coptisine has been researched along with berberine in 133 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (1.50) | 18.7374 |
| 1990's | 8 (6.02) | 18.2507 |
| 2000's | 25 (18.80) | 29.6817 |
| 2010's | 82 (61.65) | 24.3611 |
| 2020's | 16 (12.03) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, JH; Kim, YH; Lee, WS; Ryu, YB | 1 |
| Furuta, K; Hattori, T; Ito, M; Nagamatsu, T; Nagao, T; Suzuki, Y | 1 |
| Furuya, T; Hirotani, M; Kobayashi, S; Matsumoto, H; Metori, K; Mineo, S; Satoh, T; Tanaka, T | 1 |
| Fang, XP; Li, D; Shuai, H; Wang, TZ; Xie, CK; Zhang, H | 1 |
| Kakizawa, S; Misaki, T; Ojima, M; Oshima, T; Sagara, K; Yoshizawa, H | 1 |
| Hatanaka, T; Kadota, S; Katayama, K; Koizumi, T; Namba, T; Sekiya, K; Toshinal, A | 1 |
| Boegge, SC; Kesper, S; Nahrstedt, A; Verspohl, EJ | 1 |
| Ghorbani, M; Hiller, KO; Schilcher, H | 1 |
| Ishida, S; Miki, H; Okamura, N; Ono, H; Ono, Y; Tanaka, T; Yagi, A; Yano, A | 1 |
| Ahn, YJ; Chae, SH; Choi, DH; Jeong, IH; Oh, JW | 1 |
| Chen, YR; Her, GR; Wen, KC | 1 |
| Kai, M; Kim, EI; Lee, MK; Shin, JS | 1 |
| Ahn, YJ; Lee, HS; Lee, SG; Park, IK; Park, JD | 1 |
| Hu, JP; Takahashi, N; Yamada, T | 1 |
| Iwasa, K; Lee, DU; Moriyasu, M; Turuo, T; Wiegrebe, W; Yamori, T | 1 |
| Bochoráková, H; Slanina, J; Slaninová, I; Táborská, E | 1 |
| Hirano, H; Osawa, E; Yamaoka, Y; Yokoi, T | 1 |
| Lee, KS; Lee, MK; Lee, SS; Ro, JS | 1 |
| Wei, L; Yang, D; Zhou, H | 1 |
| Inada, A; Muto, N; Nakanishi, T; Ootaki, K; Shigeta, K; Tatemoto, H | 1 |
| Cheng, YY; Peng, MX; Wu, YJ | 1 |
| Sun, SW; Tseng, HM | 1 |
| Li, ZH; Qin, HL; Wang, P; Yang, JR | 1 |
| Chen, SJ; Huang, XP; Ma, KS; Qin, SY; Zhong, GY | 1 |
| Chen, CL; Han, T; Li, HL; Liu, RH; Wang, XL; Wang, XW; Zhang, C; Zhang, WD; Zhu, JB | 1 |
| Tang, YL; Wang, HQ; Zhao, DB | 1 |
| Inoue, M; Mizukami, H; Nagatsu, A; Ogihara, Y; Suzuki, H; Tanabe, H | 1 |
| Seger, C; Stuppner, H; Sturm, S | 1 |
| Liang, X; Ren, L; Xu, Q; Xue, X; Zhang, F | 1 |
| Ma, Y; Shi, R; Tan, B; Wang, T | 1 |
| Ma, L; Yang, XW | 1 |
| Dostál, J; Grycová, L; Hulová, D; Kares, R; Lemière, F; Maier, L; Marek, R; Necas, M; Standara, S | 1 |
| Cheng, XY; Jin, W; Shi, Y; Sun, H; Zheng, SL | 1 |
| Feng, J; Jin, Y; Liang, X; Liu, Y; Xiao, Y; Xue, X; Zhang, J; Zhang, X | 1 |
| Jin, C; Kong, WJ; Li, HB; Li, ZL; Xiao, XH; Zhao, YL | 1 |
| Chen, X; Chu, H; Li, X; Li, Y; Liu, G; Ye, X; Zhou, J; Zhu, Y | 1 |
| Inoue, M; Mizukami, H; Suzuki, H; Tanabe, H | 2 |
| Geng, Z; Luo, W; Qu, X; Zhang, Y; Zheng, H | 1 |
| Hasada, K; Mizukami, H; Nagatsu, A; Nishimura, T; Sugimoto, N; Yamazaki, T; Yoshida, T | 1 |
| Gao, C; Jiang, J; Qiu, F; Tan, Y; Zhang, X | 1 |
| Du, LM; Wu, H; Zhang, LB | 1 |
| Cha, BY; Hasegawa, S; Iwahashi, A; Jeon, WB; Lee, JW; Nagai, K; Woo, JT; Yonezawa, T | 1 |
| Di, X; Liu, Y; Shen, W; Wang, Y; Yan, R | 1 |
| Chen, LQ; Ding, PL; Li, YG; Lu, Y | 1 |
| Du, GH; Fang, LH; Gong, LL; Li, XX; Qin, HL; Sun, JL; Wang, SB | 1 |
| Du, GH; Fang, LH; Gong, LL; Lv, Y; Qin, HL | 1 |
| Cui, XJ; Hai, L; He, Y; Lei, F; Wu, JB; Wu, Y; Zhang, J | 1 |
| Chen, HY; Chen, SQ; Jin, Z | 1 |
| Chen, Z; Liu, L | 1 |
| Feng, W; Kong, J; Wang, Z; Zhang, Q; Zhu, J | 1 |
| Fan, G; Lai, XR; Luo, WZ; Tang, C; Yue, QH; Zhang, MY; Zhang, Y; Zhou, XD | 1 |
| He, K; Li, X; Liu, X; Wang, D; Yang, Y; Ye, X; Yi, J | 1 |
| Huang, QW; Li, XF; Su, J; Wang, J; Zhang, YL | 1 |
| Fan, X; Hu, M; Su, D; Xu, Y; Yu, J | 1 |
| Kang, J; Zhang, Y | 1 |
| Du, GH; Fang, LH; Gong, LL; Guo, J; Li, L; Qin, HL; Wang, SB; Wu, YJ; Xu, XN; Yan, Y; Yuan, TY | 1 |
| Deng, AJ; Li, ZH; Qin, HL; Wang, WJ; Wu, LQ; Yu, JQ; Zhang, ZH | 1 |
| Cheng, P; Kang, W; Liu, W; Liu, X; Wang, B; Zeng, J; Zhou, J | 1 |
| Di, DL; Liu, JX; Ma, YX; Zhong, M | 1 |
| Bao, M; Cao, Z; Fu, S; Liu, W; Pan, Y; Yu, D; Zhang, G; Zhou, Q | 1 |
| Li, BC; Li, JX; Wang, JY; Wang, RL; Xiao, XH; Yan, D; Zhang, LL | 1 |
| Han, L; Qu, J; Qu, Q; Wu, LX; Zhan, M; Zhang, W; Zhang, YW; Zhou, HH | 1 |
| Liu, JX; Ma, ZT; Yang, XW; Zhang, Y | 1 |
| Dong, XP; Gao, D; Ma, LN; Sheng, FY; Xiao, XH; Xiong, Y; Yan, D; Zhang, CE; Zhang, LL | 1 |
| Deng, AJ; Li, ZH; Qin, HL; Wang, WJ; Wu, LQ; Yu, JQ; Zhang, HJ; Zhang, ZH | 1 |
| Du, LS; He, XJ; Tao, BB; Yan, JK; Yang, Q; Yang, SS; Yang, YY; Yu, D; Zhu, YW | 1 |
| Cao, SP; Chen, SH; Li, J; Qiu, DM; Xia, XL | 1 |
| Gao, Q; Li, XG; Pang, J; Wang, DZ; Wang, YZ; Zou, ZY | 1 |
| Deng, AJ; Du, GH; Fang, LH; Li, ZH; Qin, HL; Wang, WJ; Wu, LQ; Yu, JQ; Yuan, TY; Zhang, ZH | 1 |
| Bian, B; Han, L; Li, Y; Ren, W; Si, N; Wang, H; Wei, X; Xin, S; Yang, J; Zhao, H; Zuo, R | 1 |
| Du, LM; Feng, JX; Fu, YL; Li, CF; Li, Y; Liu, HL | 1 |
| Chen, B; Fang, X; He, K; Hu, Y; Li, X; Ning, N; Wang, Y; Wu, H; Ye, X; Zou, Z | 1 |
| Cai, F; Hu, P; Li, Y; Wang, Y; Zhang, H; Zhang, M | 1 |
| Hänsel, S; Ibrom, K; Kleinwächter, M; Paulsen, J; Selmar, D; Yahyazadeh, M | 1 |
| Kim, JH; Kim, OS; Seo, CS; Shin, HK | 1 |
| He, K; Hu, YR; Li, XG; Ma, H; Wang, YZ; Wu, H; Xia, S; Xue, DF; Ye, XL; Zou, ZY | 1 |
| Bai, M; Jiang, H; Li, L; Song, F; Sun, S; Weng, Y; Zeng, S; Zhou, H; Zhou, S | 1 |
| Chen, N; Ma, S; Miao, P; Miao, Q; Su, J; Zhang, Y; Zhao, Y | 1 |
| Dou, L; Li, X; Song, Y; Wang, X; Xue, H; Yue, Y | 1 |
| Chen, B; Han, B; Kou, SM; Li, XG; Xue, DF; Ye, XL | 1 |
| Deng, AJ; Li, ZH; Liu, Y; Qin, HL; Wang, B; Wang, WJ; Wu, LQ; Zhang, HJ; Zhang, ZH | 1 |
| Seo, CS; Shin, HK | 1 |
| Bianucci, AM; Borghini, A; Pietra, D | 1 |
| Deng, AJ; Li, ZH; Qin, HL; Wang, WJ; Wu, LQ; Xie, M; Zhang, HJ; Zhang, ZH | 1 |
| Hu, B; Meng, X; Wang, F; Wang, P; Wu, J; Yang, L; Zhang, H | 1 |
| Deng, AJ; Li, J; Li, ZH; Qin, HL; Song, HR; Wang, WJ; Wu, LQ; Zhang, HJ; Zhang, ZH | 1 |
| Hu, L; Liao, W; Rui, F; Yin, D; Zhou, K | 1 |
| Feng, M; He, K; Hu, YR; Li, XG; Ma, H; Wang, Y; Xiao, YB; Ye, XL; Zou, ZY | 1 |
| Chen, Y; Du, G; Fang, L; He, Y; Qin, H; Song, J; Wang, X; Yan, Y; Zhang, H; Zhang, Z | 1 |
| Chen, C; Lian, W; Liu, S; Shi, L; Su, R; Wan, D; Wang, Y; Xu, N; Yang, H; Yao, W | 1 |
| Han, B; He, K; Huang, T; Li, L; Li, X; Ma, H; Tian, C; Wang, M; Wang, Y; Xiao, Y; Ye, X; Yi, L | 1 |
| Chen, F; Du, D; Gu, F; Li, F; Liang, J; Liu, X | 1 |
| Begum, S; Rao, PC; Sahai, M; Sriram, DS | 1 |
| Chatterjee, S; Suresh Kumar, G | 1 |
| Chen, H; Fan, S; Gu, M; Huang, C; Jiang, X; Ke, Z; Wang, D; Wang, Q; Wang, Y; Zhang, L; Zhao, Y | 1 |
| Chen, HB; Li, CL; Liang, JL; Lin, GS; Luo, CD; Su, ZR; Tan, LH; Wu, JZ; Xie, JH; Yang, XB; Zeng, HF; Zhang, ZB | 1 |
| Jeong, SJ; Kim, BY; Kim, Y; Kim, YJ; Lee, J; Lim, HS | 1 |
| Cong, H; Deng, S; Huo, X; Sun, C; Wang, C; Wang, Y; Wu, B; Xiang, T; Zhang, B; Zhang, H; Zhang, L; Zhao, X; Zheng, L | 1 |
| Bazzicalupi, C; Da Ros, S; Ferraroni, M; Gratteri, P; Papi, F; Rigo, R; Sissi, C | 1 |
| Chen, H; Lai, X; Li, C; Lin, G; Luo, C; Su, Z; Tan, L; Wang, Y; Xie, J; Zeng, H | 1 |
| Chai, FN; Li, XG; Li, YF; Ma, WY; Xiang, HM; Xu, HS; Ye, XL; Zhang, J | 1 |
| Jiang, Y; Li, HJ; Li, P; Lu, J; Ni, H; Wu, TJ | 1 |
| Hu, Q; Huang, J; Huang, Y; Lang, L; Liu, Z; Lu, W; Wang, J | 1 |
| Gao, Y; Niu, X; Sun, L; Wang, G; Wang, H; Wang, X | 1 |
| Chai, FN; Li, XG; Li, YF; Ma, WY; Xu, HS; Ye, XL; Zhang, J; Zhou, QD | 1 |
| Clift, MD; De Los Santos, AR; Hedrick, SL; Mori-Quiroz, LM | 1 |
| Chen, H; Huang, P; Li, C; Lu, Q; Luo, C; Su, Z; Tam, C; Tan, L; Wong, K; Xie, J; Xu, Y; Zhu, L | 1 |
| Han, B; Huang, T; Jiang, P; Li, X; Li, Z; Ye, X; Yu, Y | 1 |
| Fu, S; Hong, T; Ni, S; Wang, D | 1 |
| Han, B; Jiang, P; Li, X; Liu, L; Liu, W; Ma, W; Wu, S; Xu, H; Ye, X; Zhang, J | 1 |
| Hu, Y; Huang, W; Meng, X; Wang, L; Wang, P; Wu, J; Xiang, L; Xu, C | 1 |
| Gao, L; Merz, KH; Schmitz, HJ; Schrenk, D | 1 |
| Gao, J; Li, X; Liu, YG; Miao, XZ; Tan, P; Yuan, YY; Zhang, X; Zhang, YL | 1 |
| Choi, YH | 1 |
| Chen, X; Du, GH; Fang, LH; Jia, WH; Qiang, GF; Shi, LL; Wang, NQ; Xu, CY; Yang, XY; Yin, L; Zhang, L | 1 |
| Hu, Y; Huang, W; Jiang, Q; Li, S; Liu, D; Lu, X; Luo, Y; Meng, X; Wang, F; Wang, P; Wu, J; Xiang, L; Zhang, G | 1 |
| Li, M; Li, X; Li, Z; Ma, L; Ma, Z; Zhai, J; Zhang, H; Zhang, Y; Zou, J | 1 |
| Deng, D; Hu, Y; Li, S; Luo, Y; Meng, X; Su, S; Wang, P; Wu, J; Xiang, L | 1 |
| Cai, C; Liu, QH; Shen, J; Shi, S; Wen, N; Xue, L; Yang, Y | 1 |
| Cheong, J; Choi, YH; Hwangbo, H; Kim, GY; Kim, SY; Kim, WJ; Lee, H; Moon, SK; Park, C; Yun, SJ | 1 |
| Sun, S; Wang, P | 1 |
| Ge, J; Li, S; Nan, F; Ren, W; Yang, S; Zhao, Z | 1 |
| Cheong, J; Choi, YH; Hong, SH; Hwangbo, H; Ji, SY; Kim, GY; Kim, MY; Kim, SY; Kwon, CY; Lee, H; Leem, SH | 1 |
| Chen, J; Huang, Z; Li, C; Li, Y; Liang, Y; Liu, J; Luo, C; Ni, C; Su, Z; Wang, Y; Xie, J | 1 |
| Fujinami, D; Hanada, K; Inoue, N; Ishizaki, T; Kawano, M; Kohda, D; Matsuoka, S; Narahara, H; Nishida, Y; Takiguchi-Kawashima, Y; Tanaka, K; Terabayashi, T; Tsumura, H | 1 |
| Chen, X; Liu, C; Qu, S; Wen, X; Yang, Y; Zhang, X | 1 |
| He, Y; Li, M; Wang, J; Zhang, X; Zhao, S; Zheng, N | 1 |
| Cheng, J; Feng, J; Feng, S; Ma, C; Song, W; Wang, R; Xie, L; Zhang, X; Zhao, W | 1 |
| Choi, MJ; Nguyen, LTH; Shin, HM; Yang, IJ | 1 |
| Gu, W; Kong, LY; Li, J; Li, Y; Liu, Y; Wang, KB; Wang, Y; Xia, YZ; Xiao, C; Yan, T; Yang, MH | 1 |
| Guo, Y; Hu, Q; Lu, Q; Luo, Q; Shao, H; Tian, S; Zhang, R; Zhang, T; Zhang, W | 1 |
| He, MF; Hu, C; Liang, JH; Liu, LC; Shen, YN; Song, X; Wang, Y; Xie, Q; Yang, KY; Zhang, CW | 1 |
1 review(s) available for coptisine and berberine
| Article | Year |
|---|---|
Coptisine from Coptis chinensis exerts diverse beneficial properties: A concise review.
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents; Antinematodal Agents; Autophagy; Berberine; Biological Availability; Cardiovascular Diseases; Coptis; Humans; Inflammasomes; Pyroptosis; Signal Transduction | 2019 |
132 other study(ies) available for coptisine and berberine
| Article | Year |
|---|---|
Neuraminidase inhibitory activities of quaternary isoquinoline alkaloids from Corydalis turtschaninovii rhizome.
Topics: Alkaloids; Anti-Bacterial Agents; Clostridium Infections; Clostridium perfringens; Corydalis; Enzyme Inhibitors; Humans; Isoquinolines; Molecular Docking Simulation; Neuraminidase; Rhizome | 2014 |
Studies on the antinephritic effect of plant components (4): Reduction of protein excretion by berberine and coptisine in rats with original-type anti-GBM nephritis.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Berberine; Cholesterol; Creatinine; Dipyridamole; Drug Evaluation, Preclinical; In Vitro Techniques; Male; Nephritis; Plant Extracts; Platelet Aggregation; Proteinuria; Rats; Rats, Sprague-Dawley; Renal Circulation; Thromboxane B2 | 1992 |
[Studies on collagenase inhibitors. IV. Inhibitors of bacterial collagenase in Coptidis rhizoma].
Topics: Berberine; Drugs, Chinese Herbal; Microbial Collagenase | 1991 |
[Quantitative determination of 5 alkaloids in plants of Coptis from China].
Topics: Alkaloids; Berberine; Berberine Alkaloids; Chromatography, Thin Layer; Densitometry; Drugs, Chinese Herbal; Triterpenes | 1989 |
Simultaneous determination of berberine, palmatine and coptisine in crude drugs and oriental pharmaceutical preparations by ion-pair high-performance liquid chromatography.
Topics: Berberine; Berberine Alkaloids; Chromatography, High Pressure Liquid; Medicine, East Asian Traditional | 1982 |
[Study on baths with crude drug. II.: the effects of coptidis rhizoma extracts as skin permeation enhancer].
Topics: Animals; Baths; Berberine; Berberine Alkaloids; Drugs, Chinese Herbal; Fluorouracil; In Vitro Techniques; Male; Rats; Rats, Wistar; Skin Absorption; Solubility; Stimulation, Chemical; Water | 1995 |
Reduction of ACh-induced contraction of rat isolated ileum by coptisine, (+)-caffeoylmalic acid, Chelidonium majus, and Corydalis lutea extracts.
Topics: Acetylcholine; Animals; Berberine; Caffeic Acids; Ileum; In Vitro Techniques; Malates; Muscle Contraction; Muscle, Smooth; Plant Extracts; Plants, Medicinal; Rats | 1996 |
Antispasmodic and relaxant activity of chelidonine, protopine, coptisine, and Chelidonium majus extracts on isolated guinea-pig ileum.
Topics: Alkaloids; Animals; Benzophenanthridines; Berberine; Berberine Alkaloids; Carbachol; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Muscle Relaxation; Papaver; Parasympatholytics; Phenanthridines; Plant Extracts; Plants, Medicinal | 1998 |
Simultaneous determination of baicalin, wogonoside, baicalein, wogonin, berberine, coptisine, palmatine, jateorrhizine and glycyrrhizin in Kampo medicines by ion-pair high-performance liquid chromatography.
Topics: Alkaloids; Berberine; Berberine Alkaloids; Chromatography, High Pressure Liquid; Flavanones; Flavonoids; Glycyrrhizic Acid; Medicine, Kampo | 1999 |
Growth-inhibiting effects of Coptis japonica root-derived isoquinoline alkaloids on human intestinal bacteria.
Topics: Alkaloids; Bacteria; Berberine; Berberine Alkaloids; Humans; Intestinal Mucosa; Isoquinolines; Plant Extracts; Plant Roots | 1999 |
Analysis of coptisine, berberine and palmatine in adulterated Chinese medicine by capillary electrophoresis-electrospray ion trap mass spectrometry.
Topics: Berberine; Berberine Alkaloids; Drug Contamination; Electrophoresis, Capillary; Mass Spectrometry; Medicine, Chinese Traditional; Spectrophotometry, Ultraviolet | 2000 |
Inhibition of dopamine biosynthesis by protoberberine alkaloids in PC12 cells.
Topics: Animals; Berberine; Berberine Alkaloids; Calcium; Dopamine; Dopamine Antagonists; PC12 Cells; Rats; Tyrosine 3-Monooxygenase | 2000 |
Antifeeding activity of isoquinoline alkaloids identified in Coptis japonica roots against Hyphantria cunea (Lepidoptera: Arctiidae) and Agelastica coerulea (Coleoptera: Galerucinae).
Topics: Animals; Berberine; Berberine Alkaloids; Coleoptera; Feeding Behavior; Isoquinolines; Molecular Structure; Moths; Plant Roots; Plants, Medicinal | 2000 |
Coptidis rhizoma inhibits growth and proteases of oral bacteria.
Topics: Actinomyces; Aggregatibacter actinomycetemcomitans; Anti-Infective Agents; Bacteria; Berberine; Berberine Alkaloids; Coptis chinensis; Drugs, Chinese Herbal; Humans; Lactobacillus; Lethal Dose 50; Matrix Metalloproteinase Inhibitors; Microbial Sensitivity Tests; Mouth; Prevotella intermedia; Prevotella nigrescens; Protease Inhibitors; Ranunculaceae; Streptococcus | 2000 |
In vitro cytotoxicity of the protoberberine-type alkaloids.
Topics: Animals; Antineoplastic Agents, Phytogenic; Berberine; Berberine Alkaloids; Brain Neoplasms; Breast Neoplasms; Colonic Neoplasms; Crystallography, X-Ray; Databases, Factual; Doxorubicin; Female; Humans; Lung Neoplasms; Magnetic Resonance Spectroscopy; Mice; Mitomycin; Molecular Structure; Ovarian Neoplasms; Papaver; Plants, Medicinal; Stomach Neoplasms; Structure-Activity Relationship; Tumor Cells, Cultured | 2001 |
Interaction of benzo[c]phenanthridine and protoberberine alkaloids with animal and yeast cells.
Topics: Alkaloids; Antioxidants; Benzophenanthridines; Berberine; Berberine Alkaloids; Cell Division; Cytoskeleton; HeLa Cells; Humans; Isoquinolines; Phenanthridines; Saccharomyces cerevisiae; Schizosaccharomyces | 2001 |
Gastric-mucous membrane protection activity of coptisine derivatives.
Topics: Animals; Berberine; Coptis chinensis; Drugs, Chinese Herbal; Ethanol; Gastric Mucosa; Male; Plant Roots; Rats; Rats, Wistar; Structure-Activity Relationship | 2001 |
Inhibition of type A monoamine oxidase by coptisine in mouse brain.
Topics: Animals; Berberine; Berberine Alkaloids; Binding, Competitive; Brain; Clorgyline; Dialysis; Dose-Response Relationship, Drug; Iproniazid; Kynuramine; Male; Mice; Mice, Inbred ICR; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Structure-Activity Relationship | 2001 |
[Determination of alkaloids in Coptis-Cinnamomum compatibility by capillary electrophoresis].
Topics: Alkaloids; Berberine; Berberine Alkaloids; Cinnamomum; Coptis; Drug Combinations; Drugs, Chinese Herbal; Electrophoresis, Capillary; Plants, Medicinal | 1999 |
Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by a Coptidis Rhizoma extract and protoberberine alkaloids.
Topics: Animals; Berberine; Berberine Alkaloids; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Coptis chinensis; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Enzyme Activation; Nerve Growth Factors; Neurites; PC12 Cells; Rats | 2002 |
[Study on the solubility changes of Rhizoma Coptidis' main chemical constituents influenced by the proportion of Rhizoma Coptidis and Fructus Evodiae].
Topics: Berberine; Berberine Alkaloids; Chromatography, High Pressure Liquid; Coptis; Drug Combinations; Drugs, Chinese Herbal; Evodia; Plant Roots; Plants, Medicinal; Solubility | 2003 |
Improved detection of Coptidis alkaloids by field-amplified sample stacking in capillary electrophoresis.
Topics: Alkaloids; Berberine; Berberine Alkaloids; Coptis; Coptis chinensis; Drugs, Chinese Herbal; Electrophoresis, Capillary; Reference Standards; Reproducibility of Results; Rhizome; Sensitivity and Specificity | 2004 |
[Establishment of the control substance of plant drug and fingerprints of Coptis chinensis].
Topics: Berberine; Berberine Alkaloids; Chromatography, High Pressure Liquid; Coptis; Magnetic Resonance Spectroscopy; Plants, Medicinal; Quality Control | 2004 |
[Quality assessment of Coptis chinensis in China].
Topics: Alkaloids; Berberine; Berberine Alkaloids; China; Chromatography, High Pressure Liquid; Coptis; Ecosystem; Plants, Medicinal; Quality Control; Spectrophotometry, Ultraviolet | 2005 |
Simultaneous determination of four active alkaloids from a traditional Chinese medicine Corydalis saxicola Bunting. (Yanhuanglian) in plasma and urine samples by LC-MS-MS.
Topics: Administration, Oral; Alkaloids; Animals; Berberine; Chromatography, High Pressure Liquid; Corydalis; Humans; Injections, Intravenous; Male; Mass Spectrometry; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity | 2006 |
[Studies on the alkaloids from herb of Corydalis adunca].
Topics: Berberine; Berberine Alkaloids; Corydalis; Plants, Medicinal | 2005 |
Selective inhibition of vascular smooth muscle cell proliferation by coptisine isolated from Coptis rhizoma, one of the crude drugs composing Kampo medicines Unsei-in.
Topics: Animals; Berberine; Cell Cycle; Cell Proliferation; Chromatography, High Pressure Liquid; Coptis; Drugs, Chinese Herbal; HeLa Cells; Humans; Inhibitory Concentration 50; Male; Medicine, Kampo; Melanoma, Experimental; Mice; Muscle, Smooth, Vascular; Rats; Rats, Sprague-Dawley; Rhizome | 2006 |
Analysis of Central European Corydalis species by nonaqueous capillary electrophoresis-electrospray ion trap mass spectrometry.
Topics: Alkaloids; Austria; Berberine; Berberine Alkaloids; Corydalis; Electrophoresis, Capillary; Online Systems; Plant Extracts; Plants, Medicinal; Reproducibility of Results; Sensitivity and Specificity; Solubility; Solvents; Spectrometry, Mass, Electrospray Ionization | 2007 |
High performance liquid chromatography-mass spectrometry analysis of protoberberine alkaloids in medicine herbs.
Topics: Berberine; Berberine Alkaloids; Chromatography, High Pressure Liquid; Coptis chinensis; Drugs, Chinese Herbal; Mass Spectrometry; Molecular Structure; Phellodendron | 2007 |
Simultaneous quantification of three alkaloids of Coptidis Rhizoma in rat urine by high-performance liquid chromatography: application to pharmacokinetic study.
Topics: Administration, Oral; Animals; Berberine; Berberine Alkaloids; Chromatography, High Pressure Liquid; Coptis; Drugs, Chinese Herbal; Female; Male; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Rhizome | 2007 |
[Absorption of coptisine chloride and berberrubine across human intestinal epithelial by using human Caco-2 cell monolayers].
Topics: Absorption; Berberine; Biological Transport; Caco-2 Cells; Cell Membrane Permeability; Chromatography, High Pressure Liquid; Corydalis; Epithelial Cells; Humans; Intestinal Mucosa; Plants, Medicinal | 2007 |
Covalent bonding of azoles to quaternary protoberberine alkaloids.
Topics: Alkaloids; Azoles; Berberine; Berberine Alkaloids; Chemistry, Organic; Crystallography, X-Ray; Magnetic Resonance Spectroscopy; Mass Spectrometry | 2008 |
[Studies on chemical constituents in the anti-myocardial ischemia effective fraction of Corydalis yanhusuo].
Topics: Alkaloids; Berberine; Berberine Alkaloids; Corydalis; Drugs, Chinese Herbal; Plants, Medicinal; Rhizome; Spectrophotometry, Infrared; Technology, Pharmaceutical | 2008 |
Purification of alkaloids from Corydalis yanhusuo W. T. Wang using preparative 2-D HPLC.
Topics: 1-Butanol; Acetates; Acetonitriles; Alkaloids; Berberine; Berberine Alkaloids; Chromatography, High Pressure Liquid; Corydalis; Mass Spectrometry | 2009 |
Investigation of the anti-fungal activity of coptisine on Candida albicans growth by microcalorimetry combined with principal component analysis.
Topics: Antifungal Agents; Berberine; Calorimetry; Candida albicans; Kinetics; Microbial Sensitivity Tests; Principal Component Analysis | 2009 |
[Effect of additives on absorption of Coptis chinensis total alkaloids and pharmacokinetics in mice].
Topics: Absorption; Alkaloids; Animals; Berberine; Chromatography, High Pressure Liquid; Coptis; Diterpenes; Drug Interactions; Female; Food Additives; Half-Life; Male; Mice | 2009 |
Selective regulation of multidrug resistance protein in vascular smooth muscle cells by the isoquinoline alkaloid coptisine.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Berberine; Berberine Alkaloids; Cardiovascular Agents; Cell Line; Cell Line, Tumor; Coptis; Dactinomycin; Drug Resistance, Multiple; Gene Expression Regulation; Genes, MDR; Humans; Membrane Transport Proteins; Mice; Molecular Structure; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Rats; Rhodamines; RNA, Messenger; Up-Regulation | 2010 |
[Simultaneous determination of six alkaloids in Coptis chinensis of different regions by RP-HPLC].
Topics: Alkaloids; Berberine; Berberine Alkaloids; Chromatography, High Pressure Liquid; Coptis; Drugs, Chinese Herbal | 2010 |
Application of 1H-NMR spectroscopy to validation of berberine alkaloid reagents and to chemical evaluation of Coptidis Rhizoma.
Topics: Berberine; Berberine Alkaloids; Chromatography, High Pressure Liquid; Coptis; Magnetic Resonance Spectroscopy; Molecular Structure; Plant Extracts | 2011 |
Intestinal absorption mechanisms of berberine, palmatine, jateorhizine, and coptisine: involvement of P-glycoprotein.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Berberine; Berberine Alkaloids; Biological Transport; Caco-2 Cells; Cyclosporine; Drugs, Chinese Herbal; Humans; Intestinal Absorption; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Propionates; Quinolines; Verapamil | 2011 |
Differential gene expression in rat vascular smooth muscle cells following treatment with coptisine exerts a selective antiproliferative effect.
Topics: Animals; Berberine; Cell Cycle Proteins; Cell Proliferation; Gene Expression; Mice; Muscle Proteins; Muscle, Smooth, Vascular; Nerve Tissue Proteins; Nuclear Proteins; Rats; RNA, Messenger | 2011 |
Ionic liquid sensitized fluorescence determination of four isoquinoline alkaloids.
Topics: Alkaloids; Berberine; Berberine Alkaloids; Ionic Liquids; Isoquinolines; Temperature | 2011 |
Coptisine inhibits RANKL-induced NF-κB phosphorylation in osteoclast precursors and suppresses function through the regulation of RANKL and OPG gene expression in osteoblastic cells.
Topics: Animals; Berberine; Bone Density Conservation Agents; Bone Marrow Cells; Calcitriol; Cell Differentiation; Cell Survival; Cells, Cultured; Coculture Techniques; Dose-Response Relationship, Drug; Gene Expression Regulation; Male; Mice; NF-kappa B; NFATC Transcription Factors; Osteoblasts; Osteoclasts; Osteoprotegerin; Phosphorylation; RANK Ligand; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Transcription Factor RelA | 2012 |
Comparative pharmacokinetics of dehydroevodiamine and coptisine in rat plasma after oral administration of single herbs and Zuojinwan prescription.
Topics: Alkaloids; Animals; Berberine; Coptis; Drug Combinations; Drugs, Chinese Herbal; Evodia; Male; Rats; Rats, Sprague-Dawley; Rhizome | 2011 |
Determination of protoberberine alkaloids in Rhizoma Coptidis by ERETIC ¹H NMR method.
Topics: Berberine; Berberine Alkaloids; Coptis; Limit of Detection; Magnetic Resonance Spectroscopy | 2012 |
Coptisine exert cardioprotective effect through anti-oxidative and inhibition of RhoA/Rho kinase pathway on isoproterenol-induced myocardial infarction in rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antioxidants; Apoptosis; Berberine; Cardiotonic Agents; Isoproterenol; Male; Mitochondria, Heart; Myocardial Infarction; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein | 2012 |
Analysis of the mechanisms underlying the vasorelaxant action of coptisine in rat aortic rings.
Topics: Animals; Aorta, Thoracic; Berberine; Calcium; Coptis; Drugs, Chinese Herbal; Endothelium, Vascular; Humans; In Vitro Techniques; Male; Rats; Rats, Sprague-Dawley; Vasodilation; Vasodilator Agents | 2012 |
Design, synthesis and multidrug resistance reversal activity evaluation of 8-oxocoptisine derivatives.
Topics: Antineoplastic Agents; Berberine; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Design; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Inhibitory Concentration 50; Molecular Structure; Structure-Activity Relationship | 2012 |
[Preparation and stuctural behavior of the inclusion complex of beta-cyclodextrin and coptisine hydrochloride].
Topics: Berberine; beta-Cyclodextrins; Drug Compounding; Drug Stability; Plant Extracts; Solubility; Spectrophotometry, Ultraviolet; Temperature; Time Factors | 2012 |
Analysis of four alkaloids of Coptis chinensis in rat plasma by high performance liquid chromatography with electrochemical detection.
Topics: Administration, Oral; Animals; Berberine; Berberine Alkaloids; Calibration; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Coptis; Coptis chinensis; Drugs, Chinese Herbal; Electrochemical Techniques; Electrodes; Limit of Detection; Rats | 2012 |
[Quantitative analysis of four alkaloids in Xianglian preparations by QAMS method].
Topics: Alkaloids; Berberine; Berberine Alkaloids; Chromatography, High Pressure Liquid; Coptis; Drugs, Chinese Herbal; Evaluation Studies as Topic; Quality Control; Reference Standards | 2011 |
Quality evaluation and species differentiation of Rhizoma coptidis by using proton nuclear magnetic resonance spectroscopy.
Topics: Berberine; Berberine Alkaloids; Coptis; Drugs, Chinese Herbal; Magnetic Resonance Spectroscopy; Multivariate Analysis; Plant Extracts; Principal Component Analysis; Rhizome; Species Specificity | 2012 |
Safety evaluation of main alkaloids from Rhizoma Coptidis.
Topics: 3T3-L1 Cells; Alkaloids; Animals; Berberine; Berberine Alkaloids; Blood Proteins; Body Weight; Coptis; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Female; Hep G2 Cells; Humans; Inhibitory Concentration 50; Lethal Dose 50; Male; Mice; Organ Size; Rats; Rats, Sprague-Dawley; Rhizome | 2013 |
[Classification study of Coptis chinensis based on quantitative physical property characteristics of appearance and internal quality evaluation].
Topics: Berberine; Berberine Alkaloids; Coptis; Drugs, Chinese Herbal; Quality Control | 2012 |
[Simultaneous determination of five alkaloids in Niuhuang Shangqing Tablets by micellar electrokinetic chromatography-mass spectrometry using laurel acyl malic acid ester].
Topics: Alkaloids; Berberine; Chromatography, Micellar Electrokinetic Capillary; Drugs, Chinese Herbal; Esters; Malates; Mass Spectrometry; Tablets | 2012 |
[Screening of the active ingredients in natural products by capillary electrophoresis and high performance liquid chromatography-mass spectrometry].
Topics: Acetylcholinesterase; Alkaloids; Berberine; Berberine Alkaloids; Biological Products; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Electrophoresis, Capillary; Tandem Mass Spectrometry | 2013 |
Coptisine protects rat heart against myocardial ischemia/reperfusion injury by suppressing myocardial apoptosis and inflammation.
Topics: Animals; Apoptosis; Berberine; Cytokines; Disease Models, Animal; Electrocardiography; Enzyme-Linked Immunosorbent Assay; Heart; Inflammation; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; Rats; rho-Associated Kinases; Temperature; Time Factors | 2013 |
[Advance in studies on pharmacological activity of coptisine hydrochloride].
Topics: Animals; Berberine; Cell Differentiation; Cell Proliferation; Drugs, Chinese Herbal; Humans | 2013 |
Facile synthesis of tetrahydroprotoberberine and protoberberine alkaloids from protopines and study on their antibacterial activities.
Topics: Anti-Bacterial Agents; Benzophenanthridines; Berberine; Berberine Alkaloids; Escherichia coli; Isoquinolines; Microbial Sensitivity Tests; Staphylococcus; Structure-Activity Relationship | 2014 |
A new quaternary protoberberine alkaloid isolated from Dicranostigma leptopodum (Maxim) Fedde.
Topics: Berberine; Berberine Alkaloids; Drugs, Chinese Herbal; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Papaveraceae | 2014 |
Unraveling the novel anti-osteosarcoma function of coptisine and its mechanisms.
Topics: Animals; Antigens, CD; Antineoplastic Agents, Phytogenic; Berberine; Bone Neoplasms; Cadherins; Cell Line, Tumor; Cell Proliferation; Female; Humans; Mice; Mice, Inbred BALB C; Neoplasm Invasiveness; Neovascularization, Pathologic; Osteosarcoma | 2014 |
[Microcalorimetric investigation on the interaction of six alkaloids from rhizoma coptidis].
Topics: Alkaloids; Berberine; Berberine Alkaloids; Coptis; Drug Interactions; Drug Synergism; Plants, Medicinal; Quality Control; Rhizome; Shigella dysenteriae | 2013 |
Inhibitory effects of phytochemicals on metabolic capabilities of CYP2D6(*)1 and CYP2D6(*)10 using cell-based models in vitro.
Topics: Berberine; Cell Line, Tumor; Chromatography, High Pressure Liquid; Coumarins; Cyclooctanes; Cyclopentanes; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Furans; Ginkgolides; Hep G2 Cells; Humans; Isoflavones; Kinetics; Lignans; Luteolin; Phytochemicals; Polycyclic Compounds | 2014 |
Pharmacochemistry and integrated pharmacokinetics of six alkaloids after oral administration of huang-lian-jie-du-tang decoction.
Topics: Administration, Oral; Alkaloids; Animals; Berberine; Berberine Alkaloids; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Flavanones; Flavonoids; Glucosides; Iridoids; Molecular Structure; Rats; Rats, Sprague-Dawley | 2014 |
Dynamic monitoring of the cytotoxic effects of protoberberine alkaloids from Rhizoma Coptidis on HepG2 cells using the xCELLigence system.
Topics: Antineoplastic Agents, Phytogenic; Berberine; Berberine Alkaloids; Cell Death; Cisplatin; Coptis; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Electric Impedance; Hep G2 Cells; Hepatoblastoma; Humans; Inhibitory Concentration 50; Liver Neoplasms; Phytotherapy; Rhizome | 2014 |
New synthetic method of 8-oxocoptisine starting from natural quaternary coptisine as anti-ulcerative colitis agent.
Topics: Berberine; Berberine Alkaloids; Colitis, Ulcerative; Ferricyanides; Molecular Structure | 2014 |
The IDO inhibitor coptisine ameliorates cognitive impairment in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Berberine; Brain; Cell Survival; Cognition; Cognition Disorders; Disease Models, Animal; Donepezil; Enzyme Inhibitors; Humans; Indans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Male; Mice, Transgenic; Nootropic Agents; PC12 Cells; Piperidines; Plaque, Amyloid; Presenilin-1; Rats | 2015 |
Suppression of human breast cancer cell metastasis by coptisine in vitro.
Topics: Berberine; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferation; Collagen; Drug Combinations; Female; Humans; Laminin; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Neoplasm Metastasis; Proteoglycans; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Wound Healing | 2014 |
[Effect of different parts, harvesting time and processing technologies on alkaloids content of Coptis chinensis adventitious root].
Topics: Alkaloids; Berberine; Chromatography, High Pressure Liquid; Coptis; Drug Compounding; Plant Roots; Plants, Medicinal; Seasons; Time Factors | 2014 |
Syntheses and structure-activity relationships in cytotoxicities of 13-substituted quaternary coptisine derivatives.
Topics: Berberine; Cell Line, Tumor; Cell Proliferation; Cytotoxins; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Structure-Activity Relationship | 2014 |
Metabolic profiling analysis of berberine, palmatine, jatrorrhizine, coptisine and epiberberine in zebrafish by ultra-high performance liquid chromatography coupled with LTQ Orbitrap mass spectrometer.
Topics: Animals; Berberine; Berberine Alkaloids; Chromatography, High Pressure Liquid; Metabolomics; Models, Animal; Tandem Mass Spectrometry; Zebrafish | 2015 |
A competitive strategy based on cucurbit[7]uril supramolecular interaction for simple and sensitive detection of dibucaine.
Topics: Anesthetics, Local; Berberine; Berberine Alkaloids; Binding, Competitive; Bridged-Ring Compounds; Dibucaine; Fluorescent Dyes; Humans; Hydrogen-Ion Concentration; Imidazoles; Kinetics; Limit of Detection; Solutions; Spectrometry, Fluorescence; Thermodynamics | 2015 |
The safety and anti-hypercholesterolemic effect of coptisine in Syrian golden hamsters.
Topics: Animals; Anticholesteremic Agents; Berberine; Cholesterol; Cricetinae; Diet, High-Fat; Down-Regulation; Female; Hydroxymethylglutaryl CoA Reductases; Hypercholesterolemia; Lipids; Lipoproteins, HDL; Lipoproteins, LDL; Liver; Male; Mesocricetus; RNA, Messenger; Triglycerides | 2015 |
Two-stage fractionation of polar alkaloids from Rhizoma coptidis by countercurrent chromatography considering the strategy of reactive extraction.
Topics: Alkaloids; Berberine; Berberine Alkaloids; Chemical Fractionation; Countercurrent Distribution; Drugs, Chinese Herbal; Plants, Medicinal; Ranunculaceae | 2015 |
13,14-dihydrocoptisine--the genuine alkaloid from Chelidonium majus.
Topics: Alkaloids; Berberine; Berberine Alkaloids; Chelidonium; Molecular Structure; Oxidation-Reduction; Plant Leaves; Plants, Medicinal | 2015 |
Simultaneous quantification and antiatherosclerosis effect of the traditional Korean medicine, Hwangryunhaedok-tang.
Topics: Animals; Antioxidants; Atherosclerosis; Berberine; Berberine Alkaloids; Biphenyl Compounds; Cell Proliferation; Chromatography, High Pressure Liquid; Coptis; Drugs, Chinese Herbal; Flavonoids; Gardenia; Iridoids; Lipoproteins, LDL; Medicine, Korean Traditional; Muscle, Smooth, Vascular; Phellodendron; Phytotherapy; Picrates; Platelet-Derived Growth Factor; Rats; Regression Analysis; Scutellaria | 2015 |
Coptisine attenuates obesity-related inflammation through LPS/TLR-4-mediated signaling pathway in Syrian golden hamsters.
Topics: Animals; Berberine; Body Weight; Cholesterol; Cholesterol, LDL; Coptis; Diet, High-Fat; Disease Models, Animal; Inflammation; Interleukin-6; Lipid Metabolism; Lipid-Linked Proteins; Lipopolysaccharides; Male; Mesocricetus; Molecular Structure; Obesity; Signal Transduction; Toll-Like Receptor 4; Triglycerides; Tumor Necrosis Factor-alpha | 2015 |
Interaction of six protoberberine alkaloids with human organic cation transporters 1, 2 and 3.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Berberine; Berberine Alkaloids; Cells, Cultured; Chromatography, Liquid; Dogs; Humans; Inhibitory Concentration 50; Madin Darby Canine Kidney Cells; Octamer Transcription Factor-3; Organic Cation Transport Proteins; Organic Cation Transporter 1; Organic Cation Transporter 2; Polymorphism, Genetic; Tandem Mass Spectrometry | 2016 |
Pharmacokinetics and Brain Distribution and Metabolite Identification of Coptisine, a Protoberberine Alkaloid with Therapeutic Potential for CNS Disorders, in Rats.
Topics: Animals; Berberine; Bile; Brain; Central Nervous System Diseases; Chromatography, Liquid; Feces; Gastrointestinal Microbiome; Male; Medicine, Chinese Traditional; Microsomes, Liver; Rats, Sprague-Dawley; Tandem Mass Spectrometry | 2015 |
Screening β1AR inhibitors by cell membrane chromatography and offline UPLC/MS method for protecting myocardial ischemia.
Topics: Adrenergic beta-1 Receptor Antagonists; Animals; Apoptosis; Berberine; Binding, Competitive; Cell Membrane; CHO Cells; Chromatography, High Pressure Liquid; Coptis; Cricetulus; Disease Models, Animal; Male; Malondialdehyde; Mass Spectrometry; Metoprolol; Myocardial Infarction; Myocardium; Myocytes, Cardiac; Phytotherapy; Plant Extracts; Plants, Medicinal; Rats, Wistar; Receptors, Adrenergic, beta-1; Superoxide Dismutase; Transfection | 2015 |
[Regulatory effect of coptisine on key genes involved in cholesterol metabolism].
Topics: Berberine; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Drugs, Chinese Herbal; Gene Expression Regulation, Enzymologic; Hep G2 Cells; Humans; Hydroxymethylglutaryl CoA Reductases; Receptors, LDL; Triglycerides | 2015 |
Synthesis and Structure-Activity Relationships of Quaternary Coptisine Derivatives as Potential Anti-ulcerative Colitis Agents.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Berberine; Cell Line; Colitis, Ulcerative; Colon; Dextran Sulfate; DNA-Binding Proteins; Mice, Inbred C57BL; Muscle Contraction; Muscle, Smooth; Rats; Regulatory Factor X Transcription Factors; Stereoisomerism; Structure-Activity Relationship; Transcription Factors; Transcriptional Activation; X-Box Binding Protein 1 | 2015 |
HPLC-PDA Method for Simultaneous Determination of Nine Marker Components in Banhasasim-Tang.
Topics: Acetonitriles; Berberine; Berberine Alkaloids; Chromatography, High Pressure Liquid; Flavanones; Flavonoids; Glucosides; Glycyrrhizic Acid; Humans; Limit of Detection; Medicine, Korean Traditional; Observer Variation; Pinellia; Plants, Medicinal; Reproducibility of Results; Solvents; Trifluoroacetic Acid; Water | 2016 |
In vitro studies of antifibrotic and cytoprotective effects elicited by proto-berberine alkaloids in human dermal fibroblasts.
Topics: Berberine; Berberine Alkaloids; Cell Proliferation; Cells, Cultured; Collagen; Cytoprotection; Fibroblasts; Fibrosis; Free Radicals; Humans; Hydrogen Peroxide; Interleukin-1beta; Interleukin-6; Mitochondria; Oxidoreductases; Protective Agents; Transforming Growth Factor beta1 | 2015 |
Synthesis and Structure-Activity Relationships of N-Dihydrocoptisine-8-ylidene Aromatic Amines and N-Dihydrocoptisine-8-ylidene Aliphatic Amides as Antiulcerative Colitis Agents Targeting XBP1.
Topics: Amides; Amines; Animals; Berberine; Colitis, Ulcerative; DNA-Binding Proteins; Male; Molecular Structure; Regulatory Factor X Transcription Factors; Structure-Activity Relationship; Transcription Factors | 2016 |
Coptisine from Coptis chinensis inhibits production of inflammatory mediators in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells.
Topics: Animals; Berberine; Coptis; Edema; Enzyme Activation; Gene Expression Regulation; Inflammation Mediators; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Macrophages; Mice; Mitogen-Activated Protein Kinases; Nitric Oxide; Nitric Oxide Synthase Type II; Proto-Oncogene Proteins c-akt; Rats; RAW 264.7 Cells; RNA, Messenger; Signal Transduction; Toll-Like Receptor 4 | 2016 |
Versatile methods for synthesizing organic acid salts of quaternary berberine-type alkaloids as anti-ulcerative colitis agents.
Topics: Berberine; Colitis, Ulcerative; Hydrastis; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Regulatory Factor X Transcription Factors; Salts | 2016 |
Coptisine Prevented IL-β-Induced Expression of Inflammatory Mediators in Chondrocytes.
Topics: Anti-Inflammatory Agents; Berberine; Cells, Cultured; Chondrocytes; Cyclooxygenase 2; Humans; Inflammation Mediators; Interleukin-1beta; NF-kappa B; Nitric Oxide Synthase Type II | 2016 |
Activation of Akt and JNK/Nrf2/NQO1 pathway contributes to the protective effect of coptisine against AAPH-induced oxidative stress.
Topics: Amidines; Animals; Antioxidants; Berberine; Dose-Response Relationship, Drug; Embryo, Nonmammalian; Enzyme Activation; Glutathione; Glutathione Peroxidase; Heart Rate; Hep G2 Cells; Hepatocytes; Humans; JNK Mitogen-Activated Protein Kinases; Lipid Peroxidation; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Oxidants; Oxidative Stress; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; Superoxide Dismutase; Zebrafish; Zebrafish Proteins | 2017 |
Pharmacokinetics and tissue distribution of coptisine in rats after oral administration by liquid chromatography-mass spectrometry.
Topics: Administration, Oral; Animals; Berberine; Chromatography, Liquid; Dose-Response Relationship, Drug; Male; Mass Spectrometry; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2017 |
High-throughput screening of triplex DNA binders from complicated samples by 96-well pate format in conjunction with peak area-fading UHPLC-Orbitrap MS.
Topics: Berberine; Berberine Alkaloids; Chromatography, High Pressure Liquid; Coptis; DNA; High-Throughput Screening Assays; Mass Spectrometry; Phellodendron; Reproducibility of Results | 2017 |
Coptisine from Rhizoma Coptidis Suppresses HCT-116 Cells-related Tumor Growth in vitro and in vivo.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Araceae; Berberine; Cell Proliferation; Colorectal Neoplasms; Disease Models, Animal; HCT116 Cells; Heterografts; Humans; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Treatment Outcome | 2017 |
Expression and functional activity of bitter taste receptors in primary renal tubular epithelial cells and M-1 cells.
Topics: Animals; Berberine; Calcium; Cell Line; Cells, Cultured; Epithelial Cells; Gene Expression Regulation; Intestine, Small; Kidney Tubules; Mice; Quinolizines; Receptors, G-Protein-Coupled; Taste | 2017 |
Coptisine-induced cell cycle arrest at G2/M phase and reactive oxygen species-dependent mitochondria-mediated apoptosis in non-small-cell lung cancer A549 cells.
Topics: A549 Cells; Apoptosis; Berberine; Carcinoma, Non-Small-Cell Lung; Cell Cycle Checkpoints; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Mitochondria; Neoplasm Proteins; Reactive Oxygen Species | 2017 |
Small molecule induced poly(A) single strand to self-structure conformational switching: evidence for the prominent role of H-bonding interactions.
Topics: Berberine; Calorimetry, Differential Scanning; Circular Dichroism; Hydrogen Bonding; Microscopy, Atomic Force; Models, Molecular; Molecular Conformation; Poly A | 2017 |
Coptisine protects cardiomyocyte against hypoxia/reoxygenation-induced damage via inhibition of autophagy.
Topics: Animals; Apoptosis; Berberine; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Hypoxia; Myocardial Reperfusion Injury; Myocytes, Cardiac; Oxygen; Rats; Structure-Activity Relationship | 2017 |
Anti-inflammatory activity of coptisine free base in mice through inhibition of NF-κB and MAPK signaling pathways.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents; Berberine; Capillary Permeability; Dinoprostone; Dose-Response Relationship, Drug; Edema; Female; Gene Expression Regulation; Interleukin-1beta; Interleukin-6; Male; MAP Kinase Signaling System; Mice; NF-kappa B; Tumor Necrosis Factor-alpha | 2017 |
Neuroprotective Effect of Corydalis ternata Extract and Its Phytochemical Quantitative Analysis.
Topics: Acetylcholinesterase; Berberine; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; Corydalis; Free Radical Scavengers; Humans; Hydrogen Peroxide; Neuroprotective Agents; Oxidative Stress; Plant Extracts; Plant Tubers | 2017 |
Comparative pharmacokinetics study of five alkaloids in rat plasma and related compound-herb interactions mechanism after oral administration of Shuanghua Baihe tablets.
Topics: Administration, Oral; Alkaloids; Animals; Berberine; Berberine Alkaloids; Chromatography, Liquid; Drugs, Chinese Herbal; Medicine, Chinese Traditional; Rats; Tablets; Tandem Mass Spectrometry | 2018 |
Role of the Benzodioxole Group in the Interactions between the Natural Alkaloids Chelerythrine and Coptisine and the Human Telomeric G-Quadruplex DNA. A Multiapproach Investigation.
Topics: Alkaloids; Benzodioxoles; Benzophenanthridines; Berberine; Berberine Alkaloids; Crystallography, X-Ray; DNA; G-Quadruplexes; Humans; Isoquinolines; Ligands | 2017 |
Protective effect of coptisine free base on indomethacin-induced gastric ulcers in rats: Characterization of potential molecular mechanisms.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Berberine; Cyclooxygenase 1; Cyclooxygenase 2; Disease Models, Animal; Gastric Mucosa; Indomethacin; Interleukin-1beta; Lansoprazole; Male; p38 Mitogen-Activated Protein Kinases; Rats; Stomach Ulcer; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2018 |
Protective effect of Coptisine from Rhizoma Coptidis on LPS/D-GalN-induced acute liver failure in mice through up-regulating expression of miR-122.
Topics: Animals; Berberine; Coptis chinensis; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Galactosamine; Gene Expression; Hep G2 Cells; Humans; Lipopolysaccharides; Liver Failure, Acute; Mice; MicroRNAs; Protective Agents; Random Allocation; Treatment Outcome; Up-Regulation | 2018 |
Construction of an optimized method for quality evaluation and species discrimination of Coptidis Rhizoma by ion-pair high performance liquid chromatography combined with response surface methodology.
Topics: Alkaloids; Berberine; Berberine Alkaloids; Chromatography, High Pressure Liquid; Coptis; Drugs, Chinese Herbal; Ions; Reference Standards; Rhizome | 2018 |
Coptisine, a natural alkaloid from Coptidis Rhizoma, inhibits plasmodium falciparum dihydroorotate dehydrogenase.
Topics: Alkaloids; Berberine; Binding Sites; Catalytic Domain; Coptis; Dihydroorotate Dehydrogenase; Drugs, Chinese Herbal; Enzyme Inhibitors; Humans; Hydrogen Bonding; Kinetics; Molecular Docking Simulation; Oxidoreductases Acting on CH-CH Group Donors; Plasmodium falciparum; Protozoan Proteins; Recombinant Proteins | 2018 |
Novel Inhibitor Discovery of
Topics: Aminoacyltransferases; Bacterial Adhesion; Bacterial Proteins; Berberine; Cysteine Endopeptidases; Molecular Dynamics Simulation; Staphylococcus aureus | 2018 |
Coptisine from Rhizoma coptidis exerts an anti-cancer effect on hepatocellular carcinoma by up-regulating miR-122.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Berberine; Cell Movement; Cell Survival; Drugs, Chinese Herbal; Hep G2 Cells; Humans; Liver Neoplasms; Male; Mice, Inbred BALB C; Mice, Nude; MicroRNAs; Transfection; Xenograft Model Antitumor Assays | 2018 |
A Unified Strategy for the Syntheses of the Isoquinolinium Alkaloids Berberine, Coptisine, and Jatrorrhizine.
Topics: Alkylation; Anti-Bacterial Agents; Berberine; Biological Products; Drug Discovery; Humans; Molecular Structure; Oxidation-Reduction; Quinolinium Compounds; Stereoisomerism | 2018 |
Coptisine-induced inhibition of Helicobacter pylori: elucidation of specific mechanisms by probing urease active site and its maturation process.
Topics: Anti-Bacterial Agents; Berberine; Catalytic Domain; Dose-Response Relationship, Drug; Enzyme Inhibitors; Helicobacter pylori; Hydrogen-Ion Concentration; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship; Urease | 2018 |
Coptisine-induced apoptosis in human colon cancer cells (HCT-116) is mediated by PI3K/Akt and mitochondrial-associated apoptotic pathway.
Topics: Animals; Apoptosis; Berberine; Cell Movement; Cell Proliferation; Cell Survival; Colorectal Neoplasms; Cytochromes c; HCT116 Cells; Humans; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred BALB C; Mice, Nude; Mitochondria; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction | 2018 |
Coptisine Suppresses Mast Cell Degranulation and Ovalbumin-Induced Allergic Rhinitis.
Topics: Animals; Berberine; beta-N-Acetylhexosaminidases; Cell Degranulation; Cell Line; Disease Models, Animal; Histamine; Immunoglobulin E; Interleukin-4; Mast Cells; Mice; Ovalbumin; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rhinitis, Allergic; Tumor Necrosis Factor-alpha | 2018 |
8-Cetylcoptisine, a new coptisine derivative, induces mitochondria-dependent apoptosis and G0/G1 cell cycle arrest in human A549 cells.
Topics: A549 Cells; Animals; Apoptosis; Berberine; Body Weight; Caspase 3; Cell Line, Tumor; Cyclin D; Cyclin-Dependent Kinase 2; G1 Phase Cell Cycle Checkpoints; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Mitochondria; Neoplasms; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Transplantation, Heterologous | 2019 |
Pharmacokinetic-Pharmacodynamic Modeling for Coptisine Challenge of Inflammation in LPS-Stimulated Rats.
Topics: Animals; Anti-Inflammatory Agents; Berberine; Lipopolysaccharides; Lung; Male; Models, Biological; Nitric Oxide; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2019 |
Characterization of the cytotoxicity of selected Chelidonium alkaloids in rat hepatocytes.
Topics: Alkaloids; Animals; Benzophenanthridines; Berberine; Cells, Cultured; Chelidonium; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Glutathione; Hepatocytes; Isoquinolines; Male; Molecular Structure; Primary Cell Culture; Rats, Wistar; Structure-Activity Relationship | 2019 |
Coptisine suppresses proliferation and inhibits metastasis in human pancreatic cancer PANC-1 cells.
Topics: Apoptosis; Berberine; Cell Line, Tumor; Cell Proliferation; Humans; Molecular Structure; Pancreatic Neoplasms | 2020 |
Activation of the Nrf2/HO-1 signaling pathway contributes to the protective effects of coptisine against oxidative stress-induced DNA damage and apoptosis in HaCaT keratinocytes.
Topics: Apoptosis; Berberine; Cell Line; DNA Damage; Heme Oxygenase-1; Humans; Hydrogen Peroxide; Keratinocytes; NF-E2-Related Factor 2; Oxidative Stress; Reactive Oxygen Species; Signal Transduction | 2019 |
Glucose consumption assay discovers coptisine with beneficial effect on diabetic mice.
Topics: AMP-Activated Protein Kinases; Animals; Berberine; Blood Glucose; Diabetes Mellitus, Experimental; Enzyme Activation; Extracellular Space; Hep G2 Cells; Humans; Hypoglycemic Agents; Liver; Male; Mice; Mitochondria; Muscle, Skeletal; Rats | 2019 |
Coptisine from Coptis chinensis blocks NLRP3 inflammasome activation by inhibiting caspase-1.
Topics: Animals; Anti-Inflammatory Agents; Berberine; Caspase 1; Caspase Inhibitors; Coptis; Edema; Gout; Interleukin-1beta; Lipopolysaccharides; Male; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; RAW 264.7 Cells | 2019 |
Coptisine ameliorates renal injury in diabetic rats through the activation of Nrf2 signaling pathway.
Topics: Animals; Berberine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Heme Oxygenase (Decyclizing); Kidney; Male; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Protective Agents; Rats, Sprague-Dawley; Signal Transduction | 2020 |
Coptisine, a protoberberine alkaloid, relaxes mouse airway smooth muscle via blockade of VDLCCs and NSCCs.
Topics: Animals; Berberine; Bronchodilator Agents; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Signaling; In Vitro Techniques; Male; Membrane Potentials; Mice, Inbred BALB C; Muscle Relaxation; Muscle, Smooth; Trachea | 2020 |
Induction of Apoptosis by Coptisine in Hep3B Hepatocellular Carcinoma Cells through Activation of the ROS-Mediated JNK Signaling Pathway.
Topics: Apoptosis; Berberine; Carcinoma, Hepatocellular; Caspase 3; Cell Line, Tumor; Humans; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Neoplasm Recurrence, Local; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species | 2020 |
Coptisine alleviates ischemia/reperfusion-induced myocardial damage by regulating apoptosis-related proteins.
Topics: Animals; Apoptosis Regulatory Proteins; Berberine; Cell Hypoxia; Cell Proliferation; Male; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; Oxygen; Rats, Sprague-Dawley | 2020 |
Red Emissive Carbon Dots Prepared from Polymers as an Efficient Nanocarrier for Coptisine Delivery in vivo and in vitro.
Topics: Animals; Antineoplastic Agents; Berberine; Carbon; Cell Proliferation; Dose-Response Relationship, Drug; Drug Carriers; Drug Delivery Systems; Drug Screening Assays, Antitumor; Female; Fluorescent Dyes; Humans; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Structure; Nanoparticles; Polymers; Quantum Dots; Structure-Activity Relationship; Tumor Cells, Cultured | 2021 |
Coptisine induces autophagic cell death through down-regulation of PI3K/Akt/mTOR signaling pathway and up-regulation of ROS-mediated mitochondrial dysfunction in hepatocellular carcinoma Hep3B cells.
Topics: Antineoplastic Agents; Autophagy; Berberine; Carcinoma, Hepatocellular; Cell Line, Tumor; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Lysosomes; Mitochondria; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; TOR Serine-Threonine Kinases; Up-Regulation | 2021 |
Coptisine ameliorates DSS-induced ulcerative colitis via improving intestinal barrier dysfunction and suppressing inflammatory response.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Apoptosis Regulatory Proteins; Berberine; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Inflammation Mediators; Intestinal Mucosa; Male; Mice, Inbred C57BL; Permeability; Tight Junction Proteins; Tight Junctions | 2021 |
The benzylisoquinoline alkaloids, berberine and coptisine, act against camptothecin-resistant topoisomerase I mutants.
Topics: Antineoplastic Agents, Phytogenic; Berberine; Camptothecin; Cell Line, Tumor; DNA Breaks, Double-Stranded; DNA Replication; DNA Topoisomerases, Type I; Drug Resistance, Neoplasm; Herbal Medicine; Humans; Topoisomerase I Inhibitors | 2021 |
Coptisine induces G2/M arrest in esophageal cancer cell via the inhibition of p38/ERK1/2/claudin-2 signaling pathway.
Topics: Antineoplastic Agents; Berberine; CDC2 Protein Kinase; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Claudin-2; Cyclin B1; Esophageal Neoplasms; G2 Phase Cell Cycle Checkpoints; Humans; Imidazoles; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Pyrazoles; Pyridines; Pyrroles; Signal Transduction | 2021 |
Coptisine: A natural plant inhibitor of ruminal bacterial urease screened by molecular docking.
Topics: Animals; Berberine; Molecular Docking Simulation; Rumen; Urea; Urease | 2022 |
Biological Response Profiling Reveals the Functional Differences of Main Alkaloids in Rhizoma Coptidis.
Topics: 3T3-L1 Cells; Animals; Berberine; Berberine Alkaloids; Cell Cycle; Cell Proliferation; Chromatography, High Pressure Liquid; Coptis; Coptis chinensis; Drugs, Chinese Herbal; Gene Expression Regulation; Hep G2 Cells; Humans; Mice; RAW 264.7 Cells; Rhizome; Signal Transduction; Transcriptome | 2021 |
Coptisine Alleviates Imiquimod-Induced Psoriasis-like Skin Lesions and Anxiety-like Behavior in Mice.
Topics: Animals; Anxiety; Behavior, Animal; Berberine; Imiquimod; Male; Mice; Mice, Inbred BALB C; Psoriasis | 2022 |
Structural insight into the bulge-containing KRAS oncogene promoter G-quadruplex bound to berberine and coptisine.
Topics: Adenine; Berberine; G-Quadruplexes; Genes, ras; Humans; Ligands; Proto-Oncogene Proteins p21(ras); RNA, Messenger | 2022 |
Antibacterial activity mechanism of coptisine against
Topics: Anti-Bacterial Agents; Berberine; Humans; Pasteurella Infections; Pasteurella multocida | 2023 |
Coptisine Inhibits Influenza Virus Replication by Upregulating p21.
Topics: Antiviral Agents; Berberine; Humans; Influenza, Human; Protein Serine-Threonine Kinases; Virus Replication | 2023 |