concanavalin-a and caffeic-acid-phenethyl-ester

concanavalin-a has been researched along with caffeic-acid-phenethyl-ester* in 1 studies

Other Studies

1 other study(ies) available for concanavalin-a and caffeic-acid-phenethyl-ester

Article	Year
Inhibition of ICE-family cysteine proteases rescues murine lymphocytes from lipoxygenase inhibitor-induced apoptosis. FEBS letters, 1996, Nov-04, Volume: 396, Issue:2-3 Two lipophilic derivatives of caffeic acid which inhibit lipoxygenase, caffeic acid phenethyl ester (CAPE) and N,N'-dicyclohexyl-O-(3,4-dihydroxycinnamoyl)-isourea (DCHCU), reduced the proliferative response of murine splenocytes to concanavalin A in vitro. Both CAPE and DCHCU induced apoptosis in murine thymocyte cultures as verified by flow cytometry and by visualisation of DNA with acridine orange staining. CAPE-induced apoptosis was inhibited by z-VAD-fmk, an inhibitor of the interleukin-1beta-converting enzyme family of cysteine proteases. We suggest that the lipoxygenase pathway of arachidonic acid metabolism plays a role in regulating lymphocyte responses such as proliferation and apoptosis. Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Caffeic Acids; Caspase 1; Cell Division; Cells, Cultured; Concanavalin A; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Lipoxygenase Inhibitors; Lymphocytes; Male; Mice; Mice, Inbred C57BL; Phenylethyl Alcohol; Propolis; Quercetin; T-Lymphocytes; Urea	1996

Article

Year

Inhibition of ICE-family cysteine proteases rescues murine lymphocytes from lipoxygenase inhibitor-induced apoptosis.

FEBS letters, 1996, Nov-04, Volume: 396, Issue:2-3

Two lipophilic derivatives of caffeic acid which inhibit lipoxygenase, caffeic acid phenethyl ester (CAPE) and N,N'-dicyclohexyl-O-(3,4-dihydroxycinnamoyl)-isourea (DCHCU), reduced the proliferative response of murine splenocytes to concanavalin A in vitro. Both CAPE and DCHCU induced apoptosis in murine thymocyte cultures as verified by flow cytometry and by visualisation of DNA with acridine orange staining. CAPE-induced apoptosis was inhibited by z-VAD-fmk, an inhibitor of the interleukin-1beta-converting enzyme family of cysteine proteases. We suggest that the lipoxygenase pathway of arachidonic acid metabolism plays a role in regulating lymphocyte responses such as proliferation and apoptosis.

Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Caffeic Acids; Caspase 1; Cell Division; Cells, Cultured; Concanavalin A; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Lipoxygenase Inhibitors; Lymphocytes; Male; Mice; Mice, Inbred C57BL; Phenylethyl Alcohol; Propolis; Quercetin; T-Lymphocytes; Urea

1996