concanavalin-a and calmidazolium

concanavalin-a has been researched along with calmidazolium* in 1 studies

Other Studies

1 other study(ies) available for concanavalin-a and calmidazolium

Article	Year
On the role of intracellular concentration of Ca2+ and H+ in thymocyte death after irradiation. FEBS letters, 1993, Jun-21, Volume: 324, Issue:3 The role of intracellular Ca2+ and H+ concentrations in radiation-induced interphase death of rat thymocytes has been studied. In response to concanavalin A treatment in the Ca(2+)-containing medium, or to the CaCl2 treatment in the Ca(2+)-free medium, the [Ca2+]i rise in irradiated cells was as in the non-treated cells. No changes in the level of [Ca2+]i and pHi were found within 1 h after irradiation of thymocytes with a dose of 6 Gy. 15 microM 5-(N-ethyl-N-isopropyl)-amiloride, an inhibitor of Na+/H+ exchange, did not affect the DNA fragmentation. The fragmentation was prevented by 2-4 microM (1-[bis(4-chlorophenyl)methyl]-3-[2-(2,4-dichlorophenyl)]-2-[(2,4- dichlorophenyl)-methoxy]-ethyl)-1-H-imidazolium chloride, an inhibitor of calmodulin. The above data indicate that triggering of interphase death in irradiated thymocytes is not mediated by changes in either [Ca2+]i or pHi. Such changes seem to be involved in intermediate steps of the interphase death process. Topics: Amiloride; Animals; Antiporters; Biological Transport; Calcium; Calmodulin; Cell Death; Concanavalin A; DNA Damage; Hydrogen-Ion Concentration; Imidazoles; Male; Radiation Injuries, Experimental; Rats; Rats, Wistar; Thymus Gland; Time Factors	1993

Article

Year

On the role of intracellular concentration of Ca2+ and H+ in thymocyte death after irradiation.

FEBS letters, 1993, Jun-21, Volume: 324, Issue:3

The role of intracellular Ca2+ and H+ concentrations in radiation-induced interphase death of rat thymocytes has been studied. In response to concanavalin A treatment in the Ca(2+)-containing medium, or to the CaCl2 treatment in the Ca(2+)-free medium, the [Ca2+]i rise in irradiated cells was as in the non-treated cells. No changes in the level of [Ca2+]i and pHi were found within 1 h after irradiation of thymocytes with a dose of 6 Gy. 15 microM 5-(N-ethyl-N-isopropyl)-amiloride, an inhibitor of Na+/H+ exchange, did not affect the DNA fragmentation. The fragmentation was prevented by 2-4 microM (1-[bis(4-chlorophenyl)methyl]-3-[2-(2,4-dichlorophenyl)]-2-[(2,4- dichlorophenyl)-methoxy]-ethyl)-1-H-imidazolium chloride, an inhibitor of calmodulin. The above data indicate that triggering of interphase death in irradiated thymocytes is not mediated by changes in either [Ca2+]i or pHi. Such changes seem to be involved in intermediate steps of the interphase death process.

Topics: Amiloride; Animals; Antiporters; Biological Transport; Calcium; Calmodulin; Cell Death; Concanavalin A; DNA Damage; Hydrogen-Ion Concentration; Imidazoles; Male; Radiation Injuries, Experimental; Rats; Rats, Wistar; Thymus Gland; Time Factors

1993