Compounds > coproporphyrin i
Page last updated: 2024-08-24

coproporphyrin i and rifampin

coproporphyrin i has been researched along with rifampin in 14 studies

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's8 (57.14)24.3611
2020's6 (42.86)2.80

Authors

AuthorsStudies
Bednarczyk, D; Boiselle, C1
Chen, W; Cheng, Y; Dai, J; Freeden, C; Humphreys, WG; Lai, Y; Liu, T; Marathe, P; Shen, H; Zhang, Y1
Cheng, Y; Dai, J; Date, O; Gaud, N; Holenarsipur, VK; Humphreys, WG; Lai, Y; Langish, R; Mandlekar, S; Marathe, P; Murugesan, S; Rajanna, P; Selvam, S; Shen, H; Shipkova, P1
Chen, W; Drexler, DM; Gan, J; Holenarsipur, VK; Humphreys, WG; Lai, Y; Langish, R; Mandlekar, S; Marathe, P; Shen, H; Shields, EE; Sidik, K1
Barnett, S; Galetin, A; Humphreys, WG; Lai, Y; Ménochet, K; Ogungbenro, K; Shen, H1
Burrrell, R; Easter, J; Kadiyala, P; Kandoussi, H; Lai, Y; Langish, R; Marathe, P; Mariannino, T; Paterson, P; Pillutla, R; Santockyte, R; Shah, K; Shen, H; Shipkova, P; Zeng, J; Zhang, Y1
Christopher, L; Garimella, T; Garonzik, S; Gong, J; Humphreys, WG; Kandoussi, H; Lai, Y; Perera, V; Shen, H1
Asaumi, R; Imawaka, H; Kusuhara, H; Lee, W; Menzel, K; Nunoya, KI; Sugiyama, Y1
Fancher, RM; Gan, J; Gu, X; Hong, Y; Lai, Y; Shen, H; Sinz, M; Tian, Y; Wang, L1
Chen, C; Chen, SJ; Chen, XQ; Fancher, RM; Puszczalo, PD; Shen, H; Shuster, DJ; Sinz, M; Yang, Z; Zhang, Y1
Chu, X; Fancourt, C; Iwamoto, M; Lassman, M; Marceau West, R; McCrea, JB; Menzel, K; Mostoller, K; Robbins, JA; Stoch, SA; Witter, R; Zhao, T1
Bessho, K; Shigemi, R; Takubo, H; Watari, R1
Chu, X; Galetin, A; Ogungbenro, K; Scotcher, D; Takita, H; Yee, KL1
Aoki, Y; Chiba, K; Kusuhara, H; Mochizuki, T; Rodrigues, AD; Sugiyama, Y; Yoshikado, T1

Trials

1 trial(s) available for coproporphyrin i and rifampin

ArticleYear
Coproporphyrins in Plasma and Urine Can Be Appropriate Clinical Biomarkers to Recapitulate Drug-Drug Interactions Mediated by Organic Anion Transporting Polypeptide Inhibition.
    The Journal of pharmacology and experimental therapeutics, 2016, Volume: 358, Issue:3

    Topics: Adult; Biomarkers; Coproporphyrins; Drug Interactions; Humans; Male; Middle Aged; Organic Anion Transporters; Rifampin; Rosuvastatin Calcium; Young Adult

2016

Other Studies

13 other study(ies) available for coproporphyrin i and rifampin

ArticleYear
Organic anion transporting polypeptide (OATP)-mediated transport of coproporphyrins I and III.
    Xenobiotica; the fate of foreign compounds in biological systems, 2016, Volume: 46, Issue:5

    Topics: Animals; Area Under Curve; Biological Transport; Biomarkers; CHO Cells; Coproporphyrins; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Drug Interactions; HEK293 Cells; Hepatocytes; Humans; Liver; Liver-Specific Organic Anion Transporter 1; Mass Spectrometry; Mutation; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Rifampin; Serum Albumin, Bovine; Solute Carrier Organic Anion Transporter Family Member 1B3

2016
Coproporphyrins I and III as Functional Markers of OATP1B Activity: In Vitro and In Vivo Evaluation in Preclinical Species.
    The Journal of pharmacology and experimental therapeutics, 2016, Volume: 357, Issue:2

    Topics: Animals; Area Under Curve; Coproporphyrins; Cyclosporine; HEK293 Cells; Hepatocytes; Humans; Liver-Specific Organic Anion Transporter 1; Macaca fascicularis; Mice; Mice, Knockout; Organic Anion Transporters; Rifampin; Rosuvastatin Calcium

2016
Comparative Evaluation of Plasma Bile Acids, Dehydroepiandrosterone Sulfate, Hexadecanedioate, and Tetradecanedioate with Coproporphyrins I and III as Markers of OATP Inhibition in Healthy Subjects.
    Drug metabolism and disposition: the biological fate of chemicals, 2017, Volume: 45, Issue:8

    Topics: Adolescent; Adult; Area Under Curve; Bile Acids and Salts; Biological Transport; Biomarkers; Cell Line; Coproporphyrins; Dehydroepiandrosterone Sulfate; Drug Interactions; Healthy Volunteers; HEK293 Cells; Humans; Male; Middle Aged; Organic Anion Transporters; Palmitic Acids; Rifampin; Rosuvastatin Calcium; Young Adult

2017
Gaining Mechanistic Insight Into Coproporphyrin I as Endogenous Biomarker for OATP1B-Mediated Drug-Drug Interactions Using Population Pharmacokinetic Modeling and Simulation.
    Clinical pharmacology and therapeutics, 2018, Volume: 104, Issue:3

    Topics: Antibiotics, Antitubercular; Biomarkers, Pharmacological; Computer Simulation; Coproporphyrins; Drug Interactions; Genotype; Hepatocytes; Humans; Liver-Specific Organic Anion Transporter 1; Male; Models, Biological; Nonlinear Dynamics; Pharmacogenomic Variants; Rifampin; Risk Assessment; Rosuvastatin Calcium

2018
UHPLC-MS/MS bioanalysis of human plasma coproporphyrins as potential biomarkers for organic anion-transporting polypeptide-mediated drug interactions.
    Bioanalysis, 2018, May-01, Volume: 10, Issue:9

    Topics: Biomarkers, Pharmacological; Chromatography, High Pressure Liquid; Coproporphyrins; Drug Design; Drug Interactions; Humans; Organic Anion Transporters; Rifampin; Rosuvastatin Calcium; Tandem Mass Spectrometry

2018
Further Studies to Support the Use of Coproporphyrin I and III as Novel Clinical Biomarkers for Evaluating the Potential for Organic Anion Transporting Polypeptide 1B1 and OATP1B3 Inhibition.
    Drug metabolism and disposition: the biological fate of chemicals, 2018, Volume: 46, Issue:8

    Topics: Adult; Biological Transport; Biomarkers; Coproporphyrins; Drug Interactions; Genotype; Humans; Liver-Specific Organic Anion Transporter 1; Male; Middle Aged; Organic Anion Transporters; Rifampin; Solute Carrier Organic Anion Transporter Family Member 1B3; Young Adult

2018
Expanded Physiologically-Based Pharmacokinetic Model of Rifampicin for Predicting Interactions With Drugs and an Endogenous Biomarker via Complex Mechanisms Including Organic Anion Transporting Polypeptide 1B Induction.
    CPT: pharmacometrics & systems pharmacology, 2019, Volume: 8, Issue:11

    Topics: Biomarkers; Carbamates; Computer Simulation; Coproporphyrins; Drug Interactions; Glyburide; Humans; Models, Biological; Organic Anion Transporters; Piperidines; Rifampin

2019
Absorption and Disposition of Coproporphyrin I (CPI) in Cynomolgus Monkeys and Mice: Pharmacokinetic Evidence to Support the Use of CPI to Inform the Potential for Organic Anion-Transporting Polypeptide Inhibition.
    Drug metabolism and disposition: the biological fate of chemicals, 2020, Volume: 48, Issue:8

    Topics: Administration, Intravenous; Administration, Oral; Animals; Area Under Curve; Biological Availability; Biomarkers; Coproporphyrins; Cyclosporine; Drug Evaluation, Preclinical; Drug Interactions; Half-Life; Intestinal Absorption; Kidney; Liver; Liver-Specific Organic Anion Transporter 1; Macaca fascicularis; Male; Mice; Rifampin; Tissue Distribution

2020
Absence of OATP1B (Organic Anion-Transporting Polypeptide) Induction by Rifampin in Cynomolgus Monkeys: Determination Using the Endogenous OATP1B Marker Coproporphyrin and Tissue Gene Expression.
    The Journal of pharmacology and experimental therapeutics, 2020, Volume: 375, Issue:1

    Topics: Animals; Biomarkers; Coproporphyrins; Female; Gene Expression; Hydroxycholesterols; Intestine, Small; Kidney; Liver; Macaca fascicularis; Male; Rifampin; Solute Carrier Organic Anion Transporter Family Member 1B3

2020
Acute and Chronic Effects of Rifampin on Letermovir Suggest Transporter Inhibition and Induction Contribute to Letermovir Pharmacokinetics.
    Clinical pharmacology and therapeutics, 2022, Volume: 111, Issue:3

    Topics: Acetates; Adolescent; Adult; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biomarkers; Coproporphyrins; Cytochrome P-450 CYP3A; Drug Interactions; Female; Hepatocytes; Humans; Liver-Specific Organic Anion Transporter 1; Middle Aged; Organic Anion Transporters; Quinazolines; Rifampin; Solute Carrier Organic Anion Transporter Family Member 1B3; Young Adult

2022
Quantitative prediction of OATP1B-mediated drug-drug interactions using endogenous biomarker coproporphyrin I.
    Xenobiotica; the fate of foreign compounds in biological systems, 2022, Volume: 52, Issue:4

    Topics: Biomarkers; Coproporphyrins; Drug Interactions; Liver-Specific Organic Anion Transporter 1; Rifampin

2022
Coproporphyrin I as an Endogenous Biomarker to Detect Reduced OATP1B Activity and Shift in Elimination Route in Chronic Kidney Disease.
    Clinical pharmacology and therapeutics, 2022, Volume: 112, Issue:3

    Topics: Biomarkers; Coproporphyrins; Drug Interactions; Humans; Liver-Specific Organic Anion Transporter 1; Organic Anion Transporters; Prospective Studies; Renal Insufficiency, Chronic; Rifampin

2022
Cluster Gauss-Newton method analyses of PBPK model parameter combinations of coproporphyrin-I based on OATP1B-mediated rifampicin interaction studies.
    CPT: pharmacometrics & systems pharmacology, 2022, Volume: 11, Issue:10

    Topics: Biomarkers; Coproporphyrins; Drug Interactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Organic Anion Transporters; Rifampin

2022