concanavalin-a has been researched along with 4-amino-4--hydroxylaminodiphenylsulfone* in 1 studies
1 other study(ies) available for concanavalin-a and 4-amino-4--hydroxylaminodiphenylsulfone
| Article | Year |
|---|---|
Improvement of polymorphonuclear leucocyte oxidative and bactericidal functions in chronic granulomatous disease with 4-amino-4'-hydroxylaminodiphenyl sulphone.
In an effort to restore oxidant-dependent capabilities to chronic granulomatous disease (CGD) polymorphonuclear leucocytes (PMN), we studied a dapsone derivative, 4-amino-4'-hydroxylaminodiphenyl sulphone (DDS-NOH), known to generate H2O2. After incubation of CGD PMN with 0.2 and 1.0 mM DDS-NOH for 30 min, the rate of glucose-1-14C oxidation via hexose monophosphate (HMP) shunt increased 2--4-fold and that of iodination of ingested zymosan particles 1.5--2.7-fold. Both effects could be further enhanced by superoxide dismutase (SOD) but inhibited by catalase. In three patients, 0.2 mM DDS-NOH improved in vitro killing of Staph. aureus. DDS-NOH 0.02 mM induced capping of Concanavalin A (Con A) receptor complexes suggesting interference by the drug with microtubule-associated function. Thus, optimal concentrations of DDS-NOH may be employed as an oxidant to improve metabolic and bactericidal functions of PMN from patients with CGD. Topics: Aminobiphenyl Compounds; Blood Bactericidal Activity; Catalase; Concanavalin A; Dapsone; Glucose; Granulomatous Disease, Chronic; Humans; Immunologic Capping; Neutrophils; Superoxide Dismutase | 1978 |