concanavalin-a and 4-7-10-13-eicosatetraynoic-acid

concanavalin-a has been researched along with 4-7-10-13-eicosatetraynoic-acid* in 1 studies

Other Studies

1 other study(ies) available for concanavalin-a and 4-7-10-13-eicosatetraynoic-acid

ArticleYear
Lipoxygenase inhibitors exert secretagogue-specific effects on mast cell exocytosis.
    European journal of pharmacology, 1982, Apr-23, Volume: 79, Issue:3-4

    The lipoxygenase inhibitors HTYA (5,8,11,14-henicosatetraynoic acid, 25-150 microM) and ITYA (4,7,10,13-icosatetraynoic acid, 25-75 microM), inhibited histamine secretion from rat mast cells evoked by concanavalin A but that elicited by compound 48/80 or polymyxin B. Arachidonic acid (100 microM) did not inhibit concanavalin A-induced histamine secretion. The results are consistent with the notion that lipoxygenase inhibitors affect an early stage of stimulus-secretion coupling in the mast cell, peculiar to antibody-directed secretagogues, perhaps that involving calcium influx.

    Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Concanavalin A; Exocytosis; Histamine Release; Lipoxygenase Inhibitors; Male; Mast Cells; p-Methoxy-N-methylphenethylamine; Polymyxin B; Rats; Rats, Inbred Strains

1982