Page last updated: 2024-08-26

combretastatin and colchicine

combretastatin has been researched along with colchicine in 20 studies

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19902 (10.00)18.7374
1990's3 (15.00)18.2507
2000's8 (40.00)29.6817
2010's6 (30.00)24.3611
2020's1 (5.00)2.80

Authors

AuthorsStudies
Chu, PS; Getahun, Z; Hamel, E; Jurd, L; Lin, CM1
Chu, PS; Dempcy, RO; Hamel, E; Lin, CM; Pettit, GR; Schmidt, JM; Singh, SB1
Hamel, E; Lin, CM1
Kajiyama, S; Kobayashi, A1
Day, BW; Hamel, E; Rosenkranz, HS; ter Haar, E1
Brown, ML; Macdonald, TL; Rieger, JM1
Kovar, P; Ng, SC; Rosenberg, SH; Tahir, SK1
Chaudhuri, AR; Hausheer, FH; Ludueña, RF; Schwarz, PM; Seetharamalu, P1
Iwasaki, S; Shirai, R1
Bane, SL; Janik, ME1
Ducki, S; Lawrence, NJ; Mackenzie, G; Snyder, JP1
Alloatti, D; Baruchello, R; Bucci, F; Carminati, P; Castorina, M; Giannini, G; Guglielmi, MB; Marcellini, M; Pavani, MG; Pisano, C; Riccioni, T; Rizzi, M; Romagnoli, R; Rondanin, R; Simoni, D1
Armitage, S; Bennett, E; Chabert, JF; Ducki, S; Greedy, B; Lawrence, NJ; Mackenzie, G; Nettles, J; Snyder, JP1
Baraldi, PG; Basso, G; Bortolozzi, R; Brancale, A; Carrion, MD; Chen, L; Cruz-Lopez, O; Hamel, E; Lopez Cara, C; Romagnoli, R; Viola, G1
Chaplin, DJ; Garner, CM; Ghatak, A; Hadimani, MB; Hall, JJ; Hamel, E; Kessler, RJ; Liu, L; Lopez, R; Macdonough, MT; Mason, RP; Nguyen, BL; Pettit, GR; Pinney, KG; Shirali, AR; Sriram, M; Strecker, TE; Trawick, ML1
Lemelle, E; McFerrin, H; Mottamal, M; Wang, G; Zhang, C; Zhang, Q; Zheng, S; Zhong, Q1
Álvarez, R; López, V; Mateo, C; Medarde, M; Peláez, R1
Bai, Z; Bao, K; Feng, D; Guan, Q; Jiang, M; Jiang, N; Li, C; Qi, H; Wu, Y; Yang, L; Zhai, Y; Zhang, W; Zuo, D1
Bartenschlager, R; Boldescu, V; Dimoglo, A; Graf, D; Klein, CD; Richter, M; Streicher, F1
Kumar, D; Kumar, S; Sharma, P; Shri, R1

Reviews

3 review(s) available for combretastatin and colchicine

ArticleYear
[Molecular basis of probes for cytoskeletal proteins].
    Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 1993, Volume: 38, Issue:11

    Topics: Animals; Bibenzyls; Colchicine; Cytoskeletal Proteins; Fertilization; Microtubules; Mitosis; Paclitaxel; Sea Urchins; Stilbenes; Zearalenone

1993
[Natural organic compounds that affect to microtubule functions: syntheses and structure-activity relationships of combretastatins, curacin A and their analogs as the colchicine-site ligands on tubulin].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2000, Volume: 120, Issue:10

    Topics: Bibenzyls; Binding Sites; Cell Cycle; Colchicine; Cyclopropanes; Ligands; Microtubules; Protein Binding; Stilbenes; Structure-Activity Relationship; Thiazoles; Tubulin

2000
Mechanistic Insights and Docking Studies of Phytomolecules as Potential Candidates in the Management of Cancer.
    Current pharmaceutical design, 2022, Volume: 28, Issue:33

    Topics: Antineoplastic Agents; Bibenzyls; Colchicine; Curcumin; Humans; Molecular Docking Simulation; Neoplasms; Paclitaxel

2022

Other Studies

17 other study(ies) available for combretastatin and colchicine

ArticleYear
Synthesis of alkoxy-substituted diaryl compounds and correlation of ring separation with inhibition of tubulin polymerization: differential enhancement of inhibitory effects under suboptimal polymerization reaction conditions.
    Journal of medicinal chemistry, 1992, Mar-20, Volume: 35, Issue:6

    Topics: Animals; Antineoplastic Agents; Bibenzyls; Binding Sites; Bridged-Ring Compounds; Colchicine; Leukemia L1210; Mice; Stilbenes; Structure-Activity Relationship; Tubulin

1992
Interactions of tubulin with potent natural and synthetic analogs of the antimitotic agent combretastatin: a structure-activity study.
    Molecular pharmacology, 1988, Volume: 34, Issue:2

    Topics: Animals; Anisoles; Antineoplastic Agents; Bibenzyls; Binding Sites; Binding, Competitive; Colchicine; Leukemia L1210; Mice; Mitosis; Podophyllotoxin; Protein Binding; Stilbenes; Structure-Activity Relationship; Tubulin

1988
Interactions of combretastatin, a new plant-derived antimitotic agent, with tubulin.
    Biochemical pharmacology, 1983, Dec-15, Volume: 32, Issue:24

    Topics: Animals; Anisoles; Bibenzyls; Binding Sites; Brain Chemistry; Cattle; Cells, Cultured; Colchicine; Leukemia L1210; Mice; Mitosis; Protein Binding; Stilbenes; Tubulin

1983
Computational and molecular modeling evaluation of the structural basis for tubulin polymerization inhibition by colchicine site agents.
    Bioorganic & medicinal chemistry, 1996, Volume: 4, Issue:10

    Topics: Antineoplastic Agents, Phytogenic; Bibenzyls; Binding Sites; Colchicine; Models, Molecular; Paclitaxel; Podophyllotoxin; Protein Conformation; Software; Stilbenes; Tubulin; Tubulin Modulators

1996
Comparative molecular field analysis of colchicine inhibition and tubulin polymerization for combretastatins binding to the colchicine binding site on beta-tubulin.
    Bioorganic & medicinal chemistry, 2000, Volume: 8, Issue:6

    Topics: Bibenzyls; Binding Sites; Biopolymers; Colchicine; Molecular Conformation; Stilbenes; Tubulin

2000
Rapid colchicine competition-binding scintillation proximity assay using biotin-labeled tubulin.
    BioTechniques, 2000, Volume: 29, Issue:1

    Topics: Aminophenols; Bibenzyls; Binding Sites; Binding, Competitive; Biotinylation; Colchicine; Demecolcine; Mebendazole; Microspheres; Podophyllotoxin; Scintillation Counting; Solvents; Stilbenes; Streptavidin; Sulfonamides; Tritium; Tubulin; Yttrium

2000
The interaction of the B-ring of colchicine with alpha-tubulin: a novel footprinting approach.
    Journal of molecular biology, 2000, Nov-10, Volume: 303, Issue:5

    Topics: Amino Acid Sequence; Animals; Bibenzyls; Binding Sites; Cattle; Chromatography, High Pressure Liquid; Colchicine; Fluorescence; Models, Molecular; Molecular Sequence Data; Peptide Fragments; Podophyllotoxin; Protein Conformation; Protein Footprinting; Stilbenes; Tropolone; Tryptophan; Tubulin; Urea

2000
Synthesis and antimicrotubule activity of combretatropone derivatives.
    Bioorganic & medicinal chemistry, 2002, Volume: 10, Issue:6

    Topics: Antineoplastic Agents; Bibenzyls; Colchicine; Magnetic Resonance Spectroscopy; Microtubules; Molecular Structure; Stilbenes; Structure-Activity Relationship; Tubulin; Tubulin Modulators

2002
Quantitative structure-activity relationship (5D-QSAR) study of combretastatin-like analogues as inhibitors of tubulin assembly.
    Journal of medicinal chemistry, 2005, Jan-27, Volume: 48, Issue:2

    Topics: Antineoplastic Agents; Bibenzyls; Binding Sites; Colchicine; Ligands; Models, Molecular; Molecular Conformation; Monte Carlo Method; Quantitative Structure-Activity Relationship; Stilbenes; Tubulin; Tubulin Modulators

2005
Novel combretastatin analogues endowed with antitumor activity.
    Journal of medicinal chemistry, 2006, Jun-01, Volume: 49, Issue:11

    Topics: Animals; Antineoplastic Agents; Benzofurans; Bibenzyls; Binding, Competitive; Biopolymers; Cell Line, Tumor; Cell Nucleus; Colchicine; Endothelial Cells; Endothelium, Vascular; Female; Humans; Mice; Mice, Nude; Microtubules; Organophosphates; Prodrugs; Stereoisomerism; Stilbenes; Structure-Activity Relationship; Thiophenes; Tubulin; Xenograft Model Antitumor Assays

2006
Combretastatin-like chalcones as inhibitors of microtubule polymerisation. Part 2: Structure-based discovery of alpha-aryl chalcones.
    Bioorganic & medicinal chemistry, 2009, Nov-15, Volume: 17, Issue:22

    Topics: Algorithms; Bibenzyls; Binding Sites; Cell Line; Chalcones; Colchicine; Drug Discovery; Humans; Hydrocarbons, Cyclic; Microtubules; Structure-Activity Relationship; Tubulin Modulators

2009
Synthesis and antitumor activity of 1,5-disubstituted 1,2,4-triazoles as cis-restricted combretastatin analogues.
    Journal of medicinal chemistry, 2010, May-27, Volume: 53, Issue:10

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Apoptosis; Bibenzyls; Caspase 3; Cell Line, Tumor; Cell Shape; Cells, Cultured; Chick Embryo; Colchicine; Drug Screening Assays, Antitumor; Endothelial Cells; Enzyme Activation; G2 Phase; Humans; Membrane Potential, Mitochondrial; Mitochondria; Models, Molecular; Poly(ADP-ribose) Polymerases; Protein Binding; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Structure-Activity Relationship; Triazoles; Tubulin; Tubulin Modulators

2010
Synthesis of a 2-aryl-3-aroyl indole salt (OXi8007) resembling combretastatin A-4 with application as a vascular disrupting agent.
    Journal of natural products, 2013, Sep-27, Volume: 76, Issue:9

    Topics: Animals; Antineoplastic Agents; Bibenzyls; Colchicine; Drug Screening Assays, Antitumor; Humans; Indoles; Inhibitory Concentration 50; Male; Mice; Molecular Structure; Organophosphates; Prodrugs; Prostatic Neoplasms; Stilbenes; Structure-Activity Relationship; Tubulin

2013
Design, synthesis, and biological evaluation of novel pyridine-bridged analogues of combretastatin-A4 as anticancer agents.
    Journal of medicinal chemistry, 2014, Apr-24, Volume: 57, Issue:8

    Topics: Animals; Antineoplastic Agents; Bibenzyls; Binding Sites; Cell Cycle Checkpoints; Cell Line, Tumor; Chick Embryo; Colchicine; Drug Design; Female; Humans; Mice; Mice, Inbred C57BL; Models, Molecular; Polymerization; Pyridines; Structure-Activity Relationship; Tubulin; Tubulin Modulators

2014
p,p-Dihydroxydihydrostilbenophanes related to antimitotic combretastatins. Conformational analysis and its relationship to tubulin inhibition.
    The Journal of organic chemistry, 2014, Aug-01, Volume: 79, Issue:15

    Topics: Antimitotic Agents; Bibenzyls; Colchicine; Macrocyclic Compounds; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Polymerization; Stilbenes; Tubulin Modulators

2014
Microwave-assisted synthesis and biological evaluation of 3,4-diaryl maleic anhydride/N-substituted maleimide derivatives as combretastatin A-4 analogues.
    Bioorganic & medicinal chemistry letters, 2015, Feb-01, Volume: 25, Issue:3

    Topics: Bibenzyls; Binding Sites; Cell Line, Tumor; Cell Proliferation; Colchicine; Drug Design; Humans; Maleic Anhydrides; Maleimides; Microwaves; Molecular Docking Simulation; Protein Structure, Tertiary; Structure-Activity Relationship; Tubulin; Tubulin Modulators

2015
Synthesis, Biological Evaluation, and Molecular Docking of Combretastatin and Colchicine Derivatives and their hCE1-Activated Prodrugs as Antiviral Agents.
    ChemMedChem, 2019, 02-19, Volume: 14, Issue:4

    Topics: Antiviral Agents; Bibenzyls; Binding Sites; Carboxylesterase; Cell Line, Tumor; Cell Survival; Colchicine; Drug Design; Humans; Molecular Docking Simulation; Prodrugs; Protein Structure, Tertiary; Structure-Activity Relationship; Tubulin; Tubulin Modulators; Zika Virus

2019