concanavalin-a and idebenone

concanavalin-a has been researched along with idebenone* in 1 studies

Other Studies

1 other study(ies) available for concanavalin-a and idebenone

Article	Year
Potentiation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-selective glutamate receptor function by a nootropic drug, idebenone. Biological & pharmaceutical bulletin, 1994, Volume: 17, Issue:1 Effect of idebenone on the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-selective glutamate receptor was evaluated using Xenopus oocytes injected with RNAs encoding mouse alpha 1 and alpha 2 AMPA receptors. Concanavalin A augmented current responses of the RNA-injected oocytes to glutamate, kainate, and AMPA and these responses were further potentiated by 100 microM idebenone. The minimum concentration of idebenone that gave a significant potentiation was 10 microM for glutamate. These results suggest that idebenone acts on AMPA-selective glutamate receptor channels composed of alpha 1 and alpha 2 subunits. Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzoquinones; Concanavalin A; Dose-Response Relationship, Drug; Electrophysiology; Female; Glutamates; Glutamic Acid; Oocytes; Receptors, Glutamate; RNA, Complementary; Ubiquinone; Xenopus laevis	1994

Article

Year

Potentiation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-selective glutamate receptor function by a nootropic drug, idebenone.

Biological & pharmaceutical bulletin, 1994, Volume: 17, Issue:1

Effect of idebenone on the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-selective glutamate receptor was evaluated using Xenopus oocytes injected with RNAs encoding mouse alpha 1 and alpha 2 AMPA receptors. Concanavalin A augmented current responses of the RNA-injected oocytes to glutamate, kainate, and AMPA and these responses were further potentiated by 100 microM idebenone. The minimum concentration of idebenone that gave a significant potentiation was 10 microM for glutamate. These results suggest that idebenone acts on AMPA-selective glutamate receptor channels composed of alpha 1 and alpha 2 subunits.

Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzoquinones; Concanavalin A; Dose-Response Relationship, Drug; Electrophysiology; Female; Glutamates; Glutamic Acid; Oocytes; Receptors, Glutamate; RNA, Complementary; Ubiquinone; Xenopus laevis

1994