concanamycin-a and benzo-1-2-3-thiadiazole

Autophagy is a major catabolic process in eukaryotes with a key role in homeostasis, programmed cell death, and aging. In plants, autophagy is also known to regulate agronomically important traits such as stress resistance, longevity, vegetative biomass, and seed yield. Despite its significance, there is still a shortage of reliable tools modulating plant autophagy. Here, we describe the first robust pipeline for identification of specific plant autophagy-modulating compounds. Our screening protocol comprises four phases: (1) high-throughput screening of chemical compounds in cell cultures of tobacco (

Topics: Arabidopsis; Autophagy; Cell Survival; Drug Evaluation, Preclinical; Macrolides; Morpholines; Nicotiana; Organic Chemicals; Thiadiazoles