concanamycin-a has been researched along with hygrolidin* in 2 studies
2 other study(ies) available for concanamycin-a and hygrolidin
Article | Year |
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Development of a concise and diversity-oriented approach for the synthesis of plecomacrolides via the diene-ene RCM.
[reaction: see text] A concise synthesis of the core structures of plecomacrolide with ring sizes varying from 16 to 19 atoms was achieved for the first time by the diene-ene ring-closing olefin metathesis reaction. This approach should allow access to the structurally diverse analogues of plecomacrolide. Topics: Biological Products; Catalysis; Cyclization; Macrolides; Molecular Structure | 2006 |
Studies on the synthesis of bafilomycin A(1): stereochemical aspects of the fragment assembly aldol reaction for construction of the C(13)-C25) segment.
Highly stereoselective syntheses of aldols 8a-c corresponding to the C(13)-C(25) segment of bafilomycin A(1) were developed by routes involving fragment assembly aldol reactions of chiral aldehyde 6a and the chiral methyl ketones 7. A remote chelation effect plays a critical role in determining the stereoselectivity of the key aldol coupling of 6a and the lithium enolate of 7b. The protecting group for C(23)-OH of the chiral aldehyde fragment also influences the selectivity of the lithium enolate aldol reaction. In contrast, the aldol reaction of 6a and the chlorotitanium enolates of 7a,c were much less sensitive to the nature of the C(15)-hydroxyl protecting group. Studies of the reactions of chiral aldehydes with Takai's (gamma-methoxyallyl)chromium reagent 40 are also described. The stereoselectivity of these reactions is also highly dependent on the protecting groups and stereochemistry of the chiral aldehyde substrates. Topics: Aldehydes; Anti-Bacterial Agents; Catalysis; Crystallography, X-Ray; Lithium Compounds; Macrolides; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Stereoisomerism | 2002 |