concanavalin-a has been researched along with tanshinone* in 1 studies
1 other study(ies) available for concanavalin-a and tanshinone
| Article | Year |
|---|---|
Tanshinone IIA protects against immune-mediated liver injury through activation of T-cell subsets and regulation of cytokines.
Tanshione IIA (TSN) is the major active component of Salvia miltiorrhiza, a traditional Chinese Medicine. TSN protects against antioxidant-induced liver injury, although the exact mechanism is not well understood.. In this study, the protective effects of TSN was examined by enzyme-linked immunosorbent assay (ELISA) and histochemistry of several cytokines.. TSN is found to significantly reduce plasma alanin aminotransferase and aspartate amino transferase levels in mice with concanavalin A-induced immune-mediated liver injury. TSN increases T lymphocyte subset CD3+, CD4+ and CD8+ ratios.Also, TSN significantly reduces inflammatory cytokines, including interleukin-2, interleukin-4, interferon-gamma and tumor necrosis factor alpha, while elevates anti-inflammatory cytokine, interleukin-10.. TSN may provide a potential drug candidate for liver injury therapeutics. Topics: Abietanes; Alanine Transaminase; Animals; Aspartate Aminotransferases; Concanavalin A; Cytokines; Liver; Lymphocyte Activation; Male; Mice; Phenanthrenes; T-Lymphocyte Subsets | 2010 |