concanavalin-a and hispidin

concanavalin-a has been researched along with hispidin* in 1 studies

Other Studies

1 other study(ies) available for concanavalin-a and hispidin

Article	Year
Inhibition of chemiluminescence response of human mononuclear cells and suppression of mitogen-induced proliferation of spleen lymphocytes of mice by hispolon and hispidin. Die Pharmazie, 1996, Volume: 51, Issue:9 The effects of two phenolic compounds, hispolon and hispidin isolated from fruit bodies of the basidiomycete Inonotus hispidus (Bull. ex Fr.) Karst, were investigated on the chemiluminescence response by LPS- or zymosan-activated human mononuclear cells (MNC) and on the concanavalin A-induced proliferation of spleen lymphocytes of mouse in vitro. Both compounds showed inhibitory activity in the chemiluminescence-test with an IC50 (the concentration of test compound causing 50% effect) ranging from 4.4 to 4.6 micrograms/ml (20.3 to 21.2 microM) for hispolon and < 0.1 to 1.5 micrograms/ml (from < 0.4 microM to 6.0 microM) for hispidin. Antiproliferative effects have been achieved in the lymphocyte transformation test (LTT) by hispolon with an IC50 of 3.4 micrograms/ml (15.5 microM). Topics: Animals; Basidiomycota; Catechols; Cell Division; Cells, Cultured; Concanavalin A; Humans; Lipopolysaccharides; Luminescent Measurements; Lymphocytes; Mice; Mice, Inbred ICR; Mitogens; Monocytes; Pyrones; Spleen; Thymidine; Zymosan	1996

Article

Year

Inhibition of chemiluminescence response of human mononuclear cells and suppression of mitogen-induced proliferation of spleen lymphocytes of mice by hispolon and hispidin.

Die Pharmazie, 1996, Volume: 51, Issue:9

The effects of two phenolic compounds, hispolon and hispidin isolated from fruit bodies of the basidiomycete Inonotus hispidus (Bull. ex Fr.) Karst, were investigated on the chemiluminescence response by LPS- or zymosan-activated human mononuclear cells (MNC) and on the concanavalin A-induced proliferation of spleen lymphocytes of mouse in vitro. Both compounds showed inhibitory activity in the chemiluminescence-test with an IC50 (the concentration of test compound causing 50% effect) ranging from 4.4 to 4.6 micrograms/ml (20.3 to 21.2 microM) for hispolon and < 0.1 to 1.5 micrograms/ml (from < 0.4 microM to 6.0 microM) for hispidin. Antiproliferative effects have been achieved in the lymphocyte transformation test (LTT) by hispolon with an IC50 of 3.4 micrograms/ml (15.5 microM).

Topics: Animals; Basidiomycota; Catechols; Cell Division; Cells, Cultured; Concanavalin A; Humans; Lipopolysaccharides; Luminescent Measurements; Lymphocytes; Mice; Mice, Inbred ICR; Mitogens; Monocytes; Pyrones; Spleen; Thymidine; Zymosan

1996