concanavalin-a and diucifon

The results of comparative investigation of diucifon effect on the level of natural killer cell activity in young and old mice are presented. An increase in the natural cytotoxic activity, as indicated by 51Cr-release micro-test, was considerably higher in old than in young mice during 1-3 days after diucifon administration. However, after diucifon stimulation the level of natural killer cell activity in old mice was significantly lower than in intact young mice.

Topics: Adjuvants, Immunologic; Aging; Animals; Concanavalin A; Cytotoxicity, Immunologic; Drug Combinations; Interleukin-2; Killer Cells, Natural; Mice; Mice, Inbred CBA; Spleen; Sulfones; Time Factors; Uracil

The current concepts of the mechanisms of initiation and regulation of the proliferative response of lymphoid cells underlie a series of research performed by the authors. Using the modern methods an attempt was made to analyze comprehensively the causes of its lowering in patients with congenital immune deficiency (ataxia-telangiectasia, the Louis-Bar syndrome). It was established that irresponsiveness of the patients' cells to mitogens is not associated with the inability of these cells to interact with mitogen, to produce the growth factor of T cells or adsorb it on their membrane. It is suggested that the derangement is likely to be connected with the blockade of the postmembrane component of the proliferation trigger. It is also assumed that the analysis of the low proliferative response employed by the authors can be successfully used for other pathologies.

Topics: Ataxia Telangiectasia; Concanavalin A; Drug Combinations; Humans; Interleukin-1; Interleukin-2; Lymphocyte Activation; Phytohemagglutinins; Sulfones; Uracil