concanavalin-a and coumarin

concanavalin-a has been researched along with coumarin* in 1 studies

Other Studies

1 other study(ies) available for concanavalin-a and coumarin

Article	Year
Immunosuppressive activity of daphnetin, one of coumarin derivatives, is mediated through suppression of NF-κB and NFAT signaling pathways in mouse T cells. PloS one, 2014, Volume: 9, Issue:5 Daphnetin, a plant-derived dihydroxylated derivative of coumarin, is an effective compound extracted from a plant called Daphne Korean Nakai. Coumarin derivates were known for their antithrombotic, anti-inflammatory, and antioxidant activities. The present study was aimed to determine the immunosuppressive effects and the underlying mechanisms of daphnetin on concanavalin A (ConA) induced T lymphocytes in mice. We showed that, in vitro, daphnetin suppressed ConA-induced splenocyte proliferation, influenced production of the cytokines and inhibited cell cycle progression through the G0/G1 transition. The data also revealed that daphnetin could down-regulate activation of ConA induced NF-κB and NFAT signal transduction pathways in mouse T lymphocyte. In vivo, daphnetin treatment significantly inhibited the 2, 4- dinitrofluorobenzene (DNFB) -induced delayed type hypersensitivity (DTH) reactions in mice. Collectively, daphnetin had strong immunosuppressive activity both in vitro and in vivo, suggesting a potential role for daphnetin as an immunosuppressive agent, and established the groundwork for further research on daphnetin. Topics: Animals; Cell Proliferation; Concanavalin A; Coumarins; Down-Regulation; G1 Phase; Hypersensitivity, Delayed; Immunosuppressive Agents; Male; Mice; Mice, Inbred BALB C; NF-kappa B; NFATC Transcription Factors; Resting Phase, Cell Cycle; Signal Transduction; T-Lymphocytes; Umbelliferones	2014

Article

Year

Immunosuppressive activity of daphnetin, one of coumarin derivatives, is mediated through suppression of NF-κB and NFAT signaling pathways in mouse T cells.

PloS one, 2014, Volume: 9, Issue:5

Daphnetin, a plant-derived dihydroxylated derivative of coumarin, is an effective compound extracted from a plant called Daphne Korean Nakai. Coumarin derivates were known for their antithrombotic, anti-inflammatory, and antioxidant activities. The present study was aimed to determine the immunosuppressive effects and the underlying mechanisms of daphnetin on concanavalin A (ConA) induced T lymphocytes in mice. We showed that, in vitro, daphnetin suppressed ConA-induced splenocyte proliferation, influenced production of the cytokines and inhibited cell cycle progression through the G0/G1 transition. The data also revealed that daphnetin could down-regulate activation of ConA induced NF-κB and NFAT signal transduction pathways in mouse T lymphocyte. In vivo, daphnetin treatment significantly inhibited the 2, 4- dinitrofluorobenzene (DNFB) -induced delayed type hypersensitivity (DTH) reactions in mice. Collectively, daphnetin had strong immunosuppressive activity both in vitro and in vivo, suggesting a potential role for daphnetin as an immunosuppressive agent, and established the groundwork for further research on daphnetin.

Topics: Animals; Cell Proliferation; Concanavalin A; Coumarins; Down-Regulation; G1 Phase; Hypersensitivity, Delayed; Immunosuppressive Agents; Male; Mice; Mice, Inbred BALB C; NF-kappa B; NFATC Transcription Factors; Resting Phase, Cell Cycle; Signal Transduction; T-Lymphocytes; Umbelliferones

2014