concanavalin-a and caffeic-acid

concanavalin-a has been researched along with caffeic-acid* in 2 studies

Other Studies

2 other study(ies) available for concanavalin-a and caffeic-acid

Article	Year
Contribution of lipoxygenase metabolites to IL-2 production in the early phase of lymphocyte activation. Prostaglandins, leukotrienes, and medicine, 1986, Volume: 22, Issue:3 Lipoxygenase inhibitors; eicosatetraynoic acid (ETYA), esculetin and caffeic acid, inhibited interleukin-2 (IL-2) production by Con A (concanavalin A)-stimulated murine spleen lymphocytes. They effectively inhibited IL-2 production without affecting cell viability when they were added to the cultures within around 6 hr after Con A stimulation. IL-1 production was also inhibited effectively when the inhibitors were added within 4 hr after stimulation. Therefore, immunosuppressive characteristics of these inhibitors can in part be explained by their inhibitory effects on production of lymphokines involved in the early phase of lymphocyte activation. Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acids; Caffeic Acids; Concanavalin A; Female; Interleukin-1; Interleukin-2; Lipoxygenase; Lipoxygenase Inhibitors; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Umbelliferones	1986
Lipoxygenase specific inhibitors inhibit murine lymphocyte reactivity to Con A by reducing IL-2 production and its action. Prostaglandins, leukotrienes, and medicine, 1985, Volume: 18, Issue:1 Caffeic acid and AA861, specific inhibitors of lipoxygenase, reduced reactivity of murine spleen lymphocytes to Concanavalin A (Con A). They inhibited interleukin-2 (IL-2) production and its action, although they did not inhibit acquisition of lymphocyte reactivity to IL-2. Indomethacin was not able to restore the reactivity of lymphocytes to Con A even when it was combined with lipoxygenase specific inhibitors. This result suggests that lipoxygenase inhibitors exert their effects not through increasing prostaglandin E2 (PGE2) production but through inhibiting lipoxygenase. Lipoxygenase inhibitors exerted their effects even though they were removed 24 hr after the onset of culture. Taken together, these results suggest that lipoxygenase inhibitors exerted their inhibitory effects in the early period of lymphocyte activation by reducing IL-2 production and its action, implying that lipoxygenase reactions during 24 hr after stimulation may be involved in these steps. Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Benzoquinones; Caffeic Acids; Cells, Cultured; Cinnamates; Concanavalin A; Female; Indomethacin; Interleukin-2; Lipoxygenase Inhibitors; Lymphocyte Activation; Lymphocytes; Mice; Mice, Inbred BALB C; Quinones	1985

Article

Year

Contribution of lipoxygenase metabolites to IL-2 production in the early phase of lymphocyte activation.

Prostaglandins, leukotrienes, and medicine, 1986, Volume: 22, Issue:3

Lipoxygenase inhibitors; eicosatetraynoic acid (ETYA), esculetin and caffeic acid, inhibited interleukin-2 (IL-2) production by Con A (concanavalin A)-stimulated murine spleen lymphocytes. They effectively inhibited IL-2 production without affecting cell viability when they were added to the cultures within around 6 hr after Con A stimulation. IL-1 production was also inhibited effectively when the inhibitors were added within 4 hr after stimulation. Therefore, immunosuppressive characteristics of these inhibitors can in part be explained by their inhibitory effects on production of lymphokines involved in the early phase of lymphocyte activation.

Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acids; Caffeic Acids; Concanavalin A; Female; Interleukin-1; Interleukin-2; Lipoxygenase; Lipoxygenase Inhibitors; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Umbelliferones

1986

Lipoxygenase specific inhibitors inhibit murine lymphocyte reactivity to Con A by reducing IL-2 production and its action.

Prostaglandins, leukotrienes, and medicine, 1985, Volume: 18, Issue:1

Caffeic acid and AA861, specific inhibitors of lipoxygenase, reduced reactivity of murine spleen lymphocytes to Concanavalin A (Con A). They inhibited interleukin-2 (IL-2) production and its action, although they did not inhibit acquisition of lymphocyte reactivity to IL-2. Indomethacin was not able to restore the reactivity of lymphocytes to Con A even when it was combined with lipoxygenase specific inhibitors. This result suggests that lipoxygenase inhibitors exert their effects not through increasing prostaglandin E2 (PGE2) production but through inhibiting lipoxygenase. Lipoxygenase inhibitors exerted their effects even though they were removed 24 hr after the onset of culture. Taken together, these results suggest that lipoxygenase inhibitors exerted their inhibitory effects in the early period of lymphocyte activation by reducing IL-2 production and its action, implying that lipoxygenase reactions during 24 hr after stimulation may be involved in these steps.

Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Benzoquinones; Caffeic Acids; Cells, Cultured; Cinnamates; Concanavalin A; Female; Indomethacin; Interleukin-2; Lipoxygenase Inhibitors; Lymphocyte Activation; Lymphocytes; Mice; Mice, Inbred BALB C; Quinones

1985