compound 20 has been researched along with captopril in 7 studies
*Captopril: A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin. [MeSH]
*Captopril: A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin. [MeSH]
| Studies (compound 20) | Trials (compound 20) | Recent Studies (post-2010) (compound 20) | Studies (captopril) | Trials (captopril) | Recent Studies (post-2010) (captopril) |
|---|---|---|---|---|---|
| 9 | 0 | 0 | 10,320 | 1,514 | 890 |
| Protein | Taxonomy | compound 20 (IC50) | captopril (IC50) |
|---|---|---|---|
| Leukotriene A-4 hydrolase | Homo sapiens (human) | 3.6 | |
| Angiotensin-converting enzyme | Homo sapiens (human) | 0.084 | |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | 0.0173 | |
| Succinyl-diaminopimelate desuccinylase | Haemophilus influenzae Rd KW20 | 3.3 | |
| Angiotensin-converting enzyme | Rattus norvegicus (Norway rat) | 0.1004 | |
| Beta-lactamase | Pseudomonas aeruginosa | 5 | |
| Angiotensin-converting enzyme 2 | Homo sapiens (human) | 0.011 | |
| Beta-lactamase class B VIM-2 | Pseudomonas aeruginosa | 3.5 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (85.71) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Almquist, RG; Chao, WR; Judd, AK; Matthews, RJ; Mitoma, C; Panasevich, RE; Rossi, DJ | 1 |
| Allibone, PL; Greenlee, WJ; Patchett, AA; Perlow, DS; Ulm, EH; Vassil, TC | 1 |
| Almquist, RG; Chao, WR; Jennings-White, C; Mitoma, C; Rogers, J; Steeger, T; Wheeler, K | 1 |
| Almquist, RG; Essenburg, AD; Hoefle, ML; Holmes, A; Kaplan, HR; Lunney, EA; Meyer, RF; Nicolaides, ED; Smith, RD; Tinney, FJ | 1 |
| Almquist, RG; Chao, WR; Ellis, ME; Johnson, HL | 1 |
| Almquist, RG; Crase, J; Essenburg, AD; Hoefle, ML; Jennings-White, C; Kaplan, HR; Meyer, RF; Smith, RD | 1 |
| Marshall, GR; Waller, CL | 1 |
7 other study(ies) available for compound 20 and captopril
| Article | Year |
|---|---|
Synthesis and biological activity of ketomethylene-containing nonapeptide analogues of snake venom angiotensin converting enzyme inhibitors.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Chemical Phenomena; Chemistry, Physical; Kinetics; Lung; Oligopeptides; Peptidyl-Dipeptidase A; Rabbits; Snake Venoms; Structure-Activity Relationship | 1988 |
Angiotensin-converting enzyme inhibitors: synthesis and biological activity of acyl tripeptide analogues of enalapril.
Topics: Angiotensin-Converting Enzyme Inhibitors; Dipeptides; Enalapril; Enzyme Inhibitors; Structure-Activity Relationship | 1985 |
Synthesis and biological activity of pentapeptide analogues of the potent angiotensin converting enzyme inhibitor 5(S)-benzamido-4-oxo-6-phenylhexanoyl-L-proline.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Dipeptides; Hypertension, Renovascular; Male; Metabolic Clearance Rate; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1985 |
Novel synthesis of (S)-1-[5-(benzoylamino)-1,4-dioxo-6-phenylhexyl]-L-proline and analogues: potent angiotensin converting enzyme inhibitors.
Topics: Angiotensin II; Animals; Blood Pressure; Dipeptides; Dose-Response Relationship, Drug; Male; Oligopeptides; Rats; Structure-Activity Relationship; Teprotide | 1981 |
Synthesis and biological activity of a ketomethylene analogue of a tripeptide inhibitor of angiotensin converting enzyme.
Topics: Angiotensin I; Angiotensin-Converting Enzyme Inhibitors; Animals; Chemical Phenomena; Chemistry; Dipeptides; Guinea Pigs; In Vitro Techniques; Kinetics; Male; Muscle Contraction | 1980 |
Derivatives of the potent angiotensin converting enzyme inhibitor 5(S)-benzamido-4-oxo-6-phenylhexanoyl-L-proline: effect of changes at positions 2 and 5 of the hexanoic acid portion.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Chemical Phenomena; Chemistry; Dipeptides; Guinea Pigs; Heart Rate; Hypertension, Renal; Male; Rats; Structure-Activity Relationship | 1982 |
Three-dimensional quantitative structure-activity relationship of angiotesin-converting enzyme and thermolysin inhibitors. II. A comparison of CoMFA models incorporating molecular orbital fields and desolvation free energies based on active-analog and com
Topics: Angiotensin-Converting Enzyme Inhibitors; Models, Molecular; Molecular Structure; Structure-Activity Relationship; Thermolysin | 1993 |