.

Science (New York, N.Y.), 2006, Dec-22, Volume: 314, Issue:5807

Innate immune signals mediated by Toll-like receptors (TLRs) have been thought to contribute considerably to the antibody-enhancing effects of vaccine adjuvants. However, we report here that mice deficient in the critical signaling components for TLR mount robust antibody responses to T cell-dependent antigen given in four typical adjuvants: alum, Freund's complete adjuvant, Freund's incomplete adjuvant, and monophosphoryl-lipid A/trehalose dicorynomycolate adjuvant. We conclude that TLR signaling does not account for the action of classical adjuvants and does not fully explain the action of a strong adjuvant containing a TLR ligand. This may have important implications in the use and development of vaccine adjuvants.

Topics: Adaptor Proteins, Vesicular Transport; Adjuvants, Immunologic; Animals; Antibody Formation; Antigens, T-Independent; B-Lymphocytes; Cell Wall Skeleton; Cord Factors; Freund's Adjuvant; Haptens; Hemocyanins; Immunity, Innate; Immunization; Immunization, Secondary; Immunoglobulins; Ligands; Lipid A; Lipopolysaccharides; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Myeloid Differentiation Factor 88; Picrates; Signal Transduction; T-Lymphocytes; Toll-Like Receptors; Vaccines

2006